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28 results on '"Vanspauwen, Vanessa"'

1. Data from Coactivated Platelet-Derived Growth Factor Receptor α and Epidermal Growth Factor Receptor Are Potential Therapeutic Targets in Intimal Sarcoma

Author

Dewaele, Barbara, primary, Floris, Giuseppe, primary, Finalet-Ferreiro, Julio, primary, Fletcher, Christopher D., primary, Coindre, Jean-Michel, primary, Guillou, Louis, primary, Hogendoorn, Pancras C.W., primary, Wozniak, Agnieszka, primary, Vanspauwen, Vanessa, primary, Schöffski, Patrick, primary, Marynen, Peter, primary, Vandenberghe, Peter, primary, Sciot, Raf, primary, and Debiec-Rychter, Maria, primary

Published
2023
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2. Supplementary Table 2 from Coactivated Platelet-Derived Growth Factor Receptor α and Epidermal Growth Factor Receptor Are Potential Therapeutic Targets in Intimal Sarcoma

Author

Dewaele, Barbara, primary, Floris, Giuseppe, primary, Finalet-Ferreiro, Julio, primary, Fletcher, Christopher D., primary, Coindre, Jean-Michel, primary, Guillou, Louis, primary, Hogendoorn, Pancras C.W., primary, Wozniak, Agnieszka, primary, Vanspauwen, Vanessa, primary, Schöffski, Patrick, primary, Marynen, Peter, primary, Vandenberghe, Peter, primary, Sciot, Raf, primary, and Debiec-Rychter, Maria, primary

Published
2023
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3. Supplementary Figure 1 from Coactivated Platelet-Derived Growth Factor Receptor α and Epidermal Growth Factor Receptor Are Potential Therapeutic Targets in Intimal Sarcoma

Author

Dewaele, Barbara, primary, Floris, Giuseppe, primary, Finalet-Ferreiro, Julio, primary, Fletcher, Christopher D., primary, Coindre, Jean-Michel, primary, Guillou, Louis, primary, Hogendoorn, Pancras C.W., primary, Wozniak, Agnieszka, primary, Vanspauwen, Vanessa, primary, Schöffski, Patrick, primary, Marynen, Peter, primary, Vandenberghe, Peter, primary, Sciot, Raf, primary, and Debiec-Rychter, Maria, primary

Published
2023
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4. Supplementary Table 1 from Coactivated Platelet-Derived Growth Factor Receptor α and Epidermal Growth Factor Receptor Are Potential Therapeutic Targets in Intimal Sarcoma

Author

Dewaele, Barbara, primary, Floris, Giuseppe, primary, Finalet-Ferreiro, Julio, primary, Fletcher, Christopher D., primary, Coindre, Jean-Michel, primary, Guillou, Louis, primary, Hogendoorn, Pancras C.W., primary, Wozniak, Agnieszka, primary, Vanspauwen, Vanessa, primary, Schöffski, Patrick, primary, Marynen, Peter, primary, Vandenberghe, Peter, primary, Sciot, Raf, primary, and Debiec-Rychter, Maria, primary

Published
2023
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5. Supplementary Figure Legends 1-2 from Coactivated Platelet-Derived Growth Factor Receptor α and Epidermal Growth Factor Receptor Are Potential Therapeutic Targets in Intimal Sarcoma

Author

Dewaele, Barbara, primary, Floris, Giuseppe, primary, Finalet-Ferreiro, Julio, primary, Fletcher, Christopher D., primary, Coindre, Jean-Michel, primary, Guillou, Louis, primary, Hogendoorn, Pancras C.W., primary, Wozniak, Agnieszka, primary, Vanspauwen, Vanessa, primary, Schöffski, Patrick, primary, Marynen, Peter, primary, Vandenberghe, Peter, primary, Sciot, Raf, primary, and Debiec-Rychter, Maria, primary

Published
2023
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6. Supplementary Table 3 from Coactivated Platelet-Derived Growth Factor Receptor α and Epidermal Growth Factor Receptor Are Potential Therapeutic Targets in Intimal Sarcoma

Author

Dewaele, Barbara, primary, Floris, Giuseppe, primary, Finalet-Ferreiro, Julio, primary, Fletcher, Christopher D., primary, Coindre, Jean-Michel, primary, Guillou, Louis, primary, Hogendoorn, Pancras C.W., primary, Wozniak, Agnieszka, primary, Vanspauwen, Vanessa, primary, Schöffski, Patrick, primary, Marynen, Peter, primary, Vandenberghe, Peter, primary, Sciot, Raf, primary, and Debiec-Rychter, Maria, primary

Published
2023
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7. Supplementary Figure 2 from Coactivated Platelet-Derived Growth Factor Receptor α and Epidermal Growth Factor Receptor Are Potential Therapeutic Targets in Intimal Sarcoma

Author

Dewaele, Barbara, primary, Floris, Giuseppe, primary, Finalet-Ferreiro, Julio, primary, Fletcher, Christopher D., primary, Coindre, Jean-Michel, primary, Guillou, Louis, primary, Hogendoorn, Pancras C.W., primary, Wozniak, Agnieszka, primary, Vanspauwen, Vanessa, primary, Schöffski, Patrick, primary, Marynen, Peter, primary, Vandenberghe, Peter, primary, Sciot, Raf, primary, and Debiec-Rychter, Maria, primary

Published
2023
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13. A novel EWS-CREB3L3 gene fusion in a mesenteric sclerosing epithelioid fibrosarcoma

Author

UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'anatomie pathologique, UCL - (SLuc) Service d'hématologie et d'oncologie pédiatrique, Dewaele, Barbara, Libbrecht, Louis, Levy, Gabriel, Brichard, Bénédicte, Vanspauwen, Vanessa, Sciot, Raf, Debiec-Rychter, Maria, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'anatomie pathologique, UCL - (SLuc) Service d'hématologie et d'oncologie pédiatrique, Dewaele, Barbara, Libbrecht, Louis, Levy, Gabriel, Brichard, Bénédicte, Vanspauwen, Vanessa, Sciot, Raf, and Debiec-Rychter, Maria

Abstract

Sclerosing epithelioid fibrosarcoma (SEF) is a rare, malignant fibroblastic neoplasm, morphologically composed of cords, nests or sheets of monotonous epithelioid cells within a collagenous matrix. It has been recently characterized by recurrent pathogenic EWS-CREB3L1/2 or FUS-CREB3L2 fusions and common MUC4 protein expression by immunohistochemistry. Typically SEF occur in middle-aged adults and rarely have been reported within the abdominal cavity. Here we report an 18-year-old man with intraabdominal tumor and multiple disseminated liver metastases, presenting pure SEF histologic and immunophenotypic features. Fluorescence in situ hybridization analysis showed unbalanced rearrangement of Ewing sarcoma breakpoint region 1 (EWSR1) gene. Genomic profiling by array CGH, followed by RT-PCR and sequencing analysis, revealed a previously not reported EWSR1 translocation partner, cAMP-responsive element-binding protein 3-like 3 (CREB3L3). The novel EWSR1-CREB3L3 fusion further extends the range of fusion types involving EWSR1 that are characteristic for SEF

Published
2017

15. Macrophage infiltration and genetic landscape of undifferentiated uterine sarcomas

Author

Przybyl, Joanna, primary, Kowalewska, Magdalena, additional, Quattrone, Anna, additional, Dewaele, Barbara, additional, Vanspauwen, Vanessa, additional, Varma, Sushama, additional, Vennam, Sujay, additional, Newman, Aaron M., additional, Swierniak, Michal, additional, Bakuła-Zalewska, Elwira, additional, Siedlecki, Janusz A., additional, Bidzinski, Mariusz, additional, Cools, Jan, additional, van de Rijn, Matt, additional, and Debiec-Rychter, Maria, additional

Published
2017
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16. Abstract 3182: Tumor associated macrophages in undifferentiated uterine sarcoma: association with angiogenesis and therapeutic implications

Author

Przybyl, Joanna, primary, Kowalewska, Magdalena, additional, Quattrone, Anna, additional, Dewaele, Barbara, additional, Vanspauwen, Vanessa, additional, Varma, Sushama, additional, Sweeney, Robert T., additional, Swierniak, Michal, additional, Bakula-Zalewska, Elwira, additional, Siedlecki, Janusz A., additional, Bidzinski, Mariusz, additional, Cools, Jan, additional, van de Rijn, Matt, additional, and Debiec-Rychter, Maria, additional

Published
2016
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17. Promoting role of cholecystokinin 2 receptor (CCK2R) in gastrointestinal stromal tumours pathogenesis

Author

Quattrone, Anna, Dewaele, Barbara, Wozniak, Agnieszka, Bauters, Marijke, Vanspauwen, Vanessa, Floris, Guiseppe, Schöffski, Patrick, Chibon, Frederic, Coindre, Jean-Michel, Sciot, Raf, and Debiec-Rychter, Maria

Subjects
neoplasms, digestive system diseases
Abstract

The cholecystokinin 2 receptor (CCK2R/CCKBR) is expressed in gastrointestinal stromal tumours (GIST). We sought to investigate the role of CCK2R in GIST pathogenesis. Molecular characterization of CCK2R was performed on a heterogeneous cohort of 50 GIST. In addition, CCK2R expression was evaluated by immunohistochemistry (IHC) using tissue microarray (TMA) containing 292 GIST, two cases of hyperplasia of interstitial Cajal's cells (ICC) and six gastric microscopic GIST. Mono-allelic loss of the CCK2R/11p15 allele was identified in 13.7% of GIST, having no impact on the level of CCK2R transcript expression. No CCK2R mutations were found. The CCK2Ri4sv, CCK2R splice variant with retention of intron 4, was detected in 6 out of 20 analysed tumours. Wild-type CCK2R transcripts were commonly expressed (57.1% of cases) and this expression highly correlated with gastric primary site of GIST (p

Published
2012

19. Abstract 4698: Gene expression profiling distinguishes between endometrial stromal tumors subtypes

Author

Przybyl, Joanna, primary, Kowalewska, Magdalena, additional, Quattrone, Anna, additional, Dewaele, Barbara, additional, Vanspauwen, Vanessa, additional, Finalet-Ferreiro, Julio, additional, Swierniak, Michal, additional, Bakula-Zalewska, Elwira, additional, Siedlecki, Janusz A., additional, Bidzinski, Mariusz, additional, Cools, Jan, additional, and Debiec-Rychter, Maria, additional

Published
2014
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21. Identification of a novel, recurrent MBTD1‐CXorf67 fusion in low‐grade endometrial stromal sarcoma

Author

Dewaele, Barbara, primary, Przybyl, Joanna, additional, Quattrone, Anna, additional, Finalet Ferreiro, Julio, additional, Vanspauwen, Vanessa, additional, Geerdens, Ellen, additional, Gianfelici, Valentina, additional, Kalender, Zeynep, additional, Wozniak, Agnieszka, additional, Moerman, Philippe, additional, Sciot, Raf, additional, Croce, Sabrina, additional, Amant, Frederic, additional, Vandenberghe, Peter, additional, Cools, Jan, additional, and Debiec‐Rychter, Maria, additional

Published
2013
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25. Frequent activation of EGFR in advanced chordomas

Author

Dewaele, Barbara, primary, Maggiani, Francesca, additional, Floris, Giuseppe, additional, Ampe, Michèle, additional, Vanspauwen, Vanessa, additional, Wozniak, Agnieszka, additional, Debiec-Rychter, Maria, additional, and Sciot, Raf, additional

Published
2011
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26. Coactivated Platelet-Derived Growth Factor Receptor α and Epidermal Growth Factor Receptor Are Potential Therapeutic Targets in Intimal Sarcoma

Author

Dewaele, Barbara, primary, Floris, Giuseppe, additional, Finalet-Ferreiro, Julio, additional, Fletcher, Christopher D., additional, Coindre, Jean-Michel, additional, Guillou, Louis, additional, Hogendoorn, Pancras C.W., additional, Wozniak, Agnieszka, additional, Vanspauwen, Vanessa, additional, Schöffski, Patrick, additional, Marynen, Peter, additional, Vandenberghe, Peter, additional, Sciot, Raf, additional, and Debiec-Rychter, Maria, additional

Published
2010
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28. Coactivated platelet-derived growth factor receptor {alpha} and epidermal growth factor receptor are potential therapeutic targets in intimal sarcoma.

Author

Dewaele B, Floris G, Finalet-Ferreiro J, Fletcher CD, Coindre JM, Guillou L, Hogendoorn PC, Wozniak A, Vanspauwen V, Schöffski P, Marynen P, Vandenberghe P, Sciot R, and Debiec-Rychter M

Subjects
Adult, Aged, Benzamides, Comparative Genomic Hybridization, Dasatinib, ErbB Receptors antagonists & inhibitors, ErbB Receptors genetics, Female, Humans, Imatinib Mesylate, In Situ Hybridization, Fluorescence, Karyotyping, Male, Middle Aged, Phosphorylation, Piperazines pharmacology, Protein Kinase Inhibitors pharmacology, Pyrimidines pharmacology, Receptor, Platelet-Derived Growth Factor alpha antagonists & inhibitors, Receptor, Platelet-Derived Growth Factor alpha genetics, Sarcoma drug therapy, Sarcoma genetics, Sarcoma pathology, Thiazoles pharmacology, Tunica Intima enzymology, Tunica Intima pathology, Vascular Neoplasms drug therapy, Vascular Neoplasms genetics, Vascular Neoplasms pathology, ErbB Receptors metabolism, Receptor, Platelet-Derived Growth Factor alpha metabolism, Sarcoma enzymology, Vascular Neoplasms enzymology
Abstract

Intimal sarcoma (IS) is a rare, malignant, and aggressive tumor that shows a relentless course with a concomitant low survival rate and for which no effective treatment is available. In this study, 21 cases of large arterial blood vessel IS were analyzed by immunohistochemistry and fluorescence in situ hybridization and selectively by karyotyping, array comparative genomic hybridization, sequencing, phospho-kinase antibody arrays, and Western immunoblotting in search for novel diagnostic markers and potential molecular therapeutic targets. Ex vivo immunoassays were applied to test the sensitivity of IS primary tumor cells to the receptor tyrosine kinase (RTK) inhibitors imatinib and dasatinib. We showed that amplification of platelet-derived growth factor receptor α (PDGFRA) is a common finding in IS, which should be considered as a molecular hallmark of this entity. This amplification is consistently associated with PDGFRA activation. Furthermore, the tumors reveal persistent activation of the epidermal growth factor receptor (EGFR), concurrent to PDGFRA activation. Activated PDGFRA and EGFR frequently coexist with amplification and overexpression of the MDM2 oncogene. Ex vivo immunoassays on primary IS cells from one case showed the potency of dasatinib to inhibit PDGFRA and downstream signaling pathways. Our findings provide a rationale for investigating therapies that target PDGFRA, EGFR, or MDM2 in IS. Given the clonal heterogeneity of this tumor type and the potential cross-talk between the PDGFRA and EGFR signaling pathways, targeting multiple RTKs and aberrant downstream effectors might be required to improve the therapeutic outcome for patients with this disease., (©2010 AACR.)

Published
2010
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