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530 results on '"Van de Wiele, C."'

18. 68Ga-citrate PET/CT in tuberculosis: a pilot study

Author

Alex Maes, Van De Wiele C, Mariza Vorster, and Mike Sathekge

Subjects
Adult, Male, medicine.medical_specialty, Treatment response, Tuberculosis, Gallium, Pilot Projects, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Positron Emission Tomography Computed Tomography, medicine, Humans, Radiology, Nuclear Medicine and imaging, Citrates, Lymph node, PET-CT, Gastrointestinal tract, Lung, business.industry, Middle Aged, medicine.disease, medicine.anatomical_structure, Female, Histopathology, Radiology, business, 68Ga-Citrate
Abstract

BACKGROUND: Tuberculosis remains an important cause of morbidity and mortality worldwide, the diagnosis, staging and treatment response evaluation of which remains sub-optimal. We evaluated PET/CT imaging with a novel tracer, 68Ga-citrate, in this setting. METHODS: Thirteen patients with tuberculosis underwent PET/CT imaging with 68Ga-citrate. Tuberculosis was diagnosed with bacteriological or histopathology studies (N.=8) or based on a combination of clinical data, biochemistry and imaging (N.=5). PET images were analyzed qualitatively and semi-quantitatively and compared to CT findings. RESULTS: All 13 patients demonstrated abnormal tracer accumulation in the lungs or extra-pulmonary or both. 68Ga-citrate accumulated in every lung lesion noted on CT in six cases (46%). In seven cases (54%) some of the lung lesions noted on CT were not 68Ga-citrate avid, which is suggestive of non-active tuberculous lesions. Ten patients (77%) demonstrated extrapulmonary involvement, which included various lymph node groups, skeletal lesions, pleural-, splenic- and gastrointestinal tract involvement. Detection of extra-pulmonary involvement was higher on PET compared to CT (more lesions detected) in eight cases (80%). CONCLUSIONS: 68Ga-citrate PET accumulates in both pulmonary and extra-pulmonary tuberculous lesions and may provide a way of distinguishing active from inactive lesions for treatment response evaluation. 68Ga-citrate PET may be superior to CT in the detection of extrapulmonary involvement. ispartof: Quarterly Journal of Nuclear Medicine and Molecular Imaging vol:63 issue:1 pages:48-55 ispartof: location:Italy status: published

Published
2019
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19. EDITORIAL

Author

Van de Wiele, C, Rottey, S, Goethals, I, Buscombe, J, Van Belle, S, De Vos, F, and Dierckx, R A

Published
2003

26. EDITORIAL

Author

GOETHALS, I., DIERCKX, R., VAN LAERE, K., VAN DE WIELE, C., and SIGNORE, A.

Published
2002

37. Ten-Color flow cytometry reveals distinct patterns of expression of CD124 and CD126 by developing thymocytes

Author

Marino Julie H, Coburn Matthew Z, Taylor Ashlee A, Tan Chibing, Van De Wiele C Justin, and Teague T Kent

Subjects
Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Background We have developed a 12-parameter/10-color flow cytometric staining method for the simultaneous detection and characterization of 21 mouse thymocyte subpopulations that represent discreet stages of T cell development. To demonstrate the utility of this method, we assessed cytokine receptor expression on mouse thymocyte subsets. These experiments revealed distinct patterns of surface expression of receptors for the cytokines IL-4 and IL-6. Results The IL-4 receptor α chain (CD124) was highly expressed on the earliest thymocyte subsets, then downregulated prior to T cell receptor β-selection and finally upregulated in the CD4/CD8 double positive cells prior to positive selection. The IL-6 receptor α chain (CD126) showed a different pattern of expression. It was expressed on the most mature subsets within the CD4 and CD8 single positive (SP) compartments and was absent on all other thymocytes with the exception of a very small cKit-CD4-CD8- population. Intracellular staining of SP thymocytes for phosphorylated STAT-1 demonstrated that IL-6 signaling was confined to the most mature SP subsets. Conclusions This 12-parameter staining methodology uses only commercially available fluorochrome-coupled monoclonal antibodies and therefore could be employed by any investigator with access to a 4-laser flow cytometer. This novel staining scheme allowed us to easily phenotype thymocyte subpopulations that span across development, from the early thymic progenitors (ETPs) to the most mature subsets of the CD4 and CD8 single positive populations.

Published
2011
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41. J.P. Van Haelst

Author

Van de Wiele, C., Philippé, J., Damme, J. Van, Thierens, H., Leroux-Roels, G. E., and Dierckx, R. A.

Published
1997

45. PRRT dosimetry

Author

Konijnenberg, Mark, Hubalewska-Dydejczyk, A, Signore, A, de Jong, M., Dierckx, RA, Buscombe, J, van de Wiele, C., and Radiology & Nuclear Medicine

Published
2015

47. Somatostatin analogues and radionuclides used in therapy

Author

Vliet, Esther, Kam, BLR, Teunissen, Jaap, Jong, Marion, Krenning, Eric, Kwekkeboom, Dik, Hubalewska-Dydejczyk, A, Signore, A, de Jong, M., Dierckx, RA, Buscombe, J, van de Wiele, C, and Radiology & Nuclear Medicine

Published
2015

48. EDITORIAL

Author

Van De Wiele C, Ingeborg Goethals, Van Laere K, Rudi Dierckx, and Alberto Signore

Subjects
Pathology, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Computed tomography, General Medicine, medicine.disease, Proton mr spectroscopy, Chronic subdural hematoma, Nuclear medicine imaging, medicine, Radiology, Nuclear Medicine and imaging, Radionuclide imaging, Bacterial meningitis, Differential diagnosis, business, Brain abscess
Published
2002
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49. Age- and sex-related 99Tcm-DMSA renal uptake at 24 h in children with a normal scintigram

Author

De Sutter J, Van De Wiele C, R. A. J. O. Dierckx, Van de Walle J, Karel Everaert, and M. Simons

Subjects
Male, Aging, medicine.medical_specialty, Pediatrics, Adolescent, Urinary system, Group ii, Normal values, Kidney, Scintigraphy, Age and sex, Gastroenterology, Reference Values, Internal medicine, medicine, Humans, Tissue Distribution, Radiology, Nuclear Medicine and imaging, Child, Radionuclide Imaging, Renal uptake, Retrospective Studies, Sex Characteristics, medicine.diagnostic_test, business.industry, Age Factors, Infant, Biological Transport, General Medicine, El Niño, Child, Preschool, Technetium Tc 99m Dimercaptosuccinic Acid, Female, Radiopharmaceuticals, business, Normal kidneys
Abstract

We performed a retrospective study to determine the age- and sex-related normal values of absolute 99Tcm-DMSA uptake at 24 h in children with normal kidneys. Of the 576 scintigrams performed between 1993 and 1996, 136 (272 kidneys) were classified as 'normal' by two independent observers on the basis of the presence of a smooth cortical outline, the absence of cortical loss, relative uptake in the range 45-55% and normal echographic parenchymal findings. The 136 scintigrams were divided into eight groups based on the children's age: Group I, < 1 month (2 boys); Group II, 1-3 months (6 boys, 8 girls); Group III, 4-7 months (7 boys, 6 girls); Group IV, 8-12 months (8 boys, 8 girls); Group V, 13-24 months (14 boys, 4 girls); Group VI, 25-36 months (6 boys, 13 girls); Group VII, 37-120 months (13 boys, 19 girls); Group VIII, 121-180 months (8 boys, 10 girls). In contrast to the results of Morris et al. using absolute 99Tcm-DMSA uptake at 4-6 h, we found that combined left and right kidney uptake increased until age 8 months (Group I, 22.0 +/- 6.7%; Group II, 45.9 +/- 5.0%; Group III, 50.8 +/- 5.0%; Group IV, 56.9 +/- 8.5%; P = 0.019), after which it reached a plateau (Group V, 55.4 +/- 7.3%; Group VI, 60.1 +/- 7.8%; Group VII, 62.0 +/- 5.0%; Group VIII, 62.4 +/- 6.3%). Uptake at 24 h tended to be lower in the girls than in the boys, but this difference was not significant.

Published
1998
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