1,175 results on '"Van Royen, P."'
Search Results
2. Risk factors for neurophysiological events related to intraoperative halo-femoral traction in spinal deformity surgery
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Berends, Hanneke I., Stadhouder, Agnita, van Royen, Barend J., Journée, Henricus L., and Gouw, Alida A.
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- 2024
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3. A Systematic Review and Meta-analysis of the Effectiveness of Dietary Interventions to Enhance Mental Wellbeing in Emerging Adulthood
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DeSmet, Ann, Culot, Catherine, Virani, Devintha, Pabian, S., Ariño Mateo, Eva, Van Royen, Kathleen, Oenema, Anke, and Liebmann, Margaux
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- 2024
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4. LRP10 and α-synuclein transmission in Lewy body diseases
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Carreras Mascaro, Ana, Grochowska, Martyna M., Boumeester, Valerie, Dits, Natasja F. J., Bilgiҫ, Ece Naz, Breedveld, Guido J., Vergouw, Leonie, de Jong, Frank Jan, van Royen, Martin E., Bonifati, Vincenzo, and Mandemakers, Wim
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- 2024
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5. Validation of resting full-cycle ratio and diastolic pressure ratio with [15O]H2O positron emission tomography myocardial perfusion
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Dahdal, Jorge, Bakker, Frank, Svanerud, Johan, Danad, Ibrahim, Driessen, Roel S., Raijmakers, Pieter G., Harms, Hendrik J., Lammertsma, Adriaan A., van de Hoef, Tim P., Appelman, Yolande, van Royen, Niels, Knaapen, Paul, and de Waard, Guus A.
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- 2024
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6. Functional and morphological improvement of significant non-culprit coronary artery stenosis by LDL-C reduction with a PCSK9 antibody: Rationale and design of the randomized FITTER trial
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Frans B. Mensink, Jonathan Los, Rohit M. Oemrawsingh, Clemens von Birgelen, Alexander Ijsselmuiden, Martijn Meuwissen, Jin M. Cheng, Diederik F. van Wijk, Pieter C. Smits, Valeria Paradies, Dirk J. van der Heijden, Himanshu Rai, Tim JF. ten Cate, Cyril Camaro, Peter Damman, Lokien X. van Nunen, Aukelien C. Dimitriu-Leen, Marleen H. van Wely, Aysun Cetinyurek-Yavuz, Robert A. Byrne, Niels van Royen, and Robert-Jan M. van Geuns
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Acute coronary syndrome (ACS) ,Multivessel disease (MVD) ,Fractional flow reserve (FFR) ,Intravascular ultrasound (IVUS) ,Near-infrared spectroscopy (NIRS) ,Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Non-culprit coronary artery lesions are commonly present in patients presenting with an acute coronary syndrome (ACS). Additional stenting of non-culprit lesions in addition to the culprit lesion intends to prevent secondary events caused by these lesions. At the same time, multiple trials have demonstrated the potential of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors in reducing plaque size and changing plaque composition of non-culprit lesions. Whether intensive low-density lipoprotein cholesterol (LDL-C) reduction with PCSK9 inhibitor evolocumab improves non-culprit vessel hemodynamics, reduces the risk of plaque rupture of important non-culprit lesions, and might obviate the need for additional stenting has not been investigated. The “Functional Improvement of non‐infarcT related coronary artery stenosis by Extensive LDL‐C Reduction with a PCSK9 Antibody” (FITTER) trial is a multi-center, randomized, double-blind, placebo-controlled clinical trial for patients presenting with ACS and multivessel disease (MVD). After treatment of the culprit lesion, fractional flow reserve (FFR) is performed in non-culprit vessels amenable for percutaneous coronary intervention (PCI). Coronary intervention in patients with hemodynamically important non-critical lesions (FFR: 0.67–0.85) is staged after baseline imaging using near-infrared spectroscopy (NIRS) and intravascular ultrasound (IVUS). Eligible patients are randomized and treated for 12 weeks with either evolocumab or placebo, in addition to high-intensity statin therapy. Follow-up angiography with repeat FFR and IVUS-NIRS is scheduled at 12 weeks. Staged PCI is performed at the operator's discretion.The FITTER trial is the first study to evaluate the effect of maximal LDL-C reduction by the PCSK9 inhibitor evolocumab on invasively measured FFR, plaque size, and plaque composition in hemodynamically important non-culprit lesions, during a treatment period of just 12 weeks after an ACS. Currently, all patients have been included (August 2023) and data analysis is ongoing. Trial registration number: clinicaltrials.gov NCT04141579.
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- 2024
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7. Periprocedural Assessment of Paravalvular Regurgitation After Transcatheter Aortic Valve Replacement Using Diastolic Delta and Videodensitometry
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Maxim J. P. Rooijakkers, Ahmed Elkoumy, Niels A. Stens, Marleen H. van Wely, Geert A. A. Versteeg, Tsung‐Ying Tsai, Laura Rodwell, Robin H. Heijmen, Patrick W. Serruys, Osama Soliman, and Niels van Royen
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aortic stenosis ,cardiac magnetic resonance ,paravalvular regurgitation ,transcatheter aortic valve replacement ,videodensitometry ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Paravalvular regurgitation (PVR) is a common complication after transcatheter aortic valve replacement, posing an increased risk of heart failure and mortality. Accurate intraprocedural quantification of PVR is challenging. Both hemodynamic indices and videodensitometry can be used for intraprocedural assessment of PVR. We compared the predictive value of the isolated versus combined use of the hemodynamic index diastolic delta (DD) and videodensitometry for the incidence of relevant PVR 1 month after transcatheter aortic valve replacement. Methods and Results In this prospective cohort study, patients underwent periprocedural PVR assessment by DD and videodensitometry (using left ventricular outflow tract—aortic regurgitation [LVOT‐AR]). Cardiac magnetic resonance served as reference modality for PVR assessment. Relevant PVR was defined as cardiac magnetic resonance–regurgitant fraction >20%. Fifty‐one patients were enrolled in this study. Mean age was 80.6±5.2 years and 45.1% of patients were men. Mean LVOT‐AR and cardiac magnetic resonance–regurgitant fraction were 8.2%±7.8% and 11.7%±9.6%, respectively. The correlation between DD and LVOT‐AR was weak (r=−0.36). DD and LVOT‐AR showed a comparable accuracy to predict relevant PVR (area under the curve 0.82, 95% CI: 0.69–0.95 versus area area under the time–density curve 0.80, 95% CI: 0.62–0.99). The combination of DD and LVOT‐AR improved the prediction of relevant PVR (area under the time–density curve, 0.90, 95% CI: 0.81–0.99), and resulted in an increased concordance (86.3%) and positive predictive value (75%) compared with DD alone (76.5% and 40%, respectively), or LVOT‐AR alone (82.3% and 50%, respectively). Conclusions DD and videodensitometry are both accurate and feasible modalities for the assessment of PVR after transcatheter aortic valve replacement. The synergistic use of both techniques increases the predictive value for relevant PVR after transcatheter aortic valve replacement. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT04281771.
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- 2024
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8. The SW480 cell line as a model of resident and migrating colon cancer stem cells
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Mathijs P. Verhagen, Tong Xu, Roberto Stabile, Rosalie Joosten, Francesco A. Tucci, Martin van Royen, Marco Trerotola, Saverio Alberti, Andrea Sacchetti, and Riccardo Fodde
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molecular biology ,cell biology ,cancer ,transcriptomics ,Science - Abstract
Summary: Intra-tumor heterogeneity, i.e., the presence of diverse cell types and subpopulations within tumors, presents a significant obstacle in cancer treatment due to its negative consequences for resistance to therapy and disease recurrence. However, the mechanisms that underlie intra-tumor heterogeneity and result in the plethora of different cancer cells within a single lesion remain poorly understood. Here, we leverage the SW480 cell line as a model system to investigate the molecular and functional diversity of colon cancer cells. Through a combination of fluorescence-activated cell sorting (FACS) analysis and transcriptomic profiling, we identified three distinct subpopulations, namely resident cancer stem cells (rCSCs), migratory CSCs (mCSCs), and high-relapse cells (HRCs). These subpopulations show varying Wnt signaling levels and gene expression profiles mirroring their stem-like and functional properties. Examination of publicly available spatial transcriptomic data confirms the presence of these subpopulations in patient-derived cancers and reveals their distinct spatial distribution relative to the tumor microenvironment.
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- 2024
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9. Percutaneous coronary intervention in patients undergoing transcatheter aortic valve implantation: a systematic review and meta-analysis
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Aarts, Hugo M., van Hemert, Nicole D., Meijs, Timion A., van Nieuwkerk, Astrid C., Berg, Jurriën M. ten, Wykrzykowska, Joanna J., van Royen, Niels, Schotborgh, Carl E., Tonino, Pim A. L., IJsselmuiden, Alexander, Vossenberg, Tessel N., van Houwelingen, Gert K., Slagboom, Ton, Voskuil, Michiel, and Delewi, Ronak
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- 2023
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10. Impact of stenosis resistance and coronary flow capacity on fractional flow reserve and instantaneous wave-free ratio discordance: a combined analysis of DEFINE-FLOW and IDEAL
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Stegehuis, Valérie, Boerhout, Coen, Kikuta, Yuetsu, Cambero-Madera, Maribel, van Royen, Niels, Matsuo, Hitoshi, Nakayama, Masafumi, de Waard, Guus, Knaapen, Paul, Nijjer, Sukhjinder, Petraco, Ricardo, Siebes, Maria, Davies, Justin, Escaned, Javier, van de Hoef, Tim, and Piek, Jan
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- 2023
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11. The role of early maladaptive schemas in late adolescents suffering from school burnout and depressive symptoms
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Annelies Van Royen, Laura Wante, and Caroline Braet
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School burnout ,Depressive symptoms ,Late adolescents ,Early maladaptive schema ,Mental healing ,RZ400-408 - Abstract
Background: The present study aims to distinguish school burnout from depressive symptoms in late adolescents between 17 and 21 years old by exploring their underlying early maladaptive schemas (EMS). Methods: The cross-sectional sample (T1) consisted of 514 secondary and higher education students between 17 and 21 years old (Mage = 19.06 (1.10), 80.9% female). Five months later (T2), 190 adolescents participated in the follow-up measurement (Mage = 19.45 (1.18), 81.6% female). Results: Positive correlations were found between all EMS and school burnout symptoms. When controlling for school burnout symptoms at T1, only the EMS `emotional deprivation', `mistrust', `defectiveness', `social isolation', `failure', `enmeshment', and `emotional inhibition' displayed significant positive associations with school burnout at T2. The EMS `mistrust', `defectiveness' and `failure' showed relations to both school burnout and depressive symptoms. Backwards linear regressions showed that the EMS `vulnerability to harm/illness' and `insufficient self-control' were uniquely related to school burnout symptoms when controlling for depressive symptoms, while the EMS `dependence', `emotional deprivation', `self-sacrifice' and `unrelenting standards' were uniquely related to depressive symptoms while controlling for school burnout symptoms. Limitations: The gender-unbalanced sample, reduced longitudinal sample size, sole use of self-report measures, and high comorbidity between school burnout and depressive symptoms may have hampered the results. Conclusions: EMS play an important role in the development of school burnout symptoms. The results point towards transdiagnostic cognitive-focused treatment techniques with attention to disorder-specific schemas to tackle school burnout symptoms. More (longitudinal) research is needed to corroborate these initial findings.
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- 2024
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12. Arthroscopic Volar Extrinsic Plicature of the Volar Extrinsic Ligaments for Chronic Volar Scapholunate Instability
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Chul Ki Goorens, M.D., Kjell Van Royen, M.D., and Andrea Atzei, M.D.
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Orthopedic surgery ,RD701-811 - Abstract
The scapholunate ligamentous complex consists of the scapholunate interosseous ligament and the surrounding extrinsic ligamentous system. In cases of chronic scapholunate instability, stabilizing the extrinsic ligaments is crucial. This article presents an arthroscopic capsuloligamentous reinforcement plicature that focuses on tightening the volar scapholunate extrinsic ligaments, namely the radioscaphocapitate ligament and long radiolunate ligament, along with indirect tightening of the volar scapholunate interosseous ligament. Although it may be challenging to differentiate the effect of the volar extrinsic plicature from a dorsal capsular reinforcement when both are applied, the volar extrinsic plicature can serve as a beneficial addition to dorsal capsular reinforcement techniques for complex scapholunate instability.
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- 2024
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13. Medical Care Use Among Patients with Monogenic Osteoporosis Due to Rare Variants in LRP5, PLS3, or WNT1
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Verdonk, S. J. E., Storoni, S., Zhytnik, L., Zhong, W., Pals, G., van Royen, B. J., Elting, M. W., Maugeri, A., Eekhoff, E. M. W., and Micha, D.
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- 2023
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14. Phase Separation Mediated Sub-Nuclear Compartmentalization of Androgen Receptors
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Selçuk Yavuz, Tsion E. Abraham, Adriaan B. Houtsmuller, and Martin E. van Royen
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nuclear receptors ,subnuclear compartmentalization ,gene transcription regulation ,liquid–liquid phase separation ,prostatic neoplasms ,Cytology ,QH573-671 - Abstract
The androgen receptor (AR), a member of the nuclear steroid hormone receptor family of transcription factors, plays a crucial role not only in the development of the male phenotype but also in the development and growth of prostate cancer. While AR structure and AR interactions with coregulators and chromatin have been studied in detail, improving our understanding of AR function in gene transcription regulation, the spatio-temporal organization and the role of microscopically discernible AR foci in the nucleus are still underexplored. This review delves into the molecular mechanisms underlying AR foci formation, focusing on liquid–liquid phase separation and its role in spatially organizing ARs and their binding partners within the nucleus at transcription sites, as well as the influence of 3D-genome organization on AR-mediated gene transcription.
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- 2024
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15. A rare electrocardiographic sign of acute inferior myocardial infarction
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Hoevenaars, Mirte, van Geuns, Robert J., van Royen, Niels, and Damman, Peter
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- 2024
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16. Imatinib attenuates reperfusion injury in a rat model of acute myocardial infarction
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Konijnenberg, Lara S. F., Luiken, Tom T. J., Veltien, Andor, Uthman, Laween, Kuster, Carolien T. A., Rodwell, Laura, de Waard, Guus A., Kea-te Lindert, Mariska, Akiva, Anat, Thijssen, Dick H. J., Nijveldt, Robin, and van Royen, Niels
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- 2023
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17. Abnormal physiological findings after FFR-based revascularisation deferral are associated with worse prognosis in women
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Hoshino, Masahiro, van de Hoef, Tim P., Lee, Joo Myung, Hamaya, Rikuta, Kanaji, Yoshihisa, Boerhout, Coen K. M., de Waard, Guus A., Jung, Ji-Hyun, Lee, Seung Hun, Mejia-Renteria, Hernan, Echavarria-Pinto, Mauro, Meuwissen, Martijn, Matsuo, Hitoshi, Madera-Cambero, Maribel, Eftekhari, Ashkan, Effat, Mohamed A., Marques, Koen, Doh, Joon-Hyung, Christiansen, Evald H., Banerjee, Rupak, Nam, Chang-Wook, Niccoli, Giampaolo, Murai, Tadashi, Nakayama, Masafumi, Tanaka, Nobuhiro, Shin, Eun-Seok, Sasano, Tetsuo, Appelman, Yolande, Beijk, Marcel, Knaapen, Paul, van Royen, Niels, Escaned, Javier, Koo, Bon Kwon, Piek, Jan J., and Kakuta, Tsunekazu
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- 2023
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18. Perceived barriers, benefits, facilitators, and attitudes of health professionals towards type 2 diabetes management in Oujda, Morocco: a qualitative focus group study
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Dankoly, Usman Sani, Vissers, Dirk, El Mostafa, Souad Ben, Ziyyat, Abderrahim, Van Rompaey, Bart, Van Royen, Paul, and Maamri, Abdellatif
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- 2023
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19. Two‐Week Interruption of Statin Therapy Results in an Exaggerated Inflammatory Monocyte Phenotype in Young Patients With Myocardial Infarction Without Standard Modifiable Risk Factors
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Jan‐Quinten Mol, Julia van Tuijl, Siroon Bekkering, Laura Rodwell, Gheorghe A. M. Pop, Mihai G. Netea, Niels van Royen, Niels P. Riksen, and Saloua El Messaoudi
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inflammation ,monocytes ,myocardial infarction ,standard modifiable risk factors ,statins ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2024
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20. Predictive factors of clot propagation in patients with superficial venous thrombosis towards deep venous thrombosis and pulmonary embolism: a systematic review and meta-analysis
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Frans H Rutten, Geert-Jan Geersing, Sander van Doorn, Maarten van Smeden, and Florien Sophie-Anne van Royen
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Medicine - Abstract
Objective A subset of patients with superficial venous thrombosis (SVT) experiences clot propagation towards deep venous thrombosis (DVT) and/or pulmonary embolism (PE). The aim of this systematic review is to identify all clinically relevant cross-sectional and prognostic factors for predicting thrombotic complications in patients with SVT.Design Systematic review.Data sources PubMed/MEDLINE and Embase were systematically searched until 3 March 2023.Eligibility criteria Original research studies with patients with SVT, DVT and/or PE as the outcome and presenting cross-sectional or prognostic predictive factors.Data extraction and synthesis of results The CHecklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling (CHARMS) checklist for prognostic factor studies was used for systematic extraction of study characteristics. Per identified predictive factor, relevant estimates of univariable and multivariable predictor—outcome associations were extracted, such as ORs and HRs. Estimates of association for the most frequently reported predictors were summarised in forest plots, and meta-analyses with heterogeneity were presented. The Quality in Prognosis Studies (QUIPS) tool was used for risk of bias assessment and Grading of Recommendations, Assessment, Development and Evaluations (GRADE) for assessing the certainty of evidence.Results Twenty-two studies were included (n=10 111 patients). The most reported predictive factors were high age, male sex, history of venous thromboembolism (VTE), absence of varicose veins and cancer. Pooled effect estimates were heterogenous and ranged from OR 3.12 (95% CI 1.75 to 5.59) for the cross-sectional predictor cancer to OR 0.92 (95% CI 0.56 to 1.53) for the prognostic predictor high age. The level of evidence was rated very low to low. Most studies were scored high or moderate risk of bias.Conclusions Although the pooled estimates of the predictors high age, male sex, history of VTE, cancer and absence of varicose veins showed predictive potential in isolation, variability in study designs, lack of multivariable adjustment and high risk of bias prevent firm conclusions. High-quality, multivariable studies are necessary to be able to identify individual SVT risk profiles.PROSPERO registration number CRD42021262819.
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- 2024
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21. Associations of Lifelong Exercise Characteristics With Valvular Function and Aortic Diameters in Patients With a Bicuspid Aortic Valve
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Bibi A. Schreurs, Maria T. E. Hopman, Chantal M. Bakker, Anthonie L. Duijnhouwer, Niels van Royen, Paul D. Thompson, Roland R. J. van Kimmenade, and Thijs M. H. Eijsvogels
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aorta ,aortic regurgitation ,aortic stenosis ,aortic valve ,bicuspid aortic valve disease ,exercise ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background The potential impact of exercise on valvular function and aortic diameters in patients with a bicuspid aortic valve remains unclear. Therefore, we assessed the association between lifelong exercise characteristics, valvular dysfunction, and aortic dilatation in patients with a bicuspid aortic valve. Methods and Results In this cross‐sectional study, exercise volume (metabolic equivalent of task minutes per week), exercise intensity, and sport type were determined from the age of 12 years to participation using a validated questionnaire. Echocardiography was used to assess aortic stenosis or aortic regurgitation and to measure diameters at the sinuses of Valsalva and ascending aorta. Aortic dilatation was defined as a Z‐score ≥2. Four hundred and seven patients (42±17 years, 60% men) were included, of which 133 were sedentary (
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- 2024
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22. Invasive coronary imaging of inflammation to further characterize high-risk lesions: what options do we have?
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Jonathan Los, Frans B. Mensink, Niekbachsh Mohammadnia, Tjerk S. J. Opstal, Peter Damman, Rick H. J. A. Volleberg, Denise A. M. Peeters, Niels van Royen, Hector M. Garcia-Garcia, Jan H. Cornel, Saloua El Messaoudi, and Robert-Jan M. van Geuns
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atherosclerosis ,inflammation ,intravascular ultrasound ,near-infrared spectroscopy ,optical coherence tomography ,near-infrared fluorescence imaging ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Coronary atherosclerosis remains a leading cause of morbidity and mortality worldwide. The underlying pathophysiology includes a complex interplay of endothelial dysfunction, lipid accumulation and inflammatory pathways. Multiple structural and inflammatory features of the atherosclerotic lesions have become targets to identify high-risk lesions. Various intracoronary imaging devices have been developed to assess the morphological, biocompositional and molecular profile of the intracoronary atheromata. These techniques guide interventional and therapeutical management and allow the identification and stratification of atherosclerotic lesions. We sought to provide an overview of the inflammatory pathobiology of atherosclerosis, distinct high-risk plaque features and the ability to visualize this process with contemporary intracoronary imaging techniques.
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- 2024
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23. Perspectives and Attitudes of General Practitioners Towards Pharmacological and Non-Pharmacological COPD Management in a Belgian Primary Care Setting: A Qualitative Study
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Leemans G, Vissers D, Ides K, and Van Royen P
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asthma/copd management ,family medicine ,non-pharmacologic treatment ,pulmonary rehabilitation ,interdisciplinary care ,thematic analysis ,Diseases of the respiratory system ,RC705-779 - Abstract
Glenn Leemans,1 Dirk Vissers,1 Kris Ides,2– 4 Paul Van Royen5 1Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium; 2Cosys-Lab, Flanders Make, University of Antwerp, Antwerp, Belgium; 3Laboratory of Experimental Medicine and Pediatrics, Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium; 4Department of Pediatrics, Antwerp University Hospital, Edegem, Belgium; 5Department of Family Medicine and Population Health, University of Antwerp, Wilrijk, BelgiumCorrespondence: Glenn Leemans, Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Sciences, University of Antwerp, Universiteitsplein 1, Wilrijk, 2610, Belgium, Tel +32 495 34 84 59, Email glenn.leemans@student.uantwerpen.beBackground: Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous condition that requires multidisciplinary management. In Belgium, the treatment of COPD is mainly managed by general practitioners (GPs). Several clinical practice guidelines (CPGs) recommend the use of non-pharmacological treatments, such as pulmonary rehabilitation, and interdisciplinary care for COPD patients. Although considerable research has been devoted to addressing the multitude of reasons for the lack of adherence to these aspects of the CPGs, less attention has been paid to understanding the perspectives and attitudes of GPs that lead to this suboptimal implementation.Purpose: This study aimed to 1) explore Belgian GPs’ perceptions regarding COPD management in a primary care setting and 2) collect their views on the importance of pulmonary rehabilitation and interprofessional care in COPD management.Methods: A descriptive study, conducted between August 2014 and May 2015, used interviews from a sample of 30 Flemish GPs. Data were analyzed following the principles of thematic analysis.Results: COPD management was patient-centered, focusing on immediate symptom relief and reducing future risks through pharmacotherapy and proper patient education. Deviations from the CPGs were noted, with only a few GPs performing spirometry themselves. Conditions to prescribe respiratory physiotherapy were not well known. Some GPs remained unconvinced about the (cost-)effectiveness of respiratory physiotherapy despite the fast-expanding scientific evidence. Interprofessional care was limited to GP-respiratory physician (re)-referral and communication. GPs showed a reactive attitude towards interprofessional collaboration for non-pharmacological therapies, which is not in line with the proactive approach recommended in CPGs.Conclusion: GPs managed COPD patients mainly by reducing symptoms with pharmacological therapy. Integrated care regarding non-pharmacological treatments was not well implemented due to the obstacles in interprofessional collaboration. Future care models incorporating personalized care planning could provide a solution to manage COPD’s complex healthcare demands.Keywords: asthma/COPD management, family medicine, non-pharmacologic treatment, pulmonary rehabilitation, interdisciplinary care, thematic analysis
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- 2023
24. Estimated cumulative radiation exposure in patients treated for adolescent idiopathic scoliosis
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Cool, J., Streekstra, G. J., van Schuppen, J., Stadhouder, A., van den Noort, J. C., and van Royen, B. J.
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- 2023
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25. Current models to understand the onset and progression of scoliotic deformities in adolescent idiopathic scoliosis: a systematic review
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Meiring, A. R., de Kater, E. P., Stadhouder, A., van Royen, B. J., Breedveld, P., and Smit, T. H.
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- 2023
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26. Mass production and characterization of 3-inch PMTs for the JUNO experiment
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Cao, Chuanya, Xu, Jilei, He, Miao, Abusleme, Angel, Bongrand, Mathieu, Bordereau, Clément, Breton, Dominique, Cabrera, Anatael, Campeny, Agustin, Cerna, Cédric, Chen, Haoqiang, Chen, Po-An, Claverie, Gérard, Di Lorenzo, Selma Conforti, De La Taille, Christophe, Druillole, Frédéric, Fournier, Amélie, Grassi, Marco, Gu, Xiaofei, Haacke, Michael, Han, Yang, Hellmuth, Patrick, Heng, Yuekun, Herrera, Rafael, Hsiung, Yee, Hu, Bei-Zhen, Huang, Yongbo, Huss, Cédric, Jeria, Ignacio, Jing, Xiaoping, Jollet, Cécile, Lebrin, Victor, Lefère, Frédéric, Li, Hongwei, Li, Nan, Liu, Hongbang, Liu, Xiwen, Lubsandorzhiev, Bayarto, Lubsandorzhiev, Sultim, Lukanov, Arslan, Maalmi, Jihane, Meregaglia, Anselmo, Navas-Nicolas, Diana, Ochoa-Ricoux, Juan Pedro, Perrot, Frédéric, Rajan, Rebin Karaparambil, Rebii, Abdel, Roskovec, Bedřich, Santos, Cayetano, Settimo, Mariangela, Sidorenkov, Andrey, Tkachev, Igor, Troni, Giancarlo, Ushakov, Nikita, Van Royen, Guillaume, Viaud, Benoit, Voronin, Dmitriy, Walker, Pablo, Wang, Chung-Hsiang, Wang, Zhimin, Wu, Diru, Xu, Hangkun, Xu, Meihang, Yang, Chengfeng, Yang, Jie, Yermia, Frédéric, and Zhang, Xuantong
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
26,000 3-inch photomultiplier tubes (PMTs) have been produced for Jiangmen Underground Neutrino Observatory (JUNO) by the Hainan Zhanchuang Photonics Technology Co., Ltd (HZC) company in China and passed all acceptance tests with only 15 tubes rejected. The mass production began in 2018 and elapsed for about 2 years at a rate of $\sim$1,000~PMTs per month. The characterization of the PMTs was performed in the factory concurrently with production as a joint effort between HZC and JUNO. Fifteen performance parameters were tracked at different sampling rates, and novel working strategies were implemented to improve quality assurance. This constitutes the largest sample of 3-inch PMTs ever produced and studied in detail to date.
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- 2021
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27. Fusionless treatment of adolescent idiopathic scoliosis: Early results of a prospective cohort study
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M. Post, E. Janssen, and B. Van Royen
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Neurology. Diseases of the nervous system ,RC346-429 - Published
- 2024
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28. One-way self-expanding rods for early onset neuromuscular scoliosis: 2-year follow-up on an international cohort
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M. Post, M. Gaume, B. Van Royen, E. Janssen, K. Lundine, M. Johnson, M. Kruyt, A. Stadhouder, J.P. Kaleeta Maalu, and L. Miladi
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Neurology. Diseases of the nervous system ,RC346-429 - Published
- 2024
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29. Evaluation of Cardiac Function and Infarct Size by Contrast-enhanced Cardiac Magnetic Resonance Imaging in Mice with Myocardial Ischemia Reperfusion Injury: Comparison of Imaging and Staining Data
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Panagiota-Efstathia Nikolaou, PhD, MSc, Lara Konijnenberg, MD, Carolien Kuster, Vince van Reijmersdal, MSc, Andor Veltien, BSc, Ioanna Andreadou, PhD, MSc, Niels van Royen, MD, PhD, and Robin Nijveldt, MD, PhD, FSCMR
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2024
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30. Evaluation of Endpoints in Ischemia Reperfusion Injury by CMR in an in vivo Rat Model of Acute Myocardial Infarction
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Carolien Kuster, MSc, Lara Konijnenberg, MD, Andor Veltien, BSc, Vince van Reijmersdal, MSc, Niels van Royen, MD, PhD, and Robin Nijveldt, MD, PhD, FSCMR
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2024
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31. Minimally Invasive Posterior Spinal Nonfusion Surgery in Patients With Adolescent Idiopathic Scoliosis Using a Bipolar One-Way Self-Expanding Rod System: Protocol for a Single-Center Clinical Cohort Study
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Anne Mareille Post, Hanneke I Berends, and Barend J van Royen
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Medicine ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
BackgroundThe current surgical treatment for patients diagnosed with progressive and severe adolescent idiopathic scoliosis (AIS) consists of the correction of the spinal curvature, followed by posterior spinal fusion (PSF). However, research has uncovered short- and long-term complications of posterior spinal fusion in patients with AIS. Minimally invasive growing rod techniques have successfully been used to treat patients with early-onset scoliosis and neuromuscular scoliosis. It may be questioned if minimally invasive posterior spinal nonfusion (PSnF) surgery with bipolar instrumentation can be used for the treatment of AIS. ObjectiveThis study will be performed to monitor the efficacy and safety of PSnF surgery by using a commercially available Conformité Européenne-certified spinal implant consisting of bilateral bipolar one-way self-expanding rods (OWSER) for the treatment of patients diagnosed with AIS. MethodsIn 14 selected patients with AIS with Lenke 1-6 curves, minimally invasive PSnF surgery with the OWSER system is performed after the failure of conservative treatment (curve progression of >5° within 1 year). The patients are over 7 years of age, with a major Cobb angle of ≥30°, sufficient flexibility, and a Risser stage of ≤2. Patients will be followed over time, according to the standard medical care. Efficacy will be measured using radiological and patient satisfaction assessments and safety will be determined by the amount of perioperative complications. ResultsPatient inclusion started on November 17, 2021 and we hope to finalize patient inclusion by the beginning of 2025. The first results will be expected by the beginning of 2024. ConclusionsMinimally invasive PSnF in patients with AIS is presented as a less invasive surgical technique that prevents the progression of the scoliotic curve and that allows minor posture correction of coronal imbalance. This will be the first study to examine whether the PSnF bipolar OWSER instrumentation will be the next generation of surgical instrumentation in AIS. Trial RegistrationClinicalTrials.gov NCT04441411; https://clinicaltrials.gov/study/NCT04441411 International Registered Report Identifier (IRRID)DERR1-10.2196/47222
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- 2023
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32. Biologicals for pediatric patients with atopic dermatitis: practical challenges and knowledge gaps
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Lisa P. van der Rijst, Annet van Royen-Kerkhof, Suzanne G. M. A. Pasmans, Renske Schappin, Marjolein S. de Bruin-Weller, and Marlies de Graaf
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atopic dermatitis ,biological therapy ,pediatric dermatology ,immunomodulating therapy ,children ,Dermatology ,RL1-803 - Abstract
Biologicals are becoming increasingly important in the therapeutic landscape of pediatric patients with moderate-to-severe atopic dermatitis (AD). Currently, dupilumab and tralokinumab are registered for the treatment of moderate-to-severe AD, and novel biologicals are expected to follow. Dupilumab was the first biological registered for AD in pediatric patients and was recently approved for patients aged six months to five years. Current and emerging biologicals may address the unmet need for effective and safe treatment options for pediatric AD patients, however, little is known about the practical implementation of biologicals in infants and preschoolers (aged
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- 2023
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33. Differences in risk and costs between prehospital identified low-risk men and women with chest pain
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Roland R J van Kimmenade, Niels van Royen, Eddy M M Adang, Goaris W A Aarts, Cyril Camaro, Martijn Rutten, Marc E R Gomes, Gilbert E Cramer, Peter Damman, Robert-Jan M Van Geuns, Laura Rodwell, Roger van Hout, Gijs Brok, Anouk Hoare, Frank P C de Pooter, Walter de Wit, Eva Ouwendijk, and Erwin Zegers
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Objective Prehospital rule-out of non-ST-segment elevation acute coronary syndrome (NSTE-ACS) in low-risk patient with a point-of-care troponin measurement reduces healthcare costs with similar safety to standard transfer to the hospital. Risk stratification is performed identical for men and women, despite important differences in clinical presentation, risk factors and age between men and women with NSTE-ACS. Our aim was to compare safety and healthcare costs between men and women in prehospital identified low-risk patients with suspected NSTE-ACS.Methods In the Acute Rule-out of non-ST-segment elevation acute coronary syndrome in the (pre)hospital setting by HEART (History, ECG, Age, Risk factors and Troponin) score assessment and a single poInt of CAre troponin randomised trial, the HEAR (History, ECG, Age and Risk factors) score was assessed by ambulance paramedics in suspected NSTE-ACS patients. Low-risk patients (HEAR score ≤3) were included. In this substudy, men and women were compared. Primary endpoint was 30-day major adverse cardiac events (MACE), secondary endpoints were 30-day healthcare costs and the scores for the HEAR score components.Results A total of 863 patients were included, of which 495 (57.4%) were women. Follow-up was completed in all patients. In the total population, MACE occurred in 6.8% of the men and 1.6% of the women (risk ratio (RR) 4.2 (95% CI 1.9 to 9.2, p
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- 2023
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34. Call for emergency action to restore dietary diversity and protect global food systems in times of COVID-19 and beyond: Results from a cross-sectional study in 38 countries
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Maha Hoteit, Reem Hoteit, Ayoub Aljawaldeh, Kathleen Van Royen, Sara Pabian, Paulien Decorte, Isabelle Cuykx, Lauranna Teunissen, Charlotte De Backer, Ina Bergheim, Raphaela Staltner, Amanda Devine, Ros Sambell, Ruth Wallace, Sabika Salem Allehdan, Tariq Abdulkarim Alalwan, Mariam Ahamad Al-Mannai, Gaëlle Ouvrein, Karolien Poels, Heidi Vandebosch, Katrien Maldoy, Christophe Matthys, Tim Smits, Jules Vrinten, Ann DeSmet, Nelleke Teughels, Maggie Geuens, Iris Vermeir, Viktor Proesmans, Liselot Hudders, Marcia Dutra De Barcellos, Cristina Ostermann, Ana Luiza Brock, Cynthia Favieiro, Rafaela Trizotto, Isadora Stangherlin, Anthonieta Looman Mafra, Marco Antônio Correa Varella, Jaroslava Varella Valentova, Maryanne L. Fisher, Melanie MacEacheron, Katherine White, Rishad Habib, David S. Dobson, Berta Schnettler, Ligia Orellana, Edgardo Miranda-Zapata, Angela Wen-Yu Chang, Wen Jiao, Matthew Tingchi Liu, Klaus G. Grunert, Rikke Nyland Christensen, Lucia Reisch, Meike Janssen, Victoria Abril-Ulloa, Lorena Encalada, Iman Kamel, Annukka Vainio, Mari Niva, Laura Salmivaara, Johanna Mäkelä, Kaisa Torkkeli, Robert Mai, Pamela Kerschke Risch, Efthymios Altsitsiadis, Angelos Stamos, Andreas Antronikidis, Maeve Henchion, Sinead McCarthy, Mary McCarthy, Alessandra Micalizzi, Peter J. Schulz, Manuela Farinosi, Hidenori Komatsu, Nobuyuki Tanaka, Hiromi Kubota, Reema Tayyem, Narmeen J. Al-Awwad, Nahla Al-Bayyari, Mohammed O. Ibrahim, Fadwa Hammouh, Somaia Dashti, Basma Dashti, Dhuha Alkharaif, Amani Alshatti, Maryam Al Mazedi, Rania Mansour, Elissa Naim, Hussein Mortada, Yareni Yunuen Gutierrez Gomez, Kelly Geyskens, Caroline Goukens, Rajshri Roy, Victoria Egli, Lisa Te Morenga, Mostafa Waly, Radwan Qasrawi, Motasem Hamdan, Rania Abu Sier, Diala Abu Al Halawa, Hazem Agha, María Reyna Liria Domínguez, Lita Palomares, Grazyna Wasowicz, Hiba Bawadi, Manal Othman, Jaafar Pakari, Allam Abu Farha, Rasha Abu-El-Ruz, Dacinia Crina Petrescu, Ruxandra Malina Petrescu Mag, Felix Arion, Stefan Cristian Vesa, Majid M. Alkhalaf, Khlood Bookari, Jamila Arrish, Zackaria Rahim, Roy Kheng, Yandisa Ngqangashe, Zandile June-Rose Mchiza, Marcela Gonzalez-Gross, Lisset Pantoja-Arévalo, Eva Gesteiro, Yolanda Ríos, Peter Yiga, Patrick Ogwok, Denis Ocen, Michael Bamuwamye, Haleama Al Sabbah, Zainab Taha, Leila Cheikh Ismail, Ayesha Aldhaheri, Elisa Pineda, Marisa Miraldo, Dawn Liu Holford, and Hilde Van den Bulck
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COVID-19 ,Pandemics ,Food consumption pattern ,Dietary diversity ,Food consumption score ,Food-related behaviors ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Background: The COVID-19 pandemic has revealed the fragility of the global food system, sending shockwaves across countries' societies and economy. This has presented formidable challenges to sustaining a healthy and resilient lifestyle. The objective of this study is to examine the food consumption patterns and assess diet diversity indicators, primarily focusing on the food consumption score (FCS), among households in 38 countries both before and during the first wave of the COVID-19 pandemic. Methods: A cross-sectional study with 37 207 participants (mean age: 36.70 ± 14.79, with 77 % women) was conducted in 38 countries through an online survey administered between April and June 2020. The study utilized a pre-tested food frequency questionnaire to explore food consumption patterns both before and during the COVID-19 periods. Additionally, the study computed Food Consumption Score (FCS) as a proxy indicator for assessing the dietary diversity of households. Findings: This quantification of global, regional and national dietary diversity across 38 countries showed an increment in the consumption of all food groups but a drop in the intake of vegetables and in the dietary diversity. The household's food consumption scores indicating dietary diversity varied across regions. It decreased in the Middle East and North Africa (MENA) countries, including Lebanon (p
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- 2023
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35. Effect of Diltiazem Versus Placebo on Microvascular Dysfunction Assessed By Repeated Continuous Thermodilution Measurements: Results of the EDIT‐CMD Trial
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Tijn P. J. Jansen, Annemiek de Vos, Suzette E. Elias‐Smale, Valeria Paradies, Regina E. Konst, Caïa Crooijmans, Aukelien C. Dimitriu‐Leen, Laura Rodwell, Angela H. E. M. Maas, Pieter C. Smits, Niels van Royen, and Peter Damman
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absolute flow and resistance ,continuous thermodilution ,diltiazem ,microvascular dysfunction ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2023
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36. Perceived barriers, benefits, facilitators, and attitudes of health professionals towards type 2 diabetes management in Oujda, Morocco: a qualitative focus group study
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Usman Sani Dankoly, Dirk Vissers, Souad Ben El Mostafa, Abderrahim Ziyyat, Bart Van Rompaey, Paul Van Royen, and Abdellatif Maamri
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Type 2 diabetes ,Morocco ,Qualitative research ,Health professions ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background In Morocco, the treatment of type 2 diabetes (T2D) is mainly focused on medication and only 2% of patients are coached towards a healthier lifestyle. In Oujda, Eastern Morocco the prevalence of T2D is 10.2%, and the current trend is alarming, especially for women. Therefore, the aim of this study is to explore healthcare professionals (HCP) views on the perceived barriers and benefits of an integrated care approach in primary healthcare centers (PHCCs) to T2D management in Oujda. Methods A qualitative descriptive study using focus groups in 8 PHCCs. This resulted in a sample of 5 doctors and 25 nurses caring for diabetes patients. The transcripts of all conversations were coded to allow for thematic analysis. Results The participants mentioned different barriers to an integrated approach to DM management:: excessive workload; poor reimbursement policy; lack of staff and equipment; interrupted drug supply; poor working environment; limited referral; gap in the knowledge of general practitioners; health beliefs; poverty; advanced age; gender; the use of psychotropic drugs. An integrated approach could be facilitated by simplified electronic records and referrals; uninterrupted free care; staff recruitment; continuous professional development; internships. Benefits: structured care; promotion of care in PHCCs; empowerment of self-management. Conclusion HCP views reflect the urge to strengthen the management of T2D in PHCCs. There is a need for HCP with expertise in physical activity and nutrition to solve the current gap in the multidisciplinary integrated care approach. The specific local context in this Eastern Moroccan region, with limited resources and remote hard-to-reach rural areas, can contribute to patients’ reluctance to change their lifestyles, and is a challenge to provide care in an efficient and sustainable manner. More research is needed to see how a patient-centered multidisciplinary approach to T2D management can help motivate patients in Morocco to change to a healthier lifestyle.
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- 2023
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37. Low levels of monkeypox virus-neutralizing antibodies after MVA-BN vaccination in healthy individuals
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Zaeck, Luca M., Lamers, Mart M., Verstrepen, Babs E., Bestebroer, Theo M., van Royen, Martin E., Götz, Hannelore, Shamier, Marc C., van Leeuwen, Leanne P. M., Schmitz, Katharina S., Alblas, Kimberley, van Efferen, Suzanne, Bogers, Susanne, Scherbeijn, Sandra, Rimmelzwaan, Guus F., van Gorp, Eric C. M., Koopmans, Marion P. G., Haagmans, Bart L., GeurtsvanKessel, Corine H., and de Vries, Rory D.
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- 2023
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38. Think Twice to Be Nice? A User Experience Study on A Reflective Interface to Reduce Cyber Harassment on Social Networking Sites
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Kathleen Van Royen, Karolien Poels, Heidi Vandebosch, and Bieke Zaman
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The use of reflective interfaces has been proposed as a useful strategy to reduce cyber harassment amongst adolescents on social networking sites (SNS). By using machine-learning techniques, harassing online messages can be detected before a user submits it online, whereafter a message prompts the user to reconsider the post. This study builds further upon research focusing on the short-term effectiveness of reflective interfaces in preventing harassment. In this context, though, it is not unlikely that adolescents' user experience with SNS is thwarted when it contains reflective interfaces that might steer their online behaviour. Therefore, this study explores how adolescents evaluate a reflective interface design, in terms of both pragmatic (i.e. functionality, clarity and supportiveness) and hedonic qualities (i.e. autonomy, privacy, self-expression, self-reflection, and pleasure). Moreover, experienced emotions were investigated. In a mixed-method experiment, 24 adolescents (aged 14-16) interacted with a mock SNS with reflective design features. Participants' emotions were observed while interacting on the SNS that prompted a cue (either containing a verbal message or implicit) for each textual harassment attempt. We further investigated the participants' experiences retrospectively while watching the screen capture video of their interaction with the reflective interface, and administered a self-report questionnaire. Findings reveal that adolescents' short-term experiences with SNS in which reflective cues are implemented are not disrupted to a high extent and attitudes are rather positive. Nevertheless, results clearly pointed to a potential fatigue effect in the long-term. Methods to overcome this and alternative options for providing reflective interfaces are suggested.
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- 2022
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39. Transcatheter aortic valve implantation amid the COVID-19 pandemic: a nationwide analysis of the first COVID-19 wave in the Netherlands
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Rooijakkers, M. J. P., Li, W. W. L., Stens, N. A., Vis, M. M., Tonino, P. A. L., Timmers, L., Van Mieghem, N. M., den Heijer, P., Kats, S., Stella, P. R., Roolvink, V., van der Werf, H. W., Stoel, M. G., Schotborgh, C. E., Amoroso, G., Porta, F., van der Kley, F., van Wely, M. H., Gehlmann, H., van Garsse, L. A. F. M., Geuzebroek, G. S. C., Verkroost, M. W. A., Mourisse, J. M., Medendorp, N. M., and van Royen, N.
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- 2022
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40. Continuous Versus Bolus Thermodilution‐Derived Coronary Flow Reserve and Microvascular Resistance Reserve and Their Association With Angina and Quality of Life in Patients With Angina and Nonobstructive Coronaries: A Head‐to‐Head Comparison
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Tijn P. J. Jansen, Annemiek de Vos, Valeria Paradies, Aukelien Dimitriu‐Leen, Caïa Crooijmans, Suzette Elias‐Smale, Laura Rodwell, Angela H. E. M. Maas, Pieter C. Smits, Nico Pijls, Niels van Royen, and Peter Damman
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absolute coronary blood flow ,ANOCA ,coronary function test ,coronary physiology ,microcirculatory resistance ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Coronary flow reserve (CFR) and microvascular resistance reserve (MRR) are physiological parameters to assess coronary microvascular dysfunction. CFR and MRR can be assessed using bolus or continuous thermodilution, and the correlation between these methods has not been clarified. Furthermore, their association with angina and quality of life is unknown. Methods and Results In total, 246 consecutive patients with angina and nonobstructive coronary arteries from the multicenter Netherlands Registry of Invasive Coronary Vasomotor Function Testing (NL‐CFT) were investigated. The 36‐item Short Form Health Survey Quality of Life and Seattle Angina questionnaires were completed by 153 patients before the invasive measurements. CFR and MRR were measured consecutively with bolus and continuous thermodilution. Mean continuous thermodilution‐derived coronary flow reserve (CFRabs) was significantly lower than mean bolus thermodilution‐derived coronary flow reserve (CFRbolus) (2.6±1.0 versus 3.5±1.8; P
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- 2023
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41. Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases
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de Jesus, Adriana A, Hou, Yangfeng, Brooks, Stephen, Malle, Louise, Biancotto, Angelique, Huang, Yan, Calvo, Katherine R, Marrero, Bernadette, Moir, Susan, Oler, Andrew J, Deng, Zuoming, Montealegre Sanchez, Gina A, Ahmed, Amina, Allenspach, Eric, Arabshahi, Bita, Behrens, Edward, Benseler, Susanne, Bezrodnik, Liliana, Bout-Tabaku, Sharon, Brescia, AnneMarie C, Brown, Diane, Burnham, Jon M, Caldirola, Maria Soledad, Carrasco, Ruy, Chan, Alice Y, Cimaz, Rolando, Dancey, Paul, Dare, Jason, DeGuzman, Marietta, Dimitriades, Victoria, Ferguson, Ian, Ferguson, Polly, Finn, Laura, Gattorno, Marco, Grom, Alexei A, Hanson, Eric P, Hashkes, Philip J, Hedrich, Christian M, Herzog, Ronit, Horneff, Gerd, Jerath, Rita, Kessler, Elizabeth, Kim, Hanna, Kingsbury, Daniel J, Laxer, Ronald M, Lee, Pui Y, Lee-Kirsch, Min Ae, Lewandowski, Laura, Li, Suzanne, Lilleby, Vibke, Mammadova, Vafa, Moorthy, Lakshmi N, Nasrullayeva, Gulnara, O'Neil, Kathleen M, Onel, Karen, Ozen, Seza, Pan, Nancy, Pillet, Pascal, Piotto, Daniela Gp, Punaro, Marilynn G, Reiff, Andreas, Reinhardt, Adam, Rider, Lisa G, Rivas-Chacon, Rafael, Ronis, Tova, Rösen-Wolff, Angela, Roth, Johannes, Ruth, Natasha Mckerran, Rygg, Marite, Schmeling, Heinrike, Schulert, Grant, Scott, Christiaan, Seminario, Gisella, Shulman, Andrew, Sivaraman, Vidya, Son, Mary Beth, Stepanovskiy, Yuriy, Stringer, Elizabeth, Taber, Sara, Terreri, Maria Teresa, Tifft, Cynthia, Torgerson, Troy, Tosi, Laura, Van Royen-Kerkhof, Annet, Wampler Muskardin, Theresa, Canna, Scott W, and Goldbach-Mansky, Raphaela
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Genetics ,Clinical Research ,Rare Diseases ,2.1 Biological and endogenous factors ,Aetiology ,Autoimmune Diseases ,Female ,Humans ,Interferon Type I ,Interleukin-18 ,Macrophage Activation Syndrome ,Male ,Mutation ,Panniculitis ,Pulmonary Alveolar Proteinosis ,Genetic diseases ,Immunology ,Inflammation ,Innate immunity ,Monogenic diseases ,Medical and Health Sciences - Abstract
BACKGROUNDUndifferentiated systemic autoinflammatory diseases (USAIDs) present diagnostic and therapeutic challenges. Chronic interferon (IFN) signaling and cytokine dysregulation may identify diseases with available targeted treatments.METHODSSixty-six consecutively referred USAID patients underwent underwent screening for the presence of an interferon signature using a standardized type-I IFN-response-gene score (IRG-S), cytokine profiling, and genetic evaluation by next-generation sequencing.RESULTSThirty-six USAID patients (55%) had elevated IRG-S. Neutrophilic panniculitis (40% vs. 0%), basal ganglia calcifications (46% vs. 0%), interstitial lung disease (47% vs. 5%), and myositis (60% vs. 10%) were more prevalent in patients with elevated IRG-S. Moderate IRG-S elevation and highly elevated serum IL-18 distinguished 8 patients with pulmonary alveolar proteinosis (PAP) and recurrent macrophage activation syndrome (MAS). Among patients with panniculitis and progressive cytopenias, 2 patients were compound heterozygous for potentially novel LRBA mutations, 4 patients harbored potentially novel splice variants in IKBKG (which encodes NF-κB essential modulator [NEMO]), and 6 patients had de novo frameshift mutations in SAMD9L. Of additional 12 patients with elevated IRG-S and CANDLE-, SAVI- or Aicardi-Goutières syndrome-like (AGS-like) phenotypes, 5 patients carried mutations in either SAMHD1, TREX1, PSMB8, or PSMG2. Two patients had anti-MDA5 autoantibody-positive juvenile dermatomyositis, and 7 could not be classified. Patients with LRBA, IKBKG, and SAMD9L mutations showed a pattern of IRG elevation that suggests prominent NF-κB activation different from the canonical interferonopathies CANDLE, SAVI, and AGS.CONCLUSIONSIn patients with elevated IRG-S, we identified characteristic clinical features and 3 additional autoinflammatory diseases: IL-18-mediated PAP and recurrent MAS (IL-18PAP-MAS), NEMO deleted exon 5-autoinflammatory syndrome (NEMO-NDAS), and SAMD9L-associated autoinflammatory disease (SAMD9L-SAAD). The IRG-S expands the diagnostic armamentarium in evaluating USAIDs and points to different pathways regulating IRG expression.TRIAL REGISTRATIONClinicalTrials.gov NCT02974595.FUNDINGThe Intramural Research Program of the NIH, NIAID, NIAMS, and the Clinical Center.
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- 2020
42. Abnormal physiological findings after FFR-based revascularisation deferral are associated with worse prognosis in women
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Masahiro Hoshino, Tim P. van de Hoef, Joo Myung Lee, Rikuta Hamaya, Yoshihisa Kanaji, Coen K. M. Boerhout, Guus A. de Waard, Ji-Hyun Jung, Seung Hun Lee, Hernan Mejia-Renteria, Mauro Echavarria-Pinto, Martijn Meuwissen, Hitoshi Matsuo, Maribel Madera-Cambero, Ashkan Eftekhari, Mohamed A. Effat, Koen Marques, Joon-Hyung Doh, Evald H. Christiansen, Rupak Banerjee, Chang-Wook Nam, Giampaolo Niccoli, Tadashi Murai, Masafumi Nakayama, Nobuhiro Tanaka, Eun-Seok Shin, Tetsuo Sasano, Yolande Appelman, Marcel Beijk, Paul Knaapen, Niels van Royen, Javier Escaned, Bon Kwon Koo, Jan J. Piek, and Tsunekazu Kakuta
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Medicine ,Science - Abstract
Abstract The prognostic value of abnormal resting Pd/Pa and coronary flow reserve (CFR) after fractional flow reserve (FFR)-guided revascularisation deferral according to sex remains unknown. From the ILIAS Registry composed of 20 hospitals globally from 7 countries, patients with deferred lesions following FFR assessment (FFR > 0.8) were included. (NCT 04485234) The primary clinical endpoint was target vessel failure (TVF) at 2-years follow-up. We included 1392 patients with 1759 vessels (n = 564 women, 31.9%). Although resting Pd/Pa was similar between the sexes (p = 0.116), women had lower CFR than men (2.5 [2.0–3.2] vs. 2.7 [2.1–3.5]; p = 0.004). During a 2-year follow-up period, TVF events occurred in 56 vessels (3.2%). The risk of 2-year TVF was significantly higher in women with low versus high resting Pd/Pa (HR: 9.79; p
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- 2023
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43. Motivations for nutrition information-seeking behavior among Belgian adults: a qualitative study
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Jules Vrinten, Kathleen Van Royen, Sara Pabian, Charlotte De Backer, and Christophe Matthys
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Nutrition ,Information-seeking behavior ,Qualitative ,Motivation ,Media ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Nutrition information-seeking behavior is highly prevalent even though it can be challenging to find reliable nutrition information in the current media landscape. Previous quantitative research has identified which population segments use which sources, yet little is known about motivations underpinning nutrition information-seeking behavior. Understanding motivations for seeking nutrition information can increase the efficacy of future nutrition education efforts. The present study aims to identify motivations for nutrition information-seeking behavior among Belgian adults. Methods In-depth qualitative interviews were conducted with 20 adults (n women = 15, n men = 4, n other = 1). Audio-recorded interviews were transcribed verbatim and analyzed in NVivo 12 using inductive thematic analysis. The coding process involved open and axial coding combined with constant comparison to identify themes. Results The interviews revealed a diverse spectrum of motivations for nutrition information-seeking behavior. Five categories of motivations centered on health management, cognitive needs, affective needs, social integrative needs, and personal identity. Participants indicated seeking nutrition information to regain a sense of control over their health and it also helped them express their autonomy. Additionally, participants sought nutrition information out of curiosity or out of a long-standing interest. Nutrition information-seeking was also used as a form of emotion regulation with participants actively engaging in seeking behavior to pursue enjoyment, diversion, confirmation, inspiration, and even relaxation. Furthermore, nutrition information-seeking enabled participants to meet social integrative needs by helping them connect to others, gather social support, help others, and sometimes convince others. Lastly, participants indicated a need for nutrition information to express or defend their identity. Conclusions Our results indicate that beneath the surface of a more apparent need for nutrition information lies a range of motivations demonstrating that nutrition information serves more complex needs than simply information needs. To improve the efficacy of future nutrition education efforts, communication strategies must be tailored to a diverse range of motivations.
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- 2022
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44. Modelling immune cytotoxicity for cholangiocarcinoma with tumour-derived organoids and effector T cells
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Zhou, Guoying, Lieshout, Ruby, van Tienderen, Gilles S., de Ruiter, Valeska, van Royen, Martin E., Boor, Patrick P. C., Magré, Luc, Desai, Jyaysi, Köten, Kübra, Kan, Yik Yang, Ge, Zhouhong, Campos Carrascosa, Lucia, Geuijen, Cecile, Sprengers, Dave, van der Laan, Luc J. W., Verstegen, Monique M. A., and Kwekkeboom, Jaap
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- 2022
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45. Behandeling van persoonlijkheidsstoornissen bij ouderen: drie gevalsbeschrijvingen
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A.C. Videler, R.J.J. van Royen, and S.P.J. van Alphen
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persoonlijkheidsstoornissen ,ouderen ,behandeling ,Medicine - Abstract
Behandeling van persoonlijkheidsstoornissen bij ouderen is een sterk onderbelicht thema. In dit artikel wordt met behulp van drie gevalsbeschrijvingen geïllustreerd dat a) de behandeling van persoonlijkheidsstoornissen bij ouderen zinvol is; b) het onderscheid tussen drie behandelingsniveaus, namelijk persoonlijkheidsveranderende, adaptatiebevorderende en steunend-structurerende behandeling, relevant is in de klinische praktijk; c) op de verschillende behandelingsniveaus rekening gehouden moet worden met gerontologische aspecten, onder andere het toenemend aantal verlieservaringen, hoe ouderen aankijken tegen somatische aandoeningen en de beperkende gevolgen die deze met zich meebrengen, hun veranderend levensperspectief, cohortgebonden en socioculturele overtuigingen, en het belang van intergenerationele relaties. Empirisch onderzoek is nodig naar de generaliseerbaarheid van de bevindingen op basis van de drie gevalsbeschrijvingen.
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- 2023
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46. Quantitative aortography for assessment of aortic regurgitation in the era of percutaneous aortic valve replacement
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Mahmoud Abdelshafy, Patrick W. Serruys, Tsung-Ying Tsai, Pruthvi Chenniganahosahalli Revaiah, Scot Garg, Jean-Paul Aben, Carl J. Schultz, Mohammad Abdelghani, Pim A. L. Tonino, Yosuke Miyazaki, Marcel C. M. Rutten, Martijn Cox, Cherif Sahyoun, Justin Teng, Hiroki Tateishi, Mohamed Abdel-Wahab, Nicolo Piazza, Michele Pighi, Rodrigo Modolo, Martijn van Mourik, Joanna Wykrzykowska, Robbert J. de Winter, Pedro A. Lemos, Fábio S. de Brito, Hideyuki Kawashima, Lars Søndergaard, Liesbeth Rosseel, Rutao Wang, Chao Gao, Ling Tao, Andreas Rück, Won-Keun Kim, Niels van Royen, Christian J. Terkelsen, Henrik Nissen, Matti Adam, Tanja K. Rudolph, Hendrik Wienemann, Ryo Torii, Franz Josef Neuman, Simon Schoechlin, Mao Chen, Ahmed Elkoumy, Hesham Elzomor, Ignacio J. Amat-Santos, Darren Mylotte, Osama Soliman, and Yoshinobu Onuma
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aortic regurgitation ,paravalvular leak ,videodensitometry ,transcatheter aortic valve replacement ,transcatheter aortic valve implantation ,quantitative aortography ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Paravalvular leak (PVL) is a shortcoming that can erode the clinical benefits of transcatheter valve replacement (TAVR) and therefore a readily applicable method (aortography) to quantitate PVL objectively and accurately in the interventional suite is appealing to all operators. The ratio between the areas of the time-density curves in the aorta and left ventricular outflow tract (LVOT-AR) defines the regurgitation fraction (RF). This technique has been validated in a mock circulation; a single injection in diastole was further tested in porcine and ovine models. In the clinical setting, LVOT-AR was compared with trans-thoracic and trans-oesophageal echocardiography and cardiac magnetic resonance imaging. LVOT-AR > 17% discriminates mild from moderate aortic regurgitation on echocardiography and confers a poor prognosis in multiple registries, and justifies balloon post-dilatation. The LVOT-AR differentiates the individual performances of many old and novel devices and is being used in ongoing randomized trials and registries.
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- 2023
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47. Peripheral blood mononuclear cell hyperresponsiveness in patients with premature myocardial infarction without traditional risk factors
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Jan-Quinten Mol, Julia van Tuijl, Siroon Bekkering, Charlotte D.C.C. van der Heijden, Sander A.J. Damen, Benjamin C. Cossins, Liesbeth van Emst, Tim M. Nielen, Laura Rodwell, Yang Li, Gheorghe A.M. Pop, Mihai G. Netea, Niels van Royen, Niels P. Riksen, and Saloua El Messaoudi
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Cardiovascular medicine ,Molecular mechanism of gene regulation ,Components of the immune system ,Transcriptomics ,Science - Abstract
Summary: An increasing number of patients develop an atherothrombotic myocardial infarction (MI) in the absence of standard modifiable risk factors (SMuRFs). Monocytes and macrophages regulate the development of atherosclerosis, and monocytes can adopt a long-term hyperinflammatory phenotype by epigenetic reprogramming, which can contribute to atherogenesis (called “trained immunity”). We assessed circulating monocyte phenotype and function and specific histone marks associated with trained immunity in SMuRFless patients with MI and matched healthy controls. Even in the absence of systemic inflammation, monocytes from SMuRFless patients with MI had an increased overall cytokine production capacity, with the strongest difference for LPS-induced interleukin-10 production, which was associated with an enrichment of the permissive histone marker H3K4me3 at the promoter region. Considering the lack of intervenable risk factors in these patients, trained immunity could be a promising target for future therapy.
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- 2023
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48. Towards individualised treatment of out-of-hospital cardiac arrest patients: an update on technical innovations in the prehospital chain of survival
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Thannhauser, J., Nas, J., Waalewijn, R. A., van Royen, N., Bonnes, J. L., Brouwer, M. A., and de Boer, M. J.
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- 2022
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49. Author Correction: Effect of ticagrelor and prasugrel on remote myocardial inflammation in patients with acute myocardial infarction with ST-elevation: a CMR T1 and T2 mapping study
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Konijnenberg, Lara S. F., Zugwitz, Daša, Everaars, Henk, van der Hoeven, Nina W., Demirkiran, Ahmet, Rodwell, Laura, van Leeuwen, Maarten A. H., van Rossum, Albert C., El Messaoudi, Saloua, Riksen, Niels P., van Royen, Niels, and Nijveldt, Robin
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- 2023
- Full Text
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50. Clinical Events After Deferral of LAD Revascularization Following Physiological Coronary Assessment
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Sen, Sayan, Ahmad, Yousif, Dehbi, Hakim-Moulay, Howard, James P, Iglesias, Juan F, Al-Lamee, Rasha, Petraco, Ricardo, Nijjer, Sukhjinder, Bhindi, Ravinay, Lehman, Sam, Walters, Darren, Sapontis, James, Janssens, Luc, Vrints, Christiaan J, Khashaba, Ahmed, Laine, Mika, Van Belle, Eric, Krackhardt, Florian, Bojara, Waldemar, Going, Olaf, Härle, Tobias, Indolfi, Ciro, Niccoli, Giampaolo, Ribichini, Flavio, Tanaka, Nobuhiro, Yokoi, Hiroyoshi, Takashima, Hiroaki, Kikuta, Yuetsu, Erglis, Andrejs, Vinhas, Hugo, Silva, Pedro Canas, Baptista, Sérgio B, Alghamdi, Ali, Hellig, Farrel, Koo, Bon-Kwon, Nam, Chang-Wook, Shin, Eun-Seok, Doh, Joon-Hyung, Brugaletta, Salvatore, Alegria-Barrero, Eduardo, Meuwissen, Martijin, Piek, Jan J, van Royen, Niels, Sezer, Murat, Di Mario, Carlo, Gerber, Robert T, Malik, Iqbal S, Sharp, Andrew SP, Talwar, Suneel, Tang, Kare, Samady, Habib, Altman, John, Seto, Arnold H, Singh, Jasvindar, Jeremias, Allen, Matsuo, Hitoshi, Kharbanda, Rajesh K, Patel, Manesh R, Serruys, Patrick, Escaned, Javier, and Davies, Justin E
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Biomedical and Clinical Sciences ,Clinical Sciences ,Heart Disease - Coronary Heart Disease ,Heart Disease ,Clinical Research ,Cardiovascular ,Good Health and Well Being ,Aged ,Coronary Angiography ,Coronary Stenosis ,Coronary Vessels ,Female ,Fractional Flow Reserve ,Myocardial ,Humans ,Male ,Middle Aged ,Myocardial Revascularization ,coronary stenosis ,fractional flow reserve ,instantaneous wave-free ratio ,Cardiorespiratory Medicine and Haematology ,Public Health and Health Services ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology - Abstract
BackgroundPhysicians are not always comfortable deferring treatment of a stenosis in the left anterior descending (LAD) artery because of the perception that there is a high risk of major adverse cardiac events (MACE). The authors describe, using the DEFINE-FLAIR (Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularisation) trial, MACE rates when LAD lesions are deferred, guided by physiological assessment using fractional flow reserve (FFR) or the instantaneous wave-free ratio (iFR).ObjectivesThe purpose of this study was to establish the safety of deferring treatment in the LAD using FFR or iFR within the DEFINE-FLAIR trial.MethodsMACE rates at 1 year were compared between groups (iFR and FFR) in patients whose physiological assessment led to LAD lesions being deferred. MACE was defined as a composite of cardiovascular death, myocardial infarction (MI), and unplanned revascularization at 1 year. Patients, and staff performing follow-up, were blinded to whether the decision was made with FFR or iFR. Outcomes were adjusted for age and sex.ResultsA total of 872 patients had lesions deferred in the LAD (421 guided by FFR, 451 guided by iFR). The event rate with iFR was significantly lower than with FFR (2.44% vs. 5.26%; adjusted HR: 0.46; 95% confidence interval [CI]: 0.22 to 0.95; p = 0.04). This was driven by significantly lower unplanned revascularization with iFR and numerically lower MI (unplanned revascularization: 2.22% iFR vs. 4.99% FFR; adjusted HR: 0.44; 95% CI: 0.21 to 0.93; p = 0.03; MI: 0.44% iFR vs. 2.14% FFR; adjusted HR: 0.23; 95% CI: 0.05 to 1.07; p = 0.06).ConclusionsiFR-guided deferral appears to be safe for patients with LAD lesions. Patients in whom iFR-guided deferral was performed had statistically significantly lower event rates than those with FFR-guided deferral.
- Published
- 2019
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