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1. The novel Mechanical Ventilator Milano for the COVID-19 pandemic

Author

Abba, A, Accorsi, C, Agnes, P, Alessi, E, Amaudruz, P, Annovi, A, Desages, F, Back, S, Badia, C, Bagger, J, Basile, V, Batignani, G, Bayo, A, Bell, B, Beschi, M, Biagini, D, Bianchi, G, Bicelli, S, Bishop, D, Boccali, T, Bombarda, A, Bonfanti, S, Bonivento, W, Bouchard, M, Breviario, M, Brice, S, Brown, R, Calvo-Mozota, J, Camozzi, L, Camozzi, M, Capra, A, Caravati, M, Carlini, M, Ceccanti, A, Celano, B, Cela Ruiz, J, Charette, C, Cogliati, G, Constable, M, Crippa, C, Croci, G, Cudmore, S, Dahl, C, Dal Molin, A, Daley, M, Di Guardo, C, D'Avenio, G, Davignon, O, Del Tutto, M, De Ruiter, J, Devoto, A, Diaz Gomez Maqueo, P, Di Francesco, F, Dossi, M, Druszkiewicz, E, Duma, C, Elliott, E, Farina, D, Fernandes, C, Ferroni, F, Finocchiaro, G, Fiorillo, G, Ford, R, Foti, G, Fournier, R, Franco, D, Fricbergs, C, Gabriele, F, Galbiati, C, Garcia Abia, P, Gargantini, A, Giacomelli, L, Giacomini, F, Giarratana, L, Gillespie, S, Giorgi, D, Girma, T, Gobui, R, Goeldi, D, Golf, F, Gorel, P, Gorini, G, Gramellini, E, Grosso, G, Guescini, F, Guetre, E, Hackman, G, Hadden, T, Hawkins, W, Hayashi, K, Heavey, A, Hersak, G, Hessey, N, Hockin, G, Hudson, K, Ianni, A, Ienzi, C, Ippolito, V, James, C, Jillings, C, Kendziora, C, Khan, S, Kim, E, King, M, King, S, Kittmer, A, Kochanek, I, Kowalkowski, J, Krucken, R, Kushoro, M, Kuula, S, Laclaustra, M, Leblond, G, Lee, L, Lennarz, A, Leyton, M, Li, X, Liimatainen, P, Lim, C, Lindner, T, Lomonaco, T, Lu, P, Lubna, R, Lukhanin, G, Luzon, G, Macdonald, M, Magni, G, Maharaj, R, Manni, S, Mapelli, C, Margetak, P, Martin, L, Martin, S, Martinez, M, Massacret, N, Mcclurg, P, Mcdonald, A, Meazzi, E, Migalla, R, Mohayai, T, Tosatti, L, Monzani, G, Moretti, C, Morrison, B, Mountaniol, M, Muraro, A, Napoli, P, Nati, F, Natzke, C, Noble, A, Norrick, A, Olchanski, K, Ortiz De Solorzano, A, Padula, F, Pallavicini, M, Palumbo, I, Panontin, E, Papini, N, Parmeggiano, L, Parmeggiano, S, Patel, K, Patel, A, Paterno, M, Pellegrino, C, Pelliccione, P, Pesudo, V, Pocar, A, Pope, A, Pordes, S, Prelz, F, Putignano, O, Raaf, J, Ratti, C, Razeti, M, Razeto, A, Reed, D, Refsgaard, J, Reilly, T, Renshaw, A, Retriere, F, Riccobene, E, Rigamonti, D, Rizzi, A, Rode, J, Romualdez, J, Russel, L, Sablone, D, Sala, S, Salomoni, D, Salvo, P, Sandoval, A, Sansoucy, E, Santorelli, R, Savarese, C, Scapparone, E, Schaubel, T, Scorza, S, Settimo, M, Shaw, B, Shawyer, S, Sher, A, Shi, A, Skensved, P, Slutsky, A, Smith, B, Smith, N, Stenzler, A, Straubel, C, Stringari, P, Suchenek, M, Sur, B, Tacchino, S, Takeuchi, L, Tardocchi, M, Tartaglia, R, Thomas, E, Trask, D, Tseng, J, Tseng, L, Vanpagee, L, Vedia, V, Velghe, B, Viel, S, Visioli, A, Viviani, L, Vonica, D, Wada, M, Walter, D, Wang, H, Wang, M, Westerdale, S, Wood, D, Yates, D, Yue, S, Zambrano, V, Abba A., Accorsi C., Agnes P., Alessi E., Amaudruz P., Annovi A., Desages F. A., Back S., Badia C., Bagger J., Basile V., Batignani G., Bayo A., Bell B., Beschi M., Biagini D., Bianchi G., Bicelli S., Bishop D., Boccali T., Bombarda A., Bonfanti S., Bonivento W. M., Bouchard M., Breviario M., Brice S., Brown R., Calvo-Mozota J. M., Camozzi L., Camozzi M., Capra A., Caravati M., Carlini M., Ceccanti A., Celano B., Cela Ruiz J. M., Charette C., Cogliati G., Constable M., Crippa C., Croci G., Cudmore S., Dahl C. E., Dal Molin A., Daley M., Di Guardo C., D'Avenio G., Davignon O., Del Tutto M., De Ruiter J., Devoto A., Diaz Gomez Maqueo P., Di Francesco F., Dossi M., Druszkiewicz E., Duma C., Elliott E., Farina D., Fernandes C., Ferroni F., Finocchiaro G., Fiorillo G., Ford R., Foti G., Fournier R. D., Franco D., Fricbergs C., Gabriele F., Galbiati C., Garcia Abia P., Gargantini A., Giacomelli L., Giacomini F., Giarratana L. S., Gillespie S., Giorgi D., Girma T., Gobui R., Goeldi D., Golf F., Gorel P., Gorini G., Gramellini E., Grosso G., Guescini F., Guetre E., Hackman G., Hadden T., Hawkins W., Hayashi K., Heavey A., Hersak G., Hessey N., Hockin G., Hudson K., Ianni A., Ienzi C., Ippolito V., James C. C., Jillings C., Kendziora C., Khan S., Kim E., King M., King S., Kittmer A., Kochanek I., Kowalkowski J., Krucken R., Kushoro M., Kuula S., Laclaustra M., Leblond G., Lee L., Lennarz A., Leyton M., Li X., Liimatainen P., Lim C., Lindner T., Lomonaco T., Lu P., Lubna R., Lukhanin G. A., Luzon G., Macdonald M., Magni G., Maharaj R., Manni S., Mapelli C., Margetak P., Martin L., Martin S., Martinez M., Massacret N., McClurg P., McDonald A. B., Meazzi E., Migalla R., Mohayai T., Tosatti L. M., Monzani G., Moretti C., Morrison B., Mountaniol M., Muraro A., Napoli P., Nati F., Natzke C. R., Noble A. J., Norrick A., Olchanski K., Ortiz De Solorzano A., Padula F., Pallavicini M., Palumbo I., Panontin E., Papini N., Parmeggiano L., Parmeggiano S., Patel K., Patel A., Paterno M., Pellegrino C., Pelliccione P., Pesudo V., Pocar A., Pope A., Pordes S., Prelz F., Putignano O., Raaf J. L., Ratti C., Razeti M., Razeto A., Reed D., Refsgaard J., Reilly T., Renshaw A., Retriere F., Riccobene E., Rigamonti D., Rizzi A., Rode J., Romualdez J., Russel L., Sablone D., Sala S., Salomoni D., Salvo P., Sandoval A., Sansoucy E., Santorelli R., Savarese C., Scapparone E., Schaubel T., Scorza S., Settimo M., Shaw B., Shawyer S., Sher A., Shi A., Skensved P., Slutsky A., Smith B., Smith N. J. T., Stenzler A., Straubel C., Stringari P., Suchenek M., Sur B., Tacchino S., Takeuchi L., Tardocchi M., Tartaglia R., Thomas E., Trask D., Tseng J., Tseng L., Vanpagee L., Vedia V., Velghe B., Viel S., Visioli A., Viviani L., Vonica D., Wada M., Walter D., Wang H., Wang M. H. L. S., Westerdale S., Wood D., Yates D., Yue S., Zambrano V., Abba, A, Accorsi, C, Agnes, P, Alessi, E, Amaudruz, P, Annovi, A, Desages, F, Back, S, Badia, C, Bagger, J, Basile, V, Batignani, G, Bayo, A, Bell, B, Beschi, M, Biagini, D, Bianchi, G, Bicelli, S, Bishop, D, Boccali, T, Bombarda, A, Bonfanti, S, Bonivento, W, Bouchard, M, Breviario, M, Brice, S, Brown, R, Calvo-Mozota, J, Camozzi, L, Camozzi, M, Capra, A, Caravati, M, Carlini, M, Ceccanti, A, Celano, B, Cela Ruiz, J, Charette, C, Cogliati, G, Constable, M, Crippa, C, Croci, G, Cudmore, S, Dahl, C, Dal Molin, A, Daley, M, Di Guardo, C, D'Avenio, G, Davignon, O, Del Tutto, M, De Ruiter, J, Devoto, A, Diaz Gomez Maqueo, P, Di Francesco, F, Dossi, M, Druszkiewicz, E, Duma, C, Elliott, E, Farina, D, Fernandes, C, Ferroni, F, Finocchiaro, G, Fiorillo, G, Ford, R, Foti, G, Fournier, R, Franco, D, Fricbergs, C, Gabriele, F, Galbiati, C, Garcia Abia, P, Gargantini, A, Giacomelli, L, Giacomini, F, Giarratana, L, Gillespie, S, Giorgi, D, Girma, T, Gobui, R, Goeldi, D, Golf, F, Gorel, P, Gorini, G, Gramellini, E, Grosso, G, Guescini, F, Guetre, E, Hackman, G, Hadden, T, Hawkins, W, Hayashi, K, Heavey, A, Hersak, G, Hessey, N, Hockin, G, Hudson, K, Ianni, A, Ienzi, C, Ippolito, V, James, C, Jillings, C, Kendziora, C, Khan, S, Kim, E, King, M, King, S, Kittmer, A, Kochanek, I, Kowalkowski, J, Krucken, R, Kushoro, M, Kuula, S, Laclaustra, M, Leblond, G, Lee, L, Lennarz, A, Leyton, M, Li, X, Liimatainen, P, Lim, C, Lindner, T, Lomonaco, T, Lu, P, Lubna, R, Lukhanin, G, Luzon, G, Macdonald, M, Magni, G, Maharaj, R, Manni, S, Mapelli, C, Margetak, P, Martin, L, Martin, S, Martinez, M, Massacret, N, Mcclurg, P, Mcdonald, A, Meazzi, E, Migalla, R, Mohayai, T, Tosatti, L, Monzani, G, Moretti, C, Morrison, B, Mountaniol, M, Muraro, A, Napoli, P, Nati, F, Natzke, C, Noble, A, Norrick, A, Olchanski, K, Ortiz De Solorzano, A, Padula, F, Pallavicini, M, Palumbo, I, Panontin, E, Papini, N, Parmeggiano, L, Parmeggiano, S, Patel, K, Patel, A, Paterno, M, Pellegrino, C, Pelliccione, P, Pesudo, V, Pocar, A, Pope, A, Pordes, S, Prelz, F, Putignano, O, Raaf, J, Ratti, C, Razeti, M, Razeto, A, Reed, D, Refsgaard, J, Reilly, T, Renshaw, A, Retriere, F, Riccobene, E, Rigamonti, D, Rizzi, A, Rode, J, Romualdez, J, Russel, L, Sablone, D, Sala, S, Salomoni, D, Salvo, P, Sandoval, A, Sansoucy, E, Santorelli, R, Savarese, C, Scapparone, E, Schaubel, T, Scorza, S, Settimo, M, Shaw, B, Shawyer, S, Sher, A, Shi, A, Skensved, P, Slutsky, A, Smith, B, Smith, N, Stenzler, A, Straubel, C, Stringari, P, Suchenek, M, Sur, B, Tacchino, S, Takeuchi, L, Tardocchi, M, Tartaglia, R, Thomas, E, Trask, D, Tseng, J, Tseng, L, Vanpagee, L, Vedia, V, Velghe, B, Viel, S, Visioli, A, Viviani, L, Vonica, D, Wada, M, Walter, D, Wang, H, Wang, M, Westerdale, S, Wood, D, Yates, D, Yue, S, Zambrano, V, Abba A., Accorsi C., Agnes P., Alessi E., Amaudruz P., Annovi A., Desages F. A., Back S., Badia C., Bagger J., Basile V., Batignani G., Bayo A., Bell B., Beschi M., Biagini D., Bianchi G., Bicelli S., Bishop D., Boccali T., Bombarda A., Bonfanti S., Bonivento W. M., Bouchard M., Breviario M., Brice S., Brown R., Calvo-Mozota J. M., Camozzi L., Camozzi M., Capra A., Caravati M., Carlini M., Ceccanti A., Celano B., Cela Ruiz J. M., Charette C., Cogliati G., Constable M., Crippa C., Croci G., Cudmore S., Dahl C. E., Dal Molin A., Daley M., Di Guardo C., D'Avenio G., Davignon O., Del Tutto M., De Ruiter J., Devoto A., Diaz Gomez Maqueo P., Di Francesco F., Dossi M., Druszkiewicz E., Duma C., Elliott E., Farina D., Fernandes C., Ferroni F., Finocchiaro G., Fiorillo G., Ford R., Foti G., Fournier R. D., Franco D., Fricbergs C., Gabriele F., Galbiati C., Garcia Abia P., Gargantini A., Giacomelli L., Giacomini F., Giarratana L. S., Gillespie S., Giorgi D., Girma T., Gobui R., Goeldi D., Golf F., Gorel P., Gorini G., Gramellini E., Grosso G., Guescini F., Guetre E., Hackman G., Hadden T., Hawkins W., Hayashi K., Heavey A., Hersak G., Hessey N., Hockin G., Hudson K., Ianni A., Ienzi C., Ippolito V., James C. C., Jillings C., Kendziora C., Khan S., Kim E., King M., King S., Kittmer A., Kochanek I., Kowalkowski J., Krucken R., Kushoro M., Kuula S., Laclaustra M., Leblond G., Lee L., Lennarz A., Leyton M., Li X., Liimatainen P., Lim C., Lindner T., Lomonaco T., Lu P., Lubna R., Lukhanin G. A., Luzon G., Macdonald M., Magni G., Maharaj R., Manni S., Mapelli C., Margetak P., Martin L., Martin S., Martinez M., Massacret N., McClurg P., McDonald A. B., Meazzi E., Migalla R., Mohayai T., Tosatti L. M., Monzani G., Moretti C., Morrison B., Mountaniol M., Muraro A., Napoli P., Nati F., Natzke C. R., Noble A. J., Norrick A., Olchanski K., Ortiz De Solorzano A., Padula F., Pallavicini M., Palumbo I., Panontin E., Papini N., Parmeggiano L., Parmeggiano S., Patel K., Patel A., Paterno M., Pellegrino C., Pelliccione P., Pesudo V., Pocar A., Pope A., Pordes S., Prelz F., Putignano O., Raaf J. L., Ratti C., Razeti M., Razeto A., Reed D., Refsgaard J., Reilly T., Renshaw A., Retriere F., Riccobene E., Rigamonti D., Rizzi A., Rode J., Romualdez J., Russel L., Sablone D., Sala S., Salomoni D., Salvo P., Sandoval A., Sansoucy E., Santorelli R., Savarese C., Scapparone E., Schaubel T., Scorza S., Settimo M., Shaw B., Shawyer S., Sher A., Shi A., Skensved P., Slutsky A., Smith B., Smith N. J. T., Stenzler A., Straubel C., Stringari P., Suchenek M., Sur B., Tacchino S., Takeuchi L., Tardocchi M., Tartaglia R., Thomas E., Trask D., Tseng J., Tseng L., Vanpagee L., Vedia V., Velghe B., Viel S., Visioli A., Viviani L., Vonica D., Wada M., Walter D., Wang H., Wang M. H. L. S., Westerdale S., Wood D., Yates D., Yue S., and Zambrano V.

Abstract

This paper presents the Mechanical Ventilator Milano (MVM), a novel intensive therapy mechanical ventilator designed for rapid, large-scale, low-cost production for the COVID-19 pandemic. Free of moving mechanical parts and requiring only a source of compressed oxygen and medical air to operate, the MVM is designed to support the long-term invasive ventilation often required for COVID-19 patients and operates in pressure-regulated ventilation modes, which minimize the risk of furthering lung trauma. The MVM was extensively tested against ISO standards in the laboratory using a breathing simulator, with good agreement between input and measured breathing parameters and performing correctly in response to fault conditions and stability tests. The MVM has obtained Emergency Use Authorization by U.S. Food and Drug Administration (FDA) for use in healthcare settings during the COVID-19 pandemic and Health Canada Medical Device Authorization for Importation or Sale, under Interim Order for Use in Relation to COVID-19. Following these certifications, mass production is ongoing and distribution is under way in several countries. The MVM was designed, tested, prepared for certification, and mass produced in the space of a few months by a unique collaboration of respiratory healthcare professionals and experimental physicists, working with industrial partners, and is an excellent ventilator candidate for this pandemic anywhere in the world.

Published
2021

2. The novel Mechanical Ventilator Milano for the COVID-19 pandemic

Author

Abba, A., primary, Accorsi, C., additional, Agnes, P., additional, Alessi, E., additional, Amaudruz, P., additional, Annovi, A., additional, Desages, F. Ardellier, additional, Back, S., additional, Badia, C., additional, Bagger, J., additional, Basile, V., additional, Batignani, G., additional, Bayo, A., additional, Bell, B., additional, Beschi, M., additional, Biagini, D., additional, Bianchi, G., additional, Bicelli, S., additional, Bishop, D., additional, Boccali, T., additional, Bombarda, A., additional, Bonfanti, S., additional, Bonivento, W. M., additional, Bouchard, M., additional, Breviario, M., additional, Brice, S., additional, Brown, R., additional, Calvo-Mozota, J. M., additional, Camozzi, L., additional, Camozzi, M., additional, Capra, A., additional, Caravati, M., additional, Carlini, M., additional, Ceccanti, A., additional, Celano, B., additional, Cela Ruiz, J. M., additional, Charette, C., additional, Cogliati, G., additional, Constable, M., additional, Crippa, C., additional, Croci, G., additional, Cudmore, S., additional, Dahl, C. E., additional, Dal Molin, A., additional, Daley, M., additional, Di Guardo, C., additional, D'Avenio, G., additional, Davignon, O., additional, Del Tutto, M., additional, De Ruiter, J., additional, Devoto, A., additional, Diaz Gomez Maqueo, P., additional, Di Francesco, F., additional, Dossi, M., additional, Druszkiewicz, E., additional, Duma, C., additional, Elliott, E., additional, Farina, D., additional, Fernandes, C., additional, Ferroni, F., additional, Finocchiaro, G., additional, Fiorillo, G., additional, Ford, R., additional, Foti, G., additional, Fournier, R. D., additional, Franco, D., additional, Fricbergs, C., additional, Gabriele, F., additional, Galbiati, C., additional, Garcia Abia, P., additional, Gargantini, A., additional, Giacomelli, L., additional, Giacomini, F., additional, Giarratana, L. S., additional, Gillespie, S., additional, Giorgi, D., additional, Girma, T., additional, Gobui, R., additional, Goeldi, D., additional, Golf, F., additional, Gorel, P., additional, Gorini, G., additional, Gramellini, E., additional, Grosso, G., additional, Guescini, F., additional, Guetre, E., additional, Hackman, G., additional, Hadden, T., additional, Hawkins, W., additional, Hayashi, K., additional, Heavey, A., additional, Hersak, G., additional, Hessey, N., additional, Hockin, G., additional, Hudson, K., additional, Ianni, A., additional, Ienzi, C., additional, Ippolito, V., additional, James, C. C., additional, Jillings, C., additional, Kendziora, C., additional, Khan, S., additional, Kim, E., additional, King, M., additional, King, S., additional, Kittmer, A., additional, Kochanek, I., additional, Kowalkowski, J., additional, Krücken, R., additional, Kushoro, M., additional, Kuula, S., additional, Laclaustra, M., additional, Leblond, G., additional, Lee, L., additional, Lennarz, A., additional, Leyton, M., additional, Li, X., additional, Liimatainen, P., additional, Lim, C., additional, Lindner, T., additional, Lomonaco, T., additional, Lu, P., additional, Lubna, R., additional, Lukhanin, G. A., additional, Luzón, G., additional, MacDonald, M., additional, Magni, G., additional, Maharaj, R., additional, Manni, S., additional, Mapelli, C., additional, Margetak, P., additional, Martin, L., additional, Martin, S., additional, Martínez, M., additional, Massacret, N., additional, McClurg, P., additional, McDonald, A. B., additional, Meazzi, E., additional, Migalla, R., additional, Mohayai, T., additional, Tosatti, L. M., additional, Monzani, G., additional, Moretti, C., additional, Morrison, B., additional, Mountaniol, M., additional, Muraro, A., additional, Napoli, P., additional, Nati, F., additional, Natzke, C. R., additional, Noble, A. J., additional, Norrick, A., additional, Olchanski, K., additional, Ortiz de Solorzano, A., additional, Padula, F., additional, Pallavicini, M., additional, Palumbo, I., additional, Panontin, E., additional, Papini, N., additional, Parmeggiano, L., additional, Parmeggiano, S., additional, Patel, K., additional, Patel, A., additional, Paterno, M., additional, Pellegrino, C., additional, Pelliccione, P., additional, Pesudo, V., additional, Pocar, A., additional, Pope, A., additional, Pordes, S., additional, Prelz, F., additional, Putignano, O., additional, Raaf, J. L., additional, Ratti, C., additional, Razeti, M., additional, Razeto, A., additional, Reed, D., additional, Refsgaard, J., additional, Reilly, T., additional, Renshaw, A., additional, Retriere, F., additional, Riccobene, E., additional, Rigamonti, D., additional, Rizzi, A., additional, Rode, J., additional, Romualdez, J., additional, Russel, L., additional, Sablone, D., additional, Sala, S., additional, Salomoni, D., additional, Salvo, P., additional, Sandoval, A., additional, Sansoucy, E., additional, Santorelli, R., additional, Savarese, C., additional, Scapparone, E., additional, Schaubel, T., additional, Scorza, S., additional, Settimo, M., additional, Shaw, B., additional, Shawyer, S., additional, Sher, A., additional, Shi, A., additional, Skensved, P., additional, Slutsky, A., additional, Smith, B., additional, Smith, N. J. T., additional, Stenzler, A., additional, Straubel, C., additional, Stringari, P., additional, Suchenek, M., additional, Sur, B., additional, Tacchino, S., additional, Takeuchi, L., additional, Tardocchi, M., additional, Tartaglia, R., additional, Thomas, E., additional, Trask, D., additional, Tseng, J., additional, Tseng, L., additional, VanPagee, L., additional, Vedia, V., additional, Velghe, B., additional, Viel, S., additional, Visioli, A., additional, Viviani, L., additional, Vonica, D., additional, Wada, M., additional, Walter, D., additional, Wang, H., additional, Wang, M. H. L. S., additional, Westerdale, S., additional, Wood, D., additional, Yates, D., additional, Yue, S., additional, and Zambrano, V., additional

Published
2021
Full Text
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3. The novel Mechanical Ventilator Milano for the COVID-19 pandemic

Author

M. Tardocchi, P. Lu, Silvia Bonfanti, C. Fricbergs, J. M. Cela Ruiz, M. Del Tutto, R. Brown, D. Salomoni, C. Jillings, A. Visioli, A. Abba, B. Smith, P. Stringari, Valerio Ippolito, K. Olchanski, S. Yue, A. Razeto, L. Parmeggiano, M. Beschi, I. Palumbo, C. C. James, M. Daley, Andrea Bombarda, Eugenio Scapparone, T. Boccali, D. Vonica, G. Luzón, E. Panontin, Nigel Hessey, E. Elliott, O. Putignano, R. Maharaj, M. H. L. S. Wang, M. Laclaustra, A. Sher, E. Gramellini, P. Napoli, S. Parmeggiano, E. Meazzi, S. Sala, A. Muraro, T. Girma, D. Trask, A. Lennarz, F. Golf, G. Magni, C. Di Guardo, A. S. Slutsky, C. Lim, B. Shaw, C. Duma, V. Pesudo, S. Gillespie, A. Devoto, E. Guetre, L. Camozzi, B. Bell, C. E. Dahl, M. Dossi, E. Alessi, M. MacDonald, A. J. Noble, F. Ardellier Desages, O. Davignon, B. Morrison, R. D. Fournier, Alberto Annovi, S. Kuula, Elvinia Riccobene, A. Rizzi, G. Hersak, J. Bagger, S. Brice, S. Khan, L. VanPagee, P. Salvo, R. Lubna, A. Bayo, M. Bouchard, J. Romualdez, G. Bianchi, H. Wang, S. Bicelli, T. A. Mohayai, A. Dal Molin, M. Breviario, C. Ienzi, M. Carlini, K. Hayashi, G. Monzani, G. A. Lukhanin, R. J. Ford, D. Yates, B. Velghe, G. Finocchiaro, C. Charette, M.H. Kushoro, E. Sansoucy, D. Reed, Pierre-Andre Amaudruz, A. Pocar, S. Scorza, M. Camozzi, T. Reilly, C. Crippa, S. Pordes, F. Padula, S. Westerdale, C. Straubel, P. Garcia Abia, A. Shi, D. Giorgi, A. Capra, S. Shawyer, S. Martin, F. Prelz, S. Back, D. Sablone, L. Takeuchi, D. Franco, L. Martin, An. Ianni, L. Tseng, P. McClurg, M. I. Martínez, D. Wood, A. Norrick, C. Pellegrino, J. Tseng, C. Ratti, M. Constable, V. Vedia, L. M. Tosatti, L. S. Giarratana, G. Fiorillo, M. Razeti, A. Patel, C. R. Natzke, S. Manni, M. Wada, S. Tacchino, M. Paterno, P. Gorel, P. Diaz Gomez Maqueo, N. Massacret, S. Cudmore, Marco Pallavicini, A. Heavey, Gabriele Croci, E. Kim, B. Celano, G. Batignani, E. Druszkiewicz, A. L. Renshaw, L. Giacomelli, D. Walter, S. Viel, Angelo Gargantini, D. Goeldi, P. Liimatainen, N. J. T. Smith, T. Schaubel, G. Cogliati, G. Foti, C. Mapelli, F. Retriere, Giuseppe Gorini, K. Patel, R. Tartaglia, N. Papini, M. Settimo, P. Pelliccione, P. Skensved, M. Leyton, V. Basile, A. Kittmer, G. D'Avenio, D. Rigamonti, R. Krücken, F. Guescini, F. Giacomini, E. Thomas, K. Hudson, Claudio Moretti, R. Santorelli, G. Hackman, R. Gobui, L. Viviani, C. Savarese, I. Kochanek, R. Migalla, J. Rode, F. Gabriele, D. Farina, F. Ferroni, F. Di Francesco, J. M. Calvo-Mozota, M. Suchenek, G. Hockin, J. Refsgaard, J. Kowalkowski, A. Pope, T. Lomonaco, S. King, Bhaskar Sur, C. L. Kendziora, M. Caravati, A. Ceccanti, W. Hawkins, W. Bonivento, C. Fernandes, G. Leblond, M. Mountaniol, A. B. McDonald, C. Accorsi, A. Stenzler, Federico Nati, V. Zambrano, D. Bishop, M. King, A. Sandoval, X. Li, P. Margetak, P. Agnes, J. L. Raaf, J. De Ruiter, Cristiano Galbiati, Giovanni Grosso, L. Lee, A. Ortiz de Solórzano, T. Hadden, T. Lindner, D. Biagini, L. Russel, C. Badia, Abba, A., Accorsi, C., Agnes, P., Alessi, E., Amaudruz, P., Annovi, A., Desages, F. A., Back, S., Badia, C., Bagger, J., Basile, V., Batignani, G., Bayo, A., Bell, B., Beschi, M., Biagini, D., Bianchi, G., Bicelli, S., Bishop, D., Boccali, T., Bombarda, A., Bonfanti, S., Bonivento, W. M., Bouchard, M., Breviario, M., Brice, S., Brown, R., Calvo-Mozota, J. M., Camozzi, L., Camozzi, M., Capra, A., Caravati, M., Carlini, M., Ceccanti, A., Celano, B., Cela Ruiz, J. M., Charette, C., Cogliati, G., Constable, M., Crippa, C., Croci, G., Cudmore, S., Dahl, C. E., Dal Molin, A., Daley, M., Di Guardo, C., D'Avenio, G., Davignon, O., Del Tutto, M., De Ruiter, J., Devoto, A., Diaz Gomez Maqueo, P., Di Francesco, F., Dossi, M., Druszkiewicz, E., Duma, C., Elliott, E., Farina, D., Fernandes, C., Ferroni, F., Finocchiaro, G., Fiorillo, G., Ford, R., Foti, G., Fournier, R. D., Franco, D., Fricbergs, C., Gabriele, F., Galbiati, C., Garcia Abia, P., Gargantini, A., Giacomelli, L., Giacomini, F., Giarratana, L. S., Gillespie, S., Giorgi, D., Girma, T., Gobui, R., Goeldi, D., Golf, F., Gorel, P., Gorini, G., Gramellini, E., Grosso, G., Guescini, F., Guetre, E., Hackman, G., Hadden, T., Hawkins, W., Hayashi, K., Heavey, A., Hersak, G., Hessey, N., Hockin, G., Hudson, K., Ianni, A., Ienzi, C., Ippolito, V., James, C. C., Jillings, C., Kendziora, C., Khan, S., Kim, E., King, M., King, S., Kittmer, A., Kochanek, I., Kowalkowski, J., Krucken, R., Kushoro, M., Kuula, S., Laclaustra, M., Leblond, G., Lee, L., Lennarz, A., Leyton, M., Li, X., Liimatainen, P., Lim, C., Lindner, T., Lomonaco, T., Lu, P., Lubna, R., Lukhanin, G. A., Luzon, G., Macdonald, M., Magni, G., Maharaj, R., Manni, S., Mapelli, C., Margetak, P., Martin, L., Martin, S., Martinez, M., Massacret, N., Mcclurg, P., Mcdonald, A. B., Meazzi, E., Migalla, R., Mohayai, T., Tosatti, L. M., Monzani, G., Moretti, C., Morrison, B., Mountaniol, M., Muraro, A., Napoli, P., Nati, F., Natzke, C. R., Noble, A. J., Norrick, A., Olchanski, K., Ortiz De Solorzano, A., Padula, F., Pallavicini, M., Palumbo, I., Panontin, E., Papini, N., Parmeggiano, L., Parmeggiano, S., Patel, K., Patel, A., Paterno, M., Pellegrino, C., Pelliccione, P., Pesudo, V., Pocar, A., Pope, A., Pordes, S., Prelz, F., Putignano, O., Raaf, J. L., Ratti, C., Razeti, M., Razeto, A., Reed, D., Refsgaard, J., Reilly, T., Renshaw, A., Retriere, F., Riccobene, E., Rigamonti, D., Rizzi, A., Rode, J., Romualdez, J., Russel, L., Sablone, D., Sala, S., Salomoni, D., Salvo, P., Sandoval, A., Sansoucy, E., Santorelli, R., Savarese, C., Scapparone, E., Schaubel, T., Scorza, S., Settimo, M., Shaw, B., Shawyer, S., Sher, A., Shi, A., Skensved, P., Slutsky, A., Smith, B., Smith, N. J. T., Stenzler, A., Straubel, C., Stringari, P., Suchenek, M., Sur, B., Tacchino, S., Takeuchi, L., Tardocchi, M., Tartaglia, R., Thomas, E., Trask, D., Tseng, J., Tseng, L., Vanpagee, L., Vedia, V., Velghe, B., Viel, S., Visioli, A., Viviani, L., Vonica, D., Wada, M., Walter, D., Wang, H., Wang, M. H. L. S., Westerdale, S., Wood, D., Yates, D., Yue, S., Zambrano, V., AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), École des Mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Abba, A, Accorsi, C, Agnes, P, Alessi, E, Amaudruz, P, Annovi, A, Desages, F, Back, S, Badia, C, Bagger, J, Basile, V, Batignani, G, Bayo, A, Bell, B, Beschi, M, Biagini, D, Bianchi, G, Bicelli, S, Bishop, D, Boccali, T, Bombarda, A, Bonfanti, S, Bonivento, W, Bouchard, M, Breviario, M, Brice, S, Brown, R, Calvo-Mozota, J, Camozzi, L, Camozzi, M, Capra, A, Caravati, M, Carlini, M, Ceccanti, A, Celano, B, Cela Ruiz, J, Charette, C, Cogliati, G, Constable, M, Crippa, C, Croci, G, Cudmore, S, Dahl, C, Dal Molin, A, Daley, M, Di Guardo, C, D'Avenio, G, Davignon, O, Del Tutto, M, De Ruiter, J, Devoto, A, Diaz Gomez Maqueo, P, Di Francesco, F, Dossi, M, Druszkiewicz, E, Duma, C, Elliott, E, Farina, D, Fernandes, C, Ferroni, F, Finocchiaro, G, Fiorillo, G, Ford, R, Foti, G, Fournier, R, Franco, D, Fricbergs, C, Gabriele, F, Galbiati, C, Garcia Abia, P, Gargantini, A, Giacomelli, L, Giacomini, F, Giarratana, L, Gillespie, S, Giorgi, D, Girma, T, Gobui, R, Goeldi, D, Golf, F, Gorel, P, Gorini, G, Gramellini, E, Grosso, G, Guescini, F, Guetre, E, Hackman, G, Hadden, T, Hawkins, W, Hayashi, K, Heavey, A, Hersak, G, Hessey, N, Hockin, G, Hudson, K, Ianni, A, Ienzi, C, Ippolito, V, James, C, Jillings, C, Kendziora, C, Khan, S, Kim, E, King, M, King, S, Kittmer, A, Kochanek, I, Kowalkowski, J, Krucken, R, Kushoro, M, Kuula, S, Laclaustra, M, Leblond, G, Lee, L, Lennarz, A, Leyton, M, Li, X, Liimatainen, P, Lim, C, Lindner, T, Lomonaco, T, Lu, P, Lubna, R, Lukhanin, G, Luzon, G, Macdonald, M, Magni, G, Maharaj, R, Manni, S, Mapelli, C, Margetak, P, Martin, L, Martin, S, Martinez, M, Massacret, N, Mcclurg, P, Mcdonald, A, Meazzi, E, Migalla, R, Mohayai, T, Tosatti, L, Monzani, G, Moretti, C, Morrison, B, Mountaniol, M, Muraro, A, Napoli, P, Nati, F, Natzke, C, Noble, A, Norrick, A, Olchanski, K, Ortiz De Solorzano, A, Padula, F, Pallavicini, M, Palumbo, I, Panontin, E, Papini, N, Parmeggiano, L, Parmeggiano, S, Patel, K, Patel, A, Paterno, M, Pellegrino, C, Pelliccione, P, Pesudo, V, Pocar, A, Pope, A, Pordes, S, Prelz, F, Putignano, O, Raaf, J, Ratti, C, Razeti, M, Razeto, A, Reed, D, Refsgaard, J, Reilly, T, Renshaw, A, Retriere, F, Riccobene, E, Rigamonti, D, Rizzi, A, Rode, J, Romualdez, J, Russel, L, Sablone, D, Sala, S, Salomoni, D, Salvo, P, Sandoval, A, Sansoucy, E, Santorelli, R, Savarese, C, Scapparone, E, Schaubel, T, Scorza, S, Settimo, M, Shaw, B, Shawyer, S, Sher, A, Shi, A, Skensved, P, Slutsky, A, Smith, B, Smith, N, Stenzler, A, Straubel, C, Stringari, P, Suchenek, M, Sur, B, Tacchino, S, Takeuchi, L, Tardocchi, M, Tartaglia, R, Thomas, E, Trask, D, Tseng, J, Tseng, L, Vanpagee, L, Vedia, V, Velghe, B, Viel, S, Visioli, A, Viviani, L, Vonica, D, Wada, M, Walter, D, Wang, H, Wang, M, Westerdale, S, Wood, D, Yates, D, Yue, S, and Zambrano, V

Subjects
ventilator, Emergency Use Authorization, Coronavirus disease 2019 (COVID-19), Fault conditions, Computational Mechanics, Certification, 01 natural sciences, 010305 fluids & plasmas, law.invention, Mechanical parts, Food and drug administration, Compressed oxygen, Food and Drug Administration, Health care professionals, Industrial partners, Intensive therapy, Ventilation mode, Mechanical ventilator, law, 0103 physical sciences, Pandemic, medicine, 010306 general physics, Fluid Flow and Transfer Processes, Physics, [PHYS]Physics [physics], Mechanical Engineering, healthcare, Articles, Condensed Matter Physics, medicine.disease, 3. Good health, Medical gas supply, Mechanical Ventilation, COVID-19 Pandemic, covid-19, Mechanics of Materials, Others, Ventilation (architecture), Medical emergency, Settore ING-INF/05 - Sistemi di Elaborazione delle Informazioni, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract

International audience; This paper presents the Mechanical Ventilator Milano (MVM), a novel intensive therapy mechanical ventilator designed for rapid, large-scale, low-cost production for the COVID-19 pandemic. Free of moving mechanical parts and requiring only a source of compressed oxygen and medical air to operate, the MVM is designed to support the long-term invasive ventilation often required for COVID-19 patients and operates in pressure-regulated ventilation modes, which minimize the risk of furthering lung trauma. The MVM was extensively tested against ISO standards in the laboratory using a breathing simulator, with good agreement between input and measured breathing parameters and performing correctly in response to fault conditions and stability tests. The MVM has obtained Emergency Use Authorization by U.S. Food and Drug Administration (FDA) for use in healthcare settings during the COVID-19 pandemic and Health Canada Medical Device Authorization for Importation or Sale, under Interim Order for Use in Relation to COVID-19. Following these certifications, mass production is ongoing and distribution is under way in several countries. The MVM was designed, tested, prepared for certification, and mass produced in the space of a few months by a unique collaboration of respiratory healthcare professionals and experimental physicists, working with industrial partners, and is an excellent ventilator candidate for this pandemic anywhere in the world

Published
2021

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