1. Inter-individual responses to sprint interval training, a pilot study investigating interactions with the sirtuin system.
- Author
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Gray, Stuart R., Aird, Tom P., Farquharson, Andrew J., Horgan, Graham W., Fisher, Emily, Wilson, John, Hopkins, Gareth E., Anderson, Bradley, Ahmad, Syed A., Davis, Stuart R., and Drew, Janice E.
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ADIPOSE tissues , *HUMAN body composition , *COENZYMES , *GLUCOSE tolerance tests , *INSULIN resistance , *TRANSFERASES , *TRYPTOPHAN , *WEIGHT loss , *PILOT projects , *GENE expression profiling , *GLYCEMIC control - Abstract
Sprint interval training (SIT) is reported to improve blood glucose control and may be a useful public health tool. The sirtuins and associated genes are emerging as key players in blood glucose control. This study investigated the interplay between the sirtuin/NAD system and individual variation in insulin sensitivity responses after SIT in young healthy individuals. Before and after 4 weeks of SIT, body mass and fat percentage were measured and oral glucose tolerance tests performed in 20 young healthy participants (7 females). Blood gene expression profiles (all 7 mammalian sirtuin genes and 15 enzymes involved in conversion of tryptophan, bioavailable vitamin B3, and metabolic precursors to NAD). NAD/NADP was measured in whole blood. Significant reductions in body weight and body fat post-SIT were associated with altered lipid profiles, NAD/NADP, and regulation of components of the sirtuin/NAD system ( NAMPT, NMNAT1, CD38, and ABCA1). Variable improvements in measured metabolic health parameters were evident and attributed to different responses in males and females, together with marked inter-individual variation in responses of the sirtuin/NAD system to SIT. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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