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5 results on '"Vanroyen, N"'

1. Abstracts of Original Contributions Cardiovascular Molecular Imaging Symposium May 3–4, 2004 Bethesda, Maryland

Author

Lahoutte, T, Vanhove, C, Caveliers, V, Defrise, M, Everaert, H, Bossuyt, A, Franken, P. R., Schäfers, K. P., Kriens, M., Barnard, C., Schober, O., Schäfers, M., Kopka, K, Wagner, S, Law, MP, Riemann, B, Pike, VW, Herrero, P, Dence, CS, Kisrieva-Ware, Z, Eisenbeis, P, Welch, MJ, Gropler, RJ, Bucerius, J, Joe, AY, Schmaliohann, J, Gündisch, D, Reinhardt, MJ, Biersack, H-J, Wüllner, U, Ranney, DF, Peshock, RM, McDonald, GG, Slomka, PJ, deKemp, RA, Beanlands, RSB, Nishina, H, Abidov, A, Berman, DS, Germano, G, Riou, LM, Goode, AR, Hatada, K, Ruiz, M, Lima, R, Harris, TD, Beller, GA, Glover, DK, Kim, H, Miceli, MH, Delbeke, D, Bhargava, P, Jackson, LB Jones, Walker, RC, Anaissie, E, Alavi, A, Hanrahan, SM, Janabi, M, Taylor, SE, Rychak, JJ, Klibanov, AL, Leppanen, A, Cummings, RD, Ley, K, Rychak, JJ, Klibanov, AL, Hossack, J, Dence, CS, Herrero, P, Gropler, RJ, Welch, MJ, Veress, AI, Feng, B, Yang, Y, Weiss, JA, Huesman, RH, Gullberg, GT, Sharp, TL, Herrero, P, Englebach, JA, Fettig, NM, Gropler, RJ, Welch, MJ, Dobrucki, LW, Hua, J, Bourke, BN, Sadeghi, MM, Cavaliere, P, Mendizabal, M, VanRoyen, N, Buschmann, IR, Sinusas, AJ, Sadeghi, MM, Zhang, J, Fassaei, HR, Krassilnikova, S, Esmailzadeh, L, Gharaei, AA, Kooshkabadi, A, Edwards, DS, Harris, TD, Yalamanchili, P, Sinusas, AJ, Zaret, BL, Bender, JR, Epstein, FH, Gilson, WD, Sureau, FC, Yang, Z, French, BA, Lewis, S, Lu, XE, Tom, EM, Felix, MM, Gretton, JE, Varghese, RP, Wagner, WR, and Villanueva, FS

Published
2004
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2. Transplantation in patients with SCID: mismatched related stem cells or unrelated cord blood?

Author

Fernandes, Jf, Rocha, V, Labopin, M, Neven, B, Moshous, D, Gennery, Ar, Friedrich, W, Porta, F, Diaz de Heredia, C, Wall, D, Bertrand, Y, Veys, P, Slatter, M, Schulz, A, Chan, Kw, Grimley, M, Ayas, M, Gungor, T, Ebell, W, Bonfim, C, Kalwak, K, Taupin, P, Blanche, S, Gaspar, Hb, Landais, P, Fischer, A, Gluckman, E, Cavazzana Calvo, M, Eurocord, Inborn Errors Working Party of European Group for Blood, Marrow Transplantation: Ahmed, A, Auiti, A, Biffi, A, Cant, A, Fasth, A, Gennery, A, Hassan, A, Lankester, A, O'Mera, A, Plabani, A, Rovelli, A, Salmon, A, Scarselli, A, Thrasher, A, Van Royen, A, Villa, A, Wawer, A, Wahadneh, A, Worth, A, Belohradsky, B, Wolska, B, Gaspar, B, Bonfirm, C, Booth, C, Klein, C, Messina, C, Peters, C, Steward, C, Lindemans, C, Schuetz, C, de Heredia Rubio CD, Bensoussan, D, Gleadow, D, Lilic, D, Gambineri, Eleonora, Smith, E, Aerts, F, Caracseghi, F, Roberts, G, Davies, G, Al Mousa, H, Jossanc, H, Ozsahim, H, Hirsch, I, Meyts, I, Tezcan, I, Mueller, I, Andresc, I, Boelens, J, Fernandes, J, Folloni, J, Keuhl, J, Reichenbach, J, Stary, J, Wachowiak, J, Xu Bayford, J, Cunha, Jm, Ehlert, J, Rao, K, Sykora, K, Andais, L, Brown, L, Dal Cortivo, L, Griffith, L, Notarangelo, L, Abinun, M, Albert, M, Bierings, M, Bouchet, M, Cavazzana, M, Hirschfield, M, Cowan, M, Hoenig, M, Loubser, M, Roncarolo, M, Sauer, M, Schneider, M, Verstegen, M, Schroeder, M, Essink, M, Yesilipek, M, Entz Werle, N, Mahlaoui, N, Schlautmann, N, Taylor, N, Vanroyen, N, Walffraat, N, Sanal, O, Amrolia, P, Bordigoni, P, De Coppi, P, Frange, P, Orchard, P, Sedlacek, P, Shaw, P, Stephensky, P, Bacchetta, R, Bredius, R, Formankova, R, Gale, R, Seger, R, Wynn, R, Corbacioglu, S, Ehl, S, Hacein Bey, S, Hambleton, S, Mohsen, S, Mueller, S, Pai, Sy, Espanol, T, Flood, T, Guengoer, T, Bordon, V, Ormoor, V, Pashano, V, Courteille, V, Czogala, W, Qasim, W, Camci, Y, and Nademi, Z.

Subjects
Male, medicine.medical_specialty, Transplantation Conditioning, medicine.medical_treatment, Immunology, Graft vs Host Disease, Kaplan-Meier Estimate, Cord Blood Stem Cell Transplantation, Hematopoietic stem cell transplantation, Biochemistry, Gastroenterology, SCID HSCT, Internal medicine, medicine, Humans, Proportional Hazards Models, Retrospective Studies, Preparative Regimen, Severe combined immunodeficiency, business.industry, Umbilical Cord Blood Transplantation, Incidence, Hematopoietic Stem Cell Transplantation, Infant, Newborn, Infant, Cell Biology, Hematology, medicine.disease, Surgery, Transplantation, Treatment Outcome, Child, Preschool, Histocompatibility, Cord blood, Female, Severe Combined Immunodeficiency, business
Abstract

Pediatric patients with SCID constitute medical emergencies. In the absence of an HLA-identical hematopoietic stem cell (HSC) donor, mismatched related-donor transplantation (MMRDT) or unrelated-donor umbilical cord blood transplantation (UCBT) are valuable treatment options. To help transplantation centers choose the best treatment option, we retrospectively compared outcomes after 175 MMRDTs and 74 UCBTs in patients with SCID or Omenn syndrome. Median follow-up time was 83 months and 58 months for UCBT and MMRDT, respectively. Most UCB recipients received a myeloablative conditioning regimen; most MMRDT recipients did not. UCB recipients presented a higher frequency of complete donor chimerism (P = .04) and faster total lymphocyte count recovery (P = .04) without any statistically significance with the preparative regimen they received. The MMRDT and UCBT groups did not differ in terms of T-cell engraftment, CD4+ and CD3+ cell recoveries, while Ig replacement therapy was discontinued sooner after UCBT (adjusted P = .02). There was a trend toward a greater incidence of grades II-IV acute GVHD (P = .06) and more chronic GVHD (P = .03) after UCBT. The estimated 5-year overall survival rates were 62% ± 4% after MMRDT and 57% ± 6% after UCBT. For children with SCID and no HLA-identical sibling donor, both UCBT and MMRDT represent available HSC sources for transplantation with quite similar outcomes.

Published
2012

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