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194 results on '"Van Velzen A. S."'

1. ENIGMA-DTI: Translating reproducible white matter deficits into personalized vulnerability metrics in cross-diagnostic psychiatric research.

Author

Kochunov, Peter, Hong, L Elliot, Dennis, Emily L, Morey, Rajendra A, Tate, David F, Wilde, Elisabeth A, Logue, Mark, Kelly, Sinead, Donohoe, Gary, Favre, Pauline, Houenou, Josselin, Ching, Christopher RK, Holleran, Laurena, Andreassen, Ole A, van Velzen, Laura S, Schmaal, Lianne, Villalón-Reina, Julio E, Bearden, Carrie E, Piras, Fabrizio, Spalletta, Gianfranco, van den Heuvel, Odile A, Veltman, Dick J, Stein, Dan J, Ryan, Meghann C, Tan, Yunlong, van Erp, Theo GM, Turner, Jessica A, Haddad, Liz, Nir, Talia M, Glahn, David C, Thompson, Paul M, and Jahanshad, Neda

Subjects
Humans, Mental Disorders, Psychiatry, Biomedical Research, Multicenter Studies as Topic, Diffusion Tensor Imaging, White Matter, DTI, ENIGMA, RVI, big data, cross-disorder, white matter deficit patterns, Serious Mental Illness, Schizophrenia, Biomedical Imaging, Prevention, Mental Health, Genetics, Clinical Research, Brain Disorders, Neurosciences, Depression, 2.1 Biological and endogenous factors, Mental health, Cognitive Sciences, Experimental Psychology
Abstract

The ENIGMA-DTI (diffusion tensor imaging) workgroup supports analyses that examine the effects of psychiatric, neurological, and developmental disorders on the white matter pathways of the human brain, as well as the effects of normal variation and its genetic associations. The seven ENIGMA disorder-oriented working groups used the ENIGMA-DTI workflow to derive patterns of deficits using coherent and coordinated analyses that model the disease effects across cohorts worldwide. This yielded the largest studies detailing patterns of white matter deficits in schizophrenia spectrum disorder (SSD), bipolar disorder (BD), major depressive disorder (MDD), obsessive-compulsive disorder (OCD), posttraumatic stress disorder (PTSD), traumatic brain injury (TBI), and 22q11 deletion syndrome. These deficit patterns are informative of the underlying neurobiology and reproducible in independent cohorts. We reviewed these findings, demonstrated their reproducibility in independent cohorts, and compared the deficit patterns across illnesses. We discussed translating ENIGMA-defined deficit patterns on the level of individual subjects using a metric called the regional vulnerability index (RVI), a correlation of an individual's brain metrics with the expected pattern for a disorder. We discussed the similarity in white matter deficit patterns among SSD, BD, MDD, and OCD and provided a rationale for using this index in cross-diagnostic neuropsychiatric research. We also discussed the difference in deficit patterns between idiopathic schizophrenia and 22q11 deletion syndrome, which is used as a developmental and genetic model of schizophrenia. Together, these findings highlight the importance of collaborative large-scale research to provide robust and reproducible effects that offer insights into individual vulnerability and cross-diagnosis features.

Published
2022

3. Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group

Author

Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Amod, Alyssa R., Laansma, Max A., Van Velzen, Laura S., Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Blair, James R., Blair, Karina S., Hirsch, Joy, Pantazatos, Spiro P., Schneier, Franklin R., Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R. K., Thomopoulos, Sophia I., Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C., Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P. Michiel, Heeren, Alexandre, Cremers, Henk R., Hofmann, David, Straube, Thomas, Doruyter, Alexander G. G., Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Filippi, Courtney A., Gold, Andrea L., Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J., Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J., Sindermann, Lisa, Ball, Tali M., Fonzo, Gregory A., Paulus, Martin P., Simmons, Alan, Stein, Murray B., Klumpp, Heide, Phan, K. Luan, Furmark, Tomas, Månsson, Kristoffer N. T., Manzouri, Amirhossein, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Feola, Brandee, Harper, Jennifer C., Sylvester, Chad M., Lueken, Ulrike, Veltman, Dick J., Winkler, Anderson M., Jahanshad, Neda, Pine, Daniel S., Thompson, Paul M., Stein, Dan J., and Van der Wee, Nic J. A.

Published
2023
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5. Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium

Author

van Velzen, Laura S., Dauvermann, Maria R., Colic, Lejla, Villa, Luca M., Savage, Hannah S., Toenders, Yara J., Zhu, Alyssa H., Bright, Joanna K., Campos, Adrián I., Salminen, Lauren E., Ambrogi, Sonia, Ayesa-Arriola, Rosa, Banaj, Nerisa, Başgöze, Zeynep, Bauer, Jochen, Blair, Karina, Blair, Robert James, Brosch, Katharina, Cheng, Yuqi, Colle, Romain, Connolly, Colm G., Corruble, Emmanuelle, Couvy-Duchesne, Baptiste, Crespo-Facorro, Benedicto, Cullen, Kathryn R., Dannlowski, Udo, Davey, Christopher G., Dohm, Katharina, Fullerton, Janice M., Gonul, Ali Saffet, Gotlib, Ian H., Grotegerd, Dominik, Hahn, Tim, Harrison, Ben J., He, Mengxin, Hickie, Ian B., Ho, Tiffany C., Iorfino, Frank, Jansen, Andreas, Jollant, Fabrice, Kircher, Tilo, Klimes-Dougan, Bonnie, Klug, Melissa, Leehr, Elisabeth J., Lippard, Elizabeth T. C., McLaughlin, Katie A., Meinert, Susanne, Miller, Adam Bryant, Mitchell, Philip B., Mwangi, Benson, Nenadić, Igor, Ojha, Amar, Overs, Bronwyn J., Pfarr, Julia-Katharina, Piras, Fabrizio, Ringwald, Kai G., Roberts, Gloria, Romer, Georg, Sanches, Marsal, Sheridan, Margaret A., Soares, Jair C., Spalletta, Gianfranco, Stein, Frederike, Teresi, Giana I., Tordesillas-Gutiérrez, Diana, Uyar-Demir, Aslihan, van der Wee, Nic J. A., van der Werff, Steven J., Vermeiren, Robert R. J. M., Winter, Alexandra, Wu, Mon-Ju, Yang, Tony T., Thompson, Paul M., Rentería, Miguel E., Jahanshad, Neda, Blumberg, Hilary P., van Harmelen, Anne-Laura, and Schmaal, Lianne

Published
2022
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7. Treatment‐related risk factors for inhibitor development in non‐severe hemophilia A after 50 cumulative exposure days: A case‐control study

Author

Abdi, Amal, Eckhardt, Corien L., van Velzen, Alice S., Vuong, Caroline, Coppens, Michiel, Castaman, Giancarlo, Hart, Dan P., Hermans, Cedric, Laros‐van Gorkom, Britta, Leebeek, Frank W.G., Mancuso, Maria Elisa, Mazzucconi, Maria G., McRae, Simon, Oldenburg, Johannes, Male, Christoph, van der Bom, Johanna G., Fijnvandraat, Karin, and Gouw, Samantha C.

Published
2021
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8. Heritability and reliability of automatically segmented human hippocampal formation subregions

Author

Whelan, Christopher D, Hibar, Derrek P, van Velzen, Laura S, Zannas, Anthony S, Carrillo-Roa, Tania, McMahon, Katie, Prasad, Gautam, Kelly, Sinéad, Faskowitz, Joshua, deZubiracay, Greig, Iglesias, Juan E, van Erp, Theo GM, Frodl, Thomas, Martin, Nicholas G, Wright, Margaret J, Jahanshad, Neda, Schmaal, Lianne, Sämann, Philipp G, Thompson, Paul M, and Initiative, for the Alzheimer's Disease Neuroimaging

Subjects
Biomedical and Clinical Sciences, Health Sciences, Acquired Cognitive Impairment, Clinical Research, Neurosciences, Brain Disorders, Mental Health, Biomedical Imaging, Aging, 2.1 Biological and endogenous factors, Aetiology, Neurological, Mental health, Good Health and Well Being, Adult, Aged, Aged, 80 and over, Algorithms, Alzheimer Disease, Anxiety Disorders, Depressive Disorder, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neuroimaging, Phenotype, Software, Alzheimer's Disease Neuroimaging Initiative, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery, Biomedical and clinical sciences, Health sciences
Abstract

The human hippocampal formation can be divided into a set of cytoarchitecturally and functionally distinct subregions, involved in different aspects of memory formation. Neuroanatomical disruptions within these subregions are associated with several debilitating brain disorders including Alzheimer's disease, major depression, schizophrenia, and bipolar disorder. Multi-center brain imaging consortia, such as the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) consortium, are interested in studying disease effects on these subregions, and in the genetic factors that affect them. For large-scale studies, automated extraction and subsequent genomic association studies of these hippocampal subregion measures may provide additional insight. Here, we evaluated the test-retest reliability and transplatform reliability (1.5T versus 3T) of the subregion segmentation module in the FreeSurfer software package using three independent cohorts of healthy adults, one young (Queensland Twins Imaging Study, N=39), another elderly (Alzheimer's Disease Neuroimaging Initiative, ADNI-2, N=163) and another mixed cohort of healthy and depressed participants (Max Planck Institute, MPIP, N=598). We also investigated agreement between the most recent version of this algorithm (v6.0) and an older version (v5.3), again using the ADNI-2 and MPIP cohorts in addition to a sample from the Netherlands Study for Depression and Anxiety (NESDA) (N=221). Finally, we estimated the heritability (h(2)) of the segmented subregion volumes using the full sample of young, healthy QTIM twins (N=728). Test-retest reliability was high for all twelve subregions in the 3T ADNI-2 sample (intraclass correlation coefficient (ICC)=0.70-0.97) and moderate-to-high in the 4T QTIM sample (ICC=0.5-0.89). Transplatform reliability was strong for eleven of the twelve subregions (ICC=0.66-0.96); however, the hippocampal fissure was not consistently reconstructed across 1.5T and 3T field strengths (ICC=0.47-0.57). Between-version agreement was moderate for the hippocampal tail, subiculum and presubiculum (ICC=0.78-0.84; Dice Similarity Coefficient (DSC)=0.55-0.70), and poor for all other subregions (ICC=0.34-0.81; DSC=0.28-0.51). All hippocampal subregion volumes were highly heritable (h(2)=0.67-0.91). Our findings indicate that eleven of the twelve human hippocampal subregions segmented using FreeSurfer version 6.0 may serve as reliable and informative quantitative phenotypes for future multi-site imaging genetics initiatives such as those of the ENIGMA consortium.

Published
2016

9. White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group

Author

van Velzen, Laura S., Kelly, Sinead, Isaev, Dmitry, Aleman, Andre, Aftanas, Lyubomir I., Bauer, Jochen, Baune, Bernhard T., Brak, Ivan V., Carballedo, Angela, Connolly, Colm G., Couvy-Duchesne, Baptiste, Cullen, Kathryn R., Danilenko, Konstantin V., Dannlowski, Udo, Enneking, Verena, Filimonova, Elena, Förster, Katharina, Frodl, Thomas, Gotlib, Ian H., Groenewold, Nynke A., Grotegerd, Dominik, Harris, Mathew A., Hatton, Sean N., Hawkins, Emma L., Hickie, Ian B., Ho, Tiffany C., Jansen, Andreas, Kircher, Tilo, Klimes-Dougan, Bonnie, Kochunov, Peter, Krug, Axel, Lagopoulos, Jim, Lee, Renick, Lett, Tristram A., Li, Meng, MacMaster, Frank P., Martin, Nicholas G., McIntosh, Andrew M., McLellan, Quinn, Meinert, Susanne, Nenadić, Igor, Osipov, Evgeny, Penninx, Brenda W. J. H., Portella, Maria J., Repple, Jonathan, Roos, Annerine, Sacchet, Matthew D., Sämann, Philipp G., Schnell, Knut, Shen, Xueyi, Sim, Kang, Stein, Dan J., van Tol, Marie-Jose, Tomyshev, Alexander S., Tozzi, Leonardo, Veer, Ilya M., Vermeiren, Robert, Vives-Gilabert, Yolanda, Walter, Henrik, Walter, Martin, van der Wee, Nic J. A., van der Werff, Steven J. A., Schreiner, Melinda Westlund, Whalley, Heather C., Wright, Margaret J., Yang, Tony T., Zhu, Alyssa, Veltman, Dick J., Thompson, Paul M., Jahanshad, Neda, and Schmaal, Lianne

Published
2020
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11. ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing

Author

Schmaal, Lianne, Pozzi, Elena, C. Ho, Tiffany, van Velzen, Laura S., Veer, Ilya M., Opel, Nils, Van Someren, Eus J. W., Han, Laura K. M., Aftanas, Lybomir, Aleman, André, Baune, Bernhard T., Berger, Klaus, Blanken, Tessa F., Capitão, Liliana, Couvy-Duchesne, Baptiste, R. Cullen, Kathryn, Dannlowski, Udo, Davey, Christopher, Erwin-Grabner, Tracy, Evans, Jennifer, Frodl, Thomas, Fu, Cynthia H. Y., Godlewska, Beata, Gotlib, Ian H., Goya-Maldonado, Roberto, Grabe, Hans J., Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Gutman, Boris A., Hall, Geoffrey B., Harrison, Ben J., Hatton, Sean N., Hermesdorf, Marco, Hickie, Ian B., Hilland, Eva, Irungu, Benson, Jonassen, Rune, Kelly, Sinead, Kircher, Tilo, Klimes-Dougan, Bonnie, Krug, Axel, Landrø, Nils Inge, Lagopoulos, Jim, Leerssen, Jeanne, Li, Meng, Linden, David E. J., MacMaster, Frank P., M. McIntosh, Andrew, Mehler, David M. A., Nenadić, Igor, Penninx, Brenda W. J. H., Portella, Maria J., Reneman, Liesbeth, Rentería, Miguel E., Sacchet, Matthew D., G. Sämann, Philipp, Schrantee, Anouk, Sim, Kang, Soares, Jair C., Stein, Dan J., Tozzi, Leonardo, van Der Wee, Nic J. A., van Tol, Marie-José, Vermeiren, Robert, Vives-Gilabert, Yolanda, Walter, Henrik, Walter, Martin, Whalley, Heather C., Wittfeld, Katharina, Whittle, Sarah, Wright, Margaret J., Yang, Tony T., Zarate, Jr, Carlos, Thomopoulos, Sophia I., Jahanshad, Neda, Thompson, Paul M., and Veltman, Dick J.

Published
2020
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15. The impact of depression and anxiety treatment on biological aging and metabolic stress: study protocol of the Mood treatment with antidepressants or running (MOTAR) study

Author

Lever-van Milligen, Bianca A., Verhoeven, Josine E., Schmaal, Lianne, van Velzen, Laura S., Révész, Dóra, Black, Catherine N., Han, Laura K. M., Horsfall, Melany, Batelaan, Neeltje M., van Balkom, Anton J. L. M., van Schaik, Digna J. F., van Oppen, Patricia, and Penninx, Brenda W. J. H.

Published
2019
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16. Urgent call for research into imagery rescripting to reduce suicidal mental imagery: clinical research considerations.

Author

Paulik, Georgie, Van Velzen, Laura S., Lee, Christopher W., Markulev, Connie, Jackson Simpson, Jennifer, Davies, Pemma, Bendall, Sarah, and Schmaal, Lianne

Subjects
*EDUCATION of physicians, *TREATMENT effectiveness, *CLINICAL supervision, *MENTAL depression, *VISUALIZATION, *BIPOLAR disorder, *COGNITIVE therapy
Abstract

Dysfunctional mental imagery is integral to the maintenance of many psychological disorders and is typically associated with stronger affective and behavioural responses than verbal cognitions. This finding extends itself to the high prevalence of suicidal mental imagery in disorders such as depression and bipolar disorder. Imagery Rescripting is a therapy approach which has been found to effectively reduce dysfunctional mental images across various mental health conditions. Thus, Imagery Rescripting of suicidal mental imagery may be effective at reducing such cognitions and ultimately associated risk. However, this remains an unexplored area within the treatment literature. This paper puts out an urgent call for clinical research to evaluate the effectiveness of such a treatment intervention, and to assist, we propose and describe a clinical approach to this to stimulate further thought and research. There are also many research questions of clinical relevance that must be explored in this field of work, which we put forward and consider in this commentary piece. What is already known about this topic: Mental imagery is a form of cognition that generates stronger emotional responses compared to verbal-linguistic thinking and is integral to the maintenance of most psychological disorders. Cognitive Behavioural Therapy (CBT) approaches are typically more effective when mental imagery techniques – such as Imagery Rescripting (ImRs) – are incorporated to target intrusive, distressing mental imagery. Mental images of suicide (comprised of both flash-back and/or flash-forward mental images) are more distressing, realistic and promote suicidal behaviours more than verbal thoughts, and are common in disorders such as depression and bipolar disorder. What this topic adds: Urgent clinical research is needed to evaluate the effectiveness of ImRs at reducing intrusive suicidal mental images, and thus related risk, and this paper proposes and describes an approach for researchers to use as a framework. There are several clinical research considerations to be made when examining ImRs of suicidal mental images, including around the delivery and safety of the intervention. More research is needed to clarify the above clinical considerations, and to further understand change mechanisms, to learn the most safe and effective ImRs approach. If ImRs is found to be effective at reducing suicidal images in upcoming clinical trials, it is strongly recommended clinicians receive adequate training and ongoing clinical supervision from an experienced practitioner given the complexities around this approach. [ABSTRACT FROM AUTHOR]

Published
2024
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18. 39. Subcortical Brain Volumes in Social Anxiety Disorder: An Enigma-Anxiety International Mega-Analysis of 37 Samples

Author

Bas-Hoogendam, Janna Marie, primary, Groenewold, Nynke A., additional, Amod, Alyssa R., additional, Laansma, Max A., additional, van Velzen, Laura S., additional, Aghajani, Moji, additional, Hilbert, Kevin, additional, Ching, Christopher R.K., additional, Thomopoulos, Sophia I., additional, Working Group members, Enigma-Anxiety, additional, Lueken, Ulrike, additional, Veltman, Dick J., additional, Winkler, Anderson M., additional, Jahanshad, Neda, additional, Pine, Daniel S., additional, Thompson, Paul M., additional, Stein, Dan J., additional, and van der Wee, Nic J.A., additional

Published
2023
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19. Concurrent validity and reliability of suicide risk assessment instruments: A meta-analysis of 20 instruments across 27 international cohorts.

Author

Campos, Adrian I., primary, Van Velzen, Laura S., additional, Veltman, Dick J., additional, Pozzi, Elena, additional, Ambrogi, Sonia, additional, Ballard, Elizabeth D., additional, Banaj, Nerisa, additional, Başgöze, Zeynep, additional, Bellow, Sophie, additional, Benedetti, Francesco, additional, Bollettini, Irene, additional, Brosch, Katharina, additional, Canales-Rodríguez, Erick J., additional, Clarke-Rubright, Emily K., additional, Colic, Lejla, additional, Connolly, Colm G., additional, Courtet, Philippe, additional, Cullen, Kathryn R., additional, Dannlowski, Udo, additional, Dauvermann, Maria R., additional, Davey, Christopher G., additional, Deverdun, Jeremy, additional, Dohm, Katharina, additional, Erwin-Grabner, Tracy, additional, Goya-Maldonado, Roberto, additional, Fani, Negar, additional, Fortea, Lydia, additional, Fuentes-Claramonte, Paola, additional, Gonul, Ali Saffet, additional, Gotlib, Ian H., additional, Grotegerd, Dominik, additional, Harris, Mathew A., additional, Harrison, Ben J., additional, Haswell, Courtney C., additional, Hawkins, Emma L., additional, Hill, Dawson, additional, Hirano, Yoshiyuki, additional, Ho, Tiffany C., additional, Jollant, Fabrice, additional, Jovanovic, Tanja, additional, Kircher, Tilo, additional, Klimes-Dougan, Bonnie, additional, le Bars, Emmanuelle, additional, Lochner, Christine, additional, McIntosh, Andrew M., additional, Meinert, Susanne, additional, Mekawi, Yara, additional, Melloni, Elisa, additional, Mitchell, Philip, additional, Morey, Rajendra A., additional, Nakagawa, Akiko, additional, Nenadić, Igor, additional, Olié, Emilie, additional, Pereira, Fabricio, additional, Phillips, Rachel D., additional, Piras, Fabrizio, additional, Poletti, Sara, additional, Pomarol-Clotet, Edith, additional, Radua, Joaquim, additional, Ressler, Kerry J., additional, Roberts, Gloria, additional, Rodriguez-Cano, Elena, additional, Sacchet, Matthew D., additional, Salvador, Raymond, additional, Sandu, Anca-Larisa, additional, Shimizu, Eiji, additional, Singh, Aditya, additional, Spalletta, Gianfranco, additional, Steele, J. Douglas, additional, Stein, Dan J., additional, Stein, Frederike, additional, Stevens, Jennifer S., additional, Teresi, Giana I., additional, Uyar-Demir, Aslihan, additional, van der Wee, Nic J., additional, van der Werff, Steven J., additional, van Rooij, Sanne J. H., additional, Vecchio, Daniela, additional, Verdolini, Norma, additional, Vieta, Eduard, additional, Waiter, Gordon D., additional, Whalley, Heather, additional, Whittle, Sarah L., additional, Yang, Tony T., additional, Zarate, Carlos A., additional, Thompson, Paul M., additional, Jahanshad, Neda, additional, van Harmelen, Anne-Laura, additional, Blumberg, Hilary P., additional, Schmaal, Lianne, additional, and Rentería, Miguel E., additional

Published
2023
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20. Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group

Author

UCL - SSH/IPSY - Psychological Sciences Research Institute, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Amod, Alyssa R., Laansma, Max A., Van Velzen, Laura S., Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Blair, James R., Blair, Karina S., Hirsch, Joy, Pantazatos, Spiro P., Schneier, Franklin R., Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R. K., Thomopoulos, Sophia I., Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C., Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P. Michiel, Heeren, Alexandre, Cremers, Henk R., Hofmann, David, Straube, Thomas, Doruyter, Alexander G. G., Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Filippi, Courtney A., Gold, Andrea L., Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J., Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J., Sindermann, Lisa, Ball, Tali M., Fonzo, Gregory A., Paulus, Martin P., Simmons, Alan, Stein, Murray B., Klumpp, Heide, Phan, K. Luan, Furmark, Tomas, Månsson, Kristoffer N. T., Manzouri, Amirhossein, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Feola, Brandee, Harper, Jennifer C., Sylvester, Chad M., Lueken, Ulrike, Veltman, Dick J., Winkler, Anderson M., Jahanshad, Neda, Pine, Daniel S., Thompson, Paul M., Stein, Dan J., Van der Wee, Nic J. A., UCL - SSH/IPSY - Psychological Sciences Research Institute, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Amod, Alyssa R., Laansma, Max A., Van Velzen, Laura S., Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Blair, James R., Blair, Karina S., Hirsch, Joy, Pantazatos, Spiro P., Schneier, Franklin R., Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R. K., Thomopoulos, Sophia I., Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C., Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P. Michiel, Heeren, Alexandre, Cremers, Henk R., Hofmann, David, Straube, Thomas, Doruyter, Alexander G. G., Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Filippi, Courtney A., Gold, Andrea L., Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J., Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J., Sindermann, Lisa, Ball, Tali M., Fonzo, Gregory A., Paulus, Martin P., Simmons, Alan, Stein, Murray B., Klumpp, Heide, Phan, K. Luan, Furmark, Tomas, Månsson, Kristoffer N. T., Manzouri, Amirhossein, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Feola, Brandee, Harper, Jennifer C., Sylvester, Chad M., Lueken, Ulrike, Veltman, Dick J., Winkler, Anderson M., Jahanshad, Neda, Pine, Daniel S., Thompson, Paul M., Stein, Dan J., and Van der Wee, Nic J. A.

Abstract

There is limited convergence in neuroimaging investigations into volumes of subcortical brain regions in social anxiety disorder (SAD). The inconsistent findings may arise from variations in methodological approaches across studies, including sample selection based on age and clinical characteristics. The ENIGMA-Anxiety Working Group initiated a global mega-analysis to determine whether differences in subcortical volumes can be detected in adults and adolescents with SAD relative to healthy controls. Volumetric data from 37 international samples with 1115 SAD patients and 2775 controls were obtained from ENIGMA-standardized protocols for image segmentation and quality assurance. Linear mixed-effects analyses were adjusted for comparisons across seven subcortical regions in each hemisphere using family-wise error (FWE)-correction. Mixed-effects d effect sizes were calculated. In the full sample, SAD patients showed smaller bilateral putamen volume than controls (left: d = −0.077, pFWE = 0.037; right: d = −0.104, pFWE = 0.001), and a significant interaction between SAD and age was found for the left putamen (r = −0.034, pFWE = 0.045). Smaller bilateral putamen volumes (left: d = −0.141, pFWE < 0.001; right: d = −0.158, pFWE < 0.001) and larger bilateral pallidum volumes (left: d = 0.129, pFWE = 0.006; right: d = 0.099, pFWE = 0.046) were detected in adult SAD patients relative to controls, but no volumetric differences were apparent in adolescent SAD patients relative to controls. Comorbid anxiety disorders and age of SAD onset were additional determinants of SAD-related volumetric differences in subcortical regions. To conclude, subtle volumetric alterations in subcortical regions in SAD were detected. Heterogeneity in age and clinical characteristics may partly explain inconsistencies in previous findings. The association between alterations in subcortical volumes and SAD illness progression deserves further investigation, especially from adolescence into adulthood.

Published
2023

21. Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group

Author

Groenewold, Nynke A, Bas-Hoogendam, Janna Marie, Amod, Alyssa R, Laansma, Max A, Van Velzen, Laura S, Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P, Pan, Pedro M, Salum, Giovanni A, Blair, James R, Blair, Karina S, Hirsch, Joy, Pantazatos, Spiro P, Schneier, Franklin R, Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R K, Thomopoulos, Sophia I, Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C, Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P Michiel, Heeren, Alexandre, Cremers, Henk R, Hofmann, David, Straube, Thomas, Doruyter, Alexander G G, Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E, Kaczkurkin, Antonia N, Larsen, Bart, Satterthwaite, Theodore D, Filippi, Courtney A, Gold, Andrea L, Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J, Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J, Sindermann, Lisa, Ball, Tali M, Fonzo, Gregory A, Paulus, Martin P, Simmons, Alan, Stein, Murray B, Klumpp, Heide, Phan, K Luan, Furmark, Tomas, Månsson, Kristoffer N T, Manzouri, Amirhossein, Avery, Suzanne N, Blackford, Jennifer Urbano, Clauss, Jacqueline A, Feola, Brandee, Harper, Jennifer C, Sylvester, Chad M, Lueken, Ulrike, Veltman, Dick J, Winkler, Anderson M, Jahanshad, Neda, Pine, Daniel S, Thompson, Paul M, Stein, Dan J, Van der Wee, Nic J A, Groenewold, Nynke A, Bas-Hoogendam, Janna Marie, Amod, Alyssa R, Laansma, Max A, Van Velzen, Laura S, Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P, Pan, Pedro M, Salum, Giovanni A, Blair, James R, Blair, Karina S, Hirsch, Joy, Pantazatos, Spiro P, Schneier, Franklin R, Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R K, Thomopoulos, Sophia I, Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C, Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P Michiel, Heeren, Alexandre, Cremers, Henk R, Hofmann, David, Straube, Thomas, Doruyter, Alexander G G, Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E, Kaczkurkin, Antonia N, Larsen, Bart, Satterthwaite, Theodore D, Filippi, Courtney A, Gold, Andrea L, Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J, Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J, Sindermann, Lisa, Ball, Tali M, Fonzo, Gregory A, Paulus, Martin P, Simmons, Alan, Stein, Murray B, Klumpp, Heide, Phan, K Luan, Furmark, Tomas, Månsson, Kristoffer N T, Manzouri, Amirhossein, Avery, Suzanne N, Blackford, Jennifer Urbano, Clauss, Jacqueline A, Feola, Brandee, Harper, Jennifer C, Sylvester, Chad M, Lueken, Ulrike, Veltman, Dick J, Winkler, Anderson M, Jahanshad, Neda, Pine, Daniel S, Thompson, Paul M, Stein, Dan J, and Van der Wee, Nic J A

Abstract

There is limited convergence in neuroimaging investigations into volumes of subcortical brain regions in social anxiety disorder (SAD). The inconsistent findings may arise from variations in methodological approaches across studies, including sample selection based on age and clinical characteristics. The ENIGMA-Anxiety Working Group initiated a global mega-analysis to determine whether differences in subcortical volumes can be detected in adults and adolescents with SAD relative to healthy controls. Volumetric data from 37 international samples with 1115 SAD patients and 2775 controls were obtained from ENIGMA-standardized protocols for image segmentation and quality assurance. Linear mixed-effects analyses were adjusted for comparisons across seven subcortical regions in each hemisphere using family-wise error (FWE)-correction. Mixed-effects d effect sizes were calculated. In the full sample, SAD patients showed smaller bilateral putamen volume than controls (left: d = -0.077, p FWE = 0.037; right: d = -0.104, p FWE = 0.001), and a significant interaction between SAD and age was found for the left putamen (r = -0.034, p FWE = 0.045). Smaller bilateral putamen volumes (left: d = -0.141, p FWE < 0.001; right: d = -0.158, p FWE < 0.001) and larger bilateral pallidum volumes (left: d = 0.129, p FWE = 0.006; right: d = 0.099, p FWE = 0.046) were detected in adult SAD patients relative to controls, but no volumetric differences were apparent in adolescent SAD patients relative to controls. Comorbid anxiety disorders and age of SAD onset were additional determinants of SAD-related volumetric differences in subcortical regions. To conclude, subtle volumetric alterations in subcortical regions in SAD were detected. Heterogeneity in age and clinical characteristics may partly explain inconsistencies in previous findings. The association between alterations in subcortical volumes and SAD illness progression deserves further investigation, especially from adol

Published
2023

22. Brain grey and white matter structural associations with future suicidal ideation and behaviors in adolescent and young adult females with mood disorders

Author

Colic, Lejla, Villa, Luca M, Dauvermann, Maria R, Van Velzen, Laura S, Sankar, Anjali, Goldman, Danielle A, Panchal, Priyanka, Kim, Jihoon A, Quatrano, Susan, Spencer, Linda, Constable, R Todd, Suckling, John, Goodyer, Ian M, Schmaal, Lianne, Van Harmelen, Anne-Laura, Blumberg, Hilary P, Colic, Lejla [0000-0002-8809-4034], van Velzen, Laura S [0000-0002-6003-5227], and Apollo - University of Cambridge Repository

Subjects
suicidal behaviour, gender, magnetic resonance imaging, adolescence, mood disorder
Abstract

Funder: American Foundation for Suicide Prevention; Id: http://dx.doi.org/10.13039/100001455, Funder: AIM Youth Mental Health Foundation, Funder: For the Love of Travis Foundation, Funder: International Bipolar Foundation, Funder: Interdisciplinary Center of Clinical Research of the Medical Faculty Jena, Funder: Leiden University Social Safety and Resilience program, Funder: Behavioural and Clinical Neuroscience Institute, University of Cambridge, Funder: Klingenstein Third Generation Foundation; Id: http://dx.doi.org/10.13039/100006211, Funder: University of Melbourne Dame Kate Campbell fellowship, Funder: Suicide Prevention Australia; Id: http://dx.doi.org/10.13039/501100019998, BACKGROUND: To reduce suicide in females with mood disorders, it is critical to understand brain substrates underlying their vulnerability to future suicidal ideation and behaviors (SIBs) in adolescence and young adulthood. In an international collaboration, grey and white matter structure was investigated in adolescent and young adult females with future suicidal behaviors (fSB) and ideation (fSI), and without SIBs (fnonSIB). METHODS: Structural (n = 91) and diffusion-weighted (n = 88) magnetic resonance imaging scans at baseline and SIB measures at follow-up on average two years later (standard deviation, SD = 1 year) were assessed in 92 females [age(SD) = 16.1(2.6) years] with bipolar disorder (BD, 28.3%) or major depressive disorder (MDD, 71.7%). One-way analyses of covariance comparing baseline regional grey matter cortical surface area, thickness, subcortical grey volumes, or white matter tensor-based fractional anisotropy across fSB (n = 40, 43.5%), fSI (n = 33, 35.9%) and fnonSIB (n = 19, 20.6%) groups were followed by pairwise comparisons in significant regions (p < 0.05). RESULTS: Compared to fnonSIBs, fSIs and fSBs showed significant decreases in cortical thickness of right inferior frontal gyrus pars orbitalis and middle temporal gyrus, fSIs of left inferior frontal gyrus, pars orbitalis. FSIs and fSBs showed lower fractional anisotropy in left uncinate fasciculus and corona radiata, and fSBs in right uncinate and superior fronto-occipital fasciculi. CONCLUSIONS: The study provides preliminary evidence of grey and white matter alterations in brain regions subserving emotional and behavioral regulation and perceptual processing in adolescent and young adult females with mood disorders with, versus without, future SIBs. Findings suggest potential targets to prevent SIBs in female adolescents and young adults.

Published
2022
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23. Functional MRI Correlates of Emotion Regulation in Major Depressive Disorder Related to Depressive Disease Load Measured Over Nine Years

Author

van Kleef, Rozemarijn Surya, primary, Müller, Amke, additional, van Velzen, Laura S., additional, Bas-Hoogendam, Janna Marie, additional, van der Wee, Nic J.A., additional, Schmaal, Lianne, additional, Veltman, Dick J., additional, Rive, Maria M., additional, Ruhé, Henricus G., additional, Marsman, Jan-Bernard C., additional, and van Tol, Marie-José, additional

Published
2023
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24. Brain grey and white matter structural associations with future suicidal ideation and behaviors in adolescent and young adult females with mood disorders

Author

Colic, Lejla, primary, Villa, Luca M., additional, Dauvermann, Maria R., additional, van Velzen, Laura S., additional, Sankar, Anjali, additional, Goldman, Danielle A., additional, Panchal, Priyanka, additional, Kim, Jihoon A., additional, Quatrano, Susan, additional, Spencer, Linda, additional, Constable, R. Todd, additional, Suckling, John, additional, Goodyer, Ian M., additional, Schmaal, Lianne, additional, van Harmelen, Anne‐Laura, additional, and Blumberg, Hilary P., additional

Published
2022
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26. FreeSurfer-based segmentation of hippocampal subfields: A review of methods and applications, with a novel quality control procedure for ENIGMA studies and other collaborative efforts.

Author

Sämann, Philipp G, Sämann, Philipp G, Iglesias, Juan Eugenio, Gutman, Boris, Grotegerd, Dominik, Leenings, Ramona, Flint, Claas, Dannlowski, Udo, Clarke-Rubright, Emily K, Morey, Rajendra A, van Erp, Theo GM, Whelan, Christopher D, Han, Laura KM, van Velzen, Laura S, Cao, Bo, Augustinack, Jean C, Thompson, Paul M, Jahanshad, Neda, Schmaal, Lianne, Sämann, Philipp G, Sämann, Philipp G, Iglesias, Juan Eugenio, Gutman, Boris, Grotegerd, Dominik, Leenings, Ramona, Flint, Claas, Dannlowski, Udo, Clarke-Rubright, Emily K, Morey, Rajendra A, van Erp, Theo GM, Whelan, Christopher D, Han, Laura KM, van Velzen, Laura S, Cao, Bo, Augustinack, Jean C, Thompson, Paul M, Jahanshad, Neda, and Schmaal, Lianne

Abstract

Structural hippocampal abnormalities are common in many neurological and psychiatric disorders, and variation in hippocampal measures is related to cognitive performance and other complex phenotypes such as stress sensitivity. Hippocampal subregions are increasingly studied, as automated algorithms have become available for mapping and volume quantification. In the context of the Enhancing Neuro Imaging Genetics through Meta Analysis Consortium, several Disease Working Groups are using the FreeSurfer software to analyze hippocampal subregion (subfield) volumes in patients with neurological and psychiatric conditions along with data from matched controls. In this overview, we explain the algorithm's principles, summarize measurement reliability studies, and demonstrate two additional aspects (subfield autocorrelation and volume/reliability correlation) with illustrative data. We then explain the rationale for a standardized hippocampal subfield segmentation quality control (QC) procedure for improved pipeline harmonization. To guide researchers to make optimal use of the algorithm, we discuss how global size and age effects can be modeled, how QC steps can be incorporated and how subfields may be aggregated into composite volumes. This discussion is based on a synopsis of 162 published neuroimaging studies (01/2013-12/2019) that applied the FreeSurfer hippocampal subfield segmentation in a broad range of domains including cognition and healthy aging, brain development and neurodegeneration, affective disorders, psychosis, stress regulation, neurotoxicity, epilepsy, inflammatory disease, childhood adversity and posttraumatic stress disorder, and candidate and whole genome (epi-)genetics. Finally, we highlight points where FreeSurfer-based hippocampal subfield studies may be optimized.

Published
2022

27. Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium

Author

Universidad de Sevilla. Departamento de Psiquiatría, American Foundation for Suicide Prevention (AFSP), Australian National Health and Medical Research Council (NHMRC), Biotechnology Research Center, Brain and Behavior Research Foundation, CJ Martin Fellowship (NHMRC), Deborah E. Powell Center for Women's Health Seed Grant, University of Minnesota, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) /Fondo Social Europeo "Invertir en tu futuro", Famous Doctors Project of Yunnan Province Plan, For the Love of Travis Foundation, Fundacion Instituto de Investigacion Marques de Valdecilla, Deutsche Forschungsgemeinschaft / German Research Foundation (DFG), Good Talk, Instituto de Salud Carlos III, Interdisziplinares Zentrum fur Klinische Forschung, UKJ, International Bipolar Foundation, Ministerio italiano de Salud, J. Jacobson Fund., Janette Mary O'Neil Research Fellowship, Keith Pettigrew Family Bequest, Klingenstein Third Generation Foundation, Lansdowne Foundation, Medical Faculty Munster, Innovative Medizinische Forschung, Medical Leader Foundation of Yunnan Province, Minnesota Medical Foundation, MQ Brighter Futures, MQ Brighter Futures Award, National Alliance for Research on Schizophrenia and Depression, National Center for Advancing Translational Sciences (CTSI), National Institutes of Health, National Center for Complementary and Integrative Health (NCCIH), National Institute of Mental Health (NIMH), NHMRC Career Development Fellowships, NIAAA, Program "Investissements d'avenir", Ray and Dagmar Dolby Family Fund., Social Safety and Resilience program of Leiden University, Stanford Center for Cognitive and Neurobiological Imaging, Stanford Maternal Child Health Research Institute, U.S. National Institute of Mental Health, UCSF Research Evaluation and Allocation Committee (REAC), University of Minnesota, Women's Health Research at Yale, van Velzen, Laura S., Dauvermann, Maria R., Colic, Lejla, Villa, Luca M., Savage, Hannah S., Toenders, Yara J., Crespo Facorro, Benedicto, Schmaal, Lianne, Universidad de Sevilla. Departamento de Psiquiatría, American Foundation for Suicide Prevention (AFSP), Australian National Health and Medical Research Council (NHMRC), Biotechnology Research Center, Brain and Behavior Research Foundation, CJ Martin Fellowship (NHMRC), Deborah E. Powell Center for Women's Health Seed Grant, University of Minnesota, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) /Fondo Social Europeo "Invertir en tu futuro", Famous Doctors Project of Yunnan Province Plan, For the Love of Travis Foundation, Fundacion Instituto de Investigacion Marques de Valdecilla, Deutsche Forschungsgemeinschaft / German Research Foundation (DFG), Good Talk, Instituto de Salud Carlos III, Interdisziplinares Zentrum fur Klinische Forschung, UKJ, International Bipolar Foundation, Ministerio italiano de Salud, J. Jacobson Fund., Janette Mary O'Neil Research Fellowship, Keith Pettigrew Family Bequest, Klingenstein Third Generation Foundation, Lansdowne Foundation, Medical Faculty Munster, Innovative Medizinische Forschung, Medical Leader Foundation of Yunnan Province, Minnesota Medical Foundation, MQ Brighter Futures, MQ Brighter Futures Award, National Alliance for Research on Schizophrenia and Depression, National Center for Advancing Translational Sciences (CTSI), National Institutes of Health, National Center for Complementary and Integrative Health (NCCIH), National Institute of Mental Health (NIMH), NHMRC Career Development Fellowships, NIAAA, Program "Investissements d'avenir", Ray and Dagmar Dolby Family Fund., Social Safety and Resilience program of Leiden University, Stanford Center for Cognitive and Neurobiological Imaging, Stanford Maternal Child Health Research Institute, U.S. National Institute of Mental Health, UCSF Research Evaluation and Allocation Committee (REAC), University of Minnesota, Women's Health Research at Yale, van Velzen, Laura S., Dauvermann, Maria R., Colic, Lejla, Villa, Luca M., Savage, Hannah S., Toenders, Yara J., Crespo Facorro, Benedicto, and Schmaal, Lianne

Abstract

Identifying brain alterations associated with suicidal thoughts and behaviors (STBs) in young people is critical to understanding their development and improving early intervention and prevention. The ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium analyzed neuroimaging data harmonized across sites to examine brain morphology associated with STBs in youth. We performed analyses in three separate stages, in samples ranging from most to least homogeneous in terms of suicide assessment instrument and mental disorder. First, in a sample of 577 young people with mood disorders, in which STBs were assessed with the Columbia Suicide Severity Rating Scale (C-SSRS). Second, in a sample of young people with mood disorders, in which STB were assessed using different instruments, MRI metrics were compared among healthy controls without STBs (HC; N = 519), clinical controls with a mood disorder but without STBs (CC; N = 246) and young people with current suicidal ideation (N = 223). In separate analyses, MRI metrics were compared among HCs (N = 253), CCs (N = 217), and suicide attempters (N = 64). Third, in a larger transdiagnostic sample with various assessment instruments (HC = 606; CC = 419; Ideation = 289; HC = 253; CC = 432; Attempt=91). In the homogeneous C-SSRS sample, surface area of the frontal pole was lower in young people with mood disorders and a history of actual suicide attempts (N = 163) than those without a lifetime suicide attempt (N = 323; FDR-p = 0.035, Cohen’s d = 0.34). No associations with suicidal ideation were found. When examining more heterogeneous samples, we did not observe significant associations. Lower frontal pole surface area may represent a vulnerability for a (non-interrupted and non-aborted) suicide attempt; however, more research is needed to understand the nature of its relationship to suicide risk.

Published
2022

28. Risk factors for suicide attempt during outpatient care in adolescents with severe and complex depression

Author

van Velzen, Laura S, Toenders, Yara J, Kottaram, Akhil, Youzchalveen, Belinsha, Pilkington, Vita, Cotton, Sue M, Brooker, Abi, McKechnie, Ben, Rice, Simon, Schmaal, Lianne, van Velzen, Laura S, Toenders, Yara J, Kottaram, Akhil, Youzchalveen, Belinsha, Pilkington, Vita, Cotton, Sue M, Brooker, Abi, McKechnie, Ben, Rice, Simon, and Schmaal, Lianne

Abstract

Background: Young people receiving tertiary mental health care are at elevated risk for suicidal behavior, and understanding which individuals are at increased risk during care is important for treatment and suicide prevention. Aim: We aimed to retrospectively identify risk factors for attempted suicide during outpatient care and predict which young people did or did not attempt during care. Method: Penalized logistic regression analysis was performed in a small high-risk sample of 84 young people receiving care at Orygen's Youth Mood Clinic (age: 14-25 years, 51% female) to predict suicide attempt during care (N = 16). Results: Prediction of suicide attempt during care was only moderately accurate (Area Under the Receiver Operating Curve range 0.71; sensitivity 0.57) using a combination of sociodemographic, psychosocial, and clinical variables. The features that best discriminated both groups included suicidal ideation during care, history of suicide attempt prior to care, changes in appetite reported on the PHQ-9, history of parental separation, and parental mental illness. Limitation: Replication of findings in an independent validation sample is needed. Conclusion: While prediction of suicide attempt during care was only moderately successful, we were able to identify individual risk factors for suicidal behavior during care in a high-risk sample.

Published
2022

29. The relation between cannabis use, dependence severity and white matter microstructure:A diffusion tensor imaging study

Author

Cousijn, Janna, Toenders, Yara, van Velzen, Laura S, Kaag, Anne Marije, Cousijn, Janna, Toenders, Yara, van Velzen, Laura S, and Kaag, Anne Marije

Abstract

Despite the significant societal and personal burden of cannabis use, the impact of long-term use and Cannabis Use Disorder (CUD) on white matter microstructure is still unclear. Previous studies show inconsistent findings, in part due to heterogeneity in methodology, variable severity of cannabis use, and potential confounding effects of other mental health issues and substance use. The goal of this diffusion tensor imaging (DTI) study was to compare whole-brain white matter microstructure between 39 near daily cannabis users and 28 controls closely matched on age, sex, alcohol use, cigarette use and mental health. Within the group of cannabis users, associations between white matter microstructure and recent cannabis use, dependence severity, and age of onset and duration of weekly use were investigated. White matter microstructure did not differ between cannabis users and controls and did not covary with recent cannabis use, dependence severity, or duration of use. Earlier onset of weekly cannabis use was related to lower fractional anisotropy (FA) in various sections of the right inferior longitudinal fasciculus and uncinate fasciculus. These findings suggest that long-term near-daily cannabis use does not necessarily affect white matter microstructure, but vulnerability may be higher during adolescence. These findings underscore the importance of sample composition and warrant further studies that investigate the moderating role of age of onset in the impact of cannabis on the brain.

Published
2022

31. Genomics-driven screening for causal determinants of suicide attempt.

Author

Campos, Adrian I, Garcia-Marin, Luis M, Christensen, Helen, Batterham, Philip J, van Velzen, Laura S, Schmaal, Lianne, Rabinowitz, Jill A, Jahanshad, Neda, Martin, Nicholas G, Cuellar-Partida, Gabriel, Ruderfer, Douglas, Mullins, Niamh, and Rentería, Miguel E

Subjects
SUICIDE risk factors, SUICIDE, GENETICS, SUBSTANCE abuse, GENETIC testing, MENTAL health, RISK assessment, FIBROMYALGIA, GENOMICS, MENTAL depression, ANXIETY disorders, ESOPHAGUS diseases, ANXIETY
Abstract

Objective: Each year, around one million people die by suicide. Despite its recognition as a public health concern, large-scale research on causal determinants of suicide attempt risk is scarce. Here, we leverage results from a recent genome-wide association study (GWAS) of suicide attempt to perform a data-driven screening of traits causally associated with suicide attempt. Methods: We performed a hypothesis-generating phenome-wide screening of causal relationships between suicide attempt risk and 1520 traits, which have been systematically aggregated on the Complex-Traits Genomics Virtual Lab platform. We employed the latent causal variable (LCV) method, which uses results from GWAS to assess whether a causal relationship can explain a genetic correlation between two traits. If a trait causally influences another one, the genetic variants that increase risk for the causal trait will also increase the risk for the outcome inducing a genetic correlation. Nonetheless, a genetic correlation can also be observed when traits share common pathways. The LCV method can assess whether the pattern of genetic effects for two genetically correlated traits support a causal association rather than a shared aetiology. Results: Our approach identified 62 traits that increased risk for suicide attempt. Risk factors identified can be broadly classified into (1) physical health disorders, including oesophagitis, fibromyalgia, hernia and cancer; (2) mental health-related traits, such as depression, substance use disorders and anxiety; and (3) lifestyle traits including being involved in combat or exposure to a war zone, and specific job categories such as being a truck driver or machine operator. Conclusions: Suicide attempt risk is likely explained by a combination of behavioural phenotypes and risk for both physical and psychiatric disorders. Our results also suggest that substance use behaviours and pain-related conditions are associated with an increased suicide attempt risk, elucidating important causal mechanisms that underpin this significant public health problem. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Genomics Driven Screening for Causal Determinants of Suicide Attempt

Author

Campos, Adrián I., primary, García-Marín, Luis M., additional, Christensen, Helen, additional, Batterham, Philip J., additional, van Velzen, Laura S., additional, Schmaal, Lianne, additional, Rabinowitz, Jill A., additional, Jahanshad, Neda, additional, Martin, Nicholas G., additional, Cuéllar-Partida, Gabriel, additional, Ruderfer, Douglas M., additional, Mullins, Niamh, additional, and Renteria, Miguel E., additional

Published
2022
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33. Inhibitor development and mortality in non-severe hemophilia A

Author

Eckhardt, C. L., Loomans, J. I., van Velzen, A. S., Peters, M., Mauser-Bunschoten, E. P., Schwaab, R., Mazzucconi, M. G., Tagliaferri, A., Siegmund, B., Reitter-Pfoertner, S. E., van der Bom, J. G., Fijnvandraat, K., Kamphuisen, P. W., Peerlinck, K., Oldenburg, J., Santagostino, E., Astermark, J., Eckhardt, C. L, van Velzen, A. S, Streefkerk, N., Loomans, J. L., van Eijkelenburg, A., Jansen, A. J., Kruijt, C. C., van Tienoven, B., van Baar, A. C. G., Corten, I. W., Meijer, K., Nijziel, M. R., Dors, N., Hamulyak, K., Beckers, E., Brons, P. P., Laros-van Gorkom, B. A. P., van Heerde, W. L., Leebeek, F., Kruip, M., Cnossen, M. H., Mauser-Bunschoten, E., Fischer, K., Smiers, F. J., Hermans, C., Klamroth, R., Escuriola-Ettingshausen, C., Königs, C., Petrini, P., Holmström, M., Mäkipernaa, A., Male, C., Pabinger, I., Keenan, R. D., Liesner, R., Khair, K., Yee, T. T., Hart, D. P., Rangarajan, S., Mitchell, M., Thompson, G., Haya, S., Moret, A., Cid, A. R., Jimenez-Yuste, V., Mancuso, M. E., Mazzuconni, M. G., Santoro, C., Morfini, M., Castaman, G., Schinco, P., Rivolta, G. F., Platokouki, H., and McRae, S.

Published
2015
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34. sj-docx-1-anp-10.1177_00048674221091499 – Supplemental material for Genomics-driven screening for causal determinants of suicide attempt

Author

Campos, Adrian I, Garcia-Marin, Luis M, Christensen, Helen, Batterham, Philip J, van Velzen, Laura S, Schmaal, Lianne, Rabinowitz, Jill A, Jahanshad, Neda, Martin, Nicholas G, Cuellar-Partida, Gabriel, Ruderfer, Douglas, Mullins, Niamh, and Rentería, Miguel E

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), Neuroscience
Abstract

Supplemental material, sj-docx-1-anp-10.1177_00048674221091499 for Genomics-driven screening for causal determinants of suicide attempt by Adrian I Campos, Luis M Garcia-Marin, Helen Christensen, Philip J Batterham, Laura S van Velzen, Lianne Schmaal, Jill A Rabinowitz, Neda Jahanshad, Nicholas G Martin, Gabriel Cuellar-Partida, Douglas Ruderfer, Niamh Mullins and Miguel E Rentería in Australian & New Zealand Journal of Psychiatry

Published
2022
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35. sj-docx-3-anp-10.1177_00048674221091499 – Supplemental material for Genomics-driven screening for causal determinants of suicide attempt

Author

Campos, Adrian I, Garcia-Marin, Luis M, Christensen, Helen, Batterham, Philip J, van Velzen, Laura S, Schmaal, Lianne, Rabinowitz, Jill A, Jahanshad, Neda, Martin, Nicholas G, Cuellar-Partida, Gabriel, Ruderfer, Douglas, Mullins, Niamh, and Rentería, Miguel E

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), Neuroscience
Abstract

Supplemental material, sj-docx-3-anp-10.1177_00048674221091499 for Genomics-driven screening for causal determinants of suicide attempt by Adrian I Campos, Luis M Garcia-Marin, Helen Christensen, Philip J Batterham, Laura S van Velzen, Lianne Schmaal, Jill A Rabinowitz, Neda Jahanshad, Nicholas G Martin, Gabriel Cuellar-Partida, Douglas Ruderfer, Niamh Mullins and Miguel E Rentería in Australian & New Zealand Journal of Psychiatry

Published
2022
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36. Classification of suicidal thoughts and behaviour in children: results from penalised logistic regression analyses in the Adolescent Brain Cognitive Development study

Author

van Velzen, Laura S., primary, Toenders, Yara J., additional, Avila-Parcet, Aina, additional, Dinga, Richard, additional, Rabinowitz, Jill A., additional, Campos, Adrián I., additional, Jahanshad, Neda, additional, Rentería, Miguel E., additional, and Schmaal, Lianne, additional

Published
2022
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37. Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group

Author

Schmaal, L, Veltman, D J, van Erp, T GM, Sämann, P G, Frodl, T, Jahanshad, N, Loehrer, E, Tiemeier, H, Hofman, A, Niessen, W J, Vernooij, M W, Ikram, M A, Wittfeld, K, Grabe, H J, Block, A, Hegenscheid, K, Völzke, H, Hoehn, D, Czisch, M, Lagopoulos, J, Hatton, S N, Hickie, I B, Goya-Maldonado, R, Krämer, B, Gruber, O, Couvy-Duchesne, B, Rentería, M E, Strike, L T, Mills, N T, de Zubicaray, G I, McMahon, K L, Medland, S E, Martin, N G, Gillespie, N A, Wright, M J, Hall, G B, MacQueen, G M, Frey, E M, Carballedo, A, van Velzen, L S, van Tol, M J, van der Wee, N J, Veer, I M, Walter, H, Schnell, K, Schramm, E, Normann, C, Schoepf, D, Konrad, C, Zurowski, B, Nickson, T, McIntosh, A M, Papmeyer, M, Whalley, H C, Sussmann, J E, Godlewska, B R, Cowen, P J, Fischer, F H, Rose, M, Penninx, B WJH, Thompson, P M, and Hibar, D P

Published
2016
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38. Response to Dr Fried & Dr Kievit, and Dr Malhi et al.

Author

Schmaal, L, Veltman, D J, van Erp, T GM, Sämann, P G, Frodl, T, Jahanshad, N, Loehrer, E, Vernooij, M W, Niessen, W J, Ikram, M A, Wittfeld, K, Grabe, H J, Block, A, Hegenscheid, K, Hoehn, D, Czisch, M, Lagopoulos, J, Hatton, S N, Hickie, I B, Goya-Maldonado, R, Krämer, B, Gruber, O, Couvy-Duchesne, B, Rentería, M E, Strike, L T, Wright, M J, de Zubicaray, G I, McMahon, K L, Medland, S E, Gillespie, N A, Hall, G B, van Velzen, L S, van Tol, M-J, van der Wee, N J, Veer, I M, Walter, H, Schramm, E, Normann, C, Schoepf, D, Konrad, C, Zurowski, B, McIntosh, A M, Whalley, H C, Sussmann, J E, Godlewska, B R, Fischer, F H, Penninx, B WJH, Thompson, P M, and Hibar, D P

Published
2016
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40. Heritability and reliability of automatically segmented human hippocampal formation subregions

Author

Whelan, Christopher D., Hibar, Derrek P., van Velzen, Laura S., Zannas, Anthony S., Carrillo-Roa, Tania, McMahon, Katie, Prasad, Gautam, Kelly, Sinéad, Faskowitz, Joshua, deZubiracay, Greig, Iglesias, Juan E., van Erp, Theo G.M., Frodl, Thomas, Martin, Nicholas G., Wright, Margaret J., Jahanshad, Neda, Schmaal, Lianne, Sämann, Philipp G., and Thompson, Paul M.

Published
2016
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41. Structural brain alterations associated with suicidal thoughts and behaviors in young people: results across 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium

Author

van Velzen, Laura S., primary, Dauvermann, Maria R., additional, Colic, Lejla, additional, Villa, Luca M., additional, Savage, Hannah S., additional, Toenders, Yara J., additional, Zhu, Alyssa H., additional, Bright, Joanna K., additional, Campos, Adrián I., additional, Salminen, Lauren, additional, Ambrogi, Sonia, additional, Ayesa-Arriola, Rosa, additional, Banaj, Nerisa, additional, Başgöze, Zeynep, additional, Bauer, Jochen, additional, Blair, Karina, additional, Blair, Robert James, additional, Brosch, Katharina, additional, Cheng, Yuqi, additional, Colle, Romain, additional, Connolly, Colm G., additional, Corruble, Emmanuelle, additional, Couvy-Duchesne, Baptiste, additional, Crespo-Facorro, Benedicto, additional, Cullen, Kathryn R., additional, Dannlowski, Udo, additional, Davey, Christopher G., additional, Dohm, Katharina, additional, Fullerton, Janice M., additional, Gonul, Ali Saffet, additional, Gotlib, Ian H., additional, Grotegerd, Dominik, additional, Hahn, Tim, additional, Harrison, Ben J., additional, He, Mengxin, additional, Hickie, Ian B., additional, Ho, Tiffany C., additional, Iorfino, Frank, additional, Jansen, Andreas, additional, Jollant, Fabrice, additional, Kircher, Tilo, additional, Klimes-Dougan, Bonnie, additional, Klug, Melissa, additional, Leehr, Elisabeth J., additional, Lippard, Elizabeth T.C., additional, McLaughlin, Katie A., additional, Meinert, Susanne, additional, Miller, Adam Bryant, additional, Mitchell, Philip B., additional, Mwangi, Benson, additional, Nenadić, Igor, additional, Ojha, Amar, additional, Overs, Bronwyn J., additional, Pfarr, Julia-Katharina, additional, Piras, Fabrizio, additional, Ringwald, Kai G., additional, Roberts, Gloria, additional, Romer, Georg, additional, Sanches, Marsal, additional, Sheridan, Margaret A., additional, Soares, Jair C, additional, Spalletta, Gianfranco, additional, Stein, Frederike, additional, Teresi, Giana I., additional, Tordesillas-Gutiérrez, Diana, additional, Uyar-Demir, Aslihan, additional, van der Wee, Nic J.A., additional, van der Werff, Steven J., additional, Vermeiren, Robert R.J.M., additional, Winter, Alexandra, additional, Wu, Mon-Ju, additional, Yang, Tony T., additional, Thompson, Paul M., additional, Rentería, Miguel E., additional, Jahanshad, Neda, additional, Blumberg, Hilary P., additional, van Harmelen, Anne-Laura, additional, and Schmaal, Lianne, additional

Published
2021
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42. Concurrent validity and reliability of suicide risk assessment instruments: A meta analysis of 20 instruments across 27 international cohorts

Author

Campos, Adrian I., primary, Van Velzen, Laura S., additional, Veltman, Dick J., additional, Pozzi, Elena, additional, Ambrogi, Sonia, additional, Ballard, Elizabeth D., additional, Banaj, Nerisa, additional, Başgöze, Zeynep, additional, Bellow, Sophie, additional, Benedetti, Francesco, additional, Bollettini, Irene, additional, Brosch, Katharina, additional, Canales-Rodríguez, Erick J., additional, Clarke-Rubright, Emily K., additional, Colic, Lejla, additional, Connolly, Colm G., additional, Courtet, Philippe, additional, Cullen, Kathryn R., additional, Dannlowski, Udo, additional, Dauvermann, Maria R., additional, Davey, Christopher G., additional, Deverdun, Jeremy, additional, Dohm, Katharina, additional, Erwin-Grabner, Tracy, additional, Fani, Negar, additional, Fortea, Lydia, additional, Fuentes-Claramonte, Paola, additional, Gonul, Ali Saffet, additional, Gotlib, Ian H., additional, Grotegerd, Dominik, additional, Harris, Mathew A., additional, Harrison, Ben J., additional, Haswell, Courtney C., additional, Hawkins, Emma L., additional, Hill, Dawson, additional, Hirano, Yoshiyuki, additional, Ho, Tiffany C., additional, Jollant, Fabrice, additional, Jovanovic, Tanja, additional, Kircher, Tilo, additional, Klimes-Dougan, Bonnie, additional, le Bars, Emmanuelle, additional, Lochner, Christine, additional, McIntosh, Andrew M., additional, Meinert, Susanne, additional, Mekawi, Yara, additional, Melloni, Elisa, additional, Mitchell, Philip, additional, Morey, Rajendra A., additional, Nakagawa, Akiko, additional, Nenadić, Igor, additional, Olié, Emilie, additional, Pereira, Fabricio, additional, Phillips, Rachel D., additional, Piras, Fabrizio, additional, Poletti, Sara, additional, Pomarol-Clotet, Edith, additional, Radua, Joaquim, additional, Ressler, Kerry J., additional, Roberts, Gloria, additional, Rodriguez-Cano, Elena, additional, Sacchet, Matthew D., additional, Salvador, Raymond, additional, Sandu, Anca-Larisa, additional, Shimizu, Eiji, additional, Singh, Aditya, additional, Spalletta, Gianfranco, additional, Steele, J. Douglas, additional, Stein, Dan J., additional, Stein, Frederike, additional, Stevens, Jennifer S., additional, Teresi, Giana I., additional, Uyar-Demir, Aslihan, additional, van der Wee, Nic J., additional, van der Werff, Steven J., additional, van Rooij, Sanne J.H., additional, Vecchio, Daniela, additional, Verdolini, Norma, additional, Vieta, Eduard, additional, Waiter, Gordon D., additional, Whalley, Heather, additional, Whittle, Sarah L., additional, Yang, Tony T., additional, Zarate, Carlos A., additional, Thompson, Paul M., additional, Jahanshad, Neda, additional, Harmelen, Anne-Laura van, additional, Blumberg, Hilary P., additional, Schmaal, Lianne, additional, and Rentería, Miguel E., additional

Published
2021
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48. Treatment-related risk factors for inhibitor development in non-severe hemophilia A after 50 cumulative exposure days: a case-control study.

Author

UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service d'hématologie, Abdi, Amal, Eckhardt, Corien L, van Velzen, Alice S, Vuong, Caroline, Coppens, Michiel, Castaman, Giancarlo, Hart, Dan P, Hermans, Cédric, Laros-van Gorkom, Britta, Leebeek, Frank W G, Mancuso, Maria Elisa, Mazzucconi, Maria G, McRae, Simon, Oldenburg, Johannes, Male, Christoph, van der Bom, Johanna G, Fijnvandraat, Karin, Gouw, Samantha C, INSIGHT Study Group, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service d'hématologie, Abdi, Amal, Eckhardt, Corien L, van Velzen, Alice S, Vuong, Caroline, Coppens, Michiel, Castaman, Giancarlo, Hart, Dan P, Hermans, Cédric, Laros-van Gorkom, Britta, Leebeek, Frank W G, Mancuso, Maria Elisa, Mazzucconi, Maria G, McRae, Simon, Oldenburg, Johannes, Male, Christoph, van der Bom, Johanna G, Fijnvandraat, Karin, Gouw, Samantha C, and INSIGHT Study Group

Abstract

BACKGROUND: Non-severe hemophilia A patients have a life-long inhibitor risk. Yet, no studies analyzed risk factors for inhibitor development after 50 factor VIII (FVIII) exposure days (EDs). OBJECTIVES: This case-control study investigated treatment-related risk factors for inhibitor development in non-severe hemophilia A and assessed whether these risk factors were different for early versus late inhibitor development. PATIENTS/METHODS: Non-severe hemophilia A patients (FVIII:C 2-40%) were selected from the INSIGHT study. Inhibitor-positive patients were defined as early (<50 EDs) or late (> 50EDs) cases and matched to 1-4 inhibitor-negative controls by year of birth, cumulative number of EDs and center/country. We investigated treatment intensity during the last 10 EDs prior to inhibitor development. Intensive treatment was defined as: surgery, peak treatment (10 consecutive EDs) and high mean FVIII dose (>45 IU/kg/ED). Odds ratios (OR) were calculated by logistic regression. RESULTS: Of 2,709 patients, we analyzed 63 early and 26 late cases and 195 and 71 respectively matched controls. Peak treatment was associated with early and late inhibitor risk (crude OR 1.8, 95%CI 1.0-3.4; 4.0, 95%CI 1.1-14.3). This association was slightly less pronounced after adjustment for mean FVIII dose. High mean FVIII dose was also associated with early and late inhibitor risk (crude OR 2.8, 95%CI 1.5-5.1; 4.5, 95%CI 1.2-16.6). Surgery increased inhibitor risk for early cases. This was less pronounced for late cases. CONCLUSIONS: Our findings suggest that intensive FVIII treatment remains a risk factor for inhibitor development in non-severe hemophilia A after more than 50 EDs. Therefore, persistent caution is required throughout the life-time treatment course.

Published
2021

49. Cortical thickness and resting-state cardiac function across the lifespan : A cross-sectional pooled mega-analysis

Author

Koenig, Julian, Abler, Birgit, Agartz, Ingrid, Åkerstedt, Torbjörn, Andreassen, Ole A., Anthony, Mia, Bär, Karl-Jürgen, Bertsch, Katja, Brown, Rebecca C., Brunner, Romuald, Carnevali, Luca, Critchley, Hugo D., Cullen, Kathryn R., de Geus, Eco J. C., Dziobek, Isabel, Ferger, Marc D., Fischer, Håkan, Flor, Herta, Gaebler, Michael, Gianaros, Peter J., Giummarra, Melita J., Greening, Steven G., Guendelman, Simon, Heathers, James A. J., Herpertz, Sabine C., Hu, Mandy X., Jentschke, Sebastian, Kaess, Michael, Kaufmann, Tobias, Klimes-Dougan, Bonnie, Koelsch, Stefan, Krauch, Marlene, Kumral, Deniz, Lamers, Femke, Lee, Tae-Ho, Lekander, Mats, Lin, Feng, Lotze, Martin, Makovac, Elena, Mancini, Matteo, Mancke, Falk, Månsson, Kristoffer N.T., Manuck, Stephen B., Mather, Mara, Meeten, Frances, Min, Jungwon, Mueller, Bryon, Muench, Vera, Nees, Frauke, Nga, Lin, Nilsonne, Gustav, Ordonez Acuna, Daniela, Osnes, Berge, Ottaviani, Cristina, Penninx, Brenda W. J. H., Ponzio, Allison, Poudel, Govinda R., Reinelt, Janis, Ren, Ping, Sakaki, Michiko, Schumann, Andy, Sørensen, Lin, Specht, Karsten, Straub, Joana, Tamm, Sandra, Thai, Michelle, Thayer, Julian F., Ubani, Benjamin, van der Mee, Denise J., van Velzen, Laura S., Ventura-Bort, Carlos, Villringer, Arno, Watson, David R., Wei, Luqing, Wendt, Julia, Westlund Schreiner, Melinda, Westlye, Lars T., Weymar, Mathias, Winkelmann, Tobias, Wu, Guo-Rong, Yoo, Hyun Joo, Quintana, Daniel S., Koenig, Julian, Abler, Birgit, Agartz, Ingrid, Åkerstedt, Torbjörn, Andreassen, Ole A., Anthony, Mia, Bär, Karl-Jürgen, Bertsch, Katja, Brown, Rebecca C., Brunner, Romuald, Carnevali, Luca, Critchley, Hugo D., Cullen, Kathryn R., de Geus, Eco J. C., Dziobek, Isabel, Ferger, Marc D., Fischer, Håkan, Flor, Herta, Gaebler, Michael, Gianaros, Peter J., Giummarra, Melita J., Greening, Steven G., Guendelman, Simon, Heathers, James A. J., Herpertz, Sabine C., Hu, Mandy X., Jentschke, Sebastian, Kaess, Michael, Kaufmann, Tobias, Klimes-Dougan, Bonnie, Koelsch, Stefan, Krauch, Marlene, Kumral, Deniz, Lamers, Femke, Lee, Tae-Ho, Lekander, Mats, Lin, Feng, Lotze, Martin, Makovac, Elena, Mancini, Matteo, Mancke, Falk, Månsson, Kristoffer N.T., Manuck, Stephen B., Mather, Mara, Meeten, Frances, Min, Jungwon, Mueller, Bryon, Muench, Vera, Nees, Frauke, Nga, Lin, Nilsonne, Gustav, Ordonez Acuna, Daniela, Osnes, Berge, Ottaviani, Cristina, Penninx, Brenda W. J. H., Ponzio, Allison, Poudel, Govinda R., Reinelt, Janis, Ren, Ping, Sakaki, Michiko, Schumann, Andy, Sørensen, Lin, Specht, Karsten, Straub, Joana, Tamm, Sandra, Thai, Michelle, Thayer, Julian F., Ubani, Benjamin, van der Mee, Denise J., van Velzen, Laura S., Ventura-Bort, Carlos, Villringer, Arno, Watson, David R., Wei, Luqing, Wendt, Julia, Westlund Schreiner, Melinda, Westlye, Lars T., Weymar, Mathias, Winkelmann, Tobias, Wu, Guo-Rong, Yoo, Hyun Joo, and Quintana, Daniel S.

Abstract

Understanding the association between autonomic nervous system [ANS] function and brain morphology across the lifespan provides important insights into neurovisceral mechanisms underlying health and disease. Resting-state ANS activity, indexed by measures of heart rate [HR] and its variability [HRV] has been associated with brain morphology, particularly cortical thickness [CT]. While findings have been mixed regarding the anatomical distribution and direction of the associations, these inconsistencies may be due to sex and age differences in HR/HRV and CT. Previous studies have been limited by small sample sizes, which impede the assessment of sex differences and aging effects on the association between ANS function and CT. To overcome these limitations, 20 groups worldwide contributed data collected under similar protocols of CT assessment and HR/HRV recording to be pooled in a mega-analysis (N = 1,218 (50.5% female), mean age 36.7 years (range: 12–87)). Findings suggest a decline in HRV as well as CT with increasing age. CT, particularly in the orbitofrontal cortex, explained additional variance in HRV, beyond the effects of aging. This pattern of results may suggest that the decline in HRV with increasing age is related to a decline in orbitofrontal CT. These effects were independent of sex and specific to HRV; with no significant association between CT and HR. Greater CT across the adult lifespan may be vital for the maintenance of healthy cardiac regulation via the ANS—or greater cardiac vagal activity as indirectly reflected in HRV may slow brain atrophy. Findings reveal an important association between CT and cardiac parasympathetic activity with implications for healthy aging and longevity that should be studied further in longitudinal research.

Published
2021
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