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714 results on '"Vandenberghe, Wim"'

2. Genotype–phenotype correlation in PRKN-associated Parkinson’s disease

Author

Menon, Poornima Jayadev, Sambin, Sara, Criniere-Boizet, Baptiste, Courtin, Thomas, Tesson, Christelle, Casse, Fanny, Ferrien, Melanie, Mariani, Louise-Laure, Carvalho, Stephanie, Lejeune, Francois-Xavier, Rebbah, Sana, Martet, Gaspard, Houot, Marion, Lanore, Aymeric, Mangone, Graziella, Roze, Emmanuel, Vidailhet, Marie, Aasly, Jan, Gan Or, Ziv, Yu, Eric, Dauvilliers, Yves, Zimprich, Alexander, Tomantschger, Volker, Pirker, Walter, Álvarez, Ignacio, Pastor, Pau, Di Fonzo, Alessio, Bhatia, Kailash P., Magrinelli, Francesca, Houlden, Henry, Real, Raquel, Quattrone, Andrea, Limousin, Patricia, Korlipara, Prasad, Foltynie, Thomas, Grosset, Donald, Williams, Nigel, Narendra, Derek, Lin, Hsin-Pin, Jovanovic, Carna, Svetel, Marina, Lynch, Timothy, Gallagher, Amy, Vandenberghe, Wim, Gasser, Thomas, Brockmann, Kathrin, Morris, Huw R., Borsche, Max, Klein, Christine, Corti, Olga, Brice, Alexis, Lesage, Suzanne, and Corvol, Jean Christophe

Published
2024
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4. VI.Waste

Author

Calster*, Geert van, primary and Vandenberghe**, Wim, additional

Published
2023
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14. A Case of Chorea with Slow Saccades Caused by NKX2‐1 Mutation.

Author

Vercammen, Johanna, Terryn, Joke, Van Daele, Sien, Vermeer, Sascha, and Vandenberghe, Wim

Subjects
MOVEMENT disorders, CHOREA, MYOCLONUS, HUNTINGTON disease, GENETIC mutation, INFORMED consent (Medical law), SYNCOPE
Abstract

This article discusses a case of chorea with slow saccades caused by a mutation in the NKX2-1 gene. Chorea is characterized by involuntary movements, and slow saccades refer to slow eye movements. The patient in this case study experienced chorea and slow saccades, along with other symptoms such as delayed motor and speech milestones, mild asthma, and mildly elevated thyroid stimulating hormone levels. The article highlights that slow saccades are not typically associated with NKX2-1-related disorder, but this case suggests that it should be considered as a possible cause. [Extracted from the article]

Published
2024
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15. The eye as a window to the brain: hyperspectral retinal imaging as a biomarker for Alzheimer’s disease

Author

Dahdouh‐Guebas, Yasmin, primary, Kulenovic, Hana, additional, Christinaki, Eirini, additional, Van Eijgen, Jan, additional, Lemmens, Sophie, additional, Ceccarini, Jenny, additional, Rousseau, Frederic, additional, Schymkowitz, Joost, additional, Vandenbulcke, Mathieu, additional, Vandenberghe, Wim, additional, Vandenberghe, Rik, additional, De Strooper, Bart, additional, Jayapala, Murali, additional, Blaschko, Matthew, additional, Moons, Lieve, additional, Stalmans, Ingeborg, additional, and De Groef, Lies, additional

Published
2023
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18. Testing of symmetric biphasic stimulation in Vim-DBS ET patients: a randomized-controlled pilot study.

Author

Boogers, Alexandra, Peeters, Jana, Van Bogaert, Tine, De Vloo, Philippe, Vandenberghe, Wim P., Nuttin, Bart, and Mc Laughlin, Myles

Subjects
MONTREAL Cognitive Assessment, ESSENTIAL tremor, PILOT projects, REMOTE control, DEEP brain stimulation
Abstract

Introduction: Symmetric biphasic pulses have been shown to increase the therapeutic window compared to standard cathodic pulses in ET Vim-DBS patients. Furthermore, three hours of stimulation with biphasic pulses caused less stimulation-induced ataxia compared to cathodic pulses. Therefore, an investigation of the longer-term safety of biphasic pulses is warranted. Methods: Seven ET patients were included in a randomized double-blind, cross-over design of one week home-use of symmetric biphasic stimulation (anodic phase first) versus cathodic stimulation. Amplitude was set in a doubleblinded way, at the tremor arrest threshold. The primary outcome was safety assessed by documenting the adverse events. Secondary outcome parameters were stimulation amplitude, tremor (Fahn-Tolosa-Marin Tremor Rating Scale) and ataxia (International Cooperative Ataxia Rating Scale) severity, quality of life (Quality of Life in Essential Tremor Questionnaire) and cognition (Montreal Cognitive Assessment). Three patients continued in the open-label extension phase for 3 months, during which biphasic stimulation-only was further assessed by the same outcome parameters. Results: During the 1 week testing, no adverse effects were reported. To obtain equivalent tremor control, the amplitude of the biphasic pulse was significantly higher compared to that of the cathodic pulse (p = 0.003). The other outcome parameters were not significantly different. During the open-label study, one patient used the remote control to increase the amplitude, leading to two falls caused by stimulation-induced ataxia. No other adverse effects occurred. Discussion and conclusion: In a small cohort, when tested for one week, symmetric biphasic pulses suggest to be safe, but require higher stimulation amplitudes. Further follow-up studies are needed to investigate long-term effects and safety. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Neuroimaging to Facilitate Clinical Trials in Huntington's Disease: Current Opinion from the EHDN Imaging Working Group.

Author

Hobbs, Nicola Z., Papoutsi, Marina, Delva, Aline, Kinnunen, Kirsi M., Nakajima, Mitsuko, Van Laere, Koen, Vandenberghe, Wim, Herath, Priyantha, and Scahill, Rachael I.

Subjects
MAGNETIC resonance imaging, POSITRON emission tomography, HUNTINGTON disease, NUCLEAR magnetic resonance spectroscopy, PERFUSION imaging
Abstract

Neuroimaging is increasingly being included in clinical trials of Huntington's disease (HD) for a wide range of purposes from participant selection and safety monitoring, through to demonstration of disease modification. Selection of the appropriate modality and associated analysis tools requires careful consideration. On behalf of the EHDN Imaging Working Group, we present current opinion on the utility and future prospects for inclusion of neuroimaging in HD trials. Covering the key imaging modalities of structural-, functional- and diffusion- MRI, perfusion imaging, positron emission tomography, magnetic resonance spectroscopy, and magnetoencephalography, we address how neuroimaging can be used in HD trials to: 1) Aid patient selection, enrichment, stratification, and safety monitoring; 2) Demonstrate biodistribution, target engagement, and pharmacodynamics; 3) Provide evidence for disease modification; and 4) Understand brain re-organization following therapy. We also present the challenges of translating research methodology into clinical trial settings, including equipment requirements and cost, standardization of acquisition and analysis, patient burden and invasiveness, and interpretation of results. We conclude, that with appropriate consideration of modality, study design and analysis, imaging has huge potential to facilitate effective clinical trials in HD. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Mild Motor Signs in Healthy Aging Are Associated with Lower Synaptic Density in the Brain

Author

Van Cauwenberge, Margot G.A., primary, Delva, Aline, additional, Vande Casteele, Thomas, additional, Laroy, Maarten, additional, Radwan, Ahmed, additional, Vansteelandt, Kristof, additional, Van den Stock, Jan, additional, Bouckaert, Filip, additional, Van Laere, Koen, additional, Emsell, Louise, additional, Vandenberghe, Wim, additional, and Vandenbulcke, Mathieu, additional

Published
2023
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32. Active and Passive Cycling Decrease Subthalamic β Oscillations in Parkinson's Disease.

Author

Bougou, Vasiliki, Vanhoyland, Michaël, Decramer, Thomas, Van Hoylandt, Anaïs, Smeijers, Steven, Nuttin, Bart, De Vloo, Philippe, Vandenberghe, Wim, Nieuwboer, Alice, Janssen, Peter, and Theys, Tom

Abstract

Background: Preserved cycling capabilities in patients with Parkinson's disease, especially in those with freezing of gait are still poorly understood. Previous research with invasive local field potential recordings in the subthalamic nucleus has shown that cycling causes a stronger suppression of β oscillations compared to walking, which facilitates motor continuation. Methods: We recorded local field potentials from 12 patients with Parkinson's disease (six without freezing of gait, six with freezing of gait) who were bilaterally implanted with deep brain stimulation electrodes in the subthalamic nucleus. We investigated β (13–30 Hz) and high γ (60–100 Hz) power during both active and passive cycling with different cadences and compared patients with and without freezing of gait. The passive cycling experiment, where a motor provided a fixed cadence, allowed us to study the effect of isolated sensory inputs without physical exercise. Results: We found similarly strong suppression of pathological β activity for both active and passive cycling. In contrast, there was stronger high γ band activity for active cycling. Notably, the effects of active and passive cycling were all independent of cadence. Finally, β suppression was stronger for patients with freezing of gait, especially during passive cycling. Conclusions: Our results provide evidence for a link between proprioceptive input during cycling and β suppression. These findings support the role of continuous external sensory input and proprioceptive feedback during rhythmic passive cycling movements and suggest that systematic passive mobilization might hold therapeutic potential. © 2023 International Parkinson and Movement Disorder Society. Cycling's impact on Parkinson's disease, particularly freezing of gait, is poorly understood. Invasive subthalamic recordings from 12 deep brain stimulation patients show equivalent β suppression during active and passive cycling, independent of cadence, with a stronger effect in freezing of gait patients. Proprioceptive input during cycling links to β suppression. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Contributors

Author

Albright, Robert C., primary, Amerling, Richard, additional, Angeli, Paolo, additional, Angelotti, Maria Lucia, additional, Antonelli, Massimo, additional, Antoniotti, Riccardo, additional, Arulkumaran, Nishkantha, additional, Asfar, Pierre, additional, Ash, Stephen R., additional, Aucella, Filippo, additional, Aucella, Francesco, additional, Ave, Samuele, additional, Bagshaw, Sean M., additional, Balaraman, Vasanthi, additional, Baldwin, Ian, additional, Bargman, Joanne M., additional, Barletta, Gina-Marie, additional, Barletta, Jeffrey F., additional, Barnela, Shriganesh R., additional, Bayır, Hülya, additional, Beaulieu, Monica, additional, Bellasi, Antonio, additional, Bellomo, Rinaldo, additional, Beloncle, François, additional, Bhansali, Arjun, additional, Bihorac, Azra, additional, Billings, Frederic T., additional, Birk, Horst-Walter, additional, Bonilla-Reséndiz, Luis Ignacio, additional, Bouchard, Josée, additional, Bourke, Edmund, additional, Braitberg, George, additional, Brendolan, Alessandra, additional, Brocca, Alessandra, additional, Brophy, Patrick D., additional, Bucala, Richard, additional, Bunchman, Timothy E., additional, Burdmann, Emmanuel A., additional, Busse, Laurence W., additional, Caires, Renato Antunes, additional, Caironi, Pietro, additional, Camilla, Roberta, additional, Campos, Israel, additional, Canaud, Bernard, additional, Cantaluppi, Vincenzo, additional, Martinez, Maria P., additional, Capasso, Giovambattista, additional, Carcillo, Joseph A., additional, Carlesso, Eleonora, additional, Casino, Francesco G., additional, Castellano, Giuseppe, additional, Catania, Matteo, additional, Cawcutt, Kelly A., additional, Cerda, Jorge, additional, Charen, Elliot, additional, Chawla, Lakhmir S., additional, Chiaramonte, Stefano, additional, Chua, Horng-Ruey, additional, Cianciaruso, Bruno, additional, Ciceri, Paola, additional, Cieslak, Jacek, additional, Clark, William R., additional, Claure-Del Granado, Rolando, additional, Clementi, Anna, additional, Co, Ivan N., additional, Coelho, Fernanda Oliveira, additional, Conte, Ferruccio, additional, Corey, Howard E., additional, Cosmai, Laura, additional, Costalonga, Elerson Carlos, additional, Costamagna, Andrea, additional, Costanzo, Maria Rosa, additional, Cozzolino, Mario, additional, Cramer, Carl H., additional, Cravedi, Paolo, additional, Crepaldi, Carlo, additional, Creteur, Jacques, additional, Crew, R. John, additional, da Costa e Silva, Verônica Torres, additional, Davenport, Andrew, additional, Davies, Andrew R., additional, D'Costa, Rohit, additional, Dean, Dawson F., additional, Debiais, Charlotte, additional, de Cal, Massimo, additional, Dedhia, Paras, additional, de Grooth, Harm-Jan, additional, Dell'Aquila, Roberto, additional, Dellepiane, Sergio, additional, Dellinger, Richard Phillip, additional, Del Vecchio, Lucia, additional, Depner, Thomas A., additional, De Rosa, Silvia, additional, Deutschman, Clifford S., additional, Devarajan, Prasad, additional, Dewitte, A., additional, Di Iorio, Biagio R., additional, Di Lullo, Luca, additional, Di Micco, Lucia, additional, Di Nardo, Matteo, additional, Ding, Xiaoqiang, additional, D'Ippoliti, Fiorella, additional, Di Somma, Salvatore, additional, Doi, Kent, additional, Dries, David J., additional, Druml, Wilfred, additional, Duke, Graeme, additional, Durand, Francois, additional, Eadon, Michael T., additional, Eckstein, Devin, additional, Egi, Moritoki, additional, Eiam-Ong, Somchai, additional, Elbers, Paul W.G., additional, Elli, Francesca, additional, Elliott, Steve, additional, Emlet, David R., additional, Endre, Zoltan, additional, Evans, Roger G., additional, Fanelli, Vito, additional, Fattahi, Fatemeh, additional, Federspiel, Christine Kinggaard, additional, Ferrada, Marcela A., additional, Ferrari, Fiorenza, additional, Fiaccadori, Enrico, additional, Fiorentino, Marco, additional, Fisher, Caleb, additional, Flessner, Michael F., additional, Formica, Marco, additional, Forni, Lui G., additional, Francoz, Claire, additional, French, Craig, additional, Fuhrman, Dana Y., additional, Fumagalli, Giordano, additional, Galbusera, Miriam, additional, Gallieni, Maurizio, additional, Gammill, Hilary S., additional, Gao, Dayong, additional, Garzotto, Francesco, additional, Gatta, Giuseppe, additional, Genga, Kelly R., additional, Genovesi, Simonetta, additional, Genyk, Yuri S., additional, Geradin, Christel, additional, Gesualdo, Loreto, additional, Giavarina, Davide, additional, Giuliani, Anna, additional, Glezerman, Ilya G., additional, Goldstein, Stuart L., additional, Golper, Thomas A., additional, Gómez, Hernando, additional, Granata, Antonio, additional, Grandaliano, Giuseppe, additional, Grasselli, Giacomo, additional, Groeneveld, A.B. Johan, additional, Guerci, Philippe, additional, Gunnerson, Kyle J., additional, Harbord, Nikolas, additional, Harshman, Lyndsay A., additional, Hennessy, Anthony J., additional, Hill, Graham L., additional, Hobson, Charles, additional, Hohenstein, Bernd, additional, Honoré, Patrick M., additional, Horwitz, Edward, additional, Hosseinian, Leila, additional, Hoste, Eric A.J., additional, House, Andrew A., additional, Humes, H. David, additional, Husain-Syed, Faeq, additional, Ince, Can, additional, Ing, Todd S., additional, Jacobs, Rita, additional, Jaswal, Dharmvir, additional, Jeyabalan, Arun, additional, Joannes-Boyau, Olivier, additional, Joannidis, Michael, additional, Joyce, Emily, additional, Kane-Gill, Sandra L., additional, Kaplan, Lewis J., additional, Kashani, Kianoush, additional, Katz, Nevin, additional, Kellum, John A., additional, Khanna, Ramesh, additional, Kim-Campbell, Nahmah, additional, King, Joshua D., additional, Kirwan, Christopher J., additional, Kiss, Joseph E., additional, Klein, David, additional, Kotanko, Peter, additional, Krediet, Raymond T., additional, Kuhlmann, Martin K., additional, Kuiper, Jan Willem, additional, Lachance, Philippe, additional, Lameire, Norbert, additional, Langer, Thomas, additional, Lankadeva, Yugeesh R., additional, Laurin, Louis-Philippe, additional, Lazzeri, Elena, additional, Leblanc, Martine, additional, Lefebvre, Joannie, additional, Lentini, Paolo, additional, Leray-Moragués, Hélène, additional, Levin, Adeera, additional, Lew, Susie Q., additional, Liapis, Helen, additional, Liu, Kathleen D., additional, Livigni, Sergio, additional, Locatelli, Francesco, additional, Lorenzin, Anna, additional, Lu, Jian-Da, additional, Lu, Renhua, additional, Lysak, Nicholas, additional, Macedo, Etienne, additional, Madan, Niti, additional, Madore, François, additional, Maerz, Linda L., additional, Maiden, Matthew J., additional, Malhotra, Rakesh, additional, Marengo, Marita, additional, Mariano, Filippo, additional, Marik, Paul E., additional, Marini, John J., additional, Marino, Rossella, additional, Marshall, Mark R., additional, Mårtensson, Johan, additional, Matsuura, Ryo, additional, May, Clive N., additional, Mazzone, Patrizio, additional, McCauley, Jerry, additional, McCullough, Peter A., additional, McMahon, Blaithin A., additional, Mehta, Ravindra L., additional, Mele, Caterina, additional, Menon, Madhav, additional, Meola, Mario, additional, Mérouani, Aicha, additional, Meuwly, Jean-Yves, additional, Milla, Paola, additional, Misra, Madhukar, additional, Misra, Paraish S., additional, Mizock, Barry A., additional, Modi, Jwalant R., additional, Moeckel, Gilbert, additional, Molitoris, Bruce A., additional, Morabito, Santo, additional, Mucelli, Roberto Pozzi, additional, Murray, Patrick T., additional, Murugan, Raghavan, additional, Nadim, Mitra K., additional, Nair, Devika, additional, Nalesso, Federico, additional, Neri, Mauro, additional, Nguyen, Trung C., additional, Ni, Zhaohui, additional, Noris, Marina, additional, Novick, Tessa, additional, O'Horo, John C., additional, Okusa, Mark Douglas, additional, Opal, Steven M., additional, Opdam, Helen Ingrid, additional, Ostermann, Marlies, additional, Ottaviano, Emerenziana, additional, Oudemans-van Straaten, Heleen M., additional, Overgaard-Steensen, Christian, additional, Padalino, Massimo A., additional, Panichi, Vincenzo, additional, Parameswaran, Priyanka, additional, Patel, Samir S., additional, Payen, Didier, additional, Pea, Federico, additional, Peacock, W. Frank, additional, Peart, Sandrica Young, additional, Peerapornratana, Sadudee, additional, Pelosi, Paolo, additional, Peng, Zhi-Yong, additional, Perico, Norberto, additional, Peruzzi, Licia, additional, Pesce, Francesco, additional, Pesenti, Antonio, additional, Petrucci, Ilaria, additional, Pham, Phuong-Chi, additional, Pham, Phuong-Thu, additional, Phoon, Richard K.S., additional, Piano, Salvatore, additional, Pinsky, Michael R., additional, Piquilloud, Lise, additional, Pistolesi, Valentina, additional, Plank, Lindsay D., additional, Plötz, Frans B., additional, Podestá, Manuel Alfredo, additional, Porta, Camillo, additional, Pozzato, Marco, additional, Prencipe, Michele, additional, Prowle, John R., additional, Puthucheary, Zudin A., additional, Qu, Lirong, additional, Rachoin, Jean-Sebastien, additional, Radhakrishnan, Jai, additional, Ranieri, V. Marco, additional, Ratanarat, Ranistha, additional, Remuzzi, Giuseppe, additional, Resnick, Shelby, additional, Rewa, Oleksa G., additional, Ricci, Zaccaria, additional, Ridel, Christophe, additional, Rifai, Kinan, additional, Ring, Troels, additional, Rizo-Topete, Lilia M., additional, Roessler, Eric, additional, Romagnani, Paola, additional, Romagnoli, Stefano, additional, Ronco, Claudio, additional, Ronco, Federico, additional, Rosner, Mitchell H., additional, Rossetti, Emanuele, additional, Russell, James A., additional, Saab, Georges, additional, Sabatino, Alice, additional, Saboo, Sonali S., additional, Samoni, Sara, additional, Sappington, Penny Lynn, additional, Sartori, Marco, additional, Savige, Judy, additional, Schena, Francesco Paolo, additional, Schneider, Antoine Guillaume, additional, Schraverus, Pieter, additional, Schulte, Wibke, additional, Segoloni, Giuseppe, additional, Semler, Matthew W., additional, Sharma, Aashish, additional, Shaw, Andrew, additional, Sheth, Naitik, additional, Shukla, Ashutosh, additional, Siddall, Eric C., additional, Sievers, Theodore M., additional, Siew, Edward D., additional, Singbartl, Kai, additional, Singer, Mervyn, additional, Singh, Pooja, additional, Smith, Loren E., additional, Soni, Sachin S., additional, Soto, Mara Serrano, additional, Spapen, Herbert D., additional, Srisawat, Nattachai, additional, Srivastava, Ajay, additional, Stellin, Giovanni, additional, Symons, Jordan M., additional, Szamosfalvi, Balazs, additional, Tai, Kian Bun, additional, Takalkar, Unmesh V., additional, Teitelbaum, Isaac, additional, Tetta, Ciro, additional, Thakar, Charuhas V., additional, Tonon, Marta, additional, Trepiccione, Francesco, additional, Triulzi, Darrell, additional, Tushar, Chopra, additional, Uchino, Shigehiko, additional, Valika, Ali, additional, Van Biesen, Wim, additional, Vandenberghe, Wim, additional, Vanholder, Raymond, additional, Vanmassenhove, Jill, additional, Verbine, Anton, additional, Vergano, Marco, additional, Villa, Gianluca, additional, Villeneuve, Pierre-Marc, additional, Vincent, Jean-Louis, additional, Vinsonneau, Christophe, additional, Virzì, Grazia Maria, additional, Visconti, Federico, additional, Visvanathan, Ravindran, additional, Van Vong, Li, additional, Walmrath, Hans-Dieter, additional, Ward, Peter A., additional, Weir, Matthew A., additional, Wen, Xiaoyan, additional, Wendon, Julia, additional, Winchester, James Frank, additional, Wong, Adrian, additional, Woodhouse, Elke L., additional, Xue, Jun, additional, Yadav, Anju, additional, Yerram, Preethi, additional, Yessayan, Lenar, additional, Yeun, Jane Y., additional, Yu, Alex W., additional, Zaccaria, Marta, additional, Zacchia, Miriam, additional, Zachariah, Teena P., additional, Zamperetti, Nereo, additional, Zampieri, Fernando G., additional, Zanco, Pierluigi, additional, Zanella, Alberto, additional, Zanoli, Luca, additional, Zappitelli, Michael, additional, Zaragoza, Jose J., additional, Zarbock, Alexander, additional, Zaroccolo, Marta, additional, Zhang, Han, additional, and Zimmer, Andrea, additional

Published
2019
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35. A Multinational Observational Study Exploring Adherence With the Kidney Disease: Improving Global Outcomes Recommendations for Prevention of Acute Kidney Injury After Cardiac Surgery

Author

Küllmar, Mira, Weiß, Raphael, Ostermann, Marlies, Campos, Sara, Grau Novellas, Neus, Thomson, Gary, Haffner, Michael, Arndt, Christian, Wulf, Hinnerk, Irqsusi, Marc, Monaco, Fabrizio, Di Prima, Ambra Licia, García-Alvarez, Mercedes, Italiano, Stefano, Felipe Correoso, Mar, Kunst, Gudrun, Nair, Shrijit, L’Acqua, Camilla, Hoste, Eric, Vandenberghe, Wim, Honore, Patrick M., Kellum, John A., Forni, Lui, Grieshaber, Philippe, Wempe, Carola, Meersch, Melanie, and Zarbock, Alexander

Published
2020
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37. Genotype-Phenotype correlation in Parkin-Parkinson’s disease (P3-11.012)

Author

Menon, Poornima Jayadev, primary, Sambin, Sara, additional, Criniere-Boizet, Baptiste, additional, Courtin, Thomas, additional, Casse, Fanny, additional, Tesson, Christelle, additional, Ferrien, Melanie, additional, Flamand-Roze, Emmanuel, additional, Lejeune, Francois-Xavier, additional, Lanore, Aymeric, additional, Mangone, Graziella, additional, Mariani, Louise-Laure, additional, Aasly, Jan, additional, Or, Ziv Gan, additional, Yu, Eric, additional, Dauvilliers, Yves, additional, Zimprich, Alexander, additional, Fernandez, Ignacio Alvarez, additional, Pastor, Pau, additional, Di Fonzo, Alessio, additional, Bhatia, Khailash, additional, Magrinelli, Francesca, additional, Houlden, Henry, additional, Real, Raquel, additional, Narendra, Derek, additional, Lin, Hsin-Pin, additional, Jovanovic, Carna, additional, Koks, Sulev, additional, Lynch, Timothy, additional, Gallagher, Amy, additional, Vandenberghe, Wim, additional, Gasser, Thomas, additional, Morris, Huw, additional, Klein, Christine, additional, Brockmann, Kathrin, additional, Corti, Olga, additional, Brice, Alexis, additional, Lesage, Suzanne, additional, and Corvol, Jean-Christophe, additional

Published
2023
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39. Potential of Urine Biomarkers CHI3L1, NGAL, TIMP-2, IGFBP7, and Combinations as Complementary Diagnostic Tools for Acute Kidney Injury after Pediatric Cardiac Surgery: A Prospective Cohort Study

Author

Vandenberghe, Wim, primary, De Loor, Jorien, additional, Francois, Katrien, additional, Vandekerckhove, Kristof, additional, Herck, Ingrid, additional, Vande Walle, Johan, additional, Peperstraete, Harlinde, additional, Bové, Thierry, additional, De Wolf, Daniël, additional, Nuytinck, Lieve, additional, De Waele, Jan J., additional, Meyer, Evelyne, additional, and Hoste, Eric A. J., additional

Published
2023
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40. Biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2 trial): study protocol for an international, prospective, randomised controlled multicentre trial

Author

von Groote, Thilo, primary, Meersch, Melanie, additional, Romagnoli, Stefano, additional, Ostermann, Marlies, additional, Ripollés-Melchor, Javier, additional, Schneider, Antoine Guillaume, additional, Vandenberghe, Wim, additional, Monard, Céline, additional, De Rosa, Silvia, additional, Cattin, Lucia, additional, Rahmel, Tim, additional, Adamzik, Michael, additional, Parise, Diego, additional, Candela-Toha, Angel, additional, Haaker, Jan Gerrit, additional, Göbel, Ulrich, additional, Bernard, Alice, additional, Lumlertgul, Nuttha, additional, Fernández-Valdes-Bango, Paula, additional, Romero Bhathal, Irene, additional, Suarez-de-la-Rica, A, additional, Larmann, Jan, additional, Villa, Gianluca, additional, Spadaro, Savino, additional, Wulf, Hinnerk, additional, Arndt, Christian, additional, Putensen, Christian, additional, García-Álvarez, Raquel, additional, Brandenburger, Timo, additional, Siniscalchi, Antonio, additional, Ellerkmann, Richard, additional, Espeter, Florian, additional, Porschen, Christian, additional, Sadjadi, Mahan, additional, Saadat-Gilani, Khaschayar, additional, Weiss, Raphael, additional, Gerss, Joachim, additional, Kellum, John, additional, and Zarbock, Alexander, additional

Published
2023
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41. Biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2 trial): study protocol for an international, prospective, randomised controlled multicentre trial

Author

von Groote, Thilo; https://orcid.org/0000-0002-5287-1137, Meersch, Melanie; https://orcid.org/0000-0002-6011-8049, Romagnoli, Stefano, Ostermann, Marlies, Ripollés-Melchor, Javier, Schneider, Antoine Guillaume; https://orcid.org/0000-0003-0576-7094, Vandenberghe, Wim; https://orcid.org/0000-0001-5464-7940, Monard, Céline, De Rosa, Silvia; https://orcid.org/0000-0001-8987-4596, Cattin, Lucia, Rahmel, Tim, Adamzik, Michael, Parise, Diego, Candela-Toha, Angel, Haaker, Jan Gerrit, Göbel, Ulrich, Bernard, Alice, Lumlertgul, Nuttha; https://orcid.org/0000-0003-1506-4253, Fernández-Valdes-Bango, Paula, Romero Bhathal, Irene, Suarez-de-la-Rica, A, Larmann, Jan; https://orcid.org/0000-0003-3365-4572, Villa, Gianluca, Spadaro, Savino, Wulf, Hinnerk, Arndt, Christian, Putensen, Christian, García-Álvarez, Raquel, Brandenburger, Timo, Siniscalchi, Antonio, et al, BigpAK-2 Investigators, Hilty, Matthias; https://orcid.org/0000-0002-2765-881X, Spanaus, Katharina; https://orcid.org/0000-0003-1903-0122, von Groote, Thilo; https://orcid.org/0000-0002-5287-1137, Meersch, Melanie; https://orcid.org/0000-0002-6011-8049, Romagnoli, Stefano, Ostermann, Marlies, Ripollés-Melchor, Javier, Schneider, Antoine Guillaume; https://orcid.org/0000-0003-0576-7094, Vandenberghe, Wim; https://orcid.org/0000-0001-5464-7940, Monard, Céline, De Rosa, Silvia; https://orcid.org/0000-0001-8987-4596, Cattin, Lucia, Rahmel, Tim, Adamzik, Michael, Parise, Diego, Candela-Toha, Angel, Haaker, Jan Gerrit, Göbel, Ulrich, Bernard, Alice, Lumlertgul, Nuttha; https://orcid.org/0000-0003-1506-4253, Fernández-Valdes-Bango, Paula, Romero Bhathal, Irene, Suarez-de-la-Rica, A, Larmann, Jan; https://orcid.org/0000-0003-3365-4572, Villa, Gianluca, Spadaro, Savino, Wulf, Hinnerk, Arndt, Christian, Putensen, Christian, García-Álvarez, Raquel, Brandenburger, Timo, Siniscalchi, Antonio, et al, BigpAK-2 Investigators, Hilty, Matthias; https://orcid.org/0000-0002-2765-881X, and Spanaus, Katharina; https://orcid.org/0000-0003-1903-0122

Abstract

IntroductionPrevious studies demonstrated that the implementation of the Kidney Disease Improving Global Outcomes (KDIGO) guideline-based bundle, consisting of different supportive measures in patients at high risk for acute kidney injury (AKI), might reduce rate and severity of AKI after surgery. However, the effects of the care bundle in broader population of patients undergoing surgery require confirmation.Methods and analysisThe BigpAK-2 trial is an international, randomised, controlled, multicentre trial. The trial aims to enrol 1302 patients undergoing major surgery who are subsequently admitted to the intensive care or high dependency unit and are at high-risk for postoperative AKI as identified by urinary biomarkers (tissue inhibitor of metalloproteinases 2*insulin like growth factor binding protein 7 (TIMP-2)*IGFBP7)). Eligible patients will be randomised to receive either standard of care (control) or a KDIGO-based AKI care bundle (intervention). The primary endpoint is the incidence of moderate or severe AKI (stage 2 or 3) within 72 hours after surgery, according to the KDIGO 2012 criteria. Secondary endpoints include adherence to the KDIGO care bundle, occurrence and severity of any stage of AKI, change in biomarker values during 12 hours after initial measurement of (TIMP-2)*(IGFBP7), number of free days of mechanical ventilation and vasopressors, need for renal replacement therapy (RRT), duration of RRT, renal recovery, 30-day and 60-day mortality, intensive care unit length-of-stay and hospital length-of-stay and major adverse kidney events. An add-on study will investigate blood and urine samples from recruited patients for immunological functions and kidney damage.Ethics and disseminationThe BigpAK-2 trial was approved by the Ethics Committee of the Medical Faculty of the University of Münster and subsequently by the corresponding Ethics Committee of the participating sites. A study amendment was approved subsequently. In the UK, the trial was adopt

Published
2023

46. Video-assisted thoracic surgery in critically ill COVID-19 patients on venovenous extracorporeal membrane oxygenation.

Author

Zwaenepoel, Bert, Vandewiele, Korneel, Peperstraete, Harlinde, De Ryck, Frederic, Vanpeteghem, Caroline, Malfait, Thomas, Herck, Ingrid, Vandenberghe, Wim, Van Laethem, Lien, Defreyne, Luc, Van Braeckel, Eva, Depuydt, Pieter, and Schaubroeck, Hannah

Subjects
PERIOPERATIVE care, INTENSIVE care units, THROMBOSIS, SURGICAL blood loss, COVID-19, RESPIRATORY insufficiency, CRITICALLY ill, PATIENTS, EXTRACORPOREAL membrane oxygenation, RETROSPECTIVE studies, THERAPEUTIC embolization, MANN Whitney U Test, HEMOTHORAX, CHI-squared test, DESCRIPTIVE statistics, VIDEO-assisted thoracic surgery, DATA analysis software, PATIENT safety
Abstract

Introduction: Coronavirus disease 2019 (COVID-19) leads to thoracic complications requiring surgery. This is challenging, particularly in patients supported with venovenous extracorporeal membrane oxygenation (VV-ECMO) due to the need for continuous therapeutic anticoagulation. We aim to share our experience regarding the safety and perioperative management of video-assisted thoracic surgery for this specific population. Methods: Retrospective, single-center study between November 2020 and January 2022 at the ICU department of a 1.061-bed tertiary care and VV-ECMO referral center during the COVID-19 pandemic. Results: 48 COVID-19 patients were supported with VV-ECMO. A total of 14 video-assisted thoracic surgery (VATS) procedures were performed in seven patients. Indications were mostly hemothorax (85.7%). In eight procedures heparin was stopped at least 1 h before incision. A total of 10 circuit changes due to clot formation or oxygen transfer failure were required in six patients (85.7%). One circuit replacement seemed related to the preceding VATS procedure, although polytransfusion might be a contributing factor. None of the mechanical complications was fatal. Four VATS-patients (57.1%) died, of which two (50%) immediately perioperatively due to uncontrollable bleeding. All three survivors were treated with additional transarterial embolization. Conclusion: (1) Thoracic complications in COVID-19 patients on VV-ECMO are common. (2) Indication for VATS is mostly hemothorax (3) Perioperative mortality is high, mostly due to uncontrollable bleeding. (4) Preoperative withdrawal of anticoagulation is not directly related to a higher rate of ECMO circuit-related complications, but a prolonged duration of VV-ECMO support and polytransfusion might be. (5) Additional transarterial embolization to control postoperative bleeding may further improve outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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49. The w-iLab.t Testbed

Author

Bouckaert, Stefan, Vandenberghe, Wim, Jooris, Bart, Moerman, Ingrid, Demeester, Piet, Akan, Ozgur, Series editor, Bellavista, Paolo, Series editor, Cao, Jiannong, Series editor, Dressler, Falko, Series editor, Ferrari, Domenico, Series editor, Gerla, Mario, Series editor, Kobayashi, Hisashi, Series editor, Palazzo, Sergio, Series editor, Sahni, Sartaj, Series editor, Shen, Xuemin (Sherman), Series editor, Stan, Mircea, Series editor, Xiaohua, Jia, Series editor, Zomaya, Albert, Series editor, Coulson, Geoffrey, Series editor, Magedanz, Thomas, editor, Gavras, Anastasius, editor, Thanh, Nguyen Huu, editor, and Chase, Jeffry S., editor

Published
2011
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50. Performance Validation Strategies for 5G-enhanced Transport & Logistics: The 5G-Blueprint Approach

Author

Slamnik-Krijestorac, Nina, Vandenberghe, Wim, Kusumakar, Rakshith, Kural, Karel, Klepper, Matthijs, Kakes, Geerd, Vande Velde, Linde, and Marquez-Barja, Johann

Subjects
Mass communications, Engineering sciences. Technology
Abstract

A big challenge of autonomous mobility is guaranteeing safety in all possible extreme and unexpected scenarios. For the last 25 years, the sector therefore focused on improving the automation functions. Nevertheless, autonomous mobility is still not part of daily life. The 5G-Blueprint project follows an alternative approach: direct control teleoperation. This concept relies on 5G connectivity to remove the physical coupling between the human driver or sailor and the controlled vehicle or vessel. This way, automation and teleoperation can be combined as complementary technologies, assigning them to different segments of a single trajectory, realizing driverless mobility in a safe, scalable, and cost-efficient manner. However, this mode of operation brings demanding connectivity requirements, such as high uplink bandwidth, low latency and ultra-reliability at the same time, for which the potential of 5G needs to be studied and explored. In this paper, we present our performance validation strategies to pursue 5G-enhanced teleoperation in real-life environment (e.g., public roads, busy sea ports), including some initial results that we collected during the in-country piloting phase.

Published
2022
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