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217 results on '"Vazir, Ali"'

1. Race- and Ethnicity-Related Differences in Heart Failure With Preserved Ejection Fraction Using Natural Language Processing

Author

Brown, Sam, Biswas, Dhruva, Wu, Jack, Ryan, Matthew, Bernstein, Brett S., Fairhurst, Natalie, Kaye, George, Baral, Ranu, Cannata, Antonio, Searle, Tom, Melikian, Narbeh, Sado, Daniel, Lüscher, Thomas F., Teo, James, Dobson, Richard, Bromage, Daniel I., McDonagh, Theresa A., Vazir, Ali, Shah, Ajay M., and O’Gallagher, Kevin

Published
2024
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2. Assessment of left ventricular tissue mitochondrial bioenergetics in patients with stable coronary artery disease

Author

Jones, Richard E., Gruszczyk, Anja V., Schmidt, Christina, Hammersley, Daniel J., Mach, Lukas, Lee, Michael, Wong, Joyce, Yang, Ming, Hatipoglu, Suzan, Lota, Amrit S., Barnett, Sam N., Toscano-Rivalta, Rebecca, Owen, Ruth, Raja, Shahzad, De Robertis, Fabio, Smail, Hassiba, De-Souza, Anthony, Stock, Ulrich, Kellman, Peter, Griffin, Julian, Dumas, Marc-Emmanuel, Martin, Jack L., Saeb-Parsy, Kourosh, Vazir, Ali, Cleland, John G. F., Pennell, Dudley J., Bhudia, Sunil K., Halliday, Brian P., Noseda, Michela, Frezza, Christian, Murphy, Michael P., and Prasad, Sanjay K.

Published
2023
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3. Comprehensive Phenotypic Characterization of Late Gadolinium Enhancement Predicts Sudden Cardiac Death in Coronary Artery Disease

Author

Jones, Richard E., Zaidi, Hassan A., Hammersley, Daniel J., Hatipoglu, Suzan, Owen, Ruth, Balaban, Gabriel, de Marvao, Antonio, Simard, François, Lota, Amrit S., Mahon, Ciara, Almogheer, Batool, Mach, Lukas, Musella, Francesca, Chen, Xiuyu, Gregson, John, Lazzari, Laura, Ravendren, Andrew, Leyva, Francisco, Zhao, Shihua, Vazir, Ali, Lamata, Pablo, Halliday, Brian P., Pennell, Dudley J., Bishop, Martin J., and Prasad, Sanjay K.

Published
2023
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6. 134 Race and ethnicity-related differences in the diagnosis of heart failure with preserved ejection fraction using natural language processing

Author

Brown, Sam, primary, Biswas, Dhruva, additional, Wu, Ho Chung, additional, Ryan, Matt, additional, Bernstein, Brett, additional, Fairhurst, Natalie, additional, Kaye, George, additional, Baral, Ranu, additional, Cannata, Antonio, additional, Searle, Thomas, additional, Melikian, Narbeh, additional, Sado, Daniel, additional, Lüscher, Thomas, additional, Teo, James, additional, Dobson, Richard, additional, Bromage, Daniel, additional, McDonagh, Theresa, additional, Vazir, Ali, additional, Shah, Ajay, additional, and O’Gallagher, Kevin, additional

Published
2024
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10. Assessing the association between genetic and phenotypic features of dilated cardiomyopathy and outcome in patients with coronary artery disease

Author

Jones, Richard E., primary, Hammersley, Daniel J., additional, Zheng, Sean, additional, McGurk, Kathryn A., additional, de. Marvao, Antonio, additional, Theotokis, Pantazis I., additional, Owen, Ruth, additional, Tayal, Upasana, additional, Rea, Gillian, additional, Hatipoglu, Suzan, additional, Buchan, Rachel J., additional, Mach, Lukas, additional, Curran, Lara, additional, Lota, Amrit S., additional, Simard, François, additional, Reddy, Rohin K., additional, Talukder, Suprateeka, additional, Yoon, Won Young, additional, Vazir, Ali, additional, Pennell, Dudley J., additional, O'Regan, Declan P., additional, Baksi, A. John, additional, Halliday, Brian P., additional, Ware, James S., additional, and Prasad, Sanjay K., additional

Published
2023
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11. Decongestion strategies in patients presenting with acutely decompensated heart failure: A worldwide survey among physicians

Author

Vazir, Ali, primary, Kapelios, Chris J., additional, Agaoglu, Elif, additional, Metra, Marco, additional, Lopatin, Yury, additional, Seferovic, Petar, additional, Mullens, Wilfred, additional, Filippatos, Gerasimos, additional, Rosano, Giuseppe, additional, Coats, Andrew J.S., additional, and Chioncel, Ovidiu, additional

Published
2023
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18. Assessing the association between genetic and phenotypic features of dilated cardiomyopathy and outcome in patients with coronary artery disease.

Author

Jones, Richard E., Hammersley, Daniel J., Zheng, Sean, McGurk, Kathryn A., de Marvao, Antonio, Theotokis, Pantazis I., Owen, Ruth, Tayal, Upasana, Rea, Gillian, Hatipoglu, Suzan, Buchan, Rachel J., Mach, Lukas, Curran, Lara, Lota, Amrit S., Simard, François, Reddy, Rohin K., Talukder, Suprateeka, Yoon, Won Young, Vazir, Ali, and Pennell, Dudley J.

Subjects
CORONARY artery disease, DILATED cardiomyopathy, VENTRICULAR ejection fraction, PHENOTYPES, VENTRICULAR remodeling
Abstract

Aims: To examine the relevance of genetic and cardiovascular magnetic resonance (CMR) features of dilated cardiomyopathy (DCM) in individuals with coronary artery disease (CAD). Methods and results: This study includes two cohorts. First, individuals with CAD recruited into the UK Biobank (UKB) were evaluated. Second, patients with CAD referred to a tertiary centre for evaluation with late gadolinium enhancement (LGE)‐CMR were recruited (London cohort); patients underwent genetic sequencing as part of the research protocol and long‐term follow‐up. From 31 154 individuals with CAD recruited to UKB, rare pathogenic variants in DCM genes were associated with increased risk of death or major adverse cardiac events (hazard ratio 1.57, 95% confidence interval [CI] 1.22–2.01, p < 0.001). Of 1619 individuals with CAD included from the UKB CMR substudy, participants with a rare variant in a DCM‐associated gene had lower left ventricular ejection fraction (LVEF) compared to genotype negative individuals (mean 47 ± 10% vs. 57 ± 8%, p < 0.001). Of 453 patients in the London cohort, 63 (14%) had non‐infarct pattern LGE (NI‐LGE) on CMR. Patients with NI‐LGE had lower LVEF (mean 38 ± 18% vs. 48 ± 16%, p < 0.001) compared to patients without NI‐LGE, with no significant difference in the burden of rare protein altering variants in DCM‐associated genes between groups (9.5% vs. 6.7%, odds ratio 1.5, 95% CI 0.4–4.3, p = 0.4). NI‐LGE was not independently associated with adverse clinical outcomes. Conclusion: Rare pathogenic variants in DCM‐associated genes impact left ventricular remodelling and outcomes in stable CAD. NI‐LGE is associated with adverse remodelling but is not an independent predictor of outcome and had no rare genetic basis in our study. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Comprehensive Phenotypic Characterization of Late Gadolinium Enhancement Predicts Sudden Cardiac Death in Coronary Artery Disease

Author

Jones, Richard E, Zaidi, Hassan A, Hammersley, Daniel J, Hatipoglu, Suzan, Owen, Ruth, Balaban, Gabriel, de Marvao, Antonio, Simard, François, Lota, Amrit S, Mahon, Ciara, Almogheer, Batool, Mach, Lukas, Musella, Francesca, Chen, Xiuyu, Gregson, John, Lazzari, Laura, Ravendren, Andrew, Leyva, Francisco, Zhao, Shihua, Vazir, Ali, Lamata, Pablo, Halliday, Brian P, Pennell, Dudley J, Bishop, Martin J, Prasad, Sanjay K, Jones, Richard E, Zaidi, Hassan A, Hammersley, Daniel J, Hatipoglu, Suzan, Owen, Ruth, Balaban, Gabriel, de Marvao, Antonio, Simard, François, Lota, Amrit S, Mahon, Ciara, Almogheer, Batool, Mach, Lukas, Musella, Francesca, Chen, Xiuyu, Gregson, John, Lazzari, Laura, Ravendren, Andrew, Leyva, Francisco, Zhao, Shihua, Vazir, Ali, Lamata, Pablo, Halliday, Brian P, Pennell, Dudley J, Bishop, Martin J, and Prasad, Sanjay K

Abstract

BACKGROUND: Late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) offers the potential to noninvasively characterize the phenotypic substrate for sudden cardiac death (SCD). OBJECTIVES: The authors assessed the utility of infarct characterization by CMR, including scar microstructure analysis, to predict SCD in patients with coronary artery disease (CAD). METHODS: Patients with stable CAD were prospectively recruited into a CMR registry. LGE quantification of core infarction and the peri-infarct zone (PIZ) was performed alongside computational image analysis to extract morphologic and texture scar microstructure features. The primary outcome was SCD or aborted SCD. RESULTS: Of 437 patients (mean age: 64 years; mean left ventricular ejection fraction [LVEF]: 47%) followed for a median of 6.3 years, 49 patients (11.2%) experienced the primary outcome. On multivariable analysis, PIZ mass and core infarct mass were independently associated with the primary outcome (per gram: HR: 1.07 [95% CI: 1.02-1.12]; P = 0.002 and HR: 1.03 [95% CI: 1.01-1.05]; P = 0.01, respectively), and the addition of both parameters improved discrimination of the model (Harrell's C-statistic: 0.64-0.79). PIZ mass, however, did not provide incremental prognostic value over core infarct mass based on Harrell's C-statistic or risk reclassification analysis. Severely reduced LVEF did not predict the primary endpoint after adjustment for scar mass. On scar microstructure analysis, the number of LGE islands in addition to scar transmurality, radiality, interface area, and entropy were all associated with the primary outcome after adjustment for severely reduced LVEF and New York Heart Association functional class of >1. No scar microstructure feature remained associated with the primary endpoint when PIZ mass and core infarct mass were added to the regression models. CONCLUSIONS: Comprehensive LGE characterization independently predicted SCD risk beyond conventional predictors used in imp

Published
2023

22. Iatrogenic Tricuspid Regurgitation Associated With Pacemakers: A Case Compounded by Tricuspid Stenosis

Author

Duncan, Rory, Sharma, Rakesh, Vazir, Ali, Rosendahl, Ulrich, and Duncan, Alison

Subjects
Case Report
Abstract

A patient presented with severe tricuspid regurgitation 20 years after dual-chamber pacing. Transesophageal echocardiography suggested ventricular pacing wire adherence to the tricuspid valve (TV) and atrial wire prolapse across the tricuspid annulus. Surgical extraction of the pacing wires revealed TV commissural fusion and subvalvular thickening causing tricuspid stenosis, requiring TV replacement. (Level of Difficulty: Intermediate.)

Published
2023

30. Changes in clinical and imaging variables during withdrawal of heart failure therapy in recovered dilated cardiomyopathy

Author

Halliday, Brian P., primary, Owen, Ruth, additional, Gregson, John, additional, Vazir, Ali, additional, Wassall, Rebecca, additional, Khalique, Zohya, additional, Lota, Amrit S., additional, Tayal, Upasana, additional, Hammersley, Daniel J., additional, Jones, Richard E., additional, Pennell, Dudley J., additional, Cowie, Martin R., additional, Cleland, John G.F., additional, and Prasad, Sanjay K., additional

Published
2022
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32. Abstract 10211: Longitudinal Changes in Clinical and Imaging Variables During Withdrawal of Heart Failure Therapy in Patients with Recovered Dilated Cardiomyopathy: An Analysis from TRED-HF

Author

Halliday, Brian P, primary, Owen, Ruth, additional, Gregson, John, additional, Vazir, Ali, additional, Lota, Amrit S, additional, Khalique, Zohya, additional, Cowie, Martin R, additional, Pennell, Dudley, additional, Cleland, John, additional, and Prasad, Sanjay K, additional

Published
2021
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35. Multimodality imaging in transcatheter aortic valve implantation: comparison between cardiovascular magnetic resonance, cardiac computed tomography, transesophageal and transthoracic echocardiography

Author

Jabbour Andrew, Ismail Tevfik F, Vazir Ali, Roussin Isabelle, Gulati Ankur, Alpendurada Francisco, Zaman Sameer, Sotubo Oluwatosin, Zaman Saman S, Krishnamoorthy Ashwin, Davies Simon, Prasad Sanjay K, Price Susanna, Rubens Michael B, Moat Neil, and Mohiaddin Raad H

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2012
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36. Multimodality assessment of aortic stenosis severity in Transcatheter Aortic Valve Implantation (TAVI): comparison between cardiovascular magnetic resonance, transesophageal and transthoracic echocardiography

Author

Jabbour Andrew, Ismail Tevfik F, Vazir Ali, Roussin Isabelle, Gulati Ankur, Alpendurada Francisco, Zaman Sameer, Sotubo Oluwatosin, Zaman Saman S, Hewins Benjamin, Davies Simon, Prasad Sanjay K, Price Susanna, Rubens Michael B, Moat Neil, and Mohiaddin Raad H

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2012
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37. Relationship between heart rate and outcomes in patients in sinus rhythm or atrial fibrillation with heart failure and reduced ejection fraction

Author

Docherty, Kieran F., Shen, Li, Castagno, Davide, Petrie, Mark C., Abraham, William T., Böhm, Michael, Desai, Akshay S., Dickstein, Kenneth, Køber, Lars V., Packer, Milton, Rouleau, Jean L., Solomon, Scott D., Swedberg, Karl, Vazir, Ali, Zile, Michael R., Jhund, Pardeep S., McMurray, John J.V., Docherty, Kieran F., Shen, Li, Castagno, Davide, Petrie, Mark C., Abraham, William T., Böhm, Michael, Desai, Akshay S., Dickstein, Kenneth, Køber, Lars V., Packer, Milton, Rouleau, Jean L., Solomon, Scott D., Swedberg, Karl, Vazir, Ali, Zile, Michael R., Jhund, Pardeep S., and McMurray, John J.V.

Abstract

Aims: To investigate the relationship between heart rate and outcomes in heart failure and reduced ejection fraction (HFrEF) patients in sinus rhythm (SR) and atrial fibrillation (AF) adjusting for natriuretic peptide concentration, a powerful prognosticator. Methods and results: Of 13 562 patients from two large HFrEF trials, 10 113 (74.6%) were in SR and 3449 (25.4%) in AF. The primary endpoint was the composite of cardiovascular death or heart failure hospitalization. Heart rate was analysed as a categorical (tertiles, T1–3) and continuous variable (per 10 bpm), separately in patients in SR and AF. Outcomes were adjusted for prognostic variables, including N-terminal prohormone of B-type natriuretic peptide (NT-proBNP), and also examined using change from baseline heart rate to 1 year (≤ −10 bpm, ≥ +10 bpm, < ±10 bpm). SR patients with a higher heart rate had worse symptoms and quality of life, more often had diabetes and higher NT-proBNP concentrations. They had higher risk of the primary endpoint [T3 vs. T1 adjusted hazard ratio (HR) 1.50, 95% confidence interval (CI) 1.35–1.66; P < 0.001; per 10 bpm: 1.12, 95% CI 1.09–1.16; P < 0.001]. In SR, heart rate was associated with a relatively higher risk of pump failure than sudden death (adjusted HR per 10 bpm 1.17, 95% CI 1.09–1.26; P < 0.001 vs. 1.07, 95% CI 1.02–1.13; P = 0.011). Heart rate was not predictive of any outcome in AF. Conclusions: In HFrEF, an elevated heart rate was an independent predictor of adverse cardiovascular outcomes in patients in SR, even after adjustment for NT-proBNP. There was no relationship between heart rate and outcomes in AF. Clinical Trial Registration: ClinicalTrials.gov Identifiers NCT01035255 and NCT00853658.

Published
2020

47. Relationship between heart rate and outcomes in patients in sinus rhythm or atrial fibrillation with heart failure and reduced ejection fraction

Author

Docherty, Kieran F., primary, Shen, Li, additional, Castagno, Davide, additional, Petrie, Mark C., additional, Abraham, William T., additional, Böhm, Michael, additional, Desai, Akshay S., additional, Dickstein, Kenneth, additional, Køber, Lars V., additional, Packer, Milton, additional, Rouleau, Jean L., additional, Solomon, Scott D., additional, Swedberg, Karl, additional, Vazir, Ali, additional, Zile, Michael R., additional, Jhund, Pardeep S., additional, and McMurray, John J.V., additional

Published
2019
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