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28 results on '"Vassalini, Paolo"'

7. Exploiting Bacteria for Improving Hypoxemia of COVID-19 Patients

Author

Trinchieri, Vito, primary, Marazzato, Massimiliano, additional, Ceccarelli, Giancarlo, additional, Lombardi, Francesca, additional, Piccirilli, Alessandra, additional, Santinelli, Letizia, additional, Maddaloni, Luca, additional, Vassalini, Paolo, additional, Mastroianni, Claudio Maria, additional, and d’Ettorre, Gabriella, additional

Published
2022
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8. Post-Traumatic Stress Disorder Trajectories the Year after COVID-19 Hospitalization

Author

Serra, Riccardo, primary, Borrazzo, Cristian, additional, Vassalini, Paolo, additional, Di Nicolantonio, Chiara, additional, Koukopoulos, Alexia E., additional, Tosato, Cecilia, additional, Cherubini, Flavio, additional, Alessandri, Francesco, additional, Ceccarelli, Giancarlo, additional, Mastroianni, Claudio Maria, additional, D’Ettorre, Gabriella, additional, and Tarsitani, Lorenzo, additional

Published
2022
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9. Oral Bacteriotherapy Reduces the Occurrence of Chronic Fatigue in COVID-19 Patients

Author

Santinelli, Letizia, primary, Laghi, Luca, additional, Innocenti, Giuseppe Pietro, additional, Pinacchio, Claudia, additional, Vassalini, Paolo, additional, Celani, Luigi, additional, Lazzaro, Alessandro, additional, Borrazzo, Cristian, additional, Marazzato, Massimiliano, additional, Tarsitani, Lorenzo, additional, Koukopoulos, Alexia E., additional, Mastroianni, Claudio M., additional, d'Ettorre, Gabriella, additional, and Ceccarelli, Giancarlo, additional

Published
2022
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10. SARS-CoV-2 Among Migrants Recently Arrived in Europe From Low- and Middle-Income Countries: Containment Strategies and Special Features of Management in Reception Centers

Author

Fabris, Silvia, primary, d'Ettorre, Gabriella, additional, Spagnolello, Ornella, additional, Russo, Alessandro, additional, Lopalco, Maurizio, additional, D'Agostino, Fausto, additional, Vassalini, Paolo, additional, Celani, Luigi, additional, Aronica, Raissa, additional, Gabrielli, Simona, additional, d'Ettorre, Gabriele, additional, Angeletti, Silvia, additional, Mastroianni, Claudio M., additional, Ciccozzi, Massimo, additional, and Ceccarelli, Giancarlo, additional

Published
2021
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12. Depressive Symptoms among Individuals Hospitalized with COVID-19: Three-Month Follow-Up

Author

Vassalini, Paolo, primary, Serra, Riccardo, additional, Tarsitani, Lorenzo, additional, Koukopoulos, Alexia E., additional, Borrazzo, Cristian, additional, Alessi, Federica, additional, Di Nicolantonio, Chiara, additional, Tosato, Cecilia, additional, Alessandri, Francesco, additional, Ceccarelli, Giancarlo, additional, Mastroianni, Claudio Maria, additional, and d’Ettorre, Gabriella, additional

Published
2021
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13. Antiretroviral Therapy Dampens Mucosal CD4+ T Lamina Propria Lymphocytes Immune Activation in Long-Term Treated People Living with HIV-1

Author

Lazzaro, Alessandro, primary, Innocenti, Giuseppe Pietro, additional, Santinelli, Letizia, additional, Pinacchio, Claudia, additional, De Girolamo, Gabriella, additional, Vassalini, Paolo, additional, Fanello, Gianfranco, additional, Mastroianni, Claudio Maria, additional, Ceccarelli, Giancarlo, additional, and d’Ettorre, Gabriella, additional

Published
2021
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14. Alteration of type I interferon response is associated with subclinical atherosclerosis in virologically suppressed HIV‐1‐infected male patients

Author

Santinelli, Letizia, primary, De Girolamo, Gabriella, additional, Borrazzo, Cristian, additional, Vassalini, Paolo, additional, Pinacchio, Claudia, additional, Cavallari, Eugenio Nelson, additional, Statzu, Maura, additional, Frasca, Federica, additional, Scordio, Mirko, additional, Bitossi, Camilla, additional, Viscido, Agnese, additional, Ceccarelli, Giancarlo, additional, Mancone, Massimo, additional, Mastroianni, Claudio Maria, additional, Antonelli, Guido, additional, d'Ettorre, Gabriella, additional, and Scagnolari, Carolina, additional

Published
2021
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16. Post-Traumatic Stress Symptoms in Healthcare Workers Dealing with the COVID-19 Pandemic: A Systematic Review

Author

d’Ettorre, Gabriele, primary, Ceccarelli, Giancarlo, additional, Santinelli, Letizia, additional, Vassalini, Paolo, additional, Innocenti, Giuseppe Pietro, additional, Alessandri, Francesco, additional, Koukopoulos, Alexia E., additional, Russo, Alessandro, additional, d’Ettorre, Gabriella, additional, and Tarsitani, Lorenzo, additional

Published
2021
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17. Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection

Author

Spagnolello, Ornella, primary, Pinacchio, Claudia, additional, Santinelli, Letizia, additional, Vassalini, Paolo, additional, Innocenti, Giuseppe Pietro, additional, De Girolamo, Gabriella, additional, Fabris, Silvia, additional, Giovanetti, Marta, additional, Angeletti, Silvia, additional, Russo, Alessandro, additional, Mastroianni, Claudio M., additional, Ciccozzi, Massimo, additional, Ceccarelli, Giancarlo, additional, and d’Ettorre, Gabriella, additional

Published
2021
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19. Unexpected increase of myocardial extracellular volume fraction in low cardiovascular risk HIV patients

Author

BORRAZZO, CRISTIAN, primary, d'Ettorre, Gabriella, additional, Ceccarelli, Giancarlo, additional, Pacilio, Massimiliano, additional, Santinelli, Letizia, additional, Cavallari, Eugenio Nelson, additional, Spagnolello, Ornella, additional, Silvestri, Valeria, additional, Vassalini, Paolo, additional, Scagnolari, Carolina, additional, Francone, Marco, additional, Mastroianni, Claudio Maria, additional, and Carbone, Iacopo, additional

Published
2020
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20. Improvement of neuropsychological performances and reduction of immune-activation markers after probiotic supplementation and change of life-style in an HIV positive male: targeting the microbiota to act on gut-brain axis

Author

Ceccarelli, Giancarlo, Vassalini, Paolo, Corano Scheri, Giuseppe, Cavallari, EUGENIO NELSON, Bianchi, Luigi, Gabriella Di Girolamo, Martiangela, Fratino, Vullo, Vincenzo, and D'Ettorre, Gabriella

Subjects
neuropsychological tests, CD4+, CD38+, gut-brain axis, Probiotics, HLA-DR+, HIV, central Nervous System, Cerebrospinal uid, gut-brain axis, central Nervous System, Cerebrospinal uid, CD4+, CD8+, CD38+, HLA-DR+, HIV, Probiotics, CD8+
Published
2017

23. Antiretroviral Therapy Dampens Mucosal CD4 + T Lamina Propria Lymphocytes Immune Activation in Long-Term Treated People Living with HIV-1.

Author

Lazzaro, Alessandro, Innocenti, Giuseppe Pietro, Santinelli, Letizia, Pinacchio, Claudia, De Girolamo, Gabriella, Vassalini, Paolo, Fanello, Gianfranco, Mastroianni, Claudio Maria, Ceccarelli, Giancarlo, and d'Ettorre, Gabriella

Subjects
HIV, ANTIRETROVIRAL agents, LYMPHOCYTE transformation, HIV infections, INTESTINAL mucosa, GASTROINTESTINAL system, T cells
Abstract

HIV infection is characterized by a severe deterioration of an immune cell-mediated response due to a progressive loss of CD4+ T cells from gastrointestinal tract, with a preferential loss of IL-17 producing Th cells (Th17), a specific CD4+ T cells subset specialized in maintaining mucosal integrity and antimicrobial inflammatory responses. To address the effectiveness of antiretroviral therapy (ART) in reducing chronic immunological dysfunction and immune activation of intestinal mucosa, we conducted a cross-sectional observational study comparing total IFN-γ-expressing (Th1) and IL-17-expressing (Th17) frequencies of CD4+ T lamina propria lymphocytes (LPLs) and their immune activation status between 11 male ART-naïve and 11 male long-term ART-treated people living with HIV-1 (PLWH) who underwent colonoscopy and retrograde ileoscopy for biopsies collection. Flow cytometry for surface and intracellular staining was performed. Long-term ART-treated PLWH showed lower levels of CD38+ and/or HLA-DR+ LPLs compared to ART-naïve PLWH. Frequencies of Th1 and Th17 LPLs did not differ between the two groups. Despite ART failing to restore the Th1 and Th17 levels within the gut mucosa, it is effective in increasing overall CD4+ T LPLs frequencies and reducing mucosal immune activation. [ABSTRACT FROM AUTHOR]

Published
2021
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25. Oral Bacteriotherapy Reduces the Occurrence of Chronic Fatigue in COVID-19 Patients

Author

Letizia Santinelli, Luca Laghi, Giuseppe Pietro Innocenti, Claudia Pinacchio, Paolo Vassalini, Luigi Celani, Alessandro Lazzaro, Cristian Borrazzo, Massimiliano Marazzato, Lorenzo Tarsitani, Alexia E. Koukopoulos, Claudio M. Mastroianni, Gabriella d'Ettorre, Giancarlo Ceccarelli, Santinelli, Letizia, Laghi, Luca, Innocenti, Giuseppe Pietro, Pinacchio, Claudia, Vassalini, Paolo, Celani, Luigi, Lazzaro, Alessandro, Borrazzo, Cristian, Marazzato, Massimiliano, Tarsitani, Lorenzo, Koukopoulos, Alexia E., Mastroianni, Claudio M., d'Ettorre, Gabriella, and Ceccarelli, Giancarlo

Subjects
Nutrition and Dietetics, Nutrition. Foods and food supply, chronic fatigue, COVID-19, probiotics, metabolomics, FAS, arginine, asparagine, lactate, Endocrinology, Diabetes and Metabolism, Arginine, Lactate, TX341-641, Asparagine, probiotic, Food Science, Nutrition, Original Research, metabolomic
Abstract

Long COVID refers to patients with symptoms as fatigue, “brain fog,” pain, suggesting the chronic involvement of the central nervous system (CNS) in COVID-19. The supplementation with probiotic (OB) would have a positive effect on metabolic homeostasis, negatively impacting the occurrence of symptoms related to the CNS after hospital discharge. On a total of 58 patients hospitalized for COVID-19, 24 (41.4%) received OB during hospitalization (OB+) while 34 (58.6%) taken only the standard treatment (OB–). Serum metabolomic profiling of patients has been performed at both hospital acceptance (T0) and discharge (T1). Six months after discharge, fatigue perceived by participants was assessed by administrating the Fatigue Assessment Scale. 70.7% of participants reported fatigue while 29.3% were negative for such condition. The OB+ group showed a significantly lower proportion of subjects reporting fatigue than the OB– one (p < 0.01). Furthermore, OB+ subjects were characterized by significantly increased concentrations of serum Arginine, Asparagine, Lactate opposite to lower levels of 3-Hydroxyisobutirate than those not treated with probiotics. Our results strongly suggest that in COVID-19, the administration of probiotics during hospitalization may prevent the development of chronic fatigue by impacting key metabolites involved in the utilization of glucose as well as in energy pathways.

Published
2021

26. Aseptic meningitis induced by intravenous immunoglobulins in a child with acute Epstein-Barr virus infection and thrombocytopenia.

Author

Vassalini P, Ajassa C, Di Ruscio V, Morace A, Vergari J, Tosato C, Savelloni G, and Mastroianni CM

Subjects
Acute Disease, Child, Preschool, Humans, Immunoglobulins, Intravenous administration & dosage, Male, Meningitis, Aseptic diagnosis, Epstein-Barr Virus Infections complications, Immunoglobulins, Intravenous adverse effects, Meningitis, Aseptic etiology, Thrombocytopenia etiology
Abstract

Drug-induced aseptic meningitis (DIAM) represents a diagnostic challenge since clinical and cerebrospinal fluid (CSF) findings may be indistinguishable from a bacterial meningitis. Intravenous immunoglobulin (IVIg) are commonly used in a variety of diseases, including inflammatory and autoimmune disorders. Although usually well-tolerated, various adverse effects have been reported. DIAM is a serious neurological side effect of IVIg therapy: albeit rare (0.067% of all IVIg infusions), the condition represents an important diagnostic challenge and should be considered by physicians. Here we report a case of an aseptic meningitis induced by IVIg therapy in a child with acute Epstein-Barr virus (EBV) infection and thrombocytopenia.

Published
2019

27. Recurrence of mixed cryoglobulinaemia vasculitis following influenza vaccination despite clearance of hepatitis C virus infection.

Author

Sollima S, Milazzo L, Vassalini P, Antinori S, and Galli M

Subjects
Antiviral Agents therapeutic use, Cryoglobulinemia virology, Hepatitis C drug therapy, Humans, Male, Middle Aged, Recurrence, Ribavirin therapeutic use, Sofosbuvir therapeutic use, Sustained Virologic Response, Vasculitis virology, Cryoglobulinemia etiology, Hepatitis C complications, Influenza Vaccines adverse effects, Vasculitis etiology
Published
2018

28. Effect of Legal Status on the Early Treatment Outcomes of Migrants Beginning Combined Antiretroviral Therapy at an Outpatient Clinic in Milan, Italy.

Author

Ridolfo AL, Oreni L, Vassalini P, Resnati C, Bozzi G, Milazzo L, Antinori S, Rusconi S, and Galli M

Subjects
Adult, CD4 Lymphocyte Count, Female, Health Status Disparities, Humans, Italy epidemiology, Lost to Follow-Up, Male, Middle Aged, Ambulatory Care Facilities, Anti-HIV Agents therapeutic use, HIV Infections drug therapy, Health Services Accessibility legislation & jurisprudence, Health Services Accessibility statistics & numerical data, Transients and Migrants legislation & jurisprudence, Transients and Migrants statistics & numerical data
Abstract

Objective: In a setting of free access to HIV care, we compared the early treatment outcomes of HIV-infected undocumented migrants (UMs), documented migrants (DMs), and Italian subjects., Methods: The clinical data of 640 Italians and 245 migrants who started combined antiretroviral therapy (cART) at an HIV clinic in Milan, Italy, were reviewed. The migrants were mainly Latin Americans (83 DMs and 56 UMs) or sub-Saharan Africans (52 DMs and 11 UMs), but a minority were of other origin (33 DMs and 10 UMs). Retention in follow-up and HIV suppression were compared between UMs, DMs, and natives 12 months ± 90 days after start of cART., Results: There were no significant between-group differences in the stage of HIV infection at the start of cART or the type of regimen received. The Latin American DMs and UMs included a higher proportion of transgender women than the other ethnic groups (P < 0.001). The UMs were less frequently followed up after 12 months than the DMs and natives (P = 0.004) and were more frequently permanently lost to follow-up (P < 0.001). UM status was an independent predictor of lost to follow-up (adjusted odds ratio 8.05, P < 0.001). The DMs and UMs were less frequently HIV suppressed after 12 months than the natives (78% and 80.7% vs 90.5%, P = 0.001), and Latin American migrants were significantly less likely to be virologically suppressed than the natives (adjusted odds ratio 0.30, P = 0.001)., Conclusions: Despite their free access to cART, subgroups of migrants facing multiple levels of vulnerability still have difficulties in gaining optimal HIV care.

Published
2017
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