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4. Association Between Educational Level and Asthma: Potential Mediation by Lifestyle Profiles in the French Nutrinet-santé Cohort

Author

Bédard, A., primary, Guillien, A., additional, Dumas, O., additional, Allegre, J., additional, Arnault, N., additional, Bochaton, A., additional, Druesne-Pecollo, N., additional, Dumay, D., additional, Fezeu, L., additional, Hercberg, S., additional, Le Moual, N., additional, Pilkington, H., additional, Rican, S., additional, Sit, G., additional, Szabo, F., additional, Touvier, M., additional, Galan, P., additional, Feuillet, T., additional, Siroux, V., additional, and Varraso, R., additional

Published
2023
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5. Operational definition of Active and Healthy Ageing (AHA): A conceptual framework

Author

Bousquet, Jean, Kuh, D., Bewick, M., Standberg, T., Farrell, J., Pengelly, R., Joel, M.E., Rodriguez Mañas, L., Mercier, J., Bringer, J., Camuzat, T., Bourret, R., Bedbrook, A., Kowalski, M.L., Samolinski, B., Bonini, S., Brayne, C., Michel, J.P., Venne, J., Viriot-Durandal, P., Alonso, J., Avignon, A., Ben-Shlomo, Y., Bousquet, P.J., Combe, B., Cooper, R., Hardy, R., Iaccarino, G., Keil, T., Kesse-Guyot, E., Momas, I., Ritchie, K., Robine, J.M., Thijs, C., Tischer, C., Vellas, B., Zaidi, A., Alonso, F., Andersen Ranberg, K., Andreeva, V., Ankri, J., Arnavielhe, S., Arshad, H., Augé, P., Berr, C., Bertone, P., Blain, H., Blasimme, A., Buijs, G.J., Caimmi, D., Carriazo, A., Cesario, A., Coletta, J., Cosco, T., Criton, M., Cuisinier, F., Demoly, P., Fernandez-Nocelo, S., Fougère, B., Garcia-Aymerich, J., Goldberg, M., Guldemond, N., Gutter, Z., Harman, D., Hendry, A., Heve, D., Illario, M., Jeande, C., Krauss-Etschmann, S., Krys, O., Kula, D., Laune, D., Lehmann, S., Maier, D., Malva, J., Matignon, P., Melen, E., Mercier, G., Moda, G., Nizinkska, A., Nogues, M., O'Neill, M., Pelissier, J.Y., Poethig, D., Porta, D., Postma, D., Puisieux, F., Richards, M., Robalo-Cordeiro, C., Romano, V., Roubille, F., Schulz, H., Scott, A., Senesse, P., Slagter, S., Smit, H.A., Somekh, D., Stafford, M., Suanzes, J., Todo-Bom, A., Touchon, J., Traver-Salcedo, V., Van Beurden, M., Varraso, R., Vergara, I., Villalba-Mora, E., Wilson, N., Wouters, E., and Zins, M.

Published
2015
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6. Facteurs génétiques et environnementaux de l’asthme et de l’allergie : synthèse des résultats de l’étude EGEA

Author

Bouzigon, E., Nadif, R., Le Moual, N., Dizier, M.-H., Aschard, H., Boudier, A., Bousquet, J., Chanoine, S., Donnay, C., Dumas, O., Gormand, F., Jacquemin, B., Just, J., Margaritte-Jeannin, P., Matran, R., Pison, C., Rage, E., Rava, M., Sarnowski, C., Smit, L.A.M., Temam, S., Varraso, R., Vignoud, L., Lathrop, M., Pin, I., Demenais, F., Kauffmann, F., and Siroux, V.

Published
2015
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14. Combined Effect of Socioeconomic, Environmental, and Lifestyle Factors on Asthma: An Exposome Study in the French Nutrinet-Santé Cohort

Author

Guillien, A., primary, Bédard, A., additional, Dumas, O., additional, Allegre, J., additional, Arnault, N., additional, Bochaton, A., additional, Druesne-Pecollo, N., additional, Dumay, D., additional, Fezeu, L., additional, Hercberg, S., additional, Le Moual, N., additional, Pilkington, H., additional, Rican, S., additional, Sit, G., additional, Szabo, F., additional, Touvier, M., additional, Galan, P., additional, Feuillet, T., additional, Varraso, R., additional, and Siroux, V., additional

Published
2022
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15. Long-term exposure to low-level air pollution and incidence of asthma: The ELAPSE project

Author

Liu, S. Jørgensen, J.T. Ljungman, P. Pershagen, G. Bellander, T. Leander, K. Magnusson, P.K.E. Rizzuto, D. Hvidtfeldt, U.A. Raaschou-Nielsen, O. Wolf, K. Hoffmann, B. Brunekreef, B. Strak, M. Chen, J. Mehta, A. Atkinson, R.W. Bauwelinck, M. Varraso, R. Boutron-Ruault, M.-C. Brandt, J. Cesaroni, G. Forastiere, F. Fecht, D. Gulliver, J. Hertel, O. de Hoogh, K. Janssen, N.A.H. Katsouyanni, K. Ketzel, M. Klompmaker, J.O. Nagel, G. Oftedal, B. Peters, A. Tjønneland, A. Rodopoulou, S.P. Samoli, E. Kristoffersen, D.T. Sigsgaard, T. Stafoggia, M. Vienneau, D. Weinmayr, G. Hoek, G. Andersen, Z.J.

Abstract

Background: Long-term exposure to ambient air pollution has been linked to childhood-onset asthma, although evidence is still insufficient. Within the multicentre project Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE), we examined the associations of long-term exposures to particulate matter with a diameter

Published
2021

16. Long-term exposure to low-level air pollution and incidence of chronic obstructive pulmonary disease: The ELAPSE project

Author

Liu, S. Jørgensen, J.T. Ljungman, P. Pershagen, G. Bellander, T. Leander, K. Magnusson, P.K.E. Rizzuto, D. Hvidtfeldt, U.A. Raaschou-Nielsen, O. Wolf, K. Hoffmann, B. Brunekreef, B. Strak, M. Chen, J. Mehta, A. Atkinson, R.W. Bauwelinck, M. Varraso, R. Boutron-Ruault, M.-C. Brandt, J. Cesaroni, G. Forastiere, F. Fecht, D. Gulliver, J. Hertel, O. de Hoogh, K. Janssen, N.A.H. Katsouyanni, K. Ketzel, M. Klompmaker, J.O. Nagel, G. Oftedal, B. Peters, A. Tjønneland, A. Rodopoulou, S.P. Samoli, E. Bekkevold, T. Sigsgaard, T. Stafoggia, M. Vienneau, D. Weinmayr, G. Hoek, G. Andersen, Z.J.

Subjects
complex mixtures
Abstract

Background: Air pollution has been suggested as a risk factor for chronic obstructive pulmonary disease (COPD), but evidence is sparse and inconsistent. Objectives: We examined the association between long-term exposure to low-level air pollution and COPD incidence. Methods: Within the ‘Effects of Low-Level Air Pollution: A Study in Europe’ (ELAPSE) study, we pooled data from three cohorts, from Denmark and Sweden, with information on COPD hospital discharge diagnoses. Hybrid land use regression models were used to estimate annual mean concentrations of particulate matter with a diameter < 2.5 µm (PM2.5), nitrogen dioxide (NO2), and black carbon (BC) in 2010 at participants’ baseline residential addresses, which were analysed in relation to COPD incidence using Cox proportional hazards models. Results: Of 98,058 participants, 4,928 developed COPD during 16.6 years mean follow-up. The adjusted hazard ratios (HRs) and 95% confidence intervals for associations with COPD incidence were 1.17 (1.06, 1.29) per 5 µg/m3 for PM2.5, 1.11 (1.06, 1.16) per 10 µg/m3 for NO2, and 1.11 (1.06, 1.15) per 0.5 10−5m−1 for BC. Associations persisted in subset participants with PM2.5 or NO2 levels below current EU and US limit values and WHO guidelines, with no evidence for a threshold. HRs for NO2 and BC remained unchanged in two-pollutant models with PM2.5, whereas the HR for PM2.5 was attenuated to unity with NO2 or BC. Conclusions: Long-term exposure to low-level air pollution is associated with the development of COPD, even below current EU and US limit values and possibly WHO guidelines. Traffic-related pollutants NO2 and BC may be the most relevant. © 2020

Published
2021

19. MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine

Author

Bousquet, J., Anto, J., Auffray, C., Akdis, M., Cambon-Thomsen, A., Keil, T., Haahtela, T., Lambrecht, B. N., Postma, D. S., Sunyer, J., Valenta, R., Akdis, C. A., Annesi-Maesano, I., Arno, A., Bachert, C., Ballester, F., Basagana, X., Baumgartner, U., Bindslev-Jensen, C., Brunekreef, B., Carlsen, K. H., Chatzi, L., Crameri, R., Eveno, E., Forastiere, F., Garcia-Aymerich, J., Guerra, S., Hammad, H., Heinrich, J., Hirsch, D., Jacquemin, B., Kauffmann, F., Kerkhof, M., Kogevinas, M., Koppelman, G. H., Kowalski, M. L., Lau, S., Lodrup-Carlsen, K. C., Lopez-Botet, M., Lotvall, J., Lupinek, C., Maier, D., Makela, M. J., Martinez, F. D., Mestres, J., Momas, I., Nawijn, M. C., Neubauer, A., Oddie, S., Palkonen, S., Pin, I., Pison, C., Rancé, F., Reitamo, S., Rial-Sebbag, E., Salapatas, M., Siroux, V., Smagghe, D., Torrent, M., Toskala, E., van Cauwenberge, P., van Oosterhout, A. J. M., Varraso, R., von Hertzen, L., Wickman, M., Wijmenga, C., Worm, M., Wright, J., and Zuberbier, T.

Published
2011
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22. Healthy diet as primary and secondary prevention for asthma

Author

Andrianasolo, Roland, Kesse-Guyot, Emmanuelle, ADJIBADE, Moufidath, Hercberg, Serge, Galan, Pilar, Varraso, R., Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA), Recherche en épidémiologie et biostatistique, and Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

23. Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015

Author

Bousquet, J., Anto, J. M., Akdis, M., Auffray, C., Keil, T., Momas, I., Postma, D. S., Valenta, R., Wickman, M., Cambon-Thomsen, A., Haahtela, T., Lambrecht, B. N., Carlsen, K. C. Lodrup, Koppelman, G. H., Sunyer, J., Zuberbier, T., Annesi-Maesano, I., Arno, A., Bindslev-Jensen, C., De Carlo, G., Forastiere, F., Heinrich, J., Kowalski, M. L., Maier, D., Melen, E., Palkonen, S., Smit, H. A., Standl, M., Wright, J., Asarnoj, A., Benet, M., Ballardini, N., Garcia-Aymerich, J., Gehring, U., Guerra, S., Hohman, C., Kull, I., Lupinek, C., Pinart, M., Skrindo, I., Westman, M., Smagghe, D., Akdis, C., Albang, R., Anastasova, V., Anderson, N., Bachert, C., Ballereau, S., Ballester, F., Basagana, X., Bedbrook, A., Bergstrom, A., von Berg, A., Brunekreef, B., Burte, E., Carlsen, K. H., Chatzi, L., Coquet, J. M., Curin, M., Demoly, P., Eller, E., Fantini, M. P., Gerhard, B., Hammad, H., von Hertzen, L., Hovland, V., Jacquemin, B., Just, J., Keller, T., Kerkhof, M., Kiss, R., Kogevinas, M., Koletzko, S., Lau, S., Lehmann, I., Lemonnier, N., McEachan, R., Makela, M., Mestres, J., Minina, E., Mowinckel, P., Nadif, R., Nawijn, M., Oddie, S., Pellet, J., Pin, I., Porta, D., Ranciere, F., Rial-Sebbag, A., Saeys, Y., Schuijs, M. J., Siroux, V., Tischer, C. G., Torrent, M., Varraso, R., De Vocht, J., Wenger, K., Wieser, S., Xu, C., dIRAS RA-2, Risk Assessment, Clinicum, Department of Dermatology, Allergology and Venereology, Bousquet, J., Anto, J.M., Akdis, M., Auffray, C., Keil, T., Momas, I., Postma, D.S., Valenta, R., Wickman, M., Cambon-Thomsen, A., Haahtela, T., Lambrecht, B.N., Lodrup Carlsen, K.C., Koppelman, G.H., Sunyer, J., Zuberbier, T., Annesi-Maesano, I., Arno, A., Bindslev-Jensen, C., De Carlo, G., Forastiere, F., Heinrich, J., Kowalski, M.L., Maier, D., Melén, E., Palkonen, S., Smit, H.A., Standl, M., Wright, J., Asarnoj, A., Benet, M., Ballardini, N., Garcia-Aymerich, J., Gehring, U., Guerra, S., Hohman, C., Kull, I., Lupinek, C., Pinart, M., Skrindo, I., Westman, M., Smagghe, D., Akdis, C., Albang, R., Anastasova, V., Anderson, N., Bachert, C., Ballereau, S., Ballester, F., Basagana, X., Bedbrook, A., Bergstrom, A., von Berg, A., Brunekreef, B., Burte, E., Carlsen, K.H., Chatzi, L., Coquet, J.M., Curin, M., Demoly, P., Eller, E., Fantini, M.P., Gerhard, B., Hammad, H., von Hertzen, L., Hovland, V., Jacquemin, B., Just, J., Keller, T., Kerkhof, M., Kiss, R., Kogevinas, M., Koletzko, S., Lau, S., Lehmann, I., Lemonnier, N., Mceachan, R., Mäkelä, M., Mestres, J., Minina, E., Mowinckel, P., Nadif, R., Nawijn, M., Oddie, S., Pellet, J., Pin, I., Porta, D., Rancière, F., Rial-Sebbag, A., Saeys, Y., Schuijs, M.J., Siroux, V., Tischer, C.G., Torrent, M., Varraso, R., De Vocht, J., Wenger, K., Wieser, S., and Xu, C.

Subjects
multimorbidity, EUROPEAN INNOVATION PARTNERSHIP, humanos, Immunology, IGE SENSITIZATION, política de salud, Review, rhinitis, Inventions, Unión Europea, Hypersensitivity, Medicine and Health Sciences, Journal Article, Humans, Immunology and Allergy, ATOPIC-DERMATITIS, European Union, biología de sistemas, hipersensibilidad, inmunización, inmunoglobulina E, Asthma, Ige, Multimorbidity, Polysensitization, Rhinitis, BIRTH COHORT, IMMUNE-RESPONSES, Health Policy, Systems Biology, asthma, IgE, polysensitization, CHILDHOOD ASTHMA, invenciones, Immunoglobulin E, Prognosis, INTEGRATED CARE, pronóstico, rhiniti, CHRONIC RESPIRATORY-DISEASES, 3121 General medicine, internal medicine and other clinical medicine, Immunization, IMMUNOLOGICAL REACTIVITY, IMMUNOGLOBULIN-E
Abstract

MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.

Published
2016
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24. Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes

Author

Anto, J.M., Bousquet, J., Akdis, M., Auffray, C., Keil, T., Momas, I., Postma, D.S., Valenta, R., Wickman, M., Cambon-Thomsen, A., Haahtela, T., Lambrecht, B.N., Lodrup Carlsen, K.C., Koppelman, G.H., Sunyer, J., Zuberbier, T., Annesi-Maesano, I., Arno, A., Bindslev-Jensen, C., De Carlo, G., Forastiere, F., Heinrich, J., Kowalski, M.L., Maier, D., Melén, E., Smit, H.A., Standl, M., Wright, J., Asarnoj, A., Benet, M., Ballardini, N., Garcia-Aymerich, J., Gehring, U., Guerra, S., Hohmann, C., Kull, I., Lupinek, C., Pinart, M., Skrindo, I., Westman, M., Smagghe, D., Akdis, C., Andersson, N., Bachert, C., Ballereau, S., Ballester, F., Basagana, X., Bedbrook, A., Bergstrom, A., von Berg, A., Brunekreef, B., Burte, E., Carlsen, K.-H., Chatzi, L., Coquet, J.M., Curin, M., Demoly, P., Eller, E., Fantini, M.P., von Hertzen, L., Hovland, V., Jacquemin, B., Just, J., Keller, T., Kiss, R., Kogevinas, M., Koletzko, S., Lau, S., Lehmann, Irina, Lemonnier, N., Mäkelä, M., Mestres, J., Mowinckel, P., Nadif, R., Nawijn, M.C., Pellet, J., Pin, I., Porta, D., Rancière, F., Rial-Sebbag, E., Saeys, Y., Schuijs, M.J., Siroux, V., Tischer, C.G., Torrent, M., Varraso, R., Wenzel, K., Xu, C.-J., Anto, J.M., Bousquet, J., Akdis, M., Auffray, C., Keil, T., Momas, I., Postma, D.S., Valenta, R., Wickman, M., Cambon-Thomsen, A., Haahtela, T., Lambrecht, B.N., Lodrup Carlsen, K.C., Koppelman, G.H., Sunyer, J., Zuberbier, T., Annesi-Maesano, I., Arno, A., Bindslev-Jensen, C., De Carlo, G., Forastiere, F., Heinrich, J., Kowalski, M.L., Maier, D., Melén, E., Smit, H.A., Standl, M., Wright, J., Asarnoj, A., Benet, M., Ballardini, N., Garcia-Aymerich, J., Gehring, U., Guerra, S., Hohmann, C., Kull, I., Lupinek, C., Pinart, M., Skrindo, I., Westman, M., Smagghe, D., Akdis, C., Andersson, N., Bachert, C., Ballereau, S., Ballester, F., Basagana, X., Bedbrook, A., Bergstrom, A., von Berg, A., Brunekreef, B., Burte, E., Carlsen, K.-H., Chatzi, L., Coquet, J.M., Curin, M., Demoly, P., Eller, E., Fantini, M.P., von Hertzen, L., Hovland, V., Jacquemin, B., Just, J., Keller, T., Kiss, R., Kogevinas, M., Koletzko, S., Lau, S., Lehmann, Irina, Lemonnier, N., Mäkelä, M., Mestres, J., Mowinckel, P., Nadif, R., Nawijn, M.C., Pellet, J., Pin, I., Porta, D., Rancière, F., Rial-Sebbag, E., Saeys, Y., Schuijs, M.J., Siroux, V., Tischer, C.G., Torrent, M., Varraso, R., Wenzel, K., and Xu, C.-J.

Abstract

Asthma, rhinitis, and eczema are complex diseases with multiple genetic and environmental factors interlinked through IgE-associated and non–IgE-associated mechanisms. Mechanisms of the Development of ALLergy (MeDALL; EU FP7-CP-IP; project no: 261357; 2010-2015) studied the complex links of allergic diseases at the clinical and mechanistic levels by linking epidemiologic, clinical, and mechanistic research, including in vivo and in vitro models. MeDALL integrated 14 European birth cohorts, including 44,010 participants and 160 cohort follow-ups between pregnancy and age 20 years. Thirteen thousand children were prospectively followed after puberty by using a newly standardized MeDALL Core Questionnaire. A microarray developed for allergen molecules with increased IgE sensitivity was obtained for 3,292 children. Estimates of air pollution exposure from previous studies were available for 10,000 children. Omics data included those from historical genome-wide association studies (23,000 children) and DNA methylation (2,173), targeted multiplex biomarker (1,427), and transcriptomic (723) studies. Using classical epidemiology and machine-learning methods in 16,147 children aged 4 years and 11,080 children aged 8 years, MeDALL showed the multimorbidity of eczema, rhinitis, and asthma and estimated that only 38% of multimorbidity was attributable to IgE sensitization. MeDALL has proposed a new vision of multimorbidity independent of IgE sensitization, and has shown that monosensitization and polysensitization represent 2 distinct phenotypes. The translational component of MeDALL is shown by the identification of a novel allergic phenotype characterized by polysensitization and multimorbidity, which is associated with the frequency, persistence, and severity of allergic symptoms. The results of MeDALL will help integrate personalized, predictive, preventative, and participatory approaches in allergic diseases.

Published
2017

25. Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story Mechanisms of the Development of ALLergy; EUFP7-CP-IP; Project No: 261357; 2010-2015

Author

Bousquet, J., Anto, J. M., Akdis, M., Auffray, C., Keil, T., Momas, I., Postma, D. S., Valenta, R., Wickman, M., Cambon-Thomsen, A., Haahtela, T., Lambrecht, B. N., Lodrup Carlsen, K. C., Koppelman, G. H., Sunyer, J., Zuberbier, T., Annesi-Maesano, I., Arno, A., Bindslev-Jensen, C., De Carlo, G., Forastiere, F., Heinrich, J., Kowalski, M. L., Maier, D., Melen, E., Palkonen, S., Smit, H. A., Standl, M., Wright, J., Asarnoj, A., Benet, M., Ballardini, N., Garcia-Aymerich, J., Gehring, U., Guerra, S., Hohman, C., Kull, I., Lupinek, C., Pinart, M., Skrindo, I., Westman, M., Smagghe, D., Akdis, C., Albang, R., Anastasova, V., Anderson, N., Bachert, C., Ballereau, S., Ballester, F., Basagana, X., Bedbrook, A., Bergstrom, A., von Berg, A., Brunekreef, B., Burte, E., Carlsen, K.H., Chatzi, L., Coquet, J.M., Curin, M., Demoly, P., Eller, E., Fantini, M.P., Gerhard, B., Hammad, H., von Hertzen, L., Hovland, V., Jacquemin, B., Just, J., Keller, T., Kerkhof, M., Kiss, R., Kogevinas, M., Koletzko, S., Lau, S., Lehmann, I., Lemonnier, N., McEachan, R., Makela, M., Mestres, J., Minina, E., Mowinckel, P., Nadif, R., Nawijn, M., Oddie, S., Pellet, J., Pin, I., Porta, D., Rancière, F., Rial-Sebbag, A., Schuijs, M.J., Siroux, V., Tischer, C.G., Torrent, M., Varraso, R., De Vocht, J., Wenger, K., Wieser, S., and Xu, C.

Subjects
ddc:610
Abstract

MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.

Published
2016

26. Systematic Review on the Definition of Allergic Diseases in Children: The MeDALL Study

Author

Pinart, M, Albang, R, Maier, D, Duran-Tauleria, E, Mena, G, Gimeno-Santos, E, Sola, I, Garcia-Aymerich, J, Guerra, S, Stein, RT, Benet, M, Carlsen, KH, Herr, M, Jacquemin, B, Momas, I, Pin, I, Ranciere, F, Smit, HA, Varraso, R, Bonfill, X, Keil, T, Bousquet, J, and Anto, JM

Subjects
Phenotype, Urticaria, Allergy, Eczema, Disease definition, Anaphylaxis, Asthma, Rhinitis
Abstract

Background: During the last decades, a large number of phenotypes and disease classifications of allergic diseases have been proposed. Despite the heterogeneity across studies, no systematic review has been conducted on phenotype classification and the criteria that define allergic diseases. We aimed to identify clinically expressed, population-based phenotypes of allergic diseases and their interrelationships, to explore disease heterogeneity and to evaluate the measurements employed in disease diagnosis. Methods: We conducted a search of MEDLINE up to December 2012, to identify relevant original studies published in the English language that examine at least one objective of this systematic review in subjects aged 0-18 years. The screening of titles and abstracts and the extraction of data were conducted independently by two reviewers. Results: From a total of 13,767 citations, 197 studies met the criteria for inclusion, with 54% being cohort studies. Allergic diseases were studied as a single entity in 55% (109/197) of the studies or in the context of multimorbidity in 45%. Asthma accounted for 81.7% of the studies examining single diseases. Overall, up to 33 different phenotypes of allergic disease were reported. Transient early, late-onset and persistent wheeze were the most frequently reported phenotypes. Most studies (78%) used questionnaires. The skin-prick test was the preferred measurement of sensitization (64%). Spirometry and bronchial hyperresponsiveness were assessed in one third of the studies, peak flow rate in 8.6% and disease severity in 35%. Conclusions: Studies reporting phenotypes of allergic diseases in children are highly heterogeneous and often lack objective phenotypical measures. A concerted effort to standardize methods and terminology is necessary. (C) 2015 S. Karger AG, Basel

Published
2015

27. Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015

Author

Bousquet, J, Anto, J M, Akdis, M, Auffray, C, Keil, T, Momas, I, Postma, D S, Valenta, R, Wickman, M, Cambon-Thomsen, A, Haahtela, T, Lambrecht, B N, Lodrup Carlsen, K C, Koppelman, G H, Sunyer, J, Zuberbier, T, Annesi-Maesano, I, Arno, A, Bindslev-Jensen, C, De Carlo, G, Forastiere, F, Heinrich, J, Kowalski, M L, Maier, D, Melén, E, Palkonen, S, Smit, H A, Standl, M, Wright, J, Asarnoj, A, Benet, M, Ballardini, N, Garcia-Aymerich, J, Gehring, U, Guerra, S, Hohman, C, Kull, I, Lupinek, C, Pinart, M, Skrindo, I, Westman, M, Smagghe, D, Akdis, C, Albang, R, Anastasova, V, Anderson, N, Bachert, C, Ballereau, S, Ballester, F, Basagana, X, Bedbrook, A, Bergstrom, A, von Berg, A, Brunekreef, B, Burte, E, Carlsen, K H, Chatzi, L, Coquet, J M, Curin, M, Demoly, P, Eller, E, Fantini, M P, Gerhard, B, Hammad, H, von Hertzen, L, Hovland, V, Jacquemin, B, Just, J, Keller, T, Kerkhof, M, Kiss, R, Kogevinas, M, Koletzko, S, Lau, S, Lehmann, I, Lemonnier, N, McEachan, R, Mäkelä, M, Mestres, J, Minina, E, Mowinckel, P, Nadif, R, Nawijn, M, Oddie, S, Pellet, J, Pin, I, Porta, D, Rancière, F, Rial-Sebbag, A, Saeys, Y, Schuijs, M J, Siroux, V, Tischer, C G, Torrent, M, Varraso, R, De Vocht, J, Wenger, K, Wieser, S, Xu, C, Bousquet, J, Anto, J M, Akdis, M, Auffray, C, Keil, T, Momas, I, Postma, D S, Valenta, R, Wickman, M, Cambon-Thomsen, A, Haahtela, T, Lambrecht, B N, Lodrup Carlsen, K C, Koppelman, G H, Sunyer, J, Zuberbier, T, Annesi-Maesano, I, Arno, A, Bindslev-Jensen, C, De Carlo, G, Forastiere, F, Heinrich, J, Kowalski, M L, Maier, D, Melén, E, Palkonen, S, Smit, H A, Standl, M, Wright, J, Asarnoj, A, Benet, M, Ballardini, N, Garcia-Aymerich, J, Gehring, U, Guerra, S, Hohman, C, Kull, I, Lupinek, C, Pinart, M, Skrindo, I, Westman, M, Smagghe, D, Akdis, C, Albang, R, Anastasova, V, Anderson, N, Bachert, C, Ballereau, S, Ballester, F, Basagana, X, Bedbrook, A, Bergstrom, A, von Berg, A, Brunekreef, B, Burte, E, Carlsen, K H, Chatzi, L, Coquet, J M, Curin, M, Demoly, P, Eller, E, Fantini, M P, Gerhard, B, Hammad, H, von Hertzen, L, Hovland, V, Jacquemin, B, Just, J, Keller, T, Kerkhof, M, Kiss, R, Kogevinas, M, Koletzko, S, Lau, S, Lehmann, I, Lemonnier, N, McEachan, R, Mäkelä, M, Mestres, J, Minina, E, Mowinckel, P, Nadif, R, Nawijn, M, Oddie, S, Pellet, J, Pin, I, Porta, D, Rancière, F, Rial-Sebbag, A, Saeys, Y, Schuijs, M J, Siroux, V, Tischer, C G, Torrent, M, Varraso, R, De Vocht, J, Wenger, K, Wieser, S, and Xu, C

Abstract

MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.

Published
2016

28. Paving the way of systems biology and precision medicine in allergic diseases

Author

University of Helsinki, Clinicum, University of Helsinki, Departments of Dermatology, Allergology and Venereology, Bousquet, J., Anto, J. M., Akdis, M., Auffray, C., Keil, T., Momas, I., Postma, D. S., Valenta, R., Wickman, M., Cambon-Thomsen, A., Haahtela, T., Lambrecht, B. N., Carlsen, K. C. Lodrup, Koppelman, G. H., Sunyer, J., Zuberbier, T., Annesi-Maesano, I., Arno, A., Bindslev-Jensen, C., De Carlo, G., Forastiere, F., Heinrich, J., Kowalski, M. L., Maier, D., Melen, E., Palkonen, S., Smit, H. A., Standl, M., Wright, J., Asarnoj, A., Benet, M., Ballardini, N., Garcia-Aymerich, J., Gehring, U., Guerra, S., Hohman, C., Kull, I., Lupinek, C., Pinart, M., Skrindo, I., Westman, M., Smagghe, D., Akdis, C., Albang, R., Anastasova, V., Anderson, N., Bachert, C., Ballereau, S., Ballester, F., Basagana, X., Bedbrook, A., Bergstrom, A., von Berg, A., Brunekreef, B., Burte, E., Carlsen, K. H., Chatzi, L., Coquet, J. M., Curin, M., Demoly, P., Eller, E., Fantini, M. P., Gerhard, B., Hammad, H., von Hertzen, L., Hovland, V., Jacquemin, B., Just, J., Keller, T., Kerkhof, M., Kiss, R., Kogevinas, M., Koletzko, S., Lau, S., Lehmann, I., Lemonnier, N., McEachan, R., Mäkelä, M., Mestres, J., Minina, E., Mowinckel, P., Nadif, R., Nawijn, M., Oddie, S., Pellet, J., Pin, I., Porta, D., Ranciere, F., Rial-Sebbag, A., Saeys, Y., Schuijs, M. J., Siroux, V., Tischer, C. G., Torrent, M., Varraso, R., De Vocht, J., Wenger, K., Wieser, S., Xu, C., University of Helsinki, Clinicum, University of Helsinki, Departments of Dermatology, Allergology and Venereology, Bousquet, J., Anto, J. M., Akdis, M., Auffray, C., Keil, T., Momas, I., Postma, D. S., Valenta, R., Wickman, M., Cambon-Thomsen, A., Haahtela, T., Lambrecht, B. N., Carlsen, K. C. Lodrup, Koppelman, G. H., Sunyer, J., Zuberbier, T., Annesi-Maesano, I., Arno, A., Bindslev-Jensen, C., De Carlo, G., Forastiere, F., Heinrich, J., Kowalski, M. L., Maier, D., Melen, E., Palkonen, S., Smit, H. A., Standl, M., Wright, J., Asarnoj, A., Benet, M., Ballardini, N., Garcia-Aymerich, J., Gehring, U., Guerra, S., Hohman, C., Kull, I., Lupinek, C., Pinart, M., Skrindo, I., Westman, M., Smagghe, D., Akdis, C., Albang, R., Anastasova, V., Anderson, N., Bachert, C., Ballereau, S., Ballester, F., Basagana, X., Bedbrook, A., Bergstrom, A., von Berg, A., Brunekreef, B., Burte, E., Carlsen, K. H., Chatzi, L., Coquet, J. M., Curin, M., Demoly, P., Eller, E., Fantini, M. P., Gerhard, B., Hammad, H., von Hertzen, L., Hovland, V., Jacquemin, B., Just, J., Keller, T., Kerkhof, M., Kiss, R., Kogevinas, M., Koletzko, S., Lau, S., Lehmann, I., Lemonnier, N., McEachan, R., Mäkelä, M., Mestres, J., Minina, E., Mowinckel, P., Nadif, R., Nawijn, M., Oddie, S., Pellet, J., Pin, I., Porta, D., Ranciere, F., Rial-Sebbag, A., Saeys, Y., Schuijs, M. J., Siroux, V., Tischer, C. G., Torrent, M., Varraso, R., De Vocht, J., Wenger, K., Wieser, S., and Xu, C.

Abstract

MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.

Published
2016

29. Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015

Author

dIRAS RA-2, Risk Assessment, Bousquet, J, Anto, J M, Akdis, M, Auffray, C, Keil, T, Momas, I, Postma, D S, Valenta, R, Wickman, M, Cambon-Thomsen, A, Haahtela, T, Lambrecht, B N, Lodrup Carlsen, K C, Koppelman, G H, Sunyer, J, Zuberbier, T, Annesi-Maesano, I, Arno, A, Bindslev-Jensen, C, De Carlo, G, Forastiere, F, Heinrich, J, Kowalski, M L, Maier, D, Melén, E, Palkonen, S, Smit, H A, Standl, M, Wright, J, Asarnoj, A, Benet, M, Ballardini, N, Garcia-Aymerich, J, Gehring, U, Guerra, S, Hohman, C, Kull, I, Lupinek, C, Pinart, M, Skrindo, I, Westman, M, Smagghe, D, Akdis, C, Albang, R, Anastasova, V, Anderson, N, Bachert, C, Ballereau, S, Ballester, F, Basagana, X, Bedbrook, A, Bergstrom, A, von Berg, A, Brunekreef, B, Burte, E, Carlsen, K H, Chatzi, L, Coquet, J M, Curin, M, Demoly, P, Eller, E, Fantini, M P, Gerhard, B, Hammad, H, von Hertzen, L, Hovland, V, Jacquemin, B, Just, J, Keller, T, Kerkhof, M, Kiss, R, Kogevinas, M, Koletzko, S, Lau, S, Lehmann, I, Lemonnier, N, McEachan, R, Mäkelä, M, Mestres, J, Minina, E, Mowinckel, P, Nadif, R, Nawijn, M, Oddie, S, Pellet, J, Pin, I, Porta, D, Rancière, F, Rial-Sebbag, A, Saeys, Y, Schuijs, M J, Siroux, V, Tischer, C G, Torrent, M, Varraso, R, De Vocht, J, Wenger, K, Wieser, S, Xu, C, dIRAS RA-2, Risk Assessment, Bousquet, J, Anto, J M, Akdis, M, Auffray, C, Keil, T, Momas, I, Postma, D S, Valenta, R, Wickman, M, Cambon-Thomsen, A, Haahtela, T, Lambrecht, B N, Lodrup Carlsen, K C, Koppelman, G H, Sunyer, J, Zuberbier, T, Annesi-Maesano, I, Arno, A, Bindslev-Jensen, C, De Carlo, G, Forastiere, F, Heinrich, J, Kowalski, M L, Maier, D, Melén, E, Palkonen, S, Smit, H A, Standl, M, Wright, J, Asarnoj, A, Benet, M, Ballardini, N, Garcia-Aymerich, J, Gehring, U, Guerra, S, Hohman, C, Kull, I, Lupinek, C, Pinart, M, Skrindo, I, Westman, M, Smagghe, D, Akdis, C, Albang, R, Anastasova, V, Anderson, N, Bachert, C, Ballereau, S, Ballester, F, Basagana, X, Bedbrook, A, Bergstrom, A, von Berg, A, Brunekreef, B, Burte, E, Carlsen, K H, Chatzi, L, Coquet, J M, Curin, M, Demoly, P, Eller, E, Fantini, M P, Gerhard, B, Hammad, H, von Hertzen, L, Hovland, V, Jacquemin, B, Just, J, Keller, T, Kerkhof, M, Kiss, R, Kogevinas, M, Koletzko, S, Lau, S, Lehmann, I, Lemonnier, N, McEachan, R, Mäkelä, M, Mestres, J, Minina, E, Mowinckel, P, Nadif, R, Nawijn, M, Oddie, S, Pellet, J, Pin, I, Porta, D, Rancière, F, Rial-Sebbag, A, Saeys, Y, Schuijs, M J, Siroux, V, Tischer, C G, Torrent, M, Varraso, R, De Vocht, J, Wenger, K, Wieser, S, and Xu, C

Published
2016

30. Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015

Author

Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Public Health Epidemiologie, Epi Infectieziekten Team 3, Infection & Immunity, Bousquet, J, Anto, J M, Akdis, M, Auffray, C, Keil, T, Momas, I, Postma, D S, Valenta, R, Wickman, M, Cambon-Thomsen, A, Haahtela, T, Lambrecht, B N, Lodrup Carlsen, K C, Koppelman, G H, Sunyer, J, Zuberbier, T, Annesi-Maesano, I, Arno, A, Bindslev-Jensen, C, De Carlo, G, Forastiere, F, Heinrich, J, Kowalski, M L, Maier, D, Melén, E, Palkonen, S, Smit, H A, Standl, M, Wright, J, Asarnoj, A, Benet, M, Ballardini, N, Garcia-Aymerich, J, Gehring, U, Guerra, S, Hohman, C, Kull, I, Lupinek, C, Pinart, M, Skrindo, I, Westman, M, Smagghe, D, Akdis, C, Albang, R, Anastasova, V, Anderson, N, Bachert, C, Ballereau, S, Ballester, F, Basagana, X, Bedbrook, A, Bergstrom, A, von Berg, A, Brunekreef, B, Burte, E, Carlsen, K H, Chatzi, L, Coquet, J M, Curin, M, Demoly, P, Eller, E, Fantini, M P, Gerhard, B, Hammad, H, von Hertzen, L, Hovland, V, Jacquemin, B, Just, J, Keller, T, Kerkhof, M, Kiss, R, Kogevinas, M, Koletzko, S, Lau, S, Lehmann, I, Lemonnier, N, McEachan, R, Mäkelä, M, Mestres, J, Minina, E, Mowinckel, P, Nadif, R, Nawijn, M, Oddie, S, Pellet, J, Pin, I, Porta, D, Rancière, F, Rial-Sebbag, A, Saeys, Y, Schuijs, M J, Siroux, V, Tischer, C G, Torrent, M, Varraso, R, De Vocht, J, Wenger, K, Wieser, S, Xu, C, Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Public Health Epidemiologie, Epi Infectieziekten Team 3, Infection & Immunity, Bousquet, J, Anto, J M, Akdis, M, Auffray, C, Keil, T, Momas, I, Postma, D S, Valenta, R, Wickman, M, Cambon-Thomsen, A, Haahtela, T, Lambrecht, B N, Lodrup Carlsen, K C, Koppelman, G H, Sunyer, J, Zuberbier, T, Annesi-Maesano, I, Arno, A, Bindslev-Jensen, C, De Carlo, G, Forastiere, F, Heinrich, J, Kowalski, M L, Maier, D, Melén, E, Palkonen, S, Smit, H A, Standl, M, Wright, J, Asarnoj, A, Benet, M, Ballardini, N, Garcia-Aymerich, J, Gehring, U, Guerra, S, Hohman, C, Kull, I, Lupinek, C, Pinart, M, Skrindo, I, Westman, M, Smagghe, D, Akdis, C, Albang, R, Anastasova, V, Anderson, N, Bachert, C, Ballereau, S, Ballester, F, Basagana, X, Bedbrook, A, Bergstrom, A, von Berg, A, Brunekreef, B, Burte, E, Carlsen, K H, Chatzi, L, Coquet, J M, Curin, M, Demoly, P, Eller, E, Fantini, M P, Gerhard, B, Hammad, H, von Hertzen, L, Hovland, V, Jacquemin, B, Just, J, Keller, T, Kerkhof, M, Kiss, R, Kogevinas, M, Koletzko, S, Lau, S, Lehmann, I, Lemonnier, N, McEachan, R, Mäkelä, M, Mestres, J, Minina, E, Mowinckel, P, Nadif, R, Nawijn, M, Oddie, S, Pellet, J, Pin, I, Porta, D, Rancière, F, Rial-Sebbag, A, Saeys, Y, Schuijs, M J, Siroux, V, Tischer, C G, Torrent, M, Varraso, R, De Vocht, J, Wenger, K, Wieser, S, and Xu, C

Published
2016

32. Paving the way of systems biology and precision medicine in allergic diseases: the Me DALL success story

Author

Bousquet, J., primary, Anto, J. M., additional, Akdis, M., additional, Auffray, C., additional, Keil, T., additional, Momas, I., additional, Postma, D.S., additional, Valenta, R., additional, Wickman, M., additional, Cambon‐Thomsen, A., additional, Haahtela, T., additional, Lambrecht, B. N., additional, Lodrup Carlsen, K. C., additional, Koppelman, G. H., additional, Sunyer, J., additional, Zuberbier, T., additional, Annesi‐Maesano, I., additional, Arno, A., additional, Bindslev‐Jensen, C., additional, De Carlo, G., additional, Forastiere, F., additional, Heinrich, J., additional, Kowalski, M. L., additional, Maier, D., additional, Melén, E., additional, Palkonen, S., additional, Smit, H. A., additional, Standl, M., additional, Wright, J., additional, Asarnoj, A., additional, Benet, M., additional, Ballardini, N., additional, Garcia‐Aymerich, J., additional, Gehring, U., additional, Guerra, S., additional, Hohman, C., additional, Kull, I., additional, Lupinek, C., additional, Pinart, M., additional, Skrindo, I., additional, Westman, M., additional, Smagghe, D., additional, Akdis, C., additional, Albang, R., additional, Anastasova, V., additional, Anderson, N., additional, Bachert, C., additional, Ballereau, S., additional, Ballester, F., additional, Basagana, X., additional, Bedbrook, A., additional, Bergstrom, A., additional, Berg, A., additional, Brunekreef, B., additional, Burte, E., additional, Carlsen, K. H., additional, Chatzi, L., additional, Coquet, J. M., additional, Curin, M., additional, Demoly, P., additional, Eller, E., additional, Fantini, M. P., additional, Gerhard, B., additional, Hammad, H., additional, Hertzen, L., additional, Hovland, V., additional, Jacquemin, B., additional, Just, J., additional, Keller, T., additional, Kerkhof, M., additional, Kiss, R., additional, Kogevinas, M., additional, Koletzko, S., additional, Lau, S., additional, Lehmann, I., additional, Lemonnier, N., additional, McEachan, R., additional, Mäkelä, M., additional, Mestres, J., additional, Minina, E., additional, Mowinckel, P., additional, Nadif, R., additional, Nawijn, M., additional, Oddie, S., additional, Pellet, J., additional, Pin, I., additional, Porta, D., additional, Rancière, F., additional, Rial‐Sebbag, A., additional, Saeys, Y., additional, Schuijs, M. J., additional, Siroux, V., additional, Tischer, C. G., additional, Torrent, M., additional, Varraso, R., additional, De Vocht, J., additional, Wenger, K., additional, Wieser, S., additional, and Xu, C., additional

Published
2016
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34. Operational definition of Active and Healthy Ageing (AHA) : A conceptual framework

Author

Bousquet, J., Kuh, D., Bewick, M., Standberg, T., Farrell, J., Pengelly, R., Joel, M. E., Rodriguez Manas, L., Mercier, J., Bringer, J., Camuzat, T., Bourret, R., Bedbrook, A., Kowalski, M. L., Samolinski, B., Bonini, S., Brayne, C., Michel, J. P., Venne, J., Viriot-Durandal, P., Alonso, J., Avignon, A., Ben-Shlomo, Y., Bousquet, P. J., Combe, B., Cooper, R., Hardy, R., Iaccarino, G., Keil, T., Kesse-Guyot, E., Momas, I., Ritchie, K., Robine, J. M., Thijs, C., Tischer, C., Vellas, B., Zaidi, A., Alonso, F., Ranberg, K. Andersen, Andreeva, V., Ankri, J., Arnavielhe, S., Arshad, H., Auge, P., Berr, C., Bertone, P., Blain, H., Blasimme, A., Buijs, G. J., Caimmi, D., Carriazo, A., Cesario, A., Coletta, J., Cosco, T., Criton, M., Cuisinier, F., Demoly, P., Fernandez-Nocelo, S., Fougere, B., Garcia-Aymerich, J., Goldberg, M., Guldemond, N., Gutter, Z., Harman, D., Hendry, A., Heve, D., Illario, M., Jeandel, C., Krauss-Etschmann, S., Krys, O., Kula, D., Laune, D., Lehmann, S., Maier, D., Malva, J., Matignon, P., Melen, E., Mercier, G., Moda, G., Nizinkska, A., Nogues, M., O'Neill, M., Pelissier, J. Y., Poethig, D., Porta, D., Postma, D., Puisieux, F., Richards, M., Robalo-Cordeiro, C., Romano, V., Roubille, F., Schulz, H., Scott, A., Senesse, P., Slagter, S., Smit, H. A., Somekh, D., Stafford, M., Suanzes, J., Todo-Bom, A., Touchon, J., Traver-Salcedo, V., Van Beurden, M., Varraso, R., Vergara, I., Villalba-Mora, E., Wilson, N., Wouters, E., Zins, M., Bousquet, J., Kuh, D., Bewick, M., Standberg, T., Farrell, J., Pengelly, R., Joel, M. E., Rodriguez Manas, L., Mercier, J., Bringer, J., Camuzat, T., Bourret, R., Bedbrook, A., Kowalski, M. L., Samolinski, B., Bonini, S., Brayne, C., Michel, J. P., Venne, J., Viriot-Durandal, P., Alonso, J., Avignon, A., Ben-Shlomo, Y., Bousquet, P. J., Combe, B., Cooper, R., Hardy, R., Iaccarino, G., Keil, T., Kesse-Guyot, E., Momas, I., Ritchie, K., Robine, J. M., Thijs, C., Tischer, C., Vellas, B., Zaidi, A., Alonso, F., Ranberg, K. Andersen, Andreeva, V., Ankri, J., Arnavielhe, S., Arshad, H., Auge, P., Berr, C., Bertone, P., Blain, H., Blasimme, A., Buijs, G. J., Caimmi, D., Carriazo, A., Cesario, A., Coletta, J., Cosco, T., Criton, M., Cuisinier, F., Demoly, P., Fernandez-Nocelo, S., Fougere, B., Garcia-Aymerich, J., Goldberg, M., Guldemond, N., Gutter, Z., Harman, D., Hendry, A., Heve, D., Illario, M., Jeandel, C., Krauss-Etschmann, S., Krys, O., Kula, D., Laune, D., Lehmann, S., Maier, D., Malva, J., Matignon, P., Melen, E., Mercier, G., Moda, G., Nizinkska, A., Nogues, M., O'Neill, M., Pelissier, J. Y., Poethig, D., Porta, D., Postma, D., Puisieux, F., Richards, M., Robalo-Cordeiro, C., Romano, V., Roubille, F., Schulz, H., Scott, A., Senesse, P., Slagter, S., Smit, H. A., Somekh, D., Stafford, M., Suanzes, J., Todo-Bom, A., Touchon, J., Traver-Salcedo, V., Van Beurden, M., Varraso, R., Vergara, I., Villalba-Mora, E., Wilson, N., Wouters, E., and Zins, M.

Published
2015

35. Operational definition of Active and Healthy Ageing (AHA): A conceptual framework

Author

Cardiometabolic Health, Epi Infectieziekten Team 1, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Bousquet, J., Kuh, D., Bewick, M., Standberg, T., Farrell, J., Pengelly, R., Joel, M. E., Rodriguez Manas, L., Mercier, J., Bringer, J., Camuzat, T., Bourret, R., Bedbrook, A., Kowalski, M. L., Samolinski, B., Bonini, S., Brayne, C., Michel, J. P., Venne, J., Viriot-Durandal, P., Alonso, J., Avignon, A., Ben-Shlomo, Y., Bousquet, P. J., Combe, B., Cooper, R., Hardy, R., Iaccarino, G., Keil, T., Kesse-Guyot, E., Momas, I., Ritchie, K., Robine, J. M., Thijs, C., Tischer, C., Vellas, B., Zaidi, A., Alonso, F., Ranberg, K. Andersen, Andreeva, V., Ankri, J., Arnavielhe, S., Arshad, H., Auge, P., Berr, C., Bertone, P., Blain, H., Blasimme, A., Buijs, G. J., Caimmi, D., Carriazo, A., Cesario, A., Coletta, J., Cosco, T., Criton, M., Cuisinier, F., Demoly, P., Fernandez-Nocelo, S., Fougere, B., Garcia-Aymerich, J., Goldberg, M., Guldemond, N., Gutter, Z., Harman, D., Hendry, A., Heve, D., Illario, M., Jeandel, C., Krauss-Etschmann, S., Krys, O., Kula, D., Laune, D., Lehmann, S., Maier, D., Malva, J., Matignon, P., Melen, E., Mercier, G., Moda, G., Nizinkska, A., Nogues, M., O'Neill, M., Pelissier, J. Y., Poethig, D., Porta, D., Postma, D., Puisieux, F., Richards, M., Robalo-Cordeiro, C., Romano, V., Roubille, F., Schulz, H., Scott, A., Senesse, P., Slagter, S., Smit, H. A., Somekh, D., Stafford, M., Suanzes, J., Todo-Bom, A., Touchon, J., Traver-Salcedo, V., Van Beurden, M., Varraso, R., Vergara, I., Villalba-Mora, E., Wilson, N., Wouters, E., Zins, M., Cardiometabolic Health, Epi Infectieziekten Team 1, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Bousquet, J., Kuh, D., Bewick, M., Standberg, T., Farrell, J., Pengelly, R., Joel, M. E., Rodriguez Manas, L., Mercier, J., Bringer, J., Camuzat, T., Bourret, R., Bedbrook, A., Kowalski, M. L., Samolinski, B., Bonini, S., Brayne, C., Michel, J. P., Venne, J., Viriot-Durandal, P., Alonso, J., Avignon, A., Ben-Shlomo, Y., Bousquet, P. J., Combe, B., Cooper, R., Hardy, R., Iaccarino, G., Keil, T., Kesse-Guyot, E., Momas, I., Ritchie, K., Robine, J. M., Thijs, C., Tischer, C., Vellas, B., Zaidi, A., Alonso, F., Ranberg, K. Andersen, Andreeva, V., Ankri, J., Arnavielhe, S., Arshad, H., Auge, P., Berr, C., Bertone, P., Blain, H., Blasimme, A., Buijs, G. J., Caimmi, D., Carriazo, A., Cesario, A., Coletta, J., Cosco, T., Criton, M., Cuisinier, F., Demoly, P., Fernandez-Nocelo, S., Fougere, B., Garcia-Aymerich, J., Goldberg, M., Guldemond, N., Gutter, Z., Harman, D., Hendry, A., Heve, D., Illario, M., Jeandel, C., Krauss-Etschmann, S., Krys, O., Kula, D., Laune, D., Lehmann, S., Maier, D., Malva, J., Matignon, P., Melen, E., Mercier, G., Moda, G., Nizinkska, A., Nogues, M., O'Neill, M., Pelissier, J. Y., Poethig, D., Porta, D., Postma, D., Puisieux, F., Richards, M., Robalo-Cordeiro, C., Romano, V., Roubille, F., Schulz, H., Scott, A., Senesse, P., Slagter, S., Smit, H. A., Somekh, D., Stafford, M., Suanzes, J., Todo-Bom, A., Touchon, J., Traver-Salcedo, V., Van Beurden, M., Varraso, R., Vergara, I., Villalba-Mora, E., Wilson, N., Wouters, E., and Zins, M.

Published
2015

36. Work related asthma. A causal analysis controlling the healthy worker effect

Author

Dumas, O., Le Moual, N., Siroux, V., Heederik, D., Garcia-Aymerich, J., Varraso, R., Kauffmann, F., Basagaña, X., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Faraldo, Beatrice, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Division of Occupational and Environmental Health, Institute for Risk Assessment (IRAS), Utrecht University [Utrecht], CIBER de Epidemiología y Salud Pública (CIBERESP), IMIM-Hospital del Mar, Generalitat de Catalunya, Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, Universitat Pompeu Fabra [Barcelona] (UPF), French Agency of health safety, environment and work (AFSSET-EST-09-15), Hospitalprogram of clinical research (PHRC)-Paris, National Research Agency - Health environment,health-work program (ANR-SEST 2005), National Research Agency (ANR- 2010-PRSP-003), Merck Sharp & Dohme (MSD), Isere committee against respiratory diseases(COMARES), French Ministry of foreign and European affairs / Netherland organization forscientific research (NWO) Van Gogh program for French Dutch cooperation, and theUniversity Paris Sud 11 - ED420 doctoral grant., Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut National de la Santé et de la Recherche Médicale (INSERM)-EFS-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF), Risk Assessment of Toxic and Immunomodulatory Agents, and Dep IRAS

Subjects
Male, Pediatrics, Longitudinal study, Marginal structural model, Severity of Illness Index, MESH: Occupational Exposure, 0302 clinical medicine, Healthy worker effect, Reference Values, Epidemiology, Odds Ratio, Medicine, Longitudinal Studies, MESH: Incidence, 030212 general & internal medicine, Asthma, Occupational, MESH: Longitudinal Studies, MESH: Aged, MESH: Middle Aged, Incidence, Incidence (epidemiology), MESH: Sex Distribution, MESH: Reference Values, Middle Aged, MESH: Confidence Intervals, MESH: Case-Control Studies, 3. Good health, MESH: Young Adult, Female, France, Adult, MESH: Healthy Worker Effect, medicine.medical_specialty, Adolescent, Coronacrisis-Taverne, Young Adult, 03 medical and health sciences, Age Distribution, Occupational Exposure, MESH: Severity of Illness Index, Environmental health, Confidence Intervals, Humans, Marginal structural models, Occupations, Sex Distribution, MESH: Age Distribution, Aged, Asthma, MESH: Adolescent, MESH: Asthma, Occupational, MESH: Humans, MESH: Occupations, business.industry, Public Health, Environmental and Occupational Health, Case-control study, MESH: Adult, Odds ratio, medicine.disease, MESH: Male, MESH: Odds Ratio, Confidence interval, MESH: France, 030228 respiratory system, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Case-Control Studies, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female
Abstract

Objectives The healthy worker effect usually leads to underestimation of the association between occupational exposure and asthma. The role of irritants in work-related asthma is disputed. We estimated the effect of occupational exposure on asthma expression in a longitudinal study, using marginal structural modelling to control for the healthy worker effect. Methods Analyses included 1284 participants (17–79 years, 48% men) from the follow-up (2003–2007) of the French Epidemiological study on the Genetics and Environment of Asthma (case-control study). Age at asthma onset, periods with/without attacks over lifetime and occupational history were recorded retrospectively. Exposures to known asthmagens, irritants or low level of chemicals/allergens were evaluated through a job-exposure matrix. The job history was reconstructed into 5-year intervals. Results Thirty-one per cent of subjects had ever been exposed to occupational asthmagens. Among the 38% of subjects who had asthma (ever), presence of attacks was reported in 52% of all time periods. Using standard analyses, no association was observed between exposure to known asthmagens (OR (95% CI): 0.99 (0.72 to 1.36)) or to irritants/low level of chemicals/allergens (0.82 (0.56 to 1.20)) and asthma attacks. Using a marginal structural model, all associations increased with suggestive evidence for known asthmagens (1.26 (0.90 to 1.76)), and reaching statistical significance for irritants/low level of chemicals/allergens (1.56 (1.02 to 2.40)). Conclusions The healthy worker effect has an important impact in risk assessment in work-related asthma studies. Marginal structural models are useful to eliminate imbalances in exposure due to disease-driven selection. Results support the role of irritants in work-related asthma.

Published
2013
Full Text
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37. Severe Chronic Allergic (and related) Diseases: a uniform approach- a MeDALL- GA(2)LEN-ARIA Position Paper

Author

WHO Collaborating Center for Asthma, Rhinitis, Bousquet, J, Anto, Jm, Demoly, P, Schünemann, Hj, Togias, A, Akdis, M, Auffray, C, Bachert, C, Bieber, T, Bousquet, Pj, Carlsen, Kh, Casale, Tb, Cruz, Aa, Keil, T, Lodrup Carlsen KC, Maurer, M, Ohta, K, Papadopoulos, Ng, Roman Rodriguez, M, Samolinski, B, Agache, I, Andrianarisoa, A, Ang, Cs, Annesi Maesano, I, Ballester, F, Baena Cagnani CE, Basagaña, X, Bateman, Ed, Bel, Eh, Bedbrook, A, Beghe', Bianca, Beji, M, Ben Kheder, A, Benet, M, Bennoor, Ks, Bergmann, Kc, Berrissoul, F, Bindslev Jensen, C, Bleecker, Er, Bonini, S, Boner, Al, Boulet, Lp, Brightling, Ce, Brozek, Jl, Bush, A, Busse, Ww, Camargos, Pa, Canonica, Gw, Carr, W, Cesario, A, Chen, Yz, Chiriac, Am, Costa, Dj, Cox, L, Custovic, A, Dahl, R, Darsow, U, Didi, T, Dolen, Wk, Douagui, H, Dubakiene, R, El Meziane, A, Fonseca, Ja, Fokkens, Wj, Fthenou, E, Gamkrelidze, A, Garcia Aymerich, J, Gerth van Wijk, R, Gimeno Santos, E, Guerra, S, Haahtela, T, Haddad, H, Hellings, Pw, Hellquist Dahl, B, Hohmann, C, Howarth, P, Hourihane, Jo, Humbert, M, Jacquemin, B, Just, J, Kalayci, O, Kaliner, Ma, Kauffmann, F, Kerkhof, M, Khayat, G, Koffi N'Goran, B, Kogevinas, M, Koppelman, Gh, Kowalski, Ml, Kull, I, Kuna, P, Larenas, D, Lavi, I, Le, Lt, Lieberman, P, Lipworth, B, Mahboub, B, Makela, Mj, Martin, F, Martinez, Fd, Marshall, Gd, Mazon, A, Melen, E, Meltzer, Eo, Mihaltan, F, Mohammad, Y, Mohammadi, A, Momas, I, Morais Almeida, M, Mullol, J, Muraro, A, Naclerio, R, Nafti, S, Namazova Baranova, L, Nawijn, Mc, Nyembue, Td, Oddie, S, O'Hehir, Re, Okamoto, Y, Orru, Mp, Ozdemir, C, Ouedraogo, Gs, Palkonen, S, Panzner, P, Passalacqua, G, Pawankar, R, Pigearias, B, Pin, I, Pinart, M, Pison, C, Popov, Ta, Porta, D, Postma, Ds, Price, D, Rabe, Kf, Ratomaharo, J, Reitamo, S, Rezagui, D, Ring, J, Roberts, R, Roca, J, Rogala, B, Romano, A, Rosado Pinto, J, Ryan, D, Sanchez Borges, M, Scadding, Gk, Sheikh, A, Simons, Fe, Siroux, V, Schmid Grendelmeier PD, Smit, Ha, Sooronbaev, T, Stein, Rt, Sterk, Pj, Sunyer, J, Terreehorst, I, Toskala, E, Tremblay, Y, Valenta, R, Valeyre, D, Vandenplas, O, van Weel, C, Vassilaki, M, Varraso, R, Viegi, G, Wang, Dy, Wickman, M, Williams, D, Wöhrl, S, Wright, J, Yorgancioglu, A, Yusuf, Om, Zar, Hj, Zernotti, Me, Zidarn, M, Zhong, N, Zuberbier, T., Beghe', B., Fthenou, E., Boudier, Anne, Hôpital Arnaud de Villeneuve [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), IMIM-Hospital del Mar, Generalitat de Catalunya, Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, CIBER Epidemiologia y Salud Publica, CIBER de Epidemiología y Salud Pública (CIBERESP), Universitat Pompeu Fabra [Barcelona] (UPF), WHO Collaborating Center for Asthma and Rhinitis, Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Pharmacoepidemiologie et évaluation de l'impact des produits de santé sur les populations, Université Bordeaux Segalen - Bordeaux 2-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Clinical Epidemiology and Biostatistics and Medicine, McMaster University [Hamilton, Ontario], National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), National Institutes of Health [Bethesda] (NIH), Swiss Institute of Allergy and Asthma Research (SIAF), Universität Zürich [Zürich] = University of Zurich (UZH), Génomique fonctionnelle et biologie systémique pour la santé, Institut des Sciences Biologiques du CNRS, Upper Airway Research Laboratory (URL), Ghent University Hospital, Department of Dermatology and Allergy, VU University Medical Center [Amsterdam], Department of Paediatrics, University of Oslo (UiO)-Oslo University Hospital [Oslo], Division of Allergy and Immunology, Department of Medicine, Creighton University, ProAR - FMB, Federal University of Bahia School of Medicine, Epidemiology and Health Economics, Instittute of Social Health-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Department of Dermatology, Medical School-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Division of Respiratory Medicine and Allergology, Teikyo University School of Medicine, Allergy Department, 2nd Pediatric Clinic, Son Pisa Primary Care Centre, IB-Salut Balearic Health Service, Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw - Poland-Faculté de Pharmacie de Paris, Department of Allergy and Clinical Immunology, Faculty of Medicine-Transylvania University, Public Hospital Medical Service, Ministry of Health [Mozambique], Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Center for Public Health Research (CSISP), University of Valencia, Respiratory Medicine, Università degli studi di Genova = University of Genoa (UniGe)-School of Specialization, Faculty of Medicine, Catholic University, Health Sciences Faculty, University of Cape Town, Department of Pulmonology, University of Amsterdam [Amsterdam] (UvA)-Academic Medical Centre, Divisions of Human Genetics Infection, Inflammation and Repair, University of Southampton-School of Medicine, Service de Pneumologie Allergologie, Hôpital La Rabta [Tunis], Service de Pneumologie, Hôpital Abderrahmen Mami, National Asthma Centre, National Institute of Diseases of the Chest and Hospital (NIDCH), Pneumologie / Anesthésie - réanimation / Oxygénothérapie, Hôpital AKS Phnom Penh-Hôpital Provincial de Siemreap, Department of Dermatology and Allergy Center, Odense University Hospital, Center for Genomics and Personalized Medicine, Wake Forest University, Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II = Università degli studi di Napoli Federico II, Università degli studi di Verona = University of Verona (UNIVR), Institut de cardiologie et de pneumologie, Université Laval [Québec] (ULaval)-Centre Hospitalier de Laval (CH Laval), Department of Respiratory Medicine and Thoracic Surgery, University of Leicester-Institute for Lung Health, Department of Paediatric Respiratory Medicine, Imperial College London-Royal Brompton Hospital-National Heart and Lung Institute [UK], Department of Medicine, University of Wisconsin School of Medicine and Public Health, Department of Pediatrics, Universidade Federal de Minas Gerais [Belo Horizonte] (UFMG)-Medical School, Allergy & Respiratory Diseases, Università degli studi di Genova = University of Genoa (UniGe)-Department of Internal Medicine (DIMI), Allergy & Asthma Associates, University of California [Irvine] (UC Irvine), University of California (UC)-University of California (UC), Deputy Scientific Director, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Pisana, Department of Thoracic Surgery, Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), National Cooperative Group of Pediatric Research on Asthma, Asthma Clinic and Education Center of the Capital Institute of Pediatrics, Service des Premiers Soins, Université Montpellier 1 (UM1), Osteopathic College of Medicine, Nova Southeastern University (NSU), Respiratory Research Group, University of Manchester [Manchester]-School of Translational Medicine, Department of Respiratory Diseases, Aarhus University Hospital, Department of Dermatology and Allergy Biederstein, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Service de pneumologie, Centre hospitalier de la région d'Annecy, Service de pneumo-allergologie, Centre Hospitalo-Universitaire de Béni-Messous, Allergy Centre, Vilnius University Antakalnis Hospital, Société Marocaine des Maladies Respiratoires, Centre of Respiratory Diseases and Allergy-Centre commercial Nadia, Allergy Division, Hospital S. João-Centre for Research in Health Technologies and Information Systems (CINTESIS)-Biostatistics and Medical Informatics Department-Porto University Medical School, Department of Otorhinolaryngology, Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA)-University of Amsterdam [Amsterdam] (UvA), Department of Social Medicine, University of Crete [Heraklion] (UOC)-Faculty of Medicine, Health Care, Minister Of Labour-Ministry of Labor, Health and Social Affairs, Section of Allergology, Erasmus Medical Centre, Epidemiology and Biostatistics Division, University of Arizona-Associate Research Scientist, Respiratory Sciences-Arizona Respiratory Center, Helsinki University Hospital-Skin and Allergy Hospital, Centre Hospitalier de Bigorre [Tarbes]-Association Franco-Libanaise de Pneumologie (AFLP), Department of Otorhinolaryngology, Head, and Neck Surgery, University Hospital Leuven, Engineering and the Environment, University of Southampton, Paediatrics and Child Health, University College Cork (UCC), Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de l'Asthme et des Allergies [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Pediatric Allergy and Asthma Unit, Ihsan Dogramaci Children's Hospital-Hacettepe University School of Medicine, Institute for Asthma and Allergy, George Washington University Medical School, Department of Epidemiology, University of Groningen [Groningen]-University Medical Center Groningen [Groningen] (UMCG)-Groningen Research Institute for Asthma and COPD (GRIAC), Université Saint-Joseph de Beyrouth (USJ)-Faculté de Médecine-Hôtel-Dieu de France, Service des Maladies Respiratoires, CHU de Cocody-UFR des Sciences Médicales, Pediatric Pulmonology, Allergology & Epidemiology, University of Groningen [Groningen]-University Medical Center Groningen [Groningen] (UMCG)-Beatrix Children's Hospital-Groningen Research Institute for Asthma and COPD, Department of Clinical Immunology and Allergy, Medical University of Łódź (MUL)-Faculty ot Medicine, Centre for Allergy Research, Karolinska Institutet [Stockholm], Department of Clinical Science and Education, Division of Internal Medicine, Asthma and Allergy, Medical University of Łódź (MUL)-Barlicki University Hospital, Hospital Medica Sur, Physiology Department, University of Medicine and Pharmacy, Division of Allergy Immunology, Department of Medicine-The University of Tennessee Health Science Center [Memphis] (UTHSC), university of dundee asthma - allergic rhinitis - COPD - beta-2-adrenoceptor, University of Dundee, Pulmonary and allergy unit, American University of Sharjah-Rashid Hospital-Dubai Health Authority (DHA), Association Franco-Vietnamienne de Pneumologie (AFVP), Centre Hospitalier de Compiègne (CHC), Arizona Respiratory Center, Department of Medicine, Clinical Immunology and Allergy, University of Mississippi Medical Center (UMMC), Institute of Environmental Medicine, Karolinska Institutet [Stockholm]-Karolinska University Hospital [Stockholm]-Astrid Lindgren Children's Hospital, Allergy & Asthma Medical Group & Research Center, University of California [San Diego] (UC San Diego), Pneumology Department, Marius Nasta Institute of Pneumology, Department of Internal Medicine, Tishreen University School of Medicine, Association Franco-Marocaine de Pathologie Thoracique (AFMAPATH), Collège National des Pneumologues Marocains, Epidémiologie Environnementale : Impact Sanitaire des Pollutions (EA 4064), Université Paris Descartes - Paris 5 (UPD5), Immunoallergy Department, Hospital CUF Descobertas, Rhinology Unit & Smell Clinic, Universitat de Barcelona (UB)-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Department of Medicine-Hospital Clinic-ENT Department, Allergy Unit, Università degli Studi di Padova = University of Padua (Unipd)-Department of Paediatrics, Section of Otolaryngology-Head & Neck Surgery (OHNS), University of Chicago, Clinique des maladies respiratoires, centre hospitalo-universitaire Mustapha Pacha d'Alger (CHUMA), Scientific Center for Children's Health, Russian Academy of Medical Sciences (RAMS), Laboratory of Allergology and Pulmonary Diseases, University of Groningen [Groningen]-University Medical Center Groningen [Groningen] (UMCG)-Department of Pathology and Medical Biology-GRIAC Research Institute, ENT Department, University of Kinshasa (UNIKIN), Bradford Neonatology, Bradford Teaching Hospitals NHS Foundation Trust-Bradford Institute for Health Research, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital-Monash University Building, AMREP, Chiba University Hospital, Asthme Rhinite allergique, Pharmacie, Division of Pediatric Allergy and Immunology, marmara university, Pédiatrie, Centre Hospitalier National Pédiatrique Charles de Gaulle (CHNP-CDG), European Federation of Allergy (EFA), Airways Diseases Patients' Associations, Department of Allergology and Clinical Immunology, Charles University [Prague] (CU)-Medical Faculty in Pilsen, Immunopharmacology, Nippon Medical School-Medical Research Council Clinical, Laboratoire du Sommeil et de l'Effort, Société de Pneumologie de Langue Française (SPLF)-Clinique St George, Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Clinic of Allergy and Asthma, Medical University Sofia-Alexander's University Hospital, Regional Health Service - Lazio, Primary Care Respiratory Medicine, University of Aberdeen-Department of General Practice and Primary Care-General Practice Airways Group (GPIAG), Department of Pulmonary Medicine, Leiden University Medical Center (LUMC), Pneumalgia, Centre Hospitalier Regional-Espace Francophone de Pneumologie (EFP)-Société de Pneumologie de l'Océan Indien (SPOI), Association Franco-Algérienne de Pneumologie (AFAP), Espace Francophone de pneumologie de la SPLF, Department of Pneumology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clínic de Barcelona-Institut Clínic del Tórax (ICT)-CIBER de Enfermedades Respiratorias (CIBERES)-University of Barcelona, Allergology and Clinical Immunology, Medical University of Silesia (SUM)-Chair and Clinical Department of Internal Diseases, UCSC-Allergy Unit, Complesso Integrato Columbus-Department of Internal Medicine and Geriatrics, Hospital da Luz, Medical Centre, Woodbrook Medical Centre, Research Fellow, University of Aberdeen-Department of General Practice, Centro Médico Docente La Trinidad, Department of Pharmacology, University College of London [London] (UCL)-The Royal National Throat, Nose and Ear Hospital, Primary Care Research & Development, University of Edinburgh-Centre for Population Health Sciences, Section of Allergy & Clinical Immunology, University of Manitoba [Winnipeg]-Department of Pediatrics & Child Health, Allergy Unit - Department of Dermatology, Julius Center for Health Sciences and Primary Care, University Medical Center [Utrecht], National Centre of Cardiology and Internal Medicine, Ministry of Health Kyrgyz Republic, School of Medicine, Pontifícia Universidade Católica, Department of ENT and Pediatrics, Finnish Institute of Occupational Health, Department of Obstetrics and Gynaecology, Université Laval [Québec] (ULaval)-Faculty of Medicine, Christian Doppler Laboratory for Allergy Research, Medizinische Universität Wien = Medical University of Vienna-Division of Immunopathology-Department of Pathophysiology and Allergy Research-Center for Pathophysiology, Infectiology and Immunology, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Department of Chest Medicine, Mont-Godinne Hospital-Catholic University of Louvain de Mont-Godinne, Department of Primary and Community Care, Radboud University Medical Center [Nijmegen], Epidemiology Unit, National Research Council (CNR)-Institute of Biomedicine and Molecular Immunology (IBIM), Pulmonary Environmental Epidemiology Unit, CNR Institute of Clinical Physiology, Department of Otolaryngology, National University of Singapore (NUS)-Yong Loo Lin School of Medicine, Karolinska Institutet [Stockholm]-Sachs' Children's Hospital, GLP Analytical Facility, School of Pharmacy, Department of Dermatology Division of Immunology, Allergy and Infectious Diseases (DIAID), Medical University of Vienna (MUW), Celal Bayar University School of Medicine, Allergy and Asthma Clinics, The Allergy and Asthma Institute, Department of Paediatrics and Child Health, Respiratory and Allergic Diseases, University Clinic of Respiratory and Allergic Diseases Golnik, State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Diseases-Guangzhou Medical College, Secretary General of the Global Allergy and Asthma European Network (GA2LEN), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], In collaboration with the WHO Collaborating Center for Asthma and Rhinitis, University of Genoa (UNIGE)-School of Specialization, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II, University of Verona (UNIVR), Medical School-Federal University of Minas Gerais, University of Genoa (UNIGE)-Department of Internal Medicine (DIMI), University of California [Irvine] (UCI), University of California-University of California, Catholic University Rome, University of Amsterdam [Amsterdam] (UvA)-Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), Centre Hospitalier de Bigorre (Tarbes)-Association Franco-Libanaise de Pneumologie (AFLP), CUF-Descobertas Hospital, Universita degli Studi di Padova-Department of Paediatrics, Medical Faculty in Pilsen-Charles University in Prague - the First Faculty of Medicine, Centro Medico-Docente La Trinidad, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]-Instittute of Social Health, Department of Internal Medicine (DIMI)-University of Genoa (UNIGE), Medical University of Silesia-Chair and Clinical Department of Internal Diseases, Dermatology, Internal Medicine, Immunology, Hôpital Arnaud de Villeneuve, Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Centre de recherche en épidémiologie et santé des populations ( CESP ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Center for Research in Environmental Epidemiology ( CREAL ), Universitat Pompeu Fabra [Barcelona]-Catalunya ministerio de salud, Universitat Pompeu Fabra [Barcelona], WHO(OMS), Université Bordeaux Segalen - Bordeaux 2-Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), National Institute of Allergy and Infectious Diseases [Bethesda], National Institutes of Health ( NIH ), Swiss Institute of Allergy and Asthma Research ( SIAF ), University of Zürich [Zürich] ( UZH ), Upper Airway Research Laboratory ( URL ), University Medical Center, University of Oslo ( UiO ) -Oslo University Hospital, Charite-Universitatsmedizin Berlin [Berlin]-Instittute of Social Health, Medical School-Charité - University Medicine Berlin, Medical University of Warsaw-Faculté de Pharmacie de Paris, Ministry of Health, Epidémiologie des maladies infectieuses et modélisation ( ESIM ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Center for Public Health Research ( CSISP ), University of Genoa ( UNIGE ) -School of Specialization, University of Amsterdam [Amsterdam] ( UvA ) -Academic Medical Centre, University of Southampton [Southampton]-School of Medicine, Hôpital La Rabta [Tunis), Wake Forest University Health Sciences, CNR, Rome, Italy and Department of Medicine-Second University of Naples, Università degli Studi di Verona, Université Laval-l'Hôpital Laval, Imperial College London-Royal Brompton Hospital-National Heart and Lung Institute, University of Genoa ( UNIGE ) -Department of Internal Medicine (DIMI), Southern California Research, Université Montpellier 1 ( UM1 ), Nova Southeastern University, Technische Universität München [München] ( TUM ), Academic Medical Center [Amsterdam] ( AMC ), University of Amsterdam [Amsterdam] ( UvA ) -University of Amsterdam [Amsterdam] ( UvA ), University of Crete ( UOC ) -Faculty of Medicine, University of Southampton [Southampton], UUniversity College Cork - National University of Ireland, Cork (UCC), Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Antoine Béclère, Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Trousseau [APHP], University of Groningen [Groningen]-University Medical Center Groningen-Groningen Research Institute for Asthma and COPD (GRIAC), Université Saint-Joseph de Beyrouth ( USJ ) -Faculté de Médecine-Hôtel-Dieu de France, University of Groningen [Groningen]-University Medical Center Groningen-Beatrix Children's Hospital-Groningen Research Institute for Asthma and COPD, Medical University of Łódź ( MUL ) -Faculty ot Medicine, Medical University of Łódź ( MUL ) -Barlicki University Hospital, Department of Medicine-University of Tennessee College for Medicine, Association Franco-Vietnamienne de Pneumologie ( AFVP ), University of Mississippi Medical Center, University of California [San Diego] ( UC San Diego ), Association Franco-Marocaine de Pathologie Thoracique ( AFMAPATH ), Epidémiologie Environnementale : Impact Sanitaire des Pollutions ( EA 4064 ), Université Paris Descartes - Paris 5 ( UPD5 ), Universitat de Barcelona ( UB ) -Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Department of Medicine-Hospital Clinic-ENT Department, Section of Otolaryngology-Head & Neck Surgery ( OHNS ), University of Groningen [Groningen]-University Medical Center Groningen-Department of Pathology and Medical Biology-GRIAC Research Institute, University Hospital of Kinshasa, European Federation of Allergy ( EFA ), Institut d'oncologie/développement Albert Bonniot de Grenoble ( INSERM U823 ), Université Joseph Fourier - Grenoble 1 ( UJF ) -CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Bioenergétique fondamentale et appliquée ( LBFA ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Department of General Practice and Primary Care-General Practice Airways Group (GPIAG)-University of Aberdeen, Association Franco-Algérienne de Pneumologie ( AFAP ), Department of General Practice-University of Aberdeen, University College of London [London] ( UCL ) -The Royal National Throat, Nose and Ear Hospital, University Medical Center Utrecht, Faculty of Medicine-Laval University [Québec], Medical University of Vienna-Division of Immunopathology-Department of Pathophysiology and Allergy Research-Center for Pathophysiology, Infectiology and Immunology, Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Avicenne, National University of Singapore ( NUS ) -Yong Loo Lin School of Medicine, Department of Dermatology Division of Immunology, Allergy and Infectious Diseases ( DIAID ), Secretary General of the Global Allergy and Asthma European Network ( GA2LEN ), Network of Excellence, Charité - Universitätsmedizin Berlin, CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK (BIHR), Universiteit Leiden-Universiteit Leiden, and Medizinische Universität Wien = Medical University of Vienna

Subjects
MESH: Asthma, severity, MESH: Comorbidity, Comorbidity, Severity of Illness Index, urticaria, MESH : Chronic Disease, MESH: Practice Guidelines as Topic, MESH : Dermatitis, Atopic, MESH: Urticaria, risk, 216-31 [Rhinitis, atopy, allergen Int Arch Allergy Immunol. 2012,158(3)], atopic dermatitis, MESH : Rhinitis, MESH: Rhinitis, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, Effective primary care and public health [NCEBP 7], Immunoglobulin E - Asthma - Rhinitis - Rhinosinusitis - Urticaria - Atopic dermatitis, MESH : Practice Guidelines as Topic, Practice Guidelines as Topic, MESH : Comorbidity, MESH : Severity of Illness Index, IgE, MESH: Sinusitis, MESH : Urticaria, MESH: Hypersensitivity, macromolecular substances, MESH : Asthma, Dermatitis, Atopic, rhinitis, SDG 3 - Good Health and Well-being, MESH: Dermatitis, Atopic, MESH: Severity of Illness Index, Hypersensitivity, Humans, Sinusitis, rhinosinusitis, MESH : Hypersensitivity, MESH: Humans, MESH: Chronic Disease, MESH : Humans, Asthma, Atopic dermatitis, Immunoglobulin E, Rhinitis, Rhinosinusitis, Urticaria, asthma, allergy, MESH : Sinusitis, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Chronic Disease, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, control
Abstract

Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies. Copyright (C) 2012 S. Karger AG, Basel

Published
2012
Full Text
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38. Severe chronic allergic (and related) diseases: A uniform approach - A MeDALL - GA2 LEN - ARIA position paper

Author

Bousquet, J. Anto, J.M. Demoly, P. Schünemann, H.J. Togias, A. Akdis, M. Auffray, C. Bachert, C. Bieber, T. Bousquet, P.J. Carlsen, K.H. Casale, T.B. Cruz, A.A. Keil, T. Lodrup Carlsen, K.C. Maurer, M. Ohta, K. Papadopoulos, N.G. Roman Rodriguez, M. Samolinski, B. Agache, I. Andrianarisoa, A. Ang, C.S. Annesi-Maesano, I. Ballester, F. Baena-Cagnani, C.E. Basagaña, X. Bateman, E.D. Bel, E.H. Bedbrook, A. Beghé, B. Beji, M. Ben Kheder, A. Benet, M. Bennoor, K.S. Bergmann, K.C. Berrissoul, F. Bindslev Jensen, C. Bleecker, E.R. Bonini, S. Boner, A.L. Boulet, L.P. Brightling, C.E. Brozek, J.L. Bush, A. Busse, W.W. Camargos, P.A.M. Canonica, G.W. Carr, W. Cesario, A. Chen, Y.Z. Chiriac, A.M. Costa, D.J. Cox, L. Custovic, A. Dahl, R. Darsow, U. Didi, T. Dolen, W.K. Douagui, H. Dubakiene, R. El-Meziane, A. Fonseca, J.A. Fokkens, W.J. Fthenou, E. Gamkrelidze, A. Garcia-Aymerich, J. Van Wijk, R.G. Gimeno-Santos, E. Guerra, S. Haahtela, T. Haddad, H. Hellings, P.W. Hellquist-Dahl, B. Hohmann, C. Howarth, P. Hourihane, J.O. Humbert, M. Jacquemin, B. Just, J. Kalayci, O. Kaliner, M.A. Kauffmann, F. Kerkhof, M. Khayat, G. Koffi N'Goran, B. Kogevinas, M. Koppelman, G.H. Kowalski, M.L. Kull, I. Kuna, P. Larenas, D. Lavi, I. Le, L.T. Lieberman, P. Lipworth, B. Mahboub, B. Makela, M.J. Martin, F. Martinez, F.D. Marshall, G.D. Mazon, A. Melen, E. Meltzer, E.O. Mihaltan, F. Mohammad, Y. Mohammadi, A. Momas, I. Morais-Almeida, M. Mullol, J. Muraro, A. Naclerio, R. Nafti, S. Namazova-Baranova, L. Nawijn, M.C. Nyembue, T.D. Oddie, S. O'Hehir, R.E. Okamoto, Y. Orru, M.P. Ozdemir, C. Ouedraogo, G.S. Palkonen, S. Panzner, P. Passalacqua, G. Pawankar, R. Pigearias, B. Pin, I. Pinart, M. Pison, C. Popov, T.A. Porta, D. Postma, D.S. Price, D. Rabe, K.F. Ratomaharo, J. Reitamo, S. Rezagui, D. Ring, J. Roberts, R. Roca, J. Rogala, B. Romano, A. Rosado-Pinto, J. Ryan, D. Sanchez-Borges, M. Scadding, G.K. Sheikh, A. Simons, F.E.R. Siroux, V. Schmid-Grendelmeier, P.D. Smit, H.A. Sooronbaev, T. Stein, R.T. Sterk, P.J. Sunyer, J. Terreehorst, I. Toskala, E. Tremblay, Y. Valenta, R. Valeyre, D. Vandenplas, O. Van Weel, C. Vassilaki, M. Varraso, R. Viegi, G. Wang, D.Y. Wickman, M. Williams, D. Wöhrl, S. Wright, J. Yorgancioglu, A. Yusuf, O.M. Zar, H.J. Zernotti, M.E. Zidarn, M. Zhong, N. Zuberbier, T.

Subjects
macromolecular substances
Abstract

Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies. Copyright © 2012 S. Karger AG, Basel.

Published
2012

39. MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine

Author

Bousquet, J. Anto, J. Auffray, C. Akdis, M. and Cambon-Thomsen, A. Keil, T. Haahtela, T. Lambrecht, B. N. and Postma, D. S. Sunyer, J. Valenta, R. Akdis, C. A. and Annesi-Maesano, I. Arno, A. Bachert, C. Ballester, F. and Basagana, X. Baumgartner, U. Bindslev-Jensen, C. Brunekreef, B. Carlsen, K. H. Chatzi, L. Crameri, R. Eveno, E. and Forastiere, F. Garcia-Aymerich, J. Guerra, S. Hammad, H. and Heinrich, J. Hirsch, D. Jacquemin, B. Kauffmann, F. and Kerkhof, M. Kogevinas, M. Koppelman, G. H. Kowalski, M. L. and Lau, S. Lodrup-Carlsen, K. C. Lopez-Botet, M. Lotvall, J. Lupinek, C. Maier, D. Makela, M. J. Martinez, F. D. and Mestres, J. Momas, I. Nawijn, M. C. Neubauer, A. and Oddie, S. Palkonen, S. Pin, I. Pison, C. Rance, F. and Reitamo, S. Rial-Sebbag, E. Salapatas, M. Siroux, V. and Smagghe, D. Torrent, M. Toskala, E. van Cauwenberge, P. and van Oosterhout, A. J. M. Varraso, R. von Hertzen, L. and Wickman, M. Wijmenga, C. Worm, M. Wright, J. Zuberbier, T.

Abstract

P>The origin of the epidemic of IgE-associated (allergic) diseases is unclear. MeDALL (Mechanisms of the Development of ALLergy), an FP7 European Union project (No. 264357), aims to generate novel knowledge on the mechanisms of initiation of allergy and to propose early diagnosis, prevention, and targets for therapy. A novel phenotype definition and an integrative translational approach are needed to understand how a network of molecular and environmental factors can lead to complex allergic diseases. A novel, stepwise, large-scale, and integrative approach will be led by a network of complementary experts in allergy, epidemiology, allergen biochemistry, immunology, molecular biology, epigenetics, functional genomics, bioinformatics, computational and systems biology. The following steps are proposed: (i) Identification of ‘classical’ and ‘novel’ phenotypes in existing birth cohorts; (ii) Building discovery of the relevant mechanisms in IgE-associated allergic diseases in existing longitudinal birth cohorts and Karelian children; (iii) Validation and redefinition of classical and novel phenotypes of IgE-associated allergic diseases; and (iv) Translational integration of systems biology outcomes into health care, including societal aspects. MeDALL will lead to: (i) A better understanding of allergic phenotypes, thus expanding current knowledge of the genomic and environmental determinants of allergic diseases in an integrative way; (ii) Novel diagnostic tools for the early diagnosis of allergy, targets for the development of novel treatment modalities, and prevention of allergic diseases; (iii) Improving the health of European citizens as well as increasing the competitiveness and boosting the innovative capacity of Europe, while addressing global health issues and ethical issues.

Published
2011

41. Operative definition of active and healthy ageing (AHA): Meeting report. Montpellier October 20–21, 2014

Author

Bousquet, J., primary, Kuh, D., additional, Bewick, M., additional, Strandberg, T., additional, Farrell, J., additional, Pengelly, R., additional, Joel, M.E., additional, Rodriguez Mañas, L., additional, Mercier, J., additional, Bringer, J., additional, Camuzat, T., additional, Bourret, R., additional, Bedbrook, A., additional, Kowalski, M.L., additional, Samolinski, B., additional, Bonini, S., additional, Brayne, C., additional, Michel, J.P., additional, Venne, J., additional, Viriot-Durandal, P., additional, Alonso, J., additional, Avignon, A., additional, Bousquet, P.J., additional, Combe, B., additional, Cooper, R., additional, Hardy, R., additional, Iaccarino, G., additional, Keil, T., additional, Kesse-Guyot, E., additional, Momas, I., additional, Ritchie, K., additional, Robine, J.M., additional, Thijs, C., additional, Tischer, C., additional, Vellas, B., additional, Zaidi, A., additional, Alonso, F., additional, Andersen Ranberg, K., additional, Andreeva, V., additional, Ankri, J., additional, Arnavielhe, S., additional, Arshad, S.H., additional, Augé, P., additional, Berr, C., additional, Bertone, P., additional, Blain, H., additional, Blasimme, A., additional, Buijs, G.J., additional, Caimmi, D., additional, Carriazo, A., additional, Cesario, A., additional, Coletta, J., additional, Cosco, T., additional, Criton, M., additional, Cuisinier, F., additional, Demoly, P., additional, Fernandez-Nocelo, S., additional, Fougère, B., additional, Garcia-Aymerich, J., additional, Goldberg, M., additional, Guldemond, N., additional, Gutter, Z., additional, Harman, D., additional, Hendry, A., additional, Heve, D., additional, Illario, M., additional, Jeandel, C., additional, Krauss-Etschmann, S., additional, Krys, O., additional, Kula, D., additional, Laune, D., additional, Lehmann, S., additional, Maier, D., additional, Malva, J., additional, Matignon, P., additional, Melen, E., additional, Mercier, G., additional, Moda, G., additional, Nizinkska, A., additional, Nogues, M., additional, O’Neill, M., additional, Pelissier, J.Y., additional, Poethig, D., additional, Porta, D., additional, Postma, D., additional, Puisieux, F., additional, Richards, M., additional, Robalo-Cordeiro, C., additional, Romano, V., additional, Roubille, F., additional, Schulz, H., additional, Scott, A., additional, Senesse, P., additional, Slagter, S., additional, Smit, H.A., additional, Somekh, D., additional, Stafford, M., additional, Suanzes, J., additional, Todo-Bom, A., additional, Touchon, J., additional, Traver-Salcedo, V., additional, Van Beurden, M., additional, Varraso, R., additional, Vergara, I., additional, Villalba-Mora, E., additional, Wilson, N., additional, Wouters, E., additional, and Zins, M., additional

Published
2015
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49. Work related asthma. A causal analysis controlling the healthy worker effect

Author

Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Dumas, O., Le Moual, N., Siroux, V., Heederik, D., Garcia-Aymerich, J., Varraso, R., Kauffmann, F., Basagaña, X., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Dumas, O., Le Moual, N., Siroux, V., Heederik, D., Garcia-Aymerich, J., Varraso, R., Kauffmann, F., and Basagaña, X.

Published
2013

50. Severe chronic allergic (and related) diseases: a uniform approach--a MeDALL--GA2LEN--ARIA position paper.

Author

Bousquet, J., Anto, J.M., Demoly, P., Schunemann, H.J., Togias, A., Akdis, M., Auffray, C., Bachert, C., Bieber, T., Bousquet, P.J., Carlsen, K.H., Casale, T.B., Cruz, A.A., Keil, T., Lodrup Carlsen, K.C., Maurer, M., Ohta, K., Papadopoulos, N.G., Roman Rodriguez, M., Samolinski, B., Agache, I., Andrianarisoa, A., Ang, C.S., Annesi-Maesano, I., Ballester, F., Baena-Cagnani, C.E., Basagana, X., Bateman, E.D., Bel, E.H., Bedbrook, A., Beghe, B., Beji, M., Kheder, A. Ben, Benet, M., Bennoor, K.S., Bergmann, K.C., Berrissoul, F., Bindslev Jensen, C., Bleecker, E.R., Bonini, S., Boner, A.L., Boulet, L.P., Brightling, C.E., Brozek, J.L., Bush, A., Busse, W.W., Camargos, P.A., Canonica, G.W., Carr, W., Cesario, A., Chen, Y.Z., Chiriac, A.M., Costa, D.J., Cox, L., Custovic, A., Dahl, R., Darsow, U., Didi, T., Dolen, W.K., Douagui, H., Dubakiene, R., El-Meziane, A., Fonseca, J.A., Fokkens, W.J., Fthenou, E., Gamkrelidze, A., Garcia-Aymerich, J., Gerth van Wijk, R., Gimeno-Santos, E., Guerra, S., Haahtela, T., Haddad, H., Hellings, P.W., Hellquist-Dahl, B., Hohmann, C., Howarth, P., Hourihane, J.O., Humbert, M., Jacquemin, B., Just, J., Kalayci, O., Kaliner, M.A., Kauffmann, F., Kerkhof, M. van de, Khayat, G., Koffi N'Goran, B., Kogevinas, M., Koppelman, G.H., Kowalski, M.L., Kull, I., Kuna, P., Larenas, D., Lavi, I., Le, L.T., Lieberman, P., Lipworth, B., Mahboub, B., Makela, M.J., Martin, F., Martinez, F.D., Marshall, G.D., Fatima Mazon, A. di, Melen, E., Meltzer, E.O., Mihaltan, F., Mohammad, Y., Mohammadi, A., Momas, I., Morais-Almeida, M., Mullol, J., Muraro, A., Naclerio, R., Nafti, S., Namazova-Baranova, L., Nawijn, M.C., Nyembue, T.D., Oddie, S., O'Hehir, R.E., Okamoto, Y., Orru, M.P., Ozdemir, C., Ouedraogo, G.S., Palkonen, S., Panzner, P., Passalacqua, G., Pawankar, R., Pigearias, B., Pin, I., Pinart, M., Pison, C., Popov, T.A., Porta, D., Postma, D.S., Price, D., Rabe, K.F., Ratomaharo, J., Reitamo, S., Rezagui, D., Ring, J., Roberts, R., Roca, J., Rogala, B., Romano, A., Rosado-Pinto, J., Ryan, D., Sanchez-Borges, M., Scadding, G.K., Sheikh, A., Simons, F.E., Siroux, V., Schmid-Grendelmeier, P.D., Smit, H.A., Sooronbaev, T., Stein, R.T., Sterk, P.J., Sunyer, J., Terreehorst, I., Toskala, E., Tremblay, Y., Valenta, R., Valeyre, D., Vandenplas, O., Weel, C. van, Vassilaki, M., Varraso, R., Viegi, G., Wang, D.Y., Wickman, M., Williams, D., Wohrl, S., Wright, J., Yorgancioglu, A., Yusuf, O.M., Zar, H.J., Zernotti, M.E., Zidarn, M., Zhong, N., Zuberbier, T., Bousquet, J., Anto, J.M., Demoly, P., Schunemann, H.J., Togias, A., Akdis, M., Auffray, C., Bachert, C., Bieber, T., Bousquet, P.J., Carlsen, K.H., Casale, T.B., Cruz, A.A., Keil, T., Lodrup Carlsen, K.C., Maurer, M., Ohta, K., Papadopoulos, N.G., Roman Rodriguez, M., Samolinski, B., Agache, I., Andrianarisoa, A., Ang, C.S., Annesi-Maesano, I., Ballester, F., Baena-Cagnani, C.E., Basagana, X., Bateman, E.D., Bel, E.H., Bedbrook, A., Beghe, B., Beji, M., Kheder, A. Ben, Benet, M., Bennoor, K.S., Bergmann, K.C., Berrissoul, F., Bindslev Jensen, C., Bleecker, E.R., Bonini, S., Boner, A.L., Boulet, L.P., Brightling, C.E., Brozek, J.L., Bush, A., Busse, W.W., Camargos, P.A., Canonica, G.W., Carr, W., Cesario, A., Chen, Y.Z., Chiriac, A.M., Costa, D.J., Cox, L., Custovic, A., Dahl, R., Darsow, U., Didi, T., Dolen, W.K., Douagui, H., Dubakiene, R., El-Meziane, A., Fonseca, J.A., Fokkens, W.J., Fthenou, E., Gamkrelidze, A., Garcia-Aymerich, J., Gerth van Wijk, R., Gimeno-Santos, E., Guerra, S., Haahtela, T., Haddad, H., Hellings, P.W., Hellquist-Dahl, B., Hohmann, C., Howarth, P., Hourihane, J.O., Humbert, M., Jacquemin, B., Just, J., Kalayci, O., Kaliner, M.A., Kauffmann, F., Kerkhof, M. van de, Khayat, G., Koffi N'Goran, B., Kogevinas, M., Koppelman, G.H., Kowalski, M.L., Kull, I., Kuna, P., Larenas, D., Lavi, I., Le, L.T., Lieberman, P., Lipworth, B., Mahboub, B., Makela, M.J., Martin, F., Martinez, F.D., Marshall, G.D., Fatima Mazon, A. di, Melen, E., Meltzer, E.O., Mihaltan, F., Mohammad, Y., Mohammadi, A., Momas, I., Morais-Almeida, M., Mullol, J., Muraro, A., Naclerio, R., Nafti, S., Namazova-Baranova, L., Nawijn, M.C., Nyembue, T.D., Oddie, S., O'Hehir, R.E., Okamoto, Y., Orru, M.P., Ozdemir, C., Ouedraogo, G.S., Palkonen, S., Panzner, P., Passalacqua, G., Pawankar, R., Pigearias, B., Pin, I., Pinart, M., Pison, C., Popov, T.A., Porta, D., Postma, D.S., Price, D., Rabe, K.F., Ratomaharo, J., Reitamo, S., Rezagui, D., Ring, J., Roberts, R., Roca, J., Rogala, B., Romano, A., Rosado-Pinto, J., Ryan, D., Sanchez-Borges, M., Scadding, G.K., Sheikh, A., Simons, F.E., Siroux, V., Schmid-Grendelmeier, P.D., Smit, H.A., Sooronbaev, T., Stein, R.T., Sterk, P.J., Sunyer, J., Terreehorst, I., Toskala, E., Tremblay, Y., Valenta, R., Valeyre, D., Vandenplas, O., Weel, C. van, Vassilaki, M., Varraso, R., Viegi, G., Wang, D.Y., Wickman, M., Williams, D., Wohrl, S., Wright, J., Yorgancioglu, A., Yusuf, O.M., Zar, H.J., Zernotti, M.E., Zidarn, M., Zhong, N., and Zuberbier, T.

Abstract

Item does not contain fulltext, Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies.

Published
2012

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