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963 results on '"Varela, R"'

4. TRL analysis of IFMIF-DONES

Author

Brañas, B., Maestre, J., Bernardi, D., Ibarra, A., Arbeiter, F., Arena, P., Arranz, F., Becerril, S., Cappelli, M., Chel, S., Castellanos, J., Favuzza, P., Jiménez-Rey, D., Krolas, W., Martin-Fuertes, F., Micciché, G., Nitti, F.S., Podadera, I., Qiu, Y., Regidor, D., Renard, B., Tadic, T., Varela, R., and Weber, M.

Published
2024
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6. Computational approaches to Explainable Artificial Intelligence: Advances in theory, applications and trends

Author

Górriz, J.M., Álvarez-Illán, I., Álvarez-Marquina, A., Arco, J.E., Atzmueller, M., Ballarini, F., Barakova, E., Bologna, G., Bonomini, P., Castellanos-Dominguez, G., Castillo-Barnes, D., Cho, S.B., Contreras, R., Cuadra, J.M., Domínguez, E., Domínguez-Mateos, F., Duro, R.J., Elizondo, D., Fernández-Caballero, A., Fernandez-Jover, E., Formoso, M.A., Gallego-Molina, N.J., Gamazo, J., González, J. García, Garcia-Rodriguez, J., Garre, C., Garrigós, J., Gómez-Rodellar, A., Gómez-Vilda, P., Graña, M., Guerrero-Rodriguez, B., Hendrikse, S.C.F., Jimenez-Mesa, C., Jodra-Chuan, M., Julian, V., Kotz, G., Kutt, K., Leming, M., de Lope, J., Macas, B., Marrero-Aguiar, V., Martinez, J.J., Martinez-Murcia, F.J., Martínez-Tomás, R., Mekyska, J., Nalepa, G.J., Novais, P., Orellana, D., Ortiz, A., Palacios-Alonso, D., Palma, J., Pereira, A., Pinacho-Davidson, P., Pinninghoff, M.A., Ponticorvo, M., Psarrou, A., Ramírez, J., Rincón, M., Rodellar-Biarge, V., Rodríguez-Rodríguez, I., Roelofsma, P.H.M.P., Santos, J., Salas-Gonzalez, D., Salcedo-Lagos, P., Segovia, F., Shoeibi, A., Silva, M., Simic, D., Suckling, J., Treur, J., Tsanas, A., Varela, R., Wang, S.H., Wang, W., Zhang, Y.D., Zhu, H., Zhu, Z., and Ferrández-Vicente, J.M.

Published
2023
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10. Detecting mass sediment transport and movement tainted by decades of mining activities in river Quito, Western Colombia

Author

Marrugo-Negrete, José, Rodriguez-Espinosa, P.F., Godwyn-Paulson, P., Paternina-Uribe, Roberth J., Ibarguen Amud, Mareley Y., Rosso-Pinto, Mauricio, Enamorado-Montes, German, Urango-Cardenas, Ivan, Gutierrez-Mosquera, Harry, Salas-Moreno, Manuel Haminton, Salazar-Camacho, Carlos, Córdoba-Tovar, Leonomir, Ospino Contreras, Juan Camilo, Bolivar, Wilfredo Marimon, Arbelaez Salazar, Julian Dario, Valdes, Saul Milan, Varela, R. Dominguez, and Jonathan, M.P.

Published
2023
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12. Socially inclusive valorization of gold mill tailings from the small-scale gold mining sector.

Author

Balanay, R. M., Varela, R. P., Balbin, A. L., and Lavapiez, M. A.

Subjects
LEAD, HAZARDOUS substances, MINE waste, WASTE recycling, TAILINGS dams, GOLD mining
Abstract

BACKGROUND AND OBJECTIVES: Gold mining wastes have long been a significant concern in Agusan del Sur, a gold mining district in the Philippines. The region is vulnerable to climate change effects such as typhoons and flooding, which may lead to contaminated runoff or overflow that could potentially harm the local agriculture and adjacent natural ecosystems. This study aims to analyze the properties of the gold mill tailings, investigate their potential for reutilization, and identify areas that need improvement in order to promote an inclusive approach towards the valorization of mine waste. METHODS: The samples were collected randomly from a small- scale gold mill tailings storage facility. The samples underwent analysis for elemental and oxide composition, particle dimensions, potential of hydrogen, lead, mercury, free cyanide and hexavalent chromium. A gap analysis was utilized to pinpoint the methods for enhancing a socially inclusive reuse strategy for the mill tailings. FINDINGS: The characterization of the tailings reveal that some heavy metals like zinc, titanium, copper, barium, and manganese, and hazardous substances like arsenic, mercury, and lead are present. Elevated levels of mercury, lead, and free cyanide were detected in the wastewater, with concentrations of 0.029 milligram per liter, 0.40 milligram per liter, and 1.9 milligram per liter, respectively, surpassing the allowable thresholds. There is a high risk of contaminating the neighboring ecosystem during flooding events and waste overflow. The tailings also contain fine particles of about 75 percent fine sand and 25 percent clay. Adequate maintenance of tailings storage facilities, community awareness of waste-related risks and hazards, legal frameworks and financial backing to encourage waste utilization, local community empowerment, and adherence to occupational health and safety guidelines in waste management are essential strategies to bridge existing disparities and foster a socially inclusive approach to mine waste valorization. CONCLUSION: The gold mill tailings contain hazardous substances and fine dust, potentially damaging the nearby ecosystem and community. It is essential to prioritize the maintenance of a well-managed tailings storage facility in order to avoid contamination. The reuse of gold mill waste tailings can bring about economic, social, and environmental advantages. However, there are gaps that must be addressed to achieve a socially inclusive gold mill waste circularization. The utmost importance should be placed on the health and safety aspect, and it is advisable to carry out a comprehensive investigation into the degree to which hazardous substances are polluting the surrounding ecosystem, including the local community. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Age Differences in Expression of Generalized and Social Anxiety among Youth with Autism Spectrum Disorder

Author

Varela, R. Enrique, DuPont, Randolph, Kamps, Jodi L., Weems, Carl F., Niditch, Laura, Beaton, Elliott A., and Pucci, Gabriella

Abstract

This study examined differences in generalized and social anxiety symptoms across two age groups of children with autism spectrum disorder (ASD) while accounting for overall anxiety level, gender, and intellectual functioning. Older children (12-18 years) expressed more overall and social anxiety symptoms than younger children (6-11 years), and social anxiety symptoms were predominant in the older group. Younger children expressed more generalized anxiety symptoms than the older youth, and there was a trend for generalized anxiety symptoms to be more dominant in the younger group. Findings are consistent with theory of differential expression of specific anxiety symptoms across different ages seen with typically developing children, yet social evaluative concerns may be even stronger for adolescents with ASD.

Published
2020
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18. Culture Specific Influences on Anxiety in Latino Youth

Author

Varela, R. Enrique, Niditch, Laura A., Hensley-Maloney, Lauren, Moore, Kathryn W., Creveling, C. Christiane, and Jones, Kathryn M.

Abstract

Background: Accumulating evidence indicates that Latino children and adolescents are at risk for higher anxiety relative to youth of other ethnicities. However, to date, very little research has been conducted to examine culture specific mechanisms of anxiety in Latino youth. Objective: This study explored whether strict adherence to Latino cultural values emphasizing maintenance of group harmony, "familismo" and "simpatia," in combination with poor awareness and identification of negative emotions predicts increased anxiety among Latino youth. Method: "Familismo," "simpatia," poor emotion awareness, and anxiety were measured in a mixed clinically anxious (n = 27) and non-clinical (n = 20) sample of 7-13 year-old Latino children. Anxiety was measured through self-report and mother report. Results: Two way interactions between "familismo" and "simpatia," and between poor emotion awareness and "simpatia" predicted anxiety level. Graphs of the interactions indicated that the combination of high levels of each variable was associated with the highest levels of child-reported anxiety, while high "familismo" in the context of low "simpatia" was associated with low anxiety levels per child and parent report. In contrast, low "simpatia" in the context of poor emotion awareness was associated with low mother-reported child anxiety. Conclusions: Strict adherence to cultural values emphasizing family cohesion and positive interdependent social experiences in combination with poor emotion awareness are linked to anxiety in Latino youth.

Published
2019
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19. Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19

Author

Marto, J, Strambo, D, Ntaios, G, Nguyen, T, Herzig, R, Czlonkowska, A, Demeestere, J, Mansour, O, Salerno, A, Wegener, S, Baumgartner, P, Cereda, C, Bianco, G, Beyeler, M, Arnold, M, Carrera, E, Machi, P, Altersberger, V, Bonati, L, Gensicke, H, Bolognese, M, Peters, N, Wetzel, S, Magrico, M, Ramos, J, Sargento-Freitas, J, Machado, R, Maia, C, Machado, E, Nunes, A, Ferreira, P, Pinho E Melo, T, Dias, M, Paula, A, Correia, M, Castro, P, Azevedo, E, Albuquerque, L, Alves, J, Ferreira-Pinto, J, Meira, T, Pereira, L, Rodrigues, M, Araujo, A, Rocha, M, Pereira-Fonseca, A, Ribeiro, L, Varela, R, Malheiro, S, Cappellari, M, Zivelonghi, C, Sajeva, G, Zini, A, Gentile, M, Forlivesi, S, Migliaccio, L, Sessa, M, La Gioia, S, Pezzini, A, Sangalli, D, Zedde, M, Pascarella, R, Ferrarese, C, Beretta, S, Diamanti, S, Schwarz, G, Frisullo, G, Marcheselli, S, Seners, P, Sabben, C, Escalard, S, Piotin, M, Maier, B, Charbonnier, G, Vuillier, F, Legris, L, Cuisenier, P, Vodret, F, Marnat, G, Liegey, J, Sibon, I, Flottmann, F, Broocks, G, Gloyer, N, Bohmann, F, Schaefer, J, Nolte, C, Audebert, H, Siebert, E, Sykora, M, Lang, W, Ferrari, J, Mayer-Suess, L, Knoflach, M, Gizewski, E, Stolp, J, Stolze, L, Coutinho, J, Nederkoorn, P, Van Den Wijngaard, I, De Meris, J, Lemmens, R, De Raedt, S, Vandervorst, F, Rutgers, M, Guilmot, A, Dusart, A, Bellante, F, Calleja-Castano, P, Ostos, F, Gonzalez-Ortega, G, Martin-Jimenez, P, Garcia-Madrona, S, Cruz-Culebras, A, Vera, R, Matute, M, Fuentes, B, Alonso-De-Lecinana, M, Rigual, R, Diez-Tejedor, E, Perez-Sanchez, S, Montaner, J, Diaz-Otero, F, Perez-De-La-Ossa, N, Flores-Pina, B, Munoz-Narbona, L, Chamorro, A, Rodriguez-Vazquez, A, Renu, A, Ayo-Martin, O, Hernandez-Fernandez, F, Segura, T, Tejada-Meza, H, Sagarra-Mur, D, Serrano-Ponz, M, Hlaing, T, See, I, Simister, R, Werring, D, Kristoffersen, E, Nordanstig, A, Jood, K, Rentzos, A, Simunek, L, Krajickova, D, Krajina, A, Mikulik, R, Cvikova, M, Vinklarek, J, Skoloudik, D, Roubec, M, Hurtikova, E, Hruby, R, Ostry, S, Skoda, O, Pernicka, M, Jurak, L, Eichlova, Z, Jira, M, Kovar, M, Pansky, M, Mencl, P, Palouskova, H, Tomek, A, Jansky, P, Olserova, A, Sramek, M, Havlicek, R, Maly, P, Trakal, L, Fiksa, J, Slovak, M, Karlinski, M, Nowak, M, Sienkiewicz-Jarosz, H, Bochynska, A, Wrona, P, Homa, T, Sawczynska, K, Slowik, A, Wlodarczyk, E, Wiacek, M, Tomaszewska-Lampart, I, Sieczkowski, B, Bartosik-Psujek, H, Bilik, M, Bandzarewicz, A, Dorobek, M, Zielinska-Turek, J, Nowakowska-Kotas, M, Obara, K, Urbanowski, P, Budrewicz, S, Guzinski, M, Switonska, M, Rutkowska, I, Sobieszak-Skura, P, Labuz-Roszak, B, Debiec, A, Staszewski, J, Stepien, A, Zwiernik, J, Wasilewski, G, Tiu, C, Terecoasa, E, Radu, R, Negrila, A, Dorobat, B, Panea, C, Tiu, V, Petrescu, S, Ozdemir, A, Mahmoud, M, El-Samahy, H, Abdelkhalek, H, Al-Hashel, J, Ismail, I, Salmeen, A, Ghoreishi, A, Sabetay, S, Gross, H, Klein, P, Abdalkader, M, Jabbour, P, El Naamani, K, Tjoumakaris, S, Abbas, R, Mohamed, G, Chebl, A, Min, J, Hovingh, M, Tsai, J, Khan, M, Nalleballe, K, Onteddu, S, Masoud, H, Michael, M, Kaur, N, Maali, L, Abraham, M, Khandelwal, P, Bach, I, Ong, M, Babici, D, Khawaja, A, Hakemi, M, Rajamani, K, Cano-Nigenda, V, Arauz, A, Amaya, P, Llanos, N, Arango, A, Vences, M, Barrientos Guerra, J, Caetano, R, Martins, R, Scollo, S, Yalung, P, Nagendra, S, Gaikwad, A, Seo, K, Georgiopoulos, G, Nogueira, R, Michel, P, Marto J. P., Strambo D., Ntaios G., Nguyen T. N., Herzig R., Czlonkowska A., Demeestere J., Mansour O. Y., Salerno A., Wegener S., Baumgartner P., Cereda C. W., Bianco G., Beyeler M., Arnold M., Carrera E., Machi P., Altersberger V., Bonati L., Gensicke H., Bolognese M., Peters N., Wetzel S., Magrico M., Ramos J. N., Sargento-Freitas J., Machado R., Maia C., Machado E., Nunes A. P., Ferreira P., Pinho E Melo T., Dias M. C., Paula A., Correia M. A., Castro P., Azevedo E., Albuquerque L., Alves J. N., Ferreira-Pinto J., Meira T., Pereira L., Rodrigues M., Araujo A. P., Rocha M., Pereira-Fonseca A., Ribeiro L., Varela R., Malheiro S., Cappellari M., Zivelonghi C., Sajeva G., Zini A., Gentile M., Forlivesi S., Migliaccio L., Sessa M., La Gioia S., Pezzini A., Sangalli D., Zedde M., Pascarella R., Ferrarese C., Beretta S., Diamanti S., Schwarz G., Frisullo G., Marcheselli S., Seners P., Sabben C., Escalard S., Piotin M., Maier B., Charbonnier G., Vuillier F., Legris L., Cuisenier P., Vodret F. R., Marnat G., Liegey J. -S., Sibon I., Flottmann F., Broocks G., Gloyer N. -O., Bohmann F. O., Schaefer J. H., Nolte C., Audebert H. J., Siebert E., Sykora M., Lang W., Ferrari J., Mayer-Suess L., Knoflach M., Gizewski E. R., Stolp J., Stolze L. J., Coutinho J. M., Nederkoorn P., Van Den Wijngaard I., De Meris J., Lemmens R., De Raedt S., Vandervorst F., Rutgers M. P., Guilmot A., Dusart A., Bellante F., Calleja-Castano P., Ostos F., Gonzalez-Ortega G., Martin-Jimenez P., Garcia-Madrona S., Cruz-Culebras A., Vera R., Matute M. C., Fuentes B., Alonso-De-Lecinana M., Rigual R., Diez-Tejedor E., Perez-Sanchez S., Montaner J., Diaz-Otero F., Perez-De-La-Ossa N., Flores-Pina B., Munoz-Narbona L., Chamorro A., Rodriguez-Vazquez A., Renu A., Ayo-Martin O., Hernandez-Fernandez F., Segura T., Tejada-Meza H., Sagarra-Mur D., Serrano-Ponz M., Hlaing T., See I., Simister R., Werring D., Kristoffersen E. S., Nordanstig A., Jood K., Rentzos A., Simunek L., Krajickova D., Krajina A., Mikulik R., Cvikova M., Vinklarek J., Skoloudik D., Roubec M., Hurtikova E., Hruby R., Ostry S., Skoda O., Pernicka M., Jurak L., Eichlova Z., Jira M., Kovar M., Pansky M., Mencl P., Palouskova H., Tomek A., Jansky P., Olserova A., Sramek M., Havlicek R., Maly P., Trakal L., Fiksa J., Slovak M., Karlinski M. A., Nowak M., Sienkiewicz-Jarosz H., Bochynska A., Wrona P., Homa T., Sawczynska K., Slowik A., Wlodarczyk E., Wiacek M., Tomaszewska-Lampart I., Sieczkowski B., Bartosik-Psujek H., Bilik M., Bandzarewicz A., Dorobek M., Zielinska-Turek J., Nowakowska-Kotas M., Obara K., Urbanowski P., Budrewicz S., Guzinski M., Switonska M., Rutkowska I., Sobieszak-Skura P., Labuz-Roszak B. M., Debiec A., Staszewski J., Stepien A., Zwiernik J., Wasilewski G., Tiu C., Terecoasa E. O., Radu R. A., Negrila A., Dorobat B., Panea C., Tiu V., Petrescu S., Ozdemir A., Mahmoud M., El-Samahy H., Abdelkhalek H., Al-Hashel J., Ismail I. I., Salmeen A., Ghoreishi A., Sabetay S. I., Gross H., Klein P., Abdalkader M., Jabbour P., El Naamani K., Tjoumakaris S., Abbas R., Mohamed G. A., Chebl A., Min J., Hovingh M., Tsai J. P., Khan M., Nalleballe K., Onteddu S., Masoud H., Michael M., Kaur N., Maali L., Abraham M. G., Khandelwal P., Bach I., Ong M., Babici D., Khawaja A. M., Hakemi M., Rajamani K., Cano-Nigenda V., Arauz A., Amaya P., Llanos N., Arango A., Vences M. A., Barrientos Guerra J. D., Caetano R., Martins R. T., Scollo S. D., Yalung P. M., Nagendra S., Gaikwad A., Seo K. -D., Georgiopoulos G., Nogueira R. G., Michel P., Marto, J, Strambo, D, Ntaios, G, Nguyen, T, Herzig, R, Czlonkowska, A, Demeestere, J, Mansour, O, Salerno, A, Wegener, S, Baumgartner, P, Cereda, C, Bianco, G, Beyeler, M, Arnold, M, Carrera, E, Machi, P, Altersberger, V, Bonati, L, Gensicke, H, Bolognese, M, Peters, N, Wetzel, S, Magrico, M, Ramos, J, Sargento-Freitas, J, Machado, R, Maia, C, Machado, E, Nunes, A, Ferreira, P, Pinho E Melo, T, Dias, M, Paula, A, Correia, M, Castro, P, Azevedo, E, Albuquerque, L, Alves, J, Ferreira-Pinto, J, Meira, T, Pereira, L, Rodrigues, M, Araujo, A, Rocha, M, Pereira-Fonseca, A, Ribeiro, L, Varela, R, Malheiro, S, Cappellari, M, Zivelonghi, C, Sajeva, G, Zini, A, Gentile, M, Forlivesi, S, Migliaccio, L, Sessa, M, La Gioia, S, Pezzini, A, Sangalli, D, Zedde, M, Pascarella, R, Ferrarese, C, Beretta, S, Diamanti, S, Schwarz, G, Frisullo, G, Marcheselli, S, Seners, P, Sabben, C, Escalard, S, Piotin, M, Maier, B, Charbonnier, G, Vuillier, F, Legris, L, Cuisenier, P, Vodret, F, Marnat, G, Liegey, J, Sibon, I, Flottmann, F, Broocks, G, Gloyer, N, Bohmann, F, Schaefer, J, Nolte, C, Audebert, H, Siebert, E, Sykora, M, Lang, W, Ferrari, J, Mayer-Suess, L, Knoflach, M, Gizewski, E, Stolp, J, Stolze, L, Coutinho, J, Nederkoorn, P, Van Den Wijngaard, I, De Meris, J, Lemmens, R, De Raedt, S, Vandervorst, F, Rutgers, M, Guilmot, A, Dusart, A, Bellante, F, Calleja-Castano, P, Ostos, F, Gonzalez-Ortega, G, Martin-Jimenez, P, Garcia-Madrona, S, Cruz-Culebras, A, Vera, R, Matute, M, Fuentes, B, Alonso-De-Lecinana, M, Rigual, R, Diez-Tejedor, E, Perez-Sanchez, S, Montaner, J, Diaz-Otero, F, Perez-De-La-Ossa, N, Flores-Pina, B, Munoz-Narbona, L, Chamorro, A, Rodriguez-Vazquez, A, Renu, A, Ayo-Martin, O, Hernandez-Fernandez, F, Segura, T, Tejada-Meza, H, Sagarra-Mur, D, Serrano-Ponz, M, Hlaing, T, See, I, Simister, R, Werring, D, Kristoffersen, E, Nordanstig, A, Jood, K, Rentzos, A, Simunek, L, Krajickova, D, Krajina, A, Mikulik, R, Cvikova, M, Vinklarek, J, Skoloudik, D, Roubec, M, Hurtikova, E, Hruby, R, Ostry, S, Skoda, O, Pernicka, M, Jurak, L, Eichlova, Z, Jira, M, Kovar, M, Pansky, M, Mencl, P, Palouskova, H, Tomek, A, Jansky, P, Olserova, A, Sramek, M, Havlicek, R, Maly, P, Trakal, L, Fiksa, J, Slovak, M, Karlinski, M, Nowak, M, Sienkiewicz-Jarosz, H, Bochynska, A, Wrona, P, Homa, T, Sawczynska, K, Slowik, A, Wlodarczyk, E, Wiacek, M, Tomaszewska-Lampart, I, Sieczkowski, B, Bartosik-Psujek, H, Bilik, M, Bandzarewicz, A, Dorobek, M, Zielinska-Turek, J, Nowakowska-Kotas, M, Obara, K, Urbanowski, P, Budrewicz, S, Guzinski, M, Switonska, M, Rutkowska, I, Sobieszak-Skura, P, Labuz-Roszak, B, Debiec, A, Staszewski, J, Stepien, A, Zwiernik, J, Wasilewski, G, Tiu, C, Terecoasa, E, Radu, R, Negrila, A, Dorobat, B, Panea, C, Tiu, V, Petrescu, S, Ozdemir, A, Mahmoud, M, El-Samahy, H, Abdelkhalek, H, Al-Hashel, J, Ismail, I, Salmeen, A, Ghoreishi, A, Sabetay, S, Gross, H, Klein, P, Abdalkader, M, Jabbour, P, El Naamani, K, Tjoumakaris, S, Abbas, R, Mohamed, G, Chebl, A, Min, J, Hovingh, M, Tsai, J, Khan, M, Nalleballe, K, Onteddu, S, Masoud, H, Michael, M, Kaur, N, Maali, L, Abraham, M, Khandelwal, P, Bach, I, Ong, M, Babici, D, Khawaja, A, Hakemi, M, Rajamani, K, Cano-Nigenda, V, Arauz, A, Amaya, P, Llanos, N, Arango, A, Vences, M, Barrientos Guerra, J, Caetano, R, Martins, R, Scollo, S, Yalung, P, Nagendra, S, Gaikwad, A, Seo, K, Georgiopoulos, G, Nogueira, R, Michel, P, Marto J. P., Strambo D., Ntaios G., Nguyen T. N., Herzig R., Czlonkowska A., Demeestere J., Mansour O. Y., Salerno A., Wegener S., Baumgartner P., Cereda C. W., Bianco G., Beyeler M., Arnold M., Carrera E., Machi P., Altersberger V., Bonati L., Gensicke H., Bolognese M., Peters N., Wetzel S., Magrico M., Ramos J. N., Sargento-Freitas J., Machado R., Maia C., Machado E., Nunes A. P., Ferreira P., Pinho E Melo T., Dias M. C., Paula A., Correia M. A., Castro P., Azevedo E., Albuquerque L., Alves J. N., Ferreira-Pinto J., Meira T., Pereira L., Rodrigues M., Araujo A. P., Rocha M., Pereira-Fonseca A., Ribeiro L., Varela R., Malheiro S., Cappellari M., Zivelonghi C., Sajeva G., Zini A., Gentile M., Forlivesi S., Migliaccio L., Sessa M., La Gioia S., Pezzini A., Sangalli D., Zedde M., Pascarella R., Ferrarese C., Beretta S., Diamanti S., Schwarz G., Frisullo G., Marcheselli S., Seners P., Sabben C., Escalard S., Piotin M., Maier B., Charbonnier G., Vuillier F., Legris L., Cuisenier P., Vodret F. R., Marnat G., Liegey J. -S., Sibon I., Flottmann F., Broocks G., Gloyer N. -O., Bohmann F. O., Schaefer J. H., Nolte C., Audebert H. J., Siebert E., Sykora M., Lang W., Ferrari J., Mayer-Suess L., Knoflach M., Gizewski E. R., Stolp J., Stolze L. J., Coutinho J. M., Nederkoorn P., Van Den Wijngaard I., De Meris J., Lemmens R., De Raedt S., Vandervorst F., Rutgers M. P., Guilmot A., Dusart A., Bellante F., Calleja-Castano P., Ostos F., Gonzalez-Ortega G., Martin-Jimenez P., Garcia-Madrona S., Cruz-Culebras A., Vera R., Matute M. C., Fuentes B., Alonso-De-Lecinana M., Rigual R., Diez-Tejedor E., Perez-Sanchez S., Montaner J., Diaz-Otero F., Perez-De-La-Ossa N., Flores-Pina B., Munoz-Narbona L., Chamorro A., Rodriguez-Vazquez A., Renu A., Ayo-Martin O., Hernandez-Fernandez F., Segura T., Tejada-Meza H., Sagarra-Mur D., Serrano-Ponz M., Hlaing T., See I., Simister R., Werring D., Kristoffersen E. S., Nordanstig A., Jood K., Rentzos A., Simunek L., Krajickova D., Krajina A., Mikulik R., Cvikova M., Vinklarek J., Skoloudik D., Roubec M., Hurtikova E., Hruby R., Ostry S., Skoda O., Pernicka M., Jurak L., Eichlova Z., Jira M., Kovar M., Pansky M., Mencl P., Palouskova H., Tomek A., Jansky P., Olserova A., Sramek M., Havlicek R., Maly P., Trakal L., Fiksa J., Slovak M., Karlinski M. A., Nowak M., Sienkiewicz-Jarosz H., Bochynska A., Wrona P., Homa T., Sawczynska K., Slowik A., Wlodarczyk E., Wiacek M., Tomaszewska-Lampart I., Sieczkowski B., Bartosik-Psujek H., Bilik M., Bandzarewicz A., Dorobek M., Zielinska-Turek J., Nowakowska-Kotas M., Obara K., Urbanowski P., Budrewicz S., Guzinski M., Switonska M., Rutkowska I., Sobieszak-Skura P., Labuz-Roszak B. M., Debiec A., Staszewski J., Stepien A., Zwiernik J., Wasilewski G., Tiu C., Terecoasa E. O., Radu R. A., Negrila A., Dorobat B., Panea C., Tiu V., Petrescu S., Ozdemir A., Mahmoud M., El-Samahy H., Abdelkhalek H., Al-Hashel J., Ismail I. I., Salmeen A., Ghoreishi A., Sabetay S. I., Gross H., Klein P., Abdalkader M., Jabbour P., El Naamani K., Tjoumakaris S., Abbas R., Mohamed G. A., Chebl A., Min J., Hovingh M., Tsai J. P., Khan M., Nalleballe K., Onteddu S., Masoud H., Michael M., Kaur N., Maali L., Abraham M. G., Khandelwal P., Bach I., Ong M., Babici D., Khawaja A. M., Hakemi M., Rajamani K., Cano-Nigenda V., Arauz A., Amaya P., Llanos N., Arango A., Vences M. A., Barrientos Guerra J. D., Caetano R., Martins R. T., Scollo S. D., Yalung P. M., Nagendra S., Gaikwad A., Seo K. -D., Georgiopoulos G., Nogueira R. G., and Michel P.

Abstract

Background and Objectives COVID-19–related inflammation, endothelial dysfunction, and coagulopathy may increase the bleeding risk and lower the efficacy of revascularization treatments in patients with acute ischemic stroke (AIS). We aimed to evaluate the safety and outcomes of revascularization treatments in patients with AIS and COVID-19. Methods This was a retrospective multicenter cohort study of consecutive patients with AIS receiving intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) between March 2020 and June 2021 tested for severe acute respiratory syndrome coronavirus 2 infection. With a doubly robust model combining propensity score weighting and multivariate regression, we studied the association of COVID-19 with intracranial bleeding complications and clinical outcomes. Subgroup analyses were performed according to treatment groups (IVT-only and EVT). Results Of a total of 15,128 included patients from 105 centers, 853 (5.6%) were diagnosed with COVID-19; of those, 5,848 (38.7%) patients received IVT-only and 9,280 (61.3%) EVT (with or without IVT). Patients with COVID-19 had a higher rate of symptomatic intracerebral hemorrhage (SICH) (adjusted OR 1.53; 95% CI 1.16–2.01), symptomatic subarachnoid hemorrhage (SSAH) (OR 1.80; 95% CI 1.20–2.69), SICH and/or SSAH combined (OR 1.56; 95% CI 1.23–1.99), 24-hour mortality (OR 2.47; 95% CI 1.58–3.86), and 3-month mortality (OR 1.88; 95% CI 1.52–2.33). Patients with COVID-19 also had an unfavorable shift in the distribution of the modified Rankin score at 3 months (OR 1.42; 95% CI 1.26–1.60). Discussion Patients with AIS and COVID-19 showed higher rates of intracranial bleeding complications and worse clinical outcomes after revascularization treatments than contemporaneous non–COVID-19 patients receiving treatment. Current available data do not allow direct conclusions to be drawn on the effectiveness of revascularization treatments in patients with COVID-19 or to establish different treatment r

Published
2023

20. A Longitudinal Study of Inhibited Temperament, Effortful Control, Gender, and Anxiety in Early Childhood

Author

Niditch, Laura A. and Varela, R. Enrique

Abstract

Background: Temperament has been associated with child anxiety in a number of studies; however, research examining possible mechanisms of effect using longitudinal designs is scarce. Objective: This study tested a theoretically-derived model of anxiety development spanning infancy (6 months) to early childhood (approximately 72 months) that includes temperamental reactivity (i.e., behavioral inhibition), temperamental self-regulation (i.e., effortful control), and gender. Methods: Data used in this study were collected in phase I and phase II from 1226 children and their caregivers by the National Institute of Child Health and Human Development for their prospective, longitudinal Study of Early Child Care and Youth Development. Structural equation modeling procedures were used to test whether effortful control mediated the relation between behavioral inhibition and anxiety and whether such mediation varied by gender. Results: Results provided support for the model, suggesting that one mechanism linking the modest association between behavioral inhibition in infancy to anxiety symptoms in early childhood is through diminished effortful control. Further, moderated mediation analyses indicated that this mechanism was apparent only for girls. Conclusions: Modulation of temperamental reactivity via effortful control may be a protective factor in the translation of early behavioral inhibition to childhood anxiety for girls.

Published
2018
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22. Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial

Author

Abdelhamid, N, Abdul Rahman, D, Abdul-Saheb, M, Abreu, P, Abroskina, M, Abu Ahmad, F, Accassat, S, Acciaresi, M, Adami, A, Ahmad, N, Ahmed, F, Alberto Hawkes, M, Alemseged, F, Ali, A, Altavilla, R, Alwis, L, Amarenco, P, Amaro, S, Amaya Sanchez, LE, Amelia Pinto, A, Ameriso, SF, Amin, H, Amino, T, Amjad, AK, Anagnostou, E, Andersen, G, Anderson, C, Anderson, DC, Andrea Falco, M, Andres Mackinnon, F, Andreu, D, Androulakis, M, Angel Gamero, M, Angel Saredo, G, Angeles Diaz, R, Angels Font, M, Anticoli, S, Arauz, A, Arauz Gongora, AA, Araya, P, Arenillas Lara, JF, Arias Rivas, S, Arnold, M, Augustin, S, Avelar, W, Azevedo, E, Babikian, V, Bacellar, A, Badalyan, K, Bae, HJ, Baez Martinez, EM, Bagelmann, H, Bailey, P, Bak, Z, Baker, M, Balazs, A, Baldaranov, D, Balogun, I, Balueva, T, Bankuti, Z, Bar, M, Baranowska, A, Bardutzky, J, Barker Trejo, S, Barlinn, J, Baronnet, F, Barroso, C, Barteys, M, Bartolottiova, T, Barulin, A, Bas, M, Bashir, S, Basile, V, Bathe-Peters, R, Bathula, R, Batista, C, Batur Caglayan, H, Baumgartner, P, Bazan, R, Bazhenova, O, Beaudry, M, Beer, J, Behnam, Y, Beilei, C, Beinlich, A, Bejot, Y, Belkin, A, Benavente, OR, Benjamin, A, Berardi, V, Bereczki, D, Berkowitz, SD, Berlingieri, J, Berrios, W, Berrouschot, J, Bhandari, M, Bhargavah, M, Bicker, H, Bicsak, T, Bilik, M, Bindila, D, Birchenall, J, Birnbaum, L, Black, T, Blacker, D, Blacquiere, D, Blanc-Labarre, C, Blank, C, Blazejewska-Hyzorek, B, Bloch, S, Bodiguel, E, Bogdanov, E, Boos, L, Borcsik, L, Bornstein, N, Bouly, S, Braga, G, Bragado, I, Bravi, MC, Brokalaki, C, Brola, W, Brouns, R, Bruce, D, Brzoska-Mizgalska, J, Buck, B, Buksinska-Lisik, M, Burke, J, Burn, M, Bustamante, G, Cabrejo, L, Cai, K, Cajaraville, S, Calejo, M, Calvet, D, Campillo, J, Campos Costa, E, Camps, P, Can Alaydin, H, Candeloro, E, Canepa, C, Cantu Brito, CG, Cappellari, M, Carcel, C, Cardona Portela, P, Cardoso, F, Carek, M, Carletti, M, Carlos Portilla, J, Caruso, P, Casado-Naranjo, I, Castellini, P, Castro, D, Castro Meira, F, Cavallini, A, Cayuela Caudevilla, N, Cenciarelli, S, Cereda, C, Cerrone, P, Chakrabarti, A, Chaloulos-Iakovidis, P, Chamorro, A, Chandrasena, D, Chang, DI, Che, C, Chembala, J, Chen, J, Chen, Z, Chen, T, Chen, H, Chen, X, Chen, G, Chen, L, Chen, S, Cheripelli, B, Chin, M, Chiquete Anaya, E, Chorazy, M, Christensen, H, Christensen, T, Christian, L, Chu, F, Chung, CS, Clark, W, Clarke, R, Claverie, S, Clemente Agostoni, E, Clissold, B, Coelho, J, Cohen, D, Colakoglu, S, Collas, D, Condurso, R, Connolly, SJ, Consoli, D, Constantin, C, Constantino Silva, AB, Contardo, L, Corlobe, A, Correia, M, Correia, C, Cortijo Garcia, E, Coull, B, Coutts, S, Coveney, S, Cras, P, Crols, R, Crozier, S, Csanyi, A, Csiba, L, Csontos, K, Csuha, R, Cui, L, Cunha, L, Curtze, S, Czerska, M, Czlonkowska, A, Czurko, M, Czuryszkiewicz, M, Dagnino, M, Dai, C, Daineko, A, Dalek, G, Damgaard, D, Danese, A, Dani, K, Danku, V, Dario Toledo, W, Dávalos, A, De Havenon, A, De Keyser, J, De Klippel, N, De La Torre, J, De Pauw, A, De Smedt, A, De Torres, R, De Vries Basson, MM, Dearborn, J, Deganutto, R, Degeorgia, M, Deguchi, I, Del Giudice, A, Delcourt, C, Delgado-Mederos, R, Della Marca, G, Delpont, B, Deltour, S, Demets, DL, Dennis, M, Desai, J, Devine, J, Dhollander, I, Di Mascio, MT, Diaconu, M, Diaz Otero, F, Dietzel, J, Diez-Tejedor, E, Ding, N, Ding, J, Diomedi, M, Dioszeghy, P, Distefano, M, Domigo, V, Dorodnicov, E, Dossi, D, Doubal, F, Druzenko, I, Du, P, Du, J, Duman, T, Duodu, Y, Dutta, D, Dylewicz, L, Eckstein, J, Ehrensperger, E, Ehrlich, S, Einer Allende, G, Elena Halac, B, Elyas, S, Endres, M, Engelbrecht, JM, Engelter, S, Epinat, M, Eren, F, Esbjornsson, M, Escribano, B, Escudero, I, Esisi, B, Essa, B, Esterbauer, M, Evans, N, Eveson, D, Fabio, S, Fang, L, Fanta, S, Fares, M, Fatar, M, Faust, K, Favate, A, Fazekas, F, Federica Denaro, M, Fedin, A, Felipe Amaya, P, Feng, J, Ferencova, K, Fernanda Gilli, M, Fernandez, MD, Fernandez Pirrone, PN, Fernandez Vera, J, Ferrari, J, Ferreira, A, Ferreira Junior, G, Fidler, M, Field, D, Field, T, Figueroa, C, Fiksa, J, Filipov, A, Firstenfeld, A, Fisch, L, Fischer, U, Fisselier, M, Fiszer, U, Fluri, F, Fortea, G, Fotherby, K, Fraczek, A, France, E, Freitas, G, Frey, S, Frick, M, Friedman, A, Friedrich, M, Frisullo, G, Fryze, W, Fuentes Gimeno, B, Fujigasaki, H, Fukuyama, K, Furlan, A, Furlanis, G, Furnace, J, Gabriel, M, Gabriel Reich, E, Gagliardi, RJ, Galati, F, Galli Giqueauk, E, Gallina, A, Gallinella, E, Gallo, J, Gangadharan, S, Gao, Y, Garcia Lopez, R, Garcia Pastor, A, Garcia Sanchez, SM, Garnauf, M, Garnier, P, Gasecki, D, Gasic, K, Gasiorek, K, Gasser, S, Gaugg, M, Gebreyohanns, M, Gebura, K, Geng, J, Geniz Clavijo, M, Georg Haeusler, K, Geran, R, Geremek, M, Gerocs, Z, Ghia, D, Giannandrea, D, Giatsidis, F, Gien Lopez, JA, Gil Nunez, A, Gimenez, L, Giralt, E, Glabinski, A, Gladstone, D, Gliem, M, Gluszkiewicz, M, Goddeau, R, Gogoleva, E, Gokce, M, Goldemund, D, Golikov, K, Gomes Neto, A, Gomez Schneider, M, Gomez-Choco, M, Gomis, M, Gongora-Rivera, JF, Gonysheva, Y, Gonzalez, L, Gonzalez Toledo, ME, Gottschal, M, Gozdzik, I, Grabowski, S, Graf, S, Green, D, Greer, D, Gregorio, T, Greisenegger, S, Greshnova, I, Griebe, M, Grzesik, M, Guan, J, Guarda, S, Gueguen, A, Guidoux, C, Guillermo Povedano, P, Guillon, B, Guiraudg, V, Gunathilagan, G, Guryanova, N, Gusev, V, Gustavo Persi, G, Gutiérrez, R, Guyler, P, Gyuker, N, Hachinski, V, Hajas, A, Hallevi, H, Hankey, G, Hankey, GJ, Hanouskova, L, Hao, L, Haraguchi, K, Haralur Sreekantaiah, Y, Haratz, S, Hargroves, D, Harkness, K, Harmel, P, Harrasser, M, Hart, RG, Harvey, M, Hasan, R, Hasegawa, Y, Hassan, A, Hattori, M, Hatzitolios, A, Hauk, M, Hayashi, T, Hayhoe, H, Hedna, VS, Heine, M, Held, V, Hellwig, S, Henkner, J, Henninger, N, Hermans, S, Hernandez, J, Herrero, D, Hervieu-Begue, M, Herzig, R, Hicken, L, Hieber, M, Hill, M, Hirose, M, Hobeanu, MC, Hobson, B, Hochstetter, M, Hoe Heo, J, Hoffmann, M, Holmstedt, C, Hon, P, Hong, KS, Honma, Y, Horev, A, Horgan, G, Horvath, L, Horvath, M, Hoyer, C, Huang, D, Huang, H, Huber, B, Huhtakangas, J, Hussain, M, Igarashi, S, Iglesias Mohedano, AM, Ignacio Tembl, J, Impellizzeri, M, Inanc, Y, Ioli, P, Irina Aniculaesei, A, Ishida, K, Itabashi, R, Iversen, H, Jagolino, A, Jakab, K, Jander, S, Janka, H, Jankovych, J, Jansen, J, Jasek, L, Javier Alet, M, Javor, L, Jin, X, Jing, P, Joachim, B, Joan Macleod, M, Johnson, M, Jose Martin, J, Joyner, C, Judit Szabo, K, Jun-Oconnell, A, Jura, R, Kaczorowska, B, Kadlcikova, J, Kahles, T, Kakaletsis, N, Kakuk, I, Kalinowska, K, Kaminska, K, Kaneko, C, Kanellos, I, Kapeller, P, Kapica-Topczewska, K, Karasz, O, Karlinski, M, Karlsson, JE, Kasa, K, Kashaeva, E, Kasner, SE, Kaste, M, Kasza, J, Katalin Iljicsov, A, Katsurayama, M, Kaur, S, Kawanishi, M, Kaygorodtseva, S, Ke, K, Kei, A, Keilitz, J, Kellner, J, Kelly, P, Kelly, S, Kemlink, D, Kerekgyarto, M, Keskinarkaus, I, Khairutdinova, D, Khanna, A, Khaw, A, Kholopov, M, Khoumri, C, Kirpicheva, S, Kirshner, H, Kitagawa, K, Kittner, S, Kivioja, R, Klein, F, Kleindorfer, D, Kleinig, T, Klivenyi, P, Knecht, S, Kobayashi, Y, Kobayashi, A, Koch, M, Koehler, L, Koivu, M, Kolianov, V, Koltsov, I, Kondo, T, Konkov, I, Kopecky, S, Korompoki, E, Korpela, J, Kosarz-Lanczek, K, Koutroubi, A, Kovacs, K, Kovacs, T, Kovacs, H, Kowalczyk, K, Kowalska, M, Krajickova, D, Kral, M, Krarup Hansen, C, Kraska, J, Krebs, S, Krejci, V, Kremer, C, Kreuzpointer, R, Krzyzanowska, M, Kucken, D, Kulakowska, A, Kunzmann, J, Kurenkova, N, Kuris, A, Kurkowska-Jastrzebska, I, Kurtenkova, N, Kurushina, O, Kusnick, G, Kustova, M, Kuwashiro, T, Kwan Cha, J, Lago, A, Lagutenko, M, Lajos, B, Lambeck, J, Lamy, C, Landolfi, A, Lanfranconi, S, Lang, W, Lara Lezama, LB, Lara Rodriguez, B, Largo, T, Lasek-Bal, A, Latte, L, Lauer, V, Lavados, P, Le Bouc, R, Leal Cantu, R, Lechner, H, Lecouturier, K, Leder, S, Lee, J, Lee, BC, Leger, A, Leira, E, Leisse, I, Leker, R, Lembo, G, Lenskaya, L, Leyden, J, Li, G, Li, M, Li, S, Li, J, Liamis, G, Liang, H, Liang, Z, Ligot, N, Lin, H, Lindert, R, Lindgren, A, Linna, M, Litwin, T, Liu, K, Liu, X, Llull, L, Lohninger, B, Longoni, M, Loomis, C, Lopes, D, Lopez Fernandez, M, Lopez Garza, N, Lord, A, Louw, S, Lovasz, R, Lowenkopf, T, Lu, Z, Lubke-Detring, SC, Luder, R, Lujan, S, Luo, B, Lupinogina, L, Luschin, G, Lutsep, H, Lvova, A, Ly, J, Grosse, G.M., Ma, H, Ma, C, Machado, M, Machado, C, Macher, S, Machetanz, J, Macian-Montoro, F, Mackey, E, Mackey, A, Maclean, G, Maestre-Moreno, J, Magadan, A, Magyar, T, Mahagney, A, Majid, A, Majjhoo, A, Makaritsis, K, Mandzia, J, Mangas Guijarro, M, Mangion, D, Manios, E, Mann, S, Manning, L, Manno, C, Manuel Garcia, J, Maqueda, V, Mar Castellanos, M, Mar Freijo, M, Marando, C, Marcela Lepera, S, Marcos Couto, J, Maria Bruera, G, Maria Greco, L, Maria Lorenzo, A, Maria Obmann, S, Maria Roa, A, Marini, C, Marinkovic, I, Mario Sumay, G, Mario Torres, C, Marko, M, Markova, S, Markus, H, Marsh, R, Marsili, E, Marta Esnaola, M, Marta Moreno, J, Marti-Fabregas, J, Martina Angelocola, S, Martínez Sánchez, P, Martinez-Majander, N, Martins, S, Marzelik, O, Mastrocola, S, Matamala, G, Matoltsy, A, Matosevic, B, Matsumoto, S, Maud, A, Mauri Cabdevila, G, May, Z, Mayasi, Y, Mayr, A, Mazzoli, T, Mcarthur, K, Mccullough, L, Medina Pech, CE, Medlin, F, Mehdiratta, M, Mehta, S, Mehta, D, Mehta, B, Melis, M, Melnikova, E, Mendez, B, Mendonca, T, Mengual Chirifie, JJ, Menon, N, Mensch, A, Meseguer, E, Messe, S, Metcalf, K, Meyer, N, Michas, F, Micheletti, N, Mikulik, R, Milionis, H, Miller, B, Milling, T, Minelli, C, Minhas, J, Minns, M, Mircea, D, Mishra, S, Mismas, A, Mistri, A, Mitrovic, N, Miyake, H, Modrau, B, Moey, A, Molina, C, Molina, J, Molis, A, Moller, J, Molnar, S, Moniche, F, Monosi, C, Monzani, V, Moonis, M, Morais, R, Morales, L, Morales, A, Morar-Precup, D, Moreton, F, Moro, C, Morozova, E, Morton, M, Morvan, T, Morvan, E, Motko, T, Mowla, A, Mozhejko, E, Muddegowda, G, Mudhar, O, 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Papadopoulou, E, Papagiannis, A, Papavasileiou, V, Papina, M, Pardo De Donlebun, JR, Parisi, V, Park, JM, Pasten, J, Patel, N, Pavlik, O, Pawelczyk, M, Peacock, WF, Pei, H, Peisker, T, Pena Sedna, LF, Penn, A, Pentek, S, Pepper, E, Pereira, L, Perera, K, Perez, Y, Perez, S, Perez Leguizamon, P, Pernicka, M, Perry, R, Persico, A, Pesant, Y, Peska, S, Peters, D, Peters, G, Pettigrew, L, Phan, T, Philippi, S, Phinney, T, Pico, F, Pidal, A, Piechowski-Jozwiak, B, Pieroni, A, Pineiro, S, Piras, V, Pizova, N, Polanco, J, Polin, M, Polyakov, A, Polychronopoulou, E, Polymeris, A, Popov, D, Poppe, A, Postorino, P, Pozzerese, C, Pradhan, M, Prats, L, Prazdnichkova, E, Prendl, B, Pretorius, M, Profice, P, Prokopenko, S, Pudov, E, Pujol Lereis, V, Punzo Bravo, G, Purroy, F, Qiu, J, Qu, X, Quenardelle, V, Quesada Garcia, H, Radrizzani, L, Radtke, A, Raffelsberger, T, Ramirez Moreno, JM, Ramos-Estebanez, C, Rani, A, Rapantova, P, Rashed, K, Rasheed Nihara, A, Rasmussen, J, Redondo Robles, L, Reif, M, Reiner, P, Rekova, P, Renu, A, Repetto, M, Reyes, P, Reyes Morales, S, Rha, JH, Ribeiro, J, Ricci, S, Richard, C, Rigual, R, Rinaldi, C, Riveira Rodriguez, C, Rizzato, B, Robinson, TG, Rocco, A, Rodrigues, M, Rodriguez, G, Rodriguez Campello, A, Rodriguez Lucci, F, Rodriguez Yanez, M, Roesler, C, Roffe, C, Roine, R, Roine, S, Roldan, A, Romana Pezzella, F, Romano, M, Roos, JS, Rosso, C, Rostrup Kruuse, C, Roth, Y, Roukens, R, Roveri, L, Rozanski, D, Rozniecki, J, Rozsa, C, Rudilosso, S, Ruiz Ares, G, Ruiz Franco, A, Rum, G, Ruuskanen, J, Rybinnik, I, Ryota, K, Saarinen, J, Saavedra, V, Sabben, C, Sabet, A, Sagris, D, Sahlas, J, Sakai, N, Salamanca, P, Salgado, P, Salig, S, Salletmayr, T, Salnikov, M, Samoshkina, O, Samson, Y, Sanak, D, Sànchez Cerón, M, Santalucia, P, Santamaria Cadavid, M, Santiago, P, Santo, G, Sanz Cuesta, B, Sargento, J, Sarraj, A, Sas, K, Sas, A, Satoshi, O, Satsoglou, S, Sattar, N, Savitz, S, Savopoulos, C, Saw, J, Sawicka, M, Sawyer, R, Scandura, T, Schillinger, N, Schindler, J, Schlachetzki, F, Schneider, I, Schuppner, R, Schurig, J, Schwarzbach, CJ, Sebejova, M, Seidel, G, Sekaran, L, Selcuk, D, Selvarajah, J, Semerano, A, Semjen, J, Semushina, D, Sen, S, Seok Park, M, Serena, J, Serhat Tokgoz, O, Serles, W, Serrano, F, Sevin, M, Seynaeve, L, Shah, S, Shamalov, N, Shang, T, Sharma, M, Sharrief, A, Shazam Hussain, M, Shchukin, I, Shen, W, Shepeleva, E, Shinsuke, I, Shmonin, A, Shoamanesh, A, Shuaib, A, Shulga, A, Sibolt, G, Sibon, I, Sicilia, I, Siebert, M, Sieczkowska, E, Sila, C, Silva, AA, Silva, D, Silva, P, Silva, Y, Silvestrini, M, Simony, Z, Simpkins, A, Singh, B, Sinha, D, Sipos, I, Skoda, O, Skowron, P, Skowronska, M, Sliwinska, B, Slonkova, J, Smolkin, A, Smyth, A, Sobolewski, P, Sobota, A, Sohn, SI, Soldatov, M, Solganov, I, Soloveva, L, Solovyeva, E, Sonntag, N, Soors, P, Sorgun, M, Soriano, C, Spence, D, Spengos, K, Sposato, L, Staaf, G, Stadler, K, Stakhovskaya, L, Stamatelopoulos, K, Steinert, S, Stetkarova, I, Stiehm, M, Stocker, R, Stoinski, J, Stoll, A, Stotts, G, Stumpp, A, Sucapane, P, Suenaga, T, Sun, X, Sundararajan, S, Sung Kim, J, Suzuki, H, Svaneborg, N, Szasz, G, Szczuchniak, W, Szczyrba, S, Szegedi, N, Szekely, A, Szewczyk, Z, Szilagyi, G, Szlufik, S, Szoboszlai, K, Szpisjak, L, Sztajzel, R, Sztriha, L, Ta Wil, SE, Taggeselle, J, Takamatsu, K, Takao, M, Taki, W, Takizawa, S, Talahma, M, Tamayo, A, Tan, J, Tanne, D, Tapanainen, A, Tapiola, T, Tarasiuk, J, Tatlisumak, T, Tayal, A, Tcvetkova, S, Teal, P, Tejada Garcia, J, Tejada Meza, H, Tenora, D, Terceno, M, Terentiou, A, Tezcan, S, Thaler, D, Thomson, A, Thouvenot, E, Tiainen, M, Timberg, I, Timsit, S, Tinchon, A, Tirschwell, D, Togay Isikay, C, Tokunaga, K, Tolino, M, Toloza, C, Tomelleri, G, Tomoyuki, K, Tomppo, LM, Tong, Z, Tong, L, Toni, D, Torres, J, Tossavainen, C, Toth, G, Tountopoulou, A, Touze, E, Tovar, M, Toyoda, K, Trillo, S, Trommer, A, Tropepi, D, Tryambake, D, Tu, H, Tuetuencue, S, Tumova, R, Tumpula, O, Turc, G, Tutaj, A, Tynkkynen, J, Uchiyama, S, Uchwat, U, Uhrinyakova, L, Ulku Acar, R, Uluduz Ugurlu, D, Urra, X, Urui, S, Usero Ruiz, M, Vaclavik, D, Vahedi, K, Valikovics, A, Valpas, J, Van Acker, P, Van Daele, W, Vanderschueren, G, Vanina Jure, L, Varela, R, Varga, Z, Varvat, J, Varvyanskaya, N, Vasco Salgado, A, Vasko, P, Vass, L, Vassilopoulou, S, Vastagh, I, Vazquez, P, Vecsei, L, Veltkamp, R, Venti, M, Verdugo, M, Verocai, V, Veronica Marroquin, M, Veronica Simonsini, C, Veverka, T, Vigl, M, Vila, A, Vilar, C, Villanueva Osorio, JA, Virta, J, Vitkova, E, Voglsperger, B, Volna, J, Von Weitzel-Mudersbach, PA, Vora, N, Voznyuk, I, Wach-Klink, A, Wacongne, A, Walters, D, Wang, Y, Wang, J, Wang, L, Wang, X, Wang, W, Wang, N, Wang, D, Wang, H, Warnack, W, Wartenberg, K, Waters, R, Waters, M, Webb, T, Weber, J, Weiss, G, Weissenborn, K, Weitz, JI, Weller, B, Wen, G, Weng, G, Werner, P, Werring, D, Wester, P, Whiteley, W, Whiting, R, Wijeratne, T, Willems, C, Wilson, L, Wilson, C, Winder, T, Windt, J, Winkler, A, Winska-Tereszkiewicz, A, Wisniewska, A, Wittayer, M, Wlodek, A, Wojnarowska-Arendt, A, Wolf, M, Wolff, V, Wolter, C, Wong, A, Wook Nah, H, Worthmann, H, Wu, W, Wu, S, Wunderlich, S, Wurzinger, H, Wyse, DG, Xiao, B, Xiaopeng, W, Ximenez-Carrillo, A, Xiong, L, Xiong, Y, Xiong, W, Xu, Y, Xu, J, Xu, Z, Yalo, B, Yamada, T, Yamasaki, M, Yang, L, Yang, Y, Yang, X, Yang, Q, Yang, B, Yang, J, Yasuhiro, I, Yee Lam, M, Yegappan, C, Yip, S, Ylikallio, E, Ylikotila, P, Yongwon Jin, A, Yoon, BW, Yoshida, Y, Yperzeele, L, Yuan, H, Yuasa, H, Zalewska, J, Zanferrari, C, Zapata, E, Zboznovits, D, Zelenka, I, Zhang, C, Zhang, B, Zhang, S, Zhang, M, Zhang, X, Zhang, J, Zhao, L, Zhirnova, O, Zhou, L, Zielinska-Turek, J, Zinchenko, I, Ziomek, M, Zitzmann, A, Zweifler, R, Zwiernik, J, Kasner, Scott E, Swaminathan, Balakumar, Lavados, Pablo, Sharma, Mukul, Muir, Keith, Veltkamp, Roland, Ameriso, Sebastian F, Endres, Matthias, Lutsep, Helmi, Messé, Steven R, Spence, J David, Nedeltechev, Krassen, Perera, Kanjana, Santo, Gustavo, Olavarria, Veronica, Lindgren, Arne, Bangdiwala, Shrikant, Shoamanesh, Ashkan, Berkowitz, Scott D, Mundl, Hardi, Connolly, Stuart J, and Hart, Robert G

Published
2018
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29. Fossil methane source dominates Cariaco Basin water column methane geochemistry

Author

Kessler, JD, Reeburgh, WS, Southon, J, and Varela, R

Subjects
Meteorology & Atmospheric Sciences
Abstract

Natural radiocarbon measurements on methane (14C-CH4) extracted from the Cariaco Basin water column show that 98% of the methane in Cariaco Basin waters is derived from fossil (radiocarbon-free) sources. Previous work on Cariaco Basin methane (CH4) considered only a diagenetic sediment source. Similar measurements of sediment 14C-CH4 indicate that sediment CH4 is produced from modern particulate material; thus the sediment and water column CH4 have distinct sources. Using time-dependent CH4 geochemical box models which include a fossil seep CH4 source term, we estimate 1) 0.024-0.028 Tg y-1 of seep CH4 are added to the Cariaco Basin water column, 2) the water column CH4 will reach a steady-state concentration by the year 2065, and 3) the seep CH4 inputs possibly began in 1967, following the July 30 Caracas earthquake. Oxidizing this CH4 to dissolved inorganic carbon does not appear to affect Cariaco Basin 14C chronologies. Copyright 2005 by the American Geophysical Union.

Published
2005

30. Embolización de aneurismas intracraneales múltiples en sesión única

Author

Vargas-Urbina, John F., Martinez Silva, R.E., Saal-Zapata, Giancarlo, Rodríguez Varela, R., Durand-Castro, Walter S., Flores Quijaite, J., Vargas-Urbina, John F., Martinez Silva, R.E., Saal-Zapata, Giancarlo, Rodríguez Varela, R., Durand-Castro, Walter S., and Flores Quijaite, J.

Abstract

Objective: To determine clinical and angiographical outcomes in patients with multiple intracranial aneurysms who underwent endovascular therapy in a single session. Materials and Methods: Patients older than 18 years with multiple (≥2) ruptured or non-ruptured aneurysms were included, and all of them underwent endovascular therapy in a single session between 2019 and 2021. Clinical and angiographic data was collected. Immediate occlusion and follow-up data were collected. Rankin modified scale was used for assessing clinical outcomes. Results: Twenty-five patients were treated, and fourteen had subarachnoid hemorrhage. Seventy-eight aneurysms were diagnosed, and 59 of them were treated. The most frequent location was at the ophthalmic segment. Maximum average height was 5.2- mm, which showed significant statistical difference with a ruptured condition (p≤0.02). The main modality for endovascular therapy was the remodeling technique, which was used in 39% of all cases. Immediate Raymond Roy staging was I in 60% of all cases, and IIIa in 35% of all cases. Complication rate was 24%, and mortality rate was 8%. Conclusions: Single session endovascular therapy is an effective and safe option for cases of multiple intracranial aneurysms in our institution. Occlusion and complication rates were acceptable., Objetivo: Determinar los resultados clínicos y angiográficos en pacientes con aneurismas intracraneales múltiples tratados endovascularmente en una única sesión. Materiales y Métodos: Se incluyó a todos los pacientes mayores de 18 años con aneurismas múltiples (≥2), rotos o no rotos, tratados con terapia endovascular en una única sesión entre 2019 y 2021. Se recolectaron los datos clínicos y angiográficos. Se determinó la tasa de oclusión inmediata y del seguimiento. La escala de Rankin modificado se usó para valorar el resultado clínico. Resultados: Se trataron 25 pacientes, de los cuales 14 se presentaron con hemorragia subaracnoidea. Se diagnosticaron un total de 78 aneurismas, de los cuales 59 aneurismas fueron tratados. La localización más frecuente fue el segmento oftálmico. La altura máxima promedio fue de 5.2mm, lo cual tuvo diferencia estadística significativa con el estado de ruptura (p ≤ 0.02). El principal tipo de tratamiento endovascular fue la técnica de remodeling en el 39 % de casos. El Raymond Roy inmediato fue I en el 60 % y IIIa en el 35 % de casos. La tasa de complicaciones fue del 24 % y de mortalidad fue del 8 %. Conclusiones: El tratamiento endovascular en una única sesión es una opción efectiva y segura en casos de aneurismas intracraneales múltiples en nuestra institución con tasa de oclusión y complicaciones aceptable.

Published
2023

31. Computational approaches to Explainable Artificial Intelligence: Advances in theory, applications and trends

Author

Universidad de Alicante. Departamento de Tecnología Informática y Computación, Górriz, J.M., Álvarez-Illán, I., Álvarez-Marquina, A., Arco, J.E., Atzmueller, M., Ballarini, F., Barakova, E., Bologna, G., Bonomini, P., Castellanos-Dominguez, G., Castillo-Barnes, D., Cho, S.B., Contreras, R., Cuadra, J.M., Domínguez, E., Domínguez-Mateos, F., Duro, R.J., Elizondo, D., Fernández-Caballero, A., Fernandez-Jover, E., Formoso, M.A., Gallego-Molina, N.J., Gamazo, J., García González, J., Garcia-Rodriguez, Jose, Garre, C., Garrigós, J., Gómez-Rodellar, A., Gómez-Vilda, P., Graña, M., Guerrero-Rodriguez, B., Hendrikse, S.C.F., Jimenez-Mesa, C., Jodra-Chuan, M., Julián, Vicente, Kotz, G., Kutt, K., Leming, M., Lope, J. de, Macas, B., Marrero-Aguiar, V., Martinez, J.J., Martinez-Murcia, F.J., Martínez-Tomás, R., Mekyska, J., Nalepa, G.J., Novais, Paulo, Orellana, D., Ortiz, A., Palacios-Alonso, Daniel, Palma, J., Pereira, A., Pinacho-Davidson, P., Pinninghoff, M.A., Ponticorvo, M., Psarrou, A., Ramírez, J., Rincón, M., Rodellar-Biarge, V., Rodríguez-Rodríguez, I., Roelofsma, P.H.M.P., Santos, J., Salas-Gonzalez, D., Salcedo-Lagos, P., Segovia, F., Shoeibi, A., Silva, M., Simic, D., Suckling, J., Treur, J., Tsanas, A., Varela, R., Wang, S.H., Wang, W., Zhang, Y.D., Zhu, H., Zhu, Z., Ferrández-Vicente, J.M., Universidad de Alicante. Departamento de Tecnología Informática y Computación, Górriz, J.M., Álvarez-Illán, I., Álvarez-Marquina, A., Arco, J.E., Atzmueller, M., Ballarini, F., Barakova, E., Bologna, G., Bonomini, P., Castellanos-Dominguez, G., Castillo-Barnes, D., Cho, S.B., Contreras, R., Cuadra, J.M., Domínguez, E., Domínguez-Mateos, F., Duro, R.J., Elizondo, D., Fernández-Caballero, A., Fernandez-Jover, E., Formoso, M.A., Gallego-Molina, N.J., Gamazo, J., García González, J., Garcia-Rodriguez, Jose, Garre, C., Garrigós, J., Gómez-Rodellar, A., Gómez-Vilda, P., Graña, M., Guerrero-Rodriguez, B., Hendrikse, S.C.F., Jimenez-Mesa, C., Jodra-Chuan, M., Julián, Vicente, Kotz, G., Kutt, K., Leming, M., Lope, J. de, Macas, B., Marrero-Aguiar, V., Martinez, J.J., Martinez-Murcia, F.J., Martínez-Tomás, R., Mekyska, J., Nalepa, G.J., Novais, Paulo, Orellana, D., Ortiz, A., Palacios-Alonso, Daniel, Palma, J., Pereira, A., Pinacho-Davidson, P., Pinninghoff, M.A., Ponticorvo, M., Psarrou, A., Ramírez, J., Rincón, M., Rodellar-Biarge, V., Rodríguez-Rodríguez, I., Roelofsma, P.H.M.P., Santos, J., Salas-Gonzalez, D., Salcedo-Lagos, P., Segovia, F., Shoeibi, A., Silva, M., Simic, D., Suckling, J., Treur, J., Tsanas, A., Varela, R., Wang, S.H., Wang, W., Zhang, Y.D., Zhu, H., Zhu, Z., and Ferrández-Vicente, J.M.

Abstract

Deep Learning (DL), a groundbreaking branch of Machine Learning (ML), has emerged as a driving force in both theoretical and applied Artificial Intelligence (AI). DL algorithms, rooted in complex and non-linear artificial neural systems, excel at extracting high-level features from data. DL has demonstrated human-level performance in real-world tasks, including clinical diagnostics, and has unlocked solutions to previously intractable problems in virtual agent design, robotics, genomics, neuroimaging, computer vision, and industrial automation. In this paper, the most relevant advances from the last few years in Artificial Intelligence (AI) and several applications to neuroscience, neuroimaging, computer vision, and robotics are presented, reviewed and discussed. In this way, we summarize the state-of-the-art in AI methods, models and applications within a collection of works presented at the 9 International Conference on the Interplay between Natural and Artificial Computation (IWINAC). The works presented in this paper are excellent examples of new scientific discoveries made in laboratories that have successfully transitioned to real-life applications.

Published
2023

32. Computational approaches to Explainable Artificial Intelligence:Advances in theory, applications and trends

Author

Górriz, J. M., Álvarez-Illán, I., Álvarez-Marquina, A., Arco, J. E., Atzmueller, M., Ballarini, F., Barakova, E., Bologna, G., Bonomini, P., Castellanos-Dominguez, G., Castillo-Barnes, D., Cho, S. B., Contreras, R., Cuadra, J. M., Domínguez, E., Domínguez-Mateos, F., Duro, R. J., Elizondo, D., Fernández-Caballero, A., Fernandez-Jover, E., Formoso, M. A., Gallego-Molina, N. J., Gamazo, J., González, J. García, Garcia-Rodriguez, J., Garre, C., Garrigós, J., Gómez-Rodellar, A., Gómez-Vilda, P., Graña, M., Guerrero-Rodriguez, B., Hendrikse, S. C.F., Jimenez-Mesa, C., Jodra-Chuan, M., Julian, V., Kotz, G., Kutt, K., Leming, M., de Lope, J., Macas, B., Marrero-Aguiar, V., Martinez, J. J., Martinez-Murcia, F. J., Martínez-Tomás, R., Mekyska, J., Nalepa, G. J., Novais, P., Orellana, D., Ortiz, A., Palacios-Alonso, D., Palma, J., Pereira, A., Pinacho-Davidson, P., Pinninghoff, M. A., Ponticorvo, M., Psarrou, A., Ramírez, J., Rincón, M., Rodellar-Biarge, V., Rodríguez-Rodríguez, I., Roelofsma, P. H.M.P., Santos, J., Salas-Gonzalez, D., Salcedo-Lagos, P., Segovia, F., Shoeibi, A., Silva, M., Simic, D., Suckling, J., Treur, J., Tsanas, A., Varela, R., Wang, S. H., Wang, W., Zhang, Y. D., Zhu, H., Zhu, Z., Ferrández-Vicente, J. M., Górriz, J. M., Álvarez-Illán, I., Álvarez-Marquina, A., Arco, J. E., Atzmueller, M., Ballarini, F., Barakova, E., Bologna, G., Bonomini, P., Castellanos-Dominguez, G., Castillo-Barnes, D., Cho, S. B., Contreras, R., Cuadra, J. M., Domínguez, E., Domínguez-Mateos, F., Duro, R. J., Elizondo, D., Fernández-Caballero, A., Fernandez-Jover, E., Formoso, M. A., Gallego-Molina, N. J., Gamazo, J., González, J. García, Garcia-Rodriguez, J., Garre, C., Garrigós, J., Gómez-Rodellar, A., Gómez-Vilda, P., Graña, M., Guerrero-Rodriguez, B., Hendrikse, S. C.F., Jimenez-Mesa, C., Jodra-Chuan, M., Julian, V., Kotz, G., Kutt, K., Leming, M., de Lope, J., Macas, B., Marrero-Aguiar, V., Martinez, J. J., Martinez-Murcia, F. J., Martínez-Tomás, R., Mekyska, J., Nalepa, G. J., Novais, P., Orellana, D., Ortiz, A., Palacios-Alonso, D., Palma, J., Pereira, A., Pinacho-Davidson, P., Pinninghoff, M. A., Ponticorvo, M., Psarrou, A., Ramírez, J., Rincón, M., Rodellar-Biarge, V., Rodríguez-Rodríguez, I., Roelofsma, P. H.M.P., Santos, J., Salas-Gonzalez, D., Salcedo-Lagos, P., Segovia, F., Shoeibi, A., Silva, M., Simic, D., Suckling, J., Treur, J., Tsanas, A., Varela, R., Wang, S. H., Wang, W., Zhang, Y. D., Zhu, H., Zhu, Z., and Ferrández-Vicente, J. M.

Abstract

Deep Learning (DL), a groundbreaking branch of Machine Learning (ML), has emerged as a driving force in both theoretical and applied Artificial Intelligence (AI). DL algorithms, rooted in complex and non-linear artificial neural systems, excel at extracting high-level features from data. DL has demonstrated human-level performance in real-world tasks, including clinical diagnostics, and has unlocked solutions to previously intractable problems in virtual agent design, robotics, genomics, neuroimaging, computer vision, and industrial automation. In this paper, the most relevant advances from the last few years in Artificial Intelligence (AI) and several applications to neuroscience, neuroimaging, computer vision, and robotics are presented, reviewed and discussed. In this way, we summarize the state-of-the-art in AI methods, models and applications within a collection of works presented at the 9th International Conference on the Interplay between Natural and Artificial Computation (IWINAC). The works presented in this paper are excellent examples of new scientific discoveries made in laboratories that have successfully transitioned to real-life applications.

Published
2023

34. Computational Approaches to Explainable Artificial Intelligence: Advances Intheory, Applications and Trends

Author

Górriz, Juan Manuel, primary, Álvarez-Illán, I., additional, Álvarez-Marquina, A., additional, Arcoa, J.E., additional, Atzmueller, M., additional, Ballarini, F., additional, Barakova, E., additional, Bologna, G., additional, Bonomini, P., additional, Castellanos-Dominguez, G., additional, Castillo-Barnes, D., additional, Cho, S.B., additional, Contreras, R., additional, Cuadra, J.M., additional, Domínguez, E., additional, Domínguez-Mateos, F., additional, Duro, R.J., additional, Elizondo, D., additional, Fernández-Caballero, A., additional, Fernandez-Jover, E., additional, Formoso, M.A., additional, Gallego-Molina, N.J., additional, Gamazo, J., additional, González, J. García, additional, Garcia-Rodriguez, J., additional, Garre, C., additional, Garrigós, J., additional, Gómez-Rodellar, A., additional, Gómez-Vilda, P., additional, Graña, M., additional, Guerrero-Rodriguez, B., additional, Hendrikse, S. C. F., additional, Jimenez-Mesa, C., additional, Jodra-Chuan, M., additional, Julian, V., additional, Kotz, G., additional, Kutt, K., additional, Leming, M., additional, Lope, J. de, additional, Macas, B., additional, Marrero-Aguiar, V., additional, Martinez, J.J., additional, Martinez-Murcia, F.J., additional, Martínez-Tomás, R., additional, Mekyska, J., additional, Nalepa, G.J., additional, Novais, P., additional, Orellana, D., additional, Ortiz, A., additional, Palacios-Alonso, D., additional, Palma, J., additional, Pereira, A., additional, Pinacho-Davidson, P., additional, Pinninghof, M.A., additional, Ponticorvo, M., additional, Psarrou, A., additional, Ramírez, J., additional, Rincón, M., additional, Rodellar-Biarge, V., additional, Rodríguez-Rodríguez, I., additional, Roelofsma, P. H.M.P., additional, Santos, J., additional, Salas-Gonzalez, D., additional, Salcedo-Lagos, P., additional, Segovia, F., additional, Shoeibi, A., additional, Silva, M., additional, Simic, D., additional, Suckling, J., additional, Treur, J., additional, Tsanas, Athanasios, additional, Varela, R., additional, Wang, SH., additional, Wang, W., additional, Zhang, YD., additional, Zhu, H., additional, Zhu, Z., additional, and Ferrández-Vicente, J.M., additional

Published
2023
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38. Imputed genomes and haplotype-based analyses of the Picts of early medieval Scotland reveal fine-scale relatedness between Iron Age, early medieval and the modern people of the UK

Author

Morez, A., Britton, K., Noble, G., Günther, T., Götherström, A., Rodríguez-Varela, R., Kashuba, N., Martiniano, R., Talamo, S., Evans, N., Irish, J., Donald, C., Girdland-Flink, L., Marchini, J., Mesoudi, A., Olsson, H., Pescetelli, N., Sloman, S., Smaldino, P., and Stein, D.

Subjects
Cancer Research, Archaeology, Genetics, Arkeologi, Molecular Biology, Genetics (clinical), Ecology, Evolution, Behavior and Systematics
Abstract

There are longstanding questions about the origins and ancestry of the Picts of early medieval Scotland (ca. 300-900 CE), prompted in part by exotic medieval origin myths, their enigmatic symbols and inscriptions, and the meagre textual evidence. The Picts, first mentioned in the late 3(rd) century CE resisted the Romans and went on to form a powerful kingdom that ruled over a large territory in northern Britain. In the 9(th) and 10(th) centuries Gaelic language, culture and identity became dominant, transforming the Pictish realm into Alba, the precursor to the medieval kingdom of Scotland. To date, no comprehensive analysis of Pictish genomes has been published, and questions about their biological relationships to other cultural groups living in Britain remain unanswered. Here we present two high-quality Pictish genomes (2.4 and 16.5X coverage) from central and northern Scotland dated from the 5(th)-7(th) century which we impute and co-analyse with >8,300 previously published ancient and modern genomes. Using allele frequency and haplotype-based approaches, we can firmly place the genomes within the Iron Age gene pool in Britain and demonstrate regional biological affinity. We also demonstrate the presence of population structure within Pictish groups, with Orcadian Picts being genetically distinct from their mainland contemporaries. When investigating Identity-By-Descent (IBD) with present-day genomes, we observe broad affinities between the mainland Pictish genomes and the present-day people living in western Scotland, Wales, Northern Ireland and Northumbria, but less with the rest of England, the Orkney islands and eastern Scotland-where the political centres of Pictland were located. The pre-Viking Age Orcadian Picts evidence a high degree of IBD sharing across modern Scotland, Wales, Northern Ireland, and the Orkney islands, demonstrating substantial genetic continuity in Orkney for the last similar to 2,000 years. Analysis of mitochondrial DNA diversity at the Pictish cemetery of Lundin Links (n = 7) reveals absence of direct common female ancestors, with implications for broader social organisation. Overall, our study provides novel insights into the genetic affinities and population structure of the Picts and direct relationships between ancient and present-day groups of the UK. Author summary: We report two high-quality autosomal and eight mitochondrial genomes sequenced from individuals associated with the Pictish period of early medieval Scotland (ca. 300-900 CE). We demonstrate genetic affinities between the Pictish genomes and Iron Age people who lived in Britain, which supports current archaeological theories of a local origin. The autosomal genomes also allowed us to detect haplotype sharing between the Pictish genomes and present-day Europeans. Our results demonstrate a proportionally higher degree of haplotype sharing, and thus genetic affinity, between the Pictish genomes and individuals from western Scotland, Wales, Northern Ireland and Northumbria. We also detected genetic structure in Scotland during the Iron Age, likely driven by the combination of genetic drift and small population size, which we also detect in present-day Orcadians. Lastly, the seven mitochondrial DNA from the Lundin Links cemetery showed that these individuals had no direct maternal ancestors which could suggest exchanges of people, or at least females, between groups during the Pictish period, challenging older ideas that the Picts were a matrilineal society. Overall, our results show that high-quality ancient genomes combined with haplotype imputation are highly informative for obtaining novel insights to population structure and migration over the past 2,000 years.

Published
2023

43. Perceptions of Parenting, Emotional Self-Efficacy, and Anxiety in Youth: Test of a Mediational Model

Author

Niditch, Laura A. and Varela, R. Enrique

Abstract

Background: Though associations between parenting styles marked by control (e.g., prevention of autonomous experiences) or rejection (e.g., criticism, arbitrary blame, and withholding of warmth) and youth anxiety have been established in the literature, few studies have examined cognitive mediators purported to explain these associations. Objective: The present study explored relations among perceptions of maternal and paternal parenting, emotional self-efficacy (i.e., perceived control over negative emotion), and anxiety in adolescents and tested a mediational model in which emotional self-efficacy explains the relation between negative parenting styles and youth anxiety. Methods: One hundred and twenty-four non-referred adolescents aged 12-18 completed questionnaires assessing study variables in school settings. Results: Emotional self-efficacy and maternal rejection predicted anxiety, maternal control was a marginally significant predictor of anxiety, and paternal rejection and control were not associated with anxiety. Maternal rejection, but not paternal rejection or control by either parent, predicted emotional self-efficacy, and emotional self-efficacy mediated the relation between maternal rejection and anxiety. Conclusions: Results offer support for a commonly cited theoretical pathway from maternal rejection to youth anxiety by teaching that positive emotional outcomes are rare and outside of the child's control. Support was not found for a similarly theorized pathway from maternal control to youth anxiety through emotional self-efficacy. Findings point to a greater relation between youth anxiety and perceived negative parenting by mothers relative to fathers.

Published
2012
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44. Exploring the Association between Cognitive Functioning and Anxiety in Children with Autism Spectrum Disorders: The Role of Social Understanding and Aggression

Author

Niditch, Laura A., Varela, R. Enrique, Kamps, Jodi L., and Hill, Trenesha

Abstract

This study examined relations between anxiety, aggression, social understanding, IQ, and diagnosis in a sample of 231 children (ages 2-9) diagnosed with Autism Spectrum Disorders (ASDs; Autistic Disorder, Asperger's Disorder, Pervasive Developmental Disorder Not Otherwise Specified) in a hospital setting. Children were administered tests of IQ, and parents completed measures of remaining variables. ASD diagnosis was associated with level of anxiety, and level of IQ explained this relation. IQ was significantly and positively associated with anxiety. Tests of a developmental model to explain the relation between IQ and anxiety showed that social understanding and aggression mediated the relation for toddlers. For preschool- and early elementary school-aged children, respectively, three-way interactions between IQ, social understanding, and aggression predicted anxiety, and graphs of the interactions suggest that the association between IQ and anxiety is increasingly driven by either aggression or social understanding over the course of childhood. (Contains 3 tables and 2 figures.)

Published
2012
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45. Age and Adaptive Functioning in Children and Adolescents with ASD: The Effects of Intellectual Functioning and ASD Symptom Severity

Author

Hill, Trenesha L., Gray, Sarah A. O., Kamps, Jodi L., and Enrique Varela, R.

Subjects
Intelligence (Psychology) -- Analysis, Pervasive developmental disorders -- Care and treatment -- Research, Health
Abstract

The present study examined the moderating effects of intellectual functioning and ASD symptom severity on the relation between age and adaptive functioning in 220 youth with autism spectrum disorder (ASD). Regression analysis indicated that intellectual functioning and ASD symptom severity moderated the relation between age and adaptive functioning. For younger children with lower intellectual functioning, higher ASD symptom severity was associated with better adaptive functioning than that of those with lower ASD symptom severity. Similarly, for older children with higher intellectual functioning, higher ASD symptom severity was associated with better adaptive functioning than that of those with lower ASD symptom severity. Analyses by subscales suggest that this pattern is driven by the Conceptual subscale. Clinical and research implications are discussed., Author(s): Trenesha L. Hill[sup.1] , Sarah A. O. Gray[sup.1] , Jodi L. Kamps[sup.2] , R. Enrique Varela[sup.3] Author Affiliations: (1) Department of Psychology, Tulane University, 2007 Percival Stern Hall, 6400 [...]

Published
2015
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46. Correlates of Long-Term Posttraumatic Stress Symptoms in Children Following Hurricane Katrina

Author

Moore, Kathryn W. and Varela, R. Enrique

Abstract

The present study examined the roles of loss and disruption, major life events, and social support in the relationship between exposure and PTSD symptoms in a group of children 33 months after Hurricane Katrina. One hundred fifty-six 4th, 5th, and 6th graders were surveyed in the New Orleans area. Results indicated that 46% of the children reported moderate to very severe levels of PTSD symptoms. Lower levels of classmate support and more negative life events after the hurricane were uniquely related to PTSD symptoms. Analyses did not reveal any moderating relationships among the variables. The results of this study have implications for the prevention and treatment of PTSD symptoms long after exposure to trauma.

Published
2010
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48. The Influence of Culture on Anxiety in Latino Youth: A Review

Author

Varela, R. Enrique and Hensley-Maloney, Lauren

Abstract

This article reviews the literature on how culture influences anxiety in Latino youth. First, a review of cross-cultural variations in prevalence and measurement is presented. Then, the article focuses on how culture impacts the meaning and expression of anxiety. Specifically, we discuss the meaning and expression of anxiety, the impact of culture on anxiety at a societal level and through its effect on family and cognitive processes, and the influence of immigration and acculturation on anxiety. Finally, we propose recommendations on how to advance the literature in this area building on existing knowledge.

Published
2009
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49. The Influence of Hurricane Exposure and Anxiety Sensitivity on Panic Symptoms

Author

Hensley-Maloney, Lauren and Varela, R. Enrique

Abstract

Trauma exposure has been associated with panic symptoms in adult samples, but little is known about the relationship between trauma and panic in children. Anxiety sensitivity (AS), or the fear of anxiety-related bodily sensations, may help explain the relationship between trauma and panic. To examine relationships among trauma, anxiety sensitivity, and panic symptoms, data were collected from youth in the New Orleans area 5-8 months after Hurricane Katrina (N = 302) and again 17-18 months after the hurricane (N = 110). At time one (T1), AS predicted panic symptoms beyond hurricane exposure. At time two (T2), AS measured at time two (T2) predicted panic symptoms beyond AS measured at T1. Clinical implications of the present findings are discussed.

Published
2009
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50. PTSD Symptoms and Somatic Complaints Following Hurricane Katrina: The Roles of Trait Anxiety and Anxiety Sensitivity

Author

Hensley, Lauren and Varela, R. Enrique

Abstract

This study examined the relationships between trait anxiety and anxiety sensitivity and the outcome variables posttraumatic stress disorder (PTSD) symptoms and somatic complaints following a major hurricane. Sixth and seventh graders in the New Orleans area (N=302) were surveyed 5 to 8 months following Hurricane Katrina. As expected, hurricane exposure was a significant predictor of PTSD symptoms and somatic symptoms. Also as hypothesized, certain factors of anxiety sensitivity interacted with trait anxiety to predict PTSD symptoms and somatic symptoms. Clinical implications of potential linkages among trait anxiety, dimensions of anxiety sensitivity and PTSD, and somatic symptoms are discussed. (Contains 4 tables and 2 figures.)

Published
2008
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