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12. Impact of Community Based Nutrition Intervention in the Prevention and Control of Anaemia Among Reproductive Aged Women of India

Author

Khanna, Poonam, Kaur, Manmeet, Varma, Neelam, Sharma, Sadhna, Sehgal, Rakesh, Singh, Tarundeep, Srivastava, Rachana, Kushwaha, Savitesh, and Jain, Rachita

Subjects
Women -- Health aspects, Anemia -- Care and treatment -- Prevention, Community health services -- Services, Medical nutrition therapy -- Methods, Health care industry
Abstract

Introduction Maternal and child under-nutrition is particularly widespread in low and middle-income nations, increasing the overall disease burden due to poor nutritional status. The aim of this study was to develop nutrition intervention for the prevention and control of anaemia among women of reproductive age. Methods Community-based intervention study was conducted among 443 women of reproductive age group (15-49 years) to determine the effectiveness of a 6-month nutrition intervention package. The nutrition intervention was developed by using Precede-Proceed model and the trans-theoretical model of behavior change. Multi-channel communication approach was adopted and nutrition intervention package was provided. Assessment of haemoglobin, red blood cells, platelet, ferritin, folate, vitamin B12, haematocrit test, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, red cell distribution width and total leucocyte count was compared at the baseline and endline after the intervention among the participants. The chi-square test of independence and t-test were performed. Results The only mean ferritin level shows significant improvement (p < 0.001). A significant decrease (~ 15%, p = 0.027) in anaemia was observed after the intervention. Conclusions Improvement in anaemic status of women was observed. National schemes and programs require a more robust strategical implementation like food fortification/bio fortification and behaviour change communication at village level to enhance the availability and accessibility of fortified food., Author(s): Poonam Khanna [sup.1] , Manmeet Kaur [sup.1] , Neelam Varma [sup.1] , Sadhna Sharma [sup.1] , Rakesh Sehgal [sup.1] , Tarundeep Singh [sup.1] , Rachana Srivastava [sup.1] , Savitesh [...]

Published
2023
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18. Factors associated with thrombo-hemorrhagic deaths in patients with Acute Promyelocytic leukemia treated with Arsenic Trioxide and all-trans retinoic acid

Author

Singh, Charanpreet, Karunakaran, Parathan, Yanamandra, Uday, Jindal, Nishant, Kumar, Saloni Rani, Saini, Neha, Jandial, Aditya, Jain, Arihant, Lad, Deepesh, Prakash, Gaurav, Khadwal, Alka, Kumar, Narender, Naseem, Shano, Ahluwalia, Jasmina, Varma, Neelam, Varma, Subhash, and Malhotra, Pankaj

Published
2023
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19. A well curated cost-effective next generation sequencing panel identifies a diverse landscape of pathogenic and novel germline variants in bone marrow failure cohort in a resource constraint setting

Author

Pallavelangini, Swetha, Senguttuvan, Gnanamani, Bhatia, Prateek, Chhabra, Prashant, Singh, Minu, Khadwal, Alka, Jain, Arihant, Sharma, Pankaj, Thakur, Rozy, Sreedharanunni, Sreejesh, Bansal, Deepak, Jain, Richa, Peyam, Srinivasan, Mohapatra, Sonali, Jindal, Ankur, Suri, Deepti, Das, Reena, Varma, Neelam, Malhotra, Pankaj, and Trehan, Amita

Published
2023
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47. Randomized controlled trial of twice-daily versus alternate-day oral iron therapy in the treatment of iron-deficiency anemia

Author

Kaundal, Rahul, Bhatia, Prateek, Jain, Arihant, Jain, Ankur, Nampoothiri, Ram V., Mishra, Kundan, Jandial, Aditya, Goni, Deepak, Sandal, Rajeev, Jindal, Nishant, Meshram, Ashok, Sharma, Rintu, Khaire, Niranjan, Singh, Charanpreet, Khadwal, Alka, Prakash, Gaurav, Das, Reena, Varma, Neelam, Varma, Subhash, Malhotra, Pankaj, and Lad, Deepesh P.

Published
2020
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50. FLAER as a standalone reagent for paroxysmal nocturnal hemoglobinuria: Do we need to reconsider the guidelines for testing?

Author

Sharma, Praveen, Bose, Parveen, Mallik, Nabhajit, Gupta, Dikshat Gopal, Rachagiri, Suneel, Kumar, Arun, Kaur, Jasbir, Malhotra, Pankaj, Varma, Neelam, and Sachdeva, Man Updesh Singh

Subjects
HEMOLYTIC anemia diagnosis, FLOW cytometry, MEDICAL protocols, LEUCOCYTES, PEARSON correlation (Statistics), MONOCYTES, T-test (Statistics), CHEMICAL reagents, MANN Whitney U Test, DESCRIPTIVE statistics, MONOCLONAL antibodies, MEMBRANE glycoproteins, DATA analysis software, GRANULOCYTES
Abstract

Introduction: Flow cytometry‐based paroxysmal nocturnal hemoglobinuria (PNH) testing involves utilization of monoclonal antibodies against GPI‐linked proteins and FLAER. The ability of FLAER to bind to a wide variety of GPI‐linked structures and to be utilized across different leukocyte subsets is remarkable. We hypothesize that FLAER as a standalone reagent may be equally effective for detecting PNH clones. The present study intends to compare the results of a FLAER alone‐based strategy to the recommended FLAER+GPI‐linked protein‐based approach for applicability in clinical settings. Methods: EDTA‐anticoagulated blood samples from patients for PNH workup were tested for PNH by multiparametric flow cytometry. A conventional panel comprising gating markers (CD45 for WBC, CD15 for granulocytes, and CD64 for monocytes) and a combination of FLAER and GPI‐linked markers, such as CD24 and CD14, henceforth referred to as the "routine panel," was employed. Second, a "FLAER‐only panel" comprising the gating markers and FLAER alone (excluding the GPI‐linked markers CD24 and CD14) was set up. The samples were processed using the lyse‐wash‐stain‐wash technique, and events were acquired on BC Navios Ex flow cytometer (Beckman Coulter, Inc., USA) and analyzed on Kaluza Software 2.1. The presence of a PNH clone was reported at a value of ≥0.01%. Results: A total of 209 patients were tested. Both panels found a PNH clone in 20.1% of patients (n = 42/209) with a 100% concordance rate. The PNH clone range for granulocytes was 0.01%–89.68%, and for monocyte was 0.04%–96.09% in the routine panel. The range in the FLAER‐only panel for granulocytes was 0.01%–89.61%, and for monocytes, it was 0.01%–96.05%. Pearson correlation statistics revealed a significant correlation between the size of the PNH clone of granulocytes and monocytes among the two panels tested (granulocytes r = 0.9999, p < 0.0001, 95% CI = 0.9999 to 1.000; monocytes r = 0.9974, p < 0.0001, 95% CI = 0.9966–0.9980). Conclusion: Based on our results, FLAER as a standalone marker is specific and sensitive for identifying PNH clones in granulocytes and monocytes, even for high‐sensitivity PNH assay. The proposed "FLAER‐only panel" panel is efficient and cost‐effective for highly sensitive PNH testing in two different cell lineages, especially in resource‐limited clinical settings. [ABSTRACT FROM AUTHOR]

Published
2024
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