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328 results on '"Vandenbussche, Frank P."'

12. Randomized Comparison of Nifedipine and Placebo in Fibronectin-Negative Women with Symptoms of Preterm Labor and a Short Cervix (APOSTEL-I Trial)

Author

Vis, Jolande Y., van Baaren, Gert-Jan, Wilms, Femke F., Oudijk, Martijn A., Kwee, Anneke, Porath, Martina M., Scheepers, Hubertina C., Spaanderman, Marc E., Bloemenkamp, Kitty W., van Lith, Jan M., Bolte, Antoinette C., Bax, Caroline J., Cornette, Jérôme, Duvekot, Johannes J., Nij Bijvank, Sebastiaan W., van Eyck, Jim, Franssen, Maureen T., Sollie, Krystyna M., Woiski, Mallory, Vandenbussche, Frank P., van der Post, Joris A., Bossuyt, Patrick M., Opmeer, Brent C., and Mol, Ben W.

Published
2015
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16. Predictive Value of Cervical Length Measurement and Fibronectin Testing in Threatened Preterm Labor

Author

van Baaren, Gert-Jan, Vis, Jolande Y., Wilms, Femke F., Oudijk, Martijn A., Kwee, Anneke, Porath, Martina M., Oei, Guid, Scheepers, Hubertina C. J., Spaanderman, Marc E. A., Bloemenkamp, Kitty W. M., Haak, Monique C., Bolte, Antoinette C., Bax, Caroline J., Cornette, Jérôme M. J., Duvekot, Johannes J., Nij Bijvanck, Bas W. A., van Eyck, Jim, Franssen, Maureen T. M., Sollie, Krystyna M., Vandenbussche, Frank P. H. A., Woiski, Mallory, Grobman, William A., van der Post, Joris A. M., Bossuyt, Patrick M. M., Opmeer, Brent C., and Mol, Ben W. J.

Published
2014
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25. Perinatal Outcome of Monoamniotic Twin Pregnancies

Author

Hack, Karien E., Derks, Jan B., Schaap, Arty H., Lopriore, Enrico, Elias, Sjoerd G., Arabin, Birgit, Eggink, Alex J., Sollie, Krystyna M., Mol, Ben Willem J., Duvekot, Hans J., Willekes, Christine, Go, Attie T., Koopman-Esseboom, Corine, Vandenbussche, Frank P., and Visser, Gerard H.

Published
2009
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32. Conflicting information

Author

Lopriore, Enrico, Sueters, Marieke, and Vandenbussche, Frank P.

Published
2007

41. Identification and complete genome sequencing of paramyxoviruses in mallard ducks (Anas platyrhynchos) using random access amplification and next generation sequencing technologies

Author

van den Berg Thierry, Vandenbussche Frank, Lambrecht Bénédicte, Rosseel Toon, and Van Borm Steven

Subjects
APMV4, APMV6, avian paramyxovirus, mallard, next generation sequencing, random amplification, SISPA, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background During a wildlife screening program for avian influenza A viruses (AIV) and avian paramyxoviruses (APMV) in Belgium, we isolated two hemagglutinating agents from pools of cloacal swabs of wild mallards (Anas platyrhynchos) caught in a single sampling site at two different times. AIV and APMV1 were excluded using hemagglutination inhibition (HI) testing and specific real-time RT-PCR tests. Methods To refine the virological identification of APMV2-10 realized by HI subtyping tests and in lack of validated molecular tests for APMV2-10, random access amplification was used in combination with next generation sequencing for the sequence independent identification of the viruses and the determination of their genomes. Results Three different APMVs were identified. From one pooled sample, the complete genome sequence (15054 nucleotides) of an APMV4 was assembled from the random sequences. From the second pooled sample, the nearly complete genome sequence of an APMV6 (genome size of 16236 nucleotides) was determined, as well as a partial sequence for an APMV4. This APMV4 was closely related but not identical to the APMV4 isolated from the first sample. Although a cross-reactivity with other APMV subtypes did not allow formal identification, the HI subtyping revealed APMV4 and APMV6 in the respective pooled samples but failed to identify the co-infecting APMV4 in the APMV6 infected pool. Conclusions These data further contribute to the knowledge about the genetic diversity within the serotypes APMV4 and 6, and confirm the limited sensitivity of the HI subtyping test. Moreover, this study demonstrates the value of a random access nucleic acid amplification method in combination with massive parallel sequencing. Using only a moderate and economical sequencing effort, the characterization and full genome sequencing of APMVs can be obtained, including the identification of viruses in mixed infections.

Published
2011
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43. Progesterone for the prevention of preterm birth in women with multiple pregnancies: the AMPHIA trial

Author

Scheepers Hubertina CJ, Santema Job G, van Oirschot Charlotte M, Offermans Jos PM, Mol Ben WJ, Hummel Pieter, Hasaart Tom HM, Erwich Jan Jaap HM, Duvekot Johannes J, Boer Kees, Bloemenkamp Kitty WM, Lim Arianne C, Schöls Willem A, Vandenbussche Frank PHA, Wouters Maurice GAJ, and Bruinse Hein W

Subjects
Gynecology and obstetrics, RG1-991
Abstract

Abstract Background 15% of multiple pregnancies ends in a preterm delivery, which can lead to mortality and severe long term neonatal morbidity. At present, no generally accepted strategy for the prevention of preterm birth in multiple pregnancies exists. Prophylactic administration of 17-alpha hydroxyprogesterone caproate (17OHPC) has proven to be effective in the prevention of preterm birth in women with singleton pregnancies with a previous preterm delivery. At present, there are no data on the effectiveness of progesterone in the prevention of preterm birth in multiple pregnancies. Methods/Design We aim to investigate the hypothesis that 17OHPC will reduce the incidence of the composite neonatal morbidity of neonates by reducing the early preterm birth rate in multiple pregnancies. Women with a multiple pregnancy at a gestational age between 15 and 20 weeks of gestation will be entered in a placebo-controlled, double blinded randomised study comparing weekly 250 mg 17OHPC intramuscular injections from 16–20 weeks up to 36 weeks of gestation versus placebo. At study entry, cervical length will be measured. The primary outcome is composite bad neonatal condition (perinatal death or severe morbidity). Secondary outcome measures are time to delivery, preterm birth rate before 32 and 37 weeks, days of admission in neonatal intensive care unit, maternal morbidity, maternal admission days for preterm labour and costs. We need to include 660 women to indicate a reduction in bad neonatal outcome from 15% to 8%. Analysis will be by intention to treat. We will also analyse whether the treatment effect is dependent on cervical length. Discussion This trial will provide evidence as to whether or not 17OHPC-treatment is an effective means of preventing bad neonatal outcome due to preterm birth in multiple pregnancies. Trial registration Current Controlled Trials ISRCTN40512715

Published
2007
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45. Pregnancy outcome after previous termination of pregnancy for preeclampsia

Author

Bolte, Antoinette C., van Eerden, Leonoor L., Zeeman, Gerda G., Page-Christiaens, Godelieve C., Pajkrt, Eva, Duvekot, Johannes J., Vandenbussche, Frank P., Oei, Guid, Scheepers, Liesbeth C., van Eyck, Jim, Middeldorp, Annemieke M., de Groot, Christianne J., Amsterdam Reproduction & Development (AR&D), Obstetrics and gynaecology, and ACS - Atherosclerosis & ischemic syndromes

Published
2017

46. Acardius anceps with neck cyst and cleft palate: Three dimensional skeletal computed tomography reconstruction with discussion of the literature.

Author

Gemert, Martin J. C., Streekstra, Geert J., Vandenbussche, Frank P. H. A., Nikkels, Peter G. J., and Wijngaard, Jeroen P. H. M.

Abstract

Acardiac twinning is a rare anomaly of monochorionic twin pregnancies. Acardiac fetuses lack a functional heart but are passively perfused by arterial blood from their pump co‐twin causing the acardiac body to be hypoxemic. In this report, we present an acardius anceps, therapeutically laser separated from its pump twin at 16 weeks. The healthy pump twin and macerated acardiac body were born at 40 3/7 weeks. A three dimensional (3D) reconstruction was made by CT images, showing cranial bones, spinal column, pelvis and lower extremities but absent arms. A cyst in the neck of the acardiac twin was identified by postnatal sonography; this was also described in four literature cases, and was additionally observed by us in two other acardiac twins. Median cleft palate was identified by oral cavity inspection but undetectable in the reconstruction. In the literature, we found 21 other acardiac anceps twins with a cleft palate. From the two larger published series, with 12 clefts in 21 acardiac anceps twins, a cleft palate occurs in over 50% during acardiac twinning. Our first hypothesis is that acardiac fetuses develop an oral cleft palate when acardiac onset starts prior to 11 weeks, because 11 weeks includes the period of embryonic oral cavity formation, and no cleft occurs when onset starts later than 11 weeks. Our second hypothesis is that cysts and cleft palates are more common in acardiac twins than currently known, likely reflecting that acardiac bodies are hypoxemic and that hypoxia contributes to the development of both cysts and clefts. [ABSTRACT FROM AUTHOR]

Published
2020
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48. Induction of Labour at 41 Weeks Versus Expectant Management Until 42 Weeks (Index): A Multicentre, Open-Label, Randomised Non-Inferiority Trial

Author

Keulen, Judit K., primary, Bruinsma, Aafke, additional, Kortekaas, Joep C, additional, van Dillen, Jeroen, additional, Bossuyt, Patrick M, additional, Oudijk, Martijn A, additional, Duijnhoven, Ruben G, additional, van Kaam, Anton H, additional, Vandenbussche, Frank P, additional, van der, Joris A, additional, Mol, Ben W, additional, and de Miranda, Esteriek, additional

Published
2018
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49. Which Factors Contribute to False-Positive, False-Negative, and Invalid Results in Fetal Fibronectin Testing in Women with Symptoms of Preterm Labor?

Author

Bruijn, Merel M C, Hermans, Frederik J R, Vis, Jolande Y., Wilms, Femke F., Oudijk, Martijn A., Kwee, Anneke, Porath, Martina M., Oei, Guid, Scheepers, Hubertina C. J., Spaanderman, Marc E. A., Bloemenkamp, Kitty W M, Haak, Monique C., Bolte, Antoinette C., Vandenbussche, Frank P. H. A., Woiski, Mallory D, Bax, Caroline J., Cornette, Jérôme M J, Duvekot, Johannes J., Bijvank, Bas W A N I J, van Eyck, Jim, Franssen, Maureen T. M., Sollie, Krystyna M., van der Post, Joris A. M., Bossuyt, Patrick M. M., Kok, Marjolein, Mol, Ben Willem J., van Baaren, Gert-Jan, Bruijn, Merel M C, Hermans, Frederik J R, Vis, Jolande Y., Wilms, Femke F., Oudijk, Martijn A., Kwee, Anneke, Porath, Martina M., Oei, Guid, Scheepers, Hubertina C. J., Spaanderman, Marc E. A., Bloemenkamp, Kitty W M, Haak, Monique C., Bolte, Antoinette C., Vandenbussche, Frank P. H. A., Woiski, Mallory D, Bax, Caroline J., Cornette, Jérôme M J, Duvekot, Johannes J., Bijvank, Bas W A N I J, van Eyck, Jim, Franssen, Maureen T. M., Sollie, Krystyna M., van der Post, Joris A. M., Bossuyt, Patrick M. M., Kok, Marjolein, Mol, Ben Willem J., and van Baaren, Gert-Jan

Published
2017

50. Hypothesis acardiac twin pregnancies : Pathophysiology-based hypotheses suggest risk prediction by pump/acardiac umbilical venous diameter ratios

Author

van Gemert, Martin J C, Pistorius, Lourens R., Benirschke, Kurt, Bonsel, Gouke J., Vandenbussche, Frank P H A, Paarlberg, K. Marieke, van den Wijngaard, Jeroen P H M, Nikkels, Peter G J, Biomedical Engineering and Physics, and Other departments

Subjects
Embryology, Umbilical venous diameter ratio (UVD-ratio), Acardiac twin pregnancy, Journal Article, Pediatrics, Perinatology, and Child Health, Pathophysiology, Risk prediction of pump twin, Serial UVD-ratio measurement, Twin reversed-arterial perfusion sequence, Developmental Biology
Abstract

BACKGROUND: A total of 75% of monozygotic twins share 1 monochorionic placenta where placental anastomoses cause several serious complications, for example, acardiac twinning. Acardiac twins lack cardiac function but grow by perfusion of arterial blood from the pump twin. This rare pregnancy has 50% natural pump twin mortality but accurate risk prediction is currently impossible. Recent guidelines suggest prophylactic surgery before 18 weeks, suggesting 50% unnecessary interventions. We hypothesize that (1) adverse pump twin outcome relates to easy-to-measure pump/acardiac umbilical venous diameter (UVD) ratios, representing acardiac perfusion by the pump's excess cardiac output. This hypothesis suggests that (2) UVD-ratios are large, mildly varying in cases without complications but small and decreasing when complications develop, thus predicting that (3) UVD-ratios may allow risk prediction of pump twins. In this exploratory clinical pilot, we tested whether UVD-ratio measurements support these predictions. METHODS: We included 7 uncomplicated (expectant management), 3 elective surgical, and 17 complicated cases (pump decompensation, emergency intervention/delivery or demise). Nine UVD-ratios were measured sonographycally and 18 by pathology. RESULTS: Uncomplicated cases have larger, two serial measurements showing mildly varying UVD-ratios; elective surgical cases show larger UVD-ratios; complicated cases have smaller, two serial measurements showing decreasing UVD-ratios. There were no false-positives, no false-negatives and noncrossing linear trendlines of uncomplicated and complicated cohorts. CONCLUSION: Our data provide first evidence that UVD-ratios allow risk prediction of pump twins. More early uncomplicated and late complicated cases are needed, for example, in a prospective trial, before the separation between uncomplicated and complicated cohorts is accurate enough to support a well-founded decision on (early) intervention.

Published
2016

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