Search

Your search keyword '"Vasuri, Francesco"' showing total 520 results
Start Over Author "Vasuri, Francesco"
520 results on '"Vasuri, Francesco"'

6. MiR-494 induces metabolic changes through G6pc targeting and modulates sorafenib response in hepatocellular carcinoma

Author

Bergamini, Christian, Leoni, Ilaria, Rizzardi, Nicola, Melli, Mattia, Galvani, Giuseppe, Coada, Camelia Alexandra, Giovannini, Catia, Monti, Elisa, Liparulo, Irene, Valenti, Francesca, Ferracin, Manuela, Ravaioli, Matteo, Cescon, Matteo, Vasuri, Francesco, Piscaglia, Fabio, Negrini, Massimo, Stefanelli, Claudio, Fato, Romana, Gramantieri, Laura, and Fornari, Francesca

Published
2023
Full Text
View/download PDF

9. Porto-sinusoidal vascular disorder in surgical candidates for liver metastases: Prevalence, noninvasive diagnosis, and burden on surgical outcomes.

Author

Dajti, Elton, Serenari, Matteo, Malvi, Deborah, Dajti, Gerti, Ravaioli, Federico, Colecchia, Luigi, Marasco, Giovanni, Caputo, Francesca, Renzulli, Matteo, Vasuri, Francesco, Vestito, Amanda, Azzaroli, Francesco, Barbara, Giovanni, Ravaioli, Matteo, Festi, Davide, D'Errico, Antonietta, Cescon, Matteo, and Colecchia, Antonio

Published
2025
Full Text
View/download PDF

17. Donors risk assessment in transplantation: From the guidelines to their real-world application

Author

Malvi, D, Vasuri, F, Albertini, E, Carbone, M, Novelli, L, Mescoli, C, Cardillo, M, Pagni, F, D'Errico, A, Eccher, A, Malvi, Deborah, Vasuri, Francesco, Albertini, Elisa, Carbone, Maurizio, Novelli, Luca, Mescoli, Claudia, Cardillo, Massimo, Pagni, Fabio, D'Errico, Antonia, Eccher, Albino, Malvi, D, Vasuri, F, Albertini, E, Carbone, M, Novelli, L, Mescoli, C, Cardillo, M, Pagni, F, D'Errico, A, Eccher, A, Malvi, Deborah, Vasuri, Francesco, Albertini, Elisa, Carbone, Maurizio, Novelli, Luca, Mescoli, Claudia, Cardillo, Massimo, Pagni, Fabio, D'Errico, Antonia, and Eccher, Albino

Abstract

Transplantation of an organ from a donor carries an unavoidable risk of tumor transmission. The need to extend the donor pool increases the use of organs from donors with malignancies and potential disease transmission is a constant tension influencing donor suitability decisions. Current classification systems for the assessment of donor malignancy transmission risk have evolved from reports of potential transmission events in recipients to national donation and transplant surveillance agencies. Although the risk of malignancy transmission is very low in the general transplant setting it must constantly be balanced with the transplant benefits. Guidelines are mainly based on large registries and sparse case reports of transmission, so they cannot cover all the possible situations. For this reason, in 2004 in Italy, the National Transplant Center gave rise to the Second Opinion Service, charged by the Ministry of Health, by structuring expertise in diagnostic oncology and risk transmission and making it available to the Italian Transplant Centers. In this paper the registry of the Italian Oncological Second Opinion was reviewed, from 2016 to 2018, to detail the most frequent and problematic neoplastic topics addressed, those are separately reported and discussed. Furthermore, a review of the most recent strategies and risk stratification is provided, according to the most recent literature evidence and to the European Guidelines.

Published
2024

20. Circulating CXCL9, monocyte percentage, albumin, and C-reactive protein as a potential, non-invasive, molecular signature of carotid artery disease in 65+ patients with multimorbidity: a pilot study in Age.It.

Author

Capri, Miriam, Fronterrè, Sara, Collura, Salvatore, Giampieri, Enrico, Carrino, Sara, Feroldi, Francesca Maria, Ciurca, Erika, Conte, Maria, Olivieri, Fabiola, Ullo, Ines, Pini, Rodolfo, Vacirca, Andrea, Astolfi, Annalisa, Vasuri, Francesco, La Manna, Gaetano, Pasquinelli, Gianandrea, and Gargiulo, Mauro

Subjects
CAROTID artery diseases, CAROTID artery stenosis, ASYMPTOMATIC patients, RECEIVER operating characteristic curves, VASCULAR surgery
Abstract

Background: Carotid endarterectomy (CEA) for the prevention of upcoming vascular and cerebral events is necessary in patients with high-grade stenosis (=70%). In the framework of the Italian National project Age.It, a pilot study was proposed aiming at the discovery of amolecular signature with predictive potential of carotid stenosis comparing 65+ asymptomatic and symptomatic inpatients. Methods: A total of 42 inpatients have been enrolled, including 26 men and 16 women, with a mean age of 74 ± 6 years. Sixteen symptomatic and 26 asymptomatic inpatients with =70% carotid stenosis underwent CEA, according to the recommendations of the European Society for Vascular Surgery and the Society for Vascular Surgeons. Plaque biopsies and peripheral blood samples from the same individuals were obtained. Hematobiochemical analyses were conducted on all inpatients, and plasma cytokines/molecules, such as microRNAs (miRs), IL-6, sIL-6Ralpha, sgp130, myostatin (GDF8), follistatin, activin A, CXCL9, FGF21, and fibronectin, were measured using the ELISA standard technique. MiR profiles were obtained in the discovery phase including four symptomatic and four asymptomatic inpatients (both plasma and plaque samples), testing 734 miRs. MiRs emerging from the profiling comparison were validated through RT-qPCR analysis in the total cohort. Results and conclusion: The two groups of inpatients differ in the expression levels of blood c-miRs-126-5p and -1271-5p (but not in their plaques), which are more expressed in symptomatic subjects. Three cytokines were significant between the two groups: IL-6, GDF8, and CXCL9. Using receiver operating characteristic (ROC) analysis with a machine learning-based approach, the most significant blood molecular signature encompasses albumin, C-reactive protein (CRP), the percentage of monocytes, and CXCL9, allowing for the distinction of the two groups (AUC = 0.83, 95% c.i. [0.85, 0.81], p = 0.0028). The potential of the molecular signature will be tested in a second cohort of monitored patients, allowing the application of a predictive model and the final evaluation of cost/benefit for an assessable screening test. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

21. Immunohistochemical and Ultrastructural Characterization of Telocytes in Normal and Diabetic Human Kidneys.

Author

Valente, Sabrina, Villacampa Lahoz, Marta, Vasuri, Francesco, and Pasquinelli, Gianandrea

Subjects
ORGANS (Anatomy), DIABETIC nephropathies, INTERSTITIAL cells, TRANSMISSION electron microscopy, EXTRACELLULAR matrix
Abstract

Background: Telocytes are interstitial stromal cells identified in various human organs, including the kidney. Their presence and role in human diabetic kidney disease remain unknown. Methods: To identify and localize telocytes in glomerular and tubule-interstitial compartments, both normal and diabetic human renal tissues were examined using immunohistochemistry, immunofluorescence, and transmission electron microscopy. Results: Renal telocytes are elongated interstitial cells with long, thin telopodes, showing alternating thin and thick segments. They expressed CD34, Nestin, α-SMA, and Vimentin markers. Occasionally, c-Kit expression was observed in some rounded and spindle cells, while no positivity was detected for PDGFR-β and NG2. Telocytes were identified around Bowman's capsule, tubules, and peritubular capillaries in both normal and diabetic conditions. In diabetic renal samples, there was a significant increase in α-SMA expressing telocytes, leading to periglomerular fibrosis. These telocytes also exhibited a synthetic phenotype with proteoglycan deposition in the extracellular matrix and, in some cases, showed pre-adipocytic differentiation. Conclusions: Telocytes were identified in normal and diabetic human kidneys. These cells form an elastic mechanical scaffold in the interstitium and are present in all renal cortical compartments. In diabetic samples, their increased α-SMA expression and synthetic phenotype suggest their potential role in the pathogenesis of diabetic nephropathy. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

22. The role of cold ischemia time and hypothermic perfusion in predicting early hepatocellular carcinoma recurrences after liver transplantation.

Author

Dajti, Gerti, Germinario, Giuliana, Prosperi, Enrico, Siniscalchi, Antonio, Vasuri, Francesco, Valente, Sabrina, Odaldi, Federica, Maroni, Lorenzo, Serenari, Matteo, Bertuzzo, Valentina, Laurenzi, Andrea, del Gaudio, Massimo, Cescon, Matteo, and Ravaioli, Matteo

Subjects
LIVER transplantation, HEPATOCELLULAR carcinoma, ISCHEMIA, PHYSIOLOGICAL effects of cold temperatures, DISEASE relapse, PERFUSION, MULTIVARIATE analysis
Abstract

Aim: The aim of the study was to identify predictors of early tumor recurrence in patients with hepatocellular carcinoma (HCC) after liver transplantation (LT). Methods: Retrospective cohort study in 237 consecutive liver recipients with HCC between 2016 and 2021. Multivariate logistic analysis was performed to identify predictors of early HCC recurrences. The impact of hypothermic‐oxygenated perfusion (HOPE) on outcome was analyzed after propensity score weighting. Results: Early recurrences were observed in 15 cases. Microvascular invasion (OR 3.737, 95% CI 1.246–11.206, p = 0.019) and cold ischemia time (OR 1.155, 95% CI 1.001–1.333, p = 0.049) were independently associated with a lower risk of HCC recurrences. After balancing for relevant variables, patients in the HOPE group had lower rates of tumor recurrence (weighted OR 0.126, 95% CI 0.016–0.989, p = 0.049) and higher recurrence free survival (weighted HR 0.132, 95% CI 0.017–0.999, p = 0.050). Conclusion: Reducing cold ischemia time and graft perfusion with HOPE can lead to lower rates of early HCC recurrences and higher recurrence‐free survival. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

28. Epidemiology of Hepatocellular Carcinoma

Author

Giunchi, Francesca, Vasuri, Francesco, Fiorentino, Michelangelo, Loda, Massimo, editor, Mucci, Lorelei A., editor, Mittelstadt, Megan L., editor, Van Hemelrijck, Mieke, editor, and Cotter, Maura Bríd, editor

Published
2017
Full Text
View/download PDF

32. Author Correction: Hypothermic Oxygenated New Machine Perfusion System in Liver and Kidney Transplantation of Extended Criteria Donors: First Italian Clinical Trial

Author

Ravaioli, Matteo, De Pace, Vanessa, Angeletti, Andrea, Comai, Giorgia, Vasuri, Francesco, Baldassarre, Maurizio, Maroni, Lorenzo, Odaldi, Federica, Fallani, Guido, Caraceni, Paolo, Germinario, Giuliana, Donadei, Chiara, Malvi, Deborah, Del Gaudio, Massimo, Bertuzzo, Valentina Rosa, Siniscalchi, Antonio, Ranieri, Vito Marco, D’Errico, Antonietta, Pasquinelli, Gianandrea, Morelli, Maria Cristina, Pinna, Antonio Daniele, Cescon, Matteo, and La Manna, Gaetano

Published
2020
Full Text
View/download PDF

33. Prognostic value of microRNA-21 in intra- and extrahepatic cholangiocarcinoma after radical resection: cohort study.

Author

Boyd, Lenka N C, Ali, Mahsoem, Comandatore, Annalisa, Brandi, Giovanni, Tavolari, Simona, Gaeta, Raffaele, Meijer, Laura L, Large, Tessa Y S Le, Riefolo, Mattia, Vasuri, Francesco, Morelli, Luca, Laarhoven, Hanneke W M van, Giovannetti, Elisa, Kazemier, Geert, and Garajová, Ingrid

Subjects
PROGNOSIS, CHOLANGIOCARCINOMA, MICRORNA, CLINICAL prediction rules, COHORT analysis, INFORMED consent (Medical law)
Abstract

This article explores the potential use of microRNA-21 (miR-21) as a prognostic marker for cholangiocarcinoma, a type of cancer that affects the bile ducts. The study analyzed data from patients who underwent surgery for cholangiocarcinoma and found that miR-21 expression was associated with overall survival. The researchers suggest that incorporating miR-21 into prognostic models could enhance risk assessment and provide more accurate prognosis estimates for cholangiocarcinoma patients. The study concludes that miR-21 could be a valuable independent predictor of overall survival in cholangiocarcinoma and may improve clinical decision-making for post-surgery patients. [Extracted from the article]

Published
2024
Full Text
View/download PDF

34. Collagen proportionate area (CPA) measurement of liver parenchyma and hepatocellular carcinoma (HCC) can predict HCC recurrence after liver resection

Author

Ravaioli, Federico, primary, Riefolo, Mattia, additional, Sicuro, Chiara, additional, Rossini, Benedetta, additional, Dajti, Elton, additional, Serenari, Matteo, additional, Cescon, Matteo, additional, D’Errico, Maria Antonietta, additional, Colecchia, Antonio, additional, and Vasuri, Francesco, additional

Published
2023
Full Text
View/download PDF

36. Liver

Author

Vasuri, Francesco, Malvi, Deborah, D’Errico, Antonia, Pinna, Antonio Daniele, editor, and Ercolani, Giorgio, editor

Published
2015
Full Text
View/download PDF

37. The Safety of Donor

Author

D’Errico, Antonia, Malvi, Deborah, Vasuri, Francesco, Pinna, Antonio Daniele, editor, and Ercolani, Giorgio, editor

Published
2015
Full Text
View/download PDF

39. Pre-Implantation Kidney Biopsies in Extended Criteria Donors: From On Call to Expert Pathologist, from Conventional Microscope to Digital Pathology

Author

Marletta, S, Di Bella, C, Catalano, G, Mastrosimini, M, Becker, J, Ernst, A, Rizzo, P, Caldonazzi, N, Vasuri, F, Malvi, D, Fanelli, G, Naccarato, G, Ghimenton, C, L'Imperio, V, Mescoli, C, Eccher, A, Furian, L, Pagni, F, Marletta, Stefano, Di Bella, Caterina, Catalano, Giovanni, Mastrosimini, Maria Gaia, Becker, Jan, Ernst, Angela, Rizzo, Paola Chiara, Caldonazzi, Nicolo, Vasuri, Francesco, Malvi, Deborah, Fanelli, Giuseppe Nicolo, Naccarato, Giuseppe, Ghimenton, Claudio, L'Imperio, Vincenzo, Mescoli, Claudia, Eccher, Albino, Furian, Lucrezia, Pagni, Fabio, Marletta, S, Di Bella, C, Catalano, G, Mastrosimini, M, Becker, J, Ernst, A, Rizzo, P, Caldonazzi, N, Vasuri, F, Malvi, D, Fanelli, G, Naccarato, G, Ghimenton, C, L'Imperio, V, Mescoli, C, Eccher, A, Furian, L, Pagni, F, Marletta, Stefano, Di Bella, Caterina, Catalano, Giovanni, Mastrosimini, Maria Gaia, Becker, Jan, Ernst, Angela, Rizzo, Paola Chiara, Caldonazzi, Nicolo, Vasuri, Francesco, Malvi, Deborah, Fanelli, Giuseppe Nicolo, Naccarato, Giuseppe, Ghimenton, Claudio, L'Imperio, Vincenzo, Mescoli, Claudia, Eccher, Albino, Furian, Lucrezia, and Pagni, Fabio

Abstract

The number of patients awaiting a kidney transplant is constantly rising but lack of organs leads kidneys from extended criteria donors (ECD) to be used to increase the donor pool. Pre-transplant biopsies are routinely evaluated through the Karpinski-Remuzzi score but consensus on its correlation with graft survival is controversial. This study aims to test a new diagnostic model relying on digital pathology to evaluate pre-transplant biopsies and to correlate it with graft outcomes. Pre-transplant biopsies from 78 ECD utilized as single kidney transplantation were scanned, converted to whole-slide images (WSIs), and reassessed by two expert nephropathologists using the Remuzzi-Karpinski score. The correlation between graft survival at 36 months median follow-up and parameters assigned by either WSI or glass slide score (GSL) by on-call pathologists was evaluated, as well as the agreement between the GSL and the WSIs score. No relation was found between the GSL assessed by on-call pathologists and graft survival (P = 0.413). Conversely, the WSI score assigned by the two nephropathologists strongly correlated with graft loss probability, as confirmed by the ROC curves analysis (DeLong test P = 0.046). Digital pathology allows to share expertise in the transplant urgent setting, ensuring higher accuracy and favoring standardization of the process. Its employment may significantly increase the predictive capability of the pre-transplant biopsy evaluation for ECD, improving the quality of allocation and patient safety.

Published
2023

40. Multi-Gene Next-Generation Sequencing Panel for Analysis of BRCA1/BRCA2 and Homologous Recombination Repair Genes Alterations Metastatic Castration-Resistant Prostate Cancer

Author

Maloberti, Thais, primary, De Leo, Antonio, additional, Coluccelli, Sara, additional, Sanza, Viviana, additional, Gruppioni, Elisa, additional, Altimari, Annalisa, additional, Zagnoni, Stefano, additional, Giunchi, Francesca, additional, Vasuri, Francesco, additional, Fiorentino, Michelangelo, additional, Mollica, Veronica, additional, Ferrari, Simona, additional, Miccoli, Sara, additional, Visani, Michela, additional, Turchetti, Daniela, additional, Massari, Francesco, additional, Tallini, Giovanni, additional, and de Biase, Dario, additional

Published
2023
Full Text
View/download PDF

42. Supplementary Material from MiR-30e-3p Influences Tumor Phenotype through MDM2/TP53 Axis and Predicts Sorafenib Resistance in Hepatocellular Carcinoma

Author

Gramantieri, Laura, primary, Pollutri, Daniela, primary, Gagliardi, Martina, primary, Giovannini, Catia, primary, Quarta, Santina, primary, Ferracin, Manuela, primary, Casadei-Gardini, Andrea, primary, Callegari, Elisa, primary, De Carolis, Sabrina, primary, Marinelli, Sara, primary, Benevento, Francesca, primary, Vasuri, Francesco, primary, Ravaioli, Matteo, primary, Cescon, Matteo, primary, Piscaglia, Fabio, primary, Negrini, Massimo, primary, Bolondi, Luigi, primary, and Fornari, Francesca, primary

Published
2023
Full Text
View/download PDF

43. Supplementary Figures from MiR-30e-3p Influences Tumor Phenotype through MDM2/TP53 Axis and Predicts Sorafenib Resistance in Hepatocellular Carcinoma

Author

Gramantieri, Laura, primary, Pollutri, Daniela, primary, Gagliardi, Martina, primary, Giovannini, Catia, primary, Quarta, Santina, primary, Ferracin, Manuela, primary, Casadei-Gardini, Andrea, primary, Callegari, Elisa, primary, De Carolis, Sabrina, primary, Marinelli, Sara, primary, Benevento, Francesca, primary, Vasuri, Francesco, primary, Ravaioli, Matteo, primary, Cescon, Matteo, primary, Piscaglia, Fabio, primary, Negrini, Massimo, primary, Bolondi, Luigi, primary, and Fornari, Francesca, primary

Published
2023
Full Text
View/download PDF

44. Data from MiR-30e-3p Influences Tumor Phenotype through MDM2/TP53 Axis and Predicts Sorafenib Resistance in Hepatocellular Carcinoma

Author

Gramantieri, Laura, primary, Pollutri, Daniela, primary, Gagliardi, Martina, primary, Giovannini, Catia, primary, Quarta, Santina, primary, Ferracin, Manuela, primary, Casadei-Gardini, Andrea, primary, Callegari, Elisa, primary, De Carolis, Sabrina, primary, Marinelli, Sara, primary, Benevento, Francesca, primary, Vasuri, Francesco, primary, Ravaioli, Matteo, primary, Cescon, Matteo, primary, Piscaglia, Fabio, primary, Negrini, Massimo, primary, Bolondi, Luigi, primary, and Fornari, Francesca, primary

Published
2023
Full Text
View/download PDF

45. Supplementary Tables from MiR-30e-3p Influences Tumor Phenotype through MDM2/TP53 Axis and Predicts Sorafenib Resistance in Hepatocellular Carcinoma

Author

Gramantieri, Laura, primary, Pollutri, Daniela, primary, Gagliardi, Martina, primary, Giovannini, Catia, primary, Quarta, Santina, primary, Ferracin, Manuela, primary, Casadei-Gardini, Andrea, primary, Callegari, Elisa, primary, De Carolis, Sabrina, primary, Marinelli, Sara, primary, Benevento, Francesca, primary, Vasuri, Francesco, primary, Ravaioli, Matteo, primary, Cescon, Matteo, primary, Piscaglia, Fabio, primary, Negrini, Massimo, primary, Bolondi, Luigi, primary, and Fornari, Francesca, primary

Published
2023
Full Text
View/download PDF

49. Interpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer

Author

Giunchi, Francesca, Jordahl, Kristina, Bollito, Enrico, Colecchia, Maurizio, Patriarca, Carlo, D’Errico, Antonietta, Vasuri, Francesco, Malvi, Deborah, Fornari, Alessandro, Bonetti, Luca Reggiani, Corti, Barbara, Papotti, Mauro, DeGiuli, Paolo, Loda, Massimo, Montironi, Rodolfo, Fiorentino, Michelangelo, and Rider, Jennifer R.

Published
2017
Full Text
View/download PDF

50. Additional file 1 of MiR-494 induces metabolic changes through G6pc targeting and modulates sorafenib response in hepatocellular carcinoma

Author

Bergamini, Christian, Leoni, Ilaria, Rizzardi, Nicola, Melli, Mattia, Galvani, Giuseppe, Coada, Camelia Alexandra, Giovannini, Catia, Monti, Elisa, Liparulo, Irene, Valenti, Francesca, Ferracin, Manuela, Ravaioli, Matteo, Cescon, Matteo, Vasuri, Francesco, Piscaglia, Fabio, Negrini, Massimo, Stefanelli, Claudio, Fato, Romana, Gramantieri, Laura, and Fornari, Francesca

Abstract

Additional file 1. Supplementary Tables.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results