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2. Real-world effectiveness of the heterologous SOBERANA-02 and SOBERANA-Plus vaccine scheme in 2–11 years-old children during the SARS-CoV-2 Omicron wave in Cuba: a longitudinal case-population study

Author

Toledo-Romaní, María Eugenia, Valenzuela-Silva, Carmen, Montero-Díaz, Minerva, Iñiguez-Rojas, Luisa, Rodríguez-González, Meiby, Martínez-Cabrera, Mery, Puga-Gómez, Rinaldo, German-Almeida, Angel, Fernández-Castillo, Sonsire, Climent-Ruiz, Yanet, Santana-Mederos, Darielys, López-González, Lissette, Morales-Suárez, Ileana, Doroud, Delaram, Valdés-Balbín, Yury, García-Rivera, Dagmar, Van der Stuyft, Patrick, and Vérez-Bencomo, Vicente

Published
2024
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4. The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis

Author

Martinez, Leonardo, Cords, Olivia, Horsburgh, C Robert, Andrews, Jason R, Consortium, Pediatric TB Contact Studies, Acuna-Villaorduna, Carlos, Ahuja, Shama Desai, Altet, Neus, Augusto, Orvalho, Baliashvili, Davit, Basu, Sanjay, Becerra, Mercedes, Bonnet, Maryline, Boom, W Henry, Borgdorff, Martien, Boulahbal, Fadila, Carvalho, Anna Cristina C, Cayla, Joan A, Chakhaia, Tsira, Chan, Pei-Chun, Cohen, Ted, Croda, Julio, Datta, Sumona, del Corral, Helena, Denholm, Justin T, Dietze, Reynaldo, Dobler, Claudia C, Donkor, Simon, Egere, Uzochukwu, Ellner, Jerrold J, Espinal, Marcos, Evans, Carlton A, Fang, Chi-Tai, Fielding, Katherine, Fox, Greg J, García, Luis F, García-Basteiro, Alberto L, Geis, Steffen, Graham, Stephen M, Grandjean, Louis, Hannoun, Djohar, Hatherill, Mark, Hauri, Anja M, Hesseling, Anneke C, Hill, Philip C, Huang, Li-Min, Huerga, Helena, Hussain, Rabia, Jarlsberg, Leah, Jones-López, Edward C, Kato, Seiya, Kato-Maeda, Midori, Kampmann, Beate, Kirchner, H Lester, Kritski, Afrânio, Lange, Christoph, Lee, Chih-Hsin, Lee, Li-Na, Lee, Meng-Rui, Lemos, Antonio Carlos, Lienhardt, Christian, Ling, Du-Lin, Liu, Qiao, Lo, Nathan C, Long, Richard, Lopez-Varela, Elisa, Lu, Peng, Magee, Matthew, Malone, LaShaunda L, Mandalakas, Anna M, Martinson, Neil A, Mazahir, Rufaida, Murray, Megan B, Netto, Eduardo Martins, Otero, Larissa, Parsonnet, Julie, Reingold, Arthur, Schaaf, H Simon, Seddon, James A, Sharma, Surendra, Singh, Jitendra, Singh, Sarman, Sloot, Rosa, Sotgiu, Giovanni, Stein, Catherine M, Iqbal, Najeeha Talat, Triasih, Rina, Trieu, Lisa, van der Loeff, Maarten F Schim, Van der Stuyft, Patrick, van Schalkwyk, Cari, Vashishtha, Richa, Verhagen, Lilly M, Villalba, Julian A, Wang, Jann-Yuan, Whalen, Christopher C, Yoshiyama, Takashi, Zar, Heather J, Zellweger, Jean-Pierre, and Zhu, Limei

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Tuberculosis, Prevention, Rare Diseases, Pediatric, Infectious Diseases, Emerging Infectious Diseases, Infection, Good Health and Well Being, Adolescent, Age Factors, Child, Child, Preschool, Contact Tracing, Disease Transmission, Infectious, Family Characteristics, Female, Global Health, Humans, Incidence, Male, Mycobacterium tuberculosis, Risk Assessment, Sex Factors, Tuberculosis, Pulmonary, Pediatric TB Contact Studies Consortium, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundTens of millions of children are exposed to Mycobacterium tuberculosis globally every year; however, there are no contemporary estimates of the risk of developing tuberculosis in exposed children. The effectiveness of contact investigations and preventive therapy remains poorly understood.MethodsIn this systematic review and meta-analysis, we investigated the development of tuberculosis in children closely exposed to a tuberculosis case and followed for incident disease. We restricted our search to cohort studies published between Jan 1, 1998, and April 6, 2018, in MEDLINE, Web of Science, BIOSIS, and Embase electronic databases. Individual-participant data and a pre-specified list of variables were requested from authors of all eligible studies. These included characteristics of the exposed child, the index case, and environmental characteristics. To be eligible for inclusion in the final analysis, a dataset needed to include: (1) individuals below 19 years of age; (2) follow-up for tuberculosis for a minimum of 6 months; (3) individuals with household or close exposure to an individual with tuberculosis; (4) information on the age and sex of the child; and (5) start and end follow-up dates. Studies assessing incident tuberculosis but without dates or time of follow-up were excluded. Our analysis had two primary aims: (1) estimating the risk of developing tuberculosis by time-period of follow-up, demographics (age, region), and clinical attributes (HIV, tuberculosis infection status, previous tuberculosis); and (2) estimating the effectiveness of preventive therapy and BCG vaccination on the risk of developing tuberculosis. We estimated the odds of prevalent tuberculosis with mixed-effects logistic models and estimated adjusted hazard ratios (HRs) for incident tuberculosis with mixed-effects Poisson regression models. The effectiveness of preventive therapy against incident tuberculosis was estimated through propensity score matching. The study protocol is registered with PROSPERO (CRD42018087022).FindingsIn total, study groups from 46 cohort studies in 34 countries-29 (63%) prospective studies and 17 (37%) retrospective-agreed to share their data and were included in the final analysis. 137 647 tuberculosis-exposed children were evaluated at baseline and 130 512 children were followed for 429 538 person-years, during which 1299 prevalent and 999 incident tuberculosis cases were diagnosed. Children not receiving preventive therapy with a positive result for tuberculosis infection had significantly higher 2-year cumulative tuberculosis incidence than children with a negative result for tuberculosis infection, and this incidence was greatest among children below 5 years of age (19·0% [95% CI 8·4-37·4]). The effectiveness of preventive therapy was 63% (adjusted HR 0·37 [95% CI 0·30-0·47]) among all exposed children, and 91% (adjusted HR 0·09 [0·05-0·15]) among those with a positive result for tuberculosis infection. Among all children

Published
2020

5. Safety and efficacy of the two doses conjugated protein-based SOBERANA-02 COVID-19 vaccine and of a heterologous three-dose combination with SOBERANA-Plus: a double-blind, randomised, placebo-controlled phase 3 clinical trial

Author

Toledo-Romaní, María Eugenia, García-Carmenate, Mayra, Valenzuela-Silva, Carmen, Baldoquín-Rodríguez, Waldemar, Martínez-Pérez, Marisel, Rodríguez-González, Meiby, Paredes-Moreno, Beatriz, Mendoza-Hernández, Ivis, González-Mujica Romero, Raúl, Samón-Tabio, Oscar, Velazco-Villares, Pablo, Bacallao-Castillo, Juan Pablo, Licea-Martín, Ernesto, Rodríguez-Ortega, Misladys, Herrera-Marrero, Nuris, Caballero-González, Esperanza, Egües-Torres, Liudmila, Duartes-González, Reinaldo, García-Blanco, Serguey, Pérez-Cabrera, Suzette, Huete-Ferreira, Santos, Idalmis-Cisnero, Kirenia, Fonte-Galindo, Omayda, Meliá-Pérez, Dania, Rojas-Remedios, Ivonne, Doroud, Delaram, Gouya, Mohammad Mehdi, Biglari, Alireza, Fernández-Castillo, Sonsire, Climent-Ruiz, Yanet, Valdes-Balbín, Yury, García-Rivera, Dagmar, Van der Stuyft, Patrick, and Verez-Bencomo, Vicente

Published
2023
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8. The Potential of Surveillance Data for Dengue Risk Mapping: An Evaluation of Different Approaches in Cuba

Author

Baldoquín Rodríguez, Waldemar, primary, Mirabal, Mayelin, additional, Van der Stuyft, Patrick, additional, Gómez Padrón, Tania, additional, Fonseca, Viviana, additional, Castillo, Rosa María, additional, Monteagudo Díaz, Sonia, additional, Baetens, Jan M., additional, De Baets, Bernard, additional, Toledo Romaní, Maria Eugenia, additional, and Vanlerberghe, Veerle, additional

Published
2023
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12. Protocol for a controlled before-after quasi-experimental study to evaluate the effectiveness of a multi-component intervention to reduce gaps in hypertension care and control in low-income communes of Medellin, Colombia

Author

Londoño Agudelo, Esteban Augusto, primary, Battaglioli, Tullia, additional, Soto, Alonso, additional, Vásquez Gómez, José, additional, Aguilar Ramírez, Hernán, additional, Pérez Ospina, Viviana, additional, Rodríguez Salvá, Armando, additional, Ortiz Solórzano, Patricia, additional, Pérez, Dennis, additional, Gómez-Arias, Rubén, additional, and Van Der Stuyft, Patrick, additional

Published
2022
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20. Lung cancer occurrence after an episode of tuberculosis: a systematic review and meta-analysis

Author

Cabrera-Sanchez, Javier, Cuba, Vicente, Vega, Victor, Van der Stuyft, Patrick, and Otero Vegas, Larissa

Subjects
Humans, Lung Neoplasms/diagnosis/epidemiology, Prospective Studies, Environmental Exposure, Tuberculosis, Retrospective Studies
Abstract

INTRODUCTION: People with tuberculosis experience long-term health effects beyond cure, including chronic respiratory diseases. We investigated whether tuberculosis is a risk factor for subsequent lung cancer. METHODS: We searched PubMed, Scopus, Cochrane, Latin American and Caribbean Health Sciences Literature and the Scientific Electronic Library Online for cohort and case-control studies providing effect estimates for the association between tuberculosis and subsequent lung cancer. We pooled estimates through random-effects meta-analysis. The study was registered in PROSPERO (CDR42020178362). RESULTS: Out of 6240 records, we included 29 cohort and 44 case-control studies. Pooled estimates adjusted for age and smoking (assessed quantitatively) were hazard ratio (HR) 1.51 (95% CI 1.30-1.76, I(2)=81%; five studies) and OR 1.74 (95% CI 1.42-2.13, I(2)=59%; 19 studies). The occurrence of lung cancer was increased for 2 years after tuberculosis diagnosis (HR 5.01, 95% CI 3.64-6.89; two studies), but decreased thereafter. Most studies were retrospective, had moderate to high risk of bias, and did not control for passive smoking, environmental exposure and socioeconomic status. Heterogeneity was high. CONCLUSION: We document an association between tuberculosis and lung cancer occurrence, particularly in, but not limited to, the first 2 years after tuberculosis diagnosis. Some cancer cases may have been present at the time of tuberculosis diagnosis and therefore causality cannot be ascertained. Prospective studies controlling for key confounding factors are needed to identify which tuberculosis patients are at the highest risk, as well as cost-effective approaches to mitigate such risk.

Published
2022

22. Safety and Efficacy of the Two Doses Conjugated Protein-Based SOBERANA-02 COVID-19 Vaccine and of a Heterologous Three-Dose Combination with SOBERANA-PLUS: Double-Blind, Randomised, Placebo-Controlled Phase 3 Clinical Trial

Author

Eugenia-Toledo-Romani, Maria, primary, García Carmenate, Mayra, additional, Valenzuela-Silva, Carmen, additional, Baldoquín-Rodríguez, Waldemar, additional, Martínez-Pérez, Marisel, additional, Rodriguez-González, Meiby, additional, Paredes-Moreno, Beatriz, additional, Mendoza-Hernández, Ivis, additional, González-Mugica, Raul, additional, Samón-Tabío, Oscar, additional, Velazco-Villares, Pablo, additional, Bacallao-Castillo, Juan Pablo, additional, Licea-Martín, Ernesto, additional, Rodríguez-Ortega, Misladys, additional, Herrera-Marrero, Nuris, additional, Caballero-González, Esperanza, additional, Egües-Torres, Liudmila, additional, Duartes-González, Reinaldo, additional, García-Blanco, Serguey, additional, Pérez-Cabrera, Suzette Pérez-Cabrera, additional, Huete-Ferreira, Santos, additional, Idalmis-Cisnero, Kirenia Idalmis-Cisnero, additional, Fonte-Galindo, Omayda, additional, Melia-Pérez, Dania, additional, Rojas-Remedios, Ivonne, additional, Doroud, Delaram, additional, Mehdi Gouya, Mohammad, additional, Biglari, Alireza, additional, Van der Stuyft, Patrick Van der Stuyft, additional, Fernandez-Castillo, Sonsire, additional, Climent-Ruiz, Yanet, additional, Valdés-Balbín, Yury, additional, García-Rivera, Dagmar, additional, and Verez-Bencomo, Vicente, additional

Published
2022
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36. Participación comunitaria en la prevención del dengue: un abordaje desde la perspectiva de los diferentes actores sociales

Author

Toledo-Romaní María Eugenia, Baly-Gil Alberto, Ceballos-Ursula Enrique, Boelaert Marleen, and Van der Stuyft Patrick

Subjects
participación comunitaria, dengue, Aedes aegypti, actores sociales, Cuba, Public aspects of medicine, RA1-1270
Abstract

OBJETIVO: explorar las percepciones sobre la participación comunitaria en la prevención del dengue durante la investigación formativa de un proyecto comunitario. MATERIAL Y MÉTODOS: Estudio conducido en tres áreas de salud de Santiago de Cuba durante el año 2000. Se combinan técnicas cualitativas y cuantitativas para explorar opiniones de los profesionales de salud, líderes comunitarios y una muestra aleatoria de población. RESULTADOS: Los profesionales identifican la no participación de la comunidad y sus propias limitaciones para involucrarla activamente en la prevención. Los líderes refieren falta de motivación, y la población vincula la eliminación del vector con el uso de tecnologías. Se perciben barreras en la aceptación de las actividades del programa de control y en general la "participación" es interpretada como "colaboración". CONCLUSIONES: La población ha trasferido responsabilidad del control del Aedes aegypti al sector salud. Se evidencia la necesidad de unificar conceptos sobre la participación comunitaria y conciliar intereses entre usuarios y proveedores de los servicios para lograr una real movilización social.

Published
2006

42. Recurrent TB: a systematic review and meta-analysis of the incidence rates and the proportions of relapses and reinfections

Author

Vega, Victor, Rodríguez, Sharon, Van der Stuyft, Patrick, Seas Ramos, Carlos Rafael, and Otero Vegas, Larissa

Subjects
tuberculosis, respiratory infection, purl.org/pe-repo/ocde/ford#3.02.07 [https], clinical epidemiology
Abstract

BACKGROUND: A recurrent tuberculosis (TB) episode results from exogenous reinfection or relapse after cure. The use of genotyping allows the distinction between both. METHODS: We did a systematic review and meta-analysis, using four databases to search for studies in English, French and Spanish published between 1 January 1980 and 30 September 2020 that assessed recurrences after TB treatment success and/or differentiated relapses from reinfections using genotyping. We calculated person years of follow-up and performed random-effects model meta-analysis for estimating pooled recurrent TB incidence rates and proportions of relapses and reinfections. We performed subgroup analyses by clinical-epidemiological factors and by methodological study characteristics. FINDINGS: The pooled recurrent TB incidence rate was 2.26 per 100 person years at risk (95% CI 1.87 to 2.73; 145 studies). Heterogeneity was high (I(2)=98%). Stratified pooled recurrence rates increased from 1.47 (95% CI 0.87 to 2.46) to 4.10 (95% CI 2.67 to 6.28) per 100 person years for studies conducted in low versus high TB incidence settings. Background HIV prevalence, treatment drug regimen, sample size and duration of follow-up contributed too. The pooled proportion of relapses was 70% (95% CI 63% to 77%; I²=85%; 48 studies). Heterogeneity was determined by background TB incidence, as demonstrated by pooled proportions of 83% (95% CI 75% to 89%) versus 59% (95% CI 42% to 74%) relapse for studies from settings with low versus high TB incidence, respectively. INTERPRETATION: The risk of recurrent TB is substantial and relapse is consistently the most frequent form of recurrence. Notwithstanding, with increasing background TB incidence the proportion of reinfections increases and the predominance of relapses among recurrences decreases.

Published
2021

47. Brote epidémico de denguevirus 2, genotipo Jamaica, en Bolivia

Author

Gianella Alberto, Pirard Marianne, Holzman Anaí, Boelaert Marleen, Fernández-Ortiz Frank, Peredo Carlos, Pelegrino José Luis, and Van der Stuyft Patrick

Subjects
dengue, Bolivia, Public aspects of medicine, RA1-1270
Abstract

Objetivo. Confirmar la presencia de brote de dengue en la ciudad de Santa Cruz, Bolivia, así como identificar el denguevirus causal, estimar la tasa de ataque y determinar la proporción de infecciones sintomáticas. Material y métodos. En marzo de 1997 se realizó una encuesta seroepidemiológica con muestreo aleatorio en un distrito céntrico de la ciudad. Se obtuvo información sobre episodios de enfermedad aguda, antecedentes de cuadro febril reciente y muestras de sangre venosa. Se determinó la presencia de IgM antidengue con el método MAC ELISA y se procedió a la tipificación del virus con tecnología de reacción en cadena de la polimerasa. Resultados. Se detectaron anticuerpos IgM en 6.5% de los adultos (IC95% 3.4-9.6) y 5.1% de los niños (IC 95% 2.0-8.2). El virus circulante fue identificado como dengue serotipo 2, genotipo Jamaica. Menos de la mitad de los niños infectados tuvieron una infección sintomática, contra casi 90% de los adultos. Conclusiones. La tasa de ataque estimada es compatible con una epidemia de dengue en Santa Cruz. La introducción del serotipo 2 - Jamaica en el país aumenta el riesgo de dengue hemorrágico.

Published
1998

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