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307 results on '"Vasapollo, B."'

2. The 'Preeclampsia and Hypertension Target Treatment' ('PYTT') study: a multicenter prospective study to evaluate the effectiveness of the antihypertensive therapy based on maternal hemodynamic findings

Author

Pasquo, E, Giannubilo, S, Valentini, B, Salvi, S, Rullo, R, Fruci, S, Filippi, E, Ornaghi, S, Zullino, S, Rossi, F, Farsetti, D, Martino, D, Vasapollo, B, Locatelli, A, De Santis, M, Ciavattini, A, Lanzone, A, Mecacci, F, Ferrazzi, E, Valensise, H, Ghi, T, Pasquo, Elvira di, Giannubilo, Stefano Raffaele, Valentini, Beatrice, Salvi, Silvia, Rullo, Roberta, Fruci, Stefano, Filippi, Elisa, Ornaghi, Sara, Zullino, Sara, Rossi, Francesca, Farsetti, Daniele, Martino, Daniela Denis Di, Vasapollo, Barbara, Locatelli, Anna, De Santis, Michela, Ciavattini, Andrea, Lanzone, Antonio, Mecacci, Federico, Ferrazzi, Enrico, Valensise, Hebert, Ghi, Tullio, Pasquo, E, Giannubilo, S, Valentini, B, Salvi, S, Rullo, R, Fruci, S, Filippi, E, Ornaghi, S, Zullino, S, Rossi, F, Farsetti, D, Martino, D, Vasapollo, B, Locatelli, A, De Santis, M, Ciavattini, A, Lanzone, A, Mecacci, F, Ferrazzi, E, Valensise, H, Ghi, T, Pasquo, Elvira di, Giannubilo, Stefano Raffaele, Valentini, Beatrice, Salvi, Silvia, Rullo, Roberta, Fruci, Stefano, Filippi, Elisa, Ornaghi, Sara, Zullino, Sara, Rossi, Francesca, Farsetti, Daniele, Martino, Daniela Denis Di, Vasapollo, Barbara, Locatelli, Anna, De Santis, Michela, Ciavattini, Andrea, Lanzone, Antonio, Mecacci, Federico, Ferrazzi, Enrico, Valensise, Hebert, and Ghi, Tullio

Abstract

Background: Despite major advances in the pharmacological treatment of hypertension in the non-pregnant population, treatments for hypertension in pregnancy have remained largely unchanged over the years. There is recent evidence that a more adequate control of maternal blood pressure is achieved when the first given antihypertensive drug is able to correct the underlying hemodynamic disorder of the mother beside normalizing the blood pressure values. Objective: to compare the blood pressure control in women receiving an appropriate or inappropriate antihypertensive therapy in accordance with the baseline hemodynamic findings STUDY DESIGN: prospective multicenter study including a population of women with de novo diagnosis of HDP. A noninvasive assessment of the following maternal parameters was done upon the hospital admission by means of USCOM (Ultrasound Cardiac Output Monitor) before any antihypertensive therapy was given: Cardiac Output (CO), Heart Rate (HR), Systemic Vascular Resistance (SVR), Stroke Volume (SV). The clinician who prescribed the antihypertensive therapy was blinded to the hemodynamic evaluation and based on his preferences or on the local protocols used as 1st line a vasodilator (nifedipine or alpha methyldopa) or a beta-blocker (labetalol). The 1st line pharmacological treatment was retrospectively considered hemodynamically appropriate in either of the following circumstances: 1) Women with a hypodynamic profile (defined as low cardiac output [CO≤5L/min] and/or high systemic vascular resistance [SVR≥1300 dynes*s*cm]) who were administered oral nifedipine or alpha methyldopa. 2) Women with a hyperdynamic profile (defined as normal or high cardiac output [CO >5 L/min] and/or low systemic vascular resistances [SVR<1300 dynes*s*cm-]) who were administered oral labetalol. The primary outcome of the study was to compare the occurrence of severe hypertension between the women who were found to be treated with a hemodynamically appropriate or

Published
2024

18. OC19.08: Effectiveness of the antihypertensive therapy based on maternal hemodynamic findings in women with HDP: a multicentre prospective study.

Author

Taverna, M., di Pasquo, E., Giannubilo, S., Valentini, B., Salvi, S., Rullo, R., Fruci, S., Filippi, E., Ornaghi, S., Zullino, S., Farsetti, D., Di Martino, D.D., Vasapollo, B., Locatelli, A., Ciavattini, A., de Santis, M., Rossi, F., Lanzone, A., Mecacci, F., and Ferrazzi, E.

Subjects
VASCULAR resistance, CARDIAC output, BLOOD pressure, ANTIHYPERTENSIVE agents, HEART beat
Abstract

This article, titled "OC19.08: Effectiveness of the antihypertensive therapy based on maternal hemodynamic findings in women with HDP: a multicentre prospective study," discusses a study that aimed to compare the effectiveness of appropriate and inappropriate antihypertensive therapy in women with hypertensive disorders of pregnancy (HDP). The study included 152 women and assessed their hemodynamic profile before prescribing antihypertensive therapy. The results showed that women who received appropriate therapy had a lower occurrence of severe hypertension and were more likely to achieve target blood pressure values within 48-72 hours compared to those who received inappropriate therapy. The study suggests that considering the maternal hemodynamic profile when prescribing antihypertensive therapy can lead to better outcomes for women with HDP. [Extracted from the article]

Published
2024
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23. VP39.04: Early/late‐IUGR treated with NO donors transdermal patches: prognostic and predictive value of maternal hemodynamic assessment at the onset of therapy

Author

Valentini, B., primary, Tiralongo, G., additional, Farsetti, D., additional, Lupoli, B., additional, Presti, D. Lo, additional, Pisani, I., additional, Gagliardi, G., additional, Pometti, F., additional, Vasapollo, B., additional, Novelli, G., additional, and Valensise, H., additional

Published
2020
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38. Effect of a nitric oxide donor on maternal hemodynamics in fetal growth restriction

Author

Tiralongo, Gm, Pisani, I, Vasapollo, B, Khalil, A, Thilaganathan, B, and Valensise, H

Subjects
UltraSonic Cardiac Output Monitor, Adult, TVR, Plasma Substitutes, Blood Pressure, Gestational Age, Administration, Cutaneous, Ultrasonography, Prenatal, fetal growth restriction, Pregnancy, USCOM, Prenatal, Birth Weight, Humans, Nitric Oxide Donors, Prospective Studies, nitric oxide donor, maternal hemodynamics, Ultrasonography, Fetal Growth Retardation, Hemodynamics, Infant, Stroke Volume, FGR, NO donor, total vascular resistance, Case-Control Studies, Female, Vascular Resistance, Cutaneous, Settore MED/40, Administration
Abstract

To evaluate the effect on maternal cardiovascular parameters of treatment with a nitric oxide (NO) donor and plasma volume expansion in pregnancies complicated by fetal growth restriction (FGR).Twenty-six pregnant women with a diagnosis of FGR were treated with transdermal patches of a NO donor and plasma volume expansion by co-administration of oral fluids. We compared the treated group to a historical control group of untreated FGR patients. Hemodynamic indices were obtained using the UltraSonic Cardiac Output Monitor system.At diagnosis, the two groups were similar in terms of maternal and hemodynamic characteristics. In the treated group, we found a significant increase in maternal cardiac output and stroke volume and a decrease in systemic vascular resistance after 2 weeks of therapy. No significant differences were found 2 weeks after diagnosis in the untreated group. The treated group delivered infants with higher birth-weight centile than did the untreated control group.The combined therapeutic approach of NO donor administration and plasma volume expansion in FGR apparently improves significantly maternal hemodynamic indices. Copyright © 2017 ISUOG. Published by John WileySons Ltd.

Published
2018

39. Restricted physical activity in pregnancy reduces maternal vascular resistance and improves fetal growth

Author

Vasapollo, B, Lo Presti, D, Gagliardi, G, Farsetti, D, Tiralongo, Gm, Pisani, I, Novelli, Gp, and Valensise, H

Subjects
Adult, Gestational Age, bed rest, Ultrasonography, Prenatal, Fetal Development, activity restriction, fetal growth, maternal echocardiography, maternal hemodynamics, total vascular resistance, Birth Weight, Case-Control Studies, Exercise, Female, Fetal Growth Retardation, Humans, Infant, Newborn, Pregnancy, Prospective Studies, Vascular Resistance, Prenatal, Ultrasonography, Infant, Newborn, Settore MED/40
Abstract

To test the efficacy of maternal activity restriction for reducing peripheral vascular resistance in normotensive pregnant women with raised total vascular resistance (TVR) and to evaluate its effect on fetal growth.This was a prospective case-control study of 30 women enrolled between 27 and 29 weeks' gestation. All patients met the following criteria: normal blood pressure before and during pregnancy, TVR between 1300 and 1400 dynes × s/cmTVR at enrolment and estimated fetal weight centile were similar in the activity-restriction group vs controls (1358 ± 26 vs 1353 ± 30 dynes × s/cmIn normotensive pregnant women with raised TVR, maternal activity restriction appears to be effective in reducing TVR and therefore enhancing fetal growth. Copyright © 2017 ISUOG. Published by John WileySons Ltd.

Published
2018

48. Preterm delivery and elevated maternal total vascular resistance: signs of suboptimal cardiovascular adaptation to pregnancy?

Author

Valensise, H, Farsetti, D, Lo Presti, D, Pisani, I, Tiralongo, Gm, Gagliardi, G, Vasapollo, B, and Novelli, Gp

Subjects
preterm labor, Adult, maternal cardiac function, systemic peripheral resistance, C-Reactive Protein, Cardiovascular Diseases, Female, Heart, Hemodynamics, Humans, Maternal Age, Obstetric Labor, Premature, Pregnancy, Premature Birth, Risk Factors, Stroke Volume, Vascular Resistance, Obstetric Labor, Settore MED/40, Premature
Abstract

To evaluate the maternal hemodynamic profile in women with a diagnosis of threatened preterm delivery (TPD) in order to understand the possible pathophysiologic mechanism leading to an increased lifetime risk for future cardiovascular disease.Patients with a diagnosis of TPD were enrolled and assessed using a non-invasive method (USCOMA total of 68 patients were enrolled and included in the analysis. The population was divided into two groups according to total vascular resistance (TVR): Group A with a TVR of ≤ 1000 dynes × s/cmWomen with a diagnosis of TPD showing TVR values of 1000 dynes × s/cm

Published
2016

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