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Your search keyword '"Vardhan, Mridula"' showing total 7 results
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7 results on '"Vardhan, Mridula"'

1. The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL

Author

Aykut, Berk, Pushalkar, Smruti, Chen, Ruonan, Li, Qianhao, Abengozar, Raquel, Kim, Jacqueline I., Shadaloey, Sorin A., Wu, Dongling, Preiss, Pamela, Verma, Narendra, Guo, Yuqi, Saxena, Anjana, Vardhan, Mridula, Diskin, Brian, Wang, Wei, Leinwand, Joshua, Kurz, Emma, Kochen Rossi, Juan A., Hundeyin, Mautin, Zambrinis, Constantinos, Li, Xin, Saxena, Deepak, and Miller, George

Published
2019
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2. Intrahepatic microbes govern liver immunity by programming NKT cells

Author

Leinwand, Joshua C., Paul, Bidisha, Chen, Ruonan, Xu, Fangxi, Sierra, Maria A., Paluru, Madan M., Nanduri, Sumant, Alcantara, Carolina G., Shadaloey, Sorin A.A., Yang, Fan, Adam, Salma A., Li, Qianhao, Bandel, Michelle, Gakhal, Inderdeep, Appiah, Lara, Guo, Yuqi, Vardhan, Mridula, Flaminio, Zia, Grodman, Emilie R., Mermelstein, Ari, Wang, Wei, Diskin, Brian, Aykut, Berk, Khan, Mohammad, Werba, Gregor, Pushalkar, Smruti, McKinstry, Mia, Kluger, Zachary, Park, Jaimie J., Hsieh, Brandon, Dancel-Manning, Kristen, Liang, Feng-Xia, Park, James S., Saxena, Anjana, Li, Xin, Theise, Neil D., Saxena, Deepak, and Miller, George

Subjects
Microbiota (Symbiotic organisms) -- Health aspects -- Physiological aspects, Host-bacteria relationships -- Research, Immunity -- Research, Killer cells -- Health aspects -- Physiological aspects, Cellular control mechanisms -- Research, Health care industry
Abstract

The gut microbiome shapes local and systemic immunity. The liver is presumed to be a protected sterile site. As such, a hepatic microbiome has not been examined. Here, we showed a liver microbiome in mice and humans that is distinct from that of the gut and is enriched in Proteobacteria. It undergoes dynamic alterations with age and is influenced by the environment and host physiology. Fecal microbial transfer experiments revealed that the liver microbiome is populated from the gut in a highly selective manner. Hepatic immunity is dependent on the microbiome, specifically the bacteroidetes species. Targeting bacteroidetes with oral antibiotics reduced hepatic immune cells by approximately 90%, prevented antigen-presenting cell (APC) maturation, and mitigated adaptive immunity. Mechanistically, our findings are consistent with presentation of bacteroidetes-derived glycosphingolipids to NKT cells promoting CCL5 signaling, which drives hepatic leukocyte expansion and activation, among other possible host-microbe interactions. Collectively, we reveal a microbial/glycosphingolipid/NKT/CCL5 axis that underlies hepatic immunity., Introduction Gut microbiota represent the most abundant and diverse collection of commensal organisms in the body (1). The intestinal microbiome plays a fundamental role in shaping the host immune system [...]

Published
2022
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4. Electronic Cigarette Use Promotes a Unique Periodontal Microbiome

Author

Thomas, Scott C., primary, Xu, Fangxi, additional, Pushalkar, Smruti, additional, Lin, Ziyan, additional, Thakor, Nirali, additional, Vardhan, Mridula, additional, Flaminio, Zia, additional, Khodadadi-Jamayran, Alireza, additional, Vasconcelos, Rebeca, additional, Akapo, Adenike, additional, Queiroz, Erica, additional, Bederoff, Maria, additional, Janal, Malvin N., additional, Guo, Yuqi, additional, Aguallo, Deanna, additional, Gordon, Terry, additional, Corby, Patricia M., additional, Kamer, Angela R., additional, Li, Xin, additional, and Saxena, Deepak, additional

Published
2022
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5. Electronic cigarette use enriches periodontal pathogens

Author

Xu, Fangxi, primary, Pushalkar, Smruti, additional, Lin, Ziyan, additional, Thomas, Scott C., additional, Persaud, Julia Kishanie, additional, Sierra, Maria A, additional, Vardhan, Mridula, additional, Vasconcelos, Rebeca, additional, Akapo, Adenike, additional, Guo, Yuqi, additional, Gordon, Terry, additional, Corby, Patricia M, additional, Kamer, Angela R., additional, Li, Xin, additional, and Saxena, Deepak, additional

Published
2022
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