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Krukenberg tumor, also known as carcinoma mucocellulare, refers to a rare metastatic signet ring cell tumor of the ovary, the most common primary site being classically the gastrointestinal tract (the gastric carcinoma is responsible for 50% of Krukenberg tumors). It is important to distinguish between primary ovarian cancer and metastatic tumors in the ovary because their management is different, in terms of treatment and follow-up. We report the perioperative management of a 40-year-old female patient with bilateral Krukenberg tumors. [ABSTRACT FROM AUTHOR]

Non-invasive prenatal tests are tests which examine fetal DNA in maternal blood in order to establish the risk of fetal aneuploidies, analyzing chromosomes 21, 18 and 13 and the sex chromosomes X and Y. The tests were validated in women with singleton or twin pregnancies with the age of at least 10 weeks of gestation, and cannot exclude fetal chromosomal anomalies. In pregnancies with more than one fetus, they will not provide information about the sex chromosomes. This analysis does not replace chorionic villus biopsy, cordocentesis or amniocentesis. The objective of this paper is to analyze the applicability of sequencing chromosome selective cfDNA during non-invasive tests in order to establish an algorithm that includes the lower fractions from some viable twin pregnancy or ”vanishing twin syndrome”. [ABSTRACT FROM AUTHOR]