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1. Author Correction: Visual field loss and vision-related quality of life in the Italian Primary Open Angle Glaucoma Study

Author

Rulli, Eliana, Quaranta, Luciano, Riva, Ivano, Poli, Davide, Hollander, Lital, Galli, Fabio, Katsanos, Andreas, Oddone, Francesco, Torri, Valter, Weinreb, N Varano L, Robert, Carchedi, T, Talarico, S, Frezzotti, P, Parravano, F, Motolese, I, Bagaglia, Sa, Rossi, Gcm, Lateri, S, Bossolesi, L, Carmassi, L, Rolle, T, Piccini, R, Ratiglia, R, Rossi, A, Gandolfi, S, Tagliavini, V, Ungaro, N, Fossarello, M, Cucca, A, Zucca, I, Uva, M, Bonacci, E, Cardarella, G, Tognetto, D, Vattovani, O, Vallon, P, Iannacone, F, Fontana, L, Marchi, S, Manni, Gl, Jannetta, D, Roberti, G, Rossetti, L, Maggiolo, E, Oneta, O, Sborgia, C, Cantatore, F, Mastropasqua, L, Agnifili, L, Campos, E, Gizzi, C, Giannaccare, G, Pucci, V, Cassamali, M, Costagliola, C, Traverso, C, Scotto, R, Musolino, M, Landi, L, Bagnis, A., Rulli, Eliana, Quaranta, Luciano, Riva, Ivano, Poli, Davide, Hollander, Lital, Galli, Fabio, Katsanos, Andrea, Oddone, Francesco, Torri, Valter, Weinreb, Robert, N Varano L, Carchedi, T, Talarico, S, Frezzotti, P, Parravano, F, Motolese, I, Bagaglia, Sa, Rossi, Gcm, Lateri, S, Bossolesi, L, Carmassi, L, Rolle, T, Piccini, R, Ratiglia, R, Rossi, A, Gandolfi, S, Tagliavini, V, Ungaro, N, Fossarello, M, Cucca, A, Zucca, I, Uva, M, Bonacci, E, Cardarella, G, Tognetto, D, Vattovani, O, Vallon, P, Iannacone, F, Fontana, L, Marchi, S, Manni, Gl, Jannetta, D, Roberti, G, Rossetti, L, Maggiolo, E, Oneta, O, Sborgia, C, Cantatore, F, Mastropasqua, L, Agnifili, L, Campos, E, Gizzi, C, Giannaccare, G, Pucci, V, Cassamali, M, Costagliola, C, Traverso, C, Scotto, R, Musolino, M, Landi, L, and Bagnis, A.

Subjects
Multidisciplinary, Open angle glaucoma, business.industry, Published Erratum, lcsh:R, MEDLINE, lcsh:Medicine, Italian Study Group on QoL in Glaucoma, Eye, Quality of life (healthcare), Medicine, Optometry, lcsh:Q, Visual field loss, business, lcsh:Science
Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2020

2. Vision-related quality of life and symptom perception change over time in newly-diagnosed primary open angle glaucoma patients

Author

Riva, I, Legramandi, L, Rulli, E, Konstas, Ag, Katsanos, A, Oddone, F, Weinreb, Rn, Quaranta, L, Varano, L, Carchedi, T, Talarico, S, Parravano, F, Motolese, I, Bagaglia, Sa, Rossi, Gcm, Lateri, S, Bossolesi, L, Carmassi, L, Rolle, T, Piccini, R, Ratiglia, R, Rossi, A, Gandolfi, S, Tagliavini, Ungaro, N, Fossarello, M, Cuccu, A, Zucca, I, Uva, M, Bonacci, E, Cardarella, G, Tognetto, D, Vattovani, O, Vallon, P, Iannacone, F, Fontana, L, Marchi, S, Manni, G, Iannetta, D, Roberti, G, Rossetti, L, Maggiolo, E, Oneta, O, Sborgia, C, Cantatore, F, Mastropasqua, L, Agnifili, L, Campos, E, Gizzi, C, Giannaccare, G, Pucci, Cassamali, M, Costagliola, C, Traverso, C, Scotto, R, Musolino, M, Landi, L, Bagnis, A, Riva I, Legramandi L, Rulli E, Konstas AG, Katsanos A, Oddone F, Weinreb RN, Quaranta L, Italian Study Group on QoL in Glaucoma: L Varano, T Carchedi, S Talarico, F Parravano, I Motolese, SA Bagaglia, GCM Rossi, S Lateri, L Bossolesi, L Carmassi, T Rolle, R Piccini, R Ratiglia, A Rossi, S Gandolfi, V Tagliavini, N Ungaro, M Fossarello, A Cuccu, I Zucca, M Uva, E Bonacci, G Cardarella, D Tognetto, O Vattovani, P Vallon, F Iannacone, L Fontana, S Marchi, GL Manni, D Jannetta, G Roberti, L Rossetti, E Maggiolo, O Oneta, C Sborgia, F Cantatore, L Mastropasqua, L Agnifili, E Campos, C Gizzi, G Giannaccare, V Pucci, M Cassamali, C Costagliola, C Traverso, R Scotto, M Musolino, L Landi, A Bagnis, Riva, Ivano, Legramandi, Lorenzo, Rulli, Eliana, Konstas, Anastasios G, Katsanos, Andrea, Oddone, Francesco, Weinreb, Robert N, Quaranta, Luciano, Varano, L, Carchedi, T, Talarico, S, Parravano, F, Motolese, I, Bagaglia, Sa, Rossi, Gcm, Lateri, S, Bossolesi, L, Carmassi, L, Rolle, T, Piccini, R, Ratiglia, R, Rossi, A, Gandolfi, S, Tagliavini, Ungaro, N, Fossarello, M, Cuccu, A, Zucca, I, Uva, M, Bonacci, E, Cardarella, G, Tognetto, D, Vattovani, O, Vallon, P, Iannacone, F, Fontana, L, Marchi, S, Manni, Gl, Jannetta, D, Roberti, G, Rossetti, L, Maggiolo, E, Oneta, O, Sborgia, C, Cantatore, F, Mastropasqua, L, Agnifili, L, Campos, E, Gizzi, C, Giannaccare, G, Pucci, Cassamali, M, Costagliola, C, Traverso, C, Scotto, R, Musolino, M, Landi, L, and Bagnis, A.

Subjects
0301 basic medicine, Change over time, medicine.medical_specialty, Aging, Visual acuity, Open angle glaucoma, genetic structures, Population, lcsh:Medicine, Glaucoma, Diseases, Italian Study Group on QoL in Glaucoma, Neurodegenerative, Eye, Article, 03 medical and health sciences, Medical research, 0302 clinical medicine, Quality of life, Clinical Research, Settore MED/30, Internal medicine, medicine, POAG, lcsh:Science, education, Prospective cohort study, Author Correction, Eye Disease and Disorders of Vision, education.field_of_study, Multidisciplinary, business.industry, lcsh:R, Neurosciences, medicine.disease, primary open angle glaucoma, humanities, eye diseases, 030104 developmental biology, Symptom perception, glaucoma, quality of life, lcsh:Q, sense organs, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

To evaluate the change over time of vision-related quality of life (QoL) and glaucoma symptoms in a population of newly-diagnosed primary open angle glaucoma (POAG) patients. Multicenter, prospective study. Consecutive newly-diagnosed POAG patients were enrolled and followed-up for one year. Follow-up visits were scheduled at 6 and 12 months from baseline. At each visit, vision-related QoL and glaucoma-related symptoms were assessed by the means of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and the Glaucoma Symptom Scale (GSS), respectively. Trends over time for NEI-VFQ-25 and GSS scores were evaluated with longitudinal linear mixed models. One-hundred seventy-eight patients were included in the analysis. At baseline, early to moderate glaucoma stages were associated with higher scores for most GSS and NEI-VFQ-25 items, while lower best-corrected visual acuity was associated with lower scores for 4 of the 12 NEI-VFQ-25 items. During the follow-up, all the GSS scores, the NEI-VFQ-25 total score, and 7 of the 12 NEI-VFQ-25 scores significantly improved (p

Published
2019

3. Author Correction: Vision-related quality of life and symptom perception change over time in newly-diagnosed primary open angle glaucoma patients (Scientific Reports, (2019), 9, 1, (6735), 10.1038/s41598-019-43203-9)

Author

Riva, I., Legramandi, L., Rulli, E., Konstas, A. G., Katsanos, A., Oddone, F., Weinreb, R. N., Quaranta, L., Varano, L., Carchedi, T., Talarico, S., Frezzotti, P., Parravano, F., Motolese, I., Bagaglia, S. A., Rossi, G. C. M., Lateri, S., Bossolesi, L., Carmassi, L., Rolle, T., Piccini, R., Ratiglia, R., Rossi, A., Gandolfi, S., Tagliavini, V., Ungaro, N., Fossarello, M., Cuccu, A., Zucca, I., Uva, M., Bonacci, E., Cardarella, G., Tognetto, D., Vattovani, O., Vallon, P., Iannacone, F., Fontana, L., Marchi, S., Manni, G. L., Jannetta, D., Roberti, G., Rossetti, L., Maggiolo, E., Oneta, O., Sborgia, C., Cantatore, F., Mastropasqua, L., Agnifili, L., Campos, E., Gizzi, C., Giannaccare, G., Pucci, V., Cassamali, M., Costagliola, C., Traverso, C., Scotto, R., Musolino, M., Landi, L., and Bagnis, A.

Subjects
Settore MED/30
Published
2020

4. Author Correction: Visual field loss and vision-related quality of life in the Italian Primary Open Angle Glaucoma Study (Scientific Reports, (2018), 8, 1, (619), 10.1038/s41598-017-19113-z)

Author

Rulli, E., Quaranta, L., Riva, I., Poli, D., Hollander, L., Galli, F., Katsanos, A., Oddone, F., Torri, V., Weinreb, R. N., Varano, L., Carchedi, T., Talarico, S., Frezzotti, P., Parravano, F., Motolese, I., Bagaglia, S. A., Rossi, G. C. M., Lateri, S., Bossolesi, L., Carmassi, L., Rolle, T., Piccini, R., Ratiglia, R., Rossi, A., Gandolfi, S., Tagliavini, V., Ungaro, N., Fossarello, M., Cucca, A., Zucca, I., Uva, M., Bonacci, E., Cardarella, G., Tognetto, D., Vattovani, O., Vallon, P., Iannacone, F., Fontana, L., Marchi, S., Manni, G. L., Jannetta, D., Roberti, G., Rossetti, L., Maggiolo, E., Oneta, O., Sborgia, C., Cantatore, F., Mastropasqua, L., Agnifili, L., Campos, E., Gizzi, C., Giannaccare, G., Pucci, V., Cassamali, M., Costagliola, C., Traverso, C., Scotto, R., Musolino, M., Landi, L., and Bagnis, A.

Subjects
Settore MED/30
Published
2020

5. Influence of Sociodemographic Factors on Disease Characteristics and Vision-related Quality of Life in Primary Open-angle Glaucoma Patients: The Italian Primary Open Angle Glaucoma Study (IPOAGS)

Author

Riva, Ivano, Legramandi, Lorenzo, Katsanos, Andreas, Oddone, Francesco, Rulli, Eliana, Roberti, Gloria, Quaranta Luciano, Varano L, Carchedi T, Talarico S, Parravano F, Motolese I, Bagaglia SA, Rossi GCM, Lateri S, Bossolesi L, Carmassi L, Rolle T, Piccini R, Ratiglia R, Rossi A, Gandolfi S, Tagliavini V, Ungaro N, Fossarello M, Cucca A, Zucca I, Uva M, Bonacci E, Cardarella G, Tognetto D, Vattovani O, Vallon P, Iannacone F, Fontana L, Marchi S, Manni GL, Jannetta D, Roberti G, Rossetti L, Maggiolo E, Oneta O, Sborgia C, Cantatore F, Mastropasqua L, Agnifili L, Campos E, Gizzi C, Giannaccare G, Pucci V, Cassamali M, Costagliola C, Scotto R, Musolino M, Landi L, Bagnis A., I Riva, L Legramandi, A Katsanos, F Oddone, E Rulli, G Roberti, L Quaranta, Italian Study Group on QoL in Glaucoma: L Varano, T Carchedi, S Talarico, F Parravano, I Motolese, SA Bagaglia, GCM Rossi, S Lateri, L Bossolesi, L Carmassi, T Rolle, R Piccini, R Ratiglia, A Rossi, S Gandolfi, V Tagliavini, N Ungaro, M Fossarello, A Cucca, I Zucca, M Uva, E Bonacci, G Cardarella, D Tognetto, O Vattovani, P Vallon, F Iannacone, L Fontana, S Marchi, GL Manni, D Jannetta, L Rossetti, E Maggiolo, O Oneta, C Sborgia, F Cantatore, L Mastropasqua, L Agnifili, E Campos, C Gizzi, G Giannaccare, V Pucci, M Cassamali, C Costagliola, C Traverso, R Scotto, M Musolino, L Landi, A Bagnis, Riva, Ivano, Legramandi, Lorenzo, Katsanos, Andrea, Oddone, Francesco, Rulli, Eliana, Roberti, Gloria, Quaranta, Luciano, Varano, L, Carchedi, T, Talarico, S, Parravano, F, Motolese, I, Bagaglia, Sa, Rossi, Gcm, Lateri, S, Bossolesi, L, Carmassi, L, Rolle, T, Piccini, R, Ratiglia, R, Rossi, A, Gandolfi, S, Tagliavini, V, Ungaro, N, Fossarello, M, Cucca, A, Zucca, I, Uva, M, Bonacci, E, Cardarella, G, Tognetto, D, Vattovani, O, Vallon, P, Iannacone, F, Fontana, L, Marchi, S, Manni, Gl, Jannetta, D, Roberti, G, Rossetti, L, Maggiolo, E, Oneta, O, Sborgia, C, Cantatore, F, Mastropasqua, L, Agnifili, L, Campos, E, Gizzi, C, Giannaccare, G, Pucci, V, Cassamali, M, Costagliola, C, Scotto, R, Musolino, M, Landi, L, and Bagnis, A.

Subjects
Male, medicine.medical_specialty, Multivariate statistics, Visual acuity, Open angle glaucoma, genetic structures, Cross-sectional study, sociodemographic factors, Visual Acuity, Glaucoma, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Internal medicine, Settore MED/30, Sickness Impact Profile, Surveys and Questionnaires, medicine, Humans, 030212 general & internal medicine, Intraocular Pressure, Vision, Ocular, Aged, Demography, business.industry, Middle Aged, medicine.disease, eye diseases, glaucoma, quality of life, Ophthalmology, Cross-Sectional Studies, Italy, sociodemographic factor, 030221 ophthalmology & optometry, Quality of Life, Marital status, Disease characteristics, Female, medicine.symptom, business, Glaucoma, Open-Angle
Abstract

Purpose: The purpose of this article was to evaluate the potential association between sociodemographic factors with clinical characteristics, vision-related quality of life (QoL), and glaucoma-related symptoms scores in a large cohort of primary open-angle glaucoma patients. Materials and Methods: Multicenter, cross-sectional study involving academic and nonacademic centers. Previously diagnosed primary open-angle glaucoma patients aged >18 years were enrolled. At baseline, information on demographic characteristics, social, medical and ocular history, clinical presentation and treatments was collected. Vision-related QoL was evaluated by means of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25), while glaucoma-related symptoms were evaluated using the Glaucoma Symptom Scale (GSS) questionnaire. The associations between sociodemographic factors with clinical characteristics (mean deviation, pattern standard deviation, best-corrected visual acuity), NEI-VFQ-25, and GSS scores were evaluated by means of univariate and multivariate general linear models. Results: A total of 3227 patients were enrolled. Older age and male sex were significantly associated with lower mean deviation (P

Published
2018

7. Health-related quality of life in patients with primary open-angle glaucoma. An Italian multicentre observational study

Author

Floriani, I., Quaranta, L., Rulli, E., Katsanos, A., Varano, L., Frezzotti, P., Rossi G. C., M., Carmassi, L., Rolle, T., Ratiglia, R., Gandolfi, S., Fossarello, M., Uva, BIANCA MARIA, Hollander, L., Poli, D., Grignolo, F., Roberto, A., Clivio, L., Galli, F., Carlucci, L., Riva, I., Delcassi, L., Carchedi, T., Talarico, S., Motolese, I., Bagaglia S., A., Lanteri, Silvia, Bossolesi, L., Piccini, R., Rossi, A., Tagliavini, V., Ungaro, N., Cuccu, A., Zucca, I., Bonacci, E., Cardarella, G., Tognetto, D., Vattovani, O., Vallon, P., Iannacone, F., Fontana, L., Marchi, S., Manni G., L., Jannetta, D., Roberti, G., Rossetti, L., Maggiolo, E., Oneta, O., Sborgia, C., Cantatore, F., Mastropasqua, L., Agnifili, L., Campos, E., Gizzi, C., Giannaccare, G., Pucci, V., Cassamali, M., Costagliola, C., Traverso, Carlo, Scotto, Riccardo, Musolino, Maria, Landi, L., and Bagnis, A.

Published
2016

13. Macular function after laser treatment of soft drusen

Author

Saviano S, Battaglia Parodi M, Iustulin D, Vattovani O, Rinaldi G, Saviano S, Capone A, De Juan E, Del Priore L, Panozzo G, Zarbin MA, Saviano, S, Battaglia Parodi, M, Iustulin, D, Vattovani, O, and Rinaldi, G

Published
1998

15. Vascular risk factors in glaucoma: the results of a national survey

Author

Orzalesi, N., Rossetti, L., Omboni, S., OPTIME study group, Sborgia, C, Vetrugno, M, Cantatore, F, Campos, E, Baldi, A, Quaranta, Luciano, University of Cagliari, University of Catania Uva, M, Longo, A, Lombardo, A, Scorcia, G, Moschettini, R, Gallenga, Pe, Mastropasqua, L, Ciancaglini, M, Carpineto, P, Lobefalo, L, University of Ferrara, University of Firenze (Alfieri, G, Menchini, U, Campana, F, Giansanti, F, Delle Noci, N, Balducci, F, Calabria, G, Saccà, S, Sanna, G, Camicione, P, Mastromarino, A, Balestrazzi, E, Di Staso, S, Ferreri, G, D’Andrea, A, Orzalesi, N, Rossetti, L, Fogagnolo, P, Mazzolani, F, Brancato, R, Carassa, R, Bettin, P, Fiori, M, Guerra, R, Martini, E, Scarale, G, Campi, L, Bonavolontà, G, Rinaldi, E, Di Meo, A, Fusco, R, Dorigo, Mt, Doro, D, Grgic, V, Lodato, G, Morreale Bubella, D, Signorelli, F, Gandolfi, S, Trimarchi, F, Milano, G, Fiore, C, De Carolis, A, Sbordone, G, Nardi, M, Bartolomei, Mp, Figus, M, Guidi, G, Scullica, L, Salgarello, T, Colotto, A, Bucci, Mg, Cerulli, L, Manni, Gl, Centofanti, M, Parravano, M, Scuderi, G, Nucci, C, Carta, F, Pinna, A, Caporossi, A, Frezzotti, P, Grignolo, F, Brogliatti, B, Rolle, T, Ravalico, G, Vattovani, O, Tritto, D, Canziani, T, Marchini, G, and Marraffa, M.

Subjects
glaucoma, genetic structures, risk factors, sense organs, eye diseases
Published
2007

24. Observer interpretation variability of peripapillary flow using the Heidelberg Retina Flowmeter.

Author

Iester, M., Ciancaglini, M., Rolle, T., and Vattovani, O.

Subjects
RETINAL blood vessels, BLOOD flow, FLOW meters, DOPPLER effect, OPTIC disc, GLAUCOMA, INTRAOCULAR pressure
Abstract

PurposeTo evaluate the intraobserver and interobserver reproducibility of the automatic full field perfusion image analysis (AFFPIA) program on Heidelberg Retina Flowmeter (HRF) derived perfusion images in a multicentre study group.MethodsA total of 10 subjects were consecutively recruited in the study. One eye was randomly selected for each patient. Blood flow was assessed by HRF and flow measurements were analyzed by using the AFFPIA program. AFFPIA calculates the Doppler frequency shift and the haemodynamic variables: flow for each pixel. Intraobserver and interobserver reproducibility was calculated for AFFPIA program. The retinal blood flow was calculated in the superior and inferior section, furthermore, each section was divided into three parts: the temporal area, the nasal, and the rim area, as for software, but only the temporal and nasal areas were considered in this study. The blood flow and the area considered were evaluated for each part.ResultsWhen the intraobserver and intraimage reproducibility was studied, the coefficient of variation ranged from 0.4 to 1.9%. When the interobserver and intraimage reproducibility was studied, the retinal blood flow coefficient of variation ranged from 0.52 to 3.30% for the supero-temporal area, from 0.13 to 2.67% for the inferotemporal area, from 0.15 to 2.75% for the supero-nasal area, and from 0.04 to 5.65% for the infero-nasal area.ConclusionOur results with AFFPIA showed an interobserver coefficient of variation of retinal blood flow measurements always less than 6% in both temporal and nasal areas. No significant difference was found among the four observers for the flow measurements.Eye (2006) 20, 1246–1253. doi:10.1038/sj.eye.6702086; published online 28 October 2005 [ABSTRACT FROM AUTHOR]

Published
2006
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25. Atypical pattern of retardation on GDx-VCC and its effect on retinal nerve fibre layer evaluation in glaucomatous eyes.

Author

Da Pozzo, S., Marchesan, R., Canziani, T., Vattovani, O., and Ravalico, G.

Subjects
GLAUCOMA diagnosis, RETINA, NERVES, POLARIMETRY, SCANNING laser ophthalmoscopy, OPTICAL measurements
Abstract

PurposeTo assess the effect of atypical pattern of retardation (APR) on retinal nerve fibre layer (RNFL) measurements made by scanning laser polarimetry (SLP) with variable corneal compensation (GDx-VCC) in glaucomatous eyes.MethodsOne eye each of 30 glaucomatous patients (average mean deviation (MD): −6.4±4.8) with APR on GDx-VCC retardation map were selected. In total, 34 glaucomatous, age- and severity-matched eyes (average MD: −7.0±5.3) and 36 age-matched healthy subjects, both with a normal pattern of retardation (NPR) represented control groups. APR on retardation maps was characterized by alternating peripapillary circumferential bands of low and high retardation, or high retardation areas arranged in a spokelike pattern, or high retardation nasal and temporal splotchy areas. Typical scan score (TSS) was extracted for each included eye. GDx-VCC parameters (mean±SD) in the two groups of glaucomatous eyes were compared with healthy eyes' corresponding values (Mann–Whitney U-test). Areas under receiver operating characteristic (AUROC) curves were generated to assess the APR effect on the parameters' diagnostic ability.ResultsAll parameters discriminated adequately between healthy and glaucomatous eyes with NPR (AUROCs ≥0.9 for nine parameters). On the contrary, considering healthy and glaucomatous eyes with APR, four thickness parameters could not separate the two groups and AUROCs ≥0.85 appeared only for Inferior and Superior Ratio, NFI, Max Modulation.ConclusionAPR may void the effect of custom compensation and provide spurious RNFL thickness measurements. When a printout of glaucomatous eyes with APR is evaluated, it is proper to rely on ratios, modulation parameters, and NFI, since the diagnostic ability of thickness parameters is significantly reduced.Eye (2006) 20, 769–775. doi:10.1038/sj.eye.6701997; published online 8 July 2005 [ABSTRACT FROM AUTHOR]

Published
2006
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26. Visual field loss and vision-related quality of life in the Italian Primary Open Angle Glaucoma Study

Author

Davide Poli, Eliana Rulli, Luigi Varano, S. Talarico, S. Lateri, Luca Agnifili, C. Gizzi, F. Parravano, Teresa Rolle, E. Maggiolo, P. Vallon, Ilaria Motolese, Andreas Katsanos, S. Marchi, E. Bonacci, O. Vattovani, Luciano Quaranta, V. Pucci, L. Fontana, Francesco Oddone, Lorenza Landi, Luciana Carmassi, Ivano Riva, D. Jannetta, F. Cantatore, A. Bagnis, Carlo Enrico Traverso, Ciro Costagliola, O. Oneta, L. Bossolesi, Ignazio Alberto Zucca, Emilio C. Campos, Giulio Mirabella Roberti, Luca Rossetti, N. Ungaro, V. Tagliavini, A. Cucca, Michele Uva, D. Tognetto, Carlo Sborgia, Roberto Ratiglia, Stefano A. Gandolfi, Giuseppe Giannaccare, Maurizio Fossarello, R. Piccini, Lital Hollander, Gianluca Manni, M. Cassamali, F. Iannacone, R. Scotto, Robert N. Weinreb, M. Musolino, A. Rossi, L. Mastropasqua, T. Carchedi, Valter Torri, Simone Alex Bagaglia, F. Galli, G. Cardarella, Gemma Caterina Maria Rossi, Rulli, E., Quaranta, L., Riva, I., Poli, D., Hollander, L., Galli, F., Katsanos, A., Oddone, F., Torri, V., Weinreb, R. N., Varano, L., Carchedi, T., Talarico, S., Parravano, F., Motolese, I., Bagaglia, S. A., Rossi, G. C. M., Lateri, S., Bossolesi, L., Carmassi, L., Rolle, T., Piccini, R., Ratiglia, R., Rossi, A., Gandolfi, S., Tagliavini, V., Ungaro, N., Fossarello, M., Cucca, A., Zucca, I., Uva, M., Bonacci, E., Cardarella, G., Tognetto, D., Vattovani, O., Vallon, P., Iannacone, F., Fontana, L., Marchi, S., Manni, G. L., Jannetta, D., Roberti, G., Rossetti, L., Maggiolo, E., Oneta, O., Sborgia, C., Cantatore, F., Mastropasqua, L., Agnifili, L., Campos, E., Gizzi, C., Giannaccare, G., Pucci, V., Cassamali, M., Costagliola, C., Traverso, C., Scotto, R., Musolino, M., Landi, L., Bagnis, A., Rulli, Eliana, Quaranta, Luciano, Riva, Ivano, Poli, Davide, Hollander, Lital, Galli, Fabio, Katsanos, Andrea, Oddone, Francesco, Torri, Valter, Weinreb, Robert N., Fontana, Luigi, Marchi, Susanna, Bagaglia, S.A., Rossi, G.C.M., and Manni, G.L.

Subjects
Male, Aging, Visual acuity, genetic structures, lcsh:Medicine, Glaucoma, Neurodegenerative, Eye, 0302 clinical medicine, Quality of life, Visual Field Test, Surveys and Questionnaires, 80 and over, Surveys and Questionnaire, Young adult, lcsh:Science, Aged, 80 and over, Multidisciplinary, Middle Aged, Visual field, Open-Angle, Italy, Female, Visual field loss, medicine.symptom, Glaucoma, Open-Angle, Human, Adult, medicine.medical_specialty, glaucoma, quality of life, Visual field, Open angle glaucoma, Vision Disorders, Italian Study Group on QoL in Glaucoma, and over, Article, 03 medical and health sciences, Young Adult, Clinical Research, Ophthalmology, Settore MED/30, medicine, Humans, Author Correction, Eye Disease and Disorders of Vision, Aged, business.industry, lcsh:R, Vision Disorder, Neurosciences, medicine.disease, eye diseases, Quality of Life, Visual Field Tests, Clinical trial, glaucoma, quality of life, 030221 ophthalmology & optometry, lcsh:Q, business, 030217 neurology & neurosurgery
Abstract

The aim of this study was to examine the relationship between visual field (VF) loss, vision-related quality of life (QoL) and glaucoma-related symptoms in a large cohort of primary open angle glaucoma (POAG) patients. POAG patients with or without VF defects or “glaucoma suspect” patients were considered eligible. QoL was assessed using the validated versions of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and glaucoma-related symptoms were assessed using the Glaucoma Symptom Scale (GSS). Patients were classified as having VF damage in one eye (VFD-1), both eyes (VFD-2), or neither eye (VFD-0). 3227 patients were enrolled and 2940 were eligible for the analysis. 13.4% of patients were classified in the VFD-0, 23.7% in the VFD-1, and 62.9% in the VFD-2 group. GSS visual symptoms domain (Func-4) and GSS non-visual symptoms domain (Symp-6) scores were similar for the VFD-0 and VFD-1 groups (p = 0.133 and p = 0.834 for Func-4 and Symp-6, respectively). VFD-0 group had higher scores than VFD-2 both in Func-4 (p

Published
2018

27. Atypical pattern of retardation on GDx-VCC and its effect on retinal nerve fibre layer evaluation in glaucomatous eyes

Author

T. Canziani, Roberta Marchesan, Giuseppe Ravalico, S. Da Pozzo, Odilla Vattovani, DA POZZO, S, Marchesan, R, Canziani, T, Vattovani, O, and Ravalico, Giuseppe

Subjects
Male, Retinal Ganglion Cells, medicine.medical_specialty, genetic structures, Eye disease, Glaucoma, Scanning laser polarimetry, Nerve fiber, Diagnostic Techniques, Ophthalmological, Severity of Illness Index, chemistry.chemical_compound, Nerve Fibers, Ophthalmology, Optic Nerve Diseases, medicine, Humans, Aged, Retrospective Studies, Retina, Balayage, Receiver operating characteristic, business.industry, Retinal, medicine.disease, eye diseases, medicine.anatomical_structure, ROC Curve, chemistry, Disease Progression, Female, sense organs, Visual Fields, business
Abstract

To assess the effect of atypical pattern of retardation (APR) on retinal nerve fibre layer (RNFL) measurements made by scanning laser polarimetry (SLP) with variable corneal compensation (GDx-VCC) in glaucomatous eyes.One eye each of 30 glaucomatous patients (average mean deviation (MD): -6.4+/-4.8) with APR on GDx-VCC retardation map were selected. In total, 34 glaucomatous, age- and severity-matched eyes (average MD: -7.0+/-5.3) and 36 age-matched healthy subjects, both with a normal pattern of retardation (NPR) represented control groups. APR on retardation maps was characterized by alternating peripapillary circumferential bands of low and high retardation, or high retardation areas arranged in a spokelike pattern, or high retardation nasal and temporal splotchy areas. Typical scan score (TSS) was extracted for each included eye. GDx-VCC parameters (mean+/-SD) in the two groups of glaucomatous eyes were compared with healthy eyes' corresponding values (Mann-Whitney U-test). Areas under receiver operating characteristic (AUROC) curves were generated to assess the APR effect on the parameters' diagnostic ability.All parameters discriminated adequately between healthy and glaucomatous eyes with NPR (AUROCsor =0.9 for nine parameters). On the contrary, considering healthy and glaucomatous eyes with APR, four thickness parameters could not separate the two groups and AUROCsor =0.85 appeared only for Inferior and Superior Ratio, NFI, Max Modulation.APR may void the effect of custom compensation and provide spurious RNFL thickness measurements. When a printout of glaucomatous eyes with APR is evaluated, it is proper to rely on ratios, modulation parameters, and NFI, since the diagnostic ability of thickness parameters is significantly reduced.

Published
2006

28. Comparing measurements of retinal nerve fiber layer thickness obtained on scanning laser polarimetry with fixed and variable corneal compensator

Author

S. Da Pozzo, Odilla Vattovani, Giuseppe Ravalico, Pierluigi Iacono, Roberta Marchesan, DA POZZO, S., Iacono, P., Marchesan, R., Vattovani, O., and Ravalico, Giuseppe

Subjects
Adult, Male, Retinal Ganglion Cells, medicine.medical_specialty, Materials science, genetic structures, Nerve fiber layer, Scanning laser polarimetry, Glaucoma, law.invention, Cornea, 03 medical and health sciences, chemistry.chemical_compound, Tonometry, Ocular, 0302 clinical medicine, Optics, Nerve Fibers, law, Ophthalmology, Linear regression, medicine, Humans, Intraocular Pressure, Aged, Aged, 80 and over, Birefringence, business.industry, Automated perimetry, Lasers, Retinal, General Medicine, Middle Aged, medicine.disease, eye diseases, medicine.anatomical_structure, chemistry, Achromatic lens, 030221 ophthalmology & optometry, Visual Field Tests, Female, sense organs, business, 030217 neurology & neurosurgery
Abstract

PurposeTo compare retinal nerve fiber layer (RNFL) thickness measurements obtained on scanning laser polarimetry (SLP) with commercially available instruments coupled with fixed (FCC) and variable corneal compensator (VCC).MethodsForty-two eyes of 42 patients underwent a complete ophthalmologic evaluation and achromatic automated perimetry (24-2 program, SITA standard strategy). Nineteen eyes were healthy (average mean deviation: -0.12 dB ± 2.26) and 23 glaucomatous (average mean deviation: -4.92 dB ± 6.49). All patients underwent SLP with both FCC and VCC. Adequate compensation of corneal birefringence on FCC-SLP was checked acquiring macular retardation map (MRM). RNFL thickness was evaluated considering superior and inferior maximum (SM, IM), average thickness and ellipse average (AT, EA), and superior and inferior average (SA, IA). Mean values (±SD) for each parameter measured by the two polarimeters were compared and linear regression calculated. The ability of each parameter to discriminate between normal and glaucomatous eyes was evaluated on both polarimeters calculating area under ROC curve.ResultsA significant linear correlation for all parameters was noted (r range: 0.65–0.78). VCC produced slightly higher thickness values than FCC, both in normal and glaucomatous eyes. On both polarimeters, area under ROC curve for all parameters discriminated adequately healthy from glaucomatous eyes (range: 0.68–0.81).ConclusionsIn a highly comparable and selected group of normal and glaucomatous eyes, FCC-SLP and VCC-SLP showed considerable concordance in measuring peripapillary RNFL thickness, both for sectorial and global parameters. Proper corneal birefringence compensation provided separation of normal from glaucomatous eyes on both polarimeters.

Published
2005

29. Retinal detachment after cataract extraction and refractive lens exchange in highly myopic patients

Author

Giuseppe Ravalico, Daniele Tognetto, Odilla Vattovani, Cinzia Michieli, Ravalico, Giuseppe, Michieli, C, Vattovani, O, and Tognetto, Daniele

Subjects
Adult, Male, medicine.medical_specialty, Refractive error, genetic structures, medicine.medical_treatment, Eye disease, Intraocular lens, Cataract Extraction, Light Coagulation, Refraction, Ocular, Vitreous Detachment, Cataract, Retina, medicine, Myopia, Humans, Dioptre, Aged, Retrospective Studies, Aged, 80 and over, Lenses, Intraocular, business.industry, Retinal Detachment, Retinal detachment, Phacoemulsification, Middle Aged, medicine.disease, Retinal Perforations, eye diseases, Sensory Systems, Surgery, Ophthalmology, Treatment Outcome, Capsulotomy, Female, sense organs, business, Retinopathy
Abstract

Purpose To assess the refractive effects and incidence of postoperative complications in patients with high myopia after cataract extraction. Setting University Eye Clinic, Trieste, Italy. Methods This noncomparative retrospective study comprised all eyes (N = 388) having cataract extraction and implantation of an intraocular lens with a power less than 11.0 diopters (D) between 1986 and 1999. The preoperative and postoperative refractions; preoperative, postoperative, and final best corrected visual acuity (BCVA); and postoperative complications were analyzed. The mean follow-up was 47.16 months ± 32.83 (SD) (range 8 to 146 months). Results Phacoemulsification was performed in 237 eyes, extracapsular cataract extraction in 147 eyes, and intracapsular cataract extraction in 4 eyes. The mean preoperative BCVA was 0.20 ± 0.21 and the mean postoperative BCVA, 0.58 ± 0.32. At the final evaluation, the mean BCVA was 0.50 ± 0.33. The mean refraction was −15.95 ± 5.86 D preoperatively and −2.00 ± 1.62 D postoperatively. One eye (0.26%) developed a retinal detachment postoperatively. Of the 127 eyes (32.73%) having a neodymium:YAG laser capsulotomy for posterior capsule opacification, 1 had a macular retinal hole. Posterior detachment of the vitreous occurred in 78.6% of cases. Peripheral retinal photocoagulation was required in 8 cases postoperatively. Conclusions Refractive lens exchange led to good functional results and a low incidence of postoperative complications and can thus be regarded as a viable technique to correct high myopia associated with cataract. However, further study is required before it can be routinely recommended for the correction of high myopia in eyes with a transparent crystalline lens.

Published
2003

30. Correlation between the Retinal Nerve Fiber Layer Thickness and the Pattern Electroretinogram Amplitude

Author

Giovanni Toffoli, Giuseppe Ravalico, Giulio Pastori, G. Rinaldi, Paolo Cecchini, Odilla Vattovani, Toffoli, G, Vattovani, O, Cecchini, P, Pastori, G, Rinaldi, G, and Ravalico, Giuseppe

Subjects
Adult, Male, Retinal Ganglion Cells, Materials science, Adolescent, genetic structures, Nerve fiber layer, Ocular hypertension, Nerve fiber, chemistry.chemical_compound, Nerve Fibers, Optics, Electroretinography, medicine, Humans, Aged, Retina, Balayage, medicine.diagnostic_test, business.industry, Lasers, Optic Nerve, Retinal, Polarimeter, General Medicine, Middle Aged, medicine.disease, eye diseases, Sensory Systems, Ophthalmology, medicine.anatomical_structure, chemistry, Visual Field Tests, Female, Ocular Hypertension, sense organs, business, Glaucoma, Open-Angle, Biomedical engineering
Abstract

Objective: To establish a correlation between the retinal nerve fiber layer (RNFL) thickness measured by a scanning laser polarimeter (GDx) and the pattern electroretinogram (p-ERG) amplitudes in a heterogeneous population sample composed of normal subjects, ocular hypertensive and glaucomatous patients. Methods: 112 subjects were considered: 40 glaucomatous patients, 39 ocular hypertensive and 33 normal subjects. All were examined with the GDx, and the RNFL thickness was measured. A transient p-ERG was then recorded. Results: A statistically significant correlation was observed between the RNFL thickness and the p-ERG amplitudes (p < 0.001) by means of linear regression analysis. Conclusion: We observed a strict correlation between the measurements of the RNFL thickness obtained with the GDx and the amplitude of the p-ERG signal. These techniques represent additional objective tools to detect an early glaucomatous damage.

Published
2002

31. Corneal endothelial function in diabetes: a fluorophotometric study

Author

Mariantonietta Palomba, Odilla Vattovani, Giuseppe Ravalico, Sergio Calderini, Daniele Tognetto, Ravalico, Giuseppe, Tognetto, Daniele, Palomba, M. A., Calderini, S., and Vattovani, O.

Subjects
medicine.medical_specialty, Corneal endothelium, Cell Membrane Permeability, Endothelium, Eye disease, Biological Transport, Active, Fluorophotometry, Cornea, chemistry.chemical_compound, fluorophotometric study, Internal medicine, Diabetes mellitus, medicine, Humans, Aged, Diabetic Retinopathy, diabetes, Anthropometry, business.industry, corneal endothelial, Endothelium, Corneal, Retinal, General Medicine, medicine.disease, eye diseases, Sensory Systems, Ophthalmology, Endocrinology, medicine.anatomical_structure, Diabetes Mellitus, Type 1, chemistry, Diabetes Mellitus, Type 2, diabete, sense organs, business, Retinopathy
Abstract

The corneal endothelium in diabetics is particularly susceptible to surgical trauma. This is related to the presence of morphological alterations of endothelial cells and to a supposedly concomitant functional failure of the endothelium in these patients. The aim of our study was to evaluate the corneal endothelial function in diabetics. A fluorophotometric study was performed on 3 groups of diabetic subjects without retinopathy, with nonproliferative retinopathy and with proliferative retinopathy compared with an age-matched control group. We evidenced a significant increase in corneal thickness and in passive corneal permeability in diabetics with severe retinal involvement. These findings are not related with a proportional significant increase in endothelial pump function. We suggest an altered regulation in corneal hydration in diabetic patients depending on the functional failure of endothelial cells that is likely to be connected with corneal biochemical modifications caused by an altered glucidic metabolism.

Published
1994

32. Fever and Vision Loss in an Immunocompetent 20-Year-Old Male.

Author

Di Bella S, Rinaldi S, Maurel C, Vattovani O, Luzzati R, and Tognetto D

Subjects
Adult, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents therapeutic use, Cat-Scratch Disease complications, Cat-Scratch Disease pathology, Doxycycline administration & dosage, Doxycycline therapeutic use, Fever, Humans, Lymphadenopathy, Male, Retinitis etiology, Retinitis pathology, Rifampin administration & dosage, Rifampin therapeutic use, Bartonella henselae drug effects, Cat-Scratch Disease diagnostic imaging, Cat-Scratch Disease drug therapy, Retinitis diagnostic imaging, Retinitis drug therapy
Published
2017
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33. Scanning Electron Microscopy Evaluation of an EX-PRESS Mini Glaucoma Shunt After Explantation.

Author

Tognetto D, Cecchini P, D'Aloisio R, Vattovani O, and Turco G

Subjects
Aged, Glaucoma, Open-Angle diagnosis, Glaucoma, Open-Angle physiopathology, Humans, Male, Prosthesis Failure, Anterior Chamber ultrastructure, Device Removal methods, Extracellular Matrix ultrastructure, Glaucoma Drainage Implants adverse effects, Glaucoma, Open-Angle surgery, Intraocular Pressure physiology, Microscopy, Electron, Scanning methods
Abstract

We report a case of an explanted stainless steel miniature glaucoma drainage device (EX-PRESS) implanted under a scleral flap for pseudoexfoliation open-angle glaucoma surgical treatment. The glaucoma shunt was implanted in a 75-year-old white man with medically refractive glaucoma. Cataract surgery was performed simultaneously. After 2 years, the shunt extruded through the scleral flap and the conjunctiva and it was, therefore, explanted. Scanning electron microscopy images of the EX-PRESS mini glaucoma shunt were acquired to verify the patency of the device lumen and the presence of fibrosis or cellular adhesion on the device. Energy dispersive spectroscopy for chemical surface characterization of the EX-PRESS shunt was performed. Scanning electron microscopy-acquired images showed minimal extracellular material proliferation on the lumen device. The energy dispersive spectroscopy analysis revealed a high peak of carbon suggesting the organic nature of the residuals found on the shunt lumen. The surface showed few superficial pits, likely due to an initial corrosion process.

Published
2017
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34. Unilateral Optic Neuritis: A Rare Complication after Measles-Mumps-Rubella Vaccination in a 30-Year-Old Woman.

Author

De Giacinto C, Guaglione E, Leon PE, D'Aloisio R, Vattovani O, Ravalico G, and Tognetto D

Abstract

Purpose. To report a case of unilateral optic neuritis following Measles-Mumps-Rubella (MMR) vaccination. Methods. A 30-year-old female developed unilateral optic neuritis five days after a Measles-Mumps-Rubella (MMR) booster vaccination. The patient displayed unilateral involvement, with severe visual loss. However, visual acuity improved significantly after four days of intravenous steroid therapy with 500 mg/day of methylprednisolone. Conclusions. Optic neuritis is one of the rare complications associated with the mumps, measles, and rubella vaccine. It may be a toxic reaction to the nonviral component of the vaccine, but the exact etiology is unknown. Postvaccination neuritis is generally bilateral and usually affects children. In adults, unilateral optic neuritis is usually correlated with multiple sclerosis (MS).

Published
2016
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35. GDx-VCC performance in discriminating normal from glaucomatous eyes with early visual field loss.

Author

Da Pozzo S, Fuser M, Vattovani O, Di Stefano G, and Ravalico G

Subjects
Aged, Birefringence, Cornea physiology, Diagnostic Techniques, Ophthalmological instrumentation, Humans, Intraocular Pressure, Lasers, Likelihood Functions, Middle Aged, ROC Curve, Sensitivity and Specificity, Visual Acuity, Diagnostic Techniques, Ophthalmological standards, Glaucoma, Open-Angle diagnosis, Nerve Fibers pathology, Optic Nerve Diseases diagnosis, Retinal Ganglion Cells pathology, Vision Disorders diagnosis, Visual Fields
Abstract

Background: To evaluate the ability of scanning laser polarimetry with variable corneal compensation (GDx-VCC) in separating healthy from glaucomatous patients with early visual field (VF) loss., Methods: Sixty-two healthy and 48 glaucomatous age-matched patients with early glaucoma [mean deviation (MD): -1.74dB +/-1.69] underwent complete ophthalmological evaluation, automated achromatic perimetry (AAP) and retinal nerve fiber layer (RNFL) measurement with GDx-VCC. One randomly selected eye from each subject was considered. Glaucomatous VF defects had either Glaucoma Hemifield Test (GHT) outside normal limits or pattern standard deviation (PSD) outside 95% confidence limits. Mean (+/-SD) MD, PSD and GDx-VCC parameters in the two groups were compared by t-test. For each GDx-VCC parameter, area under receiver operating characteristics (AUROC) curve and sensitivity at predetermined specificity > or =80% and > or =95% were calculated. Moreover, the parameter with largest AUROC was evaluated by likelihood ratios (LRs)., Results: Mean values for MD, PSD and ten of 14 GDx-VCC parameters were significantly different between the two groups (P<0.001). The three parameters with largest AUROCs were the nerve fiber indicator (NFI) (0.870), superior average (0.817) and normalized superior area (0.816) (P=0.08 for differences between AUROCs). NFI displayed sensitivity values of 80.2% and 60.4% for specificity > or =80% and > or =95%, respectively. At NFI cutoff value of 30, positive LR was 34.9 (95% CI: 4.9-247.6) and negative LR was 0.45 (95% CI: 0.32-0.61). Interval LRs showed large effect on post-test probability for NFI values < or =18 or > or =31., Conclusions: In our sample of eyes with early VF loss, GDx-VCC showed moderate-to-good discriminating ability. Among the best performing parameters, NFI had the largest AUROC, but several glaucomatous eyes (21, 43.8%) had NFI <30. This suggests that algorithm for NFI calculation requires some refinement when eyes with early VF loss are evaluated.

Published
2006
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36. Scanning laser polarimetry of nerve fiber layer thickness in normal eyes after cataract phacoemulsification and foldable intraocular lens implantation.

Author

Iacono P, Da Pozzo S, Vattovani O, Tognetto D, and Ravalico G

Subjects
Acrylic Resins, Aged, Aged, 80 and over, Diagnostic Techniques, Ophthalmological, Female, Humans, Lasers, Lenses, Intraocular, Male, Postoperative Period, Prospective Studies, Silicone Elastomers, Lens Implantation, Intraocular, Nerve Fibers pathology, Phacoemulsification, Retinal Ganglion Cells pathology
Abstract

Purpose: To assess the effect of cataract phacoemulsification and intraocular lens (IOL) implantation on retinal nerve fiber layer (RNFL) thickness using scanning laser polarimetry (SLP)., Setting: Eye Clinic, Trieste University, Italy., Methods: Forty-eight eyes were evaluated prospectively the day before and 30 days after cataract phacoemulsification and foldable IOL implantation. In each eye, lens opacity grading according to the Lens Opacities Classification System III (LOCS III), and axial length (AL) measurements were performed. Retinal nerve fiber layer thickness was quantified at baseline by means of SLP and anterior segment birefringence compensation was evaluated acquiring macular retardation map (MRM). Acrylic and silicone IOLs were implanted randomly. After surgery, RNFL thickness was reevaluated, and MRM was reacquired. Macular retardation map pattern variations regarding baseline profile were classified into 3 groups: no variation, bow-tie profile enhancement, or attenuation. Distribution of IOL power, AL, and cataract type in the 3 groups was assessed, as were presurgery and postsurgery SLP parameters with mean values (+/-SD) compared by paired t test., Results: Twenty-two eyes (Group 1, 45.8%) showed no MRM variation, 14 (Group 2, 29.2%) an enhancement, and 12 (Group 3, 25%) an attenuation. In Group 1, no significant RNFL thickness variation occurred. In Group 2, variation 10% to 15% was measured, whereas thickening a 8% to 15% thinning appeared in Group 3. Variations occurred irrespective of IOL material, AL, or cataract type., Conclusions: Cataract surgery with IOL implantation was associated with an MRM profile change and RNFL thickness variations in 54.2% of eyes. Variations are probably related to opacified lens removal. A new baseline SLP reading is mandatory after cataract surgery.

Published
2005
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37. Lens epithelial cell reaction after implantation of different intraocular lens materials: two-year results of a randomized prospective trial.

Author

Tognetto D, Toto L, Sanguinetti G, Cecchini P, Vattovani O, Filacorda S, and Ravalico G

Subjects
Adult, Aged, Aged, 80 and over, Biocompatible Materials, Cataract etiology, Cataract pathology, Fibrosis, Humans, Lens Capsule, Crystalline pathology, Middle Aged, Minimally Invasive Surgical Procedures, Ophthalmoscopy, Phacoemulsification, Photography, Prospective Studies, Risk Factors, Visual Acuity, Epithelial Cells pathology, Foreign-Body Reaction etiology, Lens Implantation, Intraocular adverse effects, Lens, Crystalline pathology, Lenses, Intraocular
Abstract

Purpose: To determine the influence of intraocular lens (IOL) material on anterior capsular opacification and membrane growth over the anterior IOL surface in patients who have undergone standardized small-incision cataract surgery and foldable IOL implantation in the capsular bag., Design: Randomized controlled trial., Participants: Eighty-eight cataract patients (88 eyes)., Methods: Patients were randomly assigned to receive one of four different foldable IOLs after phacoemulsification: Storz Hydroview H60M, Corneal ACR6D, AMO SI40NB, and Alcon AcrySof MA60BM. Examinations on days 7, 30, 90, 180, 360, and 720 after surgery included ophthalmologic examination, slit-lamp biomicroscopy, and photography using red reflex and focal illumination of the anterior IOL surface., Main Outcome Measures: Best-corrected visual acuity was measured at each examination. In addition, the anterior capsule opacification and the membrane growth on the anterior IOL surface were graded according to a subjective method by the same researcher., Results: The fibrosis of the anterior capsule was more frequently observed in the group using Corneal ACR6D and AMO SI40NB. The Hydroview and ACR6D groups showed a higher percentage of cases with membrane growth from the rhexis edge on the anterior IOL surface. AcrySof showed the lowest presence of fibrosis of the anterior capsule, and no membrane growth was noted., Conclusions: Anterior capsule opacification is an index of IOL biocompatibility. The natural location of lens epithelial cells (LECs) precludes the possibility of the IOL's design influencing the anterior capsule behavior. The local response of LECs varies according to the IOL studied. This may be related to the chemical and physical properties of the materials used in the different IOLs.

Published
2003
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38. Retinal detachment after cataract extraction and refractive lens exchange in highly myopic patients.

Author

Ravalico G, Michieli C, Vattovani O, and Tognetto D

Subjects
Adult, Aged, Aged, 80 and over, Female, Humans, Light Coagulation, Male, Middle Aged, Myopia physiopathology, Refraction, Ocular, Retina surgery, Retinal Perforations etiology, Retrospective Studies, Treatment Outcome, Vitreous Detachment etiology, Cataract complications, Cataract Extraction adverse effects, Lenses, Intraocular adverse effects, Myopia complications, Retinal Detachment etiology
Abstract

Purpose: To assess the refractive effects and incidence of postoperative complications in patients with high myopia after cataract extraction., Setting: University Eye Clinic, Trieste, Italy., Methods: This noncomparative retrospective study comprised all eyes (N = 388) having cataract extraction and implantation of an intraocular lens with a power less than 11.0 diopters (D) between 1986 and 1999. The preoperative and postoperative refractions; preoperative, postoperative, and final best corrected visual acuity (BCVA); and postoperative complications were analyzed. The mean follow-up was 47.16 months +/- 32.83 (SD) (range 8 to 146 months)., Results: Phacoemulsification was performed in 237 eyes, extracapsular cataract extraction in 147 eyes, and intracapsular cataract extraction in 4 eyes. The mean preoperative BCVA was 0.20 +/- 0.21 and the mean postoperative BCVA, 0.58 +/- 0.32. At the final evaluation, the mean BCVA was 0.50 +/- 0.33. The mean refraction was -15.95 +/- 5.86 D preoperatively and -2.00 +/- 1.62 D postoperatively. One eye (0.26%) developed a retinal detachment postoperatively. Of the 127 eyes (32.73%) having a neodymium:YAG laser capsulotomy for posterior capsule opacification, 1 had a macular retinal hole. Posterior detachment of the vitreous occurred in 78.6% of cases. Peripheral retinal photocoagulation was required in 8 cases postoperatively., Conclusion: Refractive lens exchange led to good functional results and a low incidence of postoperative complications and can thus be regarded as a viable technique to correct high myopia associated with cataract. However, further study is required before it can be routinely recommended for the correction of high myopia in eyes with a transparent crystalline lens.

Published
2003
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39. Correlation between the retinal nerve fiber layer thickness and the pattern electroretinogram amplitude.

Author

Toffoli G, Vattovani O, Cecchini P, Pastori G, Rinaldi G, and Ravalico G

Subjects
Adolescent, Adult, Aged, Female, Humans, Lasers, Male, Middle Aged, Ocular Hypertension diagnosis, Visual Field Tests methods, Electroretinography, Glaucoma, Open-Angle diagnosis, Nerve Fibers pathology, Optic Nerve pathology, Retinal Ganglion Cells pathology
Abstract

Objective: To establish a correlation between the retinal nerve fiber layer (RNFL) thickness measured by a scanning laser polarimeter (GDx) and the pattern electroretinogram (p-ERG) amplitudes in a heterogeneous population sample composed of normal subjects, ocular hypertensive and glaucomatous patients., Methods: 112 subjects were considered: 40 glaucomatous patients, 39 ocular hypertensive and 33 normal subjects. All were examined with the GDx, and the RNFL thickness was measured. A transient p-ERG was then recorded., Results: A statistically significant correlation was observed between the RNFL thickness and the p-ERG amplitudes (p < 0.001) by means of linear regression analysis., Conclusion: We observed a strict correlation between the measurements of the RNFL thickness obtained with the GDx and the amplitude of the p-ERG signal. These techniques represent additional objective tools to detect an early glaucomatous damage., (Copyright 2002 S. Karger AG, Basel)

Published
2002
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40. Corneal endothelial function in diabetes: a fluorophotometric study.

Author

Ravalico G, Tognetto D, Palomba M, Calderini S, and Vattovani O

Subjects
Aged, Anthropometry, Biological Transport, Active, Cell Membrane Permeability, Cornea anatomy & histology, Diabetes Mellitus, Type 1 physiopathology, Diabetes Mellitus, Type 2 physiopathology, Fluorophotometry, Humans, Diabetic Retinopathy physiopathology, Endothelium, Corneal physiology
Abstract

The corneal endothelium in diabetics is particularly susceptible to surgical trauma. This is related to the presence of morphological alterations of endothelial cells and to a supposedly concomitant functional failure of the endothelium in these patients. The aim of our study was to evaluate the corneal endothelial function in diabetics. A fluorophotometric study was performed on 3 groups of diabetic subjects without retinopathy, with nonproliferative retinopathy and with proliferative retinopathy compared with an age-matched control group. We evidenced a significant increase in corneal thickness and in passive corneal permeability in diabetics with severe retinal involvement. These findings are not related with a proportional significant increase in endothelial pump function. We suggest an altered regulation in corneal hydration in diabetic patients depending on the functional failure of endothelial cells that is likely to be connected with corneal biochemical modifications caused by an altered glucidic metabolism.

Published
1994
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