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2. Association of BMI, lipid-lowering medication, and age with prevalence of type 2 diabetes in adults with heterozygous familial hypercholesterolaemia: a worldwide cross-sectional study

Author

Elshorbagy, Amany, Lyons, Alexander R.M., Vallejo-Vaz, Antonio J., Stevens, Christophe A.T., Dharmayat, Kanika I., Brandts, Julia, Catapano, Alberico L., Freiberger, Tomas, Hovingh, G. Kees, Mata, Pedro, Raal, Frederick J., Santos, Raul D., Soran, Handrean, Watts, Gerald F., Abifadel, Marianne, Aguilar-Salinas, Carlos A., Alhabib, Khalid F., Alkhnifsawi, Mutaz, Almahmeed, Wael, Alonso, Rodrigo, Al-Rasadi, Khalid, Al-Sarraf, Ahmad, Ashavaid, Tester F., Banach, Maciej, Binder, Christoph J., Bourbon, Mafalda, Brunham, Liam R., Chlebus, Krzysztof, Corral, Pablo, Cruz, Diogo, Davletov, Kairat, Descamps, Olivier S., Ezhov, Marat, Gaita, Dan, Groselj, Urh, Harada-Shiba, Mariko, Holven, Kirsten B., Kayikcioglu, Meral, Khovidhunkit, Weerapan, Lalic, Katarina, Latkovskis, Gustavs, Laufs, Ulrich, Liberopoulos, Evangelos, Lima-Martinez, Marcos M., Lin, Jie, Maher, Vincent, Marais, A. David, März, Winfried, Mirrakhimov, Erkin, Miserez, André R., Mitchenko, Olena, Nawawi, Hapizah, Nordestgaard, Børge G., Panayiotou, Andrie G., Paragh, György, Petrulioniene, Zaneta, Pojskic, Belma, Postadzhiyan, Arman, Reda, Ashraf, Reiner, Željko, Reyes, Ximena, Sadiq, Fouzia, Sadoh, Wilson E., Schunkert, Heribert, Shek, Aleksandr B., Stroes, Erik, Su, Ta-Chen, Subramaniam, Tavintharan, Susekov, Andrey V., Tilney, Myra, Tomlinson, Brian, Truong, Thanh-Huong, Tselepis, Alexandros D., Tybjærg-Hansen, Anne, Vázquez, Alejandra C., Viigimaa, Margus, Vohnout, Branislav, Wang, Luya, Yamashita, Shizuya, Arca, Marcello, Averna, Maurizio, Schreier, Laura, Pang, Jing, Ebenbichler, Christoph, Dieplinger, Hans, Innerhofer, Reinhold, Winhofer-Stöckl, Yvonne, Greber-Platzer, Susanne, Krychtiuk, Konstantin, Speidl, Walter, Toplak, Hermann, Widhalm, Kurt, Stulnig, Thomas, Huber, Kurt, Höllerl, Florian, Rega-Kaun, Gersina, Kleemann, Lucas, Mäser, Martin, Scholl-Bürgi, Sabine, Säly, Christoph, Mayer, Florian J., Sperone, Alexandra, Tanghe, Chloé, Gérard, Anne-Catherine, Pojskic, Lamija, Sisic, Ibrahim, Durak Nalbantic, Azra, Ejubovic, Malik, Jannes, Cinthia E., Pereira, Alexandre C., Krieger, Jose E., Petrov, Ivo, Goudev, Assen, Nikolov, Fedya, Tisheva, Snejana, Yotov, Yoto, Tzvetkov, Ivajlo, Baass, Alexis, Bergeron, Jean, Bernard, Sophie, Brisson, Diane, Cermakova, Lubomira, Couture, Patrick, Francis, Gordon A., Gaudet, Daniel, Hegele, Robert A., Khoury, Etienne, Mancini, G.B. John, McCrindle, Brian W., Paquette, Martine, Ruel, Isabelle, Iatan, Iulia, Cuevas, Ada, Wang, Xumin, Meng, Kang, Song, Xiantao, Yong, Qiang, Jiang, Tao, Liu, Ziyou, Duan, Yanyu, Hong, Jing, Ye, Pucong, Chen, Yan, Qi, Jianguang, Liu, Zesen, Li, Yuntao, Zhang, Chaoyi, Peng, Jie, Yang, Ya, Yu, Wei, Wang, Qian, Yuan, Hui, Cheng, Shitong, Jiang, Long, Chong, Mei, Jiao, Jian, Wu, Yue, Wen, Wenhui, Xu, Liyuan, Zhang, Ruiying, Qu, Yichen, He, Jianxun, Fan, Xuesong, Wang, Zhenjia, Chow, Elaine, Pećin, Ivan, Perica, Dražen, Symeonides, Phivos, Vrablik, Michal, Ceska, Richard, Soska, Vladimir, Tichy, Lukas, Adamkova, Vera, Franekova, Jana, Cifkova, Renata, Kraml, Pavel, Vonaskova, Katerina, Cepova, Jana, Dusejovska, Magdalena, Pavlickova, Lenka, Blaha, Vladimir, Rosolova, Hana, Nussbaumerova, Barbora, Cibulka, Roman, Vaverkova, Helena, Cibickova, Lubica, Krejsova, Zdenka, Rehouskova, Katerina, Malina, Pavel, Budikova, Milena, Palanova, Vaclava, Solcova, Lucie, Lubasova, Alena, Podzimkova, Helena, Bujdak, Juraj, Vesely, Jiri, Jordanova, Marta, Salek, Tomas, Urbanek, Robin, Zemek, Stanislav, Lacko, Jan, Halamkova, Hana, Machacova, Sona, Mala, Sarka, Cubova, Eva, Valoskova, Katerina, Burda, Lukas, Benn, Marianne, Bendary, Ahmed, Daoud, Ihab, Emil, Sameh, Elbahry, Atef, Rafla, Samir, Sanad, Osama, Kazamel, Ghada, Ashraf, Dr Mohamed, Sobhy, Mohamed, El-Hadidy, Amro, Shafy, Mohamed Abdoul, Kamal, Saif, Bendary, Mohamed, Talviste, Grete, Christmann, Jutta, Dressel, Alexander, Fath, Felix, Ferraro, Chiara, Frenzke, Lydia, Gopon, Alica, Klein, Isabel, Pienkowska, Dominika, Sietmann, Tobias, Sonntag, Antonia, Adjan, Omar, Bahrmann, Philipp, Baessler, Andrea, Barkowski, Rasmus, Beckerdjian, Raffi, Berr, Christina, Birkenfeld, Andreas, Böll, Gereon, Carstensen, Avisha, Demuth, Ilya, Finkernagel, Holger, Gouni-Berthold, Ioanna, Hahmann, Harry, Hamerle, Michael, Halder, Julian, Heide, Maria, Julius, Ulrich, Kassner, Ursula, Katzmann, Julius L, Kirschbaum, Anja, Klose, Gerald, Könemann, Stephanie, König, Christel, König, Wolfgang, Krämer, Bernhard, Kuprat, Gerrit, Koschker, Ann-Cathrin, Kilic, Özlem, Lindenmeier, Gerd, Van de Loo, Iris, Lorenz, Babette, Lorenz, Elke, Löhr, Birgit, McChord, Johanna, Maslarska, Mariya, Methe, Heiko, Merkel, Martin, Moussaoui, Zineb, Müller-Kozarez, Irina, Olivier, Christoph B, Ong, Peter, Otte, Britta, Parhofer, Klaus, Partsch, Carl-Joachim, Paulus, Michael, Pehlivanli, Sinan, Pflederer, Tobias, Pusl, Thomas, Richter, Veronika, Rosner, Stefanie, Sanin, Veronika, Schäfer, Sebastian, Schäfer, Christoph, Schatz, Ulrike, Schirmer, Stephan, Schmidt, Christine, Seeger, Wolfgang, Sisovic, Snezna, Spens, Antje, Jablonski, Ksenija Stach, Stadelmann, Alexander, Steinhagen-Thiessen, Elisabeth, Stürzebecher, Paulina, Tafelmeier, Maria, Tillack, Dörthe, Tselmin, Sergey, Tünnemann-Tarr, Adrienn, Vogt, Anja, Beckerath, Jens von, Wilke, Andreas, Wolf, Ulrich, Zemmrich, Claudia, Rizos, Christos V., Skoumas, Ioannis, Tziomalos, Konstantinos, Rallidis, Loukianos, Kotsis, Vasileios, Doumas, Michalis, Athyros, Vasileios, Skalidis, Emmanouil, Kolovou, Genovefa, Kolovou, Vana, Garoufi, Anastasia, Bilianou, Eleni, Koutagiar, Iosif, Kiouri, Estela, Antza, Christina, Zacharis, Evangelos, Attilakos, Achilleas, Sfikas, George, Koumaras, Charalambos, Anagnostis, Panagiotis, Anastasiou, Georgia, Liamis, George, Koutsogianni, Amalia-Despoina, Petkou, Ermioni, Milionis, Haralambos, Koulouri, Anastasia, Prodromiadou, Elisavet, Karányi, Zsolt, Harangi, Mariann, Bajnok, László, Audikovszky, Mária, Márk, László, Benczúr, Béla, Reiber, István, Nagy, Gergely, Nagy, András, Reddy, Lakshmi Lavanya, Shah, Swarup A. V, Ponde, Chandrashekhar K., Dalal, Jamshed J., Sawhney, Jitendra P.S., Verma, Ishwar C., Altaey, Mays, Al-Jumaily, Khalid, Rasul, Dilshad, Abdalsahib, Ali Fawzi, Jabbar, Amer Abdl, Al-ageedi, Mohanad, Dhamin, Mohammed, AlFil, Sarmad, Khadhim, Foad, Miahy, Sabah, Agar, Ruth, Catapano, Alberico Luigi, Calandra, Sebastiano, Tarugi, Patrizia, Casula, Manuela, Galimberti, Federica, Olmastroni, Elena, Sarzani, Riccardo, Ferri, Claudio, Repetti, Elena, Piro, Salvatore, Suppressa, Patrizia, Meregalli, Giancarla, Borghi, Claudio, Muntoni, Sandro, Calabrò, Paolo, Cipollone, Francesco, Purrello, Francesco, Pujia, Arturo, Passaro, Angelina, Marcucci, Rossella, Pecchioli, Valerio, Pisciotta, Livia, Mandraffino, Giuseppe, Pellegatta, Fabio, Mombelli, Giuliana, Branchi, Adriana, Fiorenza, Anna Maria, Pederiva, Cristina, Werba, Josè Pablo, Parati, Gianfranco, Carubbi, Francesca, Iughetti, Lorenzo, Fortunato, Giuliana, Iannuzzi, Arcangelo, Iannuzzo, Gabriella, Cefalù, Angelo Baldassare, Biasucci, Giacomo, Zambon, Sabina, Pirro, Matteo, Sbrana, Francesco, Trenti, Chiara, D'Erasmo, Laura, Federici, Massimo, Ben, Maria Del, Bartuli, Andrea, Giaccari, Andrea, Pipolo, Antonio, Citroni, Nadia, Guardamagna, Ornella, Lia, Salvatore, Benso, Andrea, Biolo, Gianni, Maroni, Lorenzo, Lupi, Alessandro, Bonanni, Luca, Rinaldi, Elisabetta, Zenti, Maria Grazia, Matsuki, Kota, Hori, Mika, Ogura, Masatsune, Masuda, Daisaku, Kobayashi, Takuya, Nagahama, Kumiko, Al-Jarallah, Mohammed, Radovic, Mirjana, Lunegova, Olga, Bektasheva, Erkayim, Abilova, Saamay, Erglis, Andrejs, Gilis, Dainus, Nesterovics, Georgijs, Saripo, Vita, Meiere, Ruta, Skudrina, Gunda, Terauda, Elizabete, Jambart, Selim, Ayoub, Carine, Ghaleb, Youmna, Aliosaitiene, Urte, Kutkiene, Sandra, Abdul Kadir, Siti Hamimah Sheikh, Kasim, Noor Alicezah Mohd, Nor, Noor Shafina Mohd, Abdul Hamid, Hasidah, Abdul Razak, Suraya, Al-Khateeb, Alyaa, Abd Muid, Suhaila, Abdul Rahman, Thuhairah, Kasim, Sazzli Shahlan, Radzi, Ahmad Bakhtiar Md, Ibrahim, Khairul Shafiq, Rosli, Marshima Mohd, Razali, Rafezah, Chua, Yung An, Razman, Aimi Zafira, Nazli, Sukma Azureen, Aziz, Nazirul, Rosman, Azhari, Abdul Murad, NorAzian, Jalaludin, Mohd Amin, Abdul Latif, Ahmad Zubaidi, Azzopardi, C., Mehta, Roopa, Martagon, Alexandro J., Ramirez, Gabriela A. Galan, Villa, Neftali E Antonio, Vazquez, Arsenio Vargas, Elias-Lopez, Daniel, Retana, Gustavo Gonzalez, Rodriguez, Betsabel, Macías, Jose J. Ceballos, Zazueta, Alejandro Romero, Alvarado, Rocio Martinez, Portano, Julieta D. Morales, Lopez, Humberto Alvares, Sauque-Reyna, Leobardo, Herrera, Laura G. Gomez, Mendia, Luis E. Simental, Aguilar, Humberto Garcia, Cooremans, Elizabeth Ramirez, Aparicio, Berenice Peña, Zubieta, Victoria Mendoza, Gonzalez, Perla A. Carrillo, Ferreira-Hermosillo, Aldo, Portilla, Nacu Caracas, Dominguez, Guadalupe Jimenez, Garcia, Alinna Y. Ruiz, Cazares, Hector E. Arriaga, Gonzalez, Jesus R., Valencia, Carla V. Mendez, Padilla, Francisco G., Prado, Ramon Madriz, Ibarra, Manuel O. De los Rios, Villicaña, Ruy D. Arjona, Rivera, Karina J. Acevedo, Carrera, Ricardo Allende, Alvarez, Jose A., Martinez, Jose C. Amezcua, Bustillo, Manuel de los Reyes Barrera, Vargas, Gonzalo Carazo, Chacon, Roberto Contreras, Andrade, Mario H. Figueroa, Ortega, Ashanty Flores, Alcala, Hector Garcia, de Leon, Laura E. Garcia, Guzman, Berenice Garcia, Garcia, Jose J. Garduño, Cuellar, Juan C. Garnica, Cruz, Jose R. Gomez, Garcia, Anell Hernandez, Almada, Jesus R. Holguin, Herrera, Ursulo Juarez, Sobrevilla, Fabiola Lugo, Rodriguez, Eduardo Marquez, Sibaja, Cristina Martinez, Rodriguez, Alma B. Medrano, Oyervides, Jose C. Morales, Vazquez, Daniel I. Perez, Rodriguez, Eduardo A. Reyes, Osorio, Ma. Ludivina Robles, Saucedo, Juan Rosas, Tamayo, Margarita Torres, Talavera, Luis A. Valdez, Arroyo, Luis E. Vera, Carrillo, Eloy A. Zepeda, Stroes, Erik S, Defesche, J, Zuurbier, L, Reeskamp, L, Ibrahim, S, Roeters van Lennep, Jeanine, Wiegman, Albert, Isara, Alphonsus, Obaseki, Darlington E., Al-Waili, Khalid, Al-Zadjali, Fahad, Al-Zakwani, Ibrahim, Al-Kindi, Mohammed, Al-Mukhaini, Suad, Al-Barwani, Hamida, Rana, Asim, Shah, Lahore Saeed Ullah, Al-Nouri, Fahad, Starostecka, Ewa, Konopka, Agnieszka, Bielecka-Dabrowa, Agata, Lewek, Joanna, Sosnowska, Bozena, Gąsior, Mariusz, Dyrbuś, Krzysztof, Jóźwiak, Jacek, Pajkowski, Marcin, Romanowska-Kocejko, Marzena, Żarczyńska-Buchowiecka, Marta, Chmara, Magdalena, Wasąg, Bartosz, Stróżyk, Aneta, Michalska-Grzonkowska, Aleksandra, Medeiros, Ana Margarida, Alves, Ana Catarina, Silva, Francisco, Lobarinhas, Goreti, Palma, Isabel, de Moura, Jose Pereira, Rico, Miguel Toscano, Rato, Quitéria, Pais, Patrícia, Correia, Susana, Moldovan, Oana, Virtuoso, Maria João, Araujo, Francisco, Salgado, Jose Miguel, Colaço, Ines, Dumitrescu, Andreea, Lengher, Calin, Mosteoru, Svetlana, Meshkov, Alexey, Ershova, Alexandra, Rozhkova, Tatiana, Korneva, Victoria, Yu, Kuznetsova T., Zafiraki, Vitaliy, Voevoda, Mikhail, Gurevich, Victor, Duplyakov, Dmitry, Ragino, Yulia, Chubykina, Uliana, Shaposhnik, Igor, Alkaf, Fahmi, Khudari, Alia, Rwaili, Nawal, Al-Allaf, Faisal, Alghamdi, Mohammad, Batais, Mohammed A, Almigbal, Turky H, Kinsara, Abdulhalim, AlQudaimi, Ashraf Hammouda Ahmed, Awan, Zuhier, Elamin, Omer A, Altaradi, Hani, Popovic, Ljiljana, Singh, Sandra, Rasulic, Iva, Petakov, Ana, Lalic, Nebojsa M., Lam, Carolyn, Le, Tan Ju, Siang, Eric Lim Tien, Dissanayake, Sanjaya, I-Shing, Justin Tang, Shyong, Tai E, Jin, Terrance Chua Siang, Ting, Sharon Pek Li, Ming, Jeremy Hoe Kian, Drum, Chester Lee, Nastar, Fathima Ashna, Jia, Loh Wann, Ya, Natalie Koh Si, Jie, Marvin Chua Wei, Dalan, Rinkoo, Wei, Yong Quek, sian, Tiong Yee, Keong, Yeo Khung, Rong, Siau Kai, Jin, Darren Seah Ee, Ming, Ian Koh Jan, Chang, Tan Hong, Peng, Fabian Yap Kok, Vasanwala, Rashida Farhad, Raslova, Katarina, Balinth, Karin, Buganova, Ingrid, Fabryova, Lubomira, Kadurova, Michaela, Klabnik, Alexander, Kozárová, Miriam, Sirotiakova, Jana, Battelino, Tadej, Cevc, Matija, Debeljak, Marusa, Torkar, Ana Drole, Fras, Zlatko, Jug, Borut, Cugalj, Barbara Kern, Kovac, Jernej, Mlinaric, Matej, Sikonja, Jaka, Pilcher, Gillian Joan, Blom, D J, Wolmarans, K H, Brice, B C, Muñiz-Grijalvo, Ovidio, Díaz-Díaz, Jose Luis, de Isla, Leopoldo Pérez, Fuentes, Francisco, Badimon, Lina, Martin, François, Miserez, Eleonore B., Shipton, Janine L., Ganokroj, Poranee, Chattranukulchai, Pairoj, Jiamjarasrungsi, Wiroj, Thongtang, Nuntakorn, Krittayaphong, Rungroj, Vathesatogkit, Prin, Sriphrapradang, Chutintorn, Phimphilai, Mattabhorn, Leelawattana, Rattana, Anthanont, Pimjai, Suraamornkul, Swangjit, Deerochanawong, Chaicharn, Senthong, Vichai, Torpongpun, Artit, Suteerayongprasert, Panuwat, Pengpong, Nawarat, Sathavarodom, Nattapol, Sunanta, Usanee, Porntharukchareon, Thachanun, Kiatpanabhikul, Phatharaporn, Kaewkrasaesin, Chatchon, Kongkit, Jaruwan, Umphonsathien, Mongkontida, Akbulut, Mehmet, Alici, Gökhan, Bayram, Fahri, Can, Levent Hürkan, Celik, Ahmet, Ceyhan, Ceyhun, Coskun, Fatma Yilmaz, Demir, Mesut, Demircan, Sabri, Dogan, Volkan, Durakoglugil, Emre, Dural, İbrahim Etem, Gedikli, Omer, Hacioglu, Aysa, Ildizli, Muge, Kilic, Salih, Kirilmaz, Bahadir, Kutlu, Merih, Oguz, Aytekin, Ozdogan, Oner, Onrat, Ersel, Ozer, Savas, Sabuncu, Tevfik, Sahin, Tayfun, Sivri, Fatih, Sonmez, Alper, Temizhan, Ahmet, Topcu, Selim, Tokgozoglu, Lale, Tuncez, Abdullah, Vural, Mirac, Yenercag, Mustafa, Yesilbursa, Dilek, Yigit, Zerrin, Yildirim, Aytul Belgi, Yildirir, Aylin, Yilmaz, Mehmet Birhan, Atallah, Bassam, Traina, Mahmoud, Sabbour, Hani, Abdul Hay, Dana, Luqman, Neama, Elfatih, Abubaker, Abdulrasheed, Arshad, Manla, Yosef, Kwok, See, DellOca, Nicolas, Alieva, Rano B., Fozilov, Khurshid G., Hoshimov, Shavkat U., Nizamov, Ulugbek I., Kan, Liliya E., Kim, Andrey R., Abdullaeva, Guzal J., Abdullaev, Alisher A., Do, Doan Loi, Nguyen, Mai Ngoc Thi, Kim, Ngoc Thanh, Le, Thanh Tung, Le, Hong An, and Ray, Kausik K.

Published
2024
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3. The Transcriptomic Portrait of Locally Advanced Breast Cancer and Its Prognostic Value in a Multi-Country Cohort of Latin American Patients

Author

Llera, Andrea Sabina, Abdelhay, Eliana Saul Furquim Werneck, Artagaveytia, Nora, Daneri-Navarro, Adrián, Müller, Bettina, Velazquez, Carlos, Alcoba, Elsa B, Alonso, Isabel, da Quinta, Daniela B Alves, Binato, Renata, Bravo, Alicia Inés, Camejo, Natalia, Carraro, Dirce Maria, Castro, Mónica, Castro-Cervantes, Juan M, Cataldi, Sandra, Cayota, Alfonso, Cerda, Mauricio, Colombo, Alicia, Crocamo, Susanne, Del Toro-Arreola, Alicia, Delgadillo-Cisterna, Raúl, Delgado, Lucía, Dreyer-Breitenbach, Marisa, Fejerman, Laura, Fernández, Elmer A, Fernández, Jorge, Fernández, Wanda, Franco-Topete, Ramón A, Gabay, Carolina, Gaete, Fancy, Garibay-Escobar, Adriana, Gómez, Jorge, Greif, Gonzalo, Gross, Thomas G, Guerrero, Marisol, Henderson, Marianne K, Lopez-Muñoz, Miguel E, Lopez-Vazquez, Alejandra, Maldonado, Silvina, Morán-Mendoza, Andrés J, Nagai, Maria Aparecida, Oceguera-Villanueva, Antonio, Ortiz-Martínez, Miguel A, Quintero, Jael, Quintero-Ramos, Antonio, Reis, Rui M, Retamales, Javier, Rivera-Claisse, Ernesto, Rocha, Darío, Rodríguez, Robinson, Rosales, Cristina, Salas-González, Efrain, Sanchotena, Verónica, Segovia, Laura, Sendoya, Juan Martín, Silva-García, Aida A, Trinchero, Alejandra, Valenzuela, Olivia, Vedham, Vidya, Zagame, Livia, Network, States-Latin American Cancer Research, Podhajcer, Osvaldo L, Abarca, Juan, Acevedo, Pamela, Acosta, Graciela, Acosta, Gissel, Haab, Gabriela Acosta, Silva, Ana Lilian Acosta, Aghazarian, Marta, Aguayo, Carola, Aizen, Bernardo, Lopez, Gustavo Alarcon, Almeida, Liz, Alvarez, Ana, Andrade, Viviane, Angeles-Bueno, Wenceslao, Arai, Roberto, Barreras, Priscila Elvira Arambula, Rubio, Ma Isabel Aramburo, Ardao, Gonzalo, Arellano-Jimenez, Lilia A, Arias, Claudia, Armisen, Ricardo, Aspee, Mauricio, Assar, Rodrigo, Rascón, Itzel Rene xe9 Astiazar xe1 N, Astorga, Sebastian, Rodriguez, Maxwell Aviles, Bailão, Ant xf4 nio, Barragan-Curiel, Adolfo E, Barragan-Ruiz, Adelfo, Bermudez, Fernanda, Bernachin, Julia, Herrera, Wilfrido Bernal, Bonet, Mara, Brnich, Sarah, Bustamante, Claudio, Bustamante, Miguel Angel, and Bustos-Gomez, Julio

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Breast Cancer, Cancer, Genetics, breast cancer, Latin America, PAM50 subtypes, risk of recurrence, biological pathways, United States-Latin American Cancer Research Network, Clinical sciences, Oncology and carcinogenesis
Abstract

PurposesMost molecular-based published studies on breast cancer do not adequately represent the unique and diverse genetic admixture of the Latin American population. Searching for similarities and differences in molecular pathways associated with these tumors and evaluating its impact on prognosis may help to select better therapeutic approaches.Patients and methodsWe collected clinical, pathological, and transcriptomic data of a multi-country Latin American cohort of 1,071 stage II-III breast cancer patients of the Molecular Profile of Breast Cancer Study (MPBCS) cohort. The 5-year prognostic ability of intrinsic (transcriptomic-based) PAM50 and immunohistochemical classifications, both at the cancer-specific (OSC) and disease-free survival (DFS) stages, was compared. Pathway analyses (GSEA, GSVA and MetaCore) were performed to explore differences among intrinsic subtypes.ResultsPAM50 classification of the MPBCS cohort defined 42·6% of tumors as LumA, 21·3% as LumB, 13·3% as HER2E and 16·6% as Basal. Both OSC and DFS for LumA tumors were significantly better than for other subtypes, while Basal tumors had the worst prognosis. While the prognostic power of traditional subtypes calculated with hormone receptors (HR), HER2 and Ki67 determinations showed an acceptable performance, PAM50-derived risk of recurrence best discriminated low, intermediate and high-risk groups. Transcriptomic pathway analysis showed high proliferation (i.e. cell cycle control and DNA damage repair) associated with LumB, HER2E and Basal tumors, and a strong dependency on the estrogen pathway for LumA. Terms related to both innate and adaptive immune responses were seen predominantly upregulated in Basal tumors, and, to a lesser extent, in HER2E, with respect to LumA and B tumors.ConclusionsThis is the first study that assesses molecular features at the transcriptomic level in a multicountry Latin American breast cancer patient cohort. Hormone-related and proliferation pathways that predominate in PAM50 and other breast cancer molecular classifications are also the main tumor-driving mechanisms in this cohort and have prognostic power. The immune-related features seen in the most aggressive subtypes may pave the way for therapeutic approaches not yet disseminated in Latin America.Clinical trial registrationClinicalTrials.gov (Identifier: NCT02326857).

Published
2022

4. Building Academic Confidence in English Language Learners in Elementary School

Author

Vazquez, Alejandra

Abstract

Non-English speaking students lack the confidence and preparation to be verbally actively engaged in the classroom. Students may frequently display hesitation in learning to speak English, and may also lack a teacher's guidance in becoming proficient English speakers. The purpose of this research is to examine how teachers build academic confidence in English language learners. This study also examines how teachers can develop active and confident English speaking students, and improve home-school communication. Research questions include the following: What are factors that contribute to confidence among ELL students in gaining English fluency? How can classroom teachers help develop self-confidence in ELL students? How can classroom teachers enhance home-school communication with families whose primary language is not English? The research approach includes gathering peer-reviewed information from articles, journals, and online databases. Additionally, a qualitative study is designed where several teachers were purposely selected to participate in a one-hour interview. Secondly, parents of children in a Spanish speaking community are being asked to participate in a focus group that addressed communication issues between home and school. Interview questions are appended.

Published
2014

6. Reshaping policy : creativity and everyday practice in an arts organisation in Mexico City

Author

Jaramillo-Vazquez, Alejandra

Subjects
707.1
Abstract

This research is concerned with how policy becomes practice. It examines the ways by which a policy is reshaped through its encounter with people, architecture and facilities, documents and specific realisations in art projects. In particular, it is concerned with how a left-wing arts education policy, one that aimed to emancipate disadvantaged people, worked in practice – including how it sometimes ended up running counter to its stated aims. The policies that are followed here were first devised by the Leftist government in Mexico City between 1997 and 2000, and then expanded through various revisions and new policies in the following years. As part of the initial policy, an arts organisation, Faro de Oriente – Lighthouse of the Orient – was constructed in a deprived area in the East of Mexico City to give ‘access’ to ‘arts’ and opportunities for ‘creativity’ for the local population. This thesis provides an in-depth study of how this specific arts policy was experienced on the ground between 2011-12 by the various participants in FARO –permanent staff, temporary teaching staff and also students who participated in arts workshops. Based on extensive ethnographic fieldwork, including participant observation, interviews, archival research, and photographic documentation, the thesis charts the ways in which particular aspects of the policy were mobilised and to what ends, and how these were reshaped through practice. This thesis highlights the significance not only of intentional actions by people but also of implements of work, such as the architecture of the FARO main building and its physical condition, the role of teaching staff and artistic projects. Inspired by actor-network and assemblage theory which emphasise the interactions of human with non-human actors and processes that shape entities, the thesis maintains that a policy concerning arts education and creativity refers to the processes, practices and meanings of creativity that participants produce at FARO through everyday practice. A policy is an unfinished social process shaped by technical concepts, materialities, implements and reshaped through the practices of participants. Empirically, this research provides understanding of the everyday dynamics inside FARO, highlighting contradictions and ambiguities for the experience of students. This thesis contributes to debates suttounding policy and creativity through the processes of the everyday life in an arts organisation.

Published
2015

11. Socioeconomic, Clinical, and Molecular Features of Breast Cancer Influence Overall Survival of Latin American Women

Author

de Almeida, Liz María, Cortés, Sandra, Vilensky, Marta, Valenzuela, Olivia, Cortes-Sanabria, Laura, de Souza, Mirian, Barbeito, Rafael Alonso, Abdelhay, Eliana, Artagaveytia, Nora, Daneri-Navarro, Adrian, Llera, Andrea Sabina, Müller, Bettina, Podhajcer, Osvaldo, Velazquez, Carlos, Alcoba, Elsa, Alonso, Isabel, Bravo, Alicia I., Camejo, Natalia, Carraro, Dirce María, Castro, Mónica, Cataldi, Sandra, Cayota, Alfonso, Cerda, Mauricio, Colombo, Alicia, Crocamo, Susanne, Del Toro-Arreola, Alicia, Delgadillo-Cristerna, Raúl, Delgado, Lucía, Breitenbach, Marisa Dreyer, Fernández, Elmer Andrés, Fernández, Jorge, Fernández, Wanda, Franco-Topete, Ramón A., Gaete, Fancy, Gómez, Jorge, Gonzalez-Ramirez, Leivy P., Guerrero, Marisol, Gutierrez-Rubio, Susan A., Jalfin, Beatriz, Lopez-Vazquez, Alejandra, Loria, Dora, Míguez, Silvia, Moran-Mendoza, Andrés de J., Morgan-Villela, Gilberto, Mussetti, Carina, Nagai, Maria Aparecida, Oceguera-Villanueva, Antonio, Reis, Rui M., Retamales, Javier, Rodriguez, Robinson, Rosales, Cristina, Salas-Gonzalez, Efrain, Segovia, Laura, Sendoya, Juan M., Silva-Garcia, Aida A., Viña, Stella, Zagame, Livia, Jones, Beth, Szklo, Moysés, de Almeida, Liz María, Cortés, Sandra, Vilensky, Marta, Valenzuela, Olivia, Cortes-Sanabria, Laura, de Souza, Mirian, Barbeito, Rafael Alonso, Abdelhay, Eliana, Artagaveytia, Nora, Daneri-Navarro, Adrian, Llera, Andrea Sabina, Müller, Bettina, Podhajcer, Osvaldo, Velazquez, Carlos, Alcoba, Elsa, Alonso, Isabel, Bravo, Alicia I., Camejo, Natalia, Carraro, Dirce María, Castro, Mónica, Cataldi, Sandra, Cayota, Alfonso, Cerda, Mauricio, Colombo, Alicia, Crocamo, Susanne, Del Toro-Arreola, Alicia, Delgadillo-Cristerna, Raúl, Delgado, Lucía, Breitenbach, Marisa Dreyer, Fernández, Elmer Andrés, Fernández, Jorge, Fernández, Wanda, Franco-Topete, Ramón A., Gaete, Fancy, Gómez, Jorge, Gonzalez-Ramirez, Leivy P., Guerrero, Marisol, Gutierrez-Rubio, Susan A., Jalfin, Beatriz, Lopez-Vazquez, Alejandra, Loria, Dora, Míguez, Silvia, Moran-Mendoza, Andrés de J., Morgan-Villela, Gilberto, Mussetti, Carina, Nagai, Maria Aparecida, Oceguera-Villanueva, Antonio, Reis, Rui M., Retamales, Javier, Rodriguez, Robinson, Rosales, Cristina, Salas-Gonzalez, Efrain, Segovia, Laura, Sendoya, Juan M., Silva-Garcia, Aida A., Viña, Stella, Zagame, Livia, Jones, Beth, and Szklo, Moysés

Abstract

Molecular profile of breast cancer in Latin-American women was studied in five countries: Argentina, Brazil, Chile, Mexico, and Uruguay. Data about socioeconomic characteristics, risk factors, prognostic factors, and molecular subtypes were described, and the 60-month overall cumulative survival probabilities (OS) were estimated. From 2011 to 2013, 1,300 eligible Latin-American women 18 years or older, with a diagnosis of breast cancer in clinical stage II or III, and performance status ≦̸1 were invited to participate in a prospective cohort study. Face-to-face interviews were conducted, and clinical and outcome data, including death, were extracted from medical records. Unadjusted associations were evaluated by Chi-squared and Fisher’s exact tests and the OS by Kaplan–Meier method. Log-rank test was used to determine differences between cumulative probability curves. Multivariable adjustment was carried out by entering potential confounders in the Cox regression model. The OS at 60 months was 83.9%. Multivariable-adjusted death hazard differences were found for women living in Argentina (2.27), Chile (1.95), and Uruguay (2.42) compared with Mexican women, for older (≥60 years) (1.84) compared with younger (≤40 years) women, for basal-like subtype (5.8), luminal B (2.43), and HER2-enriched (2.52) compared with luminal A subtype, and for tumor clinical stages IIB (1.91), IIIA (3.54), and IIIB (3.94) compared with stage IIA women. OS was associated with country of residence, PAM50 intrinsic subtype, age, and tumor stage at diagnosis. While the latter is known to be influenced by access to care, including cancer screening, timely diagnosis and treatment, including access to more effective treatment protocols, it may also influence epigenetic changes that, potentially, impact molecular subtypes. Data derived from heretofore understudied populations with unique geographic ancestry and sociocultural experiences are critical to furthering our understanding of this complexi, Fil: de Almeida, Liz Maria. Instituto Nacional de Cáncer; Brasil, Fil: Cortés, Sandra. Pontificia Universidad Católica de Chile; Chile, Fil: Vilensky, Marta. Instituto de Oncología Angel Roffo; Argentina, Fil: Valenzuela, Olivia. Universidad de Sonora; México, Fil: Cortes-Sanabria, Laura. Hospital de Especialidades, CMNO-IMSS; México, Fil: de Souza, Mirian. Instituto Nacional de Cáncer; Brasil, Fil: Barbeito, Rafael Alonso. Facultad de Medicina; Argentina, Fil: Abdelhay, Eliana. Instituto Nacional de Cáncer; Brasil, Fil: Artagaveytia, Nora. Hospital de Clínicas Manuel Quintela. Universidad de la República; Uruguay, Fil: Daneri-Navarro, Adrian. Universidad de Guadalajara; México, Fil: Llera, Andrea S. CONICET. Fundación Instituto Leloir; Argentina, Fil: Müller, Bettina. Instituto Nacional del Cáncer; Argentina, Fil: Podhajcer, Osvaldo L. CONICET. Fundación Instituto Leloir; Argentina, Fil: Velazquez, Carlos. Universidad de Sonora; México, Fil: Alcoba, Elsa. Hospital Municipal de Oncología María Curie; Argentina, Fil: Alonso, Isabel. Centro Hospitalario Pereira Rossell; Argentina, Fil: Bravo, Alicia I. Hospital Regional de Agudos Eva Perón; Argentina, Fil: Camejo, Natalia. Hospital de Clínicas Manuel Quintela. Universidad de la República; Uruguay, Fil: Carraro, Dirce Maria. AC Camargo Cancer Center; Brasil, Fil: Castro, Mónica. Instituto de Oncología Angel Roffo; Argentina, Fil: Cataldi, Sandra. Instituto Nacional de Cáncer; Uruguay, Fil: Cayota, Alfonso. Institut Pasteur de Montevideo; Uruguay, Fil: Cerda, Mauricio. Universidad de Chile; Chile, Fil: Colombo, Alicia. Universidad de Chile; Chile, Fil: Crocamo, Susanne. Instituto Nacional de Cáncer; Brasil, Fil: Del Toro-Arreola, Alicia. Universidad de Guadalajara; México, Fil: Delgadillo-Cristerna, Raul. Hospital de Especialidades. CMNO-IMSS; México, Fil: Delgado, Lucia. Hospital de Clínicas Manuel Quintela; Uruguay, Fil: Breitenbach, Marisa Dreyer. Universidade do Estado do Rio de Janeiro; Brasil, Fil: Fernández, Elmer. Universidad Católica de Córdoba. CONICET. Centro de Investigaciones en Bioquímica Clínica e Inmunologia; Argentina, Fil: Fernández, Jorge. Instituto de Salud Pública; Chile, Fil: Fernández, Wanda. Hospital San Borja Arriarán; Chile, Fil: Franco-Topete, Ramon A. OPD Hospital Civil de Guadalajara. Universidad de Guadalajara; México, Fil: Gaete, Fancy. Hospital Luis Tisne; Chile, Fil: Gómez, Jorge. Texas A&M University; Estados Unidos, Fil: Gonzalez-Ramirez, Leivy P. Universidad de Guadalajara; México, Fil: Guerrero, Marisol. Hospital San José; Chile, Fil: Gutierrez-Rubio, Susan A. Universidad de Guadalajara; México, Fil: Jalfin, Beatriz. Hospital Regional de Agudos Eva Perón; Argentina, Fil: Lopez-Vazquez, Alejandra. Universidad de Sonora; México, Fil: Loria, Dora. Instituto de Oncología Angel Roffo; Argentina, Fil: Míguez, Silvia. Hospital Municipal de Oncología María Curie; Argentina, Fil: Moran-Mendoza, Andres de J. Hospital de Gineco-Obstetricia CMNO-IMSS; México, Fil: Morgan-Villela, Gilberto. Hospital de Especialidades. CMNO-IMSS; México, Fil: Mussetti, Carina. Registro Nacional de Cancer; Uruguay, Fil: Nagai, Maria Aparecida. Instituto de Câncer de São Paulo; Brasil, Fil: Oceguera-Villanueva, Antonio. Instituto Jalisciense de Cancerologia; México, Fil: Reis, Rui M. Hospital de Câncer de Barretos; Brasil, Fil: Retamales, Javier. Grupo Oncológico Cooperativo Chileno de Investigación; Chile, Fil: Rodriguez, Robinson. Hospital Central de las Fuerzas Armadas; Uruguay, Fil: Rosales, Cristina, Hospital Municipal de Oncología María Curie; Argentina, Fil: Salas-Gonzalez, Efrain. Hospital San José; Chile, Fil: Segovia, Laura. Hospital Barros Luco Trudeau; Chile, Fil: Sendoya, Juan M. CONICET. Fundación Instituto Leloir,; Argentina, Fil: Silva-Garcia, Aida A. OPD Hospital Civil de Guadalajara. Universidad de Guadalajara; México, Fil: Viña, Stella. Instituto de Oncología Angel Roffo; Argentina, Fil: Zagame, Livia. Instituto Jalisciense de Cancerologia; México, Fil: Jones, Beth. Yale University. Yale School of Public Health; Estados Unidos, Fil: Szklo, Moysés. Johns Hopkins University. Johns Hopkins Bloomberg School of Public Health; Estados Unidos

Published
2022

16. Plan de negocios para la creación de una plataforma para el servicio turístico

Author

Vargas Vazquez, Alejandra, Alarcon Alfaro, Juan Carlos, Olacua Moreno, Marco Antonio, Suárez Mendoza, Andrés Gustavo, Pardo D'Ornellas, Enrique Jose, Benzaquen de las Casas, Jorge Benny, and Benzaquen De Las Casas, Jorge Benny

Subjects
Realidad virtual, Plan de negocios, Turismo, purl.org/pe-repo/ocde/ford#5.02.04 [https]
Abstract

Muchas empresas del sector turístico en la actualidad han implementado el uso de realidad virtual como medio para superar la crisis económico generada por la pandemia; mediante la digitalización se han permitido llegar a más lugares y mantenerse en el mercado. Los recorridos virtuales en esta plataforma tienen el plus de poder ser sincrónico y contar con un guía para cada sesión. El viaje virtual se puede personalizar, con una mayor complejidad en su ejecución, ya que se deben definir horarios, con un el plus de poder ser más personalizado. Es así que, VR TOURS PERÚ, tiene como objetivo brindar un paquete turístico con soporte en la realidad virtual a los clientes potenciales (turistas y/o visitantes que demandan este tipo de servicio, para quienes el espacio virtual) que, a su vez, se corresponderá con un diseño atractivo y como fuente de información sobre los diferentes destinos existentes en el país, siendo estos turistas el segmento clave al que va a ser dirigido el producto en sí. Además, las fuentes de ingresos de VR TOURS PERÚ, estarán dadas por las suscripciones de los usuarios para obtener los paquetes turísticos diseñados a partir de la realidad virtual, ofreciéndose así diferentes niveles de membresías con los que cada turista podrá disfrutar de una experiencia diferente de acuerdo con el tipo de membresía adquirida. En cambio, para operar la plataforma se requieren varios recursos establecidos de acuerdo con la funcionalidad demandada; El flujo para la selección del servicio, inicialmente, está en la elección del día y disponibilidad. La aplicación permite elegir día y hora de visita para la interacción en tiempo real con el guía de turismo, desde la comodidad de su hogar Siendo así, que el servicio turístico VR TOURS PERÚ, una plataforma de realidad virtual que trabaja juntamente con la fotogrametría y la digitalización. Esta plataforma virtual permitirá a los usuarios, realizar de tours virtuales, adaptados a los gustos, tiempos y necesidades de los clientes, organizar de eventos creados para los amantes de viajar, recomendar a expertos para el uso de la plataforma y para el agendamiento de viajes físicos después de la pandemia y establecer un catálogo de productos o servicios ofrecidos antes, durante y después de realizar un tour virtual. La estructura de capital, es la mezcla específica de deuda a largo plazo y de capital que la empresa utiliza para financiar sus operaciones. Los miembros o socios aportarán de capital propio S/ 158,613.05 y de capital prestado la diferencia de S/ 158,613.05 valores que conforman el aporte inicial de la inversión. Se seleccionó esta estructura de capital, ya que al ser una empresa que iniciará sus actividades se recomienda que el valor de la deuda a largo plazo se menor o igual al capital propio. En base al análisis financiero, se tiene una utilidad para el primer año de S/ 42,878.56; mediante la aplicación de indicadores para el primer año se tiene un margen operacional de 17.60%; una rentabilidad en ventas de 8.58%; un Retorno sobre los Activos de 19.05% y una Rentabilidad Financiera de 27.03%. Finalmente, una vez calculado el valor actual neto, se obtuvo un valor de S/ 409,297.04; determinando, así la factibilidad del proyecto por obtener un resultado positivo. Mientras que la Tasa Interna de Retorno representa una rentabilidad del 51% al ejecutar la inversión, es decir, que la ejecución de la información genera beneficios a futuro. Many companies in the tourism sector today have implemented the use of virtual reality as a mean to overcome the economic crisis generated by the pandemic; through digitalisation they have allowed them to reach more places and stay in the market. The virtual tours on this platform have the plus of being able to be synchronous and have a guide for each session. The virtual trip can be personalised, with greater complexity in its execution since schedules must be defined, with the added bonus of being able to be more personalised. Thus, VR TOURS PERU, aims to provide a tour package with virtual reality support to potential customers (tourists and / or visitors who demand this type of service, for whom the virtual space is created) which, in turn, it will correspond to an attractive design and as a source of information on the different destinations in the country, these tourists being the key segment to which the product itself will be directed. In addition, the sources of income of VR TOURS PERU will be given by the subscriptions users to obtain the tourist packages designed from virtual reality, thus offering different levels of memberships with which each tourist can enjoy a different experience according to the type of membership acquired. On the other hand, to operate the platform, several resources are required, established according to the functionality demanded; the flow for the selection of the service, initially, is in the choice of the day and availability. The application allows you to choose the day and time of your visit for real-time interaction with the tour guide, from the comfort of your home. Therefore the tourist service VR TOURS PERU, a virtual reality platform that works together with photogrammetry and digitalisation. This virtual platform will allow users to carry out virtual tours, adapted to the tastes, times and needs of clients, organise events created for travel lovers, recommend guide experts for the use of the platform and for travel scheduling physically after the pandemic and establish a catalog of products or services offered before, during and after taking a virtual tour. The capital structure is the specific mix of long-term debt and capital that the company uses to finance its operations. The members or partners will contribute S/ 158,613.05 of their own capital and of borrowed capital the difference of S/ 158,613.05 values that make up the initial investment contribution. This capital structure was selected, since being a company that will start its activities it is recommended that the value of the long-term debt be less than or equal to the equity capital. Based on the financial analysis, there is a profit for the first year of S/ S/ 42,878.56; Likewise, through the application of indicators for the first year, there is an operating margin of 17.60%; a profitability on sales of 8.58%; an Return of Assets of 19.05% and an Return of Equity of 27.03%. Finally, once the net present value was calculated, a value of S/ 409,297.04 was obtained; thus determining the feasibility of the project to obtain a positive result. While the Internal Rate of Return represents a return of 51% when executing the investment, that is, the execution of the information generates future benefits.

Published
2021

17. Muscle Thickness and Echogenicity Measured by Ultrasound Could Detect Local Sarcopenia and Malnutrition in Older Patients Hospitalized for Hip Fracture

Author

Sanz-Paris, Alejandro, primary, González-Fernandez, Mikel, additional, Hueso-Del Río, Luis Enrique, additional, Ferrer-Lahuerta, Eduardo, additional, Monge-Vazquez, Alejandra, additional, Losfablos-Callau, Francisco, additional, Sanclemente-Hernández, Teresa, additional, Sanz-Arque, Alejandro, additional, and Arbones-Mainar, Jose Miguel, additional

Published
2021
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19. De la academia al espacio público: Comunicar ciencia en México

Author

JIMÉNEZ, PATRICIA AGUILERA, BARAHONA, CHRISTOPHER ESTRADA, PLACENCIA, JAQUELINE GARZA, ARRIBAS, LUISA FERNANDA GONZÁLEZ, SANGUINO, JOAQUÍN M. GUTIÉRREZ, LIMA, SUSANA HERRERA, VÁZQUEZ, ALEJANDRA JARAMILLO, GONZÁLEZ, MARÍA TERESA JIMÉNEZ, MARTÍNEZ, CARLOS ENRIQUE OROZCO, ANDERSON, WILLIAM C. QUINN, LOBATÓN, AMALIA VIESCA, JIMÉNEZ, PATRICIA AGUILERA, BARAHONA, CHRISTOPHER ESTRADA, PLACENCIA, JAQUELINE GARZA, ARRIBAS, LUISA FERNANDA GONZÁLEZ, SANGUINO, JOAQUÍN M. GUTIÉRREZ, LIMA, SUSANA HERRERA, VÁZQUEZ, ALEJANDRA JARAMILLO, GONZÁLEZ, MARÍA TERESA JIMÉNEZ, MARTÍNEZ, CARLOS ENRIQUE OROZCO, ANDERSON, WILLIAM C. QUINN, and LOBATÓN, AMALIA VIESCA

Published
2016

22. Assessing Building Habitability after an Earthquake Using Building Typology and Damage Grade. Application in Lorca, Spain

Author

Martinez Cuevas, Sandra, Morillo Balsera, M Del Carmen, Benito Oterino, Maria Belen, Torres Fernandez, Yolanda, Gaspar Escribano, Jorge Miguel, Staller Vazquez, Alejandra, Garcia Aranda, Cesar, Martinez Cuevas, Sandra, Morillo Balsera, M Del Carmen, Benito Oterino, Maria Belen, Torres Fernandez, Yolanda, Gaspar Escribano, Jorge Miguel, Staller Vazquez, Alejandra, and Garcia Aranda, Cesar

Abstract

The present study proposes a statistical methodology to rate the habitability of different types of buildings after an earthquake. The first step was to rank variables that affect the vulnerability of a building and formulate a statistical study with a discrimination index that makes it possible to identify buildings as habitable or non-habitable. This ranking applied the criteria established in various international guidelines that are used to distinguish between habitable (undamaged/no structural damage) and non-habitable buildings (structural damage). The proposed methodology was applied to a database with information about buildings and damage grade experienced following the 2011 earthquake in Lorca. The approach presented could be extended to other regions where neccessary data are available.

Published
2020

25. Seismic hazard scenarios through different modeling of the Carboneras fault and its impact on the expected ground motion in the city of Almeria

Author

Benito Oterino, Maria Belen, Rivas Medina, Alicia, Gaspar Escribano, Jorge Miguel, Staller Vazquez, Alejandra, and Martinez Cuevas, Sandra

Subjects
Geología
Abstract

The Carboneras Fault, located in the Southeast Iberian Peninsula, is one of those with the highest slip rate (a), among the active faults in Spain, and is also one of the longest (L), which also makes it one of the highest potential seismic, in terms of the scalar seismic moment that could be released (Mo). According to QAFI v3 (IGME, 2015), a = 1.1 mm / year and L = 110.5 km, which would make possible an earthquake of magnitude Mw = 7.4, (using the of W & C'94 empirical relationship) with a recurrence interval of TR = 1150 years . The fault is strike slip and pleosysmic studies in it point to minimum of 6 events since the Mid Pleistocene observed in trenches along La Serrata (Moreno, 2010, Moreno et al., 2008) and an elapsed time for Mw 7.4 of 1178 years. On the other hand, the last major event reported historically in the fault is the one that occurred in 1522, with I (EMS) = IX and M = 6.5, which allows estimating an elapsed time of about 500 years for that magnitude. With the available data, hazard estimates have been developed from different fault modeling: 1) TC characteristic earthquake, 2) Brownian model of temporal dependence, 3) Renewal model and 4) Poisson model. The sensitivity of the results to the different source modeling is analyzed, and these are compared in turn with the PGA values of the latest seismic hazard map of Spain (UPM-IGN, 2013). Finally, we analize the impact of the results in the city of Almeria, which is one of the most vulnerable in southern Spain, which makes the impact spread to the seismic risk scenarios that can be expected due to future earthquakes.

Published
2019

26. Cuantificación de miRNAs en suero de mujeres con cáncer de mama y su relación con características clínico-patológicas

Author

LOPEZ VAZQUEZ, ALEJANDRA, 711573, and Astiazarán García, Humberto Francisco

Subjects
BIOLOGÍA MOLECULAR, RG493 .L66, Mamas, Cáncer
Abstract

Tesis de maestría en ciencias de la salud El cáncer de mama es un problema de salud que presenta alta incidencia y mortalidad. Limitaciones en los métodos de detección y complejidad de la enfermedad hacen necesario el desarrollo de nuevas herramientas diagnóstico. Diversos estudios demuestran el potencial de miRNAs, como biomarcador para cáncer de mama, como método diagnóstico menos invasivo, más rápido y que proporciona información sobre la enfermedad. La cuantificación sérica de miRNAs en pacientes con cáncer de mama surge como herramienta potencial en el diagnóstico de la enfermedad. En el presente estudio se cuantificaron, mediante PCR en tiempo real, un panel de miRNAs (miR-181a, miR-145, miR-155, y miR-205) seleccionado de la literatura, en suero de mujeres con cáncer de mama y mujeres sanas, y se exploró la relación entre su expresión con características clínicas y patológicas. El miR-205 presentó diferencias entre pacientes con cáncer de mama y sanas (P=0.0009), con baja-expresión en pacientes con la enfermedad. Se observaron diferencias en la expresión de miR-145 (P=0.002), miR-155 (P=0.004) y miR-205 (P= 0.04) respecto al grupo de edad. El análisis de medianas de los niveles de expresión (fold change) de miRNAs con relación a las características clínico-patológicas indicó relación entre miR-181a y miR-155 y presencia de invasión linfovascular y ganglios linfáticos involucrados; relación entre miR-181a y estadio clínico, así como miR-181a y miR-145 con el subtipo Luminal A. Los resultados sugieren que el análisis en suero del panel de miRNAs posee potencial para su uso como biomarcador en cáncer de mama, sin embargo, se recomienda aumentar el número de muestras para el análisis de la relación entre expresión y las características clínico-patológicas. Universidad de Sonora. División de Ciencias Biológicas y de la Salud. Programa de Maestría en Ciencias de la Salud. 2019

Published
2019

27. Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats

Author

Vazquez, Alejandra, primary, Sanchez-Rodriguez, Estefania, additional, Vargas, Félix, additional, Montoro-Molina, Sebastián, additional, Romero, Miguel, additional, Espejo-Calvo, Juan Antonio, additional, Vilchez, Pedro, additional, Jaramillo, Sara, additional, Olmo-García, Lucía, additional, Carrasco-Pancorbo, Alegría, additional, de la Torre, Rafael, additional, Fito, Montserrat, additional, Covas, María-Isabel, additional, Martínez de Victoria, Emilio, additional, and Mesa, Maria Dolores, additional

Published
2019
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29. The new methods for rapid exposure and seismic vulnerability assessment. How do they adapt to different scenarios?

Author

Torres Fernandez, Yolanda, Arranz Justel, Jose Juan, Martinez Cuevas, Sandra, Gaspar Escribano, Jorge Miguel, Benito Oterino, Maria Belen, Staller Vazquez, Alejandra, Gómez Doménech, Igor, Torres Fernandez, Yolanda, Arranz Justel, Jose Juan, Martinez Cuevas, Sandra, Gaspar Escribano, Jorge Miguel, Benito Oterino, Maria Belen, Staller Vazquez, Alejandra, and Gómez Doménech, Igor

Abstract

We present a procedure for exposure and vulnerability evaluation that integrates LiDAR, orthophotos, and other ancillary datasets. It comprises three phases: (1) city stratification into homogeneous regions; (2) exposure database compilation; and (3) vulnerability allocation using predictive modelling. We have conducted two applications in Lorca (Spain) and Port-au-Price (Haiti) and here we compare them. Each phase of the method is subject to variations due mainly to data availability; however, it does not affect the final accuracy that remains high in both scenarios (over 80%). It is a flexible procedure that is able to adapt to the particular features of two different cities.

Published
2019

30. De la academia al espacio público: Comunicar ciencia en México

Author

Herrera Lima, Susana, Orozco Martínez, Carlos Enrique, Aguilera Jiménez, Patricia, Estrada Barahona, Christopher Oliver Marsuskhievick, Garza Placencia, Jaqueline, González Arribas, Luisa Fernanda, Gutiérrez Sanguino, Joaquín Mateo, Jaramillo Vázquez, Alejandra, Jiménez González, María Teresa, Quinn Anderson, William Conway, Viesca Lobatón, Amalia, Herrera Lima, Susana, Orozco Martínez, Carlos Enrique, Aguilera Jiménez, Patricia, Estrada Barahona, Christopher Oliver Marsuskhievick, Garza Placencia, Jaqueline, González Arribas, Luisa Fernanda, Gutiérrez Sanguino, Joaquín Mateo, Jaramillo Vázquez, Alejandra, Jiménez González, María Teresa, Quinn Anderson, William Conway, and Viesca Lobatón, Amalia

Subjects
Communication in science--Mexico
Abstract

Esta obra da la oportunidad de conocer aproximaciones a la comunicación de la ciencia. El interés común de los autores es sumar perspectivas para una mejor comprensión de los aspectos teóricos–prácticos en la divulgación del conocimiento científico–tecnológico en nuestra sociedad. Este libro, fruto de la convicción de académicos, investigadores y estudiosos de la comunicación, está estructurado en tres partes: la primera, con ensayos sobre la profesionalización de la comunicación pública de la ciencia; la segunda, con investigaciones sobre la comunicación, el pensamiento crítico y la comunicación pública, y la tercera, con experiencias y modelos sobre espacios para comunicar la ciencia.

Published
2016

31. Estilos parentales y prácticas de alimentación y su relación en casos de niños con desnutrición

Author

GARCIA VAZQUEZ, ALEJANDRA GUADALUPE, 550504, and MONTIEL CARBAJAL, MARIA MARTHA

Subjects
Desnutrición infantil, RA645.N87 .G37, HÁBITOS ALIMENTARIOS
Abstract

Tesis de maestría en ciencias de la salud Los determinantes de la desnutrición infantil actúan a nivel social, comunitario, familiar e individual. En el contexto familiar, las prácticas de alimentación utilizadas por los padres y los estilos parentales son una parte importante y compleja en la interacción diaria que afecta el consumo de nutrientes del niño; por lo que, es necesario identificar aquellas prácticas de alimentación y estilos parentales que se utilizan, debido a que juegan un papel crítico en el desarrollo del gusto y preferencias de los niños, hábitos alimenticios y eventualmente en el peso. El objetivo de la presente investigación fue determinar las características de los estilos parentales y las prácticas de alimentación que utilizan las madres de niños con desnutrición y contrastar con las prácticas de alimentación y estilos parentales de madres de niños con peso normal. Para esto se condujo un estudio de tipo no experimental, transeccional con alcance descriptivo-comparativo con una muestra no probabilística por conveniencia de 56 participantes, que asistían a diversos Centros de Salud de Hermosillo, Sonora, divididas en dos grupos. Se aplicó el Cuestionario de Dimensiones y Estilos Parentales (PSDQ) y el Cuestionario Integral de Prácticas Alimenticias (CFPQ). Se realizó la medición de peso y talla para estimar su adecuación según los puntos de corte de la OMS (2006). Los resultados obtenidos no mostraron diferencias estadísticamente significativas entre los estilos parentales y prácticas de alimentación en ambos grupos, pero si se encontraron diferencias estadísticamente significativas entre los estilos y prácticas según las variables estatus de pareja, escolaridad y condiciones de bienestar. Universidad de Sonora. División de Ciencias Biólogicas y de la Salud. Programa de Maestría en Ciencias de la Salud 2015.

Published
2015

40. Plan de negocios para la creación de una plataforma para el servicio turístico

Author

Vargas Vazquez, Alejandra, Alarcon Alfaro, Juan Carlos, Olacua Moreno, Marco Antonio, Suárez Mendoza, Andrés Gustavo, Pardo D'Ornellas, Enrique Jose, Vargas Vazquez, Alejandra, Alarcon Alfaro, Juan Carlos, Olacua Moreno, Marco Antonio, Suárez Mendoza, Andrés Gustavo, and Pardo D'Ornellas, Enrique Jose

Abstract

Muchas empresas del sector turístico en la actualidad han implementado el uso de realidad virtual como medio para superar la crisis económico generada por la pandemia; mediante la digitalización se han permitido llegar a más lugares y mantenerse en el mercado. Los recorridos virtuales en esta plataforma tienen el plus de poder ser sincrónico y contar con un guía para cada sesión. El viaje virtual se puede personalizar, con una mayor complejidad en su ejecución, ya que se deben definir horarios, con un el plus de poder ser más personalizado. Es así que, VR TOURS PERÚ, tiene como objetivo brindar un paquete turístico con soporte en la realidad virtual a los clientes potenciales (turistas y/o visitantes que demandan este tipo de servicio, para quienes el espacio virtual) que, a su vez, se corresponderá con un diseño atractivo y como fuente de información sobre los diferentes destinos existentes en el país, siendo estos turistas el segmento clave al que va a ser dirigido el producto en sí. Además, las fuentes de ingresos de VR TOURS PERÚ, estarán dadas por las suscripciones de los usuarios para obtener los paquetes turísticos diseñados a partir de la realidad virtual, ofreciéndose así diferentes niveles de membresías con los que cada turista podrá disfrutar de una experiencia diferente de acuerdo con el tipo de membresía adquirida. En cambio, para operar la plataforma se requieren varios recursos establecidos de acuerdo con la funcionalidad demandada; El flujo para la selección del servicio, inicialmente, está en la elección del día y disponibilidad. La aplicación permite elegir día y hora de visita para la interacción en tiempo real con el guía de turismo, desde la comodidad de su hogar Siendo así, que el servicio turístico VR TOURS PERÚ, una plataforma de realidad virtual que trabaja juntamente con la fotogrametría y la digitalización. Esta plataforma virtual permitirá a los usuarios, realizar de tours virtuales, adaptados a los gustos, tiempos y necesidades de los cl, Many companies in the tourism sector today have implemented the use of virtual reality as a mean to overcome the economic crisis generated by the pandemic; through digitalisation they have allowed them to reach more places and stay in the market. The virtual tours on this platform have the plus of being able to be synchronous and have a guide for each session. The virtual trip can be personalised, with greater complexity in its execution since schedules must be defined, with the added bonus of being able to be more personalised. Thus, VR TOURS PERU, aims to provide a tour package with virtual reality support to potential customers (tourists and / or visitors who demand this type of service, for whom the virtual space is created) which, in turn, it will correspond to an attractive design and as a source of information on the different destinations in the country, these tourists being the key segment to which the product itself will be directed. In addition, the sources of income of VR TOURS PERU will be given by the subscriptions users to obtain the tourist packages designed from virtual reality, thus offering different levels of memberships with which each tourist can enjoy a different experience according to the type of membership acquired. On the other hand, to operate the platform, several resources are required, established according to the functionality demanded; the flow for the selection of the service, initially, is in the choice of the day and availability. The application allows you to choose the day and time of your visit for real-time interaction with the tour guide, from the comfort of your home. Therefore the tourist service VR TOURS PERU, a virtual reality platform that works together with photogrammetry and digitalisation. This virtual platform will allow users to carry out virtual tours, adapted to the tastes, times and needs of clients, organise events created for travel lovers, recommend guide experts for the use of the platform and for travel sch

41. Plan de negocios para la creación de una plataforma para el servicio turístico

Author

Vargas Vazquez, Alejandra, Alarcon Alfaro, Juan Carlos, Olacua Moreno, Marco Antonio, Suárez Mendoza, Andrés Gustavo, Pardo D'Ornellas, Enrique Jose, Vargas Vazquez, Alejandra, Alarcon Alfaro, Juan Carlos, Olacua Moreno, Marco Antonio, Suárez Mendoza, Andrés Gustavo, and Pardo D'Ornellas, Enrique Jose

Abstract

Muchas empresas del sector turístico en la actualidad han implementado el uso de realidad virtual como medio para superar la crisis económico generada por la pandemia; mediante la digitalización se han permitido llegar a más lugares y mantenerse en el mercado. Los recorridos virtuales en esta plataforma tienen el plus de poder ser sincrónico y contar con un guía para cada sesión. El viaje virtual se puede personalizar, con una mayor complejidad en su ejecución, ya que se deben definir horarios, con un el plus de poder ser más personalizado. Es así que, VR TOURS PERÚ, tiene como objetivo brindar un paquete turístico con soporte en la realidad virtual a los clientes potenciales (turistas y/o visitantes que demandan este tipo de servicio, para quienes el espacio virtual) que, a su vez, se corresponderá con un diseño atractivo y como fuente de información sobre los diferentes destinos existentes en el país, siendo estos turistas el segmento clave al que va a ser dirigido el producto en sí. Además, las fuentes de ingresos de VR TOURS PERÚ, estarán dadas por las suscripciones de los usuarios para obtener los paquetes turísticos diseñados a partir de la realidad virtual, ofreciéndose así diferentes niveles de membresías con los que cada turista podrá disfrutar de una experiencia diferente de acuerdo con el tipo de membresía adquirida. En cambio, para operar la plataforma se requieren varios recursos establecidos de acuerdo con la funcionalidad demandada; El flujo para la selección del servicio, inicialmente, está en la elección del día y disponibilidad. La aplicación permite elegir día y hora de visita para la interacción en tiempo real con el guía de turismo, desde la comodidad de su hogar Siendo así, que el servicio turístico VR TOURS PERÚ, una plataforma de realidad virtual que trabaja juntamente con la fotogrametría y la digitalización. Esta plataforma virtual permitirá a los usuarios, realizar de tours virtuales, adaptados a los gustos, tiempos y necesidades de los cl, Many companies in the tourism sector today have implemented the use of virtual reality as a mean to overcome the economic crisis generated by the pandemic; through digitalisation they have allowed them to reach more places and stay in the market. The virtual tours on this platform have the plus of being able to be synchronous and have a guide for each session. The virtual trip can be personalised, with greater complexity in its execution since schedules must be defined, with the added bonus of being able to be more personalised. Thus, VR TOURS PERU, aims to provide a tour package with virtual reality support to potential customers (tourists and / or visitors who demand this type of service, for whom the virtual space is created) which, in turn, it will correspond to an attractive design and as a source of information on the different destinations in the country, these tourists being the key segment to which the product itself will be directed. In addition, the sources of income of VR TOURS PERU will be given by the subscriptions users to obtain the tourist packages designed from virtual reality, thus offering different levels of memberships with which each tourist can enjoy a different experience according to the type of membership acquired. On the other hand, to operate the platform, several resources are required, established according to the functionality demanded; the flow for the selection of the service, initially, is in the choice of the day and availability. The application allows you to choose the day and time of your visit for real-time interaction with the tour guide, from the comfort of your home. Therefore the tourist service VR TOURS PERU, a virtual reality platform that works together with photogrammetry and digitalisation. This virtual platform will allow users to carry out virtual tours, adapted to the tastes, times and needs of clients, organise events created for travel lovers, recommend guide experts for the use of the platform and for travel sch

42. Plan de negocios para la creación de una plataforma para el servicio turístico

Author

Vargas Vazquez, Alejandra, Alarcon Alfaro, Juan Carlos, Olacua Moreno, Marco Antonio, Suárez Mendoza, Andrés Gustavo, Pardo D'Ornellas, Enrique Jose, Vargas Vazquez, Alejandra, Alarcon Alfaro, Juan Carlos, Olacua Moreno, Marco Antonio, Suárez Mendoza, Andrés Gustavo, and Pardo D'Ornellas, Enrique Jose

Abstract

Muchas empresas del sector turístico en la actualidad han implementado el uso de realidad virtual como medio para superar la crisis económico generada por la pandemia; mediante la digitalización se han permitido llegar a más lugares y mantenerse en el mercado. Los recorridos virtuales en esta plataforma tienen el plus de poder ser sincrónico y contar con un guía para cada sesión. El viaje virtual se puede personalizar, con una mayor complejidad en su ejecución, ya que se deben definir horarios, con un el plus de poder ser más personalizado. Es así que, VR TOURS PERÚ, tiene como objetivo brindar un paquete turístico con soporte en la realidad virtual a los clientes potenciales (turistas y/o visitantes que demandan este tipo de servicio, para quienes el espacio virtual) que, a su vez, se corresponderá con un diseño atractivo y como fuente de información sobre los diferentes destinos existentes en el país, siendo estos turistas el segmento clave al que va a ser dirigido el producto en sí. Además, las fuentes de ingresos de VR TOURS PERÚ, estarán dadas por las suscripciones de los usuarios para obtener los paquetes turísticos diseñados a partir de la realidad virtual, ofreciéndose así diferentes niveles de membresías con los que cada turista podrá disfrutar de una experiencia diferente de acuerdo con el tipo de membresía adquirida. En cambio, para operar la plataforma se requieren varios recursos establecidos de acuerdo con la funcionalidad demandada; El flujo para la selección del servicio, inicialmente, está en la elección del día y disponibilidad. La aplicación permite elegir día y hora de visita para la interacción en tiempo real con el guía de turismo, desde la comodidad de su hogar Siendo así, que el servicio turístico VR TOURS PERÚ, una plataforma de realidad virtual que trabaja juntamente con la fotogrametría y la digitalización. Esta plataforma virtual permitirá a los usuarios, realizar de tours virtuales, adaptados a los gustos, tiempos y necesidades de los cl, Many companies in the tourism sector today have implemented the use of virtual reality as a mean to overcome the economic crisis generated by the pandemic; through digitalisation they have allowed them to reach more places and stay in the market. The virtual tours on this platform have the plus of being able to be synchronous and have a guide for each session. The virtual trip can be personalised, with greater complexity in its execution since schedules must be defined, with the added bonus of being able to be more personalised. Thus, VR TOURS PERU, aims to provide a tour package with virtual reality support to potential customers (tourists and / or visitors who demand this type of service, for whom the virtual space is created) which, in turn, it will correspond to an attractive design and as a source of information on the different destinations in the country, these tourists being the key segment to which the product itself will be directed. In addition, the sources of income of VR TOURS PERU will be given by the subscriptions users to obtain the tourist packages designed from virtual reality, thus offering different levels of memberships with which each tourist can enjoy a different experience according to the type of membership acquired. On the other hand, to operate the platform, several resources are required, established according to the functionality demanded; the flow for the selection of the service, initially, is in the choice of the day and availability. The application allows you to choose the day and time of your visit for real-time interaction with the tour guide, from the comfort of your home. Therefore the tourist service VR TOURS PERU, a virtual reality platform that works together with photogrammetry and digitalisation. This virtual platform will allow users to carry out virtual tours, adapted to the tastes, times and needs of clients, organise events created for travel lovers, recommend guide experts for the use of the platform and for travel sch

45. Socioeconomic, Clinical, and Molecular Features of Breast Cancer Influence Overall Survival of Latin American Women.

Author

de Almeida LM, Cortés S, Vilensky M, Valenzuela O, Cortes-Sanabria L, de Souza M, Barbeito RA, Abdelhay E, Artagaveytia N, Daneri-Navarro A, Llera AS, Müller B, Podhajcer OL, Velazquez C, Alcoba E, Alonso I, Bravo AI, Camejo N, Carraro DM, Castro M, Cataldi S, Cayota A, Cerda M, Colombo A, Crocamo S, Del Toro-Arreola A, Delgadillo-Cristerna R, Delgado L, Breitenbach MD, Fernández E, Fernández J, Fernández W, Franco-Topete RA, Gaete F, Gómez J, Gonzalez-Ramirez LP, Guerrero M, Gutierrez-Rubio SA, Jalfin B, Lopez-Vazquez A, Loria D, Míguez S, Moran-Mendoza AJ, Morgan-Villela G, Mussetti C, Nagai MA, Oceguera-Villanueva A, Reis RM, Retamales J, Rodriguez R, Rosales C, Salas-Gonzalez E, Segovia L, Sendoya JM, Silva-Garcia AA, Viña S, Zagame L, Jones B, and Szklo M

Abstract

Molecular profile of breast cancer in Latin-American women was studied in five countries: Argentina, Brazil, Chile, Mexico, and Uruguay. Data about socioeconomic characteristics, risk factors, prognostic factors, and molecular subtypes were described, and the 60-month overall cumulative survival probabilities (OS) were estimated. From 2011 to 2013, 1,300 eligible Latin-American women 18 years or older, with a diagnosis of breast cancer in clinical stage II or III, and performance status ≦̸1 were invited to participate in a prospective cohort study. Face-to-face interviews were conducted, and clinical and outcome data, including death, were extracted from medical records. Unadjusted associations were evaluated by Chi-squared and Fisher's exact tests and the OS by Kaplan-Meier method. Log-rank test was used to determine differences between cumulative probability curves. Multivariable adjustment was carried out by entering potential confounders in the Cox regression model. The OS at 60 months was 83.9%. Multivariable-adjusted death hazard differences were found for women living in Argentina (2.27), Chile (1.95), and Uruguay (2.42) compared with Mexican women, for older (≥60 years) (1.84) compared with younger (≤40 years) women, for basal-like subtype (5.8), luminal B (2.43), and HER2-enriched (2.52) compared with luminal A subtype, and for tumor clinical stages IIB (1.91), IIIA (3.54), and IIIB (3.94) compared with stage IIA women. OS was associated with country of residence, PAM50 intrinsic subtype, age, and tumor stage at diagnosis. While the latter is known to be influenced by access to care, including cancer screening, timely diagnosis and treatment, including access to more effective treatment protocols, it may also influence epigenetic changes that, potentially, impact molecular subtypes. Data derived from heretofore understudied populations with unique geographic ancestry and sociocultural experiences are critical to furthering our understanding of this complexity., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 de Almeida, Cortés, Vilensky, Valenzuela, Cortes-Sanabria, de Souza, Barbeito, Abdelhay, Artagaveytia, Daneri-Navarro, Llera, Müller, Podhajcer, Velazquez, Alcoba, Alonso, Bravo, Camejo, Carraro, Castro, Cataldi, Cayota, Cerda, Colombo, Crocamo, Del Toro-Arreola, Delgadillo-Cristerna, Delgado, Breitenbach, Fernández, Fernández, Fernández, Franco-Topete, Gaete, Gómez, Gonzalez-Ramirez, Guerrero, Gutierrez-Rubio, Jalfin, Lopez-Vazquez, Loria, Míguez, Moran-Mendoza, Morgan-Villela, Mussetti, Nagai, Oceguera-Villanueva, Reis, Retamales, Rodriguez, Rosales, Salas-Gonzalez, Segovia, Sendoya, Silva-Garcia, Viña, Zagame, Jones, Szklo and United States-Latin American Cancer Research Network (US-LACRN).)

Published
2022
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