1. [Estimation of in vitro Monclavit-1 virucide activity against influenza virus A (H5N1)].
- Author
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Loginova SIa, Borisevich SV, Borisevich GV, Bondarev VP, and Variukhin AV
- Subjects
- Animals, Antiviral Agents toxicity, Cell Line, Dogs, Influenza A Virus, H5N1 Subtype isolation & purification, Anti-Infective Agents, Local pharmacology, Antiviral Agents pharmacology, Influenza A Virus, H5N1 Subtype drug effects, Nylons pharmacology, Polyvinyls pharmacology
- Abstract
The virucide activity of Monclavit-1 against the influenza virus A/Chicken/Kurgan/2/Russia/05 (H5N1) was investigated in the MDCK cell culture. It was shown that at a temperature of 14.0 +/- 1.0 degrees C Monclavit-1 in a 20-fold dilution within an hour inactivated the cytopathic activity of the virus and the specific hemagglutinin generation by 100 and 87.5% respectively. In a 40-fold dilution it inactivated at the average by 50% both the cytopathic activity and the specific hemagglutinin generation. In an 80-fold dilution it inactivated the cytopathic activity at the average by 20%. In a 160-fold dilution it did not inactivate the pathogen. At a temperature of 25.0 +/- 1.0 degrees C Monclavit-1 inactivated the influenza virus A/Chicken/Kurgan/2/Russia/05 (H5N1) by 90.0% only in the highest concentration.
- Published
- 2010