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309 results on '"Vauloup-Fellous C"'

15. Cost‐effectiveness of screening and valaciclovir‐based treatment strategies for first‐trimester cytomegalovirus primary infection in pregnant women in France

Author

Périllaud‐Dubois, C., primary, Hachicha‐Maalej, N., additional, Lepers, C., additional, Letamendia, E., additional, Teissier, N., additional, Cousien, A., additional, Sibiude, J., additional, Deuffic‐Burban, S., additional, Vauloup‐Fellous, C., additional, and Picone, O., additional

Published
2023
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31. Universal newborn screening for congenital cytomegalovirus infection: feasibility and relevance in a French type-III maternity cohort.

Author

Letamendia‐Richard, E, Périllaud‐Dubois, C, de La Guillonnière, L, Thouard, I, Cordier, A‐G, Roque‐Afonso, A‐M, de Luca, D, Benachi, A, Vauloup‐Fellous, C, Letamendia-Richard, E, Périllaud-Dubois, C, Cordier, A-G, Roque-Afonso, A-M, and Vauloup-Fellous, C

Subjects
CYTOMEGALOVIRUS diseases, CONGENITAL disorders, NEWBORN screening, CONGENITAL hypothyroidism, MEDICAL personnel, INFECTION, CYTOMEGALOVIRUS disease prevention, CYTOMEGALOVIRUS disease diagnosis, CYTOMEGALOVIRUSES, PILOT projects, PREDICTIVE tests, SALIVA, RETROSPECTIVE studies, QUESTIONNAIRES, PRENATAL care, RECEIVER operating characteristic curves, LONGITUDINAL method
Abstract

Objective: Evaluation of relevance and feasibility of universal newborn congenital cytomegalovirus infection (cCMVI) screening in saliva.Design: Retrospective, population-based cohort study.Setting: Clamart, France, 2016-2020.Population: All neonates born consecutively in our level III maternity unit.Methods: CMV PCR in saliva for all neonates at birth, and, if positive, CMV PCR in urine to confirm or exclude cCMVI. Prospective and retrospective characterisation of maternal infections. ROC curve analysis to assess saliva PCR performances. Acceptability of screening among staff members evaluated by a survey.Main Outcome Measures: Number of cCMVI neonates; number of expected and unexpected cCMVI.Results: Among 15 341 tested neonates, 63 had cCMVI (birth prevalence of 0.4%, 95% CI 0.3-0.5). In 50% of cases, maternal infection was a non-primary infection (NPI) during pregnancy. cCMVI was expected or suspected (maternal primary infection [PI], antenatal or neonatal signs) in 24/63 neonates (38%), and unexpected in 39/63 neonates (62%). The best CMV saliva threshold to predict cCMVI was 356 (2.55 log) copies/ml [95% CI 2.52 log-3.18 log], with an area under the ROC curve of 0.97. Over 90% of the 72 surveyed staff members reported that the screening was easy and quick. No parent refused the screening.Conclusions: Universal screening for cCMVI with CMV PCR on saliva samples is feasible and highly acceptable to parents and healthcare providers. Over half (62%) of the cases had no prenatal/neonatal signs of cCMVI or a maternal history of CMV infection during pregnancy and would probably not have been diagnosed without universal screening.Tweetable Abstract: In 62% of congenital cytomegalovirus infection cases, only universal neonatal screening in saliva can detect infection. [ABSTRACT FROM AUTHOR]

Published
2022
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33. Le traitement par rituximab diminue la réponse humorale, mais pas la réponse cellulaire, après vaccination anti-SARS-CoV-2 chez des patients atteints de maladie auto-immune

Author

Bitoun, S., primary, Henry, J., additional, Vauloup Fellous, C., additional, Joly, C., additional, Desjardins, D., additional, Bitu, M., additional, Seror, R., additional, Mouna, L., additional, Le Grand, R., additional, Roque Afonso, A.M., additional, and Mariette, X., additional

Published
2021
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39. Cytomégalovirus et grossesse

Author

Ami, O., primary, Vauloup-Fellous, C., additional, Mas, A.-E., additional, de Laveau-Coupet, J., additional, Grangeot-Keros, L., additional, and Picone, O., additional

Published
2011
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