Search

Your search keyword '"Van Rompaey P"' showing total 342 results
Start Over Author "Van Rompaey P"
342 results on '"Van Rompaey P"'

2. Holistic assessment of cochlear implant outcomes using the international classification of functioning disability and health model: data analysis of a longitudinal prospective multicenter study

Author

Andries, Ellen, Lorens, Artur, Skarżyński, Piotr Henryk, Skarżyński, Henryk, Calvino, Miryam, Gavilán, Javier, Lassaletta, Luis, Tavora-Vieira, Dayse, Acharya, Aanand, Kurz, Anja, Hagen, Rudolf, Anderson, Ilona, Koinig, Karin, Abdelsamad, Yassin, Van de Heyning, Paul, Van Rompaey, Vincent, and Mertens, Griet

Published
2024
Full Text
View/download PDF

6. Cross-sectional evaluation of pharmaceutical care competences in nurse education: how well do curricula prepare students of different educational levels?

Author

De Baetselier, Elyne, Dijkstra, Nienke E., Batalha, Luis M., Carvalho Ferreira, Paulo A., Filov, Izabela, Grøndahl, Vigdis A., Heczkova, Jana, Helgesen, Ann K., Jordan, Sue, Karnjuš, Igor, Kolovos, Petros, Langer, Gero, Lillo-Crespo, Manuel, Malara, Alba, Padyšaková, Hana, Prosen, Mirko, Pusztai, Dorina, Raposa, Bence, Riquelme-Galindo, Jorge, Rottková, Jana, Sino, Carolien G. M., Talarico, Francesco, Tingle, Nicola, Tziaferi, Styliani, Van Rompaey, Bart, and Dilles, Tinne

Published
2024
Full Text
View/download PDF

22. Discrimination and Calibration of the Veterans Aging Cohort Study Index 2.0 for Predicting Mortality Among People With Human Immunodeficiency Virus in North America

Author

McGinnis, Kathleen A, Justice, Amy C, Moore, Richard D, Silverberg, Michael J, Althoff, Keri N, Karris, Maile, Lima, Viviane D, Crane, Heidi M, Horberg, Michael A, Klein, Marina B, Gange, Stephen J, Gebo, Kelly A, Mayor, Angel, Tate, Janet P, Benson, Constance A, Bosch, Ronald J, Kirk, Gregory D, Marconi, Vincent, Colasanti, Jonathan, Mayer, Kenneth H, Grasso, Chris, Hogg, Robert S, Montaner, Julio SG, Sereda, Paul, Salters, Kate, Buchacz, Kate, Li, Jun, Jacobson, Jeffrey M, Thorne, Jennifer E, Brown, Todd, Tien, Phyllis, D’Souza, Gypsyamber, Smith, Graham, Loutfy, Mona, Gupta, Meenakshi, Rabkin, Charles, Kroch, Abigail, Burchell, Ann, Betts, Adrian, Lindsay, Joanne, Nijhawan, Ank, Mayor, Angel M, Gill, M John, Martin, Jeffrey N, Brooks, John T, Saag, Michael S, Mugavero, Michael J, Willig, James, Bamford, Laura, Eron, Joseph J, Napravnik, Sonia, Kitahata, Mari M, Sterling, Timothy R, Haas, David, Rebeiro, Peter, Turner, Megan, Lee, Jennifer S, McKaig, Rosemary G, Freeman, Aimee M, Van Rompaey, Stephen E, Morton, Liz, McReynolds, Justin, Lober, William B, Hogan, Brenna, You, Bin, Humes, Elizabeth, Gerace, Lucas, Stewart, Cameron, and Coburn, Sally

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Aging, Women's Health, Infectious Diseases, Sexually Transmitted Infections, HIV/AIDS, 2.4 Surveillance and distribution, Infection, Good Health and Well Being, Calibration, Cohort Studies, Female, HIV, HIV Infections, Humans, Male, Middle Aged, North America, Veterans, VACS Index 2.0, calibration, mortality, North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD)a of the International Epidemiologic Databases to Evaluate AIDS (IeDEA) and Veterans Aging Cohort Study, Biological Sciences, Medical and Health Sciences, Microbiology, Clinical sciences
Abstract

BackgroundThe updated Veterans Aging Cohort Study (VACS) Index 2.0 combines general and human immunodeficiency virus (HIV)-specific biomarkers to generate a continuous score that accurately discriminates risk of mortality in diverse cohorts of persons with HIV (PWH), but a score alone is difficult to interpret. Using data from the North American AIDS Cohort Collaboration (NA-ACCORD), we translate VACS Index 2.0 scores into validated probability estimates of mortality.MethodsBecause complete mortality ascertainment is essential for accurate calibration, we restricted analyses to cohorts with mortality from the National Death Index or equivalent sources. VACS Index 2.0 components were ascertained from October 1999 to April 2018. Mortality was observed up to March 2019. Calibration curves compared predicted (estimated by fitting a gamma model to the score) to observed mortality overall and within subgroups: cohort (VACS/NA-ACCORD subset), sex, age 500 copies/mL, CD4 count

Published
2022

23. Factors Associated With Severity of COVID-19 Disease in a Multicenter Cohort of People With HIV in the United States, March–December 2020

Author

Shapiro, Adrienne E, Ignacio, Rachel A Bender, Whitney, Bridget M, Delaney, Joseph A, Nance, Robin M, Bamford, Laura, Wooten, Darcy, Keruly, Jeanne C, Burkholder, Greer, Napravnik, Sonia, Mayer, Kenneth H, Webel, Allison R, Kim, H Nina, Van Rompaey, Stephen E, Christopoulos, Katerina, Jacobson, Jeffrey, Karris, Maile, Smith, Davey, Johnson, Mallory O, Willig, Amanda, Eron, Joseph J, Hunt, Peter, Moore, Richard D, Saag, Michael S, Mathews, W Christopher, Crane, Heidi M, Cachay, Edward R, Kitahata, Mari M, and Systems, for the CFAR Network of Integrated Clinical

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Emerging Infectious Diseases, Clinical Research, Infectious Diseases, Lung, Prevention, Sexually Transmitted Infections, Coronaviruses, HIV/AIDS, Infection, Good Health and Well Being, CD4 Lymphocyte Count, COVID-19, COVID-19 Vaccines, HIV Infections, Humans, Renal Insufficiency, Chronic, United States, HIV, CD4 count, structural determinants of health, immunosuppression, CFAR Network of Integrated Clinical Systems, Public Health and Health Services, Virology, Clinical sciences, Epidemiology, Public health
Abstract

BackgroundUnderstanding the spectrum of COVID-19 in people with HIV (PWH) is critical to provide clinical guidance and risk reduction strategies.SettingCenters for AIDS Research Network of Integrated Clinic System, a US multisite clinical cohort of PWH in care.MethodsWe identified COVID-19 cases and severity (hospitalization, intensive care, and death) in a large, diverse HIV cohort during March 1, 2020-December 31, 2020. We determined predictors and relative risks of hospitalization among PWH with COVID-19, adjusted for disease risk scores.ResultsOf 16,056 PWH in care, 649 were diagnosed with COVID-19 between March and December 2020. Case fatality was 2%; 106 (16.3%) were hospitalized, and 12 died. PWH with current CD4 count

Published
2022

24. GEVD-based Low-Rank Channel Covariance Matrix Estimation and MMSE Channel Estimation for Uplink Cellular Massive MIMO Systems

Author

Van Rompaey, Robbe and Moonen, Marc

Subjects
Electrical Engineering and Systems Science - Signal Processing
Abstract

Uplink channel estimation is a crucial component for the performance of cellular massive MIMO systems. However, when the number of user equipments (UEs) grows, the sharing of the available resources causes interference between UEs in neighboring cells. Minimum mean squared error (MMSE) channel estimators have been proposed to mitigate this interference, but these require estimates of the channel covariance matrices. Therefore, a new channel covariance matrix estimator for low-rank channel covariance matrices is presented in this paper, using a generalized eigenvalue decomposition (GEVD) of two covariance matrices that can be estimated from the available uplink data. The requirements for the systems are minimal and, except for synchronization, there is no need for communication between the different cells and no prior knowledge on the background noise is required. Approximate MMSE estimators are also derived based on the newly proposed channel covariance matrix estimator. The effectiveness of the proposed methods is demonstrated in numerical simulations.

Published
2021

26. On the long-term learning ability of LSTM LMs

Author

Boes, Wim, Van Rompaey, Robbe, Verwimp, Lyan, Pelemans, Joris, Van hamme, Hugo, and Wambacq, Patrick

Subjects
Computer Science - Computation and Language, Computer Science - Machine Learning
Abstract

We inspect the long-term learning ability of Long Short-Term Memory language models (LSTM LMs) by evaluating a contextual extension based on the Continuous Bag-of-Words (CBOW) model for both sentence- and discourse-level LSTM LMs and by analyzing its performance. We evaluate on text and speech. Sentence-level models using the long-term contextual module perform comparably to vanilla discourse-level LSTM LMs. On the other hand, the extension does not provide gains for discourse-level models. These findings indicate that discourse-level LSTM LMs already rely on contextual information to perform long-term learning.

Published
2021

31. CD4 Count at Entry into Care and at Antiretroviral Therapy Prescription among Adults with Human Immunodeficiency Virus in the United States, 2005-2018

Author

Lee, Jennifer S, Humes, Elizabeth A, Hogan, Brenna C, Buchacz, Kate, Eron, Joseph J, Gill, M John, Sterling, Timothy R, Rebeiro, Peter F, Lima, Viviane Dias, Mayor, Angel, Silverberg, Michael J, Horberg, Michael A, Moore, Richard D, Althoff, Keri N, Benson, Constance A, Bosch, Ronald J, Emory-Grady, Gregory D Kirk, Mayer, Kenneth H, Grasso, Chris, Hogg, Robert S, Harrigan, P Richard, Montaner, Julio SG, Yip, Benita, Zhu, Julia, Salters, Kate, Gabler, Karyn, Li, Jun, Gebo, Kelly A, Johns, Richard D Moore, Carey, John T, Rodriguez, Benigno, Thorne, Jennifer E, Brown, Todd, Tien, Phyllis, D’Souza, Gypsyamber, Crouzat, Frederic, Loutfy, Mona, Smith, Graham, Gupta, Meenakshi, Klein, Marina B, Rabkin, Charles, Kroch, Abigail, Burchell, Ann, Betts, Adrian, Lindsay, Joanne, Nijhawan, Ank, Hunter-Mellado, Robert F, Mayor, Angel M, Martin, Jeffrey N, Brooks, John T, Saag, Michael S, Mugavero, Michael J, Willig, James, Bamford, Laura, Karris, Maile, Napravnik, Sonia, Kitahata, Mari M, Crane, Heidi M, Haas, David, Rebeiro, Peter, Turner, Megan, Park, Lesley, Justice, Amy, Gange, Stephen J, McKaig, Rosemary G, Freeman, Aimee M, Van Rompaey, Stephen E, Morton, Liz, McReynolds, Justin, Lober, William B, Hogan, Brenna, You, Bin, Humes, Elizabeth, Gerace, Lucas, Stewart, Cameron, and Coburn, Sally

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Infection, Adult, Anti-HIV Agents, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, HIV, HIV Infections, Humans, Prescriptions, United States, North American AIDS Cohort Collaboration on Research and Design, CD4 count, antiretroviral therapy, treat all, universal treatment, Biological Sciences, Medical and Health Sciences, Microbiology, Clinical sciences
Abstract

From 2005 to 2018, among 32013 adults with human immunodeficiency virus entering care, median time to antiretroviral therapy (ART) prescription declined from 69 to 6 days, CD4 count at entry into care increased from 300 to 362 cells/μL, and CD4 count at ART prescription increased from 160 to 364 cells/μL.

Published
2021

32. Current and Past Immunodeficiency Are Associated With Higher Hospitalization Rates Among Persons on Virologically Suppressive Antiretroviral Therapy for up to 11 Years

Author

Davy-Mendez, Thibaut, Napravnik, Sonia, Eron, Joseph J, Cole, Stephen R, van Duin, David, Wohl, David A, Hogan, Brenna C, Althoff, Keri N, Gebo, Kelly A, Moore, Richard D, Silverberg, Michael J, Horberg, Michael A, Gill, M John, Mathews, W Christopher, Klein, Marina B, Colasanti, Jonathan A, Sterling, Timothy R, Mayor, Angel M, Rebeiro, Peter F, Buchacz, Kate, Li, Jun, Nanditha, Ni Gusti Ayu, Thorne, Jennifer E, Nijhawan, Ank, Berry, Stephen A, Benson, Constance A, Bosch, Ronald J, Kirk, Gregory D, Mayer, Kenneth H, Grasso, Chris, Hogg, Robert S, Montaner, Julio SG, Salters, Kate, Lima, Viviane D, Sereda, Paul, Trigg, Jason, Rodriguez, Benigno, Brown, Todd, Tien, Phyllis, D’Souza, Gypsyamber, Rabkin, Charles, Kroch, Abigail, Burchell, Ann, Betts, Adrian, Lindsay, oanne, Hunter-Mellado, Robert F, Martin, Jeffrey N, Brooks, John T, Saag, Michael S, Mugavero, Michael J, Willig, James, Mathews, William C, Kitahata, Mari M, Crane, Heidi M, Haas, David, Rebeiro, Peter, Turner, Megan, Tate, Janet, Dubrow, Robert, Fiellin, David, Gange, Stephen J, McKaig, Rosemary G, Freeman, Aimee M, Van Rompaey, Stephen E, Morton, Liz, McReynolds, Justin, Lober, William B, Lee, Jennifer S, You, Bin, Hogan, Brenna, Zhang, Jinbing, and Jing, Jerry

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Infectious Diseases, Sexually Transmitted Infections, Anti-HIV Agents, CD4 Lymphocyte Count, Canada, Cohort Studies, Female, HIV Infections, Hospitalization, Humans, Male, Viral Load, HIV/AIDS, 6.1 Pharmaceuticals, HIV, hospitalization, CD4 lymphocyte count, sustained virologic response, cohort studies, North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of IeDEA, Biological Sciences, Medical and Health Sciences, Microbiology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundPersons with HIV (PWH) with persistently low CD4 counts despite efficacious antiretroviral therapy could have higher hospitalization risk.MethodsIn six US and Canadian clinical cohorts, PWH with virologic suppression for ≥1 year in 2005-2015 were followed until virologic failure, loss to follow-up, death, or study end. Stratified by early (Years 2-5) and long-term (Years 6-11) suppression and lowest pre-suppression CD4 count 500 cells/μL had an aIRR of 1.44 during early suppression (95% CI 1.01-2.06), and 1.67 (1.03-2.72) during long-term suppression. Among patients with lowest pre-suppression CD4 ≥200 (56%), patients with current CD4 351-500 versus >500 cells/μL had an aIRR of 1.22 (0.93-1.60) during early suppression and 2.09 (1.18-3.70) during long-term suppression.ConclusionsVirologically suppressed patients with lower CD4 counts experienced higher hospitalization rates, and could potentially benefit from targeted clinical management strategies.

Published
2021

33. Hospitalization Rates and Causes Among Persons With HIV in the United States and Canada, 2005–2015

Author

Davy-Mendez, Thibaut, Napravnik, Sonia, Hogan, Brenna C, Althoff, Keri N, Gebo, Kelly A, Moore, Richard D, Horberg, Michael A, Silverberg, Michael J, Gill, M John, Crane, Heidi M, Marconi, Vincent C, Bosch, Ronald J, Colasanti, Jonathan A, Sterling, Timothy R, Mathews, W Christopher, Mayor, Angel M, Nanditha, Ni Gusti Ayu, Buchacz, Kate, Li, Jun, Rebeiro, Peter F, Thorne, Jennifer E, Nijhawan, Ank, van Duin, David, Wohl, David A, Eron, Joseph J, Berry, Stephen A, Benson, Constance A, Kirk, Gregory D, Mayer, Kenneth H, Grasso, Chris, Hogg, Robert S, Harrigan, P Richard, Montaner, Julio SG, Yip, Benita, Zhu, Julia, Salters, Kate, Gabler, Karyn, Carey, John T, Rodriguez, Benigno, Brown, Todd, Tien, Phyllis, D’Souza, Gypsyamber, Rabkin, Charles, Klein, Marina B, Kroch, Abigail, Burchell, Ann, Betts, Adrian, Lindsay, Joanne, Hunter-Mellado, Robert F, Martin, Jeffrey N, Brooks, John T, Saag, Michael S, Mugavero, Michael J, Willig, James, Mathews, William C, Kitahata, Mari M, Haas, David, Rebeiro, Peter, Turner, Megan, Tate, Janet, Dubrow, Robert, Fiellin, David, Gange, Stephen J, McKaig, Rosemary G, Freeman, Aimee M, Van Rompaey, Stephen E, Morton, Liz, McReynolds, Justin, Lober, William B, Lee, Jennifer S, and You, Bin

Subjects
Biomedical and Clinical Sciences, Public Health, Health Sciences, Clinical Sciences, Medical Microbiology, Infectious Diseases, HIV/AIDS, Prevention, Sexually Transmitted Infections, Aging, Infection, Good Health and Well Being, Acquired Immunodeficiency Syndrome, Anti-HIV Agents, CD4 Lymphocyte Count, Canada, Comorbidity, HIV Infections, Hospitalization, Humans, Risk Factors, United States, Viral Load, HIV, hospitalization, cohort studies, North American AIDS Cohort Collaboration on Research and Design of IeDEA, Biological Sciences, Medical and Health Sciences, Microbiology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundTo assess the possible impact of antiretroviral therapy improvements, aging, and comorbidities, we examined trends in all-cause and cause-specific hospitalization rates among persons with HIV (PWH) from 2005 to 2015.MethodsIn 6 clinical cohorts, we followed PWH in care (≥1 outpatient CD4 count or HIV load [VL] every 12 months) and categorized ICD codes of primary discharge diagnoses using modified Clinical Classifications Software. Poisson regression estimated hospitalization rate ratios for calendar time trends, adjusted for demographics, HIV risk factor, and annually updated age, CD4, and VL.ResultsAmong 28 057 patients (125 724 person-years), from 2005 to 2015, the median CD4 increased from 389 to 580 cells/µL and virologic suppression from 55% to 85% of patients. Unadjusted all-cause hospitalization rates decreased from 22.3 per 100 person-years in 2005 (95% confidence interval [CI], 20.6-24.1) to 13.0 in 2015 (95% CI, 12.2-14.0). Unadjusted rates decreased for almost all diagnostic categories. Adjusted rates decreased for all-cause, cardiovascular, and AIDS-defining conditions, increased for non-AIDS-defining infection, and were stable for most other categories.ConclusionsAmong PWH with increasing CD4 counts and viral suppression, unadjusted hospitalization rates decreased for all-cause and most cause-specific hospitalizations, despite the potential effects of aging, comorbidities, and cumulative exposure to HIV and antiretrovirals.

Published
2021

35. Association of Immunosuppression and Human Immunodeficiency Virus (HIV) Viremia With Anal Cancer Risk in Persons Living With HIV in the United States and Canada

Author

Hernández-Ramírez, Raúl U, Qin, Li, Lin, Haiqun, Leyden, Wendy, Neugebauer, Romain S, Althoff, Keri N, Hessol, Nancy A, Achenbach, Chad J, Brooks, John T, Gill, M John, Grover, Surbhi, Horberg, Michael A, Li, Jun, Mathews, W Christopher, Mayor, Angel M, Patel, Pragna, Rabkin, Charles S, Rachlis, Anita, Justice, Amy C, Moore, Richard D, Engels, Eric A, Silverberg, Michael J, Dubrow, Robert, Benson, Constance A, Bosch, Ronald J, Kirk, Gregory D, Mayer, Kenneth H, Grasso, Chris, Hogg, Robert S, Harrigan, P Richard, Montaner, Julio SG, Yip, Benita, Zhu, Julia, Salters, Kate, Gabler, Karyn, Buchacz, Kate, Gebo, Kelly A, Rodriguez, Benigno, Thorne, Jennifer E, Rabkin, Charles, Margolick, Joseph B, Jacobson, Lisa P, D’Souza, Gypsyamber, Klein, Marina B, Kroch, Abigail, Burchell, Ann, Betts, Adrian, Lindsay, Joanne, Hunter-Mellado, Robert F, Deeks, Steven G, Martin, Jeffrey N, Saag, Michael S, Mugavero, Michael J, Willig, James, Mathews, William C, Eron, Joseph J, Napravnik, Sonia, Kitahata, Mari M, Crane, Heidi M, Drozd, Daniel R, Sterling, Timothy R, Haas, David, Rebeiro, Peter, Turner, Megan, Fiellin, David, Gange, Stephen J, Anastos, Kathryn, McKaig, Rosemary G, Freeman, Aimee M, Van Rompaey, Stephen E, Morton, Liz, McReynolds, Justin, Lober, William B, Lee, Jennifer S, and You, Bin

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, HIV/AIDS, Digestive Diseases, Prevention, Infectious Diseases, Sexually Transmitted Infections, Cancer, Clinical Research, Infection, Good Health and Well Being, Anus Neoplasms, CD4 Lymphocyte Count, Canada, HIV, HIV Infections, Humans, Immunosuppression Therapy, United States, Viral Load, Viremia, HIV infection, CD4+T-cell count, HIV-1 RNA viral load, anal cancer, risk, North American AIDS Cohort Collaboration on Research and Design of the International Epidemiologic Databases to Evaluate AIDS, CD4+ T-cell count, Biological Sciences, Medical and Health Sciences, Microbiology, Clinical sciences
Abstract

BackgroundPeople living with human immunodeficiency virus (HIV; PLWH) have a markedly elevated anal cancer risk, largely due to loss of immunoregulatory control of oncogenic human papillomavirus infection. To better understand anal cancer development and prevention, we determined whether recent, past, cumulative, or nadir/peak CD4+ T-cell count (CD4) and/or HIV-1 RNA level (HIV RNA) best predict anal cancer risk.MethodsWe studied 102 777 PLWH during 1996-2014 from 21 cohorts participating in the North American AIDS Cohort Collaboration on Research and Design. Using demographics-adjusted, cohort-stratified Cox models, we assessed associations between anal cancer risk and various time-updated CD4 and HIV RNA measures, including cumulative and nadir/peak measures during prespecified moving time windows. We compared models using the Akaike information criterion.ResultsCumulative and nadir/peak CD4 or HIV RNA measures from approximately 8.5 to 4.5 years in the past were generally better predictors for anal cancer risk than their corresponding more recent measures. However, the best model included CD4 nadir (ie, the lowest CD4) from approximately 8.5 years to 6 months in the past (hazard ratio [HR] for

Published
2020

42. Mind the gap: observation windows to define periods of event ascertainment as a quality control method for longitudinal electronic health record data

Author

Althoff, Keri N, Wong, Cherise, Hogan, Brenna, Desir, Fidel, You, Bin, Humes, Elizabeth, Zhang, Jinbing, Jing, Yuezhou, Modur, Sharada, Lee, Jennifer S, Freeman, Aimee, Kitahata, Mari, Van Rompaey, Stephen, Mathews, W Christopher, Horberg, Michael A, Silverberg, Michael J, Mayor, Angel M, Salters, Kate, Moore, Richard D, Gange, Stephen J, and Research and Design, North American AIDS Cohort Collaboration on

Subjects
Epidemiology, Health Services and Systems, Health Sciences, Diabetes, Clinical Research, Diabetes Mellitus, Type 2, Electronic Health Records, HIV Infections, Humans, Incidence, Quality Control, Electronic medical records, Health research, HIV, Immortal person-time, Quality control, North American AIDS Cohort Collaboration on Research and Design, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences
Abstract

PurposeUse of electronic health records (EHRs) in health research may lead to the false assumption of complete event ascertainment. We estimated "observation windows" (OWs), defined as periods within which the assumption of complete ascertainment of events is more likely to hold, as a quality control approach to reducing the likelihood of this false assumption. We demonstrated the impact of OWs on estimating the rates of type II diabetes mellitus (diabetes) from HIV clinical cohorts.MethodsData contributed by 16 HIV clinical cohorts to the NA-ACCORD were used to identify and evaluate OWs for an operationalized definition of diabetes occurrence as a case study. Procedures included (1) gathering cohort-level data; (2) visualizing and summarizing gaps in observations; (3) systematically establishing start and stop dates during which the assumption of complete ascertainment of diabetes events was reasonable; and (4) visualizing the diabetes OWs relative to the cohort open and close dates to identify immortal person-time. We estimated diabetes occurrence event rates and 95% confidence intervals in the most recent decade that data were available (January 1, 2007, to December 31, 2016).ResultsThe number of diabetes events decreased by 17% with the use of the diabetes OWs; immortal person-time was removed decreasing total person-years by 23%. Consequently, the diabetes rate increased from 1.23 (95% confidence interval [1.20, 1.25]) per 100 person-years to 1.32 [1.29, 1.35] per 100 person-years with the use of diabetes OWs.ConclusionsAs the use of EHR-curated data for event-driven health research continues to expand, OWs have utility as a quality control approach to complete event ascertainment, helping to improve accuracy of estimates by removing immortal person-time when ascertainment is incomplete.

Published
2019

43. Association of immunosuppression and HIV viraemia with non-Hodgkin lymphoma risk overall and by subtype in people living with HIV in Canada and the USA: a multicentre cohort study

Author

Hernández-Ramírez, Raúl U, Qin, Li, Lin, Haiqun, Leyden, Wendy, Neugebauer, Romain S, Althoff, Keri N, Achenbach, Chad J, Hessol, Nancy A, D'Souza, Gypsyamber, Gebo, Kelly A, Gill, M John, Grover, Surbhi, Horberg, Michael A, Li, Jun, Mathews, W Christopher, Mayor, Angel M, Park, Lesley S, Rabkin, Charles S, Salters, Kate, Justice, Amy C, Moore, Richard D, Engels, Eric A, Silverberg, Michael J, Dubrow, Robert, AIDS, North American AIDS Cohort Collaboration on Research and Design of the International Epidemiologic Databases to Evaluate, Betts, Adrian, Brooks, John T, Freeman, Aimee M, Van Rompaey, Stephen E, Burchell, Ann, Yip, Benita, You, Bin, Hogan, Brenna, Grasso, Chris, Hogg, Robert S, Benson, Constance A, Drozd, Daniel R, Sterling, Timothy R, Haas, David, Humes, Elizabeth, Crane, Heidi M, Willig, James, Eron, Joseph J, Martin, Jeffrey N, Saag, Michael S, Jing, Jerry, Zhang, Jinbing, Lindsay, Joanne, Hunter-Mellado, Robert F, Deeks, Steven G, Zhu, Julia, Montaner, Julio SG, McReynolds, Justin, Gabler, Karyn, Buchacz, Kate, Rodriguez, Benigno, Thorne, Jennifer E, Margolick, Joseph B, Anastos, Kathryn, Jacobson, Lisa P, Klein, Marina B, Kroch, Abigail, Morton, Liz, Turner, Megan, Fiellin, David, Gange, Stephen J, Mugavero, Michael J, Harrigan, P Richard, Rebeiro, Peter, Bosch, Ronald J, Kirk, Gregory D, Mayer, Kenneth H, McKaig, Rosemary G, Coburn, Sally, Napravnik, Sonia, Kitahata, Mari M, Lober, William B, and Lee, Jennifer S

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Oncology and Carcinogenesis, Cancer, Prevention, Lymphoma, Rare Diseases, Sexually Transmitted Infections, Hematology, Lymphatic Research, Infectious Diseases, HIV/AIDS, 2.1 Biological and endogenous factors, Infection, Good Health and Well Being, Adolescent, Adult, Aged, Aged, 80 and over, CD4 Lymphocyte Count, Canada, Cohort Studies, Female, HIV Infections, Humans, Immune Tolerance, Lymphoma, Non-Hodgkin, Male, Middle Aged, Risk Assessment, United States, Viral Load, Young Adult, North American AIDS Cohort Collaboration on Research and Design of the International Epidemiologic Databases to Evaluate AIDS, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundResearch is needed to better understand relations between immunosuppression and HIV viraemia and risk for non-Hodgkin lymphoma, a common cancer in people living with HIV. We aimed to identify key CD4 count and HIV RNA (viral load) predictors of risk for non-Hodgkin lymphoma, overall and by subtype.MethodsWe studied people living with HIV during 1996-2014 from 21 Canadian and US cohorts participating in the North American AIDS Cohort Collaboration on Research and Design. To determine key independent predictors of risk for non-Hodgkin lymphoma, we assessed associations with time-updated recent, past, cumulative, and nadir or peak measures of CD4 count and viral load, using demographics-adjusted, cohort-stratified Cox models, and we compared models using Akaike's information criterion.FindingsOf 102 131 people living with HIV during the study period, 712 people developed non-Hodgkin lymphoma. The key independent predictors of risk for overall non-Hodgkin lymphoma were recent CD4 count (ie, lagged by 6 months;

Published
2019

44. One Size Fits (n)One: The Influence of Sex, Age, and Sexual Human Immunodeficiency Virus (HIV) Acquisition Risk on Racial/Ethnic Disparities in the HIV Care Continuum in the United States

Author

Desir, Fidel A, Lesko, Catherine R, Moore, Richard D, Horberg, Michael A, Wong, Cherise, Crane, Heidi M, Silverberg, Michael, Thorne, Jennifer E, Rachlis, Beth, Rabkin, Charles, Mayor, Angel M, Mathews, William C, Althoff, Keri N, Benson, Constance A, Bosch, Ronald J, Fenway, Gregory D Kirk, Boswell, Stephen, Mayer, Kenneth H, Grasso, Chris, Hogg, Robert S, Harrigan, P Richard, Montaner, Julio SG, Yip, Benita, Zhu, Julia, Salters, Kate, Gabler, Karyn, Buchacz, Kate, Brooks, John T, Gebo, Kelly A, Carey, John T, Rodriguez, Benigno, Silverberg, Michael J, Margolick, Joseph B, Jacobson, Lisa P, D’Souza, Gypsyamber, Klein, Marina B, Kroch, Abigail, Burchell, Ann, Rachlis, Anita, Cupido, Patrick, Lindsay, Joanne, Hunter-Mellado, Robert F, Gill, M John, Deeks, Steven G, Martin, Jeffrey N, Patel, Pragna, Saag, Michael S, Mugavero, Michael J, Willig, James, Eron, Joseph J, Napravnik, Sonia, Kitahata, Mari M, Drozd, Daniel R, Sterling, Timothy R, Haas, David, Rebeiro, Peter, Turner, Megan, Bebawy, Sally, Rogers, Ben, Justice, Amy C, Dubrow, Robert, Fiellin, David, Gange, Stephen J, Anastos, Kathryn, McKaig, Rosemary G, Freeman, Aimee M, Lent, Carol, Van Rompaey, Stephen E, Morton, Liz, McReynolds, Justin, Lober, William B, Lee, Jennifer S, You, Bin, Hogan, Brenna, Zhang, Jinbing, and Jing, Jerry

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Health Disparities, Sexually Transmitted Infections, Minority Health, Sexual and Gender Minorities (SGM/LGBT*), HIV/AIDS, Behavioral and Social Science, Infectious Diseases, Clinical Research, Infection, Good Health and Well Being, Adolescent, Adult, Cohort Studies, Continuity of Patient Care, Ethnicity, Female, HIV Infections, Homosexuality, Male, Humans, Male, Middle Aged, Racial Groups, Risk Factors, Sexual Behavior, United States, Viral Load, Young Adult, HIV care continuum, racial/ethnic disparities, key populations, North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) Region of the International Epidemiologic Databases to Evaluate AIDS (IeDEA) Consortium, Biological Sciences, Medical and Health Sciences, Microbiology, Clinical sciences
Abstract

BackgroundThe United States National HIV/AIDS Strategy established goals to reduce disparities in retention in human immunodeficiency virus (HIV) care, antiretroviral therapy (ART) use, and viral suppression. The impact of sex, age, and sexual HIV acquisition risk (ie, heterosexual vs same-sex contact) on the magnitude of HIV-related racial/ethnic disparities is not well understood.MethodsWe estimated age-stratified racial/ethnic differences in the 5-year restricted mean percentage of person-time spent in care, on ART, and virally suppressed among 19 521 women (21.4%), men who have sex with men (MSM; 59.0%), and men who have sex with women (MSW; 19.6%) entering HIV care in the North American AIDS Cohort Collaboration on Research and Design between 2004 and 2014.ResultsAmong women aged 18-29 years, whites spent 12.0% (95% confidence interval [CI], 1.1%-20.2%), 9.2% (95% CI, .4%-20.4%), and 13.5% (95% CI, 2.7%-22.5%) less person-time in care, on ART, and virally suppressed, respectively, than Hispanics. Black MSM aged ≥50 years spent 6.3% (95% CI, 1.3%-11.7%), 11.0% (95% CI, 4.6%-18.1%), and 9.7% (95% CI, 3.6%-16.8%) less person-time in these stages, respectively, than white MSM ≥50 years of age. Among MSM aged 40-49 years, blacks spent 9.8% (95% CI, 2.4%-16.5%) and 11.9% (95% CI, 3.8%-19.3%) less person-time on ART and virally suppressed, respectively, than whites.ConclusionsRacial/ethnic differences in HIV care persist in specific populations defined by sex, age, and sexual HIV acquisition risk. Clinical and public health interventions that jointly target these demographic factors are needed.

Published
2019

47. Diagnostic accuracy and usability of the EMBalance decision support system for vestibular disorders in primary care: proof of concept randomised controlled study results

Author

Bamiou, Doris-Eva, Kikidis, Dimitris, Bibas, Thanos, Koohi, Nehzat, Macdonald, Nora, Maurer, Christoph, Wuyts, Floris L., Ihtijarevic, Berina, Celis, Laura, Mucci, Viviana, Maes, Leen, Van Rompaey, Vincent, Van de Heyning, Paul, Nazareth, Irwin, Exarchos, Themis P., Fotiadis, Dimitrios, Koutsouris, Dimitrios, and Luxon, Linda M.

Published
2022
Full Text
View/download PDF

48. The Correlation Between Fear Avoidance Beliefs and Physical Activity in Unilateral Vestibulopathies.

Author

Van Laer, Lien, Koppelaar-van Eijsden, Hanna M., Hallemans, Ann, Van Rompaey, Vincent, Schermer, Tjard R., Bruintjes, Tjasse D., and Vereeck, Luc

Abstract

Background and Purpose: In individuals with unilateral vestibulopathy (UVP), physical activity (PA) is recommended to stimulate central vestibular compensation. However, the presence of fear avoidance beliefs might negatively influence PA. The objectives of this study were to investigate the relationship between fear avoidance beliefs and PA and to compare PA levels between individuals with UVP in an acute/subacute vs chronic phase. Methods: In this cross-sectional study, PA was measured using a triaxial accelerometer. Fear avoidance beliefs were quantified using the Vestibular Activities Avoidance Instrument. The correlation between fear avoidance beliefs and PA was evaluated using regression analyses, with other potential influencing factors also considered. Results: A total of 102 participants were included. The average age was 56.1 (SD 15.2) years, and 57.8% were male. Participants with chronic UVP presented with shorter sedentary time (4,591 vs 5129 min/wk; P = 0.004), longer standing time (1443 vs 1165 min/wk; P = 0.025), higher vigorous PA (187 vs 107 min/wk; P = 0.005), and higher total PA (773 vs 623 min/wk; P = 0.003) compared to participants with acute/subacute UVP. In participants with acute/subacute UVP, variability in total PA was explained up to 54.7% by fear avoidance beliefs, etiology of the UVP, and gender (R 2 = 0.547, F 4,45 = 13.6, P < 0.001). In participants with chronic UVP, fear avoidance beliefs explained 4.1% of the variability in total PA (R 2 = 0.041, F 1,49 = 2.086, P = 0.155). Discussion and Conclusions: In acute/subacute UVP, assessing fear avoidance beliefs helps to understand physical inactivity. In chronic UVP, no significant association between fear avoidance beliefs and PA was observed. for more insights from the authors (see the video, Supplemental Digital Content, available at: http://links.lww.com/JNPT/A488). [ABSTRACT FROM AUTHOR]

Published
2025
Full Text
View/download PDF

49. Toward Dose Prediction at Point of Design.

Author

Van Rompaey, Dries, Ray Chaudhuri, Siladitya, Ahmad, Mazen, Cisar, Justin, Van Den Bergh, An, Ash, Jeremy, Wu, Zhe, Bryan, Marian C., Edwards, James P., DesJarlais, Renee, Wegner, Jörg Kurt, Ceulemans, Hugo, Mitra, Kaushik, and Polidori, David

Published
2024
Full Text
View/download PDF

50. Response to the letter to the editor on the article: a non-invasive, automated diagnosis of Menière’s disease using radiomics and machine learning on conventional magnetic resonance imaging—a multicentric, case-controlled feasibility study

Author

van der Lubbe, Marly F. J. A., Vaidyanathan, Akshayaa, de Wit, Marjolein, van den Burg, Elske L., Postma, Alida A., Bruintjes, Tjasse D., Bilderbeek-Beckers, Monique A. L., Dammeijer, Patrick F. M., Bossche, Stephanie Vanden, Van Rompaey, Vincent, Lambin, Philippe, van Hoof, Marc, and van de Berg, Raymond

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results