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8. Wire-Free Targeted Axillary Dissection: A Pooled Analysis of 1300+ Cases Post-Neoadjuvant Systemic Therapy in Node-Positive Early Breast Cancer.

Author

Varghese, Jajini, Patani, Neill, Wazir, Umar, Novintan, Shonnelly, Michell, Michael J., Malhotra, Anmol, Mokbel, Kinan, and Mokbel, Kefah

Subjects
*SENTINEL lymph node biopsy, *PATIENT safety, *BREAST tumors, *AXILLARY lymph node dissection, *PATHOLOGIC complete response, *CHI-squared test, *DESCRIPTIVE statistics, *CANCER patients, *SYSTEMATIC reviews, *MEDLINE, *COMBINED modality therapy, *QUALITY of life, *ONLINE information services, *CONFIDENCE intervals, *DATA analysis software, *DISEASE incidence, *OVERALL survival
Abstract

Simple Summary: Preoperative chemotherapy significantly improves response rates in early breast cancer, challenging the traditional approach of invasive axillary surgery in patients presenting with node-positive disease. Wire-free localisation markers can successfully mark lymph nodes at diagnosis. Our findings demonstrate that these markers are successfully utilised, localised, and retrieved intraoperatively. Incorporating preoperative lymph node marking into the current biopsy procedure allows for more accurate staging of the axilla whilst reducing the need for invasive axillary surgery. These findings underscore the importance of incorporating both types of biopsies in axillary staging following preoperative chemotherapy for initially node-positive patients. Recent advances in neoadjuvant systemic therapy (NST) have significantly improved pathologic complete response rates in early breast cancer, challenging the role of axillary lymph node dissection in nose-positive patients. Targeted axillary dissection (TAD) integrates marked lymph node biopsy (MLNB) and tracer-guided sentinel lymph node biopsy (SLNB). The introduction of new wire-free localisation markers (LMs) has streamlined TAD and increased its adoption. The primary endpoints include the successful localisation and retrieval rates of LMs. The secondary endpoints include the pathological complete response (pCR), SLNB, and MLNB concordance, as well as false-negative rates. Seventeen studies encompassing 1358 TAD procedures in 1355 met the inclusion criteria. The localisation and retrieval rate of LMs were 97% and 99%. A concordance rate of 67% (95% CI: 64–70) between SLNB and MLNB was demonstrated. Notably, 49 days (range: 0–272) was the average LM deployment time to surgery. pCR was observed in 46% (95% CI: 43–49) of cases, with no significant procedure-related complications. Omitting MLNB or SLNB would have under-staged the axilla in 15.2% or 5.4% (p = 0.0001) of cases, respectively. MLNB inclusion in axillary staging post-NST for initially node-positive patients is crucial. The radiation-free Savi Scout, with its minimal MRI artefacts, is the preferred technology for TAD. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Supplementary Table 6 from Common Breast Cancer Susceptibility Variants in LSP1 and RAD51L1 Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk

Author

Vachon, Celine M., primary, Scott, Christopher G., primary, Fasching, Peter A., primary, Hall, Per, primary, Tamimi, Rulla M., primary, Li, Jingmei, primary, Stone, Jennifer, primary, Apicella, Carmel, primary, Odefrey, Fabrice, primary, Gierach, Gretchen L., primary, Jud, Sebastian M., primary, Heusinger, Katharina, primary, Beckmann, Matthias W., primary, Pollan, Marina, primary, Fernández-Navarro, Pablo, primary, Gonzalez-Neira, Anna, primary, Benitez, Javier, primary, van Gils, Carla H., primary, Lokate, Mariëtte, primary, Onland-Moret, N. Charlotte, primary, Peeters, Petra H.M., primary, Brown, Judith, primary, Leyland, Jean, primary, Varghese, Jajini S., primary, Easton, Douglas F., primary, Thompson, Deborah J., primary, Luben, Robert N., primary, Warren, Ruth M.L., primary, Wareham, Nicholas J., primary, Loos, Ruth J.F., primary, Khaw, Kay-Tee, primary, Ursin, Giske, primary, Lee, Eunjung, primary, Gayther, Simon A., primary, Ramus, Susan J., primary, Eeles, Rosalind A., primary, Leach, Martin O., primary, Kwan-Lim, Gek, primary, Couch, Fergus J., primary, Giles, Graham G., primary, Baglietto, Laura, primary, Krishnan, Kavitha, primary, Southey, Melissa C., primary, Le Marchand, Loic, primary, Kolonel, Laurence N., primary, Woolcott, Christy, primary, Maskarinec, Gertraud, primary, Haiman, Christopher A., primary, Walker, Kate, primary, Johnson, Nichola, primary, McCormack, Valeria A., primary, Biong, Margarethe, primary, Alnaes, Grethe I.G., primary, Gram, Inger Torhild, primary, Kristensen, Vessela N., primary, Børresen-Dale, Anne-Lise, primary, Lindström, Sara, primary, Hankinson, Susan E., primary, Hunter, David J., primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Boyd, Norman F., primary, Figuero, Jonine D., primary, Lissowska, Jolanta, primary, Wesolowska, Ewa, primary, Peplonska, Beata, primary, Bukowska, Agnieszka, primary, Reszka, Edyta, primary, Liu, JianJun, primary, Eriksson, Louise, primary, Czene, Kamila, primary, Audley, Tina, primary, Wu, Anna H., primary, Pankratz, V. Shane, primary, Hopper, John L., primary, and dos-Santos-Silva, Isabel, primary

Published
2023
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14. Supplementary Tables 1 - 4 from Common Breast Cancer Susceptibility Variants in LSP1 and RAD51L1 Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk

Author

Vachon, Celine M., primary, Scott, Christopher G., primary, Fasching, Peter A., primary, Hall, Per, primary, Tamimi, Rulla M., primary, Li, Jingmei, primary, Stone, Jennifer, primary, Apicella, Carmel, primary, Odefrey, Fabrice, primary, Gierach, Gretchen L., primary, Jud, Sebastian M., primary, Heusinger, Katharina, primary, Beckmann, Matthias W., primary, Pollan, Marina, primary, Fernández-Navarro, Pablo, primary, Gonzalez-Neira, Anna, primary, Benitez, Javier, primary, van Gils, Carla H., primary, Lokate, Mariëtte, primary, Onland-Moret, N. Charlotte, primary, Peeters, Petra H.M., primary, Brown, Judith, primary, Leyland, Jean, primary, Varghese, Jajini S., primary, Easton, Douglas F., primary, Thompson, Deborah J., primary, Luben, Robert N., primary, Warren, Ruth M.L., primary, Wareham, Nicholas J., primary, Loos, Ruth J.F., primary, Khaw, Kay-Tee, primary, Ursin, Giske, primary, Lee, Eunjung, primary, Gayther, Simon A., primary, Ramus, Susan J., primary, Eeles, Rosalind A., primary, Leach, Martin O., primary, Kwan-Lim, Gek, primary, Couch, Fergus J., primary, Giles, Graham G., primary, Baglietto, Laura, primary, Krishnan, Kavitha, primary, Southey, Melissa C., primary, Le Marchand, Loic, primary, Kolonel, Laurence N., primary, Woolcott, Christy, primary, Maskarinec, Gertraud, primary, Haiman, Christopher A., primary, Walker, Kate, primary, Johnson, Nichola, primary, McCormack, Valeria A., primary, Biong, Margarethe, primary, Alnaes, Grethe I.G., primary, Gram, Inger Torhild, primary, Kristensen, Vessela N., primary, Børresen-Dale, Anne-Lise, primary, Lindström, Sara, primary, Hankinson, Susan E., primary, Hunter, David J., primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Boyd, Norman F., primary, Figuero, Jonine D., primary, Lissowska, Jolanta, primary, Wesolowska, Ewa, primary, Peplonska, Beata, primary, Bukowska, Agnieszka, primary, Reszka, Edyta, primary, Liu, JianJun, primary, Eriksson, Louise, primary, Czene, Kamila, primary, Audley, Tina, primary, Wu, Anna H., primary, Pankratz, V. Shane, primary, Hopper, John L., primary, and dos-Santos-Silva, Isabel, primary

Published
2023
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15. Supplementary Table 5 from Common Breast Cancer Susceptibility Variants in LSP1 and RAD51L1 Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk

Author

Vachon, Celine M., primary, Scott, Christopher G., primary, Fasching, Peter A., primary, Hall, Per, primary, Tamimi, Rulla M., primary, Li, Jingmei, primary, Stone, Jennifer, primary, Apicella, Carmel, primary, Odefrey, Fabrice, primary, Gierach, Gretchen L., primary, Jud, Sebastian M., primary, Heusinger, Katharina, primary, Beckmann, Matthias W., primary, Pollan, Marina, primary, Fernández-Navarro, Pablo, primary, Gonzalez-Neira, Anna, primary, Benitez, Javier, primary, van Gils, Carla H., primary, Lokate, Mariëtte, primary, Onland-Moret, N. Charlotte, primary, Peeters, Petra H.M., primary, Brown, Judith, primary, Leyland, Jean, primary, Varghese, Jajini S., primary, Easton, Douglas F., primary, Thompson, Deborah J., primary, Luben, Robert N., primary, Warren, Ruth M.L., primary, Wareham, Nicholas J., primary, Loos, Ruth J.F., primary, Khaw, Kay-Tee, primary, Ursin, Giske, primary, Lee, Eunjung, primary, Gayther, Simon A., primary, Ramus, Susan J., primary, Eeles, Rosalind A., primary, Leach, Martin O., primary, Kwan-Lim, Gek, primary, Couch, Fergus J., primary, Giles, Graham G., primary, Baglietto, Laura, primary, Krishnan, Kavitha, primary, Southey, Melissa C., primary, Le Marchand, Loic, primary, Kolonel, Laurence N., primary, Woolcott, Christy, primary, Maskarinec, Gertraud, primary, Haiman, Christopher A., primary, Walker, Kate, primary, Johnson, Nichola, primary, McCormack, Valeria A., primary, Biong, Margarethe, primary, Alnaes, Grethe I.G., primary, Gram, Inger Torhild, primary, Kristensen, Vessela N., primary, Børresen-Dale, Anne-Lise, primary, Lindström, Sara, primary, Hankinson, Susan E., primary, Hunter, David J., primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Boyd, Norman F., primary, Figuero, Jonine D., primary, Lissowska, Jolanta, primary, Wesolowska, Ewa, primary, Peplonska, Beata, primary, Bukowska, Agnieszka, primary, Reszka, Edyta, primary, Liu, JianJun, primary, Eriksson, Louise, primary, Czene, Kamila, primary, Audley, Tina, primary, Wu, Anna H., primary, Pankratz, V. Shane, primary, Hopper, John L., primary, and dos-Santos-Silva, Isabel, primary

Published
2023
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17. Data from Mammographic Breast Density and Breast Cancer: Evidence of a Shared Genetic Basis

Author

Varghese, Jajini S., primary, Thompson, Deborah J., primary, Michailidou, Kyriaki, primary, Lindström, Sara, primary, Turnbull, Clare, primary, Brown, Judith, primary, Leyland, Jean, primary, Warren, Ruth M.L., primary, Luben, Robert N., primary, Loos, Ruth J., primary, Wareham, Nicholas J., primary, Rommens, Johanna, primary, Paterson, Andrew D., primary, Martin, Lisa J., primary, Vachon, Celine M., primary, Scott, Christopher G., primary, Atkinson, Elizabeth J., primary, Couch, Fergus J., primary, Apicella, Carmel, primary, Southey, Melissa C., primary, Stone, Jennifer, primary, Li, Jingmei, primary, Eriksson, Louise, primary, Czene, Kamila, primary, Boyd, Norman F., primary, Hall, Per, primary, Hopper, John L., primary, Tamimi, Rulla M., primary, Rahman, Nazneen, primary, and Easton, Douglas F., primary

Published
2023
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18. Supplementary Figure 1 from Mammographic Breast Density and Breast Cancer: Evidence of a Shared Genetic Basis

Author

Varghese, Jajini S., primary, Thompson, Deborah J., primary, Michailidou, Kyriaki, primary, Lindström, Sara, primary, Turnbull, Clare, primary, Brown, Judith, primary, Leyland, Jean, primary, Warren, Ruth M.L., primary, Luben, Robert N., primary, Loos, Ruth J., primary, Wareham, Nicholas J., primary, Rommens, Johanna, primary, Paterson, Andrew D., primary, Martin, Lisa J., primary, Vachon, Celine M., primary, Scott, Christopher G., primary, Atkinson, Elizabeth J., primary, Couch, Fergus J., primary, Apicella, Carmel, primary, Southey, Melissa C., primary, Stone, Jennifer, primary, Li, Jingmei, primary, Eriksson, Louise, primary, Czene, Kamila, primary, Boyd, Norman F., primary, Hall, Per, primary, Hopper, John L., primary, Tamimi, Rulla M., primary, Rahman, Nazneen, primary, and Easton, Douglas F., primary

Published
2023
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23. P102. Reporting and management of close/involved anterior margins after skin/nipple-sparing mastectomy: Multi-centre experience of national oncoplastic fellows in England

Author

Rizki, Hirah, primary, Quinn, Edel, additional, Arthur, Laura, additional, Rajan, SreeKumar, additional, Shah, Reena, additional, Goburdhun, Rachna, additional, Tan, Qing, additional, Layton, Abbie, additional, Covington, April, additional, Varghese, Jajini, additional, St John, Edward, additional, Leff, Daniel, additional, and Patani, Neill, additional

Published
2021
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27. Identification of a novel percent mammographic density locus at 12q24

Author

Stevens, Kristen N., Lindstrom, Sara, Scott, Christopher G., Thompson, Deborah, Sellers, Thomas A., Wang, Xianshu, Wang, Alice, Atkinson, Elizabeth, Rider, David N., Eckel-Passow, Jeanette E., Varghese, Jajini S., Audley, Tina, Brown, Judith, Leyland, Jean, Luben, Robert N., Warren, Ruth M.L., Loos, Ruth J.F., Wareham, Nicholas J., Li, Jingmei, Hall, Per, Liu, Jianjun, Eriksson, Louise, Czene, Kamila, Olson, Janet E., Shane Pankratz, V., Fredericksen, Zachary, Diasio, Robert B., Lee, Adam M., Heit, John A., deAndrade, Mariza, Goode, Ellen L., Vierkant, Robert A., Cunningham, Julie M., Armasu, Sebastian M., Weinshilboum, Richard, Fridley, Brooke L., Batzler, Anthony, Ingle, James N., Boyd, Norman F., Paterson, Andrew D., Rommens, Johanna, Martin, Lisa J., Hopper, John L., Southey, Melissa C., Stone, Jennifer, Apicella, Carmel, Kraft, Peter, Hankinson, Susan E., Hazra, Aditi, Hunter, David J., Easton, Douglas F., Couch, Fergus J., Tamimi, Rulla M., and Vachon, Celine M.

Published
2012
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36. Oro-facial fibrosis in systemic sclerosis: a reconstructive journey.

Author

Kyung Jeon, Faith Hyun, Griffin, Michelle, Varghese, Jajini, and Michael Butler, Peter Edward

Abstract

Oro-facial fibrosis presents a significant disease burden in patients with systemic sclerosis, but there remains no established treatment modality. Autologous fat grafting is a minimally invasive surgical procedure that is now increasingly recognised for its regenerative capacity, propagating an expansion of heterogeneous indications beyond volume restoration, including fibrotic diseases such as systemic sclerosis. We present a 42-year-old woman with oro-facial involvement of systemic sclerosis leading to severe limitation in mouth opening and closure, with marked retraction of the lower lip and gingival display. We describe the reconstructive journey over a 12-year period, where the antifibrotic effect of autologous fat grafting served as the basis on which a series of surgical procedures were performed to achieve functional and aesthetic improvement. Autologous fat grafting provides a novel treatment modality for orofacial skin fibrosis, previously considered a non-treatable disease manifestation of systemic sclerosis. [ABSTRACT FROM AUTHOR]

Published
2020
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37. Fat Hypertrophy as a Complication of Fat Transfer for Hemifacial Atrophy.

Author

Jeon, Faith H K, Varghese, Jajini, Griffin, Michelle, Mosahebi, Afshin, Butler, Peter E, Withey, Simon, and Henderson, Hugo

Abstract

Fat hypertrophy is a less commonly known complication of autologous fat transfer. We present a 32-year-old female with left hemifacial atrophy associated with systemic sclerosis, who was treated with 7 fat transfer procedures to correct the facial asymmetry. A total of 236.5 mL of fat was injected to the hemiface over a 4-year period to achieve good symmetry. A progressively enlarging, painless, soft mass over the left parotid region was noted at 3 months after the final fat transfer procedure. Magnetic resonance imaging showed a markedly enlarged bulk of subcutaneous fat over the left cheek with no evidence of necrosis, edema, or pathologic enhancement. Concurrent weight gain was noted secondary to additional nutritional input. The patient's aesthetic, symptomatic, and functional concerns led to the subsequent removal of 115 mL fat by liposuction.Level Of Evidence:5: [ABSTRACT FROM AUTHOR]

Published
2020
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44. Common Breast Cancer Susceptibility Variants in LSP1 and RAD51L1 Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk

Author

Vachon, Celine M., primary, Scott, Christopher G., additional, Fasching, Peter A., additional, Hall, Per, additional, Tamimi, Rulla M., additional, Li, Jingmei, additional, Stone, Jennifer, additional, Apicella, Carmel, additional, Odefrey, Fabrice, additional, Gierach, Gretchen L., additional, Jud, Sebastian M., additional, Heusinger, Katharina, additional, Beckmann, Matthias W., additional, Pollan, Marina, additional, Fernández-Navarro, Pablo, additional, Gonzalez-Neira, Anna, additional, Benitez, Javier, additional, van Gils, Carla H., additional, Lokate, Mariëtte, additional, Onland-Moret, N. Charlotte, additional, Peeters, Petra H.M., additional, Brown, Judith, additional, Leyland, Jean, additional, Varghese, Jajini S., additional, Easton, Douglas F., additional, Thompson, Deborah J., additional, Luben, Robert N., additional, Warren, Ruth M.L., additional, Wareham, Nicholas J., additional, Loos, Ruth J.F., additional, Khaw, Kay-Tee, additional, Ursin, Giske, additional, Lee, Eunjung, additional, Gayther, Simon A., additional, Ramus, Susan J., additional, Eeles, Rosalind A., additional, Leach, Martin O., additional, Kwan-Lim, Gek, additional, Couch, Fergus J., additional, Giles, Graham G., additional, Baglietto, Laura, additional, Krishnan, Kavitha, additional, Southey, Melissa C., additional, Le Marchand, Loic, additional, Kolonel, Laurence N., additional, Woolcott, Christy, additional, Maskarinec, Gertraud, additional, Haiman, Christopher A., additional, Walker, Kate, additional, Johnson, Nichola, additional, McCormack, Valeria A., additional, Biong, Margarethe, additional, Alnaes, Grethe I.G., additional, Gram, Inger Torhild, additional, Kristensen, Vessela N., additional, Børresen-Dale, Anne-Lise, additional, Lindström, Sara, additional, Hankinson, Susan E., additional, Hunter, David J., additional, Andrulis, Irene L., additional, Knight, Julia A., additional, Boyd, Norman F., additional, Figuero, Jonine D., additional, Lissowska, Jolanta, additional, Wesolowska, Ewa, additional, Peplonska, Beata, additional, Bukowska, Agnieszka, additional, Reszka, Edyta, additional, Liu, JianJun, additional, Eriksson, Louise, additional, Czene, Kamila, additional, Audley, Tina, additional, Wu, Anna H., additional, Pankratz, V. Shane, additional, Hopper, John L., additional, and dos-Santos-Silva, Isabel, additional

Published
2012
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45. Mammographic Breast Density and Breast Cancer: Evidence of a Shared Genetic Basis

Author

Varghese, Jajini S., primary, Thompson, Deborah J., additional, Michailidou, Kyriaki, additional, Lindström, Sara, additional, Turnbull, Clare, additional, Brown, Judith, additional, Leyland, Jean, additional, Warren, Ruth M.L., additional, Luben, Robert N., additional, Loos, Ruth J., additional, Wareham, Nicholas J., additional, Rommens, Johanna, additional, Paterson, Andrew D., additional, Martin, Lisa J., additional, Vachon, Celine M., additional, Scott, Christopher G., additional, Atkinson, Elizabeth J., additional, Couch, Fergus J., additional, Apicella, Carmel, additional, Southey, Melissa C., additional, Stone, Jennifer, additional, Li, Jingmei, additional, Eriksson, Louise, additional, Czene, Kamila, additional, Boyd, Norman F., additional, Hall, Per, additional, Hopper, John L., additional, Tamimi, Rulla M., additional, Rahman, Nazneen, additional, and Easton, Douglas F., additional

Published
2012
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48. Common variants in ZNF365 are associated with both mammographic density and breast cancer risk

Author

Lindström, Sara, primary, Vachon, Celine M, additional, Li, Jingmei, additional, Varghese, Jajini, additional, Thompson, Deborah, additional, Warren, Ruth, additional, Brown, Judith, additional, Leyland, Jean, additional, Audley, Tina, additional, Wareham, Nicholas J, additional, Loos, Ruth J F, additional, Paterson, Andrew D, additional, Rommens, Johanna, additional, Waggott, Darryl, additional, Martin, Lisa J, additional, Scott, Christopher G, additional, Pankratz, V Shane, additional, Hankinson, Susan E, additional, Hazra, Aditi, additional, Hunter, David J, additional, Hopper, John L, additional, Southey, Melissa C, additional, Chanock, Stephen J, additional, Silva, Isabel dos Santos, additional, Liu, JianJun, additional, Eriksson, Louise, additional, Couch, Fergus J, additional, Stone, Jennifer, additional, Apicella, Carmel, additional, Czene, Kamila, additional, Kraft, Peter, additional, Hall, Per, additional, Easton, Douglas F, additional, Boyd, Norman F, additional, and Tamimi, Rulla M, additional

Published
2011
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