Search

Your search keyword '"Varkevisser, Rosanne"' showing total 25 results
Start Over Author "Varkevisser, Rosanne"
25 results on '"Varkevisser, Rosanne"'

1. Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo

Author

Baburin, Igor, Varkevisser, Rosanne, Schramm, Anja, Saxena, Priyanka, Beyl, Stanislav, Szkokan, Phillip, Linder, Tobias, Stary-Weinzinger, Anna, van der Heyden, Marcel A.G., Houtman, Marien, Takanari, Hiroki, Jonsson, Malin, Beekman, Jet H.D., Hamburger, Matthias, Vos, Marc A., and Hering, Steffen

Published
2018
Full Text
View/download PDF

8. Severe Bradycardia Increases the Incidence and Severity of Torsade de Pointes Arrhythmias by Augmenting Preexistent Spatial Dispersion of Repolarization in the CAVB Dog Model

Author

Medische Fysiologie, Circulatory Health, van Weperen, Valerie Y.H., Dunnink, Albert, Bossu, Alexandre, Beekman, Jet D.M., Meijborg, Veronique M.F., de Bakker, Jacques M.T., Coronel, Ruben, Varkevisser, Rosanne, van der Heyden, Marcel A.G., Vos, Marc A., Medische Fysiologie, Circulatory Health, van Weperen, Valerie Y.H., Dunnink, Albert, Bossu, Alexandre, Beekman, Jet D.M., Meijborg, Veronique M.F., de Bakker, Jacques M.T., Coronel, Ruben, Varkevisser, Rosanne, van der Heyden, Marcel A.G., and Vos, Marc A.

Published
2021

9. Severe Bradycardia Increases the Incidence and Severity of Torsade de Pointes Arrhythmias by Augmenting Preexistent Spatial Dispersion of Repolarization in the CAVB Dog Model

Author

van Weperen, Valerie Y. H., primary, Dunnink, Albert, additional, Bossu, Alexandre, additional, Beekman, Jet D. M., additional, Meijborg, Veronique M. F., additional, de Bakker, Jacques M. T., additional, Coronel, Ruben, additional, Varkevisser, Rosanne, additional, van der Heyden, Marcel A. G., additional, and Vos, Marc A., additional

Published
2021
Full Text
View/download PDF

11. Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia

Author

Bossu, Alexandre, Houtman, Marien J C, Meijborg, Veronique M F, Varkevisser, Rosanne, Beekman, Henriette D M, Dunnink, Albert, de Bakker, Jacques M T, Mollova, Nevena, Rajamani, Sridharan, Belardinelli, Luiz, van der Heyden, Marcel A G, Vos, Marc A, Cardiology, Amsterdam Cardiovascular Sciences, and ACS - Heart failure & arrhythmias

Subjects
Sulfonamides, Dogs, Dose-Response Relationship, Drug, Pyridines, Torsades de Pointes, Phenethylamines, Animals, Arrhythmias, Cardiac, Myocytes, Cardiac, Triazoles, Research Papers, Anti-Arrhythmia Agents, Research Paper
Abstract

BACKGROUND AND PURPOSE: Enhanced late sodium current (late INa ) in heart failure and long QT syndrome type 3 is proarrhythmic. This study investigated the antiarrhythmic effect and mode of action of the selective and potent late INa inhibitor GS-458967 (GS967) against Torsades de Pointes arrhythmias (TdP) in the chronic atrioventricular block (CAVB) dog. EXPERIMENTAL APPROACH: Electrophysiological and antiarrhythmic effects of GS967 were evaluated in isolated canine ventricular cardiomyocytes and CAVB dogs with dofetilide-induced early afterdepolarizations (EADs) and TdP, respectively. Mapping of intramural cardiac electrical activity in vivo was conducted to study effects of GS967 on spatial dispersion of repolarization. KEY RESULTS: GS967 (IC50 ~200nM) significantly shortened repolarization in canine ventricular cardiomyocytes and sinus rhythm (SR) dogs, in a concentration and dose-dependent manner. In vitro, despite addition of 1μM GS967, dofetilide-induced EADs remained present in 42% and 35% of cardiomyocytes from SR and CAVB dogs, respectively. Nonetheless, GS967 (787±265nM) completely abolished dofetilide-induced TdP in CAVB dogs (10/14 after dofetilide to 0/14 dogs after GS967), while single ectopic beats (sEB) persisted in 9 animals. In vivo mapping experiments showed that GS967 significantly reduced spatial dispersion of repolarization: cubic dispersion was significantly decreased from 237±54ms after dofetilide to 123±34ms after GS967. CONCLUSION AND IMPLICATIONS: GS967 terminated all dofetilide-induced TdP without completely suppressing EADs and sEB in vitro and in vivo, respectively. The antiarrhythmic mode of action of GS967, through the reduction of spatial dispersion of repolarization, seems to predominantly impede the perpetuation of arrhythmic events into TdP rather than their initiating trigger.

Published
2018

12. The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models

Author

Ji, Yuan, Varkevisser, Rosanne, Opacic, Dragan, Bossu, Alexandre, Kuiper, Marion, Beekman, Jet D.M., Yang, Sihyung, Khan, Azinwi Phina, Dobrev, Dobromir, Voigt, Niels, Wang, Michael Zhuo, Verheule, Sander, Vos, Marc A., van der Heyden, Marcel A.G., Fysiologie, RS: CARIM - R2.11 - Experimental atrial fibrillation, and Cardiologie

Subjects
Pharmacology, III DRUGS, Medizin, UP-REGULATION, HUMAN AFRICAN TRYPANOSOMIASIS, POTASSIUM CURRENT, ATRIOVENTRICULAR-BLOCK, cardiovascular system, Journal Article, CARDIAC REPOLARIZATION, TORSADES-DE-POINTES, IONIC MECHANISMS, TRANSMURAL CONDUCTION, CURRENT I-K1
Abstract

BACKGROUND AND PURPOSE The density of the inward rectifier current (I-K1) increases in atrial fibrillation (AF), shortening effective refractory period and thus promoting atrial re-entry. The synthetic compound pentamidine analogue 6 (PA-6) is a selective and potent I-K1 inhibitor. We tested PA-6 for anti-AF efficacy and potential proarrhythmia, using established models in large animals. EXPERIMENTAL APPROACH PA-6 was applied i.v. in anaesthetized goats with rapid pacing-induced AF and anaesthetized dogs with chronic atrio-ventricular (AV) block. Electrophysiological and pharmacological parameters were determined. KEY RESULTS PA-6 (2.5 mg.kg(-1) .10 min(-1)) induced cardioversion to sinus rhythm (SR) in 5/6 goats and prolonged AF cycle length. AF complexity decreased significantly before cardioversion. PA-6 accumulated in cardiac tissue with ratios between skeletal muscle : atrial muscle : ventricular muscle of approximately 1:8:21. In SR dogs, PA-6 peak plasma levels 10 min post infusion were 5.5 +/- 0.9 mu M, PA-6 did not induce significant prolongation of QTc and did not affect heart rate, PQ or QRS duration. In dogs with chronic AV block, PA-6 did not affect QRS but lengthened QTc during the experiment, but not chronically. PA-6 did not induce TdP arrhythmias in nine animals (0/9) in contrast to dofetilide (5/9). PA-6 (200 nM) inhibited I-K1, but not I-K,I-ACh,I- in human isolated atrial cardiomyocytes. CONCLUSION AND IMPLICATIONS PA-6 restored SR in goats with persistent AF and, in dogs with chronic AV block, prolonged QT intervals, without inducing TdP arrhythmias. Our results demonstrate cardiac safety and good anti-AF properties for PA-6.

Published
2017

13. Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia

Author

Medische Fysiologie, Circulatory Health, Bossu, Alexandre, Houtman, Marien J C, Meijborg, Veronique M F, Varkevisser, Rosanne, Beekman, Henriette D M, Dunnink, Albert, de Bakker, Jacques M T, Mollova, Nevena, Rajamani, Sridharan, Belardinelli, Luiz, van der Heyden, Marcel A G, Vos, Marc A, Medische Fysiologie, Circulatory Health, Bossu, Alexandre, Houtman, Marien J C, Meijborg, Veronique M F, Varkevisser, Rosanne, Beekman, Henriette D M, Dunnink, Albert, de Bakker, Jacques M T, Mollova, Nevena, Rajamani, Sridharan, Belardinelli, Luiz, van der Heyden, Marcel A G, and Vos, Marc A

Published
2018

14. Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo

Author

Medische Fysiologie, Circulatory Health, Baburin, Igor, Varkevisser, Rosanne, Schramm, Anja, Saxena, Priyanka, Beyl, Stanislav, Szkokan, Phillip, Linder, Tobias, Stary-Weinzinger, Anna, van der Heyden, Marcel A.G., Houtman, Marien, Takanari, Hiroki, Jonsson, Malin, Beekman, Jet H.D., Hamburger, Matthias, Vos, Marc A., Hering, Steffen, Medische Fysiologie, Circulatory Health, Baburin, Igor, Varkevisser, Rosanne, Schramm, Anja, Saxena, Priyanka, Beyl, Stanislav, Szkokan, Phillip, Linder, Tobias, Stary-Weinzinger, Anna, van der Heyden, Marcel A.G., Houtman, Marien, Takanari, Hiroki, Jonsson, Malin, Beekman, Jet H.D., Hamburger, Matthias, Vos, Marc A., and Hering, Steffen

Published
2018

15. Beat-to-beat variations in activation-recovery interval derived from the right ventricular electrogram can monitor arrhythmic risk under anesthetic and awake conditions in the canine chronic atrioventricular block model

Author

Medische Fysiologie, Team Onderzoek, Circulatory Health, Planningssecretariaat HCK, Team Medisch, Wijers, Sofieke C., Sprenkeler, David J., Bossu, Alexandre, Dunnink, Albert, Beekman, Jet D.M., Varkevisser, Rosanne, Hernández, Alfonso Aranda, Meine, Mathias, Vos, Marc A., Medische Fysiologie, Team Onderzoek, Circulatory Health, Planningssecretariaat HCK, Team Medisch, Wijers, Sofieke C., Sprenkeler, David J., Bossu, Alexandre, Dunnink, Albert, Beekman, Jet D.M., Varkevisser, Rosanne, Hernández, Alfonso Aranda, Meine, Mathias, and Vos, Marc A.

Published
2018

18. The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models

Author

Medische Fysiologie, Circulatory Health, Ji, Yuan, Varkevisser, Rosanne, Opacic, Dragan, Bossu, Alexandre, Kuiper, Marion, Beekman, Jet D.M., Yang, Sihyung, Khan, Azinwi Phina, Dobrev, Dobromir, Voigt, Niels, Wang, Michael Zhuo, Verheule, Sander, Vos, Marc A., van der Heyden, Marcel A.G., Medische Fysiologie, Circulatory Health, Ji, Yuan, Varkevisser, Rosanne, Opacic, Dragan, Bossu, Alexandre, Kuiper, Marion, Beekman, Jet D.M., Yang, Sihyung, Khan, Azinwi Phina, Dobrev, Dobromir, Voigt, Niels, Wang, Michael Zhuo, Verheule, Sander, Vos, Marc A., and van der Heyden, Marcel A.G.

Published
2017

19. Short-term variability of repolarization is superior to other repolarization parameters in the evaluation of diverse antiarrhythmic interventions in the chronic atrioventricular block dog

Author

Medische Fysiologie, Circulatory Health, Bossu, Alexandre, Varkevisser, Rosanne, Beekman, Henriette D.M., Houtman, Marien J C, Van Der Heyden, Marcel A.G., Vos, Marc A., Medische Fysiologie, Circulatory Health, Bossu, Alexandre, Varkevisser, Rosanne, Beekman, Henriette D.M., Houtman, Marien J C, Van Der Heyden, Marcel A.G., and Vos, Marc A.

Published
2017

20. Electrophysiological measurements that can explain and guide temporary accelerated pacing to avert (re)occurrence of torsade de pointes arrhythmias in the canine chronic atrioventricular block model

Author

Medische Fysiologie, Team Onderzoek, Circulatory Health, Researchbureau DHL, Team Medisch, Wijers, Sofieke C., Bossu, Alexandre, Dunnink, Albert, Beekman, Jet D.M., Varkevisser, Rosanne, Aranda Hernández, Alfonso, Meine, Mathias, Vos, Marc A., Medische Fysiologie, Team Onderzoek, Circulatory Health, Researchbureau DHL, Team Medisch, Wijers, Sofieke C., Bossu, Alexandre, Dunnink, Albert, Beekman, Jet D.M., Varkevisser, Rosanne, Aranda Hernández, Alfonso, Meine, Mathias, and Vos, Marc A.

Published
2017

Catalog

Books, media, physical & digital resources
See catalog results