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Highlights from the Science family of journals.

Highlights from the Science family of journals.

Cytoplasmic condensates that mimic nuclear pore complexes entice viruses away from the nucleus.

Highlights from the Science family of journals.

The taurine metabolite N -acetyltaurine protects mice from diet-induced obesity by reducing food intake.

Highlights from the Science family of journals.

Highlights from the Science family of journals.

Antibiotic-induced loss of intestinal hypoxia boosts the growth of C. albicans in mice.

Highlights from the Science family of journals.

The orphan nuclear receptor ERRγ directs the differentiation of acid-secreting gastric cells.

Highlights from the Science family of journals.

Bacterial LPS disrupts the blood-brain barrier by inducing endothelial cell pyroptosis.

Displacement of the glycocalyx by membrane blebbing enables macrophages to recognize apoptotic cells.

Highlights from the Science family of journals.

The extracellular WNT-binding proteins SFRP and WIF1 promote and inhibit WNT signaling.

Highlights from the Science family of journals.

A Mycobacterium tuberculosis virulence factor promotes foam cell formation by inhibiting DNA repair.

Apoptotic cells that cannot be expelled from the epithelium provoke inflammation by releasing ATP.

Highlights from the Science family of journals.

Intestinal injury induces the outgrowth of adrenergic neurons that stimulate a proregenerative pathway.

Highlights from the Science family of journals.

Asymmetric movement of a polycystin subunit may underlie the initial break in left-right asymmetry in mouse embryos.

Highlights from the Science family of journals.

Senescent cells in naked mole-rats are eliminated by apoptosis.

Highlights from the Science family of journals.

Host reactive nitrogen species maintain intracellular Salmonella in an antibiotic-tolerant, persister state.

Highlights from the Science family of journals.

JMJD8 inhibits STING signaling and reduces antitumor responses.

Highlights from the Science family of journals.

Autophagy augments the mucus-secreting capacity of goblet cells by reducing ER stress.

Injury-induced hepatocyte reprogramming depends on a proinflammatory cytokine from Kupffer cells.

A fungal surface protein elicits grooming in flies.

Highlights from the Science family of journals.

Toxoplasma gondii infection confers a migratory phenotype upon macrophages.

A bacterial endopeptidase that generates NOD2 ligands suppresses colitis.

Highlights from the Science family of journals.

Resident macrophages mediate antigen capture and presentation in allergic airway inflammation in mice.

Plants detect and respond to neighbors with root-produced hormones.

The brine shrimp, Artemia franciscana, has a body plan composed of 11 thoracic segments, followed by 2 genital segments, and then 6 additional abdominal segments. Previous studies of Artemia reported that expression of the posterior-most Hox gene, Abdominal-B (Abd-B), is restricted to the genital segments and is not observed posteriorly in the abdomen at any developmental stage. This report was remarkable because it suggested that the Artemia abdomen posterior to the genital segments was a novel body region of 6 segments that bore no homology to any region in other crustaceans and was unique amongst arthropods in being a Hox-free segmented domain outside of the head. In this study, we used RT-PCR, antibody staining, and in situ hybridization on various stages of Artemia nauplii to show that Abd-B mRNA and protein are in fact expressed throughout the abdominal segments during Artemia development, but this expression later retracts to the two genital segments (G1, G2) and the T11 appendages. This suggests that Abd-B does play a role in specifying abdominal segment identity in all crustaceans that have been examined and suggests a common evolutionary origin for the crustacean abdomen., Competing Interests: Declaration of competing interest None., (Copyright © 2022 Elsevier Inc. All rights reserved.)

Bacterial stress caused by antibiotics increases a second messenger that directly stimulates host inflammation.

Highlights from the Science family of journals.

Highlights from the Science family of journals.

Sphingolipids from commensal bacteria transit to the liver and normalize lipid accumulation in a mouse model of hepatic steatosis.

A bacterial metabolite promotes the progression of colorectal cancer.

Increased neuropeptidergic signaling underlies lung dysfunction in a rare pediatric disease and may contribute to ARDS.

Highlights from the Science family of journals.

The restriction of the yeast prion-like protein Whi3 to particular regions of the ER prevents its transmission to daughter cells.

Highlights from the Science family of journals.

A Legionella virulence factor blocks mitochondrial ADP/ATP exchange in infected cells.