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2. Rehabilitation in Congenital Hand and Forearm Defects: Rehabilitation of the Child’s Hand—General Aspects

Author

Mancon, Elena M., Bartolomeo, Luigi, Ceccarelli, Elisa, Cesaroni, Sara, Corsi, Claudia, Culicchia, Greta, Gelatti, Ambra, Genova, Roberta, Guerriero, Antonella, Longhi, Sara, Maiolino, Claudia, Meloni, Carmen, Minoia, Silvia, Nobilia, Marta, Pagliaro, Rossella, Paparo, Stefania, Petrillo, Valeria L., Ramella, Michela, Suriano, Federica, Rossi, Patrizia, Tolosa, Francesca, Vecchi, Simona, and Pajardi, Giorgio, editor

Published
2023
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5. A pharmacoeconomic analysis from Italian guidelines for the management of sporadic primary hyperparathyroidism

Author

Attanasio, Roberto, primary, Samperi, Irene, additional, Scoppola, Alessandro, additional, Paoletta, Agostino, additional, Novizio, Roberto, additional, Vescini, Fabio, additional, Borretta, Giorgio, additional, Chiodini, Iacopo, additional, Papini, Enrico, additional, Persichetti, Agnese, additional, Basile, Michele, additional, Boniardi, Marco, additional, Carotti, Marina, additional, Castellano, Elena, additional, Cipriani, Cristiana, additional, Eller-Vainicher, Cristina, additional, Giannini, Sandro, additional, Iacobone, Maurizio, additional, Salcuni, Antonio/////Stefano, additional, Saponaro, Federica, additional, Spiezia, Stefano, additional, Versari, Annibale, additional, Zavatta, Guido, additional, Mitrova, Zuzana, additional, Giovannazzi, Alexia, additional, Saulle, Rosella, additional, Vecchi, Simona, additional, Antonini, Debora, additional, Calo, Giorgio, additional, Cetani, Filomena, additional, Cianferotti, Luisella, additional, Corbetta, Sabrina, additional, De, Rimini Maria Luisa, additional, Falchetti, Alberto, additional, Iannetti, Giovanni, additional, Laureti, Stefano, additional, Lombardi, Celestino/////Pio, additional, Madeo, Bruno, additional, Marcocci, Claudio, additional, Mazzaferro, Sandro, additional, Miele, Vittorio, additional, Minisola, Salvatore, additional, Palermo, Andrea, additional, Pepe, Jessica, additional, Tonzar, Laura, additional, Scillitani, Alfredo, additional, Grimaldi, Franco, additional, Cozzi, Renato, additional, and Attanasio, Roberto, additional

Published
2024
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6. A pharmacoeconomic analysis from Italian guidelines for the management of prolactinomas

Author

Basile, Michele, Valentini, Ilaria, Attanasio, Roberto, Cozzi, Renato, Persichetti, Agnese, Samperi, Irene, Scoppola, Alessandro, Auriemma, Renata Simona, Menis, Ernesto De, Esposito, Felice, Ferrante, Emanuele, Iatì, Giuseppe, Mazzatenta, Diego, Maurizio Poggi, Rudà, Roberta, Tortora, Fabio, Cruciani, Fabio, Mitrova, Zuzana, Saulle, Rosella, Vecchi, Simona, Cappabianca, Paolo, Paoletta, Agostino, Bozzao, Alessandro, Caputo, Marco, Doglietto, Francesco, Ferraù, Francesco, Lania, Andrea Gerardo, Laureti, Stefano, Lello, Stefano, Locatelli, Davide, Maffei, Pietro, Minniti, Giuseppe, Peri, Alessandro, Ruini, Chiara, Settanni, Fabio, Silvani, Antonio, Veronese, Nadia, Grimaldi, Franco, Papini, Enrico, Cicchetti, Americo, Basile, Michele, Valentini, Ilaria, Attanasio, Roberto, Cozzi, Renato, Persichetti, Agnese, Samperi, Irene, Scoppola, Alessandro, Auriemma, Renata Simona, Menis, Ernesto De, Esposito, Felice, Ferrante, Emanuele, Iatì, Giuseppe, Mazzatenta, Diego, Maurizio Poggi, Rudà, Roberta, Tortora, Fabio, Cruciani, Fabio, Mitrova, Zuzana, Saulle, Rosella, Vecchi, Simona, Cappabianca, Paolo, Paoletta, Agostino, Bozzao, Alessandro, Caputo, Marco, Doglietto, Francesco, Ferraù, Francesco, Lania, Andrea Gerardo, Laureti, Stefano, Lello, Stefano, Locatelli, Davide, Maffei, Pietro, Minniti, Giuseppe, Peri, Alessandro, Ruini, Chiara, Settanni, Fabio, Silvani, Antonio, Veronese, Nadia, Grimaldi, Franco, Papini, Enrico, and Cicchetti, Americo

Abstract

Background: Prolactinoma, the most common pituitary adenoma, is usually treated with dopamine agonist (DA) therapy like cabergoline. Surgery is second-line therapy, and radiotherapy is used if surgical treatment fails or in relapsing macroprolactinoma. Objective: This study aimed to provide economic evidence for the management of prolactinoma in Italy, using a cost-of-illness and cost-utility analysis that considered various treatment options, including cabergoline, bromocriptine, temozolomide, radiation therapy, and surgical strategies. Methods: The researchers conducted a systematic literature review for each research question on scientific databases and surveyed a panel of experts for each therapeutic procedure’s specific drivers that contributed to its total cost. Results: The average cost of the first year of treatment was €2,558.91 and €3,287.40 for subjects with microprolactinoma and macroprolactinoma, respectively. Follow-up costs from the second to the fifth year after initial treatment were €798.13 and €1,084.59 per year in both groups. Cabergoline had an adequate cost-utility profile, with an incremental cost-effectiveness ratio (ICER) of €3,201.15 compared to bromocriptine, based on a willingness-to-pay of €40,000 per quality-adjusted life year (QALY) in the reference economy. Endoscopic surgery was more cost-effective than cabergoline, with an ICER of €44,846.64. Considering a willingness-to-pay of €40,000/QALY, the baseline findings show cabergoline to have high cost utility and endoscopic surgery just a tad above that. Conclusions: Due to the favorable cost-utility profile and safety of surgical treatment, pituitary surgery should be considered more frequently as the initial therapeutic approach. This management choice could lead to better outcomes and an appropriate allocation of healthcare resources.

Published
2024

8. Real‐world candidacy to mavacamten in a contemporary hypertrophic obstructive cardiomyopathy population

Author

Bertero, Edoardo, primary, Chiti, Chiara, additional, Schiavo, Maria Alessandra, additional, Tini, Giacomo, additional, Costa, Paolo, additional, Todiere, Giancarlo, additional, Mabritto, Barbara, additional, Dei, Lorenzo‐Lupo, additional, Giannattasio, Alessia, additional, Mariani, Davide, additional, Lofiego, Carla, additional, Santolamazza, Caterina, additional, Monda, Emanuele, additional, Quarta, Giovanni, additional, Barbisan, Davide, additional, Mandoli, Giulia Elena, additional, Mapelli, Massimo, additional, Sguazzotti, Maurizio, additional, Negri, Francesco, additional, De Vecchi, Simona, additional, Ciabatti, Michele, additional, Tomasoni, Daniela, additional, Mazzanti, Andrea, additional, Marzo, Francesca, additional, de Gregorio, Cesare, additional, Raineri, Claudia, additional, Vianello, Pier Filippo, additional, Marchi, Alberto, additional, Biagioni, Giulia, additional, Insinna, Eleonora, additional, Parisi, Vanda, additional, Ditaranto, Raffaello, additional, Barison, Andrea, additional, Giammaresi, Andrea, additional, De Ferrari, Gaetano Maria, additional, Priori, Silvia, additional, Metra, Marco, additional, Pieroni, Maurizio, additional, Patti, Giuseppe, additional, Imazio, Massimo, additional, Perugini, Enrica, additional, Agostoni, Piergiuseppe, additional, Cameli, Matteo, additional, Merlo, Marco, additional, Sinagra, Gianfranco, additional, Senni, Michele, additional, Limongelli, Giuseppe, additional, Ammirati, Enrico, additional, Vagnarelli, Fabio, additional, Crotti, Lia, additional, Badano, Luigi, additional, Calore, Chiara, additional, Gabrielli, Domenico, additional, Re, Federica, additional, Musumeci, Giuseppe, additional, Emdin, Michele, additional, Barbato, Emanuele, additional, Musumeci, Beatrice, additional, Autore, Camillo, additional, Biagini, Elena, additional, Porto, Italo, additional, Olivotto, Iacopo, additional, and Canepa, Marco, additional

Published
2023
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11. The Italian Clinical Practice Guideline for the treatment of tobacco and nicotine dependence

Author

PACIFICI, ROBERTA, primary, MASTROBATTISTA, LUISA, additional, MORTALI, CLAUDIA, additional, PALMI, ILARIA, additional, PICHINI, SIMONA, additional, SOLIMINI, RENATA, additional, AMATO, LAURA, additional, VECCHI, SIMONA, additional, CRUCIANI, FABIO, additional, SAULLE, ROSELLA, additional, CAMPOSERAGNA, ANTONELLA, additional, MINOZZI, SILVIA, additional, MITROVA, ZUZANA, additional, RUGGERI, MATTEO, additional, FAUCI, ALICE JOSEPHINE, additional, NAPOLETANO, ANTONELLO, additional, and COCLITE, DANIELA, additional

Published
2023
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12. The Italian clinical practice guideline for the treatment of tobacco and nicotine dependence

Author

Solimini, Renata, primary, Vecchi, Simona, additional, Fauci, Alice Josephine, additional, Napoletano, Antonello, additional, Coclite, Daniela, additional, Mastrobattista, Luisa, additional, Mortali, Claudia, additional, Palmi, Ilaria, additional, Amato, Laura, additional, Pacifici, Roberta, additional, Group, Experts Panel, additional, Team, Evidence Review, additional, and Pichini, Simona, additional

Published
2023
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13. Italian Guidelines for the Management of Prolactinomas

Author

Cozzi, Renato, primary, Simona Auriemma, Renata, additional, De Menis, Ernesto, additional, Esposito, Felice, additional, Ferrante, Emanuele, additional, Iatì, Giuseppe, additional, Mazzatenta, Diego, additional, Poggi, Maurizio, additional, Rudà, Roberta, additional, Tortora, Fabio, additional, Cruciani, Fabio, additional, Mitrova, Zuzana, additional, Saulle, Rosella, additional, Vecchi, Simona, additional, Basile, Michele, additional, Cappabianca, Paolo, additional, Paoletta, Agostino, additional, Papini, Enrico, additional, Persichetti, Agnese, additional, Samperi, Irene, additional, Scoppola, Alessandro, additional, Bozzao, Alessandro, additional, Caputo, Marco, additional, Doglietto, Francesco, additional, Ferraù, Francesco, additional, Lania, Andrea Gerardo, additional, Laureti, Stefano, additional, Lello, Stefano, additional, Locatelli, Davide, additional, Maffei, Pietro, additional, Minniti, Giuseppe, additional, Peri, Alessandro, additional, Ruini, Chiara, additional, Settanni, Fabio, additional, Silvani, Antonio, additional, Veronese, Nadia, additional, Grimaldi, Franco, additional, and Attanasio, Roberto, additional

Published
2023
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15. Fatality rate and predictors of mortality in an Italian cohort of hospitalized COVID-19 patients

Author

Bellan, Mattia, Patti, Giuseppe, Hayden, Eyal, Azzolina, Danila, Pirisi, Mario, Acquaviva, Antonio, Aimaretti, Gianluca, Aluffi Valletti, Paolo, Angilletta, Roberto, Arioli, Roberto, Avanzi, Gian Carlo, Avino, Gianluca, Balbo, Piero Emilio, Baldon, Giulia, Baorda, Francesca, Barbero, Emanuela, Baricich, Alessio, Barini, Michela, Barone-Adesi, Francesco, Battistini, Sofia, Beltrame, Michela, Bertoli, Matteo, Bertolin, Stephanie, Bertolotti, Marinella, Betti, Marta, Bobbio, Flavio, Boffano, Paolo, Boglione, Lucio, Borrè, Silvio, Brucoli, Matteo, Calzaducca, Elisa, Cammarata, Edoardo, Cantaluppi, Vincenzo, Cantello, Roberto, Capponi, Andrea, Carriero, Alessandro, Casciaro, Francesco Giuseppe, Castello, Luigi Mario, Ceruti, Federico, Chichino, Guido, Chirico, Emilio, Cisari, Carlo, Cittone, Micol Giulia, Colombo, Crizia, Comi, Cristoforo, Croce, Eleonora, Daffara, Tommaso, Danna, Pietro, Della Corte, Francesco, De Vecchi, Simona, Dianzani, Umberto, Di Benedetto, Davide, Esposto, Elia, Faggiano, Fabrizio, Falaschi, Zeno, Ferrante, Daniela, Ferrero, Alice, Gagliardi, Ileana, Gaidano, Gianluca, Galbiati, Alessandra, Gallo, Silvia, Garavelli, Pietro Luigi, Gardino, Clara Ada, Garzaro, Massimiliano, Gastaldello, Maria Luisa, Gavelli, Francesco, Gennari, Alessandra, Giacomini, Greta Maria, Giacone, Irene, Giai Via, Valentina, Giolitti, Francesca, Gironi, Laura Cristina, Gramaglia, Carla, Grisafi, Leonardo, Inserra, Ilaria, Invernizzi, Marco, Krengli, Marco, Labella, Emanuela, Landi, Irene Cecilia, Landi, Raffaella, Leone, Ilaria, Lio, Veronica, Lorenzini, Luca, Maconi, Antonio, Malerba, Mario, Manfredi, Giulia Francesca, Martelli, Maria, Marzari, Letizia, Marzullo, Paolo, Mennuni, Marco, Montabone, Claudia, Morosini, Umberto, Mussa, Marco, Nerici, Ilaria, Nuzzo, Alessandro, Olivieri, Carlo, Padelli, Samuel Alberto, Panella, Massimiliano, Parisini, Andrea, Paschè, Alessio, Pau, Alberto, Pedrinelli, Anita Rebecca, Percivale, Ilaria, Re, Roberta, Rigamonti, Cristina, Rizzi, Eleonora, Rognoni, Andrea, Roveta, Annalisa, Salamina, Luigia, Santagostino, Matteo, Saraceno, Massimo, Savoia, Paola, Sciarra, Marco, Schimmenti, Andrea, Scotti, Lorenza, Spinoni, Enrico, Smirne, Carlo, Tarantino, Vanessa, Tillio, Paolo Amedeo, Vaschetto, Rosanna, Vassia, Veronica, Zagaria, Domenico, Zavattaro, Elisa, Zeppegno, Patrizia, Zottarelli, Francesca, and Sainaghi, Pier Paolo

Published
2020
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16. Real‐world candidacy to mavacamten in a contemporary hypertrophic obstructive cardiomyopathy population.

Author

Bertero, Edoardo, Chiti, Chiara, Schiavo, Maria Alessandra, Tini, Giacomo, Costa, Paolo, Todiere, Giancarlo, Mabritto, Barbara, Dei, Lorenzo‐Lupo, Giannattasio, Alessia, Mariani, Davide, Lofiego, Carla, Santolamazza, Caterina, Monda, Emanuele, Quarta, Giovanni, Barbisan, Davide, Mandoli, Giulia Elena, Mapelli, Massimo, Sguazzotti, Maurizio, Negri, Francesco, and De Vecchi, Simona

Subjects
HYPERTROPHIC cardiomyopathy, VENTRICULAR outflow obstruction, VENTRICULAR ejection fraction
Abstract

Aims: In the EXPLORER‐HCM trial, mavacamten reduced left ventricular outflow tract obstruction (LVOTO) and improved functional capacity of symptomatic hypertrophic obstructive cardiomyopathy (HOCM) patients. We sought to define the potential use of mavacamten by comparing real‐world HOCM patients with those enrolled in EXPLORER‐HCM and assessing their eligibility to treatment. Methods and results: We collected information on HOCM patients followed up at 25 Italian HCM outpatient clinics and with significant LVOTO (i.e. gradient ≥30 mmHg at rest or ≥50 mmHg after Valsalva manoeuvre or exercise) despite pharmacological or non‐pharmacological therapy. Pharmacological or non‐pharmacological therapy resolved LVOTO in 1044 (61.2%) of the 1706 HOCM patients under active follow‐up, whereas 662 patients (38.8%) had persistent LVOTO. Compared to the EXPLORER‐HCM trial population, these real‐world HOCM patients were older (62.1 ± 14.3 vs. 58.5 ± 12.2 years, p = 0.02), had a lower body mass index (26.8 ± 5.3 vs. 29.7 ± 4.9 kg/m2, p < 0.0001) and a more frequent history of atrial fibrillation (21.5% vs. 9.8%, p = 0.027). At echocardiography, they had lower left ventricular ejection fraction (LVEF, 66 ± 7% vs. 74 ± 6%, p < 0.0001), higher left ventricular outflow tract gradients at rest (60 ± 27 vs. 52 ± 29 mmHg, p = 0.003), and larger left atrial volume index (49 ± 16 vs. 40 ± 12 ml/m2, p < 0.0001). Overall, 324 (48.9%) would have been eligible for enrolment in the EXPLORER‐HCM trial and 339 (51.2%) for treatment with mavacamten according to European guidelines. Conclusions: Real‐world HOCM patients differ from the EXPLORER‐HCM population for their older age, lower LVEF and larger atrial volume, potentially reflecting a more advanced stage of the disease. About half of real‐world HOCM patients were found eligible to mavacamten. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Italian Guidelines for the Management of Non-Functioning Benign and Locally Symptomatic Thyroid Nodules

Author

Attanasio, Roberto, primary, Papini, Enrico, additional, Crescenzi, Anna, additional, D'Amore, Annamaria, additional, Deandrea, Maurilio, additional, De Benedictis, Anna, additional, Frasoldati, Andrea, additional, Garberoglio, Roberto, additional, Guglielmi, Rinaldo, additional, Pio Lombardi, Celestino, additional, Mauri, Giovanni, additional, Elisa Miceli, Rosa, additional, Puglisi, Soraya, additional, Rago, Teresa, additional, Salvatore, Domenico, additional, Triggiani, Vincenzo, additional, Van Doorne, Dominique, additional, Mitrova, Zuzana, additional, Saulle, Rosella, additional, Vecchi, Simona, additional, Basile, Michele, additional, Scoppola, Alessandro, additional, Paoletta, Agostino, additional, Persichetti, Agnese, additional, Samperi, Irene, additional, Cozzi, Renato, additional, Grimaldi, Franco, additional, Boniardi, Marco, additional, Camaioni, Angelo, additional, Elisei, Rossella, additional, Guastamacchia, Edoardo, additional, Nati, Giulio, additional, Novo, Tommaso, additional, Salvatori, Massimo, additional, Spiezia, Stefano, additional, Vallone, Gianfranco, additional, and Zini, Michele, additional

Published
2023
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19. Italian good practice recommendations on management of persons with Long-COVID

Author

Giuliano, Marina, primary, Tiple, Dorina, additional, Agostoni, Piergiuseppe, additional, Armocida, Benedetta, additional, Biardi, Ludovico, additional, Bonfigli, Anna Rita, additional, Campana, Andrea, additional, Ciardi, Maria, additional, Di Marco, Fabiano, additional, Floridia, Marco, additional, Gnerre, Paola, additional, Grassi, Tiziana, additional, Grattagliano, Ignazio, additional, Kruger, Paola, additional, Leonardi, Matilde, additional, Liguori, Rocco, additional, Pagani, Elisabetta, additional, Perger, Elisa, additional, Pricci, Flavia, additional, Ruggeri, Marinella, additional, Silenzi, Andrea, additional, Spannella, Francesco, additional, Tascini, Carlo, additional, Teté, Giulia, additional, Tosato, Matteo, additional, Vecchi, Simona, additional, Villa, Marika, additional, and Onder, Graziano, additional

Published
2023
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20. Predictive Value of Echocardiographic Pulmonary to Left Atrial Ratio for In-Hospital Death in Patients with COVID-19

Author

Renda, Giulia, primary, Mennuni, Marco G., additional, Pizzoferrato, Giovanni, additional, Esposto, Daniele, additional, Alberani, Angela, additional, De Vecchi, Simona, additional, Degiovanni, Anna, additional, Giubertoni, Ailia, additional, Spinoni, Enrico Guido, additional, Grisafi, Leonardo, additional, Sagazio, Emanuele, additional, Ucciferri, Claudio, additional, Falasca, Katia, additional, Vecchiet, Jacopo, additional, Gallina, Sabina, additional, and Patti, Giuseppe, additional

Published
2023
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22. Acceptability, equity, feasibility, and values on the use of disease modifying therapies (DMTs) for the treatment of multiple sclerosis: A scoping review protocol

Author

Vecchi, Simona and Amato, Laura

Subjects
equity, systematic review, disease modifying therapies, acceptability, Medicine and Health Sciences, multiple sclerosis, feasibility
Abstract

In this study we will aim to systematically review the acceptability, equity, feasibility and values on using DMTs in adults with multiple sclerosis (MS). The results will scope to inform the development of international Guidelines on the use of essential disease-modifying therapies for MS for low-resource settings

Published
2022
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27. Predictors of Mortality and Cardiovascular Outcome at 6 Months after Hospitalization for COVID-19

Author

Renda, Giulia, primary, Ricci, Fabrizio, additional, Spinoni, Enrico Guido, additional, Grisafi, Leonardo, additional, D’Ardes, Damiano, additional, Mennuni, Marco, additional, Tana, Claudio, additional, Rognoni, Andrea, additional, Bellan, Mattia, additional, Sainaghi, Pier Paolo, additional, Pirisi, Mario, additional, De Vecchi, Simona, additional, Gallina, Sabina, additional, Pierdomenico, Sante Donato, additional, Cipollone, Francesco, additional, and Patti, Giuseppe, additional

Published
2022
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37. Developmental Language Disorder: Early Predictors, Age for the Diagnosis, and Diagnostic Tools. A Scoping Review

Author

Sansavini, Alessandra, primary, Favilla, Maria Elena, additional, Guasti, Maria Teresa, additional, Marini, Andrea, additional, Millepiedi, Stefania, additional, Di Martino, Maria Valeria, additional, Vecchi, Simona, additional, Battajon, Nadia, additional, Bertolo, Laura, additional, Capirci, Olga, additional, Carretti, Barbara, additional, Colatei, Maria Paola, additional, Frioni, Cristina, additional, Marotta, Luigi, additional, Massa, Sara, additional, Michelazzo, Letizia, additional, Pecini, Chiara, additional, Piazzalunga, Silvia, additional, Pieretti, Manuela, additional, Rinaldi, Pasquale, additional, Salvadorini, Renata, additional, Termine, Cristiano, additional, Zuccarini, Mariagrazia, additional, D’Amico, Simonetta, additional, De Cagno, Anna Giulia, additional, Levorato, Maria Chiara, additional, Rossetto, Tiziana, additional, and Lorusso, Maria Luisa, additional

Published
2021
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38. Simple Parameters from Complete Blood Count Predict In-Hospital Mortality in COVID-19

Author

Bellan, Mattia, primary, Azzolina, Danila, additional, Hayden, Eyal, additional, Gaidano, Gianluca, additional, Pirisi, Mario, additional, Acquaviva, Antonio, additional, Aimaretti, Gianluca, additional, Aluffi Valletti, Paolo, additional, Angilletta, Roberto, additional, Arioli, Roberto, additional, Avanzi, Gian Carlo, additional, Avino, Gianluca, additional, Balbo, Piero Emilio, additional, Baldon, Giulia, additional, Baorda, Francesca, additional, Barbero, Emanuela, additional, Baricich, Alessio, additional, Barini, Michela, additional, Barone-Adesi, Francesco, additional, Battistini, Sofia, additional, Beltrame, Michela, additional, Bertoli, Matteo, additional, Bertolin, Stephanie, additional, Bertolotti, Marinella, additional, Betti, Marta, additional, Bobbio, Flavio, additional, Boffano, Paolo, additional, Boglione, Lucio, additional, Borrè, Silvio, additional, Brucoli, Matteo, additional, Calzaducca, Elisa, additional, Cammarata, Edoardo, additional, Cantaluppi, Vincenzo, additional, Cantello, Roberto, additional, Capponi, Andrea, additional, Carriero, Alessandro, additional, Casciaro, Giuseppe Francesco, additional, Castello, Luigi Mario, additional, Ceruti, Federico, additional, Chichino, Guido, additional, Chirico, Emilio, additional, Cisari, Carlo, additional, Cittone, Micol Giulia, additional, Colombo, Crizia, additional, Comi, Cristoforo, additional, Croce, Eleonora, additional, Daffara, Tommaso, additional, Danna, Pietro, additional, Della Corte, Francesco, additional, De Vecchi, Simona, additional, Dianzani, Umberto, additional, Di Benedetto, Davide, additional, Esposto, Elia, additional, Faggiano, Fabrizio, additional, Falaschi, Zeno, additional, Ferrante, Daniela, additional, Ferrero, Alice, additional, Gagliardi, Ileana, additional, Galbiati, Alessandra, additional, Gallo, Silvia, additional, Garavelli, Pietro Luigi, additional, Gardino, Clara Ada, additional, Garzaro, Massimiliano, additional, Gastaldello, Maria Luisa, additional, Gavelli, Francesco, additional, Gennari, Alessandra, additional, Giacomini, Greta Maria, additional, Giacone, Irene, additional, Giai Via, Valentina, additional, Giolitti, Francesca, additional, Gironi, Laura Cristina, additional, Gramaglia, Carla, additional, Grisafi, Leonardo, additional, Inserra, Ilaria, additional, Invernizzi, Marco, additional, Krengli, Marco, additional, Labella, Emanuela, additional, Landi, Irene Cecilia, additional, Landi, Raffaella, additional, Leone, Ilaria, additional, Lio, Veronica, additional, Lorenzini, Luca, additional, Maconi, Antonio, additional, Malerba, Mario, additional, Manfredi, Giulia Francesca, additional, Martelli, Maria, additional, Marzari, Letizia, additional, Marzullo, Paolo, additional, Mennuni, Marco, additional, Montabone, Claudia, additional, Morosini, Umberto, additional, Mussa, Marco, additional, Nerici, Ilaria, additional, Nuzzo, Alessandro, additional, Olivieri, Carlo, additional, Padelli, Samuel Alberto, additional, Panella, Massimiliano, additional, Parisini, Andrea, additional, Paschè, Alessio, additional, Patrucco, Filippo, additional, Patti, Giuseppe, additional, Pau, Alberto, additional, Pedrinelli, Anita Rebecca, additional, Percivale, Ilaria, additional, Ragazzoni, Luca, additional, Re, Roberta, additional, Rigamonti, Cristina, additional, Rizzi, Eleonora, additional, Rognoni, Andrea, additional, Roveta, Annalisa, additional, Salamina, Luigia, additional, Santagostino, Matteo, additional, Saraceno, Massimo, additional, Savoia, Paola, additional, Sciarra, Marco, additional, Schimmenti, Andrea, additional, Scotti, Lorenza, additional, Spinoni, Enrico, additional, Smirne, Carlo, additional, Tarantino, Vanessa, additional, Tillio, Paolo Amedeo, additional, Tonello, Stelvio, additional, Vaschetto, Rosanna, additional, Vassia, Veronica, additional, Zagaria, Domenico, additional, Zavattaro, Elisa, additional, Zeppegno, Patrizia, additional, Zottarelli, Francesca, additional, and Sainaghi, Pier Paolo, additional

Published
2021
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39. Comparative Effectiveness of Pharmacological Interventions for Covid-19: A Systematic Review and Network Meta-Analysis

Author

De Crescenzo, Franco, primary, Amato, Laura, additional, Cruciani, Fabio, additional, Moynihan, Luke P, additional, D’Alò, Gian Loreto, additional, Vecchi, Simona, additional, Saulle, Rosella, additional, Mitrova, Zuzana, additional, Di Franco, Valeria, additional, Addis, Antonio, additional, and Davoli, Marina, additional

Published
2021
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40. Efficacy of the Treatment of Developmental Language Disorder: A Systematic Review

Author

Rinaldi, Sara, primary, Caselli, Maria Cristina, additional, Cofelice, Valentina, additional, D’Amico, Simonetta, additional, De Cagno, Anna Giulia, additional, Della Corte, Giuseppina, additional, Di Martino, Maria Valeria, additional, Di Costanzo, Brigida, additional, Levorato, Maria Chiara, additional, Penge, Roberta, additional, Rossetto, Tiziana, additional, Sansavini, Alessandra, additional, Vecchi, Simona, additional, and Zoccolotti, Pierluigi, additional

Published
2021
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41. Contribution of Atrial Fibrillation to In-Hospital Mortality in Patients With COVID-19

Author

Spinoni, Enrico Guido, primary, Mennuni, Marco, additional, Rognoni, Andrea, additional, Grisafi, Leonardo, additional, Colombo, Crizia, additional, Lio, Veronica, additional, Renda, Giulia, additional, Foglietta, Melissa, additional, Petrilli, Ivan, additional, D’Ardes, Damiano, additional, Sainaghi, Pier Paolo, additional, Aimaretti, Gianluca, additional, Bellan, Mattia, additional, Castello, Luigi, additional, Avanzi, Gian Carlo, additional, Corte, Francesco Della, additional, Krengli, Marco, additional, Pirisi, Mario, additional, Malerba, Mario, additional, Capponi, Andrea, additional, Gallina, Sabina, additional, Pierdomenico, Sante Donato, additional, Cipollone, Francesco, additional, Patti, Giuseppe, additional, Albano, Emanuele, additional, Dianzani, Umberto, additional, Gaidano, Gianluca, additional, Gennari, Alessandra, additional, Gramaglia, Carla, additional, Solli, Martina, additional, Giubertoni, Ailia, additional, Veia, Alessia, additional, Cisari, Carlo, additional, Amedeo Tillio, Paolo, additional, Valletti, Paolo Aluffi, additional, Adesi, Francesco Barone, additional, Barini, Michela, additional, Ferrante, Daniela, additional, De Vecchi, Simona, additional, Santagostino, Matteo, additional, Acquaviva, Antonio, additional, Calzaducca, Elisa, additional, Casciaro, Francesco Giuseppe, additional, Ceruti, Federico, additional, Cittone, Micol Giulia, additional, Di Benedetto, Davide, additional, Gagliardi, Ileana, additional, Giacomini, Greta Maria, additional, Landi, Irene Cecilia, additional, Landi, Raffaella, additional, Manfredi, Giulia Francesca, additional, Pedrinelli, Anita Rebecca, additional, Rigamonti, Cristina, additional, Rizzi, Eleonora, additional, Smirne, Carlo, additional, Vassia, Veronica, additional, Arioli, Roberto, additional, Danna, Pietro, additional, Falaschi, Zeno, additional, Paschè, Alessio, additional, Percivale, Ilaria, additional, Zagaria, Domenico, additional, Beltrame, Michela, additional, Bertoli, Matteo, additional, Galbiati, Alessandra, additional, Gardino, Clara Ada, additional, Gastaldello, Maria Luisa, additional, Via, Valentina Giai, additional, Giolitti, Francesca, additional, Inserra, Ilaria, additional, Labella, Emanuela, additional, Nerici, Ilaria, additional, Gironi, Laura Cristina, additional, Cammarata, Edoardo, additional, Esposto, Elia, additional, Tarantino, Vanessa, additional, Zavattaro, Elisa, additional, Zottarelli, Francesca, additional, Daffara, Tommaso, additional, Ferrero, Alice, additional, Leone, Ilaria, additional, Nuzzo, Alessandro, additional, Baldon, Giulia, additional, Battistini, Sofia, additional, Chirico, Emilio, additional, Lorenzini, Luca, additional, Martelli, Maria, additional, Barbero, Emanuela, additional, Boffano, Paolo, additional, Brucoli, Matteo, additional, Garzaro, Massimiliano, additional, Pau, Alberto, additional, Bertolin, Stephanie, additional, Marzari, Letizia, additional, Avino, Gianluca, additional, Saraceno, Massimo, additional, Morosini, Umberto, additional, Baricich, Alessio, additional, Invernizzi, Marco, additional, Gallo, Silvia, additional, Montabone, Claudia, additional, Padelli, Samuel Alberto, additional, Boglione, Lucio, additional, Patrucco, Filippo, additional, Salamina, Luigia, additional, Baorda, Francesca, additional, Croce, Eleonora, additional, and Giacone, Irene, additional

Published
2021
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42. Respiratory and Psychophysical Sequelae Among Patients With COVID-19 Four Months After Hospital Discharge

Author

Bellan, Mattia, primary, Soddu, Daniele, additional, Balbo, Piero Emilio, additional, Baricich, Alessio, additional, Zeppegno, Patrizia, additional, Avanzi, Gian Carlo, additional, Baldon, Giulia, additional, Bartolomei, Giuseppe, additional, Battaglia, Marco, additional, Battistini, Sofia, additional, Binda, Valeria, additional, Borg, Margherita, additional, Cantaluppi, Vincenzo, additional, Castello, Luigi Mario, additional, Clivati, Elisa, additional, Cisari, Carlo, additional, Costanzo, Martina, additional, Croce, Alessandro, additional, Cuneo, Daria, additional, De Benedittis, Carla, additional, De Vecchi, Simona, additional, Feggi, Alessandro, additional, Gai, Martina, additional, Gambaro, Eleonora, additional, Gattoni, Eleonora, additional, Gramaglia, Carla, additional, Grisafi, Leonardo, additional, Guerriero, Chiara, additional, Hayden, Eyal, additional, Jona, Amalia, additional, Invernizzi, Marco, additional, Lorenzini, Luca, additional, Loreti, Lucia, additional, Martelli, Maria, additional, Marzullo, Paolo, additional, Matino, Erica, additional, Panero, Antonio, additional, Parachini, Elena, additional, Patrucco, Filippo, additional, Patti, Giuseppe, additional, Pirovano, Alice, additional, Prosperini, Pierluigi, additional, Quaglino, Riccardo, additional, Rigamonti, Cristina, additional, Sainaghi, Pier Paolo, additional, Vecchi, Camilla, additional, Zecca, Erika, additional, and Pirisi, Mario, additional

Published
2021
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44. A scoping review of the epidemiological methods used to investigate the health effects of industrially contaminated sites

Author

De Sario, Manuela, Pasetto, Roberto, Vecchi, Simona, Zeka, Ariana, Hoek, Gerard, Michelozzi, Paola, Iavarone, Ivano, Fletcher, Tony, Bauleo, Lisa, Ancona, Carla, One Health Chemisch, dIRAS RA-2, and dIRAS RA-I&I RA

Subjects
study design, industrially contaminated sites, environmental epidemiology, residential exposure
Abstract

BACKGROUND: this paper is based upon work from COST Action ICSHNet. Industrial contaminated sites (ICSs) are of high concern since industrial plants have produced widespread contamination potentially affecting the health of local population OBJECTIVES: to assess the types of epidemiological designs applied in studies of health effects related to ICSs according to time periods, type of ICS, and geography. METHODS: a literature search was conducted in Medline (OVID) through June 30th, 2018, using MeSH and customized terms, and no restrictions on publication year or language. We included all studies throughout the world where a potential contamination of industrial origin occurred, an epidemiological approach (including biomonitoring, HBM) was applied, and health outcomes or exposure biomarkers among residents were investigated. Data on publication year, geographical localization and ICS characterization, study design (systematic reviews, cohort, case-control, temporal changes, cross-sectional, ecological, descriptive - area-level, case-series, narrative reviews, and HBM), and health outcomes were extracted from the abstracts. To check the sensitivity of the main search strategy, a case-study on Italy was conducted applying an ad-hoc search. RESULTS: from a literature search capturing 5,485 studies, 655 studies on resident populations were identified. The review includes more than 376 different ICSs, 86% from Europe, North America, and Asia combined, mostly dealing with nuclear sites and mining industries, waste and petrochemical activities. Most of the studies were descriptive (32.5%), cross-sectional (16.3%), or narrative review (14.8%), while analytical studies - case-control and cohort studies (9.6% and 8.4%, respectively) - were rarer; HBM were only 6.9%. A total of 235 studies, conducted mostly in Asia (34.5%), Europe (25.5%), and North America (22.3%), included children. The most frequently studied outcome was cancer (33.7%), followed by respiratory diseases (11.4%), and reproductive health (11.4%). The ad-hoc strategy greatly increased the number of detected papers (+122%). CONCLUSIONS: future research should adopt the most valid and suitable study design, according to the area-specific social and environmental context, also in areas of the world which are less studied, but with very high environmental worries of the resident population suffering the industrial contamination. Involvement of local experts on ICSs and local inventories are recommended to improve the coverage of the present inventory.

Published
2018

45. Revisione sistematica per valutare l’efficacia, l’accettabilità e la sicurezza degli antipsicotici di seconda generazione per il trattamento della depressione unipolare e bipolare

Author

Amato, Laura, Vecchi, Simona, Barbui, Corrado, Cruciani, Fabio, D'Amico, Roberto, Del Giovane, Cinzia, Minozzi, Silvia, Mitrova, Zuzana, Saulle, Rosella, and Davoli, Marina

Subjects
610 Medicine & health, 360 Social problems & social services
Abstract

BACKGROUND The World Health Organization (WHO) estimates that depression affects about 121 million people in the world and in terms of years of illness, by the year 2020 could become the second most prevalent disease in the world population after cardiovascular diseases. Second-generation antipsychotics (SGAs) seems to induce remission in depression when added to an antidepressant. AIM To evaluate the efficacy and safety of SGAs for the treatment of depression. METHODS We searched five bibliographic databases. We assessed the quality of evidence using Cochrane and GRADE criteria. RESULTS We included 42 RCTs. Where possible, we made a statistical synthesis of results. For efficacy outcomes, in direct comparisons in unipolar and bipolar patients with acute depressive episode, and in unipolar patients who did not respond to previous treatments with antidepressants (non-responders), SGAs gave better results than placebo, moderate to low certainty of evidence. In the comparison with antidepressants, in unipolar and bipolar patients with acute depressive episode the evidence was in favour of SGAs high certainty of evidence; while in the non-responder unipolar patients (the included studies considered only this typology of patients) the evidence was in favour of the antidepressants, low certainty of evidence. For safety outcomes, the results were in favour of placebo for patients with at least one adverse event, and in favour of SGAs for the number of patients with serious adverse events, for both comparisons the certainty of evidence was moderate. Comparing the SGAs with antidepressants, no differences were observed for patients with at least one adverse event, high certainty of evidence; while serious adverse events were less acute in patients treated with SGAs, moderate certainty evidence. The results of direct and indirect comparisons made with the network meta-analysis showed no differences for most of the outcomes considered, not showing a clear superiority of a drug compared to the others. CONCLUSIONS These results showed a moderate effect in favour of SGAs compared to antidepressants in patients, unipolar and bipolar, with a new acute depressive episode and confirm that in patients non-responders, antidepressants may remain more effective., Riassunto. Introduzione. L’Organizzazione Mondiale della Sanità (OMS) stima che la depressione colpisca circa 121 milioni di persone nel mondo e, entro il 2020, potrebbe diventare la seconda più diffusa patologia dopo le malattie cardiovascolari. Gli antipsicotici di seconda generazione (SGA), se associati a farmaci antidepressivi, sono stati segnalati come efficaci nell’indurre la remissione dei sintomi nei pazienti con depressione unipolare o bipolare. Obiettivo. Valutare l’efficacia e la sicurezza degli SGA per il trattamento della depressione. Metodo. Abbiamo eseguito una ricerca sistematica della letteratura in 5 database ed effettuato la valutazione della qualità metodologica utilizzando i criteri della Cochrane e la qualità delle prove utilizzando i criteri GRADE. Risultati. La presente revisione include 42 studi controllati randomizzati (RCT). I risultati sono stati cumulati, ove possibile, in sintesi statistiche. Per gli esiti relativi all’efficacia, nei confronti diretti nei pazienti unipolari e bipolari con episodio depressivo acuto e nei pazienti unipolari non rispondenti a precedenti trattamenti con antidepressivi (non responder), gli SGA davano risultati migliori del placebo, certezza delle prove da moderata a bassa. Nel confronto con gli antidepressivi, nei pazienti unipolari e bipolari con episodio depressivo acuto le prove erano in favore degli SGA con certezza delle prove alta; mentre nei pazienti unipolari non responder (gli studi non includevano pazienti bipolari) le prove erano in favore degli antidepressivi, certezza delle prove bassa. Per gli esiti relativi alla sicurezza, i risultati erano a favore del placebo per quanto attiene ai pazienti con almeno un evento avverso, e in favore degli SGA per il numero di pazienti con eventi avversi gravi, per entrambi i confronti la certezza delle prove era moderata. Confrontando gli SGA con gli antidepressivi, non sono state osservate differenze per quanto riguarda i pazienti con almeno un evento avverso, certezza delle prove alta; mentre gli eventi avversi gravi erano meno frequenti nei pazienti trattati con SGA, certezza delle prove moderata. I risultati dei confronti diretti e indiretti effettuati con la network meta-analisi non hanno rilevato differenze per la maggior parte degli esiti considerati, non evidenziando una chiara superiorità di un farmaco rispetto agli altri. Conclusioni. Questi risultati hanno mostrato un moderato effetto a favore degli SGA rispetto agli antidepressivi nei pazienti, unipolari e bipolari, con un nuovo episodio depressivo acuto e confermano che, nei pazienti non responder, gli antidepressivi possono rimanere più efficaci.

Published
2018
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49. Revisione sistematica per valutare l’efficacia, l’accettabilità e la sicurezza degli antipsicotici di seconda generazione per il trattamento della depressione unipolare e bipolare [Systematic review to evaluate the efficacy, acceptability and safety of second-generation antipsychotics for the treatment of unipolar and bipolar depression]

Author

Amato, Laura, Vecchi, Simona, Barbui, Corrado, Cruciani, Fabio, D'Amico, Roberto, Del Giovane, Cinzia, Minozzi, Silvia, Mitrova, Zuzana, Saulle, Rosella, and Davoli, Marina

Subjects
Depression, GRADE, network meta-analysis, second generation antipsychotics, network meta-analisi, Depressive Disorder, depressione, Bipolar Disorder, Antipsicotici di seconda generazione, Antidepressive Agents, Antipsychotic Agents, Humans, Randomized Controlled Trials as Topic, Treatment Outcome
Published
2018

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