1. Fortified balanced energy-protein supplementation during pregnancy and lactation and infant growth in rural Burkina Faso: A 2 x 2 factorial individually randomized controlled trial
- Author
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Argaw, Alemayehu, de Kok, Brenda, Toe, Laeticia Celine, Hanley-Cook, Giles, Dailey-Chwalibóg, Trenton, Ouédraogo, Moctar, Compaoré, Anderson, Vanslambrouck, Katrien, Ganaba, Rasmané, Kolsteren, Patrick, Lachat, Carl, and Huybregts, Lieven
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Rural population -- Health aspects -- Food and nutrition ,Infants -- Food and nutrition -- Health aspects -- Growth ,Dietary supplements -- Usage -- Health aspects ,Pregnant women -- Health aspects -- Food and nutrition ,Malnutrition in children -- Prevention -- Risk factors ,Company growth ,Biological sciences - Abstract
Background Optimal nutrition is crucial during the critical period of the first 1,000 days from conception to 2 years after birth. Prenatal and postnatal supplementation of mothers with multimicronutrient-fortified balanced energy-protein (BEP) supplements is a potential nutritional intervention. However, evidence on the long-term effects of BEP supplementation on child growth is inconsistent. We evaluated the efficacy of daily fortified BEP supplementation during pregnancy and lactation on infant growth in rural Burkina Faso. Methods and findings A 2 x 2 factorial individually randomized controlled trial (MISAME-III) was implemented in 6 health center catchment areas in Houndé district under the Hauts-Bassins region. From October 2019 to December 2020, 1,897 pregnant women aged 15 to 40 years with gestational age Conclusions This study provides evidence that the benefits obtained from prenatal BEP supplementation on size at birth are sustained during infancy in terms of linear growth. Maternal BEP supplementation during lactation may lead to a slightly better linear growth towards the second half of infancy. These findings suggest that BEP supplementation during pregnancy can contribute to the efforts to reduce the high burden of child growth faltering in low- and middle-income countries. Trial registration ClinicalTrials.gov: NCT03533712., Author(s): Alemayehu Argaw 1,2, Brenda de Kok 1, Laeticia Celine Toe 1,3, Giles Hanley-Cook 1, Trenton Dailey-Chwalibóg 1, Moctar Ouédraogo 4, Anderson Compaoré 4, Katrien Vanslambrouck 1, Rasmané Ganaba 4, [...]
- Published
- 2023
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