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18 results on '"Varricchio, m. T."'

3. Predicting the total number of retrieved oocytes following double ovarian stimulation (DuoStim).

Author

Marca, A La, Donno, V, Longo, M, Greco, P, Cucinelli, F, Varricchio, M T, Listorti, I, and Greco, E

Subjects
INDUCED ovulation, OVUM, OVARIAN reserve, MENSTRUAL cycle, HUMAN in vitro fertilization, FROZEN human embryos, BLASTOCYST
Abstract

STUDY QUESTION Can anti-Müllerian hormone (AMH) help predict how many oocytes will be retrieved following double stimulation (DuoStim)? SUMMARY ANSWER A simple clinical tool can use serum AMH values to predict ovarian response following DuoStim in IVF cycles. WHAT IS ALREADY KNOWN The knowledge that multiple follicular waves arise during a single ovarian cycle has led to the introduction of unconventional ovarian stimulation protocols. The DuoStim protocol involves two successive ovarian stimulations performed during a single ovarian cycle and has been proposed as an approach for patients with poor ovarian response and for medical fertility preservation. As AMH has been used as a marker of ovarian reserve and stimulation response, the current study aimed to investigate the diagnostic performance of AMH in predicting the number of retrieved oocytes following DuoStim. STUDY DESIGN, SIZE, DURATION This is a retrospective observational study involving 116 patients who received IVF treatment from January 2021 to September 2022. PARTICIPANTS/MATERIALS, SETTING, METHODS The study was conducted at a private IVF centre. Only patients who had their AMH measured prior to treatment and had complete patient records regarding their clinical and IVF/ICSI cycle characteristics were included. The primary outcome was the correlation between AMH values and the number of oocytes retrieved following DuoStim. Parametric and non-parametric tests were used to compare baseline characteristics and outcomes. Spearman's R was used to analyse correlations between variables, while the C statistic was used to calculate the diagnostic performance of AMH. MAIN RESULTS AND THE ROLE OF CHANCE AMH levels were significantly correlated with the total number of oocytes retrieved after the DuoStim (R 0.61; CI 0.44–0.70; P  < 0.0001). The difference in the total number of oocytes retrieved between the first (median 4 oocytes, interquartile range (IQR) 2–6) and second (median 6 oocytes, IQR 3.2–8) stimulation was statistically significant (P  < 0.0001). However, there was no significant difference in the number of mature oocytes that were retrieved (median of 3 and 4 in the first and second stimulations, respectively). After the first stimulation, 68% of patients had at least one blastocyst available, while after the second stimulation, 74% did (NS). Based on linear regression, each 0.25 ng/ml increase in basal AMH corresponds to one additional oocyte recovered at the end of both stimulations (R 2: 0.32, P  < 0.0001). LIMITATIONS, REASONS FOR CAUTION The results are limited owing to the observational nature of the study and the number of participants. WIDER IMPLICATIONS OF THE FINDINGS Counselling infertile couples regarding the intermediate outcome of IVF (i.e. number of retrieved oocytes) is one of the most demanding tasks that clinicians face. To our knowledge, this is the first study that provides an easy-to-use clinical tool that enables the quantitative prediction of ovarian response following DuoStim, based on serum AMH values. STUDY FUNDING/COMPETING INTEREST(S) No external funding was obtained for this study. The authors declare no conflicts of interest. TRIAL REGISTRATION NUMBER N/A. [ABSTRACT FROM AUTHOR]

Published
2023
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4. Contribution of cryopreservation to the cumulative live birth rate: a large multicentric cycle-based data analysis from the Italian National Registry

Author

Scaravelli, G., Levi-Setti, P. E., Livi, C., La Sala, G., Ubaldi, F. M., Greco, E., Coccia, M. E., Borini, A., Revelli, A., Ricci, G., Vigiliano, V., De Luca, R., Bolli, S., Rienzi, L., Spoletini, R., Drovanti, A., Benini, F., Villani, M. T., Albricci, L., Varricchio, M. T., Basile, V., Cattoli, M., Nizzi, A., Skerk, K., Speziale, L., Fiaccavento, S., Scaravelli, G., Levi-Setti, P. E., Livi, C., La Sala, G., Ubaldi, F. M., Greco, E., Coccia, M. E., Borini, A., Revelli, A., Ricci, G., Vigiliano, V., De Luca, R., Bolli, S., and Rienzi, L.

Subjects
0301 basic medicine, medicine.medical_specialty, Cumulative delivery rate, Cryopreservation, ICSI, IVF, Live birth, National Register, MEDLINE, Reproductive medicine, Mistake, 03 medical and health sciences, 0302 clinical medicine, Genetics, Medicine, Assisted Reproduction Technologies, Genetics (clinical), 030219 obstetrics & reproductive medicine, business.industry, Published Erratum, Obstetrics and Gynecology, General Medicine, 030104 developmental biology, Reproductive Medicine, Family medicine, National registry, business, Developmental Biology
Abstract

Purpose: To estimate the contribution of cryopreservation to the cumulative live birth rate (CLBR) after law modification in Italy in the era of vitrification and freeze-all. Methods: The Italian National Registry performed a cycle-based data collection. Nine Italian IVF clinics were involved incorporating a total of 10,260 fresh cycles performed between January 2015 and April 2016 resulting in 9273 oocyte retrievals and 3266 subsequent warming cycles from the same oocyte retrievals performed up to December 2016. Mean female age was 37 ± 4.3 years. Primary outcome measure was CLBR per oocyte retrieval. Confounding factors were tested in multivariate regression analysis, and the relative impact of cryopreservation to the CLBR in different patient categories was calculated. Results: CLBR per oocyte retrieval was 32.6%, 26.5%, 18.7%, 13.0%, and 5.5% for women younger than 36, aged 36–39, 40–41, and older than 41 years, respectively. The total relative contribution of oocyte/embryo cryopreservation was 40.6% (95% CI 38.41–42.75). An association between maternal age, number of oocytes retrieved, fertilization rate, cryopreservation, and cumulative live birth was shown. When adjusted for confounders, a 2.3-fold increase was observed in the chance of live birth when cryopreservation was performed (OR 2.3; 95% CI 1.99–2.56). In high responder patients (> 15 oocytes retrieved) where freeze-all was applied in 67.6% of cycles to avoid the risk of hyper stimulation syndrome, the relative contribution of vitrification to the CLBR was 80.6%. Conclusions: Cryopreservation is essential in IVF and should always be available to patients to optimize success rates. Multicentric, cycle-based data analyses are crucial to provide infertile couples, clinicians, and regulatory bodies with accurate information on IVF effectiveness including fresh and cryopreserved cycles.

Published
2019

5. P–566 Advanced paternal age can influence aneuploidy rate in egg donation cycles with poor sperm quality

Author

Iovine, E, primary, Zazzaro, V, additional, Pirastu, G, additional, Scarselli, F, additional, Ruberti, A, additional, Paccagnini, D, additional, Colasante, A, additional, Greco, P, additional, Pristerà, A, additional, Varricchio, M T, additional, Caragia, A, additional, Greco, A, additional, Minasi, M G, additional, and Greco, E, additional

Published
2021
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7. Rescue of in vitro fertilisation cycles by human menopausal gonadotrophin in pituitary down-regulated normogonadotrophic young women characterised by a poor initial response to recombinant follicle stimulating hormone

Author

DE PLACIDO, GIUSEPPE, MOLLO A., ALVIGGI, CARLO, STRINA I., VARRICCHIO M. T., RANIERI A., COLACURCI N., TOLINO A., WILDING M., DE PLACIDO, Giuseppe, Mollo, A., Alviggi, Carlo, Strina, I., Varricchio, M. T., Ranieri, A., Colacurci, N., Tolino, A., and Wilding, M.

Published
2001

11. Reproductive (epi)genetics

Author

Lynch, C., primary, Tee, N., additional, Rouse, H., additional, Gordon, A., additional, Sati, L., additional, Zeiss, C., additional, Soygur, B., additional, Bassorgun, I., additional, Goksu, E., additional, Demir, R., additional, McGrath, J., additional, Groendahl, M. L., additional, Thuesen, L., additional, Andersen, A. N., additional, Loft, A., additional, Smitz, J., additional, Adriaenssens, T., additional, Vikesa, J., additional, Borup, R., additional, Mersy, E., additional, Kisters, N., additional, Macville, M. V. E., additional, Engelen, J. J. M., additional, Consortium, S.-E. N. N., additional, Menheere, P. P. C. A., additional, Geraedts, J. P., additional, Coumans, A. B. C., additional, Frints, S. G. M., additional, Aledani, T., additional, Assou, S., additional, Traver, S., additional, Ait-ahmed, O., additional, Dechaud, H., additional, Hamamah, S., additional, Mizutani, E., additional, Suzumori, N., additional, Sugiyama, C., additional, Hattori, Y., additional, Sato, T., additional, Ando, H., additional, Ozaki, Y., additional, Sugiura-Ogasawara, M., additional, Wissing, M., additional, Kristensen, S. G., additional, Andersen, C. Y., additional, Mikkelsen, A. L., additional, Hoest, T., additional, Velthut-Meikas, A., additional, Simm, J., additional, Metsis, M., additional, Salumets, A., additional, Palini, S., additional, Galluzzi, L., additional, De Stefani, S., additional, Primiterra, M., additional, Wells, D., additional, Magnani, M., additional, Bulletti, C., additional, Vogt, P. H., additional, Frank-Herrmann, P., additional, Bender, U., additional, Strowitzki, T., additional, Besikoglu, B., additional, Heidemann, P., additional, Wunsch, L., additional, Bettendorf, M., additional, Jelinkova, L., additional, Vilimova, S., additional, Kosarova, M., additional, Sebek, P., additional, Volemanova, E., additional, Kruzelova, M., additional, Civisova, J., additional, Svobodova, L., additional, Sobotka, V., additional, Mardesic, T., additional, van de Werken, C., additional, Santos, M. A., additional, Eleveld, C., additional, Laven, J. S. E., additional, Baart, E. B., additional, Pylyp, L. Y., additional, Spinenko, L. A., additional, Zukin, V. D., additional, Perez-Sanz, J., additional, Matorras, R., additional, Arluzea, J., additional, Bilbao, J., additional, Gonzalez-Santiago, N., additional, Yeh, N., additional, Koff, A., additional, Barlas, A., additional, Romin, Y., additional, Manova-Todorova, K., additional, Hoz, C. D. l., additional, Mauri, A. L., additional, Nascimento, A. M., additional, Vagnini, L. D., additional, Petersen, C. G., additional, Ricci, J., additional, Massaro, F. C., additional, Cavagna, M., additional, Pontes, A., additional, Oliveira, J. B. A., additional, Baruffi, R. L. R., additional, Franco, J. G., additional, Wu, E. X., additional, Ma, S., additional, Parriego, M., additional, Sole, M., additional, Boada, M., additional, Coroleu, B., additional, Veiga, A., additional, Kakourou, G., additional, Poulou, M., additional, Vrettou, C., additional, Destouni, A., additional, Traeger-Synodinos, J., additional, Kanavakis, E., additional, Yatsenko, A. N., additional, Georgiadis, A. P., additional, McGuire, M. M., additional, Zorrilla, M., additional, Bunce, K. D., additional, Peters, D., additional, Rajkovic, A., additional, Olszewska, M., additional, Kurpisz, M., additional, Gilbertson, A. Z. A., additional, Ottolini, C. S., additional, Summers, M. C., additional, Sage, K., additional, Handyside, A. H., additional, Thornhill, A. R., additional, Griffin, D. K., additional, Chung, M. K., additional, Kim, J. W., additional, Lee, J. H., additional, Jeong, H. J., additional, Kim, M. H., additional, Ryu, M. J., additional, Park, S. J., additional, Kang, H. Y., additional, Lee, H. S., additional, Zimmermann, B., additional, Banjevic, M., additional, Hill, M., additional, Lacroute, P., additional, Dodd, M., additional, Sigurjonsson, S., additional, Lau, P., additional, Prosen, D., additional, Chopra, N., additional, Ryan, A., additional, Hall, M., additional, McAdoo, S., additional, Demko, Z., additional, Levy, B., additional, Rabinowitz, M., additional, Vereczeky, A., additional, Kosa, Z. S., additional, Savay, S., additional, Csenki, M., additional, Nanassy, L., additional, Dudas, B., additional, Domotor, Z. S., additional, Debreceni, D., additional, Rossi, A., additional, Alegretti, J. R., additional, Cuzzi, J., additional, Bonavita, M., additional, Tanada, M., additional, Matunaga, P., additional, Fettback, P., additional, Rosa, M. B., additional, Maia, V., additional, Hassun, P., additional, Motta, E. L. A., additional, Piccolomini, M., additional, Gomes, C., additional, Barros, B., additional, Nicoliello, M., additional, Criscuolo, T., additional, Miyadahira, E., additional, Montjean, D., additional, Benkhalifa, M., additional, Berthaut, I., additional, Griveau, J. F., additional, Morcel, K., additional, Bashamboo, A., additional, McElreavey, K., additional, Ravel, C., additional, Rubio, C., additional, Rodrigo, L., additional, Mateu, E., additional, Mercader, A., additional, Peinado, V., additional, Buendia, P., additional, Milan, M., additional, Delgado, A., additional, Al-Asmar, N., additional, Escrich, L., additional, Campos-Galindo, I., additional, Garcia-Herrero, S., additional, Poo, M. E., additional, Mir, P., additional, Simon, C., additional, Reyes-Engel, A., additional, Cortes-Rodriguez, M., additional, Lendinez, A., additional, Perez-Nevot, B., additional, Palomares, A. R., additional, Galdon, M. R., additional, Ruberti, A., additional, Minasi, M. G., additional, Biricik, A., additional, Colasante, A., additional, Zavaglia, D., additional, Iammarrone, E., additional, Fiorentino, F., additional, Greco, E., additional, Demir, N., additional, Ozturk, S., additional, Sozen, B., additional, Morales, R., additional, Lledo, B., additional, Ortiz, J. A., additional, Ten, J., additional, Llacer, J., additional, Bernabeu, R., additional, Nagayoshi, M., additional, Tanaka, A., additional, Tanaka, I., additional, Kusunoki, H., additional, Watanabe, S., additional, Temel, S. G., additional, Beyazyurek, C., additional, Ekmekci, G. C., additional, Aybar, F., additional, Cinar, C., additional, Kahraman, S., additional, Nordqvist, S., additional, Karehed, K., additional, Akerud, H., additional, Gultomruk, M., additional, Tulay, P., additional, Findikli, N., additional, Yagmur, E., additional, Karlikaya, G., additional, Ulug, U., additional, Bahceci, M., additional, Bargallo, M. F., additional, Arevalo, M. R., additional, Salat, M. M., additional, Barbat, I. V., additional, Lopez, J. T., additional, Algam, M. E., additional, Boluda, A. B., additional, de Oya, G. C., additional, Tolmacheva, E. N., additional, Kashevarova, A. A., additional, Skryabin, N. A., additional, Lebedev, I. N., additional, Semaco, E., additional, Belo, A., additional, Riboldi, M., additional, Luz, L., additional, Nobrega, N., additional, Mazetto, R., additional, Alegretti, J. A., additional, Bibancos, M., additional, Serafini, P., additional, Neupane, J., additional, Vandewoestyne, M., additional, Heindryckx, B., additional, Deroo, T., additional, Lu, Y., additional, Ghimire, S., additional, Lierman, S., additional, Qian, C., additional, Deforce, D., additional, De Sutter, P., additional, Viloria, T., additional, Martinez-Jabaloyas, J. M., additional, Gil-Salom, M., additional, Capalbo, A., additional, Treff, N., additional, Cimadomo, D., additional, Tao, X., additional, Ferry, K., additional, Ubaldi, F. M., additional, Rienzi, L., additional, Scott, R. T., additional, Katzorke, N., additional, Vogt, H. P., additional, Hehr, A., additional, Gassner, C., additional, Paulmann, B., additional, Kowalzyk, Z., additional, Klatt, M., additional, Krauss, S., additional, Seifert, D., additional, Seifert, B., additional, Hehr, U., additional, Lobascio, M., additional, Varricchio, M. T., additional, Rubino, P., additional, Bono, S., additional, Cotarelo, R. P., additional, Spizzichino, L., additional, Colicchia, A., additional, Giannini, P., additional, Suhorutshenko, M., additional, and Rosenstein-Tamm, K., additional

Published
2013
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12. POSTER VIEWING SESSION - EMBRYOLOGY

Author

Fourati Ben Mustapha, S., primary, Khrouf, M., additional, Kacem Ben Rejeb, K., additional, Elloumi Chaabene, H., additional, Merdassi, G., additional, Wahbi, D., additional, Ben Meftah, M., additional, Zhioua, F., additional, Zhioua, A., additional, Azzarello, A., additional, Host, T., additional, Mikkelsen, A. L., additional, Theofanakis, C. P., additional, Dinopoulou, V., additional, Mavrogianni, D., additional, Partsinevelos, G. A., additional, Drakakis, P., additional, Stefanidis, K., additional, Bletsa, A., additional, Loutradis, D., additional, Rienzi, L., additional, Cobo, A., additional, Paffoni, A., additional, Scarduelli, C., additional, Capalbo, A., additional, Garrido, N., additional, Remohi, J., additional, Ragni, G., additional, Ubaldi, F. M., additional, Herrer, R., additional, Quera, M., additional, GIL, E., additional, Serna, J., additional, Grondahl, M. L., additional, Bogstad, J., additional, Agerholm, I. E., additional, Lemmen, J. G., additional, Bentin-Ley, U., additional, Lundstrom, P., additional, Kesmodel, U. S., additional, Raaschou-Jensen, M., additional, Ladelund, S., additional, Guzman, L., additional, Ortega, C., additional, Albuz, F. K., additional, Gilchrist, R. B., additional, Devroey, P., additional, Smitz, J., additional, De Vos, M., additional, Bielanska, M., additional, Leveille, M. C., additional, Borghi, E., additional, Magli, M. C., additional, Figueroa, M. J., additional, Mascaretti, G., additional, Ferraretti, A. P., additional, Gianaroli, L., additional, Szlit, E., additional, Leocata Nieto, F., additional, Maggiotto, G., additional, Arenas, G., additional, Tarducci Bonfiglio, N., additional, Ahumada, A., additional, Asch, R., additional, Sciorio, R., additional, Dayoub, N., additional, Thong, J., additional, Pickering, S., additional, Ten, J., additional, Carracedo, M. A., additional, Guerrero, J., additional, Rodriguez-Arnedo, A., additional, Llacer, J., additional, Bernabeu, R., additional, Tatone, C., additional, Heizenrieder, T., additional, Di Emidio, G., additional, Treffon, P., additional, Seidel, T., additional, Eichenlaub-Ritter, U., additional, Cortezzi, S. S., additional, Cabral, E. C., additional, Ferreira, C. R., additional, Trevisan, M. G., additional, Figueira, R. C. S., additional, Braga, D. P. A. F., additional, Eberlin, M. N., additional, Iaconelli Jr., A., additional, Borges Jr., E., additional, Zabala, A., additional, Pessino, T., additional, Blanco, L., additional, Rey Valzacchi, G., additional, Leocata, F., additional, Vanden Meerschaut, F., additional, Heindryckx, B., additional, Qian, C., additional, Deforce, D., additional, Leybaert, L., additional, De Sutter, P., additional, De las Heras, M., additional, De Pablo, J. L., additional, Navarro, B., additional, Agirregoikoa, J. A., additional, Barrenetxea, G., additional, Cruz, M., additional, Perez-Cano, I., additional, Gadea, B., additional, Herrero, J., additional, Martinez, M., additional, Roldan, M., additional, Munoz, M., additional, Pellicer, A., additional, Meseguer, M., additional, Galindo, N., additional, Scarselli, F., additional, Alviggi, E., additional, Colasante, A., additional, Minasi, M. G., additional, Rubino, P., additional, Lobascio, M., additional, Ferrero, S., additional, Litwicka, K., additional, Varricchio, M. T., additional, Giannini, P., additional, Piscitelli, P., additional, Franco, G., additional, Zavaglia, D., additional, Nagy, Z. P., additional, Greco, E., additional, Urner, F., additional, Wirthner, D., additional, Murisier, F., additional, Mock, P., additional, Germond, M., additional, Amorocho Llanos, B., additional, Calderon, G., additional, Lopez, D., additional, Fernandez, L., additional, Nicolas, M., additional, Landeras, J., additional, Finn-Sell, S. L., additional, Leandri, R., additional, Fleming, T. P., additional, Macklon, N. S., additional, Cheong, Y. C., additional, Eckert, J. J., additional, Lee, J. H., additional, Jung, Y. J., additional, Hwang, H. K., additional, Kang, A., additional, An, S. J., additional, Jung, J. Y., additional, Kwon, H. C., additional, Lee, S. J., additional, Palini, S., additional, Zolla, L., additional, De Stefani, S., additional, Scala, V., additional, D'Alessandro, A., additional, Polli, V., additional, Rocchi, P., additional, Tiezzi, A., additional, Pelosi, E., additional, Dusi, L., additional, Bulletti, C., additional, Fadini, R., additional, Lain, M., additional, Mignini Renzini, M., additional, Brambillasca, F., additional, Coticchio, G., additional, Merola, M., additional, Guglielmo, M. C., additional, Dal Canto, M., additional, Figueira, R., additional, Setti, A. S., additional, Worrilow, K. C., additional, Uzochukwu, C. D., additional, Eid, S., additional, Le Gac, S., additional, Esteves, T. C., additional, van Rossem, F., additional, van den Berg, A., additional, Boiani, M., additional, Kasapi, E., additional, Panagiotidis, Y., additional, Goudakou, M., additional, Papatheodorou, A., additional, Pasadaki, T., additional, Prapas, N., additional, Prapas, Y., additional, Vanderzwalmen, P., additional, Norasing, S., additional, Atchajaroensatit, P., additional, Tawiwong, W., additional, Thepmanee, O., additional, Saenlao, S., additional, Aojanepong, J., additional, Hunsajarupan, P., additional, Sajjachareonpong, K., additional, Punyatanasakchai, P., additional, Maneepalviratn, S., additional, Jetsawangsri, U., additional, Tejera, A., additional, Rubio, I., additional, Romero, J. L., additional, Nordhoff, V., additional, Schlatt, S., additional, Schuring, A. N., additional, Kiesel, L., additional, Kliesch, S., additional, Azambuja, R., additional, Okada, L., additional, Lazzari, V., additional, Dorfman, L., additional, Michelon, J., additional, Badalotti, M., additional, Badalotti, F., additional, Petracco, A., additional, Schwarzer, C., additional, Versieren, K., additional, De Croo, I., additional, Lierman, S., additional, De Vos, W., additional, Van den Abbeel, E., additional, Gerris, J., additional, Milacic, I., additional, Borogovac, D., additional, Veljkovic, M., additional, Arsic, B., additional, Jovic Bojovic, D., additional, Lekic, D., additional, Pavlovic, D., additional, Garalejic, E., additional, Albertini, D. F., additional, De Ponti, E., additional, Sanges, F., additional, Talevi, R., additional, Papini, L., additional, Mollo, V., additional, Rienzi, L. F., additional, Gualtieri, R., additional, Orteg, C., additional, Choi, J., additional, Lee, H., additional, Ku, S., additional, Kim, S., additional, Choi, Y., additional, Kim, J., additional, Moon, S., additional, Demilly, E., additional, Assou, S., additional, Moussaddykine, S., additional, Dechaud, H., additional, Hamamah, S., additional, Takisawa, T., additional, Doshida, M., additional, Hattori, H., additional, Nakamura, Y., additional, Kyoya, T., additional, Shibuya, Y., additional, Nakajo, Y., additional, Tasaka, A., additional, Toya, M., additional, Kyono, K., additional, Novo, S., additional, Penon, O., additional, Gomez, R., additional, Barrios, L., additional, Duch, M., additional, Santalo, J., additional, Esteve, J., additional, Nogues, C., additional, Plaza, J. A., additional, Perez-Garcia, L., additional, Ibanez, E., additional, Chavez, S., additional, Loewke, K., additional, Behr, B., additional, Reijo Pera, R., additional, Huang, S., additional, Wang, H., additional, Soong, Y., additional, Chang, C., additional, Okimura, T., additional, Kuwayama, M., additional, Mori, C., additional, Morita, M., additional, Uchiyama, K., additional, Aono, F., additional, Kato, K., additional, Takehara, Y., additional, Kato, O., additional, Minasi, M., additional, Casciani, V., additional, Arizzi, L., additional, Mencacci, C., additional, Piscitelli, C., additional, Cucinelli, F., additional, Tocci, A., additional, Wydooghe, E., additional, Vandaele, L., additional, Dewulf, J., additional, Van Soom, A., additional, Moon, J. H., additional, Son, W. Y., additional, Mahfoudh, A., additional, Henderson, S., additional, Jin, S. G., additional, Shalom-Paz, E., additional, Dahan, M., additional, Holzer, H., additional, Mahmoud, K., additional, Triki-Hmam, C., additional, Terras, K., additional, Hfaiedh, T., additional, Ben Aribia, M. H., additional, Otsubo, H., additional, Egashira, A., additional, Tanaka, K., additional, Matsuguma, T., additional, Murakami, M., additional, Murakami, K., additional, Otsuka, M., additional, Yoshioka, N., additional, Araki, Y., additional, Kuramoto, T., additional, Smit, J. G., additional, Sterrenburg, M. D., additional, Eijkemans, M. J. C., additional, Al-Inany, H. G., additional, Youssef, M. A. F. M., additional, Broekmans, F. J. M., additional, Willoughby, K., additional, DiPaolo, L., additional, Deys, L., additional, Lagunov, A., additional, Amin, S., additional, Faghih, M., additional, Hughes, E., additional, Karnis, M., additional, Ashkar, F., additional, King, W. A., additional, Neal, M. S., additional, Antonova, I., additional, Veleva, L., additional, Petkova, L., additional, Shterev, A., additional, Nogales, C., additional, Martinez, E., additional, Ariza, M., additional, Cernuda, D., additional, Gaytan, M., additional, Linan, A., additional, Guillen, A., additional, Bronet, F., additional, Cottin, V., additional, Fabian, D., additional, Allemann, F., additional, Koller, A., additional, Spira, J. C., additional, Agudo, D., additional, Martinez-Burgos, M., additional, Arnanz, A., additional, Basile, N., additional, Rodriguez, A., additional, Cho, Y. S., additional, Filioli Uranio, M., additional, Ambruosi, B., additional, Paternoster, M. S., additional, Totaro, P., additional, Sardanelli, A. M., additional, Dell'Aquila, M. E., additional, Zollner, U., additional, Hofmann, T., additional, Zollner, K. P., additional, Kovacic, B., additional, Roglic, P., additional, Vlaisavljevic, V., additional, Sole, M., additional, Boada, M., additional, Coroleu, B., additional, Veiga, A., additional, Martiny, G., additional, Molinari, M., additional, Revelli, A., additional, Chimote, N. M., additional, Chimote, M., additional, Mehta, B., additional, Chimote, N. N., additional, Sheikh, N., additional, Nath, N., additional, Mukherjee, A., additional, Rakic, K., additional, Reljic, M., additional, Ingerslev, H. J., additional, Kirkegaard, K., additional, Hindkjaer, J., additional, Agerholm, I., additional, Kitasaka, H., additional, Fukunaga, N., additional, Nagai, R., additional, Yoshimura, T., additional, Tamura, F., additional, Kitamura, K., additional, Hasegawa, N., additional, Nakayama, K., additional, Katou, M., additional, Itoi, F., additional, Asano, E., additional, Deguchi, N., additional, Ooyama, K., additional, Hashiba, Y., additional, Asada, Y., additional, Michaeli, M., additional, Rotfarb, N., additional, Karchovsky, E., additional, Ruzov, O., additional, Atamny, R., additional, Slush, K., additional, Fainaru, O., additional, Ellenbogen, A., additional, Chekuri, S., additional, Chaisrisawatsuk, T., additional, Chen, P., additional, Pangestu, M., additional, Jansen, S., additional, Catt, S., additional, Molinari, E., additional, Racca, C., additional, Ryu, C., additional, Kang, S., additional, Lee, J., additional, Chung, D., additional, Roh, S., additional, Chi, H., additional, Yokota, Y., additional, Yokota, M., additional, Yokota, H., additional, Sato, S., additional, Nakagawa, M., additional, Komatsubara, M., additional, Makita, M., additional, Oyama, K., additional, Naruse, K., additional, Kilani, S., additional, Chapman, M. G., additional, Kwik, M., additional, Chapman, M., additional, Guven, S., additional, Odaci, E., additional, Yildirim, O., additional, Kart, C., additional, Unsal, M. A., additional, Yulug, E., additional, Isachenko, E., additional, Maettner, R., additional, Strehler, E., additional, Isachenko, V., additional, Hancke, K., additional, Kreienberg, R., additional, Sterzik, K., additional, Zheng, X. Y., additional, Wang, L. N., additional, Liu, P., additional, Qiao, J., additional, Inoue, F., additional, Dashtizad, M., additional, Wahid, H., additional, Rosnina, Y., additional, Daliri, M., additional, Hajarian, H., additional, Akbarpour, M., additional, Abbas Mazni, O., additional, Knez, K., additional, Tomaevic, T., additional, Vrtacnik Bokal, E., additional, Zorn, B., additional, Virant Klun, I., additional, Koster, M., additional, Liebenthron, J., additional, Nicolov, A., additional, van der Ven, K., additional, van der Ven, H., additional, Montag, M., additional, Fayazi, M., additional, Salehnia, M., additional, Beigi Boroujeni, M., additional, Khansarinejad, B., additional, Deignan, K., additional, Emerson, G., additional, Mocanu, E., additional, Wang, J. J., additional, Andonov, M., additional, Linara, E., additional, Ahuja, K. K., additional, Nachef, S., additional, Pasqualotto, F. F., additional, Pasqualotto, E., additional, Chang, C. C., additional, Bernal, D. P., additional, Elliott, T. A., additional, Shapiro, D. B., additional, Toledo, A. A., additional, Economou, K., additional, Davies, S., additional, Argyrou, M., additional, Doriza, S., additional, Sisi, P., additional, Moschopoulou, M., additional, Karagianni, A., additional, Mendorou, C., additional, Polidoropoulos, N., additional, Papanicopoulos, C., additional, Stefanis, P., additional, Karamalegos, C., additional, Cazlaris, H., additional, Koutsilieris, M., additional, Mastrominas, M., additional, Gotts, S., additional, Doshi, A., additional, Harper, J., additional, Serhal, P., additional, Borini, A., additional, Guzeloglu-Kayisli, O., additional, Bianchi, V., additional, Seli, E., additional, Lappi, M., additional, Bonu, M. A., additional, Mizuta, S., additional, Hashimoto, H., additional, Kuroda, Y., additional, Matsumoto, Y., additional, Mizusawa, Y., additional, Ogata, S., additional, Yamada, S., additional, Kokeguchi, S., additional, Noda, Y., additional, Shiotani, M., additional, Stojkovic, M., additional, Ilic, M., additional, Markovic, N., additional, Stojkovic, P., additional, Feng, G., additional, Zhang, B., additional, Zhou, H., additional, Zhou, L., additional, Gan, X., additional, Qin, X., additional, Shu, J., additional, Wu, F., additional, Molina Botella, I., additional, Lazaro Ibanez, E., additional, Debon Aucejo, A., additional, Pertusa, J., additional, Fernandez Colom, P. J., additional, Li, C., additional, Zhang, Y., additional, Cui, Y., additional, Zhao, H., additional, Liu, J., additional, Oliveira, J. B. A., additional, Petersen, C. G., additional, Mauri, A. L., additional, Massaro, F. C., additional, Silva, L. F. I., additional, Ricci, J., additional, Cavagna, M., additional, Pontes, A., additional, Vagnini, L. D., additional, Baruffi, R. L. R., additional, Franco Jr., J. G., additional, Felipe, V., additional, Vilela, M., additional, Tiveron, M., additional, Lombardi, C., additional, Viglierchio, M. I., additional, Marconi, G., additional, Rawe, V., additional, Wale, P. L., additional, Gardner, D. K., additional, Nakagawa, K., additional, Sugiyama, R., additional, Nishi, Y., additional, Kuribayashi, Y., additional, Jyuen, H., additional, Yamashiro, E., additional, Shirai, A., additional, Inoue, M., additional, Hovatta, O., additional, Tohonen, V., additional, Inzunza, J., additional, Parmegiani, L., additional, Cognigni, G. E., additional, Bernardi, S., additional, Ciampaglia, W., additional, Infante, F. E., additional, Tabarelli de Fatis, C., additional, Pocognoli, P., additional, Arnone, A., additional, Maccarini, A. M., additional, Troilo, E., additional, Filicori, M., additional, Radwan, P., additional, Polac, I., additional, Borowiecka, M., additional, Bijak, M., additional, and Radwan, M., additional

Published
2011
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13. POSTER VIEWING SESSION - ANDROLOGY

Author

Dul, E. C., primary, van Ravenswaaij-Arts, C. M. A., additional, Groen, H., additional, van Echten-Arends, J., additional, Land, J. A., additional, Tyulenev, Y., additional, Naumenko, V., additional, Kurilo, L., additional, Shileiko, L., additional, Segal, A., additional, Klimova, R., additional, Kushch, A., additional, Ribas-Maynou, J., additional, Garcia-Peiro, A., additional, Abad, C., additional, Amengual, M. J., additional, Benet, J., additional, Navarro, J., additional, Colasante, A., additional, Lobascio, A. M., additional, Scarselli, F., additional, Minasi, M. G., additional, Alviggi, E., additional, Rubino, P., additional, Casciani, V., additional, Pena, R., additional, Varricchio, M. T., additional, Litwicka, K., additional, Ferrero, S., additional, Zavaglia, D., additional, Franco, G., additional, Nagy, Z. P., additional, Greco, E., additional, Romany, L., additional, Meseguer, M., additional, Garcia-Herrero, S., additional, Pellicer, A., additional, Garrido, N., additional, Dam, A., additional, Pijnenburg, A., additional, Hendriks, J. C., additional, Westphal, J. R., additional, Ramos, L., additional, Kremer, J. A. M., additional, Eertmans, F., additional, Bogaert, V., additional, Puype, B., additional, Geisler, W., additional, Clusmann, C., additional, Klopsch, I., additional, Strowitzki, T., additional, Eggert-Kruse, W., additional, Maettner, R., additional, Isachenko, E., additional, Isachenko, V., additional, Strehler, E., additional, Sterzik, K., additional, Band, G., additional, Madgar, I., additional, Brietbart, H., additional, Naor, Z., additional, Cunha-Filho, J. S., additional, Souza, C. A., additional, Krebs, V. G., additional, Santos, K. D., additional, Koff, W. J., additional, Stein, A., additional, Hammoud, I., additional, Albert, M., additional, Bergere, M., additional, Bailly, M., additional, Boitrelle, F., additional, Vialard, F., additional, Wainer, R., additional, Izard, V., additional, Selva, J., additional, Cohen - Bacrie, P., additional, Belloc, S., additional, de mouzon, J., additional, Cohen-Bacrie, M., additional, Alvarez, S., additional, Junca, A. M., additional, Dumont, M., additional, Douard, S., additional, Prisant, N., additional, Tomita, K., additional, Hashimoto, S., additional, Akamatsu, Y., additional, Satoh, M., additional, Mori, R., additional, Inoue, T., additional, Ohnishi, Y., additional, Ito, K., additional, Nakaoka, Y., additional, Morimoto, Y., additional, Smith, V. J. H., additional, Ahuja, K. K., additional, Atig, F., additional, Raffa, M., additional, Sfar, M. T., additional, Saad, A., additional, Ajina, M., additional, Braga, D. P. A. F., additional, Halpern, G., additional, Figueira, R. C. S., additional, Setti, A. S., additional, Iaconelli Jr., A., additional, Borges Jr., E., additional, Medeiros, G. S., additional, Pasqualotto, E. B., additional, Pasqualotto, F. F., additional, Nadalini, M., additional, Tarozzi, N., additional, Di Santo, M., additional, Borini, A., additional, Lopez-Fernandez, C., additional, Arroyo, F., additional, Caballero, P., additional, Nunez-Calonge, R., additional, Fernandez, J. L., additional, Gosalvez, J., additional, Gosalbez, A., additional, Cortes, S., additional, Zikopoulos, K., additional, Lazaros, L., additional, Vartholomatos, G., additional, Kaponis, A., additional, Makrydimas, G., additional, Plachouras, N., additional, Sofikitis, N., additional, Kalantaridou, S., additional, Hatzi, E., additional, Georgiou, I., additional, de Mouzon, J., additional, Amar, E., additional, Cohen-Bacrie, P., additional, Vuillaume, M. L., additional, Brugnon, F., additional, Artonne, C., additional, Janny, L., additional, Pons-Rejraji, H., additional, Fedder, J., additional, Bosco, L., additional, Ruvolo, G., additional, Bruccoleri, A. M., additional, Manno, M., additional, Roccheri, M. C., additional, Cittadini, E., additional, Bochev, I., additional, Gavrilov, P., additional, Kyurkchiev, S., additional, Shterev, A., additional, Carlomagno, G., additional, Colone, M., additional, Condorelli, R. A., additional, Stringaro, A., additional, Calogero, A. E., additional, Zakova, J., additional, Kralikova, M., additional, Crha, I., additional, Ventruba, P., additional, Melounova, J., additional, Matejovicova, M., additional, Vodova, M., additional, Lousova, E., additional, Sanchez Toledo, M., additional, Alvarez LLeo, C., additional, Garcia Garrido, C., additional, Resta Serra, M., additional, Belmonte Andujar, L. L., additional, Gonzalez de Merlo, G., additional, Pohanka, M., additional, Huser, M., additional, Amiri, I., additional, Karimi, J., additional, Goodarzi, M. T., additional, Tavilani, H., additional, Filannino, A., additional, Magli, M. C., additional, Boudjema, E., additional, Crippa, A., additional, Ferraretti, A. P., additional, Gianaroli, L., additional, Robles, F., additional, Huang, H., additional, Yao, D. J., additional, Huang, H. J., additional, Li, J. R., additional, Fan, S. K., additional, Wang, M. L., additional, Yung-Kuei, S., additional, Amer, S., additional, Mahran, A., additional, Darne, J., additional, Shaw, R., additional, Borghi, E., additional, Cetera, C., additional, Shukla, U., additional, Ogutu, D., additional, Deval, B., additional, Jansa, M., additional, Savvas, M., additional, Narvekar, N., additional, Houska, P., additional, Dackland, A. L., additional, Bjorndahl, L., additional, Kvist, U., additional, Muzii, L., additional, Barboni, B., additional, Samanta, L., additional, Kar, S., additional, Yakovenko, S. A., additional, Troshina, M. N., additional, Rutman, B. K., additional, Dyakonov, S. A., additional, Holmes, E., additional, Feijo, C., additional, Verza Junior, S., additional, Esteves, S. C., additional, Berta, C. L., additional, Caille, A. M., additional, Ghersevich, S. A., additional, Zumoffen, C., additional, Munuce, M. J., additional, San Celestino, M., additional, Agudo, D., additional, Alonso, M., additional, Sanjurjo, P., additional, Becerra, D., additional, Bronet, F., additional, Garcia-Velasco, J. A., additional, Pacheco, A., additional, Lafuente, R., additional, Lopez, G., additional, Checa, M. A., additional, Carreras, R., additional, Brassesco, M., additional, Oneta, M., additional, Savasi, V., additional, Parrilla, B., additional, Guarneri, D., additional, Laureti, A., additional, Pagano, F., additional, Cetin, I., additional, Ekwurtzel, E., additional, Morgante, G., additional, Piomboni, P., additional, Stendardi, A., additional, Serafini, F., additional, De Leo, V., additional, Focarelli, R., additional, Benkhalifa, M., additional, De Mouzon, J., additional, Entezami, F., additional, Junca, A., additional, De Mouzon, J. J., additional, Mangiarini, A., additional, Capitanio, E., additional, Paffoni, A., additional, Restelli, L., additional, Guarneri, C., additional, Scarduelli, C., additional, Ragni, G., additional, Harrison, K., additional, Irving, J., additional, Martin, N., additional, Sherrin, D., additional, Yazdani, A., additional, Almeida, C., additional, Correia, S., additional, Rocha, E., additional, Alves, A., additional, Cunha, M., additional, Ferraz, L., additional, Silva, S., additional, Sousa, M., additional, Barros, A., additional, Perdrix, A., additional, Travers, A., additional, Milazzo, J. P., additional, Clatot, F., additional, Mousset-Simeon, N., additional, Mace, B., additional, Rives, N., additional, Clarke, H. S., additional, Callow, A., additional, Saxton, D., additional, Pacey, A. A., additional, Sapir, O., additional, Oron, G., additional, Ben-Haroush, A., additional, Garor, R., additional, Feldberg, D., additional, Pinkas, H., additional, Wertheimer, A., additional, Fisch, B., additional, Palacios, E., additional, Gonzalvo, M. C., additional, Clavero, A., additional, Ramirez, J. P., additional, Rosales, A., additional, Mozas, J., additional, Castilla, J. A., additional, Mugica, J., additional, Ramon, O., additional, Valdivia, A., additional, Exposito, A., additional, Casis, L., additional, Matorras, R., additional, Bongers, R., additional, Gottardo, F., additional, Zitzmann, M., additional, Kliesch, S., additional, Cordes, T., additional, Kamischke, A., additional, Schultze-Mosgau, A., additional, Buendgen, N., additional, Diedrich, K., additional, Griesinger, G., additional, Crisol, L., additional, Aspichueta, F., additional, Hernandez, M. L., additional, Ruiz-Sanz, J. I., additional, Mendoza, R., additional, Sanchez-Tusie, A. A., additional, Bermudez, A., additional, Lopez, P., additional, Churchill, G. C., additional, Trevino, C. L., additional, Maldonado, I., additional, and Dabbah, J., additional

Published
2011
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14. SELECTED ORAL COMMUNICATION SESSION, SESSION 63: PREIMPLANTATION GENETICS Wednesday 6 July 2011 10:00 - 11:45

Author

Colls, P., primary, Fischer, J., additional, Escudero, T., additional, Ketterson, K., additional, Harton, G., additional, Munne, S., additional, Capalbo, A., additional, Fiorentino, F., additional, Maggiulli, R., additional, Romano, S., additional, Borsatti, A., additional, Joseph, A., additional, Spizzichino, L., additional, Bono, S., additional, Biricik, A., additional, Colamaria, S., additional, Ubaldi, M. F., additional, Rienzi, L. F., additional, Rubino, P., additional, Arizzi, L., additional, Minasi, M. G., additional, Pena, R., additional, Scarselli, F., additional, Casciani, V., additional, Colasante, A., additional, Ferrero, S., additional, Litwicka, K., additional, Varricchio, M. T., additional, Cucinelli, F., additional, Nagy, Z. P., additional, Greco, E., additional, Beyazyurek, C., additional, Ekmekci, C. G., additional, Tac, H. A., additional, Ajredin, N., additional, Yelke, H., additional, Kahraman, S., additional, De Rademaeker, M., additional, Moutou, C., additional, Van Rij, M., additional, Dreesen, J., additional, De Rycke, M., additional, Liebaers, I., additional, Viville, S., additional, Geraedts, J., additional, De Die, C., additional, Wells, D., additional, Fragouli, E., additional, Colls, P., additional, Alfarawati, S., additional, Kashevarova, A., additional, Tolmacheva, E., additional, Sukhanova, N., additional, and Lebedev, I., additional

Published
2011
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15. Rescue of IVF cycles by HMG in pituitary down-regulated normogonadotrophic young women characterized by a poor initial response to recombinant FSH.

Author

De Placido, Giuseppe, Mollo, Antonio, Alviggi, Carlo, Strina, Ida, Varricchio, Maria Teresa, Ranieri, Antonio, Colacurci, Nicola, Tolino, Achille, Wilding, Martin, De Placido, G, Mollo, A, Alviggi, C, Strina, I, Varricchio, M T, Ranieri, A, Colacurci, N, Tolino, A, and Wilding, M

Abstract

Background: The aim of this study was to investigate the effects of adding human menopausal gonadotrophin (HMG) during controlled ovarian stimulation in normoovulatory normogonadotrophic patients showing an initial suboptimal response to a standardized long protocol therapy with recombinant FSH (rFSH) (300 IU/day).Methods: A total of 43 such patients were randomized in two groups. In Group A, 150 IU rFSH was substituted by 150 IU HMG after day 8 of stimulation. The stimulation protocol of Group B involved a simple increase of the daily rFSH dose to 375 IU after day 8. A total of 40 BMI and age matched patients with an optimal ovarian response formed the control group (Group C).Results: The mean Group A serum concentration of oestradiol on the day of HCG administration and average number of oocytes retrieved were significantly higher than Group B (P < 0.001) and equivalent to Group C. A total of 10 pregnancies (50%) in Group A, 8 (34.8%) in Group B and 19 (47.5%) in the control group were achieved.Conclusions: The data suggest that LH supplementation improves the ovarian outcome in patients characterized by an inadequate initial response to rFSH therapy in a long protocol. [ABSTRACT FROM AUTHOR]

Published
2001
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16. Effect of low-dose aspirin and prednisone administered after ovum pick-up on implantation and abortion rates in women with no auto-immune disorders undergoing ICSI: A prospective randomised trial

Author

Antonio MOLLO, Strina, Ida, Alviggi, Carlo, Varricchio, M. T., D Uva, M., Cadente, C., Carravetta, C., Alviggi, E., Ranieri, A., Lubrano Lo Bianco, C., Amato, V., Borrelli, M. L., Conforti, S., Placido, Giuseppe, Mollo, Antonio, Strina, Ida, Alviggi, Carlo, Varricchio, M. T., D'Uva, M., Cadente, C., Carravetta, C., Alviggi, E., Ranieri, A., Lubrano Lo Bianco, C., Amato, V., Borrelli, M. L., Conforti, S., and DE PLACIDO, Giuseppe

17. Effects of recombinant LH (rLH) supplementation during controlled ovarian hyperstimulation (COH) in normogonadotrophic women with an initial inadequate response to recombinant FSH (rFSH) after pituitary downregulation

Author

Salvatore Conforti, G. De Placido, Maria Teresa Varricchio, A. Ranieri, Antonio Mollo, A. L. Borrelli, Carlo Alviggi, Ida Strina, Erminia Alviggi, Martin Wilding, DE PLACIDO, Giuseppe, Alviggi, Carlo, Mollo, Antonio, Strina, Ida, Ranieri, A, Alviggi, E, Wilding, M, Varricchio, Mt, Borrelli, Al, Conforti, Salvatore, Mollo, A., Strina, I., Ranieri, A., Alviggi, E., Wilding, M., Varricchio, M. T., Borrelli, A. L., and Conforti, S.

Subjects
Adult, medicine.medical_specialty, Pituitary gland, medicine.drug_class, Endocrinology, Diabetes and Metabolism, Controlled ovarian hyperstimulation, Fertilization in Vitro, Biology, Group B, Drug Administration Schedule, law.invention, Follicle-stimulating hormone, Endocrinology, Randomized controlled trial, Ovulation Induction, law, Internal medicine, medicine, Humans, Prospective Studies, Prospective cohort study, Ovarian Function Tests, Analysis of Variance, Luteinizing Hormone, Recombinant Proteins, medicine.anatomical_structure, Female, Gonadotropin, Follicle Stimulating Hormone, Luteinizing hormone
Abstract

This study was aimed to evaluate the effect of different recombinant LH (rLH) doses on the ovarian outcome of normogonadotrophic women with an initial inadequate response to recombinant FSH (rFSH) after pituitary downregulation. METHODS: Only women undergoing a 'long protocol' with a GnRH-agonist followed by rFSH administration were enrolled. On the eighth day of stimulation, 46 patients with serum E2 levels < 180 pg/ml and with no follicle > 10 mm were randomized in two groups to receive a supplementation with a daily rLH dose of 75 (group A) or 150 IU (group B), respectively. Forty-six normal responders continuing their monotherapy with rFSH formed the control group (C). RESULTS: The mean number of oocytes retrieved and the percentage of mature oocytes in the group B (9.65 +/- 2.16, 79.0%) were comparable with those observed in the group C (10.65 +/- 2.8, 82.5%) and significantly higher when compared with the group A (6.39 +/- 1.53, 65.7%). The mean number of ampoules of rLH was significantly higher in the group B (14.4 +/- 2.0 vs. 9.65 +/- 1.1), whereas these patients received a significantly lower mean number of rFSH ampoules (44.6 +/- 7.4 vs. 36.1 +/- 3.8). Seven (30.4%), 9 (39.1%) and 22 (47.8%) pregnancies were achieved in the groups A, B and C, respectively. CONCLUSIONS: These results suggest that patients with initial inadequate responses to rFSH after pituitary downregulation benefit from the addition of a daily dose of 150 IU of rLH, starting from the eighth day of stimulation.

Published
2004

18. Recombinant follicle stimulating hormone is effective in poor responders to highly purified follicle stimulating hormone.

Author

De Placido G, Alviggi C, Mollo A, Strina I, Varricchio MT, and Molis M

Subjects
Estradiol blood, Female, Follicle Stimulating Hormone administration & dosage, Humans, Pregnancy, Recombinant Proteins therapeutic use, Triptorelin Pamoate administration & dosage, Triptorelin Pamoate therapeutic use, Fertilization in Vitro, Follicle Stimulating Hormone therapeutic use, Ovulation Induction
Abstract

Ovarian stimulation in cases of poor ovarian responsiveness is an important challenge in in-vitro fertilization (IVF) programmes. Despite improvements in oocyte number and quality, an ideal ovarian stimulation strategy has yet to be defined. Here, the results of ovarian stimulation with recombinant follicle stimulating hormone (rFSH) in 28 poor responders to highly purified FSH (FSH-HP) with high basal concentrations of FSH are reported. The protocols used on the FSH-HP and rFSH cycles were identical with the sole exception of the FSH preparation: triptorelin 0.1 mg/day (gonadotrophin-releasing hormone, GnRH-agonist short protocol) and the starting FSH dose of 300 IU/day were administered from day 2 of the menstrual cycle. Ovarian outcome was classified as 'normal', 'intermediate' and 'poor', depending on the number of mature oocytes retrieved and the peak serum oestradiol concentration. Nine of the 28 subjects had an intermediate ovarian response to re-stimulation with rFSH. In the 26 patients who received human chorionic gonadotrophin on both cycles, re-stimulation resulted in a significant increase (P < 0.05) in the mean number of mature oocytes (2.4 +/- 1.4 versus 1.7 +/- 0.8), mean peak oestradiol concentration (606 +/- 252 versus 443 +/- 32 pg/ml) and fertilization rate (73.0 versus 53.3%). Four pregnancies were achieved. It is concluded that rFSH in a GnRH-agonist short protocol improves the ovarian outcome in poor responders to FSH-HP with high basal concentrations of FSH.

Published
2000
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