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6 results on '"Vasiliki Kostadima"'

1. Neuroendocrine Cell Carcinoma of Unknown Primary Arising in Long Standing History of Multiple Sclerosis

Author

Stergios Boussios, Vasiliki Kostadima, Anna Batistatou, Ioannis Tourkantonis, George Fotopoulos, Maria I. Argyropoulou, and Nicholas Pavlidis

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Multiple sclerosis (MS) is a chronic autoimmune disease that targets myelinated axons in the central nervous system (CNS). Cancer of unknown primary site (CUP) is a well-recognised clinical disorder, accounting for 3–5% of all malignant epithelial tumors. CUP is clinically characterised as an aggressive disease with early dissemination. Studies of cancer risk in MS patients have shown inconsistent findings. An increased risk of malignancy in patients with MS has been suggested, but recently serious questions have been raised regarding this association. Use of disease-modifying therapies might contribute to an increased cancer risk in selected MS patients. The concurrence of MS and CUP is exceptionally rare. Here we describe the case of a neuroendocrine carcinoma of unknown primary diagnosed in a male patient with a nine-year history of MS. The discussion includes data from all available population-based register studies with estimates of certain malignancies in patients with MS.

Published
2015
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2. Transient myocardial ischemia due to corticosteroid use in a patient with multiple sclerosis diagnosed with myocardial perfusion imaging

Author

Dimitris-Nikiforos Kiortsis, Dimitrios Nikas, Afroditi Tsoumani, Andreas Fotopoulos, Chrissa Sioka, and Vasiliki Kostadima

Subjects
medicine.medical_specialty, Multiple Sclerosis, medicine.diagnostic_test, business.industry, Multiple sclerosis, Transient myocardial ischemia, Myocardial Ischemia, Myocardial Perfusion Imaging, MEDLINE, Middle Aged, Coronary Angiography, medicine.disease, Methylprednisolone, Myocardial perfusion imaging, Internal medicine, Cardiology, Humans, Medicine, Female, Radiology, Nuclear Medicine and imaging, Corticosteroid use, Cardiology and Cardiovascular Medicine, business, Glucocorticoids
Published
2020
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4. Deciphering anti-MOG IgG antibodies: Clinical and radiological spectrum, and comparison of antibody detection assays

Author

Iosif Xidakis, Dimitrios Parisis, Theodoros Karapanayiotides, Nikolaos Grigoriadis, John Elloul, Vasiliki Kostadima, Dimitra Papadimitriou, Marianthi Breza, Elisabeth Chroni, Christos Bakirtzis, Georgios Koutsis, Katerina Karagiorgou, Sygkliti-Henrietta Pelidou, Anastasios Orologas, Ioannis Markakis, Paraskevi Zisimopoulou, Konstantinos Notas, C. Kilidireas, Ioannis Nikolaidis, Maria Anagnostouli, Socrates J. Tzartos, Maria-Eleftheria Evangelopoulos, Thomas Maris, Dimitrios Tzanetakos, and John Tzartos

Subjects
Optic Neuritis, Encephalomyelitis, Myelitis, Myelin oligodendrocyte glycoprotein, Serology, 03 medical and health sciences, 0302 clinical medicine, immune system diseases, Medicine, Humans, Optic neuritis, 030212 general & internal medicine, Autoantibodies, Autoimmune encephalitis, Neuromyelitis optica, biology, business.industry, Neuromyelitis Optica, Autoantibody, medicine.disease, nervous system diseases, 3. Good health, Neurology, Immunoglobulin G, Immunology, biology.protein, Myelin-Oligodendrocyte Glycoprotein, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

IgG antibodies to myelin oligodendrocyte glycoprotein (MOG) detected by cell based assays (CBA) have been identified in a constantly expanding spectrum of CNS demyelinating disorders. However, a universally accepted CBA has not been adopted yet. We aimed to analyze the clinical and radiological features of patients with anti-MOG IgG1-antibodies detected with a live-cell CBA and to compare the three most popular MOG-CBAs. We screened sera from 1300 Greek patients (including 426 patients referred by our 8 clinics) suspected for anti-MOG syndrome, and 120 controls with the live-cell MOG-CBA for IgG1-antibodies. 41 patients, versus 0 controls were seropositive. Clinical, serological and radiological data were available and analyzed for the 21 seropositive patients out of the 426 patients of our clinics. Their phenotypes were: 8 optic neuritis, 3 myelitis, 3 neuromyelitis optica, 2 encephalomyelitis, 2 autoimmune encephalitis and 3 atypical MS. We then retested all sera of our 426 patients with the other two most popular MOG-CBAs for total IgG (a live-cell and a commercial fixed-cell CBAs). Seven IgG1-seropositive patients were seronegative for one or both IgG-CBAs. Yet, all 21 patients had clinical and radiological findings previously described in MOG-antibody associated demyelination disease supporting the high specificity of the IgG1-CBA. In addition, all IgG1-CBA-negative sera were also negative by the IgG-CBAs. Also, all controls were negative by all three assays, except one serum found positive by the live IgG-CBA. Overall, our findings support the wide spectrum of anti-MOG associated demyelinating disorders and the superiority of the MOG-IgG1 CBA over other MOG-CBAs.

Published
2019

5. Cerebral venous thrombosis in an adolescent with ulcerative colitis

Author

Anastasia K. Zikou, Athanassios P. Kyritsis, Maria I. Argyropoulou, Vasiliki Kostadima, Maria Diakou, and Sotirios Giannopoulos

Subjects
Male, medicine.medical_specialty, Low protein, Adolescent, Gastroenterology, Protein S, Developmental Neuroscience, Internal medicine, medicine, Humans, Colitis, Cerebral venous sinus thrombosis, Venous Thrombosis, biology, business.industry, Warfarin, Anticoagulants, General Medicine, medicine.disease, Ulcerative colitis, Magnetic Resonance Imaging, Pathophysiology, Surgery, Venous thrombosis, Pediatrics, Perinatology and Child Health, biology.protein, Colitis, Ulcerative, Neurology (clinical), Intracranial Thrombosis, business, medicine.drug
Abstract

We describe a 17-year-old Caucasian adolescent with ulcerative colitis who presented with cerebral venous sinus thrombosis. Laboratory investigation revealed low protein S levels. With successful management the patient remained without neurologic sequalae. Although there may be an association between ulcerative colitis and cerebral venous sinus thrombosis, the exact pathophysiologic mechanism remains unknown.

Published
2010

6. Bilateral paramedian thalamic infarcts

Author

Aikaterini Selvi, Sotirios Giannopoulos, Panagiotis Nicolopoulos, Athanassios P. Kyritsis, and Vasiliki Kostadima

Subjects
Male, medicine.medical_specialty, Thalamus, Infarction, Disorders of Excessive Somnolence, Thalamus/*pathology, Disorders of Excessive Somnolence/etiology/pathology, Magnetic Resonance Imaging/methods, Arts and Humanities (miscellaneous), Dyslipidemias/etiology/pathology, Hypertension/etiology/pathology, Internal medicine, Cerebral Infarction/complications/*pathology, medicine, Humans, Dyslipidemias, business.industry, Cerebral Infarction, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Thalamic structure, Hypertension, Cardiology, Neurology (clinical), business
Abstract

Arch Neurol

Published
2006

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