Search

Your search keyword '"Vasili, Eftychia"' showing total 20 results
Start Over Author "Vasili, Eftychia"
20 results on '"Vasili, Eftychia"'

2. Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid

Author

Aubrey, Liam D., primary, Ninkina, Natalia, additional, Ulamec, Sabine M., additional, Abramycheva, Natalia Y., additional, Vasili, Eftychia, additional, Devine, Oliver M., additional, Wilkinson, Martin, additional, Mackinnon, Eilish, additional, Limorenko, Galina, additional, Walko, Martin, additional, Muwanga, Sarah, additional, Amadio, Leonardo, additional, Peters, Owen M., additional, Illarioshkin, Sergey N., additional, Outeiro, Tiago F., additional, Ranson, Neil A., additional, Brockwell, David J., additional, Buchman, Vladimir L., additional, and Radford, Sheena E., additional

Published
2024
Full Text
View/download PDF

4. miR-101a-3p Impairs Synaptic Plasticity and Contributes to Synucleinopathy

Author

Xylaki, Mary, primary, Paiva, Isabel, additional, Al-Azzani, Mohammed, additional, Gerhardt, Ellen, additional, Jain, Gaurav, additional, Islam, Md Rezaul, additional, Vasili, Eftychia, additional, Wassouf, Zinah, additional, Schulze-Hentrich, Julia M., additional, Fischer, André, additional, and Outeiro, Tiago Fleming, additional

Published
2023
Full Text
View/download PDF

5. Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity

Author

Brás, Inês C., primary, Khani, Mohammad H., additional, Vasili, Eftychia, additional, Möbius, Wiebke, additional, Riedel, Dietmar, additional, Parfentev, Iwan, additional, Gerhardt, Ellen, additional, Fahlbusch, Christiane, additional, Urlaub, Henning, additional, Zweckstetter, Markus, additional, Gollisch, Tim, additional, and Outeiro, Tiago F., additional

Published
2022
Full Text
View/download PDF

6. Correction: Dominguez-Meijide et al. Pharmacological Modulators of Tau Aggregation and Spreading. Brain Sci. 2020, 10 , 858.

Author

Dominguez-Meijide, Antonio, Vasili, Eftychia, and Outeiro, Tiago Fleming

Subjects
*ALZHEIMER'S disease, *TAU proteins, *TAUOPATHIES, *ALZHEIMER'S patients, *AMYLOID plaque
Abstract

This document is a correction notice for an article titled "Pharmacological Modulators of Tau Aggregation and Spreading" published in the journal Brain Sciences. The correction addresses an error in the original publication where several references were incorrect and unrelated to the main text. The correction provides the correct references for these citations. The authors state that the scientific conclusions of the article are unaffected by this error. [Extracted from the article]

Published
2024
Full Text
View/download PDF

9. α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity

Author

Ghanem, Simona S., primary, Majbour, Nour K., additional, Vaikath, Nishant N., additional, Ardah, Mustafa T., additional, Erskine, Daniel, additional, Jensen, Nanna Møller, additional, Fayyad, Muneera, additional, Sudhakaran, Indulekha P., additional, Vasili, Eftychia, additional, Melachroinou, Katerina, additional, Abdi, Ilham Y., additional, Poggiolini, Ilaria, additional, Santos, Patricia, additional, Dorn, Anton, additional, Carloni, Paolo, additional, Vekrellis, Kostas, additional, Attems, Johannes, additional, McKeith, Ian, additional, Outeiro, Tiago F., additional, Jensen, Poul Henning, additional, and El-Agnaf, Omar M. A., additional

Published
2022
Full Text
View/download PDF

11. Common molecular mechanisms underlie the transfer of alpha-synuclein, Tau and huntingtin and modulate spontaneous activity in neuronal cells

Author

Brás, Inês Caldeira, primary, Khani, Mohammad Hossein, additional, Vasili, Eftychia, additional, Möbius, Wiebke, additional, Riedel, Dietmar, additional, Parfentev, Iwan, additional, Gerhardt, Ellen, additional, Fahlbusch, Christiane, additional, Urlaub, Henning, additional, Zweckstetter, Markus, additional, Gollisch, Tim, additional, and Outeiro, Tiago Fleming, additional

Published
2021
Full Text
View/download PDF

13. Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo

Author

Dominguez-Meijide, Antonio, primary, Parrales, Valeria, additional, Vasili, Eftychia, additional, González-Lizárraga, Florencia, additional, König, Annekatrin, additional, Lázaro, Diana F., additional, Lannuzel, Annie, additional, Haik, Stéphane, additional, Del Bel, Elaine, additional, Chehín, Rosana, additional, Raisman-Vozari, Rita, additional, Michel, Patrick P., additional, Bizat, Nicolas, additional, and Outeiro, Tiago Fleming, additional

Published
2021
Full Text
View/download PDF

14. Pharmacological Modulators of Tau Aggregation and Spreading

Author

Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas, Domínguez Meijide, Antonio, Vasili, Eftychia, Outeiro, Tiago Fleming, Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas, Domínguez Meijide, Antonio, Vasili, Eftychia, and Outeiro, Tiago Fleming

Abstract

Tauopathies are neurodegenerative disorders characterized by the deposition of aggregates composed of abnormal tau protein in the brain. Additionally, misfolded forms of tau can propagate from cell to cell and throughout the brain. This process is thought to lead to the templated misfolding of the native forms of tau, and thereby, to the formation of newer toxic aggregates, thereby propagating the disease. Therefore, modulation of the processes that lead to tau aggregation and spreading is of utmost importance in the fight against tauopathies. In recent years, several molecules have been developed for the modulation of tau aggregation and spreading. In this review, we discuss the processes of tau aggregation and spreading and highlight selected chemicals developed for the modulation of these processes, their usefulness, and putative mechanisms of action. Ultimately, a stronger understanding of the molecular mechanisms involved, and the properties of the substances developed to modulate them, will lead to the development of safer and better strategies for the treatment of tauopathies

Published
2020

16. Doxycycline inhibits α-synuclein-associated pathologiesin vitroandin vivo

Author

Dominguez-Meijide, Antonio, primary, Parrales, Valeria, additional, Vasili, Eftychia, additional, González-Lizárraga, Florencia, additional, König, Annekatrin, additional, Lázaro, Diana F., additional, Lannuzel, Annie, additional, Haik, Stéphane, additional, Del Bel, Elaine, additional, Chehín, Rosana, additional, Raisman-Vozari, Rita, additional, Michel, Patrick P, additional, Bizat, Nicolas, additional, and Outeiro, Tiago Fleming, additional

Published
2020
Full Text
View/download PDF

17. Synucleinopathies: Where we are and where we need to go

Author

Brás, Inês Caldeira, primary, Dominguez‐Meijide, Antonio, additional, Gerhardt, Ellen, additional, Koss, David, additional, Lázaro, Diana F., additional, Santos, Patrícia I., additional, Vasili, Eftychia, additional, Xylaki, Mary, additional, and Outeiro, Tiago Fleming, additional

Published
2020
Full Text
View/download PDF

19. Spreading of alpha-synuclein and tau: a systematic comparison of the mechanisms involved

Author

Vasili, Eftychia, Dominguez-Meijide, Antonio, and Outeiro, Tiago Fleming

Subjects
Cellular and Molecular Neuroscience, alpha-synuclein, Parkinson’s disease, tau, Alzheimer’s disease, spreading, Parkinson's disease, Review, Alzheimer's disease, Molecular Biology, Neuroscience
Abstract

Alzheimer's disease (AD) and Parkinson's disease (PD) are age-associated neurodegenerative disorders characterized by the misfolding and aggregation of alpha-synuclein (aSyn) and tau, respectively. The coexistence of aSyn and tau aggregates suggests a strong overlap between tauopathies and synucleinopathies. Interestingly, misfolded forms of aSyn and tau can propagate from cell to cell, and throughout the brain, thereby templating the misfolding of native forms of the proteins. The exact mechanisms involved in the propagation of the two proteins show similarities, and are reminiscent of the spreading characteristic of prion diseases. Recently, several models were developed to study the spreading of aSyn and tau. Here, we discuss the mechanisms involved, the similarities and differences between the spreading of the two proteins and that of the prion protein, and the different cell and animal models used for studying these processes. Ultimately, a deeper understanding of the molecular mechanisms involved may lead to the identification of novel targets for therapeutic intervention in a variety of devastating neurodegenerative diseases. Open-Access-Publikationsfonds 2019 peerReviewed

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results