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1. Dynamics of the Trypanosoma cruzi infection in adipose tissue: Assessing gene expression of PNPLA2, FASN, and ACAT1 under Benzonidazole treatment and indirect mononuclear immune cells interaction

Author

da Silva, Ana Carla, Moreira, Leyllane Rafael, Oliveira, Cíntia Nascimento da Costa, Júnior, Claudeir Dias da Silva, Ó, Kleyton Palmeira do, Oliveira, Kamila Kássia Dos Santos, Melo, Maria Gabriella Nunes De, Soares, Ana Karine de Araújo, Cavalcanti, Milena de Paiva, Vasconcelos, Luydson Richardson Silva, and Lorena, Virginia Maria Barros de

Published
2024
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3. Polymorphisms and gene expression of metalloproteinases and their inhibitors associated with cerebral ischemic stroke in young patients with sickle cell anemia

Author

do Kleyton Palmeira, Ó., da Silva Freire, Ana Karla, de Nóbrega, Débora Nascimento, dos Santos Souza, Roberta, Farias, Isabela Cristina Cordeiro, de Mendonça Belmont, Taciana Furtado, da Silva, Andreia Soares, da Silva Arcanjo, Gabriela, da Silva Araujo, Aderson, dos Anjos, Ana Cláudia Mendonça, de Araujo, Antônio Roberto Lucena, Bezerra, Marcos André Cavalcanti, de Moura, Patricia Muniz Mendes Freire, do Socorro Mendonça Cavalcanti, Maria, and Vasconcelos, Luydson Richardson Silva

Published
2023
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6. Influence of LGALS3 and PNPLA3 genes in non-alcoholic steatohepatitis (NASH) in patients undergone bariatric surgery

Author

Azevedo Foinquinos, Gabriela, Azevedo Acioli, Maria Eduarda, Santana Cavalcanti, Antônio Henrique, Barbosa Junior, Walter Lins, Lima, Raul Emídio, Juca, Norma Thomé, de Azevedo Foinquinos, Rosa Cirne, Rocha da Cruz, Clarissa, Fernandez Pereira, Fernanda Maria, de Carvalho, Sylene Rampche, de Mendonça Belmont, Taciana Furtado, Vasconcelos, Luydson Richardson Silva, and Beltrão Pereira, Leila Maria Moreira

Published
2020
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10. Association of rs1285933 single nucleotide polymorphism in CLEC5A gene with dengue severity and its functional effects

Author

Xavier-Carvalho, Caroline, Cezar, Renata Duarte da Silva, Freire, Naishe Matos, Vasconcelos, Carla Maria Mola de, Solorzano, Victor Edgar Fiestas, de Toledo-Pinto, Thiago Gomes, Fialho, Luciana Gomes, do Carmo, Rodrigo Feliciano, Vasconcelos, Luydson Richardson Silva, Cordeiro, Marli Tenório, Baptista, Paulo, de Azeredo, Elzinandes leal, da Cunha, Rivaldo Venâncio, de Souza, Luiz José, Pacheco, Antonio Guilherme, Kubelka, Claire Fernandes, Moura, Patrícia Muniz Mendes Freire de, and Moraes, Milton Ozorio

Published
2017
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11. Human Genome Polymorphisms and Computational Intelligence Approach Revealed a Complex Genomic Signature for COVID-19 Severity in Brazilian Patients

Author

Pastor, André Filipe, primary, Docena, Cássia, additional, Rezende, Antônio Mauro, additional, Oliveira, Flávio Rosendo da Silva, additional, Sena, Marília de Albuquerque, additional, Morais, Clarice Neuenschwander Lins de, additional, Bresani-Salvi, Cristiane Campello, additional, Vasconcelos, Luydson Richardson Silva, additional, Valença, Kennya Danielle Campelo, additional, Mariz, Carolline de Araújo, additional, Brito, Carlos, additional, Fonseca, Cláudio Duarte, additional, Braga, Cynthia, additional, Reis, Christian Robson de Souza, additional, Marques, Ernesto Torres de Azevedo, additional, and Acioli-Santos, Bartolomeu, additional

Published
2023
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12. MicroRNA dysregulation in schistosomiasis-induced hepatic fibrosis: a systematic review

Author

Nóbrega, Débora Nascimento da, primary, Carvalho, Tatiana Lins, additional, do Ó, Kleyton Palmeira, additional, Lima, Raul Emídio de, additional, Farias, Isabela Cristina Cordeiro, additional, Souza, Roberta dos Santos, additional, Pereira, Julia Braga, additional, Maranhão, Augusto César Nascimento, additional, Lima, Victor Fernando da Silva, additional, Melo, Ana Luíza Trajano Mangueira de, additional, Silva, Thaysa Carolina Gonçalves, additional, Belmont, Taciana Furtado de Mendonça, additional, Gomes, Elainne Christine de Souza, additional, and Vasconcelos, Luydson Richardson Silva, additional

Published
2023
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13. Polymorphisms and expression of MMPs-TIMPs genes associated with cerebral ischemic stroke in young patients with sickle cell anemia

Author

Ó, Kleyton Palmeira do, primary, Freire, Ana Karla da Silva, additional, de Nóbrega, Debora Nascimento, additional, Souza, Roberta dos Santos, additional, Farias, Isabela Cristina Cordeiro, additional, Belmont, Taciana Furtado de Mendonça, additional, Silva, Andreia Soares da, additional, Arcanjo, Gabriela da Silva, additional, Araujo, Aderson da Silva, additional, Anjos, Ana Cláudia Mendonça dos, additional, de Araujo, Antônio Roberto Lucena, additional, Bezerra, Marcos André Cavalcanti, additional, de Moura, Patricia Muniz Mendes Freire, additional, Cavalcanti, Maria do Socorro Mendonça, additional, and Vasconcelos, Luydson Richardson Silva, additional

Published
2022
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16. Association of IL-6 -174 G/C and TNF-α - 308 G/A polymorphisms with periodontitis in patients undergoing hemodialysis

Author

Perez, Mariana de Moraes Corrêa, primary, Cavalcanti, Mariana Silva Teixeira, additional, Dantas, Fernanda Suely Barros, additional, Pessoa, Katarina Haluli Janô da Veiga, additional, Vasconcelos, Luydson Richardson Silva, additional, Gueiros, Luiz Alcino Monteiro, additional, Leão, Jair Carneiro, additional, and Carvalho, Alessandra Albuquerque Tavares, additional

Published
2022
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17. Aspects of cognitive assessments and spectroscopic magnetic resonance imaging in people with chronic hepatitis C: a systematic review.

Author

Carvalho, Tatiana Lins, Mertens Brainer de Queiroz Lima, Alessandra Cintia, de Araújo, Noemi Salazar, de Sousa Fernandes, Matheus Santos, Lira, Gabriela Barza, de Melo, Marcela Maria Medeiros, Vasconcelos, Luydson Richardson Silva, de Moura, Patrícia Muniz Mendes Freire, and da Cunha Correia, Carolina

Subjects
THOUGHT & thinking, MEMORY, EXECUTIVE function, CHRONIC hepatitis C, SYSTEMATIC reviews, COGNITIVE processing speed, NUCLEAR magnetic resonance spectroscopy, CHOLINE, CREATINE, ATTENTION, COGNITIVE testing, MEDLINE, ATTENTIONAL bias, INOSITOL, ASPARTIC acid
Abstract

Extrahepatic manifestations are common in people with hepatitis C virus (HCV). Cognitive changes are pointed out, but the mechanisms are still uncertain. The aim of this systematic review was to analyze studies involving spectroscopic magnetic resonance in people infected with HCV, which also included cognitive tests. The research occurred in six databases (Directory of Open Access Journals, Lilacs, Medcaribe, Medline, Scielo and ScienceDirect) and the selection of studies was carried out in two stages: search for titles and abstracts, then reading of the full articles, excluding those that did not meet the eligibility criteria. 12,888 titles and abstracts were selected, but only 6 articles were included in the review. Impairments in attention, concentration, speed of information processing, memory, verbal fluency and executive functions were identified as well as an increase in the Cho/Cr and mI/Cr ratios and a reduction in the NAA/Cr ratio in some included studies. Longitudinal studies, with more homogeneous samples and methods, as well as with better controlled confounding factors, are necessary to adequately identify the effect of HCV on the brain. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Liver expression of IL-22, IL-22R1 and IL-22BP in patients with chronic hepatitis C with different fibrosis stages

Author

de Brito, Rodrigo José Videres Cordeiro, primary, do Carmo, Rodrigo Feliciano, additional, Silva, Bruna Manuella Souza, additional, Costa, Ana Clara Santos, additional, Rocha, Sura Wanessa Santos, additional, Vasconcelos, Luydson Richardson Silva, additional, Pereira, Leila Maria Moreira Beltrão, additional, and de Moura, Patrícia Muniz Mendes Freire, additional

Published
2022
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20. Aspects of cognitive assessments and spectroscopic magnetic resonance imaging in people with chronic hepatitis C: a systematic review

Author

Carvalho, Tatiana Lins, primary, Mertens Brainer de Queiroz Lima, Alessandra Cintia, additional, de Araújo, Noemi Salazar, additional, de Sousa Fernandes, Matheus Santos, additional, Lira, Gabriela Barza, additional, de Melo, Marcela Maria Medeiros, additional, Vasconcelos, Luydson Richardson Silva, additional, de Moura, Patrícia Muniz Mendes Freire, additional, and da Cunha Correia, Carolina, additional

Published
2022
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21. Clinical and laboratory parameters associated with li-rads as diagnostic of liver nodule in patients with cirrhosis

Author

Cruz, Clarissa Rocha, primary, Carvalho, Ana Rita Marinho Ribeiro, additional, Maranhão, Augusto César Nascimento, additional, Aroucha, Dayse Barbosa, additional, Foinquinos, Gabriela Azevedo, additional, Carvalho, Sylene Rampche Coutinho, additional, Vasconcelos, Luydson Richardson Silva, additional, and Pereira, Leila Maria Moreira Beltrão, additional

Published
2021
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23. Ultrastructural analysis of nasopharyngeal epithelial cells from patients with SARS-CoV-2 infection

Author

Saraiva, Karina Lidianne Alcântara, primary, Vasconcelos, Luydson Richardson Silva, additional, Bezerra, Matheus Filgueira, additional, Arcoverde, Rodrigo Moraes Loyo, additional, Brandão-Filho, Sinval Pinto, additional, Ayres, Constância Flávia Junqueira, additional, de Figueiredo, Regina Célia Bressan Queiroz, additional, and Pereira-Neves, Antonio, additional

Published
2021
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24. The 1G/1G+1G/2G Genotypes ofMMP1rs1799750 Are Associated with Higher Levels of MMP-1 and Are Both Associated with Lipodystrophy in People Living with HIV on Antiretroviral Therapy

Author

Silva, Andreia Soares da, primary, Cavalcanti, Maria do Socorro de Mendonça, additional, Belmont, Taciana Furtado de Mendonça, additional, Ximenes, Ricardo Arraes de Alencar, additional, Silva, Aline Vieira da, additional, Nóbrega, Débora Nascimento da, additional, Souza, Roberta dos Santos, additional, Farias, Isabela Cristina Cordeiro, additional, do Ó, Kleyton Palmeira, additional, Vasconcelos, Luydson Richardson Silva, additional, Diniz, George Tadeu Nunes, additional, and Miranda-Filho, Demócrito de Barros, additional

Published
2021
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25. Multiple Introductions Followed by Ongoing Community Spread of SARS-CoV-2 at One of the Largest Metropolitan Areas of Northeast Brazil

Author

Paiva, Marcelo Henrique Santos, primary, Guedes, Duschinka Ribeiro Duarte, additional, Docena, Cássia, additional, Bezerra, Matheus Filgueira, additional, Dezordi, Filipe Zimmer, additional, Machado, Laís Ceschini, additional, Krokovsky, Larissa, additional, Helvecio, Elisama, additional, da Silva, Alexandre Freitas, additional, Vasconcelos, Luydson Richardson Silva, additional, Rezende, Antonio Mauro, additional, da Silva, Severino Jefferson Ribeiro, additional, Sales, Kamila Gaudêncio da Silva, additional, de Sá, Bruna Santos Lima Figueiredo, additional, da Cruz, Derciliano Lopes, additional, Cavalcanti, Claudio Eduardo, additional, Neto, Armando de Menezes, additional, da Silva, Caroline Targino Alves, additional, Mendes, Renata Pessôa Germano, additional, da Silva, Maria Almerice Lopes, additional, Gräf, Tiago, additional, Resende, Paola Cristina, additional, Bello, Gonzalo, additional, Barros, Michelle da Silva, additional, do Nascimento, Wheverton Ricardo Correia, additional, Arcoverde, Rodrigo Moraes Loyo, additional, Bezerra, Luciane Caroline Albuquerque, additional, Brandão-Filho, Sinval Pinto, additional, Ayres, Constância Flávia Junqueira, additional, and Wallau, Gabriel Luz, additional

Published
2020
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26. Relationship between Cognition, levels of PTX-3, MBL and their polymorphisms: A systematic review

Author

Carvalho, Tatiana Lins, primary, Belmont, Taciana Furtado de Mendonça, additional, Silva, Andreia Soares da, additional, Ó, Kleyton Palmeira do, additional, Silva, Lucas de Lucena Simões e, additional, Lima, Eline Autran de, additional, Vasconcelos, Luydson Richardson Silva, additional, Moura, Patrícia Muniz Mendes Freire de, additional, and Correia, Carolina da Cunha, additional

Published
2020
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27. Multiple introductions followed by ongoing community spread of SARS-CoV-2 at one of the largest metropolitan areas in the Northeast of Brazil

Author

Paiva, Marcelo Henrique Santos, primary, Guedes, Duschinka Ribeiro Duarte, additional, Docena, Cássia, additional, Bezerra, Matheus Filgueira, additional, Dezordi, Filipe Zimmer, additional, Machado, Laís Ceschini, additional, Krokovsky, Larissa, additional, Helvecio, Elisama, additional, Silva, Alexandre Freitas da, additional, Vasconcelos, Luydson Richardson Silva, additional, Rezende, Antonio Mauro, additional, Silva, Severino Jefferson Ribeiro da, additional, da Silva Sales, Kamila Gaudêncio, additional, Figueiredo de Sá, Bruna Santos Lima, additional, da Cruz, Derciliano Lopes, additional, Cavalcanti, Claudio Eduardo, additional, de Menezes Neto, Armando, additional, da Silva, Caroline Targino Alves, additional, Mendes, Renata Pessôa Germano, additional, da Silva, Maria Almerice Lopes, additional, da Silva Barros, Michelle, additional, Nascimento, Wheverton Ricardo Correia do, additional, Arcoverde, Rodrigo Moraes Loyo, additional, Bezerra, Luciane Caroline Albuquerque, additional, Filho, Sinval Pinto Brandão, additional, Ayres, Constância Flávia Junqueira, additional, and Wallau, Gabriel Luz, additional

Published
2020
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28. LGALS3 +191A and +292C polymorphisms are associated with a reduction in serum gal-3 levels, but not with the clinical events of individuals with sickle cell anemia

Author

Ó, Kleyton Palmeira do, primary, Mendonça-Belmont, Taciana Furtado de, additional, Farias, Isabela Cristina Cordeiro, additional, Silva, Andreia Soares da, additional, Freire, Ana Karla da Silva, additional, Moura, Patrícia Muniz Mendes Freire de, additional, Vasconcelos, Luydson Richardson Silva, additional, Araújo, Aderson da Silva, additional, Arcanjo, Gabriela da Silva, additional, Falcão, Diego Arruda, additional, Hatzlhofer, Betânia Lucena Domingues, additional, Lucena-Araújo, Antônio Roberto, additional, Bezerra, Marcos André Cavalcanti, additional, and Cavalcanti, Maria do Socorro de Mendonça, additional

Published
2020
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29. MBL2 gene polymorphisms are not related to the occurrence of cerebrovascular disease in sickle cell anemia

Author

Farias, Isabela Cristina Cordeiro, primary, Mendonça-Belmont, Taciana Furtado, additional, Moura, Patrícia Muniz Mendes Freire, additional, Domingos, Igor Farias, additional, Falcão, Diego Arruda, additional, Arcanjo, Gabriela Silva, additional, Hatzlhofer, Betânia Lucena Domingues, additional, Ó, Kleyton Palmeira do, additional, Farias, João Victor Cordeiro, additional, Silva, Andreia Soares da, additional, Vasconcelos, Luydson Richardson Silva, additional, Araújo, Aderson da Silva, additional, Anjos, Ana Cláudia Mendonça dos, additional, Lucena-Araújo, Antônio Roberto, additional, Cavalcanti, Maria do Socorro de Mendonça, additional, and Bezerra, Marcos André Cavalcanti, additional

Published
2020
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30. Cuidados paliativos em pessoas com carcinoma hepatocelular: uma revisão integrativa

Author

Freire, Ana Karla da Silva, primary, Belmont, Taciana Furtado de Mendonça, additional, Do Ó, Kleyton Palmeira, additional, Silva, Andreia Soares da, additional, Farias, Isabela Cristina Cordeiro, additional, Carvalho, Maria de Fátima Alves Aguiar, additional, Santiago, Edgo Jackson Pinto, additional, Cavalcanti, Maria do Socorro de Mendonça, additional, Medeiros, Zulma Maria de, additional, and Vasconcelos, Luydson Richardson Silva, additional

Published
2020
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31. Higher levels of TNF and IL‐4 cytokines and low miR‐182 expression in visceral leishmaniasis‐HIV co‐infected patients

Author

Barbosa Júnior, Walter Lins, primary, Justo, Alda Maria, additional, Aguiar dos Santos, Ana Maria, additional, de Lorena, Virginia Maria Barros, additional, do Carmo, Rodrigo Feliciano, additional, de Melo, Fábio Lopes, additional, de Medeiros, Zulma Maria, additional, and Vasconcelos, Luydson Richardson Silva, additional

Published
2020
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32. Expression of microRNAs (133b and 138) and Correlation with Echocardiographic Parameters in Patients with Alcoholic Cardiomyopathy

Author

de Araújo Melo, Leiliandry, primary, da Silveira, Maria Mariana Barros Melo, additional, de Vasconcellos Piscoya, Isabelle Cecília, additional, Brasileiro, Victor Arthur Eulálio, additional, Farias, Isabela Cristina Cordeiro, additional, do Ó, Kleyton Palmeira, additional, Roncal, Carlos Guilhermo Piscoya, additional, Lima, Raul Emídio, additional, Filho, Dário Celestino Sobral, additional, and Vasconcelos, Luydson Richardson Silva, additional

Published
2020
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33. Polymorphisms of CYP2C9*2, CYP2C9*3 and VKORC1 genes related to time in therapeutic range in patients with atrial fibrillation using warfarin

Author

Silveira,Maria Mariana, Melo,Leiliandry de Araújo, Gomes,Filipe, Andrade,Leonardo José, Serur,Isabela, Piscoya,Isabelle, Gueiros,Raposo, Palmeira do Ó,Kleyton, Lima,Raul, Brasileiro,Victor Arthur, Vasconcelos,Luydson Richardson Silva, and Sobral Filho,Dário

Subjects
The Application of Clinical Genetics
Abstract

Maria Mariana Barros Melo da Silveira,1,2 Leiliandry de Araújo Melo,1,2 Filipe Maia Ferreira Gomes,1 Leonardo José de Cupertino Barreto da Rocha Andrade,1 Isabela Paulino Serur,1 Isabelle Cecília de Vasconcellos Piscoya,1 Raposo Marina Gueiros,1 Kleyton Palmeira do Ó,1 Raul Emídio de Lima,3 Victor Arthur Eulálio Brasileiro,1,2 Luydson Richardson Silva Vasconcelos,1,3 Dário Celestino Sobral Filho21Faculdade de Ciências Médicas, Universidade de Pernambuco - FCM/UPE, Recife, Brazil; 2Pronto Socorro Cardiológico Professor Luiz Tavares - PROCAPE/UPE, Recife, Brazil; 3Instituto Aggeu Magalhães - FIOCRUZ-PE, Recife, BrazilIntroduction: Warfarin continues to be the most widely used anticoagulant in clinical practice around the world for the prevention of thromboembolic events in patients with atrial fibrillation (AF). The evaluation of the quality of anticoagulation control, estimated by time in therapeutic range (TTR), is accepted as a good method to evaluate the quality of anticoagulation. The variability of TTR can be explained by the presence of variants of the CYP2C9 and VKORC1 genes.Methods: This study examined the association between polymorphisms of the CYP2C9and VKORC1genes and control of oral anticoagulation, through TTR, in patients with AF. A cross-sectional study was conducted within a cohort follow-up. The study comprised of 317 patients with AF, using warfarin, who were followed up for one year. The genotyping of genes CYP2C9 (rs1057910), (rs1799853) and VKORC1 (rs923231) was performed by PCR in real time, using TaqMan probes.Results: Patients who had variant genotypes for the CYP2C9*3 gene (rs1057910) presented higher TTR (TTR 81–100%) when compared to when compared to the

Published
2019

34. Up-Regulation of Mir-21 and Mir-130a and Serum Leptin Levels on Leg Ulcers Development in Sickle Cell Anemia

Author

Batista, Thais Helena Chaves, primary, Santana, Rodrigo Marcionilo, primary, de Vasconcelos Costa Sobreira, Marcondes José, primary, Arcanjo, Gabriela da Silva, primary, Falcao, Diego Arruda, primary, Pereira-Martins, Diego A, primary, Araujo, Aderson da Silva, primary, Costa, Fernando Ferreira, primary, Saad, Mario José Abdalla, primary, Carvalho, Bruno de Melo, primary, Vasconcelos, Luydson Richardson Silva, primary, Lucena-Araujo, Antonio R., primary, and Bezerra, Marcos Andre Cavalcanti, primary

Published
2019
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35. Does physical exercise influence in the development of neuroeschistosomiasis?

Author

Carvalho, Tiago Pinheiro Vaz de, primary, Peixoto, Christina Alves, additional, Paiva, Igor Henrique Rodrigues de, additional, Arcoverde, Rodrigo Moraes Loyo, additional, Nascimento, Wheverton Correia do, additional, Vasconcelos, Luydson Richardson Silva, additional, Gomes, Elainne Christine de Souza, additional, and Barbosa, Constança Clara Gayoso Simões, additional

Published
2019
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36. The 1G/1G+1G/2G Genotypes of MMP1 rs1799750 Are Associated with Higher Levels of MMP-1 and Are Both Associated with Lipodystrophy in People Living with HIV on Antiretroviral Therapy.

Author

Silva, Andreia Soares da, Cavalcanti, Maria do Socorro de Mendonça, Belmont, Taciana Furtado de Mendonça, Ximenes, Ricardo Arraes de Alencar, Silva, Aline Vieira da, Nóbrega, Débora Nascimento da, Souza, Roberta dos Santos, Farias, Isabela Cristina Cordeiro, do Ó, Kleyton Palmeira, Vasconcelos, Luydson Richardson Silva, Diniz, George Tadeu Nunes, and Miranda-Filho, Demócrito de Barros

Abstract

In HIV-infected patients, antiretroviral therapy (ART) is associated to adipose tissue redistribution known as lipodystrophy (LD). This study aimed at verifying the association between the polymorphism of the MMP1 gene (rs1799750) (1G/2G) and the serum levels of matrix metalloproteinase 1 (MMP-1) with LD and its subtypes in people living with HIV on ART. This is a cross-secional study. LD was self-reported. The determination of the MMP1 rs1799750 gene polymorphism was performed by real-time PCR, and the serum concentrations of MMP-1 were quantified by the enzyme-linked immunosorbent assay (ELISA) method. Of 404 participants, 204 (51%) were diagnosed with LD, of whom 89 (43%) had mixed lipodystrophy (ML), 72 (35%) had lipohypertrophy (LH), and 43 (22%) had lipoatrophy (LA). There was an association between the genotypes 1G/1G+1G/2G and higher serum levels of MMP-1 (p = .025). There was no association of MMP1 (1G/2G) with LD. Other factors associated with LD were current CD4 ≤ 350 [odds ratio (OR) = 4.85, confidence interval (CI) = 1.78–47.99, p = .0033] and serum MMP-1 levels >6.81 (OR = 2.67, CI = 1.21–6.08, p = .0165). Factors associated with ML: current CD4 ≤ 350 (OR = 5.59, CI = 1.69–20.39, p = .006); with LH: number of antiretroviral regimens used: 2 (OR = 2.06, CI = 1.01–4.20, p = .0460) and 3+ (OR = 2.09, CI = 1.00–4.35, p = .0477), and current CD4 ≤ 350 (OR = 2.08, CI = 1.00–4.24, p = .0461); and with LA: current viral load >40 (OR = 2.52, CI = 1.03–5.91, p = .0372) and current use of zidovudine (OR = 2.97, CI = 1.32–6.54, p = .0074). Higher levels of MMP-1 were associated with genotypes 1G/2G+1G/1G and with LD. Other individual risk factors were independently associated with LD, and its subtypes, suggesting that the pathogenesis itself is differently manifested for each type of LD. [ABSTRACT FROM AUTHOR]

Published
2021
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37. Association of the SOD2 polymorphism (Val6Ala) and SOD activity with vaso-occlusive crisis and acute splenic sequestration in children with sickle cell anemia

Author

Farias, Isabela Cristina Cordeiro, primary, Mendonça-Belmont, Taciana Furtado, additional, Silva, Andreia Soares, additional, Do Ó, Kleyton Palmeira, additional, Ferreira, Felipe Borba, additional, Medeiros, Fernanda Silva, additional, Vasconcelos, Luydson Richardson Silva, additional, Rego, Moacyr Jesus Barreto de Melo, additional, Bezerra, Marcos Andre Cavalcanti, additional, Araujo, Aderson Silva, additional, Moura, Patricia Muniz Mendes Freire, additional, Anjos, Ana Claudia Mendonça, additional, Hatzlhofer, Betânia Lucena Domingues, additional, and Cavalcanti, Maria do Socorro Mendonça, additional

Published
2018
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38. Cognitive Dysfunction and Single Nucleotide Polymorphisms in Hepatitis C Virus-Infected Persons: A Systematic Review

Author

Carvalho, Tatiana Lins, primary, Lima, Raul Emídio, additional, Góes, Gustavo Henrique Belarmino, additional, Pereira, Lívio Amaro, additional, Fernandes, Matheus Santos de Sousa, additional, Moura, Patrícia Muniz Mendes Freire, additional, Vasconcelos, Luydson Richardson Silva, additional, and Correia, Carolina Cunha, additional

Published
2017
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39. Combined genotypes of the MBL2 gene related to low mannose-binding lectin levels are associated with vaso-occlusive events in children with sickle cell anemia

Author

Medeiros, Fernanda Silva, primary, Mendonça, Taciana Furtado de, additional, Lopes, Katiuscia Araújo de Miranda, additional, França, Laís Medeiros da Câmara, additional, Silva, Andreia Soares da, additional, Vasconcelos, Luydson Richardson Silva, additional, Oliveira, Maria do Carmo Valgueiro Costa de, additional, Anjos, Ana Cláudia Mendonça dos, additional, Hatzlhofer, Betânia Lucena Domingues, additional, Bezerra, Marcos André Cavalcanti, additional, Araújo, Aderson da Silva, additional, Moura, Patrícia, additional, and Cavalcanti, Maria do Socorro de Mendonça, additional

Published
2017
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41. TNF-αandIL-10polymorphisms increase the risk to hepatocellular carcinoma in HCV infected individuals

Author

Aroucha, Dayse Celia, primary, Carmo, Rodrigo Feliciano, additional, Vasconcelos, Luydson Richardson Silva, additional, Lima, Raul Emidio, additional, Mendonça, Taciana Furtado, additional, Arnez, Lucia Elena, additional, Cavalcanti, Maria do Socorro Mendonça, additional, Muniz, Maria Tereza Cartaxo, additional, Aroucha, Marcilio Lins, additional, Siqueira, Erika Rabelo, additional, Pereira, Luciano Beltrão, additional, Moura, Patrícia, additional, Pereira, Leila Maria Moreira Beltrão, additional, and Coêlho, Maria Rosangela, additional

Published
2016
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42. Low IL10 serum levels as key factor for predicting the sustained virological response to IFNα/ribavirin in Brazilian patients with HCV carrying IL28B CT/TT genotype

Author

Vasconcelos, Luydson Richardson Silva, primary, Moura, Patricia, additional, do Carmo, Rodrigo Feliciano, additional, Pereira, Luciano Beltrão, additional, Cavalcanti, Maria do Socorro de Mendonça, additional, Aroucha, Dayse Celia Barbosa Lins, additional, Dutra, Rosa Amália, additional, and Pereira, Leila Maria Moreira Beltrão, additional

Published
2014
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44. TNF-α and IL-10 polymorphisms increase the risk to hepatocellular carcinoma in HCV infected individuals.

Author

Aroucha, Dayse Celia, Carmo, Rodrigo Feliciano, Vasconcelos, Luydson Richardson Silva, Lima, Raul Emidio, Mendonça, Taciana Furtado, Arnez, Lucia Elena, Cavalcanti, Maria do Socorro Mendonça, Muniz, Maria Tereza Cartaxo, Aroucha, Marcilio Lins, Siqueira, Erika Rabelo, Pereira, Luciano Beltrão, Moura, Patrícia, Pereira, Leila Maria Moreira Beltrão, and Coêlho, Maria Rosangela

Abstract

Hepatitis C virus (HCV) is the major cause of hepatocellular carcinoma (HCC). The risk to develop HCC increases with the severity of liver inflammation and hepatic fibrosis. It is believed that a balance between the releases of pro- and anti-inflammatory cytokines will determine the clinical course of HCV and the risk to develop HCC. The inteleukin-10 (IL-10) and the tumor necrosis factor alpha (TNF-α) play key roles in the Th1 and Th2 balance during the inflammatory response against HCV. The aim of the present study was to investigate the association between polymorphisms in TNF-α -308 G>A (rs1800629), IL-10 -1082 G>A (rs1800896) and -819/-592 (rs1800871/rs1800872) with HCC risk in individuals with HCV. The present study evaluated 388 chronic HCV patients. Polymorphisms were determined by real-time PCR. Diplotypes associated with low IL-10 production and the TNF-α GG genotype were significantly associated with HCC occurrence after multivariate logistic regression analysis ( P = 0.027 and P = 0.029, respectively). Additionally, the IL-10 -819 (-592) TT (AA) genotype was significantly associated with multiple nodules and HCC severity according to BCLC staging ( P = 0.044 and P = 0.025, respectively). Patients carrying low production haplotypes of IL-10 and the TNF-α GG genotype have higher risk to develop HCC. J. Med. Virol. 88:1587-1595, 2016. © 2016 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Published
2016
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45. Plasma myeloperoxidase levels correlate with hepatocellular carcinoma in chronic hepatitis C

Author

do Carmo, Rodrigo Feliciano, primary, de Almeida, Débora Bezerra, additional, Aroucha, Dayse Célia Barbosa Lins, additional, Vasconcelos, Luydson Richardson Silva, additional, de Moraes, Adriano Claudio Pereira, additional, de Mendonça Cavalcanti, Maria do Socorro, additional, de Morais, Clarice Neuenschwander Lins, additional, Pereira, Leila Maria Moreira Beltrão, additional, and Moura, Patrícia, additional

Published
2012
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47. Desenvolvimento de sistemas baseados em amplificação isotérmica em alça (LAMP) para o diagnóstico da doença de Chagas

Author

Lacerda, Sarah de Souza, Carvalho, Bruno de Melo, Melo, Fábio Lopes de, Vasconcelos, Luydson Richardson Silva, Montenegro, Rosana de Albuquerque, and Melo, Fábio Lopes de Melo

Subjects
Sensibilidade e especificidade, Chagas disease, Technique d'amplification des acides nucléiques, polymerase chain reaction, diagnostico molecular, réaction en chaîne par polymérase, la enfermedad de Chagas, Sensibilidad y especificidad, reacción en cadena de la polimerasa, diagnostic moléculaire, Doença de Chagas, Sensitivity and specificity, Diagnóstico molecular, molecular diagnosis, Técnica de Amplificação de Ácidos Nucleicos, Nucleic Acid Amplification Technique, Técnica de amplificación de ácido nucleico, Sensibilité et spécificité, La maladie de Chagas, Reação em Cadeia da Polimerase
Abstract

Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. A doença de Chagas representa um importante problema de saúde pública, principalmente na América Latina. O diagnóstico precoce durante a fase aguda é crucial, pois permite o tratamento imediato, podendo interferir no prognóstico. A técnica de amplificação isotérmica em alça (LAMP) vem demonstrando potencial, por ser sensível, específica, de fácil execução e baixo custo. O presente trabalho teve como objetivo desenvolver sistemas baseados em LAMP para o diagnóstico da doença de Chagas. Inicialmente foram avaliados dois sistemas descritos na literatura: Thekisoe et al. e Ordóñez et al. O sistema de Ordóñez et al. demonstrou elevada sensibilidade e especificidade, sendo utilizado como sistema de LAMP convencional e para o desenvolvimento de um sistema de LAMP em tempo real. O sistema de LAMP convencional foi aplicado em amostras de 77 indivíduos expostos ao surto agudo ocorrido em Ibimirim/PE e comparado ao diagnóstico parasitológico, sorológico e ao sistema de qPCR (TcSAT-IAM). Segundo critérios da Secretaria Estadual de Saúde de Pernambuco, 28 casos foram confirmados pelo critério laboratorial e 10 pelo clínico-epidemiológico. Considerando o critério laboratorial, a sensibilidade e especificidade do sistema de LAMP foi de 39,29% e 83,67%, respectivamente. Considerando o diagnóstico pelo sistema TcSAT-IAM, o sistema de LAMP apresentou sensibilidade de 60,87%, especificidade de 90,74%, acurácia de 81,82% e concordância considerada moderada. A coleta das amostras após o início do tratamento e o tempo de armazenamento representaram importantes limitações do estudo. Estes resultados demonstram a importância da coleta e armazenamento adequados das amostras e sugerem um “padrão-ouro composto”, considerando os testes preconizados em conjunto com técnicas moleculares, sendo a técnica de LAMP mais acessível para áreas de recursos limitados. Para facilitar a implementação na rotina laboratorial, foi desenvolvido um kit baseado em LAMP para o diagnóstico da doença de Chagas aguda . Chagas disease represents an important public health problem, especially in Latin America. Early diagnosis during the acute phase is crucial, as it allows for immediate treatment and may interfere with the prognosis. The Loop-mediated Isothermal Amplification (LAMP) has shown potential, as it is sensitive, specific, easy to perform and low cost. The objective of the present work was to develop LAMP-based systems for the diagnosis of Chagas disease. Initially, two systems described in the literature were evaluated: Thekisoe et al. and Ordóñez et al. The system by Ordóñez et al. showed high sensitivity and specificity, being used as a conventional LAMP system and for the development of a real-time LAMP system. The conventional LAMP system was applied to samples from 77 individuals exposed to the acute outbreak that occurred in Ibimirim/PE and compared to the parasitological and serological diagnosis and to the qPCR system (TcSAT-IAM). According to criteria of the Secretaria Estadual de Saúde de Pernambuco, 28 cases were confirmed by laboratory criteria and 10 by clinical-epidemiological criteria. Considering the laboratory criteria, the sensitivity and specificity of the LAMP system was 39.29% and 83.67%, respectively. Considering the diagnosis by the TcSAT-IAM system, the LAMP system had a sensitivity of 60.87%, specificity of 90.74%, accuracy of 81.82% and agreement considered moderate. The collection of samples after the beginning of the treatment and the storage time represented important limitations of the study. These results demonstrate the importance of proper collection and storage of samples and suggest a “compound gold standard”, considering the tests recommended in conjunction with molecular techniques, being the LAMP technique more accessible for areas with limited resources. To facilitate implementation in laboratory routine, a LAMP-based kit for the diagnosis of acute Chagas disease was developed .

Published
2021

48. Avaliação da influência dos micrornas miR-21 e miR-130a no desenvolvimento de úlceras maleolares em pacientes com anemia falciforme

Author

BATISTA, Thais Helena Chaves, BEZERRA, Marcos André Cavalcanti, ARAÚJO, Antonio Roberto Lucena de, and VASCONCELOS, Luydson Richardson Silva

Subjects
Úlceras maleolares, Anemia falciforme, Moduladores genéticos
Abstract

ARAÚJO, Antonio Roberto Lucena de, também é conhecido em citações bibliográficas por: LUCENA-ARAUJO, Antonio Roberto CNPq Na busca de novos moduladores genéticos da úlcera maleolar (UM) na anemia falciforme (AF), a análise da expressão de miR-21 e miR-130a torna-se uma abordagem interessante, uma vez que ambos regulam mecanismos relacionados com a fisiopatologia das UMs, especialmente o processo de reparo tecidual. Esses microRNAs também foram relacionados com a regulação da leptina, um hormônio pleiotrópico, que atua na cicatrização de lesões cutâneas. Diante disso, o objetivo desse estudo foi investigar a influência de miR-21 e miR-130a no desenvolvimento de UMs em pacientes com AF. Foram selecionados 60 pacientes, 40 com histórico de UM (caso) e 20 que não desenvolveram UM (Controle-HbSS). O grupo caso foi subdividido em: UM aberta (UMA), n=19 e UM fechada (UMF), n=21. Também foi analisado um grupo de 10 doadores com perfil de hemoglobina normal (Controle-HbAA). As expressões dos microRNAs foram obtidas por RT-qPCR. Os níveis séricos de leptina foram avaliados por ELISA. Houve maior expressão de ambos microRNAs no grupo UMA frente aos grupos Controle-HbSS (miR-21: Fold Change [FC]=4,12, p

Published
2019

49. Associação entre a doença arterial coronariana e polimorfismos nos genes Atractin- Like1Protein (RS 180706) e Kinesin Like Protein 6 (RS 20455)

Author

CORREIA, Augusto Ferreira, OLIVEIRA, Dinaldo Cavalcanti de, and VASCONCELOS, Luydson Richardson Silva

Subjects
Polimorfismo (Genética), Artérias coronárias, Coração – Doenças
Abstract

CNPq A doença cardiovascular (DCV) é considerada a principal causa de mortalidade em todo o mundo. Nesse sentido, a identificação de características genéticas relacionadas doença arterial coronariana (DAC) tem sido estudada. Em algumas populações a presença do polimorfismo do gene Kinesin-like protein 6 (KIF6) (rs 20455) correlaciona-se com um risco cardiovascular aumentado, porém dados da literatura são conflitantes. Postula-se que, em modelos animais, o gene Attractin-like 1 protein (ATRNL1) esteja correlacionado ao equilíbrio energético e à homeostase, entretanto não existem informações sobre a influência do polimorfismo ATRL1 (rs180706) em seres humanos. Apesar de as análises genéticas e as suas associações com a DAC serem amplamente estudadas a nível mundial, dados referentes à população brasileira são escassos. O objetivo do estudo foi avaliar as associações entre polimorfismos nos genes ATRNL1 (rs 180706) e KIF6 (rs 20455) e a doença arterial coronariana. Consistiu em um estudo transversal, prospectivo, descritivo e analítico, realizado de novembro de 2017 a junho de 2018. Foram avaliados 404 indivíduos (204 com DAC e 200 controles sadios). O percentual de homens nos grupos doença e controle foi 58,8% x 20,0% (p = 0,001), respectivamente. A média de idade foi 61,99 ± 11,2 x 38,61 ± 11,6 anos (p < 0,001) nos doentes versus controles. As variáveis clínicas mais frequentes no grupo doença foram: Hipertensão arterial sistêmica (HAS) (75,5%), Diabetes Melitus (DM) (41,2%), obesidade (23,5%), infarto agudo do miocárdio (IAM) (13,7%), dislipidemia (13,2%), angioplastia transluminal percutênea (ATC) prévia (7,8%), tabagismo (5,4%), cinecoronariografia (Cine) prévia (4,4%), acidente vascular cerebral (AVC) (3,4%) e passado de cirurgia cardíaca (3,4%). No polimorfismo ATRLN1 (rs 180706) o genótipo nos doentes foi CC (49,5%), AC (42,6%) e AA (7,8%) e nos controles: CC (37,5%), AC (48,0%) e AA (14,5%) (p = 0,018). Na análise da prevalência do alelo A (AA + AC) x CC, observou-se 62,5% x 50,5% nos grupos doença e controle respectivamente (p = 0,015). No polimorfismo KIF 6 (rs 20455) o genótipo nos doentes foi AG (50%), GG (24,5%) e AA (25,5%) e nos controles: AG (51%), GG (28,5%) e AA (20,5%). Na análise da prevalência do alelo A (AA + AG) versus GG, observou-se 75,5% x 71,5% nos grupos doença e controle respectivamente (p > 0,05). Não houve associação estatisticamente significativa entre as genótipos do polimorfismo ATRLN1 (rs 180706) e as variáveis clínicas estudadas. No polimorfismo KIF6 (RS 20455) destaca-se a comparação entre os alelos agrupados (AA + AG) x GG em relação as variáveis clínicas, sendo a prevalência de pacientes com histórico de realização prévia de Cine 2,6% x 10% (p = 0,041), sem outras associações estatisticamente significativas. Ressalta-se que esse é o primeiro estudo na literatura a descrever a associação entre os polimorfismos nos genes ATRNL1 (rs 180706) e KIF6 (rs 20455) e a doença arterial coronariana. A prevalência do genótipo AA no polimorfismo do gene ATRNL1 (rs 180706) foi menor no grupo doença, quando comparada ao grupo controle. Portanto, foi gerada a hipótese da existência de um efeito protetor desse polimorfismo no desenvolvimento da DAC. Cardiovascular disease (CVD) is considered the leading cause of mortality worldwide. In this sense, the identification of genetic characteristics related to coronary artery disease (CAD) has been studied. In some populations, the presence of Kinesin-like protein 6 (KIF6) gene polymorphism (rs 20455) correlates with an increased cardiovascular risk, but literature data are conflicting. It is postulated that, in animal models, the Attractin-like 1 protein (ATRNL1) gene is correlated to energy balance and homeostasis, however, there is no information on the influence of ATRL1 polymorphism (rs180706) in humans. Although genetic analyzes and their associations with CAD are widely studied worldwide, data on the Brazilian population are scarce. The objective of the study was to evaluate the associations between polymorphisms in ATRNL1 genes (rs 180706) and KIF6 (rs 20455) and coronary artery disease. It was a cross-sectional, prospective, descriptive and analytical study was carried out from November 2017 to June 2018. A total of 404 individuals (204 with CAD and 200 healthy controls) were evaluated. The percentage of men in the disease and control groups was 58.8% x 20.0% (p = 0.001), respectively. The mean age was 61.99 ± 11.2 x 38.61 ± 11.6 years (p 0.05). There was no statistically significant association between the genotypes of the ATRLN1 polymorphism (rs 180706) and the clinical variables studied. In the KIF6 polymorphism (RS 20455) we highlight the comparison between the grouped alleles (AA + AG) vs. GG in relation to the clinical variables, being the prevalence of patients with a prior history of Cine (2.6% x 10% p = 0.041), without other statistically significant associations. We emphasize that this is the first study in the literature to describe the association between the polymorphisms in the ATRNL1 (rs 180706) and KIF6 (rs 20455) genes and coronary artery disease. The prevalence of the AA genotype in the ATRNL1 gene polymorphism (rs 180706) was lower in the disease group, when compared to the control group. Therefore, the hypothesis of the existence of a protective effect of this polymorphism in the development of CAD was generated.

Published
2018

50. High production MBL2 polymorphisms protect against COVID-19 complications in critically ill patients: A retrospective cohort study.

Author

de Andrade LV, de Souza Sá MV, Vasconcelos B, Vasconcelos LRS, Khouri R, de Souza CDF, Armstrong ADC, and do Carmo RF

Abstract

Mannose-binding lectin (MBL) binds to SARS-CoV-2, inhibits infection of susceptible cells, and activates the complement system via the lectin pathway. In this study, we investigated the association of MBL2 polymorphisms with the risk of hospitalization and clinical worsening in patients with COVID-19. A total of 550 patients with COVID-19 were included (94 non-hospitalized and 456 hospitalized). Polymorphisms in MBL2 exon 1 (codons 52, 54 and 57) and promoter region (-550, -221, and +4) were determined by real-time PCR. MBL and complement proteins were measured by Luminex. A higher frequency of the H/H genotype and the HYPA haplotype was observed in non-hospitalized patients when compared to hospitalized. In addition, critically ill patients carrying haplotypes associated with high MBL levels (HYPA/HYPA + HYPA/LYPA + HYPA/LYQA + LYPA/LYQA + LYPA/LYPA + LYQA/LYQA + LXPA/HYPA + LXPA/LYQA + LXPA/LYPA) were protected against lower oxygen saturation levels ( P  = 0.02), use of invasive ventilation use ( P  = 0.02, OR 0.38), and shock ( P  = 0.01, OR 0.40), independent of other potential confounders adjusted by multivariate analysis. Our results suggest that variants in MBL2 associated with high MBL levels may play a protective role in the clinical course of COVID-19., Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Rodrigo Feliciano do Carmo reports financial support was provided by Foundation for Support of Science and Technology of Pernambuco State. Rodrigo Feliciano do Carmo reports financial support was provided by Coordination of Higher Education Personnel Improvement. Anderson da Costa Armstrong reports financial support was provided by Secretaria Estadual de Saúde de Pernambuco. Associate editor at Heliyon - RFC., (© 2023 The Authors. Published by Elsevier Ltd.)

Published
2023
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