34 results on '"Vargova, Veronika"'
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2. T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways
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Smith, Kathleen, Karimian Azari, Elnaz, LaMoia, Traci E., Hussain, Tania, Vargova, Veronika, Karolyi, Katalin, Veldhuis, Paula P., Arnoletti, Juan Pablo, de la Fuente, Sebastian G., Pratley, Richard E., Osborne, Timothy F., and Kyriazis, George A.
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- 2018
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3. Chronopotentiometric sensing of specific interactions between lysozyme and the DNA aptamer
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Ostatná, Veronika, Kasalová-Vargová, Veronika, Kékedy-Nagy, László, Černocká, Hana, and Ferapontova, Elena E.
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- 2017
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4. Electrochemical sensing of concanavalin A and ovalbumin interaction in solution
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Vargová, Veronika, Helma, Robert, Paleček, Emil, and Ostatná, Veronika
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- 2016
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5. Prednisone versus prednisone plus ciclosporin versus prednisone plus methotrexate in new-onset juvenile dermatomyositis: a randomised trial
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Ruperto, Nicolino, Pistorio, Angela, Oliveira, Sheila, Zulian, Francesco, Cuttica, Ruben, Ravelli, Angelo, Fischbach, Michel, Magnusson, Bo, Sterba, Gary, Avcin, Tadej, Brochard, Karine, Corona, Fabrizia, Dressler, Frank, Gerloni, Valeria, Apaz, Maria T, Bracaglia, Claudia, Cespedes-Cruz, Adriana, Cimaz, Rolando, Couillault, Gerard, Joos, Rik, Quartier, Pierre, Russo, Ricardo, Tardieu, Marc, Wulffraat, Nico, Bica, Blanca, Dolezalova, Pavla, Ferriani, Virginia, Flato, Berit, Bernard-Medina, Ana G, Herlin, Troels, Trachana, Maria, Meini, Antonella, Allain-Launay, Emma, Pilkington, Clarissa, Vargova, Veronika, Wouters, Carine, Angioloni, Simona, and Martini, Alberto
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- 2016
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6. Label-free electrochemical detection of singlet oxygen protein damage
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Vargová, Veronika, Giménez, Rodrigo E., Černocká, Hana, Trujillo, Diana Chito, Tulli, Fiorella, Zanini, Verónica I. Paz, Paleček, Emil, Borsarelli, Claudio D., and Ostatná, Veronika
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- 2016
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7. Absence of Arthritis as a Sign of Sine Syndrome in Still’s Disease in Adulthood
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Rovenský, Jozef, Vargová, Veronika, Masaryk, Pavol, Košková, Elena, Rovenský, Jozef, editor, Herold, Manfred, editor, and Vašáková, Martina, editor
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- 2014
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8. Effect of His6-tagging of anterior gradient 2 protein on its electro-oxidation
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Ostatná, Veronika, Vargová, Veronika, Hrstka, Roman, Ďurech, Michal, Vojtěšek, Bořivoj, and Paleček, Emil
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- 2014
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9. Complexation of cytochrome c with calixarenes incorporated into the lipid vesicles and supported membranes
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Garaiová, Zuzana, Mohsin, Muhammad Ali, Vargová, Veronika, Banica, Florinel-Gabriel, and Hianik, Tibor
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- 2012
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10. Novel surfactant C variant c.325–47_374del without response to hydroxychloroquine treatment
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Drobnakova, Simona, Vargova, Veronika, Smolova, Jana, Drencakova, Petra, Giertlova, Maria, Pisarcikova, Maria, and Barkai, László
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- 2024
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11. Additional file 2 of High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice
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Serrano, Joan, Smith, Kathleen R., Crouch, Audra L., Sharma, Vandana, Fanchao Yi, Vargova, Veronika, LaMoia, Traci E., Dupont, Lydia M., Vanida Serna, Fenfen Tang, Laisa Gomes-Dias, Blakeslee, Joshua J., Hatzakis, Emmanuel, Peterson, Scott N., Anderson, Matthew, Pratley, Richard E., and Kyriazis, George A.
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human activities - Abstract
Additional file 1: Figure S1. Participant inclusion flowchart. Figure S2. Longitudinal treatment effects glucose and hormonal excursions during an oral glucose challenge in humans. Figure S3. Treatment compliance and intestinal gene expression in mice. Figure S4. Pre-treatment comparisons of gut microbial diversity and composition (genus) in humans. Figure S5. Pre-treatment comparisons and treatment effects on gut microbial diversity and composition in humans. Figure S6. Pre-treatment comparisons of gut microbial diversity and composition (genus) in mice. Figure S7. Pre-treatment comparisons and treatment effects on gut microbial diversity and composition in mice. Figure S8. Pre-treatment fecal metabolomics in humans and mice. Figure S9. Experimental design of the human and mouse studies.
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- 2021
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12. Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis: analysis by the Pharmachild Safety Adjudication Committee
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Giancane, Gabriella, Swart, Joost F., Castagnola, Elio, Groll, Andreas H., Horneff, Gerd, Huppertz, Hans-Iko, Lovell, Daniel J., Wolfs, Tom, Herlin, Troels, Dolezalova, Pavla, Sanner, Helga, Susic, Gordana, Sztajnbok, Flavio, Maritsi, Despoina, Constantin, Tamas, Vargova, Veronika, Sawhney, Sujata, Rygg, Marite, Oliveira, Sheila K., Cattalini, Marco, Bovis, Francesca, Bagnasco, Francesca, Pistorio, Angela, Martini, Alberto, Wulffraat, Nico, Ruperto, Nicolino, Giancane, Gabriella, Swart, Joost F., Castagnola, Elio, Groll, Andreas H., Horneff, Gerd, Huppertz, Hans-Iko, Lovell, Daniel J., Wolfs, Tom, Herlin, Troels, Dolezalova, Pavla, Sanner, Helga, Susic, Gordana, Sztajnbok, Flavio, Maritsi, Despoina, Constantin, Tamas, Vargova, Veronika, Sawhney, Sujata, Rygg, Marite, Oliveira, Sheila K., Cattalini, Marco, Bovis, Francesca, Bagnasco, Francesca, Pistorio, Angela, Martini, Alberto, Wulffraat, Nico, and Ruperto, Nicolino
- Abstract
Background To derive a list of opportunistic infections (OI) through the analysis of the juvenile idiopathic arthritis (JIA) patients in the Pharmachild registry by an independent Safety Adjudication Committee (SAC). Methods The SAC (3 pediatric rheumatologists and 2 pediatric infectious disease specialists) elaborated and approved by consensus a provisional list of OI for use in JIA. Through a 5 step-procedure, all the severe and serious infections, classified as per MedDRA dictionary and retrieved in the Pharmachild registry, were evaluated by the SAC by answering six questions and adjudicated with the agreement of 3/5 specialists. A final evidence-based list of OI resulted by matching the adjudicated infections with the provisional list of OI. Results A total of 772 infectious events in 572 eligible patients, of which 335 serious/severe/very severe non-OI and 437 OI (any intensity/severity), according to the provisional list, were retrieved. Six hundred eighty-two of 772 (88.3%) were adjudicated as infections, of them 603/682 (88.4%) as common and 119/682 (17.4%) as OI by the SAC. Matching these 119 opportunistic events with the provisional list, 106 were confirmed by the SAC as OI, and among them infections by herpes viruses were the most frequent (68%), followed by tuberculosis (27.4%). The remaining events were divided in the groups of non-OI and possible/patient and/or pathogen-related OI. Conclusions We found a significant number of OI in JIA patients on immunosuppressive therapy. The proposed list of OI, created by consensus and validated in the Pharmachild cohort, could facilitate comparison among future pharmacovigilance studies.
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- 2020
13. Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis: Analysis by the Pharmachild Safety Adjudication Committee
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Immuno/reuma patientenzorg, Child Health, Infectieziekten patientenzorg, Infection & Immunity, Cluster B, Immuno/reuma onderzoek 1 (Vastert), Immunologie/Reumatologie, Regenerative Medicine and Stem Cells, Onderzoek, Giancane, Gabriella, Swart, Joost F., Castagnola, Elio, Groll, Andreas H., Horneff, Gerd, Huppertz, Hans Iko, Lovell, Daniel J., Wolfs, Tom, Herlin, Troels, Dolezalova, Pavla, Sanner, Helga, Susic, Gordana, Sztajnbok, Flavio, Maritsi, Despoina, Constantin, Tamas, Vargova, Veronika, Sawhney, Sujata, Rygg, Marite, Oliveira, Sheila K., Cattalini, Marco, Bovis, Francesca, Bagnasco, Francesca, Pistorio, Angela, Martini, Alberto, Wulffraat, Nico, Ruperto, Nicolino, Cuttica, Ruben, Garay, Stella Maris, Brunner, Jurgen, Emminger, Wolfgang, Appenzeller, Simone, Len, Claudio, Saad Magalhaes, Claudia, Telcharova-Mihaylovska, Albena, Harjacek, Miroslav, Jelusic, Marija, Estmann, Anne, Nielsen, Susan, Herrera Mora, Cristina, Gervais, Elisabeth, Koné-Paut, Isabelle, Quartier, Pierre, Foeldvari, Ivan, Lutz, Thomas, Minden, Kirsten, Tzaribachev, Nikolay, Trachana, Maria, Tsitsami, Elena, Vougiouka, Olga, Orban, Ilonka, Harel, Liora, Hashkes, Philip, Uziel, Yosef, Cimaz, Rolando, Civino, Adele, Consolini, Rita, D'Angelo, Gianfranco, De Benedetti, Fabrizio, Filocamo, Giovanni, Fueri, Elena, Gallizzi, Romina, Maggio, Maria Cristina, Magnolia, Maria Greca, Miniaci, Angela, Montin, Davide, Olivieri, Alma Nunzia, Pastore, Serena, Rigante, Donato, Zulian, Francesco, Rumba-Rozenfelde, Ingrida, Stanevicha, Valda, Panaviene, Violeta, Rodriguez Lozano, Ana Luisa, Rubio-Perez, Nadina, Vega Cornejo, Gabriel, Hoppenreijs, Esther, Kamphuis, Sylvia, Flato, Berit, Nordal, Ellen Berit, Abdwani, Reem, Miraval, Tatiana, Paz Gastanaga, Maria Eliana, Smolewska, Elzbieta, Ailioaie, Constantin, Cochino, Alexis Virgil, Laday, Matilda, Lazar, Calin, Alexeeva, Ekaterina, Chasnyk, Vyacheslav, Keltsev, Vladimir, Suwairi, Wafaa Mohammed Saad, Vijatov-Djuric, Gordana, Vojinovic, Jelena, Arkachaisri, Thaschawee, Koskova, Elena, Avcin, Tadej, Ally, Mahmood, Van Rensburg, Christa Janse, Louw, Ingrid, Lopez, Jordi Anton, Boteanu, Alina Lucica, Calvo Penades, Inmaculada, De Inocencio, Jaime, Mesa-Del-Castillo, Pablo, Moreno, Estefania, Remesal, Agustin, Hofer, Michael, Gok, Faysal, Ozen, Seza, Ramanan, Athimalaipet, Pallotti, Chiara, Villa, Luca, Immuno/reuma patientenzorg, Child Health, Infectieziekten patientenzorg, Infection & Immunity, Cluster B, Immuno/reuma onderzoek 1 (Vastert), Immunologie/Reumatologie, Regenerative Medicine and Stem Cells, Onderzoek, Giancane, Gabriella, Swart, Joost F., Castagnola, Elio, Groll, Andreas H., Horneff, Gerd, Huppertz, Hans Iko, Lovell, Daniel J., Wolfs, Tom, Herlin, Troels, Dolezalova, Pavla, Sanner, Helga, Susic, Gordana, Sztajnbok, Flavio, Maritsi, Despoina, Constantin, Tamas, Vargova, Veronika, Sawhney, Sujata, Rygg, Marite, Oliveira, Sheila K., Cattalini, Marco, Bovis, Francesca, Bagnasco, Francesca, Pistorio, Angela, Martini, Alberto, Wulffraat, Nico, Ruperto, Nicolino, Cuttica, Ruben, Garay, Stella Maris, Brunner, Jurgen, Emminger, Wolfgang, Appenzeller, Simone, Len, Claudio, Saad Magalhaes, Claudia, Telcharova-Mihaylovska, Albena, Harjacek, Miroslav, Jelusic, Marija, Estmann, Anne, Nielsen, Susan, Herrera Mora, Cristina, Gervais, Elisabeth, Koné-Paut, Isabelle, Quartier, Pierre, Foeldvari, Ivan, Lutz, Thomas, Minden, Kirsten, Tzaribachev, Nikolay, Trachana, Maria, Tsitsami, Elena, Vougiouka, Olga, Orban, Ilonka, Harel, Liora, Hashkes, Philip, Uziel, Yosef, Cimaz, Rolando, Civino, Adele, Consolini, Rita, D'Angelo, Gianfranco, De Benedetti, Fabrizio, Filocamo, Giovanni, Fueri, Elena, Gallizzi, Romina, Maggio, Maria Cristina, Magnolia, Maria Greca, Miniaci, Angela, Montin, Davide, Olivieri, Alma Nunzia, Pastore, Serena, Rigante, Donato, Zulian, Francesco, Rumba-Rozenfelde, Ingrida, Stanevicha, Valda, Panaviene, Violeta, Rodriguez Lozano, Ana Luisa, Rubio-Perez, Nadina, Vega Cornejo, Gabriel, Hoppenreijs, Esther, Kamphuis, Sylvia, Flato, Berit, Nordal, Ellen Berit, Abdwani, Reem, Miraval, Tatiana, Paz Gastanaga, Maria Eliana, Smolewska, Elzbieta, Ailioaie, Constantin, Cochino, Alexis Virgil, Laday, Matilda, Lazar, Calin, Alexeeva, Ekaterina, Chasnyk, Vyacheslav, Keltsev, Vladimir, Suwairi, Wafaa Mohammed Saad, Vijatov-Djuric, Gordana, Vojinovic, Jelena, Arkachaisri, Thaschawee, Koskova, Elena, Avcin, Tadej, Ally, Mahmood, Van Rensburg, Christa Janse, Louw, Ingrid, Lopez, Jordi Anton, Boteanu, Alina Lucica, Calvo Penades, Inmaculada, De Inocencio, Jaime, Mesa-Del-Castillo, Pablo, Moreno, Estefania, Remesal, Agustin, Hofer, Michael, Gok, Faysal, Ozen, Seza, Ramanan, Athimalaipet, Pallotti, Chiara, and Villa, Luca
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- 2020
14. High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice
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Serrano, Joan, primary, Smith, Kathleen R., additional, Crouch, Audra L., additional, Sharma, Vandana, additional, Yi, Fanchao, additional, Vargova, Veronika, additional, LaMoia, Traci E., additional, Dupont, Lydia M., additional, Serna, Vanida, additional, Tang, Fenfen, additional, Gomes-Dias, Laisa, additional, Blakeslee, Joshua J., additional, Hatzakis, Emmanuel, additional, Peterson, Scott N., additional, Anderson, Matthew, additional, Pratley, Richard E., additional, and Kyriazis, George A., additional
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- 2021
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15. Juvenile Idiopathic Arthritis: Roma Children Seem to Run More Risk than Non-Roma
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Drobnakova, Simona, primary, Madarasova Geckova, Andrea, additional, Vargova, Veronika, additional, Schusterova, Ingrid, additional, Rosenberger, Jaroslav, additional, Klein, Daniel, additional, P van Dijk, Jitse, additional, and Reijneveld, Sijmen A., additional
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- 2020
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16. High dose saccharin supplementation does not induce gut microbiota dysbiosis or glucose intolerance in healthy humans and mice
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Serrano, Joan, primary, Smith, Kathleen R, additional, Crouch, Audra L, additional, Sharma, Vandana, additional, Yi, Fanchao, additional, Vargova, Veronika, additional, LaMoia, Traci E, additional, Dupont, Lydia M, additional, Serna, Vanida, additional, Tang, Fenfen, additional, Gomes-Dias, Laisa, additional, Blakeslee, Joshua, additional, Hatzakis, Emmanuel, additional, Peterson, Scott N, additional, Anderson, Matthew, additional, Pratley, Richard E, additional, and Kyriazis, George, additional
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- 2020
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17. Definition and Validation of the American College of Rheumatology 2021 Juvenile Arthritis Disease Activity Score Cutoffs for Disease Activity States in Juvenile Idiopathic Arthritis.
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Trincianti, Chiara, Van Dijkhuizen, Evert Hendrik Pieter, Alongi, Alessandra, Mazzoni, Marta, Swart, Joost F., Nikishina, Irina, Lahdenne, Pekka, Rutkowska‐Sak, Lidia, Avcin, Tadej, Quartier, Pierre, Panaviene, Violeta, Uziel, Yosef, Pruunsild, Chris, Vargova, Veronika, Vilaiyuk, Soamarat, Dolezalova, Pavla, Ringold, Sarah, Garrone, Marco, Ruperto, Nicolino, and Ravelli, Angelo
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RESEARCH methodology evaluation ,RESEARCH methodology ,JUVENILE idiopathic arthritis ,PREDICTIVE validity - Abstract
Objective: To develop and validate new Juvenile Arthritis Disease Activity Score 10 (JADAS10) and clinical JADAS10 (cJADAS10) cutoffs to separate the states of inactive disease (ID), minimal disease activity (MiDA), moderate disease activity (MoDA), and high disease activity (HDA) in children with oligoarthritis and with rheumatoid factor–negative polyarthritis, based on subjective disease assessment by the treating pediatric rheumatologist. Methods: The cutoffs definition cohort was composed of 1,936 patients included in the multinational Epidemiology, Treatment and Outcome of Childhood Arthritis (EPOCA) study. Using the subjective physician rating as an external criterion, 4 methods were applied to identify the cutoffs: mapping, Youden index, 90% specificity, and maximum agreement. The validation cohort included 4,014 EPOCA patients, patients from 2 randomized trials, and 88 patients from the PharmaChild registry. Cutoff validation was conducted by assessing discriminative and predictive ability. Results: The JADAS10 cutoffs were 1.4, 4, and 13, respectively, for oligoarthritis and 2.7, 6, and 17, respectively, for polyarthritis. The cJADAS10 cutoffs were 1.1, 4, and 12, respectively, for oligoarthritis and 2.5, 5, and 16, respectively, for polyarthritis. The cutoffs discriminated strongly among different levels of pain and morning stiffness, between patients who were and those who were not prescribed a new medication, and between different levels of improvement in clinical trials. Achievement of ID and MiDA according to the new JADAS cutoffs at least twice in the first year of disease predicted better outcome at 2 years. Conclusion: The 2021 JADAS and cJADAS cutoffs revealed good metrologic properties in both definition and validation samples, and are therefore suitable for use in clinical trials and routine practice. [ABSTRACT FROM AUTHOR]
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- 2021
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18. Phenotypic variability and disparities in treatment and outcomes of childhood arthritis throughout the world: an observational cohort study
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Consolaro, Alessandro, primary, Giancane, Gabriella, additional, Alongi, Alessandra, additional, van Dijkhuizen, Evert Hendrik Pieter, additional, Aggarwal, Amita, additional, Al-Mayouf, Sulaiman M, additional, Bovis, Francesca, additional, De Inocencio, Jaime, additional, Demirkaya, Erkan, additional, Flato, Berit, additional, Foell, Dirk, additional, Garay, Stella Maris, additional, Lazăr, Călin, additional, Lovell, Daniel J, additional, Montobbio, Carolina, additional, Miettunen, Paivi, additional, Mihaylova, Dimitrina, additional, Nielsen, Susan, additional, Orban, Ilonka, additional, Rumba-Rozenfelde, Ingrida, additional, Magalhães, Claudia Saad, additional, Shafaie, Nahid, additional, Susic, Gordana, additional, Trachana, Maria, additional, Wulffraat, Nico, additional, Pistorio, Angela, additional, Martini, Alberto, additional, Ruperto, Nicolino, additional, Ravelli, Angelo, additional, Abdwani, Reem, additional, Aghighi, Yahya, additional, Aiche, Maya-Feriel, additional, Ailioaie, Constantin, additional, Aktay Ayaz, Nuray, additional, Al-Abrawi, Safiya, additional, Alexeeva, Ekaterina, additional, Anton, Jordi, additional, Apostol, Adriana, additional, Arguedas, Olga, additional, Avcin, Tadej, additional, Barone, Patrizia, additional, Berntson, Lillemor, additional, Boteanu, Alina Lucica, additional, Boyko, Yaryna, additional, Burgos-Vargas, Ruben, additional, Calvo Penades, Inmaculada, additional, Chédeville, Gaëlle, additional, Cimaz, Rolando, additional, Civino, Adele, additional, Consolini, Rita, additional, Constantin, Tamas, additional, Cuttica, Ruben, additional, Dallos, Tomas, additional, Martin, Neil, additional, Magni Manzoni, Silvia, additional, De Cunto, Carmen, additional, Dolezalova, Pavla, additional, Ekelund, Maria, additional, El Miedany, Yasser, additional, Espada, Graciela, additional, Estmann Christensen, Anne, additional, Foeldvari, Ivan, additional, Gallizzi, Romina, additional, Ganser, Gerd, additional, Gerloni, Valeria, additional, Haas, Johannes-Peter, additional, Harel, Liora, additional, Harjacek, Miroslav, additional, Hashad, Soad, additional, Herlin, Troels, additional, Herrera, Cristina, additional, Hofer, Michael, additional, Holzinger, Dirk, additional, Horneff, Gerd, additional, Huppertz, Hans-Iko, additional, Iagăru, Nicolae, additional, Ibanez Estrella, Amparo, additional, Ioseliani, Maka, additional, Joos, Rik, additional, Knupp Oliveira, Sheila, additional, Kamphuis, Sylvia, additional, Kasapcopur, Ozgur, additional, Katsicas, Maria Martha, additional, Khubchandani, Raju, additional, Kondi, Anuela, additional, Kröger, Liisa, additional, La Torre, Francesco, additional, Laday, Matilda, additional, Lahdenne, Pekka, additional, Maggio, Maria Cristina, additional, Magnolia, Maria Greca, additional, Malagon, Clara, additional, Malin, Merja, additional, Martino, Silvana, additional, Melo-Gomes, Jose Antonio, additional, Mesa-del-Castillo, Pablo, additional, Militaru, Andrea, additional, Minden, Kirsten, additional, Miniaci, Angela, additional, Moradinejad, Mohammad Hasan, additional, Morel Ayala, Zoilo, additional, Nikishina, Irina, additional, Norambuena, Ximena, additional, Nordal, Ellen Berit, additional, Pagava, Karaman, additional, Panaviene, Violeta, additional, Pastore, Serena, additional, Pieropan, Sara, additional, Podda, Rosa Anna, additional, Pruunsild, Chris, additional, Putto-Laurila, Anne, additional, Quartier, Pierre, additional, Remesal, Agustin, additional, Rigante, Donato, additional, Ringold, Sarah, additional, Rutkowska-Sak, Lidia, additional, Rygg, Marite, additional, Saurenmann, Rotraud Katharina, additional, Sawhney, Sujata, additional, Scott, Christiaan, additional, Shiari, Reza, additional, Smolewska, Elzbieta, additional, Sozeri, Betul, additional, Swart, Joost Frans, additional, Sztajnbok, Flavio, additional, Torcoletti, Marta, additional, Tsitsami, Elena, additional, Tzaribachev, Nikolay, additional, Unsal, Erbil, additional, Uziel, Yosef, additional, Vähäsalo, Paula, additional, Varbanova, Boriana, additional, Vargova, Veronika, additional, Vesely, Richard, additional, Vijatov-Djuric, Gordana, additional, Vilaiyuk, Soamarat, additional, Vojinovic, Jelena, additional, Vougiouka, Olga, additional, Weiss, Pamela, additional, and Wouters, Carine, additional
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- 2019
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19. Development of New Juvenile Arthritis Disease Activity Score Cut-Offs for Oligoarthritis and RF-Negative Polyarthritis from a Large Multinational Cohort of Children with Juvenile Idiopathic Arthritis
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Consolaro, Alessandro, Dijkhuizen, Pieter, Espada, Graciela, Varbanova, Boriana, Oliveira, Sheila, Miettunen, Paivi, Chedeville, Gaelle, Hofer, Michael, Dolezalova, Pavla, Foeldvari, Ivan, Horneff, Gerd, Estmann, Anne, Pruunsild, Chris, Merino, Rosa, Penades, Inmaculada Calvo, Del Castillo, Pablo Mesa, Lahdenne, Pekka, Ioseliani, Maka, Trachana, Maria, Vougiouka, Olga, Harjacek, Miroslav, Orban, Ilonka, Constantin, Tamas, Shafaie, Nahid, Panaviene, Violeta Vladislava, Rygg, Marite, Smolewska, Elzbieta, Gomes, Jose Antonio Melo, Vojinovic, Jelena, Alexeeva, Ekaterina, Avcin, Tadej, Vargova, Veronika, Ayaz, Nuray Aktay, Ozgur Kasapcopur, Boyko, Yaryna, Ringold, Sarah, Rinaldi, Mariangela, Garrone, Marco, Ruperto, Nicolino, and Ravelli, Angelo
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juvenile idiopathic arthritis (JIA) and outcome measures ,Disease Activity - Published
- 2017
20. Development of New Juvenile Arthritis Disease Activity Score Cut-Offs for Oligoarthritis and RF-Negative Polyarthritis from a Large Multinational Cohort of Children with Juvenile Idiopathic Arthritis
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Immuno/reuma onderzoek 1 (Vastert), Consolaro, Alessandro, Van Dijkhuizen, Pieter, Espada, Graciela, Varbanova, Boriana, Oliveira-Knupp, Sheila, Miettunen, Paivi, Chedeville, Gaelle, Hofer, Michael, Dolezalova, Pavla, Foeldvari, Ivan, Horneff, Gerd, Estmann, Anne, Pruunsild, Chris, Merino, Rosa, Penades, Inmaculada Calvo, del Castillo, Pablo Mesa, Lahdenne, Pekka, Ioseliani, Maka, Trachana, Maria, Vougiouka, Olga, Harjacek, Miroslav, Orban, Ilonka, Constantin, Tamas, Shafaie, Nahid, Panaviene, Violeta Vladislava, Rygg, Marite, Smolewska, Elzbieta, Gomes, Jose Antonio Melo, Vojinovic, Jelena, Alexeeva, Ekaterina, Avcin, Tadej, Vargova, Veronika, Ayaz, Nuray Aktay, Kasapcopur, Ozgur, Boyko, Yaryna, Ringold, Sarah, Rinaldi, Mariangela, Garrone, Marco, Ruperto, Nicolino, Ravelli, Angelo, Immuno/reuma onderzoek 1 (Vastert), Consolaro, Alessandro, Van Dijkhuizen, Pieter, Espada, Graciela, Varbanova, Boriana, Oliveira-Knupp, Sheila, Miettunen, Paivi, Chedeville, Gaelle, Hofer, Michael, Dolezalova, Pavla, Foeldvari, Ivan, Horneff, Gerd, Estmann, Anne, Pruunsild, Chris, Merino, Rosa, Penades, Inmaculada Calvo, del Castillo, Pablo Mesa, Lahdenne, Pekka, Ioseliani, Maka, Trachana, Maria, Vougiouka, Olga, Harjacek, Miroslav, Orban, Ilonka, Constantin, Tamas, Shafaie, Nahid, Panaviene, Violeta Vladislava, Rygg, Marite, Smolewska, Elzbieta, Gomes, Jose Antonio Melo, Vojinovic, Jelena, Alexeeva, Ekaterina, Avcin, Tadej, Vargova, Veronika, Ayaz, Nuray Aktay, Kasapcopur, Ozgur, Boyko, Yaryna, Ringold, Sarah, Rinaldi, Mariangela, Garrone, Marco, Ruperto, Nicolino, and Ravelli, Angelo
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- 2017
21. Cardiovascular Risk of Nonsteroidal Anti-Inflammatory Drugs: An Under-Recognized Public Health Issue
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Varga, Zoltan, primary, Sabzwari, Syed rafay ali, additional, and Vargova, Veronika, additional
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- 2017
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22. Prednisone versus prednisone plus ciclosporin versus prednisone plus methotrexate in new-onset juvenile dermatomyositis: a randomised trial
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Infection & Immunity, Regenerative Medicine and Stem Cells, Child Health, Immuno/reuma patientenzorg, Ruperto, Nicolino, Pistorio, Angela, Oliveira, Sheila, Zulian, Francesco, Cuttica, Ruben, Ravelli, Angelo, Fischbach, Michel, Magnusson, Bo, Sterba, Gary, Avcin, Tadej, Brochard, Karine, Corona, Fabrizia, Dressler, Frank, Gerloni, Valeria, Apaz, Maria T, Bracaglia, Claudia, Cespedes-Cruz, Adriana, Cimaz, Rolando, Couillault, Gerard, Joos, Rik, Quartier, Pierre, Russo, Ricardo, Tardieu, Marc, Wulffraat, Nico, Bica, Blanca, Dolezalova, Pavla, Ferriani, Virginia, Flato, Berit, Bernard-Medina, Ana G, Herlin, Troels, Trachana, Maria, Meini, Antonella, Allain-Launay, Emma, Pilkington, Clarissa, Vargova, Veronika, Wouters, Carine, Angioloni, Simona, Martini, Alberto, Paediatric Rheumatology International Trials Organisation (PRINTO), Infection & Immunity, Regenerative Medicine and Stem Cells, Child Health, Immuno/reuma patientenzorg, Ruperto, Nicolino, Pistorio, Angela, Oliveira, Sheila, Zulian, Francesco, Cuttica, Ruben, Ravelli, Angelo, Fischbach, Michel, Magnusson, Bo, Sterba, Gary, Avcin, Tadej, Brochard, Karine, Corona, Fabrizia, Dressler, Frank, Gerloni, Valeria, Apaz, Maria T, Bracaglia, Claudia, Cespedes-Cruz, Adriana, Cimaz, Rolando, Couillault, Gerard, Joos, Rik, Quartier, Pierre, Russo, Ricardo, Tardieu, Marc, Wulffraat, Nico, Bica, Blanca, Dolezalova, Pavla, Ferriani, Virginia, Flato, Berit, Bernard-Medina, Ana G, Herlin, Troels, Trachana, Maria, Meini, Antonella, Allain-Launay, Emma, Pilkington, Clarissa, Vargova, Veronika, Wouters, Carine, Angioloni, Simona, Martini, Alberto, and Paediatric Rheumatology International Trials Organisation (PRINTO)
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- 2016
23. A52: The Impact of Adalimumab on Growth in Patients With Juvenile Idiopathic Arthritis
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Lovell, Daniel J., primary, Ruperto, Nicola, additional, Jarosova, Katerina, additional, Nemcova, Dana, additional, Vargova, Veronika, additional, Michels, Hartmut, additional, Chalom, Elizabeth, additional, Ilowite, Norman, additional, Wouters, Carine, additional, Brunner, Hermine, additional, Kupper, Hartmut, additional, Giannini, Edward, additional, and Martini, Alberto, additional
- Published
- 2014
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24. Additional file 4 of Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis: analysis by the Pharmachild Safety Adjudication Committee
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Giancane, Gabriella, Swart, Joost F., Castagnola, Elio, Groll, Andreas H., Horneff, Gerd, Hans-Iko Huppertz, Lovell, Daniel J., Wolfs, Tom, Herlin, Troels, Dolezalova, Pavla, Sanner, Helga, Susic, Gordana, Sztajnbok, Flavio, Maritsi, Despoina, Constantin, Tamas, Vargova, Veronika, Sawhney, Sujata, Marite Rygg, Oliveira, Sheila K., Cattalini, Marco, Bovis, Francesca, Bagnasco, Francesca, Pistorio, Angela, Martini, Alberto, Wulffraat, Nico, and Ruperto, Nicolino
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musculoskeletal diseases ,3. Good health - Abstract
Additional file 4 Table 2. Concomitant medications administered at the time of “confirmed OI”. Bio: biologic, mtx: methotrexate; ste: systemic steroids; sDMARDs: synthetic disease modifying antirheumatic drugs; *sDMARDs are intendend other than MTX.
25. Additional file 4 of Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis: analysis by the Pharmachild Safety Adjudication Committee
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Giancane, Gabriella, Swart, Joost F., Castagnola, Elio, Groll, Andreas H., Horneff, Gerd, Hans-Iko Huppertz, Lovell, Daniel J., Wolfs, Tom, Herlin, Troels, Dolezalova, Pavla, Sanner, Helga, Susic, Gordana, Sztajnbok, Flavio, Maritsi, Despoina, Constantin, Tamas, Vargova, Veronika, Sawhney, Sujata, Marite Rygg, Oliveira, Sheila K., Cattalini, Marco, Bovis, Francesca, Bagnasco, Francesca, Pistorio, Angela, Martini, Alberto, Wulffraat, Nico, and Ruperto, Nicolino
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musculoskeletal diseases ,3. Good health - Abstract
Additional file 4 Table 2. Concomitant medications administered at the time of “confirmed OI”. Bio: biologic, mtx: methotrexate; ste: systemic steroids; sDMARDs: synthetic disease modifying antirheumatic drugs; *sDMARDs are intendend other than MTX.
26. The Impact of Adalimumab On Growth in Patients with Juvenile Idiopathic Arthritis
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Lovell, D. J., Ruperto, Nicolino, Jarosova, Katerina, Dana Němcova, Vargova, Veronika, Michels, Hartmut, Chalom, Elizabeth, Ilowite, Norman, Wouters, Carine, Brunner, Hermine, Kracht, Karolyn, Kupper, Hartmut, Giannini, Edward, Martini, Alberto, and Mozaffarian, Neelufar
27. Additional file 3 of Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis: analysis by the Pharmachild Safety Adjudication Committee
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Giancane, Gabriella, Swart, Joost F., Castagnola, Elio, Groll, Andreas H., Horneff, Gerd, Hans-Iko Huppertz, Lovell, Daniel J., Wolfs, Tom, Herlin, Troels, Dolezalova, Pavla, Sanner, Helga, Susic, Gordana, Sztajnbok, Flavio, Maritsi, Despoina, Constantin, Tamas, Vargova, Veronika, Sawhney, Sujata, Marite Rygg, Oliveira, Sheila K., Cattalini, Marco, Bovis, Francesca, Bagnasco, Francesca, Pistorio, Angela, Martini, Alberto, Wulffraat, Nico, and Ruperto, Nicolino
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3. Good health - Abstract
Additional file 3 Table 1. Complete table with the frequency of the 682 infections adjudicated by the SAC. Infections were reported after evaluation of the cases available in Pharmachild compared to the pathogens/presentations in the provisional list approved by the Safety Adjudication Committee (SAC). Data are presented as per the MedDRA High Level Term (HLT) and Preferred Term (PT) sorted by frequencies in descending order (HLT and then PT). *For definition see Step 5.
28. The Addition of One or More Biologics to Methotrexate in Children with Juvenile Idiopathic Arthritis Increases the Incidence of Infections and Other Adverse Events
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Swart, Joost, Pistorio, Angela, Bovis, Francesca, Alexeeva, Ekaterina, Hofer, Michael, Nielsen, Susan, Anton, Jordi, ALESSANDRO CONSOLARO, Panaviene, Violeta Vladislava, Stanevicha, Valda, Trachana, Maria, Ailioaie, Constantin, Uettwiller, Florence, Benedetti, Fabrizio, Tsitsami, Elena, Flato, Berit, Dolezalova, Pavla, Constantin, Tamas, Herlin, Troels, Kamphuis, Sylvia, Sawhney, Sujata, Maritsi, Despoina, Vargova, Veronika, Villa, Luca, Pallotti, Chiara, Ravelli, Angelo, Martini, Alberto, Wulffraat, Nico, Ruperto, Nicolino, and PRINTO
29. Additional file 1 of Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis: analysis by the Pharmachild Safety Adjudication Committee
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Giancane, Gabriella, Swart, Joost F., Castagnola, Elio, Groll, Andreas H., Horneff, Gerd, Hans-Iko Huppertz, Lovell, Daniel J., Wolfs, Tom, Herlin, Troels, Dolezalova, Pavla, Sanner, Helga, Susic, Gordana, Sztajnbok, Flavio, Maritsi, Despoina, Constantin, Tamas, Vargova, Veronika, Sawhney, Sujata, Marite Rygg, Oliveira, Sheila K., Cattalini, Marco, Bovis, Francesca, Bagnasco, Francesca, Pistorio, Angela, Martini, Alberto, Wulffraat, Nico, and Ruperto, Nicolino
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3. Good health - Abstract
Additional file 1 figure. Flowchart of the process.
30. Additional file 2 of Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis: analysis by the Pharmachild Safety Adjudication Committee
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Giancane, Gabriella, Swart, Joost F., Castagnola, Elio, Groll, Andreas H., Horneff, Gerd, Hans-Iko Huppertz, Lovell, Daniel J., Wolfs, Tom, Herlin, Troels, Dolezalova, Pavla, Sanner, Helga, Susic, Gordana, Sztajnbok, Flavio, Maritsi, Despoina, Constantin, Tamas, Vargova, Veronika, Sawhney, Sujata, Marite Rygg, Oliveira, Sheila K., Cattalini, Marco, Bovis, Francesca, Bagnasco, Francesca, Pistorio, Angela, Martini, Alberto, Wulffraat, Nico, and Ruperto, Nicolino
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3. Good health - Abstract
Additional file 2 figure. Hierarchy of MedDra clinically-validated international medical terminology.
31. Additional file 1 of Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis: analysis by the Pharmachild Safety Adjudication Committee
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Giancane, Gabriella, Swart, Joost F., Castagnola, Elio, Groll, Andreas H., Horneff, Gerd, Hans-Iko Huppertz, Lovell, Daniel J., Wolfs, Tom, Herlin, Troels, Dolezalova, Pavla, Sanner, Helga, Susic, Gordana, Sztajnbok, Flavio, Maritsi, Despoina, Constantin, Tamas, Vargova, Veronika, Sawhney, Sujata, Marite Rygg, Oliveira, Sheila K., Cattalini, Marco, Bovis, Francesca, Bagnasco, Francesca, Pistorio, Angela, Martini, Alberto, Wulffraat, Nico, and Ruperto, Nicolino
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3. Good health - Abstract
Additional file 1 figure. Flowchart of the process.
32. Additional file 2 of Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis: analysis by the Pharmachild Safety Adjudication Committee
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Giancane, Gabriella, Swart, Joost F., Castagnola, Elio, Groll, Andreas H., Horneff, Gerd, Hans-Iko Huppertz, Lovell, Daniel J., Wolfs, Tom, Herlin, Troels, Dolezalova, Pavla, Sanner, Helga, Susic, Gordana, Sztajnbok, Flavio, Maritsi, Despoina, Constantin, Tamas, Vargova, Veronika, Sawhney, Sujata, Marite Rygg, Oliveira, Sheila K., Cattalini, Marco, Bovis, Francesca, Bagnasco, Francesca, Pistorio, Angela, Martini, Alberto, Wulffraat, Nico, and Ruperto, Nicolino
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3. Good health - Abstract
Additional file 2 figure. Hierarchy of MedDra clinically-validated international medical terminology.
33. Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis: analysis by the Pharmachild Safety Adjudication Committee
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Giancane G1, Swart JF2, Castagnola E3, Groll AH4, Horneff G5, 6, Huppertz HI7, Lovell DJ8, Wolfs T2, Herlin T9, Dolezalova P10, Sanner H11, Susic G13, Sztajnbok F14, Maritsi D15, Constantin T16, Vargova V17, Sawhney S18, Rygg M19, K Oliveira S21, Cattalini M22, Bovis F1, Bagnasco F1, Pistorio A23, Martini A24, Wulffraat N2, Ruperto N25, Paediatric Rheumatology International Trials Organisation (PRINTO). Cuttica R, Garay SM, Brunner J, Emminger W, Appenzeller S, Len C, Saad Magalhaes C, Telcharova-Mihaylovska A, Harjacek M, Jelusic M, Estmann A, Nielsen S, Herrera Mora C, Gervais E, Koné-Paut I, Quartier P, Foeldvari I, Horneff G, Lutz T, Minden K, Tzaribachev N, Trachana M, Tsitsami E, Vougiouka O, Orban I, Harel L, Hashkes P, Uziel Y, Cimaz R, Civino A, Consolini R, D'Angelo G, De Benedetti F, Filocamo G, Fueri E, Gallizzi R, Maggio MC, Magnolia MG, Miniaci A, Montin D, Olivieri A. N., Pastore S, Rigante D, Zulian F, Rumba-Rozenfelde I, Stanevicha V, Panaviene V, Rodriguez Lozano AL, Rubio-Perez N, Vega Cornejo G, Hoppenreijs E, Kamphuis S, Flato B, Nordal EB, Abdwani R, Miraval T, Paz Gastanaga ME, Smolewska E, Ailioaie C, Cochino AV, Laday M, Lazar C, Alexeeva E, Chasnyk V, Keltsev V, Suwairi WMS, Vijatov-Djuric G, Vojinovic J, Arkachaisri T, Koskova E, Avcin T, Ally M, Van Rensburg CJ, Louw I, Lopez JA, Boteanu AL, Calvo Penades I, De Inocencio J, Mesa-Del-Castillo P, Moreno E, Remesal A, Hofer M, Gok F, Ozen S, Ramanan A, Pallotti C, Villa L., Giancane, G1, Swart, Jf2, Castagnola, E3, Groll, Ah4, Horneff, G5, Huppertz, Hi7, Lovell, Dj8, Wolfs, T2, Herlin, T9, Dolezalova, P10, Sanner, H11, Susic, G13, Sztajnbok, F14, Maritsi, D15, Constantin, T16, Vargova, V17, Sawhney, S18, Rygg, M19, K Oliveira, S21, Cattalini, M22, Bovis, F1, Bagnasco, F1, Pistorio, A23, Martini, A24, Wulffraat, N2, Ruperto, N25, Paediatric Rheumatology International Trials Organisation (PRINTO)., Cuttica R, Garay, Sm, Brunner, J, Emminger, W, Appenzeller, S, Len, C, Saad Magalhaes, C, Telcharova-Mihaylovska, A, Harjacek, M, Jelusic, M, Estmann, A, Nielsen, S, Herrera Mora, C, Gervais, E, Koné-Paut, I, Quartier, P, Foeldvari, I, Horneff, G, Lutz, T, Minden, K, Tzaribachev, N, Trachana, M, Tsitsami, E, Vougiouka, O, Orban, I, Harel, L, Hashkes, P, Uziel, Y, Cimaz, R, Civino, A, Consolini, R, D'Angelo, G, De Benedetti, F, Filocamo, G, Fueri, E, Gallizzi, R, Maggio, Mc, Magnolia, Mg, Miniaci, A, Montin, D, Olivieri, A. N., Pastore, S, Rigante, D, Zulian, F, Rumba-Rozenfelde, I, Stanevicha, V, Panaviene, V, Rodriguez Lozano, Al, Rubio-Perez, N, Vega Cornejo, G, Hoppenreijs, E, Kamphuis, S, Flato, B, Nordal, Eb, Abdwani, R, Miraval, T, Paz Gastanaga, Me, Smolewska, E, Ailioaie, C, Cochino, Av, Laday, M, Lazar, C, Alexeeva, E, Chasnyk, V, Keltsev, V, Suwairi, Wm, Vijatov-Djuric, G, Vojinovic, J, Arkachaisri, T, Koskova, E, Avcin, T, Ally, M, Van Rensburg, Cj, Louw, I, Lopez, Ja, Boteanu, Al, Calvo Penades, I, De Inocencio, J, Mesa-Del-Castillo, P, Moreno, E, Remesal, A, Hofer, M, Gok, F, Ozen, S, Ramanan, A, Pallotti, C, Villa, L., Giancane, Gabriella, Swart, Joost F, Castagnola, Elio, Groll, Andreas H, Horneff, Gerd, Huppertz, Hans-Iko, Lovell, Daniel J, Wolfs, Tom, Herlin, Troel, Dolezalova, Pavla, Sanner, Helga, Susic, Gordana, Sztajnbok, Flavio, Maritsi, Despoina, Constantin, Tama, Vargova, Veronika, Sawhney, Sujata, Rygg, Marite, K Oliveira, Sheila, Cattalini, Marco, Bovis, Francesca, Bagnasco, Francesca, Pistorio, Angela, Martini, Alberto, Wulffraat, Nico, Ruperto, Nicolino, Cuttica, Ruben, Garay, Stella Mari, Brunner, Jurgen, Emminger, Wolfgang, Appenzeller, Simone, Len, Claudio, Saad Magalhaes, Claudia, Telcharova-Mihaylovska, Albena, Harjacek, Miroslav, Jelusic, Marija, Estmann, Anne, Nielsen, Susan, Herrera Mora, Cristina, Gervais, Elisabeth, Koné-Paut, Isabelle, Quartier, Pierre, Foeldvari, Ivan, Lutz, Thoma, Minden, Kirsten, Tzaribachev, Nikolay, Trachana, Maria, Tsitsami, Elena, Vougiouka, Olga, Orban, Ilonka, Harel, Liora, Hashkes, Philip, Uziel, Yosef, Cimaz, Rolando, Civino, Adele, Consolini, Rita, D'Angelo, Gianfranco, De Benedetti, Fabrizio, Filocamo, Giovanni, Fueri, Elena, Gallizzi, Romina, Maggio, Maria Cristina, Magnolia, Maria Greca, Miniaci, Angela, Montin, Davide, Olivieri, Alma Nunzia, Pastore, Serena, Rigante, Donato, Zulian, Francesco, Rumba-Rozenfelde, Ingrida, Stanevicha, Valda, Panaviene, Violeta, Rodriguez Lozano, Ana Luisa, Rubio-Perez, Nadina, Vega Cornejo, Gabriel, Hoppenreijs, Esther, Kamphuis, Sylvia, Flato, Berit, Nordal, Ellen Berit, Abdwani, Reem, Miraval, Tatiana, Paz Gastanaga, Maria Eliana, Smolewska, Elzbieta, Ailioaie, Constantin, Cochino, Alexis-Virgil, Laday, Matilda, Lazar, Calin, Alexeeva, Ekaterina, Chasnyk, Vyacheslav, Keltsev, Vladimir, Suwairi, Wafaa Mohammed Saad, Vijatov-Djuric, Gordana, Vojinovic, Jelena, Arkachaisri, Thaschawee, Koskova, Elena, Avcin, Tadej, Ally, Mahmood, Van Rensburg, Christa Janse, Louw, Ingrid, Lopez, Jordi Anton, Boteanu, Alina Lucica, Calvo Penades, Inmaculada, De Inocencio, Jaime, Mesa-Del-Castillo, Pablo, Moreno, Estefania, Remesal, Agustin, Hofer, Michael, Gok, Faysal, Ozen, Seza, Ramanan, Athimalaipet, Pallotti, Chiara, Villa, Luca, and Pediatrics
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Male ,lcsh:Diseases of the musculoskeletal system ,Biologic ,Paediatrics: 760 [VDP] ,Artritis infecciosa ,MedDRA ,Infants malalts ,Arthritis ,Severity of Illness Index ,Hospital patients ,Cohort Studies ,Pharmacovigilance ,0302 clinical medicine ,030212 general & internal medicine ,Registries ,Child ,Biologics ,Immunosuppressive therapy ,Infections ,Juvenile idiopathic arthritis ,Opportunistic ,biologics ,immunosuppressive therapy ,infections ,juvenile idiopathic arthritis ,opportunistic ,Barneleddgikt ,3. Good health ,Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA ,Antirheumatic Agents ,Child, Preschool ,Cohort ,Pediatric Infectious Disease ,Female ,Infection ,Research Article ,medicine.medical_specialty ,Tuberculosis ,juvenil idiopathic arthritis ,Opportunistic Infections ,Herpes Zoster ,03 medical and health sciences ,Immunocompromised Host ,Juvenile idiopathic arthriti ,Internal medicine ,medicine ,Humans ,book ,030203 arthritis & rheumatology ,Malalts hospitalitzats ,Immunosupressió ,business.industry ,Sick children ,medicine.disease ,Rheumatology ,Arthritis, Juvenile ,Infectious arthritis ,Pediatri: 760 [VDP] ,Orthopedic surgery ,Opportunistiske infeksjoner ,book.journal ,lcsh:RC925-935 ,business ,Infeccions oportunistes ,Immunosuppression - Abstract
Background: To derive a list of opportunistic infections (OI) through the analysis of the juvenile idiopathic arthritis (JIA) patients in the Pharmachild registry by an independent Safety Adjudication Committee (SAC). Methods: The SAC (3 pediatric rheumatologists and 2 pediatric infectious disease specialists) elaborated and approved by consensus a provisional list of OI for use in JIA. Through a 5 step-procedure, all the severe and serious infections, classified as per MedDRA dictionary and retrieved in the Pharmachild registry, were evaluated by the SAC by answering six questions and adjudicated with the agreement of 3/5 specialists. A final evidence-based list of OI resulted by matching the adjudicated infections with the provisional list of OI. Results: A total of 772 infectious events in 572 eligible patients, of which 335 serious/severe/very severe non-OI and 437 OI (any intensity/severity), according to the provisional list, were retrieved. Six hundred eighty-two of 772 (88.3%) were adjudicated as infections, of them 603/682 (88.4%) as common and 119/682 (17.4%) as OI by the SAC. Matching these 119 opportunistic events with the provisional list, 106 were confirmed by the SAC as OI, and among them infections by herpes viruses were the most frequent (68%), followed by tuberculosis (27.4%). The remaining events were divided in the groups of non-OI and possible/patient and/or pathogen-related OI. Conclusions: We found a significant number of OI in JIA patients on immunosuppressive therapy. The proposed list of OI, created by consensus and validated in the Pharmachild cohort, could facilitate comparison among future pharmacovigilance studies. © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
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- 2020
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34. Phenotypic variability and disparities in treatment and outcomes of childhood arthritis throughout the world: an observational cohort study
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Adriana Apostol, Matilda Laday, Michael Hofer, Amita Aggarwal, Pierre Quartier, Dirk Foell, Raju Khubchandani, Nikolay Tzaribachev, Patrizia Barone, Angela Pistorio, Ivan Foeldvari, Angela Miniaci, Pamela Weiss, Nicolino Ruperto, Violeta Panaviene, Claudia Saad Magalhães, Betül Sözeri, Gordana Vijatov-Djuric, Erkan Demirkaya, Carine Wouters, Calin Lazar, Rubén Burgos-Vargas, Tamás Constantin, Zoilo Morel Ayala, Carmen De Cunto, Elena Tsitsami, Marta Torcoletti, B Varbanova, Angelo Ravelli, Nahid Shafaie, Soad Hashad, Maria Greca Magnolia, José Melo-Gomes, Kirsten Minden, Ilonka Orbán, Flavio Sztajnbok, Maka Ioseliani, Ingrida Rumba-Rozenfelde, Silvia Magni Manzoni, Francesca Bovis, Berit Flatø, Stella Garay, Olga Arguedas, Maria Cristina Maggio, Yahya Aghighi, Sujata Sawhney, Francesco La Torre, Ruben Cuttica, Jaime de Inocencio, Clara Malagon, Alina Boteanu, Gerd Horneff, Silvana Martino, Sulaiman M. Al-Mayouf, Alberto Martini, Maria Trachana, Christiaan Scott, Rolando Cimaz, Nuray Aktay Ayaz, Maya-Feriel Aiche, Irina Nikishina, Valeria Gerloni, Sylvia Kamphuis, Olga Vougiouka, Dirk Holzinger, Reza Shiari, Sara Pieropan, Nico M Wulffraat, Inmaculada Calvo Penades, MM Katsicas, Pablo Mesa-del-Castillo, Lidia Rutkowska-Sak, Cristina Herrera, Jelena Vojinovic, Daniel J. Lovell, Erbil Unsal, Miroslav Harjacek, Yosef Uziel, Dimitrina Mihaylova, Gordana Susic, Susan Nielsen, Pekka Lahdenne, Soamarat Vilaiyuk, Rita Consolini, Ekaterina Alexeeva, Chris Pruunsild, Gaëlle Chédeville, Nicolae Iagaru, Ozgur Kasapcopur, Troels Herlin, Anne Estmann Christensen, Yaryna Boyko, Carolina Montobbio, Sarah Ringold, Johannes-Peter Haas, Gerd Ganser, Jordi Anton, Marite Rygg, Liisa Kröger, Reem Abdwani, Pavla Dolezalova, Paivi Miettunen, Rosa Anna Podda, Sheila Knupp Feitosa de Oliveira, Graciela Espada, Richard Vesely, Merja Malin, Liora Harel, Veronika Vargova, Mohammad Hasan Moradinejad, Neil A. Martin, Adele Civino, Tadej Avcin, Hans-Iko Huppertz, Ellen Nordal, Ximena Norambuena, Alessandra Alongi, Serena Pastore, Karaman Pagava, Maria Ekelund, Donato Rigante, Rotraud K. Saurenmann, Lillemor Berntson, Tomáš Dallos, Elżbieta Smolewska, Rik Joos, Andrea Militaru, Alessandro Consolaro, C. 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Male ,medicine.medical_specialty ,Childhood arthritis ,Cross-sectional study ,Population ,Global Health ,Pediatrics ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Epidemiology ,medicine ,Developmental and Educational Psychology ,Journal Article ,Humans ,Pediatrics, Perinatology and Child Health ,030212 general & internal medicine ,Healthcare Disparities ,Child ,education ,Disease burden ,Pain Measurement ,Retrospective Studies ,education.field_of_study ,Oligoarthritis ,business.industry ,Perinatology and Child Health ,Juvenile idiopathic arthritis ,medicine.disease ,JUVENILE IDIOPATHIC ARTHRITIS ,OF-RHEUMATOLOGY RECOMMENDATIONS ,DISEASE-ACTIVITY SCORE ,DEFINING CRITERIA ,CLASSIFICATION ,CHILDREN ,EPIDEMIOLOGY ,VALIDATION ,COUNTRIES ,VALIDITY ,Arthritis, Juvenile ,childhood arthritis,phenotypic variability,observational cohort study ,Cross-Sectional Studies ,Biological Variation, Population ,Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA ,Antirheumatic Agents ,Child, Preschool ,Quality of Life ,Female ,Polyarthritis ,Juvenile idiopatic arthritis, of-rheumatology recommentadions, disease-activity score, defining criteria, classification, children, epidemiology, validation, countries, validity ,business ,Demography ,Cohort study - Abstract
Made available in DSpace on 2019-10-05T16:54:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-04-01 IRCCS Istituto Giannina Gaslini Background To our knowledge, the characteristics and burden of childhood arthritis have never been studied on a worldwide basis. We aimed to investigate, with a cross-sectional study, the prevalence of disease categories, treatment methods, and disease status in patients from across different geographical areas and from countries with diverse wealth status. Methods In this multinational, cross-sectional, observational cohort study, we asked international paediatric rheumatologists from specialised centres to enrol children with a diagnosis of juvenile idiopathic arthritis, according to International League of Associations for Rheumatology criteria, who were seen consecutively for a period of 6 months. Each patient underwent retrospective and cross-sectional assessments, including measures of disease activity and damage and questionnaires on the wellbeing and quality of life of the children. We qualitatively compared the collected data across eight geographical areas, and we explored an association between disease activity and damage and a country's gross domestic product (GDP) with a multiple logistic regression analysis. Findings Between April 4, 2011, and Nov 21, 2016, 9081 patients were enrolled at 130 centres in 49 countries, grouped into eight geographical areas. Systemic arthritis (125 [33.0%] of 379 patients) and enthesitis-related arthritis (113 [29.8%] of 379) were more common in southeast Asia, whereas oligoarthritis was more prevalent in southern Europe (1360 [56.7%] of 2400) and rheumatoid factor-negative polyarthritis was more frequent in North America (165 [31.5%] of 523) than in the other areas. Prevalence of uveitis was highest in northern Europe (161 [19.1%] of 845 patients) and southern Europe (450 [18.8%] of 2400) and lowest in Latin America (54 [6.4%] of 849), Africa and Middle East (71 [5.9%] of 1209), and southeast Asia (19 [5.0%] of 379). Median age at disease onset was lower in southern Europe (3.5 years, IQR 1.9-7.3) than in other regions. Biological, disease-modifying antirheumatic drugs were prescribed more frequently in northern Europe and North America than in other geographical settings. Patients living in countries with lower GDP had greater disease activity and damage than those living in wealthier countries. Damage was associated with referral delay. Interpretation Our study documents a variability in prevalence of disease phenotypes and disparities in therapeutic choices and outcomes across geographical areas and wealth status of countries. The greater disease burden in lowerresource settings highlights the need for public health efforts aimed at improving equity in access to effective treatments and care for juvenile idiopathic arthritis. Copyright (C) 2019 Elsevier Ltd. All rights reserved. Univ Genoa, Ist Giannina Gaslini, IRCCS, Clin Paediat & Rheumatol, Genoa, Italy Univ Genoa, Ist Giannina Gaslini, IRCCS, Epidemiol & Biostat Serv, Genoa, Italy Univ Genoa, Ist Giannina Gaslini, IRCCS, Sci Directory, Genoa, Italy Univ Genoa, PRINTO, IRCCS, Ist Giannina Gaslini, Genoa, Italy Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet & Maternal, Genoa, Italy Wilhelmina Childrens Hosp, Dept Pediat Immunol & Rheumatol, Utrecht, Netherlands Sanjay Gandhi Postgrad Inst Med Sci, Lucknow, Uttar Pradesh, India Univ Hosp 12 Octubre, Dept Pediat Rheumatol, Madrid, Spain Alfaisal Univ, Dept Pediat Rheumatol, King Faisal Specialist Hosp, Riyadh, Saudi Arabia Alfaisal Univ, Res Ctr, Riyadh, Saudi Arabia Western Univ Childrens Hosp, Hlth Sci Ctr, London, ON, Canada Oslo Univ Hosp, Dept Rheumatol, Oslo, Norway Oslo Univ Hosp, Med Fac, Oslo, Norway Univ Oslo, Oslo, Norway Oslo Univ Hosp, Norwegian Natl Advisory Unit Rheumat Dis Children, Oslo, Norway Univ Hosp Munster, Dept Pediat Rheumatol & Immunol, Munster, Germany Hosp Sor Maria Ludovica, Rheumatol Serv, La Plata, Buenos Aires, Argentina Bucharest Emergency Hosp, Cluj Napoca, Romania Childrens Emergency Hosp, Cluj Napoca, Romania Cincinnati Childrens Hosp Med Ctr, Div Rheumatol, Cincinnati, OH 45229 USA Alberta Childrens Prov Gen Hosp, Div Pediat Rheumatol, Dept Pediat, Calgary, AB, Canada Sofiamed, Pediat Dept, Sofia, Bulgaria Rigshosp, Juliane Marie Ctr, Paediat Rheumatol Unit, Copenhagen, Denmark Natl Inst Rheumatism & Physiotherapy, Clin Immunol Adult & Paediat Rheumatol Dept, Budapest, Hungary Univ Latvia, Pediat Dept, Riga, Latvia Univ Latvia, Univ Childrens Hosp, Riga, Latvia Univ Estadual Paulista, Botucatu Fac Med, Botucatu, SP, Brazil Shariati Hosp, Rheumatol Res Ctr, Dept Pediat & Rheumatol, Tehran, Iran Inst Rheumatol Belgrade, Div Pediat Rheumatol, Belgrade, Serbia Thessaloniki Univ, Dept Pediat 1, Hippokrat Gen Hosp, Sch Med, Thessaloniki, Greece Univ Estadual Paulista, Botucatu Fac Med, Botucatu, SP, Brazil
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