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213 results on '"Van der Vlies, Pieter"'

2. Shared DNA methylation signatures in childhood allergy: The MeDALL study

Author

Xu, Cheng-Jian, Gruzieva, Olena, Qi, Cancan, Esplugues, Ana, Gehring, Ulrike, Bergström, Anna, Mason, Dan, Chatzi, Leda, Porta, Daniela, Lodrup Carlsen, Karin C., Baïz, Nour, Madore, Anne-Marie, Alenius, Harri, van Rijkom, Bianca, Jankipersadsing, Soesma A., van der Vlies, Pieter, Kull, Inger, van Hage, Marianne, Bustamante, Mariona, Lertxundi, Aitana, Torrent, Matias, Santorelli, Gillian, Fantini, Maria Pia, Hovland, Vegard, Pesce, Giancarlo, Fyhrquist, Nanna, Laatikainen, Tiina, Nawijn, Martijn C., Li, Yang, Wijmenga, Cisca, Netea, Mihai G., Bousquet, Jean, Anto, Josep M., Laprise, Catherine, Haahtela, Tari, Annesi-Maesano, Isabella, Carlsen, Kai-Håkon, Gori, Davide, Kogevinas, Manolis, Wright, John, Söderhäll, Cilla, Vonk, Judith M., Sunyer, Jordi, Melén, Erik, and Koppelman, Gerard H.

Published
2021
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3. DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis

Author

Joubert, Bonnie R, Felix, Janine F, Yousefi, Paul, Bakulski, Kelly M, Just, Allan C, Breton, Carrie, Reese, Sarah E, Markunas, Christina A, Richmond, Rebecca C, Xu, Cheng-Jian, Küpers, Leanne K, Oh, Sam S, Hoyo, Cathrine, Gruzieva, Olena, Söderhäll, Cilla, Salas, Lucas A, Baïz, Nour, Zhang, Hongmei, Lepeule, Johanna, Ruiz, Carlos, Ligthart, Symen, Wang, Tianyuan, Taylor, Jack A, Duijts, Liesbeth, Sharp, Gemma C, Jankipersadsing, Soesma A, Nilsen, Roy M, Vaez, Ahmad, Fallin, M Daniele, Hu, Donglei, Litonjua, Augusto A, Fuemmeler, Bernard F, Huen, Karen, Kere, Juha, Kull, Inger, Munthe-Kaas, Monica Cheng, Gehring, Ulrike, Bustamante, Mariona, Saurel-Coubizolles, Marie José, Quraishi, Bilal M, Ren, Jie, Tost, Jörg, Gonzalez, Juan R, Peters, Marjolein J, Håberg, Siri E, Xu, Zongli, van Meurs, Joyce B, Gaunt, Tom R, Kerkhof, Marjan, Corpeleijn, Eva, Feinberg, Andrew P, Eng, Celeste, Baccarelli, Andrea A, Neelon, Sara E Benjamin, Bradman, Asa, Merid, Simon Kebede, Bergström, Anna, Herceg, Zdenko, Hernandez-Vargas, Hector, Brunekreef, Bert, Pinart, Mariona, Heude, Barbara, Ewart, Susan, Yao, Jin, Lemonnier, Nathanaël, Franco, Oscar H, Wu, Michael C, Hofman, Albert, McArdle, Wendy, Van der Vlies, Pieter, Falahi, Fahimeh, Gillman, Matthew W, Barcellos, Lisa F, Kumar, Ashish, Wickman, Magnus, Guerra, Stefano, Charles, Marie-Aline, Holloway, John, Auffray, Charles, Tiemeier, Henning W, Smith, George Davey, Postma, Dirkje, Hivert, Marie-France, Eskenazi, Brenda, Vrijheid, Martine, Arshad, Hasan, Antó, Josep M, Dehghan, Abbas, Karmaus, Wilfried, Annesi-Maesano, Isabella, Sunyer, Jordi, Ghantous, Akram, Pershagen, Göran, Holland, Nina, Murphy, Susan K, DeMeo, Dawn L, Burchard, Esteban G, Ladd-Acosta, Christine, Snieder, Harold, and Nystad, Wenche

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Health Sciences, Genetics, Human Genome, Prevention, Tobacco Smoke and Health, Tobacco, Perinatal Period - Conditions Originating in Perinatal Period, Pediatric, Clinical Research, 2.1 Biological and endogenous factors, Reproductive health and childbirth, Respiratory, Good Health and Well Being, Asthma, Child, Child, Preschool, Chromosome Mapping, Cleft Lip, Cleft Palate, DNA Methylation, Epigenesis, Genetic, Female, Genetic Association Studies, Humans, Infant, Infant, Newborn, Pregnancy, Smoking, White People, Medical and Health Sciences, Genetics & Heredity, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Epigenetic modifications, including DNA methylation, represent a potential mechanism for environmental impacts on human disease. Maternal smoking in pregnancy remains an important public health problem that impacts child health in a myriad of ways and has potential lifelong consequences. The mechanisms are largely unknown, but epigenetics most likely plays a role. We formed the Pregnancy And Childhood Epigenetics (PACE) consortium and meta-analyzed, across 13 cohorts (n = 6,685), the association between maternal smoking in pregnancy and newborn blood DNA methylation at over 450,000 CpG sites (CpGs) by using the Illumina 450K BeadChip. Over 6,000 CpGs were differentially methylated in relation to maternal smoking at genome-wide statistical significance (false discovery rate, 5%), including 2,965 CpGs corresponding to 2,017 genes not previously related to smoking and methylation in either newborns or adults. Several genes are relevant to diseases that can be caused by maternal smoking (e.g., orofacial clefts and asthma) or adult smoking (e.g., certain cancers). A number of differentially methylated CpGs were associated with gene expression. We observed enrichment in pathways and processes critical to development. In older children (5 cohorts, n = 3,187), 100% of CpGs gave at least nominal levels of significance, far more than expected by chance (p value < 2.2 × 10(-16)). Results were robust to different normalization methods used across studies and cell type adjustment. In this large scale meta-analysis of methylation data, we identified numerous loci involved in response to maternal smoking in pregnancy with persistence into later childhood and provide insights into mechanisms underlying effects of this important exposure.

Published
2016

4. Lessons learned from whole exome sequencing in multiplex families affected by a complex genetic disorder, intracranial aneurysm.

Author

Farlow, Janice L, Lin, Hai, Sauerbeck, Laura, Lai, Dongbing, Koller, Daniel L, Pugh, Elizabeth, Hetrick, Kurt, Ling, Hua, Kleinloog, Rachel, van der Vlies, Pieter, Deelen, Patrick, Swertz, Morris A, Verweij, Bon H, Regli, Luca, Rinkel, Gabriel JE, Ruigrok, Ynte M, Doheny, Kimberly, Liu, Yunlong, Broderick, Joseph, Foroud, Tatiana, and FIA Study Investigators

Subjects
FIA Study Investigators, Humans, Intracranial Aneurysm, Genetic Predisposition to Disease, Membrane Proteins, Cohort Studies, Chromosome Mapping, Pedigree, Sequence Analysis, DNA, Computational Biology, Base Sequence, Phenotype, Molecular Sequence Data, Genetic Variation, Exome, Sequence Analysis, DNA, General Science & Technology
Abstract

Genetic risk factors for intracranial aneurysm (IA) are not yet fully understood. Genomewide association studies have been successful at identifying common variants; however, the role of rare variation in IA susceptibility has not been fully explored. In this study, we report the use of whole exome sequencing (WES) in seven densely-affected families (45 individuals) recruited as part of the Familial Intracranial Aneurysm study. WES variants were prioritized by functional prediction, frequency, predicted pathogenicity, and segregation within families. Using these criteria, 68 variants in 68 genes were prioritized across the seven families. Of the genes that were expressed in IA tissue, one gene (TMEM132B) was differentially expressed in aneurysmal samples (n=44) as compared to control samples (n=16) (false discovery rate adjusted p-value=0.023). We demonstrate that sequencing of densely affected families permits exploration of the role of rare variants in a relatively common disease such as IA, although there are important study design considerations for applying sequencing to complex disorders. In this study, we explore methods of WES variant prioritization, including the incorporation of unaffected individuals, multipoint linkage analysis, biological pathway information, and transcriptome profiling. Further studies are needed to validate and characterize the set of variants and genes identified in this study.

Published
2015

5. DNA methylation in childhood asthma: an epigenome-wide meta-analysis

Author

Xu, Cheng-Jian, Söderhäll, Cilla, Bustamante, Mariona, Baïz, Nour, Gruzieva, Olena, Gehring, Ulrike, Mason, Dan, Chatzi, Leda, Basterrechea, Mikel, Llop, Sabrina, Torrent, Maties, Forastiere, Francesco, Fantini, Maria Pia, Carlsen, Karin C Lødrup, Haahtela, Tari, Morin, Andréanne, Kerkhof, Marjan, Merid, Simon Kebede, van Rijkom, Bianca, Jankipersadsing, Soesma A, Bonder, Marc Jan, Ballereau, Stephane, Vermeulen, Cornelis J, Aguirre-Gamboa, Raul, de Jongste, Johan C, Smit, Henriette A, Kumar, Ashish, Pershagen, Göran, Guerra, Stefano, Garcia-Aymerich, Judith, Greco, Dario, Reinius, Lovisa, McEachan, Rosemary R C, Azad, Raf, Hovland, Vegard, Mowinckel, Petter, Alenius, Harri, Fyhrquist, Nanna, Lemonnier, Nathanaël, Pellet, Johann, Auffray, Charles, van der Vlies, Pieter, van Diemen, Cleo C, Li, Yang, Wijmenga, Cisca, Netea, Mihai G, Moffatt, Miriam F, Cookson, William O C M, Anto, Josep M, Bousquet, Jean, Laatikainen, Tiina, Laprise, Catherine, Carlsen, Kai-Håkon, Gori, Davide, Porta, Daniela, Iñiguez, Carmen, Bilbao, Jose Ramon, Kogevinas, Manolis, Wright, John, Brunekreef, Bert, Kere, Juha, Nawijn, Martijn C, Annesi-Maesano, Isabella, Sunyer, Jordi, Melén, Erik, and Koppelman, Gerard H

Published
2018
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6. Genetic and epigenetic regulation of YKL-40 in childhood

Author

Guerra, Stefano, Melén, Erik, Sunyer, Jordi, Xu, Cheng-Jian, Lavi, Iris, Benet, Marta, Bustamante, Mariona, Carsin, Anne-Elie, Dobaño, Carlota, Guxens, Mònica, Tischer, Christina, Vrijheid, Martine, Kull, Inger, Bergström, Anna, Kumar, Ashish, Söderhäll, Cilla, Gehring, Ulrike, Dijkstra, Dorieke J., van der Vlies, Pieter, Wickman, Magnus, Bousquet, Jean, Postma, Dirkje S., Anto, Josep M., and Koppelman, Gerard H.

Published
2018
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9. Data from A Transcriptionally Distinct CXCL13+CD103+CD8+ T-cell Population Is Associated with B-cell Recruitment and Neoantigen Load in Human Cancer

Author

Workel, Hagma H., primary, Lubbers, Joyce M., primary, Arnold, Roland, primary, Prins, Thalina M., primary, van der Vlies, Pieter, primary, de Lange, Kim, primary, Bosse, Tjalling, primary, van Gool, Inge C., primary, Eggink, Florine A., primary, Wouters, Maartje C.A., primary, Komdeur, Fenne L., primary, van der Slikke, Elisabeth C., primary, Creutzberg, Carien L., primary, Kol, Arjan, primary, Plat, Annechien, primary, Glaire, Mark, primary, Church, David N., primary, Nijman, Hans W., primary, and de Bruyn, Marco, primary

Published
2023
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10. Supplementary Table 7 from A Transcriptionally Distinct CXCL13+CD103+CD8+ T-cell Population Is Associated with B-cell Recruitment and Neoantigen Load in Human Cancer

Author

Workel, Hagma H., primary, Lubbers, Joyce M., primary, Arnold, Roland, primary, Prins, Thalina M., primary, van der Vlies, Pieter, primary, de Lange, Kim, primary, Bosse, Tjalling, primary, van Gool, Inge C., primary, Eggink, Florine A., primary, Wouters, Maartje C.A., primary, Komdeur, Fenne L., primary, van der Slikke, Elisabeth C., primary, Creutzberg, Carien L., primary, Kol, Arjan, primary, Plat, Annechien, primary, Glaire, Mark, primary, Church, David N., primary, Nijman, Hans W., primary, and de Bruyn, Marco, primary

Published
2023
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11. Supplementary Tables 1-6, 8 from A Transcriptionally Distinct CXCL13+CD103+CD8+ T-cell Population Is Associated with B-cell Recruitment and Neoantigen Load in Human Cancer

Author

Workel, Hagma H., primary, Lubbers, Joyce M., primary, Arnold, Roland, primary, Prins, Thalina M., primary, van der Vlies, Pieter, primary, de Lange, Kim, primary, Bosse, Tjalling, primary, van Gool, Inge C., primary, Eggink, Florine A., primary, Wouters, Maartje C.A., primary, Komdeur, Fenne L., primary, van der Slikke, Elisabeth C., primary, Creutzberg, Carien L., primary, Kol, Arjan, primary, Plat, Annechien, primary, Glaire, Mark, primary, Church, David N., primary, Nijman, Hans W., primary, and de Bruyn, Marco, primary

Published
2023
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12. Supplementary Figures from A Transcriptionally Distinct CXCL13+CD103+CD8+ T-cell Population Is Associated with B-cell Recruitment and Neoantigen Load in Human Cancer

Author

Workel, Hagma H., primary, Lubbers, Joyce M., primary, Arnold, Roland, primary, Prins, Thalina M., primary, van der Vlies, Pieter, primary, de Lange, Kim, primary, Bosse, Tjalling, primary, van Gool, Inge C., primary, Eggink, Florine A., primary, Wouters, Maartje C.A., primary, Komdeur, Fenne L., primary, van der Slikke, Elisabeth C., primary, Creutzberg, Carien L., primary, Kol, Arjan, primary, Plat, Annechien, primary, Glaire, Mark, primary, Church, David N., primary, Nijman, Hans W., primary, and de Bruyn, Marco, primary

Published
2023
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20. RNA Sequencing Analysis of Intracranial Aneurysm Walls Reveals Involvement of Lysosomes and Immunoglobulins in Rupture

Author

Kleinloog, Rachel, Verweij, Bon H., van der Vlies, Pieter, Deelen, Patrick, Swertz, Morris A., de Muynck, Louis, Van Damme, Philip, Giuliani, Fabrizio, Regli, Luca, van der Zwan, Albert, Berkelbach van der Sprenkel, Jan W., Han, K. Sen, Gosselaar, Peter, van Rijen, Peter C., Korkmaz, Emine, Post, Jan A., Rinkel, Gabriel J.E., Veldink, Jan H., and Ruigrok, Ynte M.

Published
2016
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23. Shared DNA methylation signatures in childhood allergy: The MeDALL study

Author

Medicina preventiva y salud pública, Prebentzio medikuntza eta osasun publikoa, Xu, Cheng-Jian, Gruzieva, Olena, Qi, Cancan, Esplugues, Ana, Gehring, Ulrike, Bergström, Anna, Mason, Dan, Chatzi, Leda, Porta, Daniela, Lodrup Carlsen, Karin C., Baïz, Nour, Madore, Anne-Marie, Alenius, Harri, Van Rijkom, Bianca, Jankipersadsing, Soesma A., Van der Vlies, Pieter, Kull, Inger, Van Hage, Marianne, Bustamante, Mariona, Lertxundi Manterola, Aitana, Torrent, Matias, Santore, Gillian, Fantini, Maria Pia, Hovland, Vegard, Pesce, Giancarlo, BIOS Consortium, Fyhrquist, Nanna, Laatikainen, Tiina, Nawijn, Martijn C., Li, Yang, Wijmenga, Cisca, Netea, Mihai G., Bousquet, Jean, Anto, Josep M., Laprise, Catherine, Haahtela, Tari, Annesi-Maesano, Isabella, Carlsen, Kai-Håkon, Gori, Davide, Kogevinas, Manolis, Wright, John, Söderhäll, Cilla, Vonk, Judith M., Sunyer, Jordi, Melén, Erik, Koppelman, Gerard H., Medicina preventiva y salud pública, Prebentzio medikuntza eta osasun publikoa, Xu, Cheng-Jian, Gruzieva, Olena, Qi, Cancan, Esplugues, Ana, Gehring, Ulrike, Bergström, Anna, Mason, Dan, Chatzi, Leda, Porta, Daniela, Lodrup Carlsen, Karin C., Baïz, Nour, Madore, Anne-Marie, Alenius, Harri, Van Rijkom, Bianca, Jankipersadsing, Soesma A., Van der Vlies, Pieter, Kull, Inger, Van Hage, Marianne, Bustamante, Mariona, Lertxundi Manterola, Aitana, Torrent, Matias, Santore, Gillian, Fantini, Maria Pia, Hovland, Vegard, Pesce, Giancarlo, BIOS Consortium, Fyhrquist, Nanna, Laatikainen, Tiina, Nawijn, Martijn C., Li, Yang, Wijmenga, Cisca, Netea, Mihai G., Bousquet, Jean, Anto, Josep M., Laprise, Catherine, Haahtela, Tari, Annesi-Maesano, Isabella, Carlsen, Kai-Håkon, Gori, Davide, Kogevinas, Manolis, Wright, John, Söderhäll, Cilla, Vonk, Judith M., Sunyer, Jordi, Melén, Erik, and Koppelman, Gerard H.

Abstract

BACKGROUND: Differential DNA methylation associated with allergy might provide novel insights into the shared or unique etiology of asthma, rhinitis, and eczema. OBJECTIVE: We sought to identify DNA methylationprofilesassociated with childhood allergy. METHODS: Within the European Mechanisms of the Development of Allergy (MeDALL) consortium, we performed an epigenome-wide association study of whole blood DNA methylation by using a cross-sectional design. Allergy was defined as having symptoms from at least 1 allergic disease (asthma, rhinitis, or eczema) and positive serum-specific IgE to common aeroallergens. The discovery study included 219 case patients and 417 controls at age 4 years and 228 case patients and 593 controls at age 8 years from 3 birth cohorts, with replication analyses in 325 case patients and 1111 controls. We performed additional analyses on 21 replicated sites in 785 case patients and 2124 controls by allergic symptoms only from 8 cohorts, 3 of which were not previously included in analyses. RESULTS: We identified 80 differentially methylated CpG sites that showed a 1% to 3% methylation difference in the discovery phase, of which 21 (including 5 novel CpG sites) passed genome-wide significance after meta-analysis. All 21 CpG sites were also significantly differentially methylated with allergic symptoms and shared between asthma, rhinitis, and eczema. The 21 CpG sites mapped to relevant genes, including ACOT7, LMAN3, and CLDN23. All 21 CpG sties were differently methylated in asthma in isolated eosinophils, and 10 were replicated in respiratory epithelium. CONCLUSION: Reduced whole blood DNA methylation at 21 CpG sites was significantly associated with childhood allergy. The findings provide novel insights into the shared molecular mechanisms underlying asthma, rhinitis, and eczema.

Published
2021

26. Wnt Signaling and Dupuytrenʼs Disease

Author

Dolmans, Guido H., Werker, Paul M., Hennies, Hans C., Furniss, Dominic, Festen, Eleonora A., Franke, Lude, Becker, Kerstin, van der Vlies, Pieter, Wolffenbuttel, Bruce H., Tinschert, Sigrid, Toliat, Mohammad R., Nothnagel, Michael, Franke, Andre, Klopp, Norman, Wichmann, H.-Erich, Nürnberg, Peter, Giele, Henk, Ophoff, Roel A., and Wijmenga, Cisca

Published
2011
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29. A DGGE System for Comprehensive Mutation Screening of BRCA1 and BRCA2:: Application in a Dutch Cancer Clinic Setting

Author

van der Hout, Annemarie H., van den Ouweland, Ans M.W., van der Luijt, Rob B., Gille, Hans J.P., Bodmer, Daniëlle, Brüggenwirth, Hennie, Mulder, Inge M., van der Vlies, Pieter, Elfferich, Peter, Huisman, Maarten T., ten Berge, Annelies M., Kromosoeto, Joan, Jansen, Rumo P.M., van Zon, Patrick H.A., Vriesman, Thyrsa, Arts, Neeltje, Boutmy-de Lange, Majella, Oosterwijk, Jan C., Meijers-Heijboer, Hanne, Ausems, Margreet G.E.M., Hoogerbrugge, Nicoline, Verhoef, Senno, Halley, Dicky J.J., Vos, Yvonne J., Hogervorst, Frans, Ligtenberg, Marjolijn, and Hofstra, Robert M.W.

Published
2006
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32. A Transcriptionally Distinct CXCL13+CD103+CD8+ T-cell Population Is Associated with B-cell Recruitment and Neoantigen Load in Human Cancer

Author

Workel, Hagma H., primary, Lubbers, Joyce M., additional, Arnold, Roland, additional, Prins, Thalina M., additional, van der Vlies, Pieter, additional, de Lange, Kim, additional, Bosse, Tjalling, additional, van Gool, Inge C., additional, Eggink, Florine A., additional, Wouters, Maartje C.A., additional, Komdeur, Fenne L., additional, van der Slikke, Elisabeth C., additional, Creutzberg, Carien L., additional, Kol, Arjan, additional, Plat, Annechien, additional, Glaire, Mark, additional, Church, David N., additional, Nijman, Hans W., additional, and de Bruyn, Marco, additional

Published
2019
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33. Transcriptome analysis suggests a compensatory role of the cofactors coenzyme A and NAD+ in medium-chain acyl-CoA dehydrogenase knockout mice

Author

LS Pathobiologie, dPB RMSC, Martines, Anne-Claire M F, Gerding, Albert, Stolle, Sarah, Vieira-Lara, Marcel A, Wolters, Justina C, Jurdzinski, Angelika, Bongiovanni, Laura, de Bruin, Alain, van der Vlies, Pieter, van der Vries, Gerben, Bloks, Vincent W, Derks, Terry G J, Reijngoud, Dirk-Jan, Bakker, Barbara M, LS Pathobiologie, dPB RMSC, Martines, Anne-Claire M F, Gerding, Albert, Stolle, Sarah, Vieira-Lara, Marcel A, Wolters, Justina C, Jurdzinski, Angelika, Bongiovanni, Laura, de Bruin, Alain, van der Vlies, Pieter, van der Vries, Gerben, Bloks, Vincent W, Derks, Terry G J, Reijngoud, Dirk-Jan, and Bakker, Barbara M

Published
2019

35. Genetic regulation ofmethylation and IL1RL1-a protein levels in asthma

Author

Dijk, F Nicole, Xu, Chengjian, Melén, Erik, Carsin, Anne-Elie, Kumar, Asish, Nolte, Ilja M, Gruzieva, Olena, Pershagen, Goran, Grotenboer, Neomi S, Savenije, Olga E M, Antó, Josep Maria, Lavi, Iris, Dobaño, Carlota, Bousquet, Jean, van der Vlies, Pieter, van der Valk, Ralf J P, de Jongste, Johan C, Nawijn, Martijn C, Guerra, Stefano, Postma, Dirkje S, Koppelman, Gerard H, Life Course Epidemiology (LCE), and Groningen Research Institute for Asthma and COPD (GRIAC)

Subjects
VARIANT FORM, CYTOKINE, AIRWAY INFLAMMATION, PROMOTER, HUMAN ST2 GENE, Journal Article, IL-33, GENOME-WIDE ASSOCIATION, RECEPTOR-LIKE 1, POLYMORPHISMS, METAANALYSIS, respiratory tract diseases
Abstract

Interleukin-1 receptor-like 1 (IL1RL1) is an important asthma gene. (Epi)genetic regulation ofIL1RL1protein expression has not been established. We assessed the association betweenIL1RL1single nucleotide polymorphisms (SNPs),IL1RL1methylation and serum IL1RL1-a protein levels, and aimed to identify causal pathways in asthma.Associations ofIL1RL1SNPs with asthma were determined in the Dutch Asthma Genome-wide Association Study cohort and three European birth cohorts, BAMSE (Children/Barn, Allergy, Milieu, Stockholm, an Epidemiological survey), INMA (Infancia y Medio Ambiente) and PIAMA (Prevention and Incidence of Asthma and Mite Allergy), participating in the Mechanisms of the Development of Allergy study. We performed blood DNAIL1RL1methylation quantitative trait locus (QTL) analysis (n=496) and (epi)genome-wide protein QTL analysis on serum IL1RL1-a levels (n=1462). We investigated the association ofIL1RL1CpG methylation with asthma (n=632) and IL1RL1-a levels (n=548), with subsequent causal inference testing. Finally, we determined the association of IL1RL1-a levels with asthma and its clinical characteristics (n=1101).IL1RL1asthma-risk SNPs strongly associated withIL1RL1methylation (rs1420101; p=3.7×10-16) and serum IL1RL1-a levels (p=2.8×10-56).IL1RL1methylation was not associated with asthma or IL1RL1-a levels. IL1RL1-a levels negatively correlated with blood eosinophil counts, whereas there was no association between IL1RL1-a levels and asthma.In conclusion, asthma-associatedIL1RL1SNPs strongly regulateIL1RL1methylation and serum IL1RL1-a levels, yet neither theseIL1RL1-methylation CpG sites nor IL1RL1-a levels are associated with asthma.

Published
2018

36. Differences in gene expression related to the results of obesity treatment, peak oxygen uptake and fatty acid metabolism measured in a cardiopulmonary exercise test

Author

Gruchała-Niedoszytko, Marta, primary, van der Vlies, Pieter, additional, Niedoszytko, Piotr, additional, Sanjabi, Bahram, additional, Niedoszytko, Marek, additional, Kaczkan, Małgorzata, additional, Pieszko, Magdalena, additional, Gierat-Haponiuk, Katarzyna, additional, Śliwińska, Aleksandra, additional, Szalewska, Dominika, additional, and Małgorzewicz, Sylwia, additional

Published
2018
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37. Genetic regulation of IL1RL1 methylation and IL1RL1-a protein levels in asthma

Author

Dijk, F. Nicole, primary, Xu, Chengjian, additional, Melén, Erik, additional, Carsin, Anne-Elie, additional, Kumar, Asish, additional, Nolte, Ilja M., additional, Gruzieva, Olena, additional, Pershagen, Goran, additional, Grotenboer, Neomi S., additional, Savenije, Olga E.M., additional, Antó, Josep Maria, additional, Lavi, Iris, additional, Dobaño, Carlota, additional, Bousquet, Jean, additional, van der Vlies, Pieter, additional, van der Valk, Ralf J.P., additional, de Jongste, Johan C., additional, Nawijn, Martijn C., additional, Guerra, Stefano, additional, Postma, Dirkje S., additional, and Koppelman, Gerard H., additional

Published
2018
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38. DNA methylation in childhood asthma : an epigenome-wide meta-analysis

Author

Xu, Cheng Jian, Söderhäll, Cilla, Bustamante, Mariona, Baïz, Nour, Gruzieva, Olena, Gehring, Ulrike, Mason, Dan, Chatzi, Leda, Basterrechea, Mikel, Llop, Sabrina, Torrent, Maties, Forastiere, Francesco, Fantini, Maria Pia, Carlsen, Karin C.Lødrup, Haahtela, Tari, Morin, Andréanne, Kerkhof, Marjan, Merid, Simon Kebede, van Rijkom, Bianca, Jankipersadsing, Soesma A., Bonder, Marc Jan, Ballereau, Stephane, Vermeulen, Cornelis J., Aguirre-Gamboa, Raul, de Jongste, Johan C., Smit, Henriette A., Kumar, Ashish, Pershagen, Göran, Guerra, Stefano, Garcia-Aymerich, Judith, Greco, Dario, Reinius, Lovisa, McEachan, Rosemary R.C., Azad, Raf, Hovland, Vegard, Mowinckel, Petter, Alenius, Harri, Fyhrquist, Nanna, Lemonnier, Nathanaël, Pellet, Johann, Auffray, Charles, van der Vlies, Pieter, van Diemen, Cleo C., Li, Yang, Wijmenga, Cisca, Netea, Mihai G., Moffatt, Miriam F., Cookson, William O.C.M., Anto, Josep M., Brunekreef, Bert, the BIOS Consortium, Xu, Cheng Jian, Söderhäll, Cilla, Bustamante, Mariona, Baïz, Nour, Gruzieva, Olena, Gehring, Ulrike, Mason, Dan, Chatzi, Leda, Basterrechea, Mikel, Llop, Sabrina, Torrent, Maties, Forastiere, Francesco, Fantini, Maria Pia, Carlsen, Karin C.Lødrup, Haahtela, Tari, Morin, Andréanne, Kerkhof, Marjan, Merid, Simon Kebede, van Rijkom, Bianca, Jankipersadsing, Soesma A., Bonder, Marc Jan, Ballereau, Stephane, Vermeulen, Cornelis J., Aguirre-Gamboa, Raul, de Jongste, Johan C., Smit, Henriette A., Kumar, Ashish, Pershagen, Göran, Guerra, Stefano, Garcia-Aymerich, Judith, Greco, Dario, Reinius, Lovisa, McEachan, Rosemary R.C., Azad, Raf, Hovland, Vegard, Mowinckel, Petter, Alenius, Harri, Fyhrquist, Nanna, Lemonnier, Nathanaël, Pellet, Johann, Auffray, Charles, van der Vlies, Pieter, van Diemen, Cleo C., Li, Yang, Wijmenga, Cisca, Netea, Mihai G., Moffatt, Miriam F., Cookson, William O.C.M., Anto, Josep M., Brunekreef, Bert, and the BIOS Consortium

Published
2018

39. DNA methylation in childhood asthma: an epigenome-wide meta-analysis

Author

One Health Chemisch, dIRAS RA-2, Xu, Cheng-Jian, Söderhäll, Cilla, Bustamante, Mariona, Baïz, Nour, Gruzieva, Olena, Gehring, Ulrike, Mason, Dan, Chatzi, Leda, Basterrechea, Mikel, Llop, Sabrina, Torrent, Maties, Forastiere, Francesco, Fantini, Maria Pia, Carlsen, Karin C Lødrup, Haahtela, Tari, Morin, Andréanne, Kerkhof, Marjan, Merid, Simon Kebede, van Rijkom, Bianca, Jankipersadsing, Soesma A, Bonder, Marc Jan, Ballereau, Stephane, Vermeulen, Cornelis J, Aguirre-Gamboa, Raul, de Jongste, Johan C, Smit, Henriette A, Kumar, Ashish, Pershagen, Göran, Guerra, Stefano, Garcia-Aymerich, Judith, Greco, Dario, Reinius, Lovisa, McEachan, Rosemary R C, Azad, Raf, Hovland, Vegard, Mowinckel, Petter, Alenius, Harri, Fyhrquist, Nanna, Lemonnier, Nathanaël, Pellet, Johann, Auffray, Charles, the BIOS Consortium, van der Vlies, Pieter, van Diemen, Cleo C, Li, Yang, Wijmenga, Cisca, Netea, Mihai G, Moffatt, Miriam F, Cookson, William O C M, Anto, Josep M, Bousquet, Jean, Laatikainen, Tiina, Laprise, Catherine, Carlsen, Kai-Hakon, Gori, Davide, Porta, Daniela, Iñiguez, Carmen, Bilbao, Jose Ramon, Kogevinas, Manolis, Wright, John, Brunekreef, Bert, Kere, Juha, Nawijn, Martijn C, Annesi-Maesano, Isabella, Sunyer, Jordi, Melén, Erik, Koppelman, Gerard H, One Health Chemisch, dIRAS RA-2, Xu, Cheng-Jian, Söderhäll, Cilla, Bustamante, Mariona, Baïz, Nour, Gruzieva, Olena, Gehring, Ulrike, Mason, Dan, Chatzi, Leda, Basterrechea, Mikel, Llop, Sabrina, Torrent, Maties, Forastiere, Francesco, Fantini, Maria Pia, Carlsen, Karin C Lødrup, Haahtela, Tari, Morin, Andréanne, Kerkhof, Marjan, Merid, Simon Kebede, van Rijkom, Bianca, Jankipersadsing, Soesma A, Bonder, Marc Jan, Ballereau, Stephane, Vermeulen, Cornelis J, Aguirre-Gamboa, Raul, de Jongste, Johan C, Smit, Henriette A, Kumar, Ashish, Pershagen, Göran, Guerra, Stefano, Garcia-Aymerich, Judith, Greco, Dario, Reinius, Lovisa, McEachan, Rosemary R C, Azad, Raf, Hovland, Vegard, Mowinckel, Petter, Alenius, Harri, Fyhrquist, Nanna, Lemonnier, Nathanaël, Pellet, Johann, Auffray, Charles, the BIOS Consortium, van der Vlies, Pieter, van Diemen, Cleo C, Li, Yang, Wijmenga, Cisca, Netea, Mihai G, Moffatt, Miriam F, Cookson, William O C M, Anto, Josep M, Bousquet, Jean, Laatikainen, Tiina, Laprise, Catherine, Carlsen, Kai-Hakon, Gori, Davide, Porta, Daniela, Iñiguez, Carmen, Bilbao, Jose Ramon, Kogevinas, Manolis, Wright, John, Brunekreef, Bert, Kere, Juha, Nawijn, Martijn C, Annesi-Maesano, Isabella, Sunyer, Jordi, Melén, Erik, and Koppelman, Gerard H

Published
2018

40. Genetic and epigenetic regulation of YKL-40 in childhood

Author

One Health Chemisch, dIRAS RA-2, Guerra, Stefano, Melén, Erik, Sunyer, Jordi, Xu, Cheng-Jian, Lavi, Iris, Benet, Marta, Bustamante, Mariona, Carsin, Anne-Elie, Dobaño, Carlota, Guxens, Mònica, Tischer, Christina, Vrijheid, Martine, Kull, Inger, Bergström, Anna, Kumar, Ashish, Söderhäll, Cilla, Gehring, Ulrike, Dijkstra, Dorieke J, van der Vlies, Pieter, Wickman, Magnus, Bousquet, Jean, Postma, Dirkje S, Anto, Josep M, Koppelman, Gerard H, One Health Chemisch, dIRAS RA-2, Guerra, Stefano, Melén, Erik, Sunyer, Jordi, Xu, Cheng-Jian, Lavi, Iris, Benet, Marta, Bustamante, Mariona, Carsin, Anne-Elie, Dobaño, Carlota, Guxens, Mònica, Tischer, Christina, Vrijheid, Martine, Kull, Inger, Bergström, Anna, Kumar, Ashish, Söderhäll, Cilla, Gehring, Ulrike, Dijkstra, Dorieke J, van der Vlies, Pieter, Wickman, Magnus, Bousquet, Jean, Postma, Dirkje S, Anto, Josep M, and Koppelman, Gerard H

Published
2018

41. DNA methylation in childhood asthma: an epigenome-wide meta-analysis

Author

Public Health Epidemiologie, Circulatory Health, Child Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten Team 3, Xu, Cheng Jian, Söderhäll, Cilla, Bustamante, Mariona, Baïz, Nour, Gruzieva, Olena, Gehring, Ulrike, Mason, Dan, Chatzi, Leda, Basterrechea, Mikel, Llop, Sabrina, Torrent, Maties, Forastiere, Francesco, Fantini, Maria Pia, Carlsen, Karin C.Lødrup, Haahtela, Tari, Morin, Andréanne, Kerkhof, Marjan, Merid, Simon Kebede, van Rijkom, Bianca, Jankipersadsing, Soesma A., Bonder, Marc Jan, Ballereau, Stephane, Vermeulen, Cornelis J., Aguirre-Gamboa, Raul, de Jongste, Johan C., Smit, Henriette A., Kumar, Ashish, Pershagen, Göran, Guerra, Stefano, Garcia-Aymerich, Judith, Greco, Dario, Reinius, Lovisa, McEachan, Rosemary R.C., Azad, Raf, Hovland, Vegard, Mowinckel, Petter, Alenius, Harri, Fyhrquist, Nanna, Lemonnier, Nathanaël, Pellet, Johann, Auffray, Charles, van der Vlies, Pieter, van Diemen, Cleo C., Li, Yang, Wijmenga, Cisca, Netea, Mihai G., Moffatt, Miriam F., Cookson, William O.C.M., Anto, Josep M., Brunekreef, Bert, the BIOS Consortium, Public Health Epidemiologie, Circulatory Health, Child Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Infectieziekten, Epi Infectieziekten Team 3, Xu, Cheng Jian, Söderhäll, Cilla, Bustamante, Mariona, Baïz, Nour, Gruzieva, Olena, Gehring, Ulrike, Mason, Dan, Chatzi, Leda, Basterrechea, Mikel, Llop, Sabrina, Torrent, Maties, Forastiere, Francesco, Fantini, Maria Pia, Carlsen, Karin C.Lødrup, Haahtela, Tari, Morin, Andréanne, Kerkhof, Marjan, Merid, Simon Kebede, van Rijkom, Bianca, Jankipersadsing, Soesma A., Bonder, Marc Jan, Ballereau, Stephane, Vermeulen, Cornelis J., Aguirre-Gamboa, Raul, de Jongste, Johan C., Smit, Henriette A., Kumar, Ashish, Pershagen, Göran, Guerra, Stefano, Garcia-Aymerich, Judith, Greco, Dario, Reinius, Lovisa, McEachan, Rosemary R.C., Azad, Raf, Hovland, Vegard, Mowinckel, Petter, Alenius, Harri, Fyhrquist, Nanna, Lemonnier, Nathanaël, Pellet, Johann, Auffray, Charles, van der Vlies, Pieter, van Diemen, Cleo C., Li, Yang, Wijmenga, Cisca, Netea, Mihai G., Moffatt, Miriam F., Cookson, William O.C.M., Anto, Josep M., Brunekreef, Bert, and the BIOS Consortium

Published
2018

42. The emerging landscape of dynamic DNA methylation in early childhood

Author

Xu, Cheng-Jian, Bonder, Marc Jan, Söderhäll, Cilla, Bustamante, Mariona, Baïz, Nour, Gehring, Ulrike, Jankipersadsing, Soesma A, Van Der Vlies, Pieter, van Diemen, Cleo C, van Rijkom, Bianca, Just, Jocelyne, Kull, Inger, Kere, Juha, Antó, Josep Maria, Bousquet, Jean, Zhernakova, Alexandra, Wijmenga, Cisca, Annesi-Maesano, Isabella, Sunyer, Jordi, Melén, Erik, Li, Yang, Postma, Dirkje S, Koppelman, Gerard H, LS IRAS EEPI ME (Milieu epidemiologie), dIRAS RA-2, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de l'Asthme et des Allergies [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Research Programs Unit, Juha Kere / Principal Investigator, LS IRAS EEPI ME (Milieu epidemiologie), dIRAS RA-2, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Translational Immunology Groningen (TRIGR), and Groningen Research Institute for Asthma and COPD (GRIAC)

Subjects
Epigenomics, 0301 basic medicine, Aging, Methylation quatitative trait loci, ADN, DISEASE, Methylation quantitative trait loci, Epigenesis, Genetic, Child Development, Pregnancy, Non-U.S. Gov't, Child, POPULATION, Maternal smoking, Genetics, DNA methylation, NEWBORNS, Research Support, Non-U.S. Gov't, Smoking, 1184 Genetics, developmental biology, physiology, Environmental exposure, Methylation, 3. Good health, D-ASPARTATE, Maternal Exposure, Child, Preschool, Prenatal Exposure Delayed Effects, Female, Metilació, PROJECT, Research Article, Infància, Biotechnology, Quantitative Trait Loci, Genomics, Quantitative trait locus, Biology, Research Support, 03 medical and health sciences, AGE, Genetic, MICROARRAY, Journal Article, Humans, Genetic Predisposition to Disease, COHORT, Epigenetics, Preschool, Gene, METAANALYSIS, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], Infant, Newborn, Genetic Variation, Infant, DNA, DNA Methylation, Newborn, Childhood, 030104 developmental biology, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, ASTHMA, CpG Islands, 3111 Biomedicine, Epigenesis, Genome-Wide Association Study
Abstract

Background: DNA methylation has been found to associate with disease, aging and environmental exposure, but it is unknown how genome, environment and disease influence DNA methylation dynamics in childhood. Results: By analysing 538 paired DNA blood samples from children at birth and at 4–5 years old and 726 paired samples from children at 4 and 8 years old from four European birth cohorts using the Illumina Infinium Human Methylation 450 k chip, we have identified 14,150 consistent age-differential methylation sites (a-DMSs) at epigenome-wide significance of p

Published
2017
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43. Running-wheel activity delays mitochondrial respiratory flux decline in aging mouse muscle via a post-transcriptional mechanism

Author

Stolle, Sarah, primary, Ciapaite, Jolita, additional, Reijne, Aaffien C., additional, Talarovicova, Alzbeta, additional, Wolters, Justina C., additional, Aguirre-Gamboa, Raúl, additional, van der Vlies, Pieter, additional, de Lange, Kim, additional, Neerincx, Pieter B., additional, van der Vries, Gerben, additional, Deelen, Patrick, additional, Swertz, Morris A., additional, Li, Yang, additional, Bischoff, Rainer, additional, Permentier, Hjalmar P., additional, Horvatovitch, Peter L., additional, Groen, Albert K., additional, van Dijk, Gertjan, additional, Reijngoud, Dirk-Jan, additional, and Bakker, Barbara M., additional

Published
2017
Full Text
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45. The emerging landscape of dynamic DNA methylation in early childhood

Author

LS IRAS EEPI ME (Milieu epidemiologie), dIRAS RA-2, Xu, Cheng-Jian, Bonder, Marc Jan, Söderhäll, Cilla, Bustamante, Mariona, Baïz, Nour, Gehring, Ulrike, Jankipersadsing, Soesma A, Van Der Vlies, Pieter, van Diemen, Cleo C, van Rijkom, Bianca, Just, Jocelyne, Kull, Inger, Kere, Juha, Antó, Josep Maria, Bousquet, Jean, Zhernakova, Alexandra, Wijmenga, Cisca, Annesi-Maesano, Isabella, Sunyer, Jordi, Melén, Erik, Li, Yang, Postma, Dirkje S, Koppelman, Gerard H, LS IRAS EEPI ME (Milieu epidemiologie), dIRAS RA-2, Xu, Cheng-Jian, Bonder, Marc Jan, Söderhäll, Cilla, Bustamante, Mariona, Baïz, Nour, Gehring, Ulrike, Jankipersadsing, Soesma A, Van Der Vlies, Pieter, van Diemen, Cleo C, van Rijkom, Bianca, Just, Jocelyne, Kull, Inger, Kere, Juha, Antó, Josep Maria, Bousquet, Jean, Zhernakova, Alexandra, Wijmenga, Cisca, Annesi-Maesano, Isabella, Sunyer, Jordi, Melén, Erik, Li, Yang, Postma, Dirkje S, and Koppelman, Gerard H

Published
2017

46. RNA Sequencing Analysis of Intracranial Aneurysm Walls Reveals Involvement of Lysosomes and Immunoglobulins in Rupture

Author

Celbiologie, Sub Cell Biology, Kleinloog, Rachel, Verweij, Bon H., Van Der Vlies, Pieter, Deelen, Patrick, Swertz, Morris A., De Muynck, Louis, Van Damme, Philip, Giuliani, Fabrizio, Regli, Luca, Van Der Zwan, Albert, Van Der Sprenkel, Jan W. Berkelbach, Han, K. Sen, Gosselaar, Peter, Van Rijen, Peter C., Korkmaz, Emine, Post, Jan A., Rinkel, Gabriel J.E., Veldink, Jan H., Ruigrok, Ynte M., Celbiologie, Sub Cell Biology, Kleinloog, Rachel, Verweij, Bon H., Van Der Vlies, Pieter, Deelen, Patrick, Swertz, Morris A., De Muynck, Louis, Van Damme, Philip, Giuliani, Fabrizio, Regli, Luca, Van Der Zwan, Albert, Van Der Sprenkel, Jan W. Berkelbach, Han, K. Sen, Gosselaar, Peter, Van Rijen, Peter C., Korkmaz, Emine, Post, Jan A., Rinkel, Gabriel J.E., Veldink, Jan H., and Ruigrok, Ynte M.

Published
2016

47. DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis

Author

dIRAS RA-2, Risk Assessment, Joubert, Bonnie R, Felix, Janine F, Yousefi, Paul, Bakulski, Kelly M, Just, Allan C, Breton, Carrie, Reese, Sarah E, Markunas, Christina A, Richmond, Rebecca C, Xu, Cheng-Jian, Küpers, Leanne K, Oh, Sam S, Hoyo, Cathrine, Gruzieva, Olena, Söderhäll, Cilla, Salas, Lucas A, Baïz, Nour, Zhang, Hongmei, Lepeule, Johanna, Ruiz, Carlos, Ligthart, Symen, Wang, Tianyuan, Taylor, Jack A, Duijts, Liesbeth, Sharp, Gemma C, Jankipersadsing, Soesma A, Nilsen, Roy M, Vaez, Ahmad, Fallin, M Daniele, Hu, Donglei, Litonjua, Augusto A, Fuemmeler, Bernard F, Huen, Karen, Kere, Juha, Kull, Inger, Munthe-Kaas, Monica Cheng, Gehring, Ulrike, Bustamante, Mariona, Saurel-Coubizolles, Marie José, Quraishi, Bilal M, Ren, Jie, Tost, Jörg, Gonzalez, Juan R, Peters, Marjolein J, Håberg, Siri E, Xu, Zongli, van Meurs, Joyce B, Gaunt, Tom R, Kerkhof, Marjan, Corpeleijn, Eva, Feinberg, Andrew P, Eng, Celeste, Baccarelli, Andrea A, Benjamin Neelon, Sara E, Bradman, Asa, Merid, Simon Kebede, Bergström, Anna, Herceg, Zdenko, Hernandez-Vargas, Hector, Brunekreef, Bert, Pinart, Mariona, Heude, Barbara, Ewart, Susan, Yao, Jin, Lemonnier, Nathanaël, Franco, Oscar H, Wu, Michael C, Hofman, Albert, McArdle, Wendy, Van der Vlies, Pieter, Falahi, Fahimeh, Gillman, Matthew W, Barcellos, Lisa F, Kumar, Ashish, Wickman, Magnus, Guerra, Stefano, Charles, Marie-Aline, Holloway, John, Auffray, Charles, Tiemeier, Henning W, Smith, George Davey, Postma, Dirkje, Hivert, Marie-France, Eskenazi, Brenda, Vrijheid, Martine, Arshad, Hasan, Antó, Josep M, Dehghan, Abbas, Karmaus, Wilfried, Annesi-Maesano, Isabella, Sunyer, Jordi, Ghantous, Akram, Pershagen, Göran, Holland, Nina, Murphy, Susan K, DeMeo, Dawn L, Burchard, Esteban G, Ladd-Acosta, Christine, Snieder, Harold, Nystad, Wenche, Koppelman, Gerard H, Relton, Caroline L, Jaddoe, Vincent W V, Wilcox, Allen, Melén, Erik, London, Stephanie J, dIRAS RA-2, Risk Assessment, Joubert, Bonnie R, Felix, Janine F, Yousefi, Paul, Bakulski, Kelly M, Just, Allan C, Breton, Carrie, Reese, Sarah E, Markunas, Christina A, Richmond, Rebecca C, Xu, Cheng-Jian, Küpers, Leanne K, Oh, Sam S, Hoyo, Cathrine, Gruzieva, Olena, Söderhäll, Cilla, Salas, Lucas A, Baïz, Nour, Zhang, Hongmei, Lepeule, Johanna, Ruiz, Carlos, Ligthart, Symen, Wang, Tianyuan, Taylor, Jack A, Duijts, Liesbeth, Sharp, Gemma C, Jankipersadsing, Soesma A, Nilsen, Roy M, Vaez, Ahmad, Fallin, M Daniele, Hu, Donglei, Litonjua, Augusto A, Fuemmeler, Bernard F, Huen, Karen, Kere, Juha, Kull, Inger, Munthe-Kaas, Monica Cheng, Gehring, Ulrike, Bustamante, Mariona, Saurel-Coubizolles, Marie José, Quraishi, Bilal M, Ren, Jie, Tost, Jörg, Gonzalez, Juan R, Peters, Marjolein J, Håberg, Siri E, Xu, Zongli, van Meurs, Joyce B, Gaunt, Tom R, Kerkhof, Marjan, Corpeleijn, Eva, Feinberg, Andrew P, Eng, Celeste, Baccarelli, Andrea A, Benjamin Neelon, Sara E, Bradman, Asa, Merid, Simon Kebede, Bergström, Anna, Herceg, Zdenko, Hernandez-Vargas, Hector, Brunekreef, Bert, Pinart, Mariona, Heude, Barbara, Ewart, Susan, Yao, Jin, Lemonnier, Nathanaël, Franco, Oscar H, Wu, Michael C, Hofman, Albert, McArdle, Wendy, Van der Vlies, Pieter, Falahi, Fahimeh, Gillman, Matthew W, Barcellos, Lisa F, Kumar, Ashish, Wickman, Magnus, Guerra, Stefano, Charles, Marie-Aline, Holloway, John, Auffray, Charles, Tiemeier, Henning W, Smith, George Davey, Postma, Dirkje, Hivert, Marie-France, Eskenazi, Brenda, Vrijheid, Martine, Arshad, Hasan, Antó, Josep M, Dehghan, Abbas, Karmaus, Wilfried, Annesi-Maesano, Isabella, Sunyer, Jordi, Ghantous, Akram, Pershagen, Göran, Holland, Nina, Murphy, Susan K, DeMeo, Dawn L, Burchard, Esteban G, Ladd-Acosta, Christine, Snieder, Harold, Nystad, Wenche, Koppelman, Gerard H, Relton, Caroline L, Jaddoe, Vincent W V, Wilcox, Allen, Melén, Erik, and London, Stephanie J

Published
2016

48. RNA Sequencing Analysis of Intracranial Aneurysm Walls Reveals Involvement of Lysosomes and Immunoglobulins in Rupture

Author

Cell Biology, Neurobiology and Biophysics, Sub Cell Biology, Kleinloog, Rachel, Verweij, Bon H., Van Der Vlies, Pieter, Deelen, Patrick, Swertz, Morris A., De Muynck, Louis, Van Damme, Philip, Giuliani, Fabrizio, Regli, Luca, Van Der Zwan, Albert, Van Der Sprenkel, Jan W. Berkelbach, Han, K. Sen, Gosselaar, Peter, Van Rijen, Peter C., Korkmaz, Emine, Post, Jan A., Rinkel, Gabriel J.E., Veldink, Jan H., Ruigrok, Ynte M., Cell Biology, Neurobiology and Biophysics, Sub Cell Biology, Kleinloog, Rachel, Verweij, Bon H., Van Der Vlies, Pieter, Deelen, Patrick, Swertz, Morris A., De Muynck, Louis, Van Damme, Philip, Giuliani, Fabrizio, Regli, Luca, Van Der Zwan, Albert, Van Der Sprenkel, Jan W. Berkelbach, Han, K. Sen, Gosselaar, Peter, Van Rijen, Peter C., Korkmaz, Emine, Post, Jan A., Rinkel, Gabriel J.E., Veldink, Jan H., and Ruigrok, Ynte M.

Published
2016

49. RNA Sequencing Analysis of Intracranial Aneurysm Walls Reveals Involvement of Lysosomes and Immunoglobulins in Rupture

Author

ZL Cerebrovasculaire Ziekten Medisch, Brain, Neurogenetica, ZL Algemene en Acute Nec Medisch, Opleiding Neurochirurgie, Zorglijn FNE Medisch, Neurologie, Circulatory Health, Hersenen-Medisch 2, ZL Neuromusculaire Ziekten Medisch, Kleinloog, Rachel, Verweij, Bon H., Van Der Vlies, Pieter, Deelen, Patrick, Swertz, Morris A., De Muynck, Louis, Van Damme, Philip, Giuliani, Fabrizio, Regli, Luca, Van Der Zwan, Albert, Van Der Sprenkel, Jan W Berkelbach, Sen Han, K., Gosselaar, Peter, Van Rijen, Peter C., Korkmaz, Emine, Post, Jan A., Rinkel, Gabriel J E, Veldink, Jan H., Ruigrok, Ynte M., ZL Cerebrovasculaire Ziekten Medisch, Brain, Neurogenetica, ZL Algemene en Acute Nec Medisch, Opleiding Neurochirurgie, Zorglijn FNE Medisch, Neurologie, Circulatory Health, Hersenen-Medisch 2, ZL Neuromusculaire Ziekten Medisch, Kleinloog, Rachel, Verweij, Bon H., Van Der Vlies, Pieter, Deelen, Patrick, Swertz, Morris A., De Muynck, Louis, Van Damme, Philip, Giuliani, Fabrizio, Regli, Luca, Van Der Zwan, Albert, Van Der Sprenkel, Jan W Berkelbach, Sen Han, K., Gosselaar, Peter, Van Rijen, Peter C., Korkmaz, Emine, Post, Jan A., Rinkel, Gabriel J E, Veldink, Jan H., and Ruigrok, Ynte M.

Published
2016

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