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4. Safety and Tolerability of Online Adaptive High-Field Magnetic Resonance–Guided Radiotherapy

Author

Westerhoff, Jasmijn M., primary, Daamen, Lois A., additional, Christodouleas, John P., additional, Blezer, Erwin L. A., additional, Choudhury, Ananya, additional, Westley, Rosalyne L., additional, Erickson, Beth A., additional, Fuller, Clifton D., additional, Hafeez, Shaista, additional, van der Heide, Uulke A., additional, Intven, Martijn P. W., additional, Kirby, Anna M., additional, Lalondrelle, Susan, additional, Minsky, Bruce D., additional, Mook, Stella, additional, Nowee, Marlies E., additional, Marijnen, Corrie A. M., additional, Orrling, Kristina M., additional, Sahgal, Arjun, additional, Schultz, Christopher J., additional, Faivre-Finn, Corinne, additional, Tersteeg, Robbert J. H. A., additional, Tree, Alison C., additional, Tseng, Chia-Lin, additional, Schytte, Tine, additional, Silk, Dustin M., additional, Eggert, Dave, additional, Luzzara, Marco, additional, van der Voort van Zyp, Jochem R. N., additional, Verkooijen, Helena M., additional, and Hall, William A., additional

Published
2024
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5. Conventional radical versus focal treatment for localised prostate cancer: a propensity score weighted comparison of 6-year tumour control

Author

van Son, Marieke J., Peters, Max, Reddy, Deepika, Shah, Taimur T., Hosking-Jervis, Feargus, Robinson, Stephen, Lagendijk, Jan J. W., Mangar, Stephen, Dudderidge, Tim, McCracken, Stuart, Hindley, Richard G., Emara, Amr, Nigam, Raj, Persad, Raj, Virdi, Jaspal, Lewi, Henry, Moore, Caroline, Orczyk, Clement, Emberton, Mark, Arya, Manit, Ahmed, Hashim U., van der Voort van Zyp, Jochem R. N., Winkler, Matt, and Falconer, Alison

Published
2021
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6. Deep-learning-based joint rigid and deformable contour propagation for magnetic resonance imaging-guided prostate radiotherapy

Author

Computational Imaging, Radiotherapie, MS Radiotherapie, Cancer, Kolenbrander, Iris D, Maspero, Matteo, Hendriksen, Allard A, Pollitt, Ryan, van der Voort van Zyp, Jochem R N, van den Berg, Cornelis A T, Pluim, Josien P W, van Eijnatten, Maureen A J M, Computational Imaging, Radiotherapie, MS Radiotherapie, Cancer, Kolenbrander, Iris D, Maspero, Matteo, Hendriksen, Allard A, Pollitt, Ryan, van der Voort van Zyp, Jochem R N, van den Berg, Cornelis A T, Pluim, Josien P W, and van Eijnatten, Maureen A J M

Published
2024

7. MRI-guided radiotherapy in twenty fractions for localised prostate cancer: results from the MOMENTUM study

Author

MS CGO, Cancer, Trialbureau Beeld, MS Radiotherapie, Sritharan, Kobika, Daamen, Lois, Pathmanathan, Angela, Schytte, Tine, Pos, Floris, Choudhury, Ananya, van der Voort van Zyp, Jochem R N, Kerkmeijer, Linda G W, Hall, William, Hall, Emma, Verkooijen, Helena M, Herbert, Trina, Hafeez, Shaista, Mitchell, Adam, Tree, Alison C, MS CGO, Cancer, Trialbureau Beeld, MS Radiotherapie, Sritharan, Kobika, Daamen, Lois, Pathmanathan, Angela, Schytte, Tine, Pos, Floris, Choudhury, Ananya, van der Voort van Zyp, Jochem R N, Kerkmeijer, Linda G W, Hall, William, Hall, Emma, Verkooijen, Helena M, Herbert, Trina, Hafeez, Shaista, Mitchell, Adam, and Tree, Alison C

Published
2024

8. Automated pelvic MRI measurements associated with urinary incontinence for prostate cancer patients undergoing radical prostatectomy

Author

Computational Imaging, MS Radiologie, MS Radiotherapie, Cancer, van den Berg, Ingeborg, Spaans, Robert N, Wessels, Frank J, van der Hoeven, Erik J R J, Nolthenius, Charlotte J Tutein, van den Bergh, Roderick C N, van der Voort van Zyp, Jochem R N, van den Berg, Cornelis A T, van Melick, Harm H E, Computational Imaging, MS Radiologie, MS Radiotherapie, Cancer, van den Berg, Ingeborg, Spaans, Robert N, Wessels, Frank J, van der Hoeven, Erik J R J, Nolthenius, Charlotte J Tutein, van den Bergh, Roderick C N, van der Voort van Zyp, Jochem R N, van den Berg, Cornelis A T, and van Melick, Harm H E

Published
2024

10. Deep‐learning‐based joint rigid and deformable contour propagation for magnetic resonance imaging‐guided prostate radiotherapy.

Author

Kolenbrander, Iris D., Maspero, Matteo, Hendriksen, Allard A., Pollitt, Ryan, van der Voort van Zyp, Jochem R. N., van den Berg, Cornelis A. T., Pluim, Josien P. W., and van Eijnatten, Maureen A. J. M.

Subjects
DEEP learning, MAGNETIC resonance, CONVOLUTIONAL neural networks, PROSTATE, PROSTATE cancer patients, IMAGE registration
Abstract

Background: Deep learning‐based unsupervised image registration has recently been proposed, promising fast registration. However, it has yet to be adopted in the online adaptive magnetic resonance imaging‐guided radiotherapy (MRgRT) workflow. Purpose: In this paper, we design an unsupervised, joint rigid, and deformable registration framework for contour propagation in MRgRT of prostate cancer. Methods: Three‐dimensional pelvic T2‐weighted MRIs of 143 prostate cancer patients undergoing radiotherapy were collected and divided into 110, 13, and 20 patients for training, validation, and testing. We designed a framework using convolutional neural networks (CNNs) for rigid and deformable registration. We selected the deformable registration network architecture among U‐Net, MS‐D Net, and LapIRN and optimized the training strategy (end‐to‐end vs. sequential). The framework was compared against an iterative baseline registration. We evaluated registration accuracy (the Dice and Hausdorff distance of the prostate and bladder contours), structural similarity index, and folding percentage to compare the methods. We also evaluated the framework's robustness to rigid and elastic deformations and bias field perturbations. Results: The end‐to‐end trained framework comprising LapIRN for the deformable component achieved the best median (interquartile range) prostate and bladder Dice of 0.89 (0.85–0.91) and 0.86 (0.80–0.91), respectively. This accuracy was comparable to the iterative baseline registration: prostate and bladder Dice of 0.91 (0.88–0.93) and 0.86 (0.80–0.92). The best models complete rigid and deformable registration in 0.002 (0.0005) and 0.74 (0.43) s (Nvidia Tesla V100‐PCIe 32 GB GPU), respectively. We found that the models are robust to translations up to 52 mm, rotations up to 15∘$^\circ$, elastic deformations up to 40 mm, and bias fields. Conclusions: Our proposed unsupervised, deep learning‐based registration framework can perform rigid and deformable registration in less than a second with contour propagation accuracy comparable with iterative registration. [ABSTRACT FROM AUTHOR]

Published
2024
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11. The Development and External Validation of Artificial Intelligence-Driven MRI-Based Models to Improve Prediction of Lesion-Specific Extraprostatic Extension in Patients with Prostate Cancer

Author

van den Berg, Ingeborg, primary, Soeterik, Timo F. W., additional, van der Hoeven, Erik J. R. J., additional, Claassen, Bart, additional, Brink, Wyger M., additional, Baas, Diederik J. H., additional, Sedelaar, J. P. Michiel, additional, Heine, Lizette, additional, Tol, Jim, additional, van der Voort van Zyp, Jochem R. N., additional, van den Berg, Cornelis A. T., additional, van den Bergh, Roderick C. N., additional, van Basten, Jean-Paul A., additional, and van Melick, Harm H. E., additional

Published
2023
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13. The Development and External Validation of Artificial Intelligence-Driven MRI-Based Models to Improve Prediction of Lesion-Specific Extraprostatic Extension in Patients with Prostate Cancer

Author

Computational Imaging, Arts-assistenten Radiotherapie, MS Radiotherapie, Cancer, van den Berg, Ingeborg, Soeterik, Timo F W, van der Hoeven, Erik J R J, Claassen, Bart, Brink, Wyger M, Baas, Diederik J H, Sedelaar, J P Michiel, Heine, Lizette, Tol, Jim, van der Voort van Zyp, Jochem R N, van den Berg, Cornelis A T, van den Bergh, Roderick C N, van Basten, Jean-Paul A, van Melick, Harm H E, Computational Imaging, Arts-assistenten Radiotherapie, MS Radiotherapie, Cancer, van den Berg, Ingeborg, Soeterik, Timo F W, van der Hoeven, Erik J R J, Claassen, Bart, Brink, Wyger M, Baas, Diederik J H, Sedelaar, J P Michiel, Heine, Lizette, Tol, Jim, van der Voort van Zyp, Jochem R N, van den Berg, Cornelis A T, van den Bergh, Roderick C N, van Basten, Jean-Paul A, and van Melick, Harm H E

Published
2023

14. Deep learning for automated contouring of neurovascular structures on magnetic resonance imaging for prostate cancer patients

Author

Computational Imaging, Cancer, Onderzoek Radiotherapie, MS Radiotherapie, Klinische Fysica RT, van den Berg, Ingeborg, Savenije, Mark H F, Teunissen, Frederik R, van de Pol, Sandrine M G, Rasing, Marnix J A, van Melick, Harm H E, Brink, Wyger M, de Boer, Johannes C J, van den Berg, Cornelis A T, van der Voort van Zyp, Jochem R N, Computational Imaging, Cancer, Onderzoek Radiotherapie, MS Radiotherapie, Klinische Fysica RT, van den Berg, Ingeborg, Savenije, Mark H F, Teunissen, Frederik R, van de Pol, Sandrine M G, Rasing, Marnix J A, van Melick, Harm H E, Brink, Wyger M, de Boer, Johannes C J, van den Berg, Cornelis A T, and van der Voort van Zyp, Jochem R N

Published
2023

15. Tolerability of concurrent external beam radiotherapy and [ 177Lu]Lu-PSMA-617 for node-positive prostate cancer in treatment naïve patients, phase I study (PROQURE-I trial).

Author

Cancer, Researchgr. Nucleaire Geneeskunde, MS Radiologie, MS Radiotherapie, van der Sar, Esmée C A, Braat, Arthur J A T, van der Voort-van Zyp, Jochem R N, van der Veen, Betty S, van Leeuwen, Pim J, de Vries-Huizing, Daphne M V, Hendrikx, Jeroen M A, Lam, Marnix G E H, Vogel, Wouter V, Cancer, Researchgr. Nucleaire Geneeskunde, MS Radiologie, MS Radiotherapie, van der Sar, Esmée C A, Braat, Arthur J A T, van der Voort-van Zyp, Jochem R N, van der Veen, Betty S, van Leeuwen, Pim J, de Vries-Huizing, Daphne M V, Hendrikx, Jeroen M A, Lam, Marnix G E H, and Vogel, Wouter V

Published
2023

16. Patient preferences for treatment modalities for localised prostate cancer

Author

Cancer, Onderzoek Radiotherapie, Trialbureau Beeld, MS Urologische Oncologie, MS Radiotherapie, Teunissen, Frederik R, Hehakaya, Charisma, Meijer, Richard P, van Melick, Harm H E, Verkooijen, Helena M, van der Voort van Zyp, Jochem R N, Cancer, Onderzoek Radiotherapie, Trialbureau Beeld, MS Urologische Oncologie, MS Radiotherapie, Teunissen, Frederik R, Hehakaya, Charisma, Meijer, Richard P, van Melick, Harm H E, Verkooijen, Helena M, and van der Voort van Zyp, Jochem R N

Published
2023

18. Additional file 1 of Tolerability of concurrent external beam radiotherapy and [177Lu]Lu-PSMA-617 for node-positive prostate cancer in treatment naïve patients, phase I study (PROQURE-I trial)

Author

van der Sar, Esmée C. A., Braat, Arthur J. A. T., van der Voort- van Zyp, Jochem R. N., van der Veen, Betty S., van Leeuwen, Pim J., de Vries-Huizing, Daphne M. V., Hendrikx, Jeroen M. A., Lam, Marnix G. E. H., and Vogel, Wouter V.

Abstract

Additional file 1: Table S1. Overview of study logistics.

Published
2023
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22. Development and internal validation of prediction models for biochemical failure and composite failure after focal salvage high intensity focused ultrasound for local radiorecurrent prostate cancer: Presentation of risk scores for individual patient prognoses

Author

Peters, Max, Kanthabalan, Abi, Shah, Taimur T., McCartan, Neil, Moore, Caroline M., Arya, Manit, van der Voort van Zyp, Jochem R., Moerland, Marinus A., Hindley, Richard G., Emberton, Mark, and Ahmed, Hashim U.

Published
2018
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23. ESTRO Breur lecture 2022: Real-time MRI-guided radiotherapy: The next generation standard?

Author

Cancer, Fysica Radiotherapie Research, Experimentele klinische fysica, MS Radiotherapie, Lagendijk, Jan J W, Raaymakers, Bas W, Intven, Martijn P W, van der Voort van Zyp, Jochem R N, Cancer, Fysica Radiotherapie Research, Experimentele klinische fysica, MS Radiotherapie, Lagendijk, Jan J W, Raaymakers, Bas W, Intven, Martijn P W, and van der Voort van Zyp, Jochem R N

Published
2022

24. Neurovascular-Sparing MR-Guided Adaptive Radiotherapy in Prostate Cancer; Defining the Potential Population for Erectile Function-Sparing Treatment

Author

Cancer, Onderzoek Radiotherapie, MS Radiotherapie, Trialbureau Beeld, Urologie Opleiding, Teunissen, Frederik R, van der Voort van Zyp, Jochem R N, Verkooijen, Helena M, Wortel, Ruud C, Cancer, Onderzoek Radiotherapie, MS Radiotherapie, Trialbureau Beeld, Urologie Opleiding, Teunissen, Frederik R, van der Voort van Zyp, Jochem R N, Verkooijen, Helena M, and Wortel, Ruud C

Published
2022

25. Daily online contouring and re-planning versus translation-only correction in neurovascular-sparing magnetic resonance-guided radiotherapy for localized prostate cancer

Author

Cancer, Onderzoek Radiotherapie, MS Radiotherapie, Trialbureau Beeld, Urologie Medisch Kinderen, Klinische Fysica RT, Teunissen, Frederik R, van der Voort van Zyp, Jochem R N, de Groot-van Breugel, Eline N, Verkooijen, Helena M, Wortel, Ruud C, de Boer, Johannes C J, Cancer, Onderzoek Radiotherapie, MS Radiotherapie, Trialbureau Beeld, Urologie Medisch Kinderen, Klinische Fysica RT, Teunissen, Frederik R, van der Voort van Zyp, Jochem R N, de Groot-van Breugel, Eline N, Verkooijen, Helena M, Wortel, Ruud C, and de Boer, Johannes C J

Published
2022

26. Clinical application of a sub-fractionation workflow for intrafraction re-planning during prostate radiotherapy treatment on a 1.5 Tesla MR-Linac: A practical method to mitigate intrafraction motion

Author

Arts-assistenten Radiotherapie, Cancer, Klinische Fysica RT, Fysica Radiotherapie Research, MS Radiotherapie, Experimentele klinische fysica, Willigenburg, Thomas, Zachiu, Cornel, Bol, Gijsbert H, de Groot-van Beugel, Eline N, Lagendijk, Jan J W, van der Voort van Zyp, Jochem R N, Raaymakers, Bas W, de Boer, Johannes C J, Arts-assistenten Radiotherapie, Cancer, Klinische Fysica RT, Fysica Radiotherapie Research, MS Radiotherapie, Experimentele klinische fysica, Willigenburg, Thomas, Zachiu, Cornel, Bol, Gijsbert H, de Groot-van Beugel, Eline N, Lagendijk, Jan J W, van der Voort van Zyp, Jochem R N, Raaymakers, Bas W, and de Boer, Johannes C J

Published
2022

27. Online adaptive MR-guided radiotherapy: Conformity of contour adaptation for prostate cancer, rectal cancer and lymph node oligometastases among radiation therapists and radiation oncologists

Author

Onderzoek Radiotherapie, Cancer, Klinische Fysica RT, MS Radiotherapie, Arts-assistenten Radiotherapie, Rasing, Marnix J A, Sikkes, Gonda G, Vissers, Nicole G P M, Kotte, Alexis N T J, Boudewijn, Joske H, Doornaert, Patricia A H, Eppinga, Wietse S C, Intven, Martijn, Rutgers, Reijer H A, Scheeren, Annick, Snoeren, Louk M W, Vlig, Tiny B, van der Voort van Zyp, Jochem R N, Wijkhuizen, Lisa M, van Rossum, Peter S N, Peters, Max, Jürgenliemk-Schulz, Ina M, Onderzoek Radiotherapie, Cancer, Klinische Fysica RT, MS Radiotherapie, Arts-assistenten Radiotherapie, Rasing, Marnix J A, Sikkes, Gonda G, Vissers, Nicole G P M, Kotte, Alexis N T J, Boudewijn, Joske H, Doornaert, Patricia A H, Eppinga, Wietse S C, Intven, Martijn, Rutgers, Reijer H A, Scheeren, Annick, Snoeren, Louk M W, Vlig, Tiny B, van der Voort van Zyp, Jochem R N, Wijkhuizen, Lisa M, van Rossum, Peter S N, Peters, Max, and Jürgenliemk-Schulz, Ina M

Published
2022

28. The first patient-reported outcomes from the Utrecht Prostate Cohort (UPC): the first platform facilitating 'trials within cohorts' (TwiCs) for the evaluation of interventions for prostate cancer

Author

Cancer, Onderzoek Radiotherapie, MS Urologische Oncologie, Trialbureau Beeld, MS Radiotherapie, Teunissen, Frederik R, Willigenburg, Thomas, Meijer, Richard P, van Melick, Harm H E, Verkooijen, Helena M, van der Voort van Zyp, Jochem R N, Cancer, Onderzoek Radiotherapie, MS Urologische Oncologie, Trialbureau Beeld, MS Radiotherapie, Teunissen, Frederik R, Willigenburg, Thomas, Meijer, Richard P, van Melick, Harm H E, Verkooijen, Helena M, and van der Voort van Zyp, Jochem R N

Published
2022

29. Fast and accurate deformable contour propagation for intra-fraction adaptive magnetic resonance-guided prostate radiotherapy

Author

Onderzoek Radiotherapie, Cancer, Klinische Fysica RT, Fysica Radiotherapie Research, MS Radiotherapie, Experimentele klinische fysica, Willigenburg, Thomas, Zachiu, Cornel, Lagendijk, Jan J W, van der Voort van Zyp, Jochem R N, de Boer, Hans C J, Raaymakers, Bas W, Onderzoek Radiotherapie, Cancer, Klinische Fysica RT, Fysica Radiotherapie Research, MS Radiotherapie, Experimentele klinische fysica, Willigenburg, Thomas, Zachiu, Cornel, Lagendijk, Jan J W, van der Voort van Zyp, Jochem R N, de Boer, Hans C J, and Raaymakers, Bas W

Published
2022

31. Tolerability of concurrent external beam radiotherapy and [177Lu]Lu-PSMA-617 for node-positive prostate cancer in treatment naïve patients, phase I study (PROQURE-I trial).

Author

van der Sar, Esmée C. A., Braat, Arthur J. A. T., van der Voort- van Zyp, Jochem R. N., van der Veen, Betty S., van Leeuwen, Pim J., de Vries-Huizing, Daphne M. V., Hendrikx, Jeroen M. A., Lam, Marnix G. E. H., and Vogel, Wouter V.

Subjects
PROSTATE cancer, CASTRATION-resistant prostate cancer, EXTERNAL beam radiotherapy, CANCER treatment, PROSTATE cancer patients, ANDROGEN deprivation therapy
Abstract

Background: Prostate cancer patients with locoregional lymph node disease at diagnosis (N1M0) still have a limited prognosis despite the improvements provided by aggressive curative intent multimodal locoregional external beam radiation therapy (EBRT) with systemic androgen deprivation therapy (ADT). Although some patients can be cured and the majority of patients have a long survival, the 5-year biochemical failure rate is currently 29–47%. [177Lu]Lu-PSMA-617 has shown impressive clinical and biochemical responses with low toxicity in salvage setting in metastatic castration-resistant prostate cancer. This study aims to explore the combination of standard EBRT and ADT complemented with a single administration of [177Lu]Lu-PSMA-617 in curative intent treatment for N1M0 prostate cancer. Hypothetically, this combined approach will enhance EBRT to better control macroscopic tumour localizations, and treat undetected microscopic disease locations inside and outside EBRT fields. Methods: The PROQURE-I study is a multicenter prospective phase I study investigating standard of care treatment (7 weeks EBRT and 3 years ADT) complemented with one concurrent cycle (three, six, or nine GBq) of systemic [177Lu]Lu-PSMA-617 administered in week two of EBRT. A maximum of 18 patients with PSMA-positive N1M0 prostate cancer will be included. The tolerability of adding [177Lu]Lu-PSMA-617 will be evaluated using a Bayesian Optimal Interval (BOIN) dose-escalation design. The primary objective is to determine the maximum tolerated dose (MTD) of a single cycle [177Lu]Lu-PSMA-617 when given concurrent with EBRT + ADT, defined as the occurrence of Common Terminology Criteria for Adverse Events (CTCAE) v 5.0 grade three or higher acute toxicity. Secondary objectives include: late toxicity at 6 months, dosimetric assessment, preliminary biochemical efficacy at 6 months, quality of life questionnaires, and pharmacokinetic modelling of [177Lu]Lu-PSMA-617. Discussion: This is the first prospective study to combine EBRT and ADT with [177Lu]Lu-PSMA-617 in treatment naïve men with N1M0 prostate cancer, and thereby explores the novel application of [177Lu]Lu-PSMA-617 in curative intent treatment. It is considered likely that this study will confirm tolerability as the combined toxicity of these treatments is expected to be limited. Increased efficacy is considered likely since both individual treatments have proven high anti-tumour effect as mono-treatments. Trial registration: ClinicalTrials, NCT05162573. Registered 7 October 2021. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Adaptive magnetic resonance-guided neurovascular-sparing radiotherapy for preservation of erectile function in prostate cancer patients

Author

Cancer, Onderzoek Radiotherapie, Urologie Onderzoek, Trialbureau Beeld, MS Radiotherapie, Teunissen, Frederik R, Wortel, Ruud C, Hes, Jochem, Willigenburg, Thomas, de Groot-van Breugel, Eline N, de Boer, Johannes C J, van Melick, Harm H E, Verkooijen, Helena M, van der Voort van Zyp, Jochem R N, Cancer, Onderzoek Radiotherapie, Urologie Onderzoek, Trialbureau Beeld, MS Radiotherapie, Teunissen, Frederik R, Wortel, Ruud C, Hes, Jochem, Willigenburg, Thomas, de Groot-van Breugel, Eline N, de Boer, Johannes C J, van Melick, Harm H E, Verkooijen, Helena M, and van der Voort van Zyp, Jochem R N

Published
2021

34. Development and internal validation of multivariable prediction models for biochemical failure after MRI-guided focal salvage high-dose-rate brachytherapy for radiorecurrent prostate cancer

Author

Onderzoek Radiotherapie, Cancer, MS Radiotherapie, Klinische Fysica RT, Fysica Radiotherapie Research, Arts-assistenten Radiotherapie, Willigenburg, Thomas, van Son, Marieke J, van de Pol, Sandrine M G, Eppinga, Wietse S C, Lagendijk, Jan J W, de Boer, Hans C J, Moerland, Marinus A, van der Voort van Zyp, Jochem R N, Peters, Max, Onderzoek Radiotherapie, Cancer, MS Radiotherapie, Klinische Fysica RT, Fysica Radiotherapie Research, Arts-assistenten Radiotherapie, Willigenburg, Thomas, van Son, Marieke J, van de Pol, Sandrine M G, Eppinga, Wietse S C, Lagendijk, Jan J W, de Boer, Hans C J, Moerland, Marinus A, van der Voort van Zyp, Jochem R N, and Peters, Max

Published
2021

35. Geometrical imaging accuracy, image quality and plan quality for prostate cancer treatments on a 1.5 T MRLinac in patients with a unilateral hip implant

Author

Klinische Fysica RT, Cancer, Experimentele klinische fysica, MS Radiotherapie, van Lier, Astrid L H M W, Meijers, Lieke T C, Philippens, Marielle E P, Hes, Jochem, Raaymakers, Bas W, van der Voort van Zyp, Jochem R N, de Boer, J C J, Klinische Fysica RT, Cancer, Experimentele klinische fysica, MS Radiotherapie, van Lier, Astrid L H M W, Meijers, Lieke T C, Philippens, Marielle E P, Hes, Jochem, Raaymakers, Bas W, van der Voort van Zyp, Jochem R N, and de Boer, J C J

Published
2021

36. Evaluation of daily online contour adaptation by radiation therapists for prostate cancer treatment on an MRI-guided linear accelerator

Author

Onderzoek Radiotherapie, Cancer, Fysica Radiotherapie Research, Arts-assistenten Radiotherapie, MS Radiotherapie, Klinische Fysica RT, Willigenburg, Thomas, de Muinck Keizer, Daan M, Peters, Max, Claes, An, Lagendijk, Jan J W, de Boer, Hans C J, van der Voort van Zyp, Jochem R N, Onderzoek Radiotherapie, Cancer, Fysica Radiotherapie Research, Arts-assistenten Radiotherapie, MS Radiotherapie, Klinische Fysica RT, Willigenburg, Thomas, de Muinck Keizer, Daan M, Peters, Max, Claes, An, Lagendijk, Jan J W, de Boer, Hans C J, and van der Voort van Zyp, Jochem R N

Published
2021

37. Long-term outcomes of two ablation techniques for treatment of radio-recurrent prostate cancer

Author

Arts-assistenten Radiotherapie, MS Radiotherapie, Cancer, Onderzoek Radiotherapie, Nair, Shiva M, Peters, Max, Kurver, Piet, Lavi, Arnon, Verhoeff, Joost J C, van der Voort van Zyp, Jochem R N, van Son, Marieke J, Chin, Joseph L, Arts-assistenten Radiotherapie, MS Radiotherapie, Cancer, Onderzoek Radiotherapie, Nair, Shiva M, Peters, Max, Kurver, Piet, Lavi, Arnon, Verhoeff, Joost J C, van der Voort van Zyp, Jochem R N, van Son, Marieke J, and Chin, Joseph L

Published
2021

38. Problems and Promises of Introducing the Magnetic Resonance Imaging Linear Accelerator Into Routine Care: The Case of Prostate Cancer

Author

Hehakaya, Charisma, Van der Voort van Zyp, Jochem R., Lagendijk, Jan J. W., Grobbee, Diederick E., Verkooijen, Helena M., Moors, Ellen H. M., Innovation and Sustainability, Innovation Studies, Innovation and Sustainability, and Innovation Studies

Subjects
0301 basic medicine, Cancer Research, medicine.medical_specialty, Staffing, lcsh:RC254-282, cancer care, Health administration, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, medicine, Medical physics, implementation, Empirical evidence, Routine care, Original Research, MR-Linac, Abandonment (legal), Professional development, image-guided radiotherapy, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, prostate cancer, medicine.disease, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, MRI-guided radiotherapy, healthcare management, Business, qualitative research, Qualitative research
Abstract

The new radiotherapy high field, 1.5 Tesla MRI-guided linear accelerator (MR-Linac) is being clinically introduced. Sensing and evaluating opportunities and barriers at an early stage will facilitate its eventual scale-up. This study investigates the opportunities and barriers to the implementation of MR-Linac into prostate cancer care based on 43 semi-structured interviews with Dutch oncology care professionals, hospital and division directors, patients, payers and industry. The analysis was guided by the Non-adoption, Abandonment, Scale-up, Spread, and Sustainability framework of new medical technologies and services. Opportunities included: the acquirement of (1) advanced MRI-guided radiotherapy technology with (2) the potential for improved patient outcomes and (3) economic benefits, as well as (4) professional development and (5) a higher hospital quality profile. Barriers included: (1) technical complexities, (2) substantial staffing and structural investments, (3) the current lack of empirical evidence of clinical benefits, (4) professional silos, and (5) the presence of patient referral patterns. While our study confirms the expected technical and clinical prospects from the literature, it also reveals economic, organizational, and socio-political challenges.

Published
2020
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39. Problems and Promises of Introducing the Magnetic Resonance Imaging Linear Accelerator Into Routine Care: The Case of Prostate Cancer

Author

Innovation and Sustainability, Innovation Studies, Hehakaya, Charisma, Van der Voort van Zyp, Jochem R., Lagendijk, Jan J. W., Grobbee, Diederick E., Verkooijen, Helena M., Moors, Ellen H. M., Innovation and Sustainability, Innovation Studies, Hehakaya, Charisma, Van der Voort van Zyp, Jochem R., Lagendijk, Jan J. W., Grobbee, Diederick E., Verkooijen, Helena M., and Moors, Ellen H. M.

Published
2020

40. Anatomically-adaptive multi-modal image registration for image-guided external-beam radiotherapy

Author

Experimentele klinische fysica, Cancer, Researchgr. Beeldg. Moleculaire Interv., Onderzoek Radiotherapie, MS Radiotherapie, Klinische Fysica RT, Zachiu, Cornel, Denis de Senneville, Baudouin, Willigenburg, Thomas, van der Voort van Zyp, Jochem R N, de Boer, J C J, Raaymakers, Bas W, Ries, Mario G, Experimentele klinische fysica, Cancer, Researchgr. Beeldg. Moleculaire Interv., Onderzoek Radiotherapie, MS Radiotherapie, Klinische Fysica RT, Zachiu, Cornel, Denis de Senneville, Baudouin, Willigenburg, Thomas, van der Voort van Zyp, Jochem R N, de Boer, J C J, Raaymakers, Bas W, and Ries, Mario G

Published
2020

41. Problems and Promises of Introducing the Magnetic Resonance Imaging Linear Accelerator Into Routine Care: The Case of Prostate Cancer

Author

Cancer, Trialbureau Beeld, MS Radiotherapie, Fysica Radiotherapie Research, Klinische Fysica RT, Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 9, JC onderzoeksprogramma Kanker, Epi Kanker Team A, Hehakaya, Charisma, Van der Voort van Zyp, Jochem R, Lagendijk, Jan J W, Grobbee, Diederick E, Verkooijen, Helena M, Moors, Ellen H M, Cancer, Trialbureau Beeld, MS Radiotherapie, Fysica Radiotherapie Research, Klinische Fysica RT, Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 9, JC onderzoeksprogramma Kanker, Epi Kanker Team A, Hehakaya, Charisma, Van der Voort van Zyp, Jochem R, Lagendijk, Jan J W, Grobbee, Diederick E, Verkooijen, Helena M, and Moors, Ellen H M

Published
2020

43. MRI‐based synthetic CT shows equivalence to conventional CT for the morphological assessment of the hip joint.

Author

Florkow, Mateusz C., Willemsen, Koen, Zijlstra, Frank, Foppen, Wouter, van der Wal, Bart C. H., van der Voort van Zyp, Jochem R. N., Viergever, Max A., Castelein, René M., Weinans, Harrie, van Stralen, Marijn, Sakkers, Ralph J. B., and Seevinck, Peter R.

Subjects
HIP joint, FEMUR head, COMPUTED tomography, MAGNETIC resonance imaging, INTRACLASS correlation, ORTHOPEDISTS
Abstract

This study evaluated the accuracy of synthetic computed tomography (sCT), as compared to CT, for the 3D assessment of the hip morphology. Thirty male patients with asymptomatic hips, referred for magnetic resonance (MR) imaging and CT, were included in this retrospective study. sCT images were generated from three‐dimensional radiofrequency‐spoiled T1‐weighted multi‐echo gradient‐echo MR images using a commercially available deep learning‐enabled software and were compared with CT images through mean error and surface distance computation and by means of eight clinical morphometric parameters relevant for hip care. Parameters included center‐edge angle (CEA), sharp angle, acetabular index, extrusion index, femoral head center‐to‐midline distance, acetabular version (AV), and anterior and posterior acetabular sector angles. They were measured by two senior orthopedic surgeons and a radiologist in‐training on CT and sCT images. The reliability and agreement of CT‐ and sCT‐based measurements were assessed using intraclass correlation coefficients (ICCs) for absolute agreement, Bland–Altman plots, and two one‐sided tests for equivalence. The surface distance between CT‐ and sCT‐based bone models were on average submillimeter. CT‐ and sCT‐based measurements showed moderate to excellent interobserver and intraobserver correlation (0.56 < ICC < 0.99). In particular, the inter/intraobserver agreements were good for AV (ICC > 0.75). For CEA, the intraobserver agreement was good (ICC > 0.75) and the interobserver agreement was moderate (ICC > 0.69). Limits of agreements were similar between intraobserver CT and intermodal measurements. All measurements were found statistically equivalent, with average intermodal differences within the intraobserver limits of agreement. In conclusion, sCT and CT were equivalent for the assessment of the hip joint bone morphology. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Soft-tissue prostate intrafraction motion tracking in 3D cine-MR for MR-guided radiotherapy

Author

de Muinck Keizer, Daan M, Kerkmeijer, Linda G W, Maspero, Matteo, Andreychenko, Anna, van der Voort van Zyp, Jochem R N, Van den Berg, Cornelis A T, Raaymakers, Bas W, Lagendijk, Jan J W, de Boer, J C J, de Muinck Keizer, Daan M, Kerkmeijer, Linda G W, Maspero, Matteo, Andreychenko, Anna, van der Voort van Zyp, Jochem R N, Van den Berg, Cornelis A T, Raaymakers, Bas W, Lagendijk, Jan J W, and de Boer, J C J

Published
2019

46. Visualization of gold fiducial markers in the prostate using phase-cycled bSSFP imaging for MRI-only radiotherapy

Author

Shcherbakova, Yulia, Bartels, Lambertus Wilbert, Mandija, Stefano, Beld, Ellis, Seevinck, Peter R, van der Voort van Zyp, Jochem R N, Kerkmeijer, Linda G W, Moonen, Chrit T W, Lagendijk, Jan J W, Van den Berg, Cornelis A T, Shcherbakova, Yulia, Bartels, Lambertus Wilbert, Mandija, Stefano, Beld, Ellis, Seevinck, Peter R, van der Voort van Zyp, Jochem R N, Kerkmeijer, Linda G W, Moonen, Chrit T W, Lagendijk, Jan J W, and Van den Berg, Cornelis A T

Published
2019

47. Visualization of gold fiducial markers in the prostate using phase-cycled bSSFP imaging for MRI-only radiotherapy

Author

Beeldverwerking ISI, Cancer, Researchgr. Beeldg. Moleculaire Interv., Computational Imaging, Circulatory Health, Experimentele klinische fysica, Regenerative Medicine and Stem Cells, MS Radiotherapie, Fysica Radiotherapie Research, Klinische Fysica RT, Shcherbakova, Yulia, Bartels, Lambertus Wilbert, Mandija, Stefano, Beld, Ellis, Seevinck, Peter R, van der Voort van Zyp, Jochem R N, Kerkmeijer, Linda G W, Moonen, Chrit T W, Lagendijk, Jan J W, Van den Berg, Cornelis A T, Beeldverwerking ISI, Cancer, Researchgr. Beeldg. Moleculaire Interv., Computational Imaging, Circulatory Health, Experimentele klinische fysica, Regenerative Medicine and Stem Cells, MS Radiotherapie, Fysica Radiotherapie Research, Klinische Fysica RT, Shcherbakova, Yulia, Bartels, Lambertus Wilbert, Mandija, Stefano, Beld, Ellis, Seevinck, Peter R, van der Voort van Zyp, Jochem R N, Kerkmeijer, Linda G W, Moonen, Chrit T W, Lagendijk, Jan J W, and Van den Berg, Cornelis A T

Published
2019

48. Soft-tissue prostate intrafraction motion tracking in 3D cine-MR for MR-guided radiotherapy

Author

Radiotherapie, Fysica Radiotherapie Research, MS Radiotherapie, Cancer, Computational Imaging, Experimentele klinische fysica, Klinische Fysica RT, de Muinck Keizer, Daan M, Kerkmeijer, Linda G W, Maspero, Matteo, Andreychenko, Anna, van der Voort van Zyp, Jochem R N, Van den Berg, Cornelis A T, Raaymakers, Bas W, Lagendijk, Jan J W, de Boer, J C J, Radiotherapie, Fysica Radiotherapie Research, MS Radiotherapie, Cancer, Computational Imaging, Experimentele klinische fysica, Klinische Fysica RT, de Muinck Keizer, Daan M, Kerkmeijer, Linda G W, Maspero, Matteo, Andreychenko, Anna, van der Voort van Zyp, Jochem R N, Van den Berg, Cornelis A T, Raaymakers, Bas W, Lagendijk, Jan J W, and de Boer, J C J

Published
2019

49. Risicopercepties van mannen met gelokaliseerde prostaatkanker

Author

van Stam, M A, Aaronson, Neil K, van der Poel, Henk G, van der Voort van Zyp, Jochem R N, Tillier, Corinne N, Horenblas, Simon, and Bosch, J L H R

Subjects
Male, Prostatic Neoplasms/psychology, Neoplasm Recurrence, Local/psychology, Prostatectomy/adverse effects, Middle Aged, Prostate-Specific Antigen, Radiotherapy/adverse effects, Multicenter Study, Urinary Incontinence/etiology, Surveys and Questionnaires, Watchful Waiting/methods, Journal Article, Health Status Indicators, Humans, Comparative Study, Longitudinal Studies, Prospective Studies, Erectile Dysfunction/etiology, Correlation of Data, Attitude to Health, Aged
Abstract

OBJECTIVE: To assess the accuracy of patients' perceptions of the risks associated with localised prostate cancer treatments (radical prostatectomy [RP], radiotherapy [RT], and active surveillance [AS]), and to identify correlates of misperceptions. PATIENTS AND METHODS: We used baseline data (questionnaires completed after treatment information was provided but before treatment) of 426 patients with newly diagnosed localised prostate cancer who participated (87% response rate) in a prospective, longitudinal, multicentre study. Patients' pretreatment perceptions of differences in adverse outcomes of treatments were compared to those based on the literature. We used univariate and multivariate linear regression to identify correlates of misperceptions. RESULTS: About two-thirds (68%, n = 211) of the patients did not understand that the risk of disease recurrence is comparable between RP and RT. More than half of the patients did not comprehend that RP patients are at greater risk of urinary incontinence (65%, n = 202) and erectile dysfunction (61%, n = 190), and less at risk of bowel problems (53%, n = 211) compared to RT patients. Many patients overestimated the risk of requiring definitive treatment following AS (45%, n = 157) and did not understand that mortality rates following AS, RP, and RT are comparable (80%, n = 333). Consulting a radiotherapist or a clinical nurse specialist was positively associated with, and emotional distress was negatively associated with, better understanding of the risks (P < 0.05), although effect sizes were small. CONCLUSION: Prior to choosing treatment, most patients with prostate cancer poorly understood the differences in treatment risks. Greater efforts should be made to better understand why these misperceptions occur and, most importantly, how they can be corrected.

Published
2018

50. Visualization of gold fiducial markers in the prostate using phase-cycled bSSFP imaging for MRI-only radiotherapy

Author

Shcherbakova, Yulia, primary, Bartels, Lambertus W, additional, Mandija, Stefano, additional, Beld, Ellis, additional, Seevinck, Peter R, additional, van der Voort van Zyp, Jochem R N, additional, Kerkmeijer, Linda G W, additional, Moonen, Chrit T W, additional, Lagendijk, Jan J W, additional, and van den Berg, Cornelis A T, additional

Published
2019
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