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3. Exonic knockout and knockin gene editing in hematopoietic stem and progenitor cells rescues RAG1 immunodeficiency

Author

Castiello, M, Brandas, C, Ferrari, S, Porcellini, S, Sacchetti, N, Canarutto, D, Draghici, E, Merelli, I, Barcella, M, Pelosi, G, Vavassori, V, Varesi, A, Jacob, A, Scala, S, Basso Ricci, L, Paulis, M, Strina, D, Di Verniere, M, Sergi Sergi, L, Serafini, M, Holland, S, Bergerson, J, De Ravin, S, Malech, H, Pala, F, Bosticardo, M, Brombin, C, Cugnata, F, Calzoni, E, Crooks, G, Notarangelo, L, Genovese, P, Naldini, L, Villa, A, Castiello, Maria Carmina, Brandas, Chiara, Ferrari, Samuele, Porcellini, Simona, Sacchetti, Nicolò, Canarutto, Daniele, Draghici, Elena, Merelli, Ivan, Barcella, Matteo, Pelosi, Gabriele, Vavassori, Valentina, Varesi, Angelica, Jacob, Aurelien, Scala, Serena, Basso Ricci, Luca, Paulis, Marianna, Strina, Dario, Di Verniere, Martina, Sergi Sergi, Lucia, Serafini, Marta, Holland, Steven M., Bergerson, Jenna R. E., De Ravin, Suk See, Malech, Harry L., Pala, Francesca, Bosticardo, Marita, Brombin, Chiara, Cugnata, Federica, Calzoni, Enrica, Crooks, Gay M., Notarangelo, Luigi D., Genovese, Pietro, Naldini, Luigi, Villa, Anna, Castiello, M, Brandas, C, Ferrari, S, Porcellini, S, Sacchetti, N, Canarutto, D, Draghici, E, Merelli, I, Barcella, M, Pelosi, G, Vavassori, V, Varesi, A, Jacob, A, Scala, S, Basso Ricci, L, Paulis, M, Strina, D, Di Verniere, M, Sergi Sergi, L, Serafini, M, Holland, S, Bergerson, J, De Ravin, S, Malech, H, Pala, F, Bosticardo, M, Brombin, C, Cugnata, F, Calzoni, E, Crooks, G, Notarangelo, L, Genovese, P, Naldini, L, Villa, A, Castiello, Maria Carmina, Brandas, Chiara, Ferrari, Samuele, Porcellini, Simona, Sacchetti, Nicolò, Canarutto, Daniele, Draghici, Elena, Merelli, Ivan, Barcella, Matteo, Pelosi, Gabriele, Vavassori, Valentina, Varesi, Angelica, Jacob, Aurelien, Scala, Serena, Basso Ricci, Luca, Paulis, Marianna, Strina, Dario, Di Verniere, Martina, Sergi Sergi, Lucia, Serafini, Marta, Holland, Steven M., Bergerson, Jenna R. E., De Ravin, Suk See, Malech, Harry L., Pala, Francesca, Bosticardo, Marita, Brombin, Chiara, Cugnata, Federica, Calzoni, Enrica, Crooks, Gay M., Notarangelo, Luigi D., Genovese, Pietro, Naldini, Luigi, and Villa, Anna

Abstract

Recombination activating genes (RAGs) are tightly regulated during lymphoid differentiation, and their mutations cause a spectrum of severe immunological disorders. Hematopoietic stem and progenitor cell (HSPC) transplantation is the treatment of choice but is limited by donor availability and toxicity. To overcome these issues, we developed gene editing strategies targeting a corrective sequence into the human RAG1 gene by homology-directed repair (HDR) and validated them by tailored two-dimensional, three-dimensional, and in vivo xenotransplant platforms to assess rescue of expression and function. Whereas integration into intron 1 of RAG1 achieved suboptimal correction, in-frame insertion into exon 2 drove physiologic human RAG1 expression and activity, allowing disruption of the dominant-negative effects of unrepaired hypomorphic alleles. Enhanced HDR-mediated gene editing enabled the correction of human RAG1 in HSPCs from patients with hypomorphic RAG1 mutations to overcome T and B cell differentiation blocks. Gene correction efficiency exceeded the minimal proportion of functional HSPCs required to rescue immunodeficiency in Rag1(-/- )mice, supporting the clinical translation of HSPC gene editing for the treatment of RAG1 deficiency.

Published
2024

4. USE DOSE OF SURFACE MAPS TO IDENTIFY BLADDER SUB-REGIONS ASSOCIATED WITH LATE TOXICITIES AFTER PROSTATE CANCER RADIOTHERAPY

Author

Gioscio, E., primary, Cicchetti, A., additional, Iacovacci, J., additional, Spampinato, S., additional, Avuzzi, B., additional, Chiorda, B. Noris, additional, Badenchini, F., additional, Waskiewicz, J.M., additional, Garibaldi, E., additional, Villa, E., additional, Magli, A., additional, Cante, D., additional, Girelli, G., additional, Gatti, M., additional, Farella, L., additional, Ferrari, P., additional, Piva, C., additional, Pavarini, M., additional, Valdagni, R., additional, Vavassori, V., additional, Munoz, F., additional, Fiorino, C., additional, Cozzarini, C., additional, and Rancati, T., additional

Published
2023
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5. ASSOCIATION OF PERSISTENT URINARY SYMPTOMS WITH QUALITY OF LIFE AFTER PROSTATE CANCER RADIOTHERAPY

Author

Spampinato, S., primary, Waskiewicz, J.M., additional, Avuzzi, B., additional, Garibaldi, E., additional, Faiella, A., additional, Villa, E., additional, Magli, A., additional, Cante, D., additional, Girelli, G., additional, Gatti, M., additional, Chiorda, B. Noris, additional, Rago, L., additional, Ferrari, P., additional, Piva, C., additional, Pavarini, M., additional, Rancati, T., additional, Valdagni, R., additional, Vavassori, V., additional, Munoz, F., additional, Sanguineti, G., additional, Di Muzio, N., additional, Kirchheiner, K., additional, Fiorino, C., additional, and Cozzarini, C., additional

Published
2023
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6. Almost one year of COVID-19 pandemic: how radiotherapy centers have counteracted its impact on cancer treatment in Lombardy, Italy. CODRAL/AIRO-L study

Author

Jereczek-Fossa, B, Palazzi, M, Tonoli, S, Zaffaroni, M, Marvaso, G, Ivaldi, G, Amadori, M, Antognoni, P, Arcangeli, S, Buffoli, A, Beltramo, G, Bignardi, M, Bracelli, S, De Stefani, A, Castiglioni, S, Catalano, G, Di Muzio, N, Cerrotta, A, Fariselli, L, Filippi, A, Gramaglia, A, Italia, C, Massaro, P, Magrini, S, Nava, S, Orlandi, E, Pasinetti, N, Sbicego, E, Scandolaro, L, Scorsetti, M, Barbonetti, C, Tortini, R, Valdagni, R, Vavassori, V, Pepa, M, Cazzaniga, L, Soatti, C, Jereczek-Fossa B. A., Palazzi M. F., Tonoli S., Zaffaroni M., Marvaso G., Ivaldi G. B., Amadori M., Antognoni P., Arcangeli S., Buffoli A., Beltramo G., Bignardi M., Bracelli S., De Stefani A., Castiglioni S., Catalano G., Di Muzio N., Cerrotta A., Fariselli L., Filippi A. R., Gramaglia A., Italia C., Massaro P., Magrini S. M., Nava S., Orlandi E., Pasinetti N., Sbicego E. L., Scandolaro L., Scorsetti M., Barbonetti C., Tortini R., Valdagni R., Vavassori V., Pepa M., Cazzaniga L. F., Soatti C. P., Jereczek-Fossa, B, Palazzi, M, Tonoli, S, Zaffaroni, M, Marvaso, G, Ivaldi, G, Amadori, M, Antognoni, P, Arcangeli, S, Buffoli, A, Beltramo, G, Bignardi, M, Bracelli, S, De Stefani, A, Castiglioni, S, Catalano, G, Di Muzio, N, Cerrotta, A, Fariselli, L, Filippi, A, Gramaglia, A, Italia, C, Massaro, P, Magrini, S, Nava, S, Orlandi, E, Pasinetti, N, Sbicego, E, Scandolaro, L, Scorsetti, M, Barbonetti, C, Tortini, R, Valdagni, R, Vavassori, V, Pepa, M, Cazzaniga, L, Soatti, C, Jereczek-Fossa B. A., Palazzi M. F., Tonoli S., Zaffaroni M., Marvaso G., Ivaldi G. B., Amadori M., Antognoni P., Arcangeli S., Buffoli A., Beltramo G., Bignardi M., Bracelli S., De Stefani A., Castiglioni S., Catalano G., Di Muzio N., Cerrotta A., Fariselli L., Filippi A. R., Gramaglia A., Italia C., Massaro P., Magrini S. M., Nava S., Orlandi E., Pasinetti N., Sbicego E. L., Scandolaro L., Scorsetti M., Barbonetti C., Tortini R., Valdagni R., Vavassori V., Pepa M., Cazzaniga L. F., and Soatti C. P.

Abstract

Lombardy has represented the Italian and European epicenter of the coronavirus disease 2019 (COVID-19) pandemic. Although most clinical efforts within hospitals were diverted towards the care of virally infected patients, therapies for patients with cancer, including radiotherapy (RT), have continued. During both the first and second pandemic waves, several national and regional organizations provided Italian and Lombardian RT departments with detailed guidelines aimed at ensuring safe treatments during the pandemic. The spread of infection among patients and personnel was limited by adopting strict measures, including triage procedures, interpersonal distance, and adequate implementation of personal protective equipment (PPE). Screening procedures addressed to both the healthcare workforce and patients, such as periodic nasopharyngeal swabs, have allowed the early identification of asymptomatic or pauci-symptomatic COVID-19 cases, thus reducing the spread of the infection. Prevention of infection was deemed of paramount importance to protect both patients and personnel and to ensure the availability of a minimum number of staff members to maintain clinical activity. The choice of treating COVID-19–positive patients has represented a matter of debate, and the risk of oncologic progression has been weighted against the risk of infection of personnel and other patients. Such risk was minimized by creating dedicated paths, reserving time slots, applying intensified cleaning procedures, and supplying personnel and staff with appropriate PPE. Remote working of research staff, medical physicists, and, in some cases, radiation oncologists has prevented overcrowding of shared spaces, reducing infection spread.

Published
2022

7. A multicenter LArge retrospectIve daTabase on the personalization of stereotactic ABlative radiotherapy use in lung metastases from colon-rectal cancer: The LaIT-SABR study

Author

Nicosia, L, Franceschini, D, Perrone-Congedi, F, Casamassima, F, Gerardi, M, Rigo, M, Mazzola, R, Perna, M, Scotti, V, Fodor, A, Iurato, A, Pasqualetti, F, Gadducci, G, Chiesa, S, Niespolo, R, Bruni, A, Alicino, G, Frassinelli, L, Borghetti, P, Di Marzo, A, Ravasio, A, De Bari, B, Sepulcri, M, Aiello, D, Mortellaro, G, Sangalli, C, Franceschini, M, Montesi, G, Aquilanti, F, Lunardi, G, Valdagni, R, Fazio, I, Scarzello, G, Corti, L, Vavassori, V, Maranzano, E, Magrini, S, Arcangeli, S, Gambacorta, M, Valentini, V, Paiar, F, Ramella, S, Di Muzio, N, Livi, L, Jereczek-Fossa, B, Osti, M, Scorsetti, M, Alongi, F, Nicosia L., Franceschini D., Perrone-Congedi F., Casamassima F., Gerardi M. A., Rigo M., Mazzola R., Perna M., Scotti V., Fodor A., Iurato A., Pasqualetti F., Gadducci G., Chiesa S., Niespolo R. M., Bruni A., Alicino G., Frassinelli L., Borghetti P., Di Marzo A., Ravasio A., De Bari B., Sepulcri M., Aiello D., Mortellaro G., Sangalli C., Franceschini M., Montesi G., Aquilanti F. M., Lunardi G., Valdagni R., Fazio I., Scarzello G., Corti L., Vavassori V., Maranzano E., Magrini S. M., Arcangeli S., Gambacorta M. A., Valentini V., Paiar F., Ramella S., Di Muzio N. G., Livi L., Jereczek-Fossa B. A., Osti M. F., Scorsetti M., Alongi F., Nicosia, L, Franceschini, D, Perrone-Congedi, F, Casamassima, F, Gerardi, M, Rigo, M, Mazzola, R, Perna, M, Scotti, V, Fodor, A, Iurato, A, Pasqualetti, F, Gadducci, G, Chiesa, S, Niespolo, R, Bruni, A, Alicino, G, Frassinelli, L, Borghetti, P, Di Marzo, A, Ravasio, A, De Bari, B, Sepulcri, M, Aiello, D, Mortellaro, G, Sangalli, C, Franceschini, M, Montesi, G, Aquilanti, F, Lunardi, G, Valdagni, R, Fazio, I, Scarzello, G, Corti, L, Vavassori, V, Maranzano, E, Magrini, S, Arcangeli, S, Gambacorta, M, Valentini, V, Paiar, F, Ramella, S, Di Muzio, N, Livi, L, Jereczek-Fossa, B, Osti, M, Scorsetti, M, Alongi, F, Nicosia L., Franceschini D., Perrone-Congedi F., Casamassima F., Gerardi M. A., Rigo M., Mazzola R., Perna M., Scotti V., Fodor A., Iurato A., Pasqualetti F., Gadducci G., Chiesa S., Niespolo R. M., Bruni A., Alicino G., Frassinelli L., Borghetti P., Di Marzo A., Ravasio A., De Bari B., Sepulcri M., Aiello D., Mortellaro G., Sangalli C., Franceschini M., Montesi G., Aquilanti F. M., Lunardi G., Valdagni R., Fazio I., Scarzello G., Corti L., Vavassori V., Maranzano E., Magrini S. M., Arcangeli S., Gambacorta M. A., Valentini V., Paiar F., Ramella S., Di Muzio N. G., Livi L., Jereczek-Fossa B. A., Osti M. F., Scorsetti M., and Alongi F.

Abstract

Introduction: Stereotactic ablative radiotherapy (SABR) has been shown to increase survival in oligometastatic disease, but local control of colorectal metastases remains poor. We aimed to identify potential predictive factors of SBRT response through a multicenter large retrospective database and to investigate the progression to the polymetastatic disease (PMD). Material and methods: The study involved 23 centers, and was approved by the Ethical Committee (Prot. Negrar 2019-ZT). 1033 lung metastases were reported. Clinical and biological parameters were evaluated as predictive for freedom from local progression-free survival (FLP). Secondary end-point was the time to the polymetastatic conversion (tPMC). Results: Two-year FLP was 75.4%. Two-year FLP for lesions treated with a BED < 00 Gy, 100–124 Gy, and ≥125 Gy was 76.1%, 70.6%, and 94% (p = 0.000). Two-year FLP for lesion measuring ≤10 mm, 10–20 mm, and >20 mm was 79.7%, 77.1%, and 66.6% (p = 0.027). At the multivariate analysis a BED ≥125 Gy significantly reduced the risk of local progression (HR 0.24, 95%CI 0.11–0.51; p = 0.000). Median tPMC was 26.8 months. Lesions treated with BED ≥125 Gy reported a significantly longer tPMC as compared to lower BED. The median tPMC for patients treated to 1, 2–3 or 4–5 simultaneous oligometastases was 28.5, 25.4, and 9.8 months (p = 0.035). Conclusion: The present is the largest series of lung colorectal metastases treated with SABR. The results support the use of SBRT in lung oligometastatic colorectal cancer patients as it might delay the transition to PMD or offer relatively long disease-free period in selected cases. Predictive factors were identified for treatment personalization.

Published
2022

8. PO-1483 Persistent urinary symptoms and long-term quality of life after prostate cancer radiotherapy

Author

Spampinato, S., primary, Waskiewicz, J.M., additional, Avuzzi, B., additional, Garibaldi, E., additional, Faiella, A., additional, Villa, E., additional, Magli, A., additional, Cante, D., additional, Girelli, G., additional, Gatti, M., additional, Ferella, L., additional, Noris Chiorda, B., additional, Rago, L., additional, Ferrari, P., additional, Piva, C., additional, Maddalena, P., additional, Tiziana, R., additional, Valdagni, R., additional, Vavassori, V., additional, Munoz, F., additional, Sanguineti, G., additional, Di Muzio, N., additional, Kirchheiner, K., additional, Fiorino, C., additional, and Cozzarini, C., additional

Published
2023
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9. Image-guided radiotherapy (IGRT) in Lombardy, Italy: a survey by the Lombardy section of the Italian Association of Radiotherapy and Clinical Oncology (AIRO-Lombardy)

Author

Pedretti, S, De Santis, M, Vavassori, V, Bortolato, B, Colciago, R, Cagna, E, Doino, D, Cocchi, A, Gerardi, M, Alterio, D, Magrini, S, Tonoli, S, Pedretti, Sara, De Santis, Maria Carmen, Vavassori, Vittorio, Bortolato, Barbara, Colciago, Riccardo Ray, Cagna, Emanuela, Doino, Daniela Patrizia, Cocchi, Alessandra, Gerardi, Marianna Alessandra, Alterio, Daniela, Magrini, Stefano Maria, Tonoli, Sandro, Pedretti, S, De Santis, M, Vavassori, V, Bortolato, B, Colciago, R, Cagna, E, Doino, D, Cocchi, A, Gerardi, M, Alterio, D, Magrini, S, Tonoli, S, Pedretti, Sara, De Santis, Maria Carmen, Vavassori, Vittorio, Bortolato, Barbara, Colciago, Riccardo Ray, Cagna, Emanuela, Doino, Daniela Patrizia, Cocchi, Alessandra, Gerardi, Marianna Alessandra, Alterio, Daniela, Magrini, Stefano Maria, and Tonoli, Sandro

Abstract

Background: Image-guided radiation therapy (IGRT) has changed clinical practice. We proposed a survey to radiotherapy centers in Lombardy to picture the current clinical practice of its use. Research design and methods: The survey consisted of 32 multiple-choice questions, divided into five topics: type of hospital, patients treated in 2019, number of LINACs; presence of protocols and staff involved in IGRT; IGRT in stereotaxis; IGRT in non-stereotactic treatments; availability of medical and technical staff. Results: Twenty-seven directors answered (77%). Most centers (74%) have produced protocols to ensure uniformity in the IGRT process. The most widely used IGRT modality (92%) is cone-beam CT. Daily IGRT control is favored for prostate (100%), head and neck (87%), and lung (78%) neoplasms. The resident doctors can always perform supervised IGRT matching in only six centers. Radiation therapists perform IGRT controls only for some sites in 12 cases (44%) and always in 9 cases (33%). Radiation oncologists are present in real time, in most cases. Conclusions: Today, IGRT can be considered standard practice but at the price of more time-consuming procedures. A balance between a fully physician-controlled process and an increased role for specifically trained RTTs is actively being sought.

Published
2023

11. CO-03.1 - USE DOSE OF SURFACE MAPS TO IDENTIFY BLADDER SUB-REGIONS ASSOCIATED WITH LATE TOXICITIES AFTER PROSTATE CANCER RADIOTHERAPY

Author

Gioscio, E., Cicchetti, A., Iacovacci, J., Spampinato, S., Avuzzi, B., Chiorda, B. Noris, Badenchini, F., Waskiewicz, J.M., Garibaldi, E., Villa, E., Magli, A., Cante, D., Girelli, G., Gatti, M., Farella, L., Ferrari, P., Piva, C., Pavarini, M., Valdagni, R., Vavassori, V., Munoz, F., Fiorino, C., Cozzarini, C., and Rancati, T.

Published
2023
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12. Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome

Author

Vavassori, V, Mercuri, E, Marcovecchio, G, Castiello, M, Schiroli, G, Albano, L, Margulies, C, Buquicchio, F, Fontana, E, Beretta, S, Merelli, I, Cappelleri, A, Rancoita, P, Lougaris, V, Plebani, A, Kanariou, M, Lankester, A, Ferrua, F, Scanziani, E, Cotta-Ramusino, C, Villa, A, Naldini, L, Genovese, P, Vavassori V., Mercuri E., Marcovecchio G. E., Castiello M. C., Schiroli G., Albano L., Margulies C., Buquicchio F., Fontana E., Beretta S., Merelli I., Cappelleri A., Rancoita P. M. V., Lougaris V., Plebani A., Kanariou M., Lankester A., Ferrua F., Scanziani E., Cotta-Ramusino C., Villa A., Naldini L., Genovese P., Vavassori, V, Mercuri, E, Marcovecchio, G, Castiello, M, Schiroli, G, Albano, L, Margulies, C, Buquicchio, F, Fontana, E, Beretta, S, Merelli, I, Cappelleri, A, Rancoita, P, Lougaris, V, Plebani, A, Kanariou, M, Lankester, A, Ferrua, F, Scanziani, E, Cotta-Ramusino, C, Villa, A, Naldini, L, Genovese, P, Vavassori V., Mercuri E., Marcovecchio G. E., Castiello M. C., Schiroli G., Albano L., Margulies C., Buquicchio F., Fontana E., Beretta S., Merelli I., Cappelleri A., Rancoita P. M. V., Lougaris V., Plebani A., Kanariou M., Lankester A., Ferrua F., Scanziani E., Cotta-Ramusino C., Villa A., Naldini L., and Genovese P.

Abstract

Precise correction of the CD40LG gene in T cells and hematopoietic stem/progenitor cells (HSPC) holds promise for treating X-linked hyper-IgM Syndrome (HIGM1), but its actual therapeutic potential remains elusive. Here, we developed a one-size-fits-all editing strategy for effective T-cell correction, selection, and depletion and investigated the therapeutic potential of T-cell and HSPC therapies in the HIGM1 mouse model. Edited patients’ derived CD4 T cells restored physiologically regulated CD40L expression and contact-dependent B-cell helper function. Adoptive transfer of wild-type T cells into conditioned HIGM1 mice rescued antigen-specific IgG responses and protected mice from a disease-relevant pathogen. We then obtained ~ 25% CD40LG editing in long-term repopulating human HSPC. Transplanting such proportion of wild-type HSPC in HIGM1 mice rescued immune functions similarly to T-cell therapy. Overall, our findings suggest that autologous edited T cells can provide immediate and substantial benefits to HIGM1 patients and position T-cell ahead of HSPC gene therapy because of easier translation, lower safety concerns and potentially comparable clinical benefits.

Published
2021

13. Back to (new) normality—A CODRAL/AIRO-L survey on cancer radiotherapy in Lombardy during Italian COVID-19 phase 2

Author

Jereczek-Fossa, B, Pepa, M, Marvaso, G, Isaksson, J, Soatti, C, Cazzaniga, L, Ivaldi, G, Amadori, M, Antognoni, P, Arcangeli, S, Buffoli, A, Beltramo, G, Bignardi, M, Bracelli, S, Bruschieri, L, Castiglioni, S, Catalano, G, Di Muzio, N, Fallai, C, Fariselli, L, Filippi, A, Gramaglia, A, Italia, C, Lombardi, F, Magrini, S, Nava, S, Orlandi, E, Pasinetti, N, Sbicego, E, Scandolaro, L, Scorsetti, M, Stiglich, F, Tortini, R, Valdagni, R, Vavassori, V, Tonoli, S, Palazzi, M, Jereczek-Fossa B. A., Pepa M., Marvaso G., Isaksson J. L., Soatti C. P., Cazzaniga L. F., Ivaldi G. B., Amadori M., Antognoni P., Arcangeli S., Buffoli A., Beltramo G., Bignardi M., Bracelli S., Bruschieri L., Castiglioni S., Catalano G., Di Muzio N., Fallai C., Fariselli L., Filippi A. R., Gramaglia A., Italia C., Lombardi F., Magrini S. M., Nava S., Orlandi E., Pasinetti N., Sbicego E. L., Scandolaro L., Scorsetti M., Stiglich F., Tortini R., Valdagni R., Vavassori V., Tonoli S., Palazzi M. F., Jereczek-Fossa, B, Pepa, M, Marvaso, G, Isaksson, J, Soatti, C, Cazzaniga, L, Ivaldi, G, Amadori, M, Antognoni, P, Arcangeli, S, Buffoli, A, Beltramo, G, Bignardi, M, Bracelli, S, Bruschieri, L, Castiglioni, S, Catalano, G, Di Muzio, N, Fallai, C, Fariselli, L, Filippi, A, Gramaglia, A, Italia, C, Lombardi, F, Magrini, S, Nava, S, Orlandi, E, Pasinetti, N, Sbicego, E, Scandolaro, L, Scorsetti, M, Stiglich, F, Tortini, R, Valdagni, R, Vavassori, V, Tonoli, S, Palazzi, M, Jereczek-Fossa B. A., Pepa M., Marvaso G., Isaksson J. L., Soatti C. P., Cazzaniga L. F., Ivaldi G. B., Amadori M., Antognoni P., Arcangeli S., Buffoli A., Beltramo G., Bignardi M., Bracelli S., Bruschieri L., Castiglioni S., Catalano G., Di Muzio N., Fallai C., Fariselli L., Filippi A. R., Gramaglia A., Italia C., Lombardi F., Magrini S. M., Nava S., Orlandi E., Pasinetti N., Sbicego E. L., Scandolaro L., Scorsetti M., Stiglich F., Tortini R., Valdagni R., Vavassori V., Tonoli S., and Palazzi M. F.

Abstract

Background: Italy experienced one of the world’s severest COVID-19 outbreak, with Lombardy being the most afflicted region. However, the imposed safety measures allowed to flatten the epidemic curve and hence to ease the restrictions and inaugurate, on the 4th of May 2020, the Italian phase (P) 2 of the pandemic. The present survey study, endorsed by CODRAL and AIRO-L, aimed to assess how radiotherapy (RT) departments in Lombardy have dealt with the recovery. Materials and methods: A questionnaire dealing with the management of pandemic was developed online and sent to all CODRAL Directors on the 10th of June 2020. Answers were collected in full anonymity one week after. Results: All the 33 contacted RT facilities (100%) responded to the survey. Despite the scale of the pandemic, during P1 14 (42.4%) centres managed to safely continue the activity (≤ 10% reduction). During P2, 10 (30.3%) centres fully recovered and 14 (42.4%) reported an increase. Nonetheless, 6 (18.2%) declared no changes and, interestingly, 3 (9.1%) reduced activities. Overall, 21 centres (63.6%) reported suspected or positive cases within healthcare workforce since the beginning of the pandemic. Staff units were quarantined in 19 (57.6%) and 6 (18.2%) centres throughout P1 and P2, respectively. In the two phases, about two thirds centres registered positive or suspected cases amongst patients. Conclusion: The study revealed a particular attention to anti-contagion measures and a return to normal or even higher clinical workload in most RT centres in Lombardy, necessary to carry out current and previously deferred treatments.

Published
2020

14. Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking

Author

Ferrari, S, Jacob, A, Beretta, S, Unali, G, Albano, L, Vavassori, V, Cittaro, D, Lazarevic, D, Brombin, C, Cugnata, F, Kajaste-Rudnitski, A, Merelli, I, Genovese, P, Naldini, L, Ferrari S., Jacob A., Beretta S., Unali G., Albano L., Vavassori V., Cittaro D., Lazarevic D., Brombin C., Cugnata F., Kajaste-Rudnitski A., Merelli I., Genovese P., Naldini L., Ferrari, S, Jacob, A, Beretta, S, Unali, G, Albano, L, Vavassori, V, Cittaro, D, Lazarevic, D, Brombin, C, Cugnata, F, Kajaste-Rudnitski, A, Merelli, I, Genovese, P, Naldini, L, Ferrari S., Jacob A., Beretta S., Unali G., Albano L., Vavassori V., Cittaro D., Lazarevic D., Brombin C., Cugnata F., Kajaste-Rudnitski A., Merelli I., Genovese P., and Naldini L.

Abstract

Targeted gene editing in hematopoietic stem cells (HSCs) is a promising treatment for several diseases. However, the limited efficiency of homology-directed repair (HDR) in HSCs and the unknown impact of the procedure on clonal composition and dynamics of transplantation have hampered clinical translation. Here, we apply a barcoding strategy to clonal tracking of edited cells (BAR-Seq) and show that editing activates p53, which substantially shrinks the HSC clonal repertoire in hematochimeric mice, although engrafted edited clones preserve multilineage and self-renewing capacity. Transient p53 inhibition restored polyclonal graft composition. We increased HDR efficiency by forcing cell-cycle progression and upregulating components of the HDR machinery through transient expression of the adenovirus 5 E4orf6/7 protein, which recruits the cell-cycle controller E2F on its target genes. Combined E4orf6/7 expression and p53 inhibition resulted in HDR editing efficiencies of up to 50% in the long-term human graft, without perturbing repopulation and self-renewal of edited HSCs. This enhanced protocol should broaden applicability of HSC gene editing and pave its way to clinical translation.

Published
2020

15. COVID-19 Outbreak and Cancer Radiotherapy Disruption in Lombardy, Northern Italy

Author

Jereczek-Fossa, B, Palazzi, M, Soatti, C, Cazzaniga, L, Ivaldi, G, Pepa, M, Amadori, M, Antognoni, P, Arcangeli, S, Buffoli, A, Beltramo, G, Berlinghieri, S, Bignardi, M, Bracelli, S, Bruschieri, L, Castiglioni, S, Catalano, G, Di Muzio, N, Fallai, C, Fariselli, L, Filippi, A, Gramaglia, A, Italia, C, Lombardi, F, Magrini, S, Nava, S, Orlandi, E, Pasinetti, N, Sbicego, E, Scandolaro, L, Scorsetti, M, Stiglich, F, Tonoli, S, Tortini, R, Valdagni, R, Vavassori, V, Marvaso, G, Jereczek-Fossa B. A., Palazzi M. F., Soatti C. P., Cazzaniga L. F., Ivaldi G. B., Pepa M., Amadori M., Antognoni P., Arcangeli S., Buffoli A., Beltramo G., Berlinghieri S., Bignardi M., Bracelli S., Bruschieri L., Castiglioni S., Catalano G., Di Muzio N., Fallai C., Fariselli L., Filippi A. R., Gramaglia A., Italia C., Lombardi F., Magrini S. M., Nava S., Orlandi E., Pasinetti N., Sbicego E. L., Scandolaro L., Scorsetti M., Stiglich F., Tonoli S., Tortini R., Valdagni R., Vavassori V., Marvaso G., Jereczek-Fossa, B, Palazzi, M, Soatti, C, Cazzaniga, L, Ivaldi, G, Pepa, M, Amadori, M, Antognoni, P, Arcangeli, S, Buffoli, A, Beltramo, G, Berlinghieri, S, Bignardi, M, Bracelli, S, Bruschieri, L, Castiglioni, S, Catalano, G, Di Muzio, N, Fallai, C, Fariselli, L, Filippi, A, Gramaglia, A, Italia, C, Lombardi, F, Magrini, S, Nava, S, Orlandi, E, Pasinetti, N, Sbicego, E, Scandolaro, L, Scorsetti, M, Stiglich, F, Tonoli, S, Tortini, R, Valdagni, R, Vavassori, V, Marvaso, G, Jereczek-Fossa B. A., Palazzi M. F., Soatti C. P., Cazzaniga L. F., Ivaldi G. B., Pepa M., Amadori M., Antognoni P., Arcangeli S., Buffoli A., Beltramo G., Berlinghieri S., Bignardi M., Bracelli S., Bruschieri L., Castiglioni S., Catalano G., Di Muzio N., Fallai C., Fariselli L., Filippi A. R., Gramaglia A., Italia C., Lombardi F., Magrini S. M., Nava S., Orlandi E., Pasinetti N., Sbicego E. L., Scandolaro L., Scorsetti M., Stiglich F., Tonoli S., Tortini R., Valdagni R., Vavassori V., and Marvaso G.

Published
2020

16. PD-0414 Trend over time of patient-reported QoL domains after pelvic nodal irradiation for prostate cancer

Author

Faiella, A., primary, Gebbia, A., additional, Villa, E., additional, Waskiewicz, J.M., additional, Magli, A., additional, Avuzzi, B., additional, Garibaldi, E., additional, Cante, D., additional, Girelli, G., additional, Gatti, M., additional, Ferella, L., additional, Noris Chiorda, B., additional, Rago, L., additional, Ferrari, P., additional, Bresolin, A., additional, Piva, C., additional, Badenchini, F., additional, Rancati, T., additional, Valdagni, R., additional, Vavassori, V., additional, Munoz, F., additional, Sanguineti, G., additional, Di Muzio, N., additional, Fiorino, C., additional, and Cozzarini, C., additional

Published
2022
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17. OC-0602 A pREDictive model of polymetastatic disease on oligometastatic colorectal cancer: the RED LaIT-SABR

Author

Nicosia, L., primary, Franceschini, D., additional, Perrone Congedi, F., additional, Casamassima, F., additional, Gerardi, M.A., additional, Rigo, M., additional, Mazzola, R., additional, Perna, M., additional, Scotti, V., additional, Fodor, A., additional, Iurato, A., additional, Pasqualetti, F., additional, Gadducci, G., additional, Chiesa, S., additional, Niespolo, R.M., additional, Bruni, A., additional, Alicino, G., additional, Frassinelli, L., additional, Borghetti, P., additional, Di Marzo, A., additional, Ravasio, A., additional, De Bari, B., additional, Sepulcri, M., additional, Aiello, D., additional, Mortellaro, G., additional, Sangalli, C., additional, Franceschini, M., additional, Montesi, G., additional, Aquilanti, F.M., additional, Lunardi, G., additional, Valdagni, R., additional, Fazio, I., additional, Corti, L., additional, Vavassori, V., additional, Maranzano, E., additional, Magrini, S.M., additional, Arcangeli, S., additional, Valentini, V., additional, Paiar, F., additional, Ramella, S., additional, Di Muzio, N.G., additional, Livi, L., additional, Jereczek- Fossa, B.A., additional, Osti, M.F., additional, Scorsetti, M., additional, and Alongi, F., additional

Published
2022
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18. PD-0415 Pelvic RT in prostate cancer: late intestinal toxicity is modulated by severity of acute symptoms

Author

Gebbia, A., primary, Munoz, F., additional, Magli, A., additional, Cante, D., additional, Garibaldi, E., additional, Noris Chiorda, B., additional, Girelli, G., additional, Villa, E., additional, Faiella, A., additional, Waskiewicz, J.M., additional, Avuzzi, B., additional, Pastorino, A., additional, Moretti, E., additional, Rago, L., additional, Bresolin, A., additional, Bianconi, C., additional, Badenchini, F., additional, Rancati, T., additional, Valdagni, R., additional, Vavassori, V., additional, Gatti, M., additional, Sanguineti, G., additional, Di Muzio, N., additional, Fiorino, C., additional, and Cozzarini, C., additional

Published
2022
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19. A multicenter LArge retrospectIve daTabase on the personalization of stereotactic ABlative radiotherapy use in lung metastases from colon-rectal cancer: The LaIT-SABR study

Author

Nicosia, L., primary, Franceschini, D., additional, Perrone-Congedi, F., additional, Casamassima, F., additional, Gerardi, M.A., additional, Rigo, M., additional, Mazzola, R., additional, Perna, M., additional, Scotti, V., additional, Fodor, A., additional, Iurato, A., additional, Pasqualetti, F., additional, Gadducci, G., additional, Chiesa, S., additional, Niespolo, R.M., additional, Bruni, A., additional, Alicino, G., additional, Frassinelli, L., additional, Borghetti, P., additional, Di Marzo, A., additional, Ravasio, A., additional, De Bari, B., additional, Sepulcri, M., additional, Aiello, D., additional, Mortellaro, G., additional, Sangalli, C., additional, Franceschini, M., additional, Montesi, G., additional, Aquilanti, F.M., additional, Lunardi, G., additional, Valdagni, R., additional, Fazio, I., additional, Scarzello, Giovanni, additional, Corti, L., additional, Vavassori, V., additional, Maranzano, E., additional, Magrini, S.M., additional, Arcangeli, S., additional, Gambacorta, Maria Antonietta, additional, Valentini, V., additional, Paiar, F., additional, Ramella, S., additional, Di Muzio, N.G., additional, Livi, L., additional, Jereczek-Fossa, B.A., additional, Osti, M.F., additional, Scorsetti, M., additional, and Alongi, F., additional

Published
2022
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20. Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response

Author

Schiroli, G, Conti, A, Ferrari, S, della Volpe, L, Jacob, A, Albano, L, Beretta, S, Calabria, A, Vavassori, V, Gasparini, P, Salataj, E, Ndiaye-Lobry, D, Brombin, C, Chaumeil, J, Montini, E, Merelli, I, Genovese, P, Naldini, L, Di Micco, R, Schiroli G., Conti A., Ferrari S., della Volpe L., Jacob A., Albano L., Beretta S., Calabria A., Vavassori V., Gasparini P., Salataj E., Ndiaye-Lobry D., Brombin C., Chaumeil J., Montini E., Merelli I., Genovese P., Naldini L., Di Micco R., Schiroli, G, Conti, A, Ferrari, S, della Volpe, L, Jacob, A, Albano, L, Beretta, S, Calabria, A, Vavassori, V, Gasparini, P, Salataj, E, Ndiaye-Lobry, D, Brombin, C, Chaumeil, J, Montini, E, Merelli, I, Genovese, P, Naldini, L, Di Micco, R, Schiroli G., Conti A., Ferrari S., della Volpe L., Jacob A., Albano L., Beretta S., Calabria A., Vavassori V., Gasparini P., Salataj E., Ndiaye-Lobry D., Brombin C., Chaumeil J., Montini E., Merelli I., Genovese P., Naldini L., and Di Micco R.

Abstract

Precise gene editing in hematopoietic stem and progenitor cells (HSPCs) holds promise for treating genetic diseases. However, responses triggered by programmable nucleases in HSPCs are poorly characterized and may negatively impact HSPC engraftment and long-term repopulation capacity. Here, we induced either one or several DNA double-stranded breaks (DSBs) with optimized zinc-finger and CRISPR/Cas9 nucleases and monitored DNA damage response (DDR) foci induction, cell-cycle progression, and transcriptional responses in HSPC subpopulations, with up to single-cell resolution. p53-mediated DDR pathway activation was the predominant response to even single-nuclease-induced DSBs across all HSPC subtypes analyzed. Excess DSB load and/or adeno-associated virus (AAV)-mediated delivery of DNA repair templates induced cumulative p53 pathway activation, constraining proliferation, yield, and engraftment of edited HSPCs. However, functional impairment was reversible when DDR burden was low and could be overcome by transient p53 inhibition. These findings provide molecular and functional evidence for feasible and seamless gene editing in HSPCs. Precise gene editing has the potential to treat immune and hematological diseases. Genovese, Naldini, Di Micco, and colleagues now show that gene-editing procedures are well tolerated by hematopoietic stem cells and provide molecular evidence of the feasibility of seamless gene editing, strengthening translation of such approaches to humans.

Published
2019

22. Concomitant immuno-radiotherapy in metastatic renal cell carcinoma: multicenter analysis

Author

Francolini, G., primary, Di Cataldo, V., additional, Detti, B., additional, Loi, M., additional, Ghirardelli, P., additional, Vavassori, V., additional, Nicosia, L., additional, Alongi, F., additional, Triggiani, L., additional, La Mattina, S., additional, Allegra, A.G., additional, Cerbai, C., additional, Aquilano, M., additional, Burchini, L., additional, Mattioli, C., additional, Peruzzi, A., additional, Lucidi, S., additional, Scoccimarro, E., additional, Mariotti, M., additional, Salvestrini, V., additional, Stocchi, G., additional, Ciccone, L.P., additional, Desideri, I., additional, and Livi, L., additional

Published
2021
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23. PD-0769 Patient-reported acute intestinal toxicity and impact on patient QoL after WPRT for prostate cancer

Author

Noris Chiorda, B., primary, Munoz, F., additional, Sanguineti, G., additional, Cante, D., additional, Waskiewicz, J.M., additional, Avuzzi, B., additional, Vavassori, V., additional, Gatti, M., additional, Girelli, G., additional, Magli, A., additional, Pastorino, A., additional, Ferella, L., additional, Faiella, A., additional, Piva, C., additional, Ferrari, P., additional, Villa, E., additional, Farina, B., additional, Moretti, E., additional, Rancati, T., additional, Badenchini, F., additional, Bresolin, A., additional, Valdagni, R., additional, Di Muzio, N., additional, Fiorino, C., additional, and Cozzarini, C., additional

Published
2021
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24. PH-0108 New dose-volume constraints for patient-reported acute bowel toxicity symptoms in whole pelvis IMRT

Author

Bresolin, A., primary, Faiella, A., additional, Garibaldi, E., additional, Munoz, F., additional, Cante, D., additional, Vavassori, V., additional, Waskiewicz, J.M., additional, Girellli, G., additional, Avuzzi, B., additional, Villa, E., additional, Magli, A., additional, Noris Chiorda, B., additional, Gatti, M., additional, Ferella, L., additional, Maggio, A., additional, Landoni, V., additional, Aimonetto, S., additional, Sini, C., additional, Rancati, T., additional, Sanguineti, G., additional, Valdagni, R., additional, Di Muzio, N., additional, Cozzarini, C., additional, and Fiorino, C., additional

Published
2021
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25. PO-1363 Prediction of urinary toxicity after prostate cancer RT: long term evaluation

Author

Rancati, T., primary, Cicchetti, A., additional, Gioscio, E., additional, Avuzzi, B., additional, Noris Chiorda, B., additional, Valdagni, R., additional, Garibaldi, E., additional, Cante, D., additional, Vavassori, V., additional, Girelli, G., additional, Degli Esposti, C., additional, Iotti, C., additional, Fiorino, C., additional, and Cozzarini, C., additional

Published
2021
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26. PO-1342 Trends and predictors of worsening at RT end of anxiety and depression during RT for prostate cancer

Author

Cante, D., primary, Avuzzi, B., additional, Waskiewicz, J.M., additional, Faiella, A., additional, Villa, E., additional, Ferella, L., additional, Garibaldi, E., additional, Magli, A., additional, Noris Chiorda, B., additional, Girelli, G., additional, Olivetta, E., additional, Piva, C., additional, Gatti, M., additional, Ferrari, P., additional, Moretti, E., additional, Sanguineti, G., additional, Vavassori, V., additional, Munoz, F., additional, Rancati, T., additional, Badenchini, F., additional, Bresolin, A., additional, Valdagni, R., additional, Di Muzio, N., additional, Fiorino, C., additional, and Cozzarini, C., additional

Published
2021
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27. PO-1345 Symptoms affecting Emotional, Systemic and Social Domains 2 years after RT for prostate cancer

Author

Garibaldi, E., primary, Faiella, A., additional, Villa, E., additional, Magli, A., additional, Cante, D., additional, Avuzzi, B., additional, Waskiewicz, J.M., additional, Ferella, L., additional, Noris Chiorda, B., additional, Girelli, G., additional, Pastorino, A., additional, Piva, C., additional, Gatti, M., additional, Ferrari, P., additional, Maggio, A., additional, Olivetta, E., additional, Sanguineti, G., additional, Vavassori, V., additional, Munoz, F., additional, Rancati, T., additional, Badenchini, F., additional, Bresolin, A., additional, Valdagni, R., additional, Di Muzio, N., additional, Fiorino, C., additional, and Cozzarini, C., additional

Published
2021
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28. PD-0767 Predictors of urinary incontinence 2 years after RT with different intents for prostate cancer

Author

Cozzarini, C., primary, Sanguineti, G., additional, Vavassori, V., additional, Munoz, F., additional, Avuzzi, B., additional, Garibaldi, E., additional, Cante, D., additional, Waskiewicz, J.M., additional, Magli, A., additional, Faiella, A., additional, Villa, E., additional, Ferella, L., additional, Gatti, M., additional, Noris Chiorda, B., additional, Piva, C., additional, Ferrari, P., additional, Rancati, T., additional, Badenchini, F., additional, Girelli, G., additional, Moretti, E., additional, Valdagni, R., additional, Bresolin, A., additional, Di Muzio, N., additional, and Fiorino, C., additional

Published
2021
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29. PD-0849 Concomitant Nivolumab and RT in metastatic kidney cancer. Benefit of ablative vs palliative approach

Author

Francolini, G., primary, Di Cataldo, V., additional, Detti, B., additional, Loi, M., additional, Ghirardelli, P., additional, Vavassori, V., additional, Nicosia, L., additional, Alongi, F., additional, Triggiani, L., additional, La Mattina, S., additional, Allegra, A.G., additional, Scoccimarro, E., additional, Aquilano, M., additional, Lucidi, S., additional, Valzano, M., additional, Peruzzi, A., additional, Morelli, I., additional, Mariotti, M., additional, Salvestrini, V., additional, Stocchi, G., additional, Ciccone, L.P., additional, Desideri, I., additional, and Livi, L., additional

Published
2021
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33. A Multicenter Large Retrospective Database On The Personalization Of Stereotactic Ablative Radiotherapy For Lung Metastases From Colon-rectal Cancer: Early Results From The LaIT-SABR Study

Author

Nicosia, L., primary, Rigo, M., additional, Franceschini, D., additional, Scorsetti, M., additional, Perrone, F., additional, Osti, M.F., additional, Ravasio, A., additional, Vavassori, V., additional, Borghetti, P., additional, Magrini, S., additional, Bruni, A., additional, Frassinelli, L., additional, Lohr, F., additional, Di Marzo, A., additional, Maranzano, E., additional, Slimani, S., additional, De Bari, B., additional, Mazzola, R., additional, and Alongi, F., additional

Published
2020
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34. PD-0059: Patient-reported baseline incontinence at post-prostatectomy RT: its dependence on time from surgery

Author

Munoz, F., primary, Sanguineti, G., additional, Gabriele, P., additional, Bresolin, A., additional, Cante, D., additional, Vavassori, V., additional, Waskiewicz, J.M., additional, Girelli, G., additional, Avuzzi, B., additional, Faiella, A., additional, Garibaldi, E., additional, Villa, E., additional, Magli, A., additional, Chiorda, B.N., additional, Gatti, M., additional, Rancati, T., additional, Valdagni, R., additional, Di Muzio, N., additional, Fiorino, C., additional, and Cozzarini, C., additional

Published
2020
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35. PD-0668: Longitudinal analysis of patient-reported urinary incontinence 2yr after post-prostatectomy RT

Author

Garibaldi, E., primary, Bresolin, A., additional, Cante, D., additional, Sanguineti, G., additional, Munoz, F., additional, Vavassori, V., additional, Waskiewicz, J.M., additional, Girelli, G., additional, Avuzzi, B., additional, Faiella, A., additional, Villa, E., additional, Magli, A., additional, Chiorda, B.N., additional, Gabriele, P., additional, Gatti, M., additional, Rancati, T., additional, Valdagni, R., additional, Di Muzio, N., additional, Fiorino, C., additional, and Cozzarini, C., additional

Published
2020
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36. PH-0366: Predictors of incontinence 2yr after post-prostatectomy RT: evidence of dose & fractionation effects

Author

Bresolin, A., primary, Garibaldi, E., additional, Faiella, A., additional, Cante, D., additional, Vavassori, V., additional, Waskiewicz, J.M., additional, Girelli, G., additional, Avuzzi, B., additional, Villa, E., additional, Magli, A., additional, Chiorda, B.N., additional, Munoz, F., additional, Sanguineti, G., additional, Gabriele, P., additional, Gatti, M., additional, Rancati, T., additional, Valdagni, R., additional, Di Muzio, N., additional, Fiorino, C., additional, and Cozzarini, C., additional

Published
2020
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37. 492P A multicenter LArge retrospectIve daTabase on the personalization of Stereotactic ABlative Radiotherapy for lung metastases from colorectal cancer: Early results from the LaIT-SABR study

Author

Nicosia, L., primary, Rigo, M., additional, Franceschini, D., additional, Scorsetti, M., additional, Congedi, F. Perrone, additional, Osti, M.F., additional, Ravasio, A., additional, Vavassori, V., additional, Borghetti, P., additional, Magrini, S.M., additional, Bruni, A., additional, Frassinelli, L., additional, Lohr, F., additional, Di Marzo, A., additional, Maranzano, E., additional, De Bari, B., additional, Mazzola, R., additional, and Alongi, F., additional

Published
2020
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38. COVID-19 Outbreak and Cancer Radiotherapy Disruption in Lombardy, Northern Italy

Author

Jereczek-Fossa, B.A., primary, Palazzi, M.F., additional, Soatti, C.P., additional, Cazzaniga, L.F., additional, Ivaldi, G.B., additional, Pepa, M., additional, Amadori, M., additional, Antognoni, P., additional, Arcangeli, S., additional, Buffoli, A., additional, Beltramo, G., additional, Berlinghieri, S., additional, Bignardi, M., additional, Bracelli, S., additional, Bruschieri, L., additional, Castiglioni, S., additional, Catalano, G., additional, Di Muzio, N., additional, Fallai, C., additional, Fariselli, L., additional, Filippi, A.R., additional, Gramaglia, A., additional, Italia, C., additional, Lombardi, F., additional, Magrini, S.M., additional, Nava, S., additional, Orlandi, E., additional, Pasinetti, N., additional, Sbicego, E.L., additional, Scandolaro, L., additional, Scorsetti, M., additional, Stiglich, F., additional, Tonoli, S., additional, Tortini, R., additional, Valdagni, R., additional, Vavassori, V., additional, and Marvaso, G., additional

Published
2020
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39. INTENSITY MODULATED IMAGE GUIDED RADIOTHERAPY FOR ELDERLY PATIENTS WITH ANAL CANCER

Author

Motta, M, Ghirardelli, P., Villa, E., Ravasio, A., Squadroni, M., Iaculli, A., Gambirasio, A., Locatelli, F., Trombetta, L., Salmoiraghi, P., Pezzini, D., Bonanomi, C, Goletti, O., and Bombardieri, E. Vavassori V.

Subjects
RADIOTERAPIA, CANCRO DEL RETTO, ANZIANO, CANCRO DEL RETTO, ANZIANO, RADIOTERAPIA
Published
2019

40. Monitoring Patients with Metastatic Hormone-Sensitive and Metastatic Castration-Resistant Prostate Cancer: A Multidisciplinary Consensus Document

Author

Lapini, A, Caffo, O, Pappagallo, G, Iacovelli, R, D'Angelillo, R, Vavassori, V, Ceccarelli, R, Bracarda, S, Jereczek-Fossa, B, Da Pozzo, L, Conti, G, Lapini, Alberto, Caffo, Orazio, Pappagallo, Giovanni, Iacovelli, Roberto, D'Angelillo, Rolando Maria, Vavassori, Vittorio, Ceccarelli, Roberta, Bracarda, Sergio, Jereczek-Fossa, Barbara Alicja, Da Pozzo, Luigi, Conti, Giario Natale, Lapini, A, Caffo, O, Pappagallo, G, Iacovelli, R, D'Angelillo, R, Vavassori, V, Ceccarelli, R, Bracarda, S, Jereczek-Fossa, B, Da Pozzo, L, Conti, G, Lapini, Alberto, Caffo, Orazio, Pappagallo, Giovanni, Iacovelli, Roberto, D'Angelillo, Rolando Maria, Vavassori, Vittorio, Ceccarelli, Roberta, Bracarda, Sergio, Jereczek-Fossa, Barbara Alicja, Da Pozzo, Luigi, and Conti, Giario Natale

Abstract

Background: The availability of a number of agents that are efficacious in patients with metastatic prostate cancer (mPC) has led to them being used sequentially, and this has prolonged patient survival. However, in order to maximize their efficacy, clinicians need to be able to obtain a reliable picture of disease evolution by means of monitoring procedures. Methods: As the intensive monitoring protocols used in pivotal trials cannot be adopted in everyday clinical practice and there is no agreement among the available guidelines, a multidisciplinary panel of Italian experts met to develop recommendations for monitoring mPC patients using a modified Delphi method. Results: The consensus project considered methods of clinically, radiographically, and biochemically monitoring patients with metastatic hormone-sensitive and metastatic castration-resistant prostate cancer undergoing chemotherapy and/or hormonal treatment. The panelists also considered the methods and timing of monitoring castration levels, bone health, and the metabolic syndrome during androgen deprivation therapy. Conclusions: The recommendations, which were drawn up by experts following a formal and validated consensus procedure, will help clinicians face the everyday challenges of monitoring metastatic prostate cancer patients.

Published
2019

41. Guidelines on prostate carcinoma - AIRO, 2016

Author

Santoni, R, Arcangeli, S, Ingrosso, G, Antognoni, P, Mazzeo, E, D'Angelillo, R, Buglione, M, Borghesi, S, Petitti, T, Orecchia, R, Russi, E, Alitto, A, Alongi, F, Augurio, A, Bellavita, R, Bertoni, F, Bonetta, A, Bruni, A, Cagna, E, Cazzaniga, L, Corvo, R, D'Agostino, G, D'Amico, R, Detti, B, De Renzi, F, Fabrini, M, Fersino, S, Frascino, V, Gambarini, S, Genovesi, D, Grazioli, L, Guarneri, A, Jereczek-Fossa, B, Lancia, A, Livi, L, Magrini, S, Mantini, G, Mignogna, M, Mirri, M, Palumbo, I, Pergolizzi, S, Silvestro, G, Rubino, L, Tagliagambe, A, Tonoli, S, Valdagni, R, Vavassori, V, Vinciguerra, A, Santoni R., Arcangeli S., Ingrosso G., Antognoni P., Mazzeo E., D'angelillo R. M., Buglione M., Borghesi S., Petitti T., Orecchia R., Russi E., Alitto A., Alongi F., Augurio A., Bellavita R., Bertoni F., Bonetta A., Bruni A., Cagna E., Cazzaniga L. F., Corvo R., D'agostino G., D'amico R., Detti B., De Renzi F., Fabrini M. G., Fersino S., Frascino V., Gambarini S., Genovesi D., Grazioli L., Guarneri A., Jereczek-Fossa B. A., Lancia A., Livi L., Magrini S. M., Mantini G., Mignogna M., Mirri M. A., Palumbo I., Pergolizzi S., Silvestro G., Rubino L., Tagliagambe A., Tonoli S., Valdagni R., Vavassori V., Vinciguerra A., Santoni, R, Arcangeli, S, Ingrosso, G, Antognoni, P, Mazzeo, E, D'Angelillo, R, Buglione, M, Borghesi, S, Petitti, T, Orecchia, R, Russi, E, Alitto, A, Alongi, F, Augurio, A, Bellavita, R, Bertoni, F, Bonetta, A, Bruni, A, Cagna, E, Cazzaniga, L, Corvo, R, D'Agostino, G, D'Amico, R, Detti, B, De Renzi, F, Fabrini, M, Fersino, S, Frascino, V, Gambarini, S, Genovesi, D, Grazioli, L, Guarneri, A, Jereczek-Fossa, B, Lancia, A, Livi, L, Magrini, S, Mantini, G, Mignogna, M, Mirri, M, Palumbo, I, Pergolizzi, S, Silvestro, G, Rubino, L, Tagliagambe, A, Tonoli, S, Valdagni, R, Vavassori, V, Vinciguerra, A, Santoni R., Arcangeli S., Ingrosso G., Antognoni P., Mazzeo E., D'angelillo R. M., Buglione M., Borghesi S., Petitti T., Orecchia R., Russi E., Alitto A., Alongi F., Augurio A., Bellavita R., Bertoni F., Bonetta A., Bruni A., Cagna E., Cazzaniga L. F., Corvo R., D'agostino G., D'amico R., Detti B., De Renzi F., Fabrini M. G., Fersino S., Frascino V., Gambarini S., Genovesi D., Grazioli L., Guarneri A., Jereczek-Fossa B. A., Lancia A., Livi L., Magrini S. M., Mantini G., Mignogna M., Mirri M. A., Palumbo I., Pergolizzi S., Silvestro G., Rubino L., Tagliagambe A., Tonoli S., Valdagni R., Vavassori V., and Vinciguerra A.

Published
2016

42. PO-0850 Comparison of self-reported acute urinary incontinence in pts treated with adjuvant or salvage IMRT

Author

Munoz, F., primary, Cante, D., additional, Garibaldi, E., additional, Peruzzo, A., additional, Petrucci, E., additional, Delmastro, E., additional, Sanguineti, G., additional, Faiella, A., additional, Avuzzi, B., additional, Chiorda, B. Noris, additional, Giandini, T., additional, Vavassori, V., additional, Villa, E., additional, Girelli, G., additional, Farina, B., additional, Waskiewicz, J.M., additional, Magli, A., additional, Moretti, E., additional, Valdagni, R., additional, Bianconi, C., additional, Badenchini, F., additional, Di Muzio, N., additional, Rancati, T., additional, Fiorino, C., additional, and Cozzarini, C., additional

Published
2019
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43. PO-0851 Quality of life after whole pelvis RT for prostate cancer: results from a prospective study

Author

Sanguineti, G., primary, Cante, D., additional, Munoz, F., additional, Faiella, A., additional, Petrucci, E., additional, Peruzzo, A., additional, Garibaldi, E., additional, Gabriele, P., additional, Avuzzi, B., additional, Giandini, T., additional, Chiorda, B. Noris, additional, Vavassori, V., additional, Villa, E., additional, Salmoiraghi, P., additional, Girelli, G., additional, Waskiewicz, J.M., additional, Magli, A., additional, Moretti, E., additional, Valdagni, R., additional, Bianconi, C., additional, Badenchini, F., additional, Di Muzio, N., additional, Rancati, T., additional, Fiorino, C., additional, and Cozzarini, C., additional

Published
2019
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44. Comparison of self-reported acute urinary incontinence in patients treated with adjuvant or salvage post-prostatectomy intensity modulated-radiotherapy (IMRT)

Author

Munoz, F., primary, Cante, D., additional, Garibaldi, E., additional, Sanguineti, G., additional, Faiella, A., additional, Avuzzi, B., additional, Noris Chiorda, B., additional, Vavassori, V., additional, Villa, E., additional, Girelli, G., additional, Waskiewicz, J.M., additional, Magli, A., additional, Badenchini, F., additional, Bianconi, C., additional, Valdagni, R., additional, Di Muzio, N., additional, Rancati, T., additional, Fiorino, C., additional, Tutolo, M., additional, Fossati, N., additional, Gandaglia, G., additional, Briganti, A., additional, Montorsi, F., additional, and Cozzarini, C., additional

Published
2019
Full Text
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45. Guidelines on prostate carcinoma - AIRO, 2016

Author

Santoni R., Arcangeli S., Ingrosso G., Antognoni P., Mazzeo E., D'angelillo R. M., Buglione M., Borghesi S., Petitti T., Orecchia R., Russi E., Alitto A., Alongi F., Augurio A., Bellavita R., Bertoni F., Bonetta A., Bruni A., Cagna E., Cazzaniga L. F., Corvo R., D'agostino G., D'amico R., Detti B., De Renzi F., Fabrini M. G., Fersino S., Frascino V., Gambarini S., Genovesi D., Grazioli L., Guarneri A., Jereczek-Fossa B. A., Lancia A., Livi L., Magrini S. M., Mantini G., Mignogna M., Mirri M. A., Palumbo I., Pergolizzi S., Silvestro G., Rubino L., Tagliagambe A., Tonoli S., Valdagni R., Vavassori V., Vinciguerra A., Santoni, R, Arcangeli, S, Ingrosso, G, Antognoni, P, Mazzeo, E, D'Angelillo, R, Buglione, M, Borghesi, S, Petitti, T, Orecchia, R, Russi, E, Alitto, A, Alongi, F, Augurio, A, Bellavita, R, Bertoni, F, Bonetta, A, Bruni, A, Cagna, E, Cazzaniga, L, Corvo, R, D'Agostino, G, D'Amico, R, Detti, B, De Renzi, F, Fabrini, M, Fersino, S, Frascino, V, Gambarini, S, Genovesi, D, Grazioli, L, Guarneri, A, Jereczek-Fossa, B, Lancia, A, Livi, L, Magrini, S, Mantini, G, Mignogna, M, Mirri, M, Palumbo, I, Pergolizzi, S, Silvestro, G, Rubino, L, Tagliagambe, A, Tonoli, S, Valdagni, R, Vavassori, V, and Vinciguerra, A

Subjects
Leuprorelin, Gnrh Agonist, Gonadotropin-Releasing Hormone
Published
2016

48. 47. Dependence from dose and fractionation of late severe urinary toxicities after radical radiotherapy for prostate cancer

Author

Palorini, F., primary, Cicchetti, A., additional, Rancati, T., additional, Cozzarini, C., additional, Avuzzi, B., additional, Botti, A., additional, Cante, D., additional, Borca, V. Casanova, additional, Esposti, C. Degli, additional, Garibaldi, E., additional, Girelli, G., additional, Iotti, C., additional, Maggio, A., additional, Munoz, F., additional, Palombarini, M., additional, Pierelli, A., additional, Pignoli, E., additional, Vavassori, V., additional, Valdagni, R., additional, and Fiorino, C., additional

Published
2018
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49. 44. Metamodelling of late rectal bleeding in patients undergoing radiotherapy for prostate cancer

Author

Cicchetti, A., primary, Rancati, T., additional, Palorini, F., additional, Avuzzi, B., additional, Stucchi, C., additional, Vavassori, V., additional, Fellin, G., additional, Gabriele, P., additional, Degli Esposti, C., additional, Ebert, M., additional, Kennedy, A., additional, Joseph, D.J., additional, Denham, J.W., additional, Cozzarini, C., additional, Fiorino, C., additional, and Valdagni, R., additional

Published
2018
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50. PV-0320: NTCP models of late severe urinary symptoms after radical IMRT for prostate cancer

Author

Palorini, F., primary, Cicchetti, A., additional, Rancati, T., additional, Cozzarini, C., additional, Avuzzi, B., additional, Botti, A., additional, Cante, D., additional, Casanova Borca, V., additional, Degli Esposti, C., additional, Garibaldi, E., additional, Girelli, G., additional, Iotti, C., additional, Maggio, A., additional, Munoz, F., additional, Palombarini, M., additional, Pierelli, A., additional, Pignoli, E., additional, Vavassori, V., additional, Valdagni, R., additional, and Fiorino, C., additional

Published
2018
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