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Objetivo: Analizar el perfil de los médicos de familia que accedieron a plazas, tanto del cupo general como reservadas para tutores de medicina familiar y comunitaria, mediante concurso de traslados. Material y métodos: Estudio observacional descriptivo. Se establecieron 2 grupos de comparación: en el grupo No Docencia se incluyeron médicos de familia que no solicitaron o no accedieron a plazas de tutoría y en el grupo Docencia, a los que accedieron a plazas reservadas para tutoría. La información se obtuvo de las puntuaciones del concurso de traslados realizado en Galicia en 2018. Se incluyeron 426 médicos de familia que se inscribieron en elconcurso: 301 mujeres (70,7%) y 125 hombres (29,3%). Las variables fueron la obtención deplaza con reserva para tutores, el género y los méritos considerados en el concurso: experiencia profesional, formación, publicaciones científicas y lengua gallega. Se utilizaron las pruebas estadísticas no paramétricas de Mann-Whitney y de Kruskal-Wallis, al comprobar la distribución no normal. Resultados: Se encontraron diferencias estadísticamente significativas en la distribución por géneros a favor de los hombres en el grupo Docencia frente al No Docencia, con una p < 0,01. El grupo Docencia obtuvo mejores resultados en formación y publicaciones. Las mujeres obtuvieron resultados estadísticamente significativos a su favor en la variable formación y los hombresen la experiencia. OBJECTIVE: To analyse the profile of Family Doctors who gain access to positions, both to the general quota, as well those reserved for teaching tutors of Family and Community Medicine, by means of a relocation competition. MATERIAL AND METHODS: A descriptive observational study was conducted in which 2 comparison groups were established: A Non-Teaching group that did not include Family Doctors who did not request or gain access to tutor positions, and a Teaching group with those that gained access to positions reserved for tutors. The information was obtained from the marks of the relocation competition carried out in Galicia in 2018. A total of 426 General Practitioners that entered the examination were included, of which 301 were female (70.7%) and 125 (29.3%) males. The variables were the obtaining of a position reserved for tutor, gender, and the merits considered in the competition: professional experience, training, scientific publications, and Galician language. The non-parametric statistics tests of Mann-Whitney and Kruskal-Wallis were used, after checking for non-normal distribution. RESULTS: Statistically significant differences were found in the distribution by gender in favour of males in the Teaching group compared to the Non-Teaching group (P

Submitted by Tauane Esteves (tauanefe@stj.jus.br) on 2018-07-12T17:13:39Z No. of bitstreams: 2 copa_mundo_naturalizacao_bueno.pdf: 534202 bytes, checksum: 3e7a8dd8dc376056de01723312d977b1 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Approved for entry into archive by Patrícia Rabello (rabello@stj.jus.br) on 2018-07-13T18:36:45Z (GMT) No. of bitstreams: 2 copa_mundo_naturalizacao_bueno.pdf: 534202 bytes, checksum: 3e7a8dd8dc376056de01723312d977b1 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Made available in DSpace on 2018-07-13T18:36:45Z (GMT). No. of bitstreams: 2 copa_mundo_naturalizacao_bueno.pdf: 534202 bytes, checksum: 3e7a8dd8dc376056de01723312d977b1 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Previous issue date: 2018

OBJECTIVES: The aim of this study was to develop a novel, self-administered questionnaire to identify primary-care physicians' knowledge and attitudes regarding antibiotics and resistance (KAAR). METHODS: The study population comprised primary care physicians. The study was conducted in five phases. Phase I consisted of a systematic review and qualitative focus-group study (n = 33 physicians), in which items were formulated so as to be measured on a continuous, visual analogue scale (VAS); in Phase II, content validation and face validity were evaluated by a panel of experts, which reformulated, added and deleted items; Phase III consisted of a pilot study on a population possessing similar characteristics (n = 15); in Phase IV, we analysed reliability by means of a test-retest study (n = 91) and calculated the intraclass correlation coefficients (ICCs); and in Phase V, we assessed construct validity by applying the known-groups technique, measuring the differences between contrasting groups of physicians formed according to antibiotic prescription quality indicators (group 1, n = 156 versus group 2, n = 191). RESULTS: Following Phases I and II, the questionnaire contained 16 knowledge and attitude items. Participants in the pilot study (Phase III) reported no difficulty. The test-retest study (Phase IV) showed that 11 of the 16 initial knowledge and attitude items yielded an ICC > 0.5, while analysis of known-groups validity (Phase V) showed that 13 of the 16 initial items which assessed knowledge and attitudes discriminated between physicians with good and bad indicators of antibiotics prescription. CONCLUSION: The final 11 item KAAR questionnaire appears to be valid, reliable and responsive. Instituto de Salud Carlos III FEDER Mutua Madrileña Insurance Company

Las resistencias a antibióticos son uno de los principales problemas de salud pública a nivel mundial, considerándose que el consumo inadecuado de antibióticos es el principal determinante de las mismas. Por tanto, una de las líneas de acción para reducirlas es mejorar la utilización de los antibióticos. Objetivo: Identificar qué actitudes de los médicos se asocian a la utilización inadecuada de antibióticos en Atención Primaria. Métodos: Se realizó un estudio de cohortes sobre una muestra de 3.675 médicos de Atención Primaria. Las variables independientes (actitudes) se valoraron mediante cuestionario postal autocumplimentado diseñado ad hoc. Como parte del diseño del cuestionario se realizó una revisión sistemática y un estudio cualitativo. Como variables dependientes se elaboraron indicadores de calidad de la prescripción de antibióticos a partir de las prescripciones reales de antibióticos de uso sistémico realizadas por los médicos estudiados. Para el análisis de los datos se utilizaron modelos lineales generales mixtos. Resultados: En las fases iniciales (revisión y estudio cualitativo) se identificaron cinco actitudes relacionadas con la utilización inadecuada de antibióticos: miedo, complacencia, falta de información, responsabilidad de otros e indiferencia. En el estudio de cohortes se confirmó que el miedo es la actitud más frecuentemente relacionada con la prescripción inadecuada. Conclusiones: Los resultados de este trabajo podrán ser usados para diseñar de forma específica intervenciones educativas dirigidas a médicos con la finalidad de modificar las actitudes asociadas a la utilización inadecuada de antibióticos en Atención Primaria. Tesis doctoral - Universidad de Santiago de Compostela. Facultad de Medicina. Departamento de Psiquiatria, Radiología y Salud Pública. Área de Medicina Preventiva y Salud Pública Tese doutoral - Universidade de Santiago de Compostela. Facultade de Medicina. Departamento de Psiquiatria, Radioloxía e Saúde Pública. Área de Medicina Preventiva e Saúde Pública Instituto de Salud Carlos III Fundación Mutua Madrileña

Tesis de Maestría

Submitted by Rafaella Monterei (rcarine@stj.jus.br) on 2016-04-04T17:06:25Z No. of bitstreams: 2 ilegitimidade_ativa_torcedor_vazquez.pdf: 593309 bytes, checksum: dd0e3c0852ccb955e0aa753f352ab644 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Approved for entry into archive by allanr@stj.jus.br (allanr@stj.jus.br) on 2016-05-02T20:05:08Z (GMT) No. of bitstreams: 2 ilegitimidade_ativa_torcedor_vazquez.pdf: 593309 bytes, checksum: dd0e3c0852ccb955e0aa753f352ab644 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Made available in DSpace on 2016-05-02T20:05:08Z (GMT). No. of bitstreams: 2 ilegitimidade_ativa_torcedor_vazquez.pdf: 593309 bytes, checksum: dd0e3c0852ccb955e0aa753f352ab644 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Previous issue date: 2014

Breast cancer progression and metastasis have been linked to abnormal signaling by transforming growth factor-beta (TGF-beta) cytokines. In early-stage breast cancers, TGF-beta exhibits tumor suppressor activity by repressing cell proliferation and inducing cell death, whereas in advanced-stage tumors, TGF-beta promotes invasion and metastatic dissemination. The molecular mechanisms underlying pro-oncogenic activities of TGF-beta are not fully understood. The present study validates the role of TGF-beta signaling in cancer progression and explores mediators of pro-oncogenic TGF-beta activities using the LM3 mammary adenocarcinoma cell line, derived from a spontaneous murine mammary adenocarcinoma. Expression of kinase-inactive TGF-beta receptors decreased both basal and TGF-beta-induced invasion. Analysis of signal transduction mediators showed that p38MAPK and MEK contribute to TGF-beta stimulation of cell motility and invasion. TGF-beta disrupted the epithelial actin structures supporting cell-cell adhesions, and increased linear actin filaments. Moreover, MEK and p38MAPK pathways showed opposite effects on actin remodeling in response to TGF-beta. Blockade of Raf-MEK signaling enhanced TGF-beta induction of actin stress-fibers whereas p38MAPK inhibitors blocked this effect. A novel observation was made that TGF-beta rapidly activates the actin nucleation Arp2/3 complex. In addition, TGF-beta stimulated matrix metalloproteinase MMP-9 secretion via a MAPK-independent pathway. Experiments using syngeneic mice showed that kinase-inactive TGF-beta receptors inhibit the first stages of LM3 tumor growth in vivo. Our studies demonstrate that autocrine TGF-beta signaling contributes to the invasive behavior of mammary carcinoma cells. Moreover, we show that both MAPK-dependent and -independent pathways are necessary for TGF-beta-induced effects. Therefore, MEK-ERK and p38 MAPK pathways are potential venues for therapeutic intervention in pro-oncogenic TGF-beta signaling. Fil: Daroqui, Maria Cecilia. Montefiore Medical Center; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Vazquez, Paula. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina Fil: Bal, Elisa Dora. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Bakin, Andrei V.. Roswell Park Cancer Institute; Estados Unidos Fil: Puricelli, Lydia I.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina

Submitted by Maria Helena Souza (mariahs@stj.jus.br) on 2014-10-21T16:18:55Z No. of bitstreams: 1 comentarios_decisao_judicial_delbin.pdf: 1226975 bytes, checksum: 9531c521c387d48b0e7ff958f7ab7fc7 (MD5) Made available in DSpace on 2014-10-21T16:18:55Z (GMT). No. of bitstreams: 1 comentarios_decisao_judicial_delbin.pdf: 1226975 bytes, checksum: 9531c521c387d48b0e7ff958f7ab7fc7 (MD5) Previous issue date: 2012