8 results on '"Van Riel, ACMJ"'
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2. Poster session Friday 13 December - AM: 13/12/2013, 08: 30–12: 30Location: Poster area
- Author
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Boerlage-Van Dijk, K, Van Riel, ACMJ, De Bruin-Bon, HACM, Wiegerinck, EMA, Koch, KT, Vis, MM, Meregalli, PG, Piek, JJ, Bouma, BJ, and Baan, J
- Published
- 2013
3. Poster Session Saturday 14 December - AM: 14/12/2013, 08:30-12:30 * Location: Poster area
- Author
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Muraru, D, Addetia, K, Veronesi, F, Corsi, C, Mor-Avi, V, Yamat, M, Weinert, L, Lang, RM, Badano, LP, Faita, F, Di Lascio, N, Bruno, RM, Bianchini, E, Ghiadoni, L, Sicari, R, Gemignani, V, Angelis, A, Ageli, K, Ioakimidis, N, Chrysohoou, C, Agelakas, A, Felekos, I, Vaina, S, Aznaourides, K, Vlachopoulos, C, Stefanadis, C, Nemes, A, Szolnoky, G, Gavaller, H, Gonczy, A, Kemeny, L, Forster, T, Ramalho, A, Placido, R, Marta, L, Menezes, M, Magalhaes, A, Cortez Dias, N, Martins, S, Almeida, A, Pinto, F, Nunes Diogo, A, Botezatu, C-D, Enache, R, Popescu, BA, Nastase, O, Coman, MC, Ghiorghiu, I, Calin, A, Rosca, M, Beladan, C, Ginghina, C, Grapsa, J, Cabrita, IZ, Durighel, G, Oregan, D, Dawson, D, Nihoyannopoulos, P, Pellicori, P, Kallvikbacka-Bennett, A, Zhang, J, Lukaschuk, E, Joseph, A, Bourantas, C, Loh, H, Bragadeesh, T, Clark, A, Cleland, JG, Kallvikbacka-Bennett, A, Pellicori, P, Lomax, S, Putzu, P, Diercx, R, Parsons, S, Dicken, B, Zhang, J, Clark, A, Cleland, JG, Vered, Z, Adirevitz, L, Dragu, R, Blatt, A, Karev, E, Malca, Y, Roytvarf, A, Marek, D, Sovova, E, Berkova, M, Cihalik, C, Taborsky, M, Lindqvist, P, Tossavainen, ERIK, Soderberg, S, Gonzales, M, Gustavsson, S, Henein, MY, Sonne, C, Bott-Fluegel, L, Hauck, S, Lesevic, H, Hadamitzky, M, Wolf, P, Kolb, C, Bandera, F, Pellegrino, M, Generati, G, Donghi, V, Alfonzetti, E, Castelvecchio, S, Menicanti, L, Guazzi, M, Buchyte, S, Rinkuniene, D, Jurkevicius, R, Smarz, K, Zaborska, B, Jaxa-Chamiec, T, Maciejewski, P, Budaj, A, Santoro, A, Federico Alvino, FA, Giovanni Antonelli, GA, Roberta Molle, RM, Matteo Bertini, MB, Stefano Lunghetti, SL, Sergio Mondillo, SM, Henri, C, Magne, J, Dulgheru, R, Laaraibi, S, Voilliot, D, Kou, S, Pierard, L, Lancellotti, P, Szulik, M, Stabryla-Deska, J, Kalinowski, M, Sliwinska, A, Szymala, M, Lenarczyk, R, Kalarus, Z, Kukulski, T, Investigators, TRUST CRT, Yiangou, K, Azina, C, Yiangou, A, Ioannides, M, Chimonides, S, Baysal, S, Pirat, B, Okyay, K, Bal, U, Muderrisoglu, H, Popovic, D, Ostojic, M, Petrovic, M, Vujisic-Tesic, B, Arandjelovic, A, Petrovic, I, Banovic, M, Popovic, B, Vukcevic, V, Damjanovic, S, Velasco Del Castillo, S, Onaindia Gandarias, JJ, Arana Achaga, X, Laraudogoitia Zaldumbide, E, Rodriguez Sanchez, I, Cacicedo De Bobadilla, A, Romero Pereiro, A, Aguirre Larracoechea, U, Salinas, T, Subinas, A, Elzbieciak, M, Wita, K, Grabka, M, Chmurawa, J, Doruchowska, A, Turski, M, Filipecki, A, Wybraniec, M, Mizia-Stec, K, Varho, VV, Karjalainen, PP, Lehtinen, T, Airaksinen, JKE, Ylitalo, A, Kiviniemi, TO, Gargiulo, P, Galderisi, M, D Amore, C, Lo Iudice, F, Savarese, G, Casaretti, L, Pellegrino, AM, Fabiani, I, La Mura, L, Perrone Filardi, P, Kim, J Y, Chung, WB, Yu, JS, Choi, YS, Park, CS, Youn, HJ, Lee, MY, Nagy, AI, Manouras, A, Gunyeli, E, Gustafsson, U, Shahgaldi, K, Winter, R, Johnsson, J, Zagatina, A, Krylova, L, Zhuravskaya, N, Vareldzyan, Y, Tyurina, TV, Clitsenko, O, Khalifa, E A, Ashour, Z, Elnagar, W, Jung, IH, Seo, HS, Lee, SJ, Lim, DS, Mizariene, V, Verseckaite, R, Janenaite, J, Jonkaitiene, R, Jurkevicius, R, Sanchez Espino, AD, Bonaque Gonzalez, JC, Merchan Ortega, G, Bolivar Herrera, N, Ikuta, I, Macancela Quinones, JJ, Gomez Recio, M, Silva Fazendas Adame, P R, Caldeira, D, Stuart, B, Almeida, S, Cruz, I, Ferreira, A, Freire, G, Lopes, L, Cotrim, C, Pereira, H, Mediratta, A, Addetia, K, Moss, JD, Nayak, HM, Yamat, M, Weinert, L, Mor-Avi, V, Lang, RM, Al Amri, I, Debonnaire, P, Van Der Kley, F, Schalij, MJ, Bax, JJ, Ajmone Marsan, N, Delgado, V, Schmidt, F P, Gniewosz, T, Jabs, A, Munzel, T, Jansen, T, Kaempfner, D, Hink, U, Von Bardeleben, RS, Jose, J, George, OK, Joseph, G, Jose, J, Adawi, S, Najjar, R, Ahronson, D, Shiran, A, Van Riel, ACMJ, Boerlage - Van Dijk, K, De Bruin - Bon, HACM, Araki, M, Meregalli, PG, Koch, KT, Vis, MM, Mulder, BJM, Baan, J, Bouma, BJ, Marciniak, A, Elton, D, Glover, K, Campbell, I, Sharma, R, Batalha, S, Lourenco, C, Oliveira Da Silva, C, Manouras, A, Shahgaldi, K, Caballero, L, Garcia-Lara, J, Gonzalez-Carrillo, J, Oliva, MJ, Saura, D, Garcia-Navarro, M, Espinosa, MD, Pinar, E, Valdes, M, De La Morena, G, Barreiro Perez, M, Lopez Perez, M, Roy, D, Brecker, S, Sharma, R, Venkateshvaran, A, Dash, P K, Sola, S, Barooah, B, Govind, S C, Winter, R, Shahgaldi, K, Brodin, L A, Manouras, A, Saura Espin, D, Caballero Jimenez, L, Gonzalez Carrillo, J, Oliva Sandoval, MJ, Lopez Ruiz, M, Garcia Navarro, M, Espinosa Garcia, MD, Valdes Chavarri, M, De La Morena Valenzuela, G, Gatti, G, Dellangela, L, Pinamonti, B, Benussi, B, Sinagra, G, Pappalardo, A, Group, Heart Muscle Disease Study, Hernandez, V, Saavedra, J, Gonzalez, A, Iglesias, P, Civantos, S, Guijarro, G, Monereo, S, Ikeda, M, Toh, N, Oe, H, Tanabe, Y, Watanabe, N, Ito, H, Ciampi, Q, Cortigiani, L, Pratali, L, Rigo, F, Villari, B, Picano, E, Sicari, R, Yoon, JH, Sohn, JW, Kim, YJ, Chang, HJ, Hong, GR, Kim, TH, Ha, JW, Choi, BW, Rim, SJ, Choi, EY, Tibazarwa, K, Sliwa, K, Wonkam, A, Mayosi, BM, Oryshchyn, N, Ivaniv, Y, Pavlyk, S, Lourenco, M R, Azevedo, O, Moutinho, J, Nogueira, I, Fernandes, M, Pereira, V, Quelhas, I, Lourenco, A, Sunbul, M, Tigen, K, Karaahmet, T, Dundar, C, Ozben, B, Guler, A, Cincin, A, Bulut, M, Sari, I, Basaran, Y, Baydar, O, Kadriye Kilickesmez, KK, Ugur Coskun, UC, Polat Canbolat, PC, Veysel Oktay, VO, Umit Yasar Sinan, US, Okay Abaci, OA, Cuneyt Kocas, CK, Sinan Uner, SU, Serdar Kucukoglu, SK, Zaroui, A, Mourali, MS, Ben Said, R, Asmi, M, Aloui, H, Kaabachi, N, Mechmeche, R, Saberniak, J, Hasselberg, NE, Borgquist, R, Platonov, PG, Holst, AG, Edvardsen, T, Haugaa, KH, Lourenco, M R, Azevedo, O, Nogueira, I, Moutinho, J, Fernandes, M, Pereira, V, Quelhas, I, Lourenco, A, Eran, A, Yueksel, D, Er, F, Gassanov, N, Rosenkranz, S, Baldus, S, Guedelhoefer, H, Faust, M, Caglayan, E, Matveeva, N, Nartsissova, G, Chernjavskij, A, Ippolito, R, De Palma, D, Muscariello, R, Santoro, C, Raia, R, Schiano-Lomoriello, V, Gargiulo, F, Galderisi, M, Lipari, P, Bonapace, S, Zenari, L, Valbusa, F, Rossi, A, Lanzoni, L, Canali, G, Molon, G, Campopiano, E, Barbieri, E, Ikonomidis, I, Varoudi, M, Papadavid, E, Theodoropoulos, K, Papadakis, I, Pavlidis, G, Triantafyllidi, H, Anastasiou - Nana, M, Rigopoulos, D, Lekakis, J, Sunbul, M, Tigen, K, Ozen, G, Durmus, E, Kivrak, T, Cincin, A, Ozben, B, Atas, H, Direskeneli, H, Basaran, Y, Stevanovic, A, Dekleva, M, Trajic, S, Paunovic, N, Simic, A, Khan, SG, Mushemi-Blake, S, Jouhra, F, Dennes, W, Monaghan, M, Melikian, N, Shah, AM, Division, Cardiovascular, Excellence, Kings BHF Centre of, Maceira Gonzalez, A M, Lopez-Lereu, MP, Monmeneu, JV, Igual, B, Estornell, J, Boraita, A, Kosmala, W, Rojek, A, Bialy, D, Mysiak, A, Przewlocka-Kosmala, M, Popescu, I, Mancas, S, Mornos, C, Serbescu, I, Ionescu, G, Ionac, A, Gaudron, P, Niemann, M, Herrmann, S, Hu, K, Liu, D, Wojciech, K, Frantz, S, Bijnens, B, Ertl, G, Weidemann, F, Maceira Gonzalez, A M, Cosin-Sales, J, Ruvira, J, Diago, JL, Aguilar, J, Igual, B, Lopez-Lereu, MP, Monmeneu, J, Estornell, J, Cruz, C, Pinho, T, Madureira, AJ, Lebreiro, A, Dias, CC, Ramos, I, Silva Cardoso, J, Julia Maciel, M, De Meester, P, Van De Bruaene, A, Herijgers, P, Voigt, J-U, Budts, W, Franzoso, F, Voser, EM, Wohlmut, C, Kellenberger, CJ, Valsangiacomo Buechel, E, Carrero, C, Benger, J, Parcerisa, MF, Falconi, M, Oberti, PF, Granja, M, Cagide, AM, Del Pasqua, A, Secinaro, A, Antonelli, G, Iacomino, M, Toscano, A, Chinali, M, Esposito, C, Carotti, A, Pongiglione, G, Rinelli, G, Youssef Moustafa, A, Al Murayeh, M, Al Masswary, A, Al Sheikh, K, Moselhy, M, Dardir, MD, Deising, J, Butz, T, Suermeci, G, Liebeton, J, Wennemann, R, Tzikas, S, Van Bracht, M, Prull, MW, Trappe, H-J, Martin Hidalgo, M, Delgado Ortega, M, Ruiz Ortiz, M, Mesa Rubio, D, Carrasco Avalos, F, Seoane Garcia, T, Pan Alvarez-Ossorio, M, Lopez Aguilera, J, Puentes Chiachio, M, Suarez De Lezo Cruz Conde, J, Petrovic, M T, Giga, V, Stepanovic, J, Tesic, M, Jovanovic, I, Djordjevic-Dikic, A, Generati, G, Pellegrino, M, Bandera, F, Donghi, V, Alfonzetti, E, Guazzi, M, Piatkowski, R, Kochanowski, J, Scislo, P, Opolski, G, Zagatina, A, Zhuravskaya, N, Krylova, L, Vareldzhyan, Y, Tyurina, TV, Clitsenko, O, Bombardini, T, Gherardi, S, Leone, O, Picano, E, Michelotto, E, Ciccarone, A, Tarantino, N, Ostuni, V, Rubino, M, Genco, W, Santoro, G, Carretta, D, Romito, R, Colonna, P, foundation, Cassa di Risparmio di Puglia, Cameli, M, Lunghetti, S, Lisi, M, Curci, V, Cameli, P, Focardi, M, Favilli, R, Galderisi, M, Mondillo, S, Hoffmann, R, Barletta, G, Von Bardeleben, S, Kasprzak, J, Greis, C, Vanoverschelde, J, Becher, H, Machida, T, Izumo, M, Suzuki, K, Kaimijima, R, Mizukoshi, K, Manabe-Uematsu, M, Takai, M, Harada, T, Akashi, YJ, Medicine., St. Marianna University School of, Cardiology, Division of, Martin Garcia, A, Arribas-Jimenez, A, Cruz-Gonzalez, I, Nieto, F, Iscar, A, Merchan, S, Martin-Luengo, C, Brecht, A, Theres, L, Spethmann, S, Dreger, H, Baumann, G, Knebel, F, Jasaityte, R, Heyde, B, Rademakers, F, Claus, P, Dhooge, J, Lervik Nilsen, L C, Lund, J, Brekke, B, Stoylen, A, Giraldeau, G, Duchateau, N, Gabrielli, L, Penela, D, Evertz, R, Mont, L, Brugada, J, Berruezo, A, Bijnens, BH, Sitges, M, Kordybach, M, Kowalski, M, Hoffman, P, Pilichowska, E, Zaborska, B, Baran, J, Kulakowski, P, Budaj, A, Wahi, S, Vollbon, W, Leano, R, Thomas, A, Bricknell, K, Holland, D, Napier, S, Stanton, T, Teferici, D, Qirko, S, Petrela, E, Dibra, A, Bajraktari, G, Bara, P, Sanchis Ruiz, L, Gabrielli, L, Andrea, R, Falces, C, Duchateau, N, Perez-Villa, F, Bijnens, B, Sitges, M, Sulemane, S, Panoulas, VF, Bratsas, AH, Tam, FW, Nihoyannopoulos, P, Abduch, MCD, Alencar, AM, Coracin, FL, Barban, A, Saboya, R, Dulley, FL, Mathias, W, Vieira, MLC, Buccheri, S, Mangiafico, S, Arcidiacono, A, Bottari, VE, Leggio, S, Tamburino, C, Monte, I P, Cruz, C, Lebreiro, A, Pinho, T, Dias, CC, Silva Cardoso, J, Julia Maciel, M, Spitzer, E, Beitzke, D, Kaneider, A, Pavo, N, Gottsauner-Wolf, M, Wolf, F, Loewe, C, Mushtaq, S, Andreini, D, Pontone, G, Bertella, E, Conte, E, Baggiano, A, Annoni, A, Cortinovis, S, Fiorentini, C, Pepi, M, Gustafsson, M, Alehagen, U, Dahlstrom, U, Johansson, P, Faden, G, Faggiano, P, Albertini, L, Reverberi, C, Gaibazzi, N, Taylor, R J, Moody, WE, Umar, F, Edwards, NC, Townend, JN, Steeds, RP, Leyva, F, Mihaila, S, Muraru, D, Piasentini, E, Peluso, D, Casablanca, S, Naso, P, Puma, L, Iliceto, S, Vinereanu, D, Badano, LP, Ciciarello, F L, Agati, L, Cimino, S, De Luca, L, Petronilli, V, Fedele, F, and Tsverava, M
- Abstract
Purpose: Transthoracic 3D echocardiography (3DE) allows an unparalleled opportunity for quantifying the dynamic changes of the tricuspid annulus (TA). Accordingly, our aims were: (I) to assess the determinants of TA size during cardiac cycle in healthy subjects; (II) to propose an approach and timing for TA sizing using 3DE. Methods: In 50 healthy volunteers (45±14 yrs, range 18-74, 27 males, with no risk factors, symptoms, signs or history of cardiovascular disease and on no medication), a full-volume dataset of the right ventricle (RV) containing the tricuspid valve (TV) was acquired (Vivid E9, GE Healthcare). TA diameters (septo-lateral, SL; antero-posterior, AP) and areas were measured on multiplanar images (Flexi-slice, EchoPac BT12, GE Healthcare) at 5 time points during the cardiac cycle: OS (onset of systole, at TV closure); MS (mid-systole); ES (end-systole); ED (onset of diastole); LD (late diastole, after the P wave). RV volumes and ejection fraction (EF) were analyzed with commercial software (4D RV analysis, TomTec, D). Results: Temporal resolution of the 3D datasets was 32±4 vps (range 24-53). TA areas were more closely correlated with RV volumes and body surface area (BSA) than with either SL or AP diameters. TA areas increased during systole from OS (3.9±0.6 cm2/m2) to ES (4.9±0.8 cm2/m2) and reached its largest area in LD (6.7±1.0 cm2/m2). All 5 TA areas were correlated with BSA (r range 0.57-0.62) and RV volumes (r ranges 0.53-0.60 for end-diastolic volume and 0.43-0.50 for end-systolic volume, p<0.0001 for all). Indexed TA areas were not related to either age or gender. With multivariable analysis, both RV end-diastolic volume and BSA determined TA areas during systole and early diastole, while TA area at LD and at OS were independently related with BSA only. Conclusions: In healthy subjects, the main determinants of TA size are RV volume and BSA. The largest TA area occurs at LD and is independently related with BSA only. Therefore, normative values should be based on TA areas measured at LD and indexed for BSA. However, the rapid change in TA areas occurring from LD to OS underscores the importance of adequate temporal resolution of 3DE data sets for reliable TA measurements.
- Published
- 2013
- Full Text
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4. Poster session Friday 13 December - AM: 13/12/2013, 08:30-12:30 * Location: Poster area
- Author
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Gertsen, M, Nemes, A, Szolnoky, G, Altmayer, A, Gavaller, H, Kemeny, L, Forster, T, Park, J R, Jo, SY, Kim, KH, Kho, JS, Kwack, CH, Hwang, JY, Popovic, D, Ostojic, MC, Petrovic, M, Vujisic-Tesic, B, Arandjelovic, A, Banovic, M, Vukcevic, V, Petrovic, I, Popovic, B, Damjanovic, S, Placido, R, Marta, L, Ramalho, AR, Nobre Menezes, M, Cortez-Dias, N, Martins, S, Goncalves, S, Almeida, AG, Silva-Marques, J, Nunes-Diogo, A, Germanakis, I, Kakouri, P, Karachaliou, M, Vassilaki, M, Chatzi, L, Roumeliotaki, T, Kogevinas, M, Horst, J-P, Kelter-Kloepping, A, Koerperich, H, Barth, P, Haas, NA, Kececioglu, D, Laser, KT, Laser, KT, Horst, J-P, Kelter-Kloepping, A, Barth, P, Haas, NA, Kececioglu, D, Koerperich, H, Samiei, N, Nabati, M, Azari-Jafari, M, Vakili-Zarch, A, Parsaee, M, Haghjoo, M, Ahmed, A J, Val-Mejias, J E, Von Bulow, F M, Baltussen, E J M, Darban, AM, Claus, P, Voigt, JU, Rodriguez Munoz, DA, Moya Mur, JL, Gonzalez, A, Garcia Martin, A, Becker Filho, D, Fernandez Santos, S, Lazaro Rivera, C, Recio Vazquez, M, Fernandez Golfin, C, Zamorano Gomez, JL, Bandera, F, Pellegrino, M, Generati, G, Alfonzetti, E, Donghi, V, Castelvecchio, S, Garatti, A, Menicanti, L, Guazzi, M, Kowalik, E, Klisiewicz, A, Hoffman, P, Kim, EJ, Cho, I J, Oh, J, Chang, HJ, Park, J, Shin, S, Shim, CY, Hong, GR, Ha, JW, Chung, N, Park, JH, Lee, HS, Kim, HS, Ahn, KT, Kim, JH, Lee, JH, Choi, SW, Jeong, JO, Seong, IW, Holzendorf, V, Gelbrich, G, Wachter, R, Loeffler, M, Pieske, BM, Broda, A, Edelmann, F, Failure, German Competence Network for Heart, Kim, YH, Kim, DH, Kim, SH, Ahn, JC, Song, WH, Hashimoto, G, Suzuki, M, Yoshikawa, H, Otsuka, T, Kusunose, Y, Nakamura, M, Sugi, K, De Knegt, M C, Biering-Sorensen, T, Sogaard, P, Sivertsen, J, Jensen, JS, Mogelvang, R, Murbraech, K, Smeland, KH, Holte, H, Loge, JH, Kiserud, CE, Aakhus, S, Peteiro, J, Gargallo-Fernandez, P, Garcia-Guimaraes, M, Bouzas-Mosquera, A, Yanez-Wronenburger, JC, Martinez-Ruiz, D, Castro-Beiras, A, Trzcinski, PT, Jaskowski, MJ, Nowak, JN, Pawlus, MP, Figiel, LF, Kasprzak, JDK, Lipiec, PL, Zhong, L, Su, Y, Teo, SK, Le, TT, Tan, RS, Tesic, M, Djordjevic-Dikic, A, Giga, V, Jovanovic, I, Paunovic, I, Petrovic, MT, Trifunovic, D, Beleslin, B, Stepanovic, J, Vujisic-Tesic, B, Parato, V M, Partemi, M, Nardini, E, Pasanisi, E, Park, T-H, Lee, J-E, Lee, D-H, Park, J-S, Park, K, Kim, M-H, Kim, Y-D, Vegsundvag, J, Holte, E, Wiseth, R, Hegbom, K, Hole, T, Fusini, L, Tamborini, G, Ghulam Ali, S, Muratori, M, Gripari, P, Cefalu, C, Maffessanti, F, Celeste, F, Alamanni, F, Pepi, M, Negrea, SL, Alexandrescu, C, Rossi, P, Iacuzio, L, Dreyfus, G, Moatemri, F, Mahdhaoui, A, Bouraoui, H, Ernez, S, Jeridi, G, Yuan, L, Feng, JL, Jin, X Y, Seoane Garcia, T, Delgado Ortega, M, Mesa Rubio, D, Ruiz Ortiz, M, Martin Hidalgo, M, Carrasco Avalos, F, Casares Mediavilla, J, Alados, P, Lopez Granados, A, Suarez De Lezo Cruz Conde, J, Mutuberria Urdaniz, M, Rodriguez-Palomares, JF, Baneras-Rius, JF, Acosta-Velez, JG, Buera-Surribas, I, Gonzalez-Alujas, MT, Teixido, G, Evangelista, A, Tornos, P, Garcia-Dorado, D, Iliuta, L, Boerlage-Van Dijk, K, Van Riel, ACMJ, De Bruin-Bon, HACM, Wiegerinck, EMA, Koch, KT, Vis, MM, Meregalli, PG, Piek, JJ, Bouma, BJ, Baan, J, Enache, R, Muraru, D, Piazza, R, Popescu, BA, Coman, M, Calin, A, Rosca, M, Beladan, CC, Nicolosi, GL, Ginghina, C, Song, JM, Kim, JJ, Ha, TY, Jung, SH, Hwang, IS, Lee, IC, Sun, BJ, Kim, DH, Kang, DH, Song, JK, Sturmberger, T, Ebner, CE, Aichinger, J, Tkalec, W, Niel, J, Steringer-Mascherbauer, R, Kabicher, G, Winter, S, Nesser, HJ, Hofmann-Bowman, M, Lin Yan, LY, Puri, TP, Chin, C W L, Doris, M, Shah, A, Mills, N, Semple, S, Prasad, S, White, A, Dweck, M, Newby, D, Debonnaire, P, Al Amri, I, Leong, DP, Joyce, E, Katsanos, S, Kamperidis, V, Schalij, MJ, Bax, JJ, Ajmone Marsan, N, Delgado, V, Cerin, G, Popa, B A, Lanzillo, G, Benea, D, Karazanishvili, L, Diena, M, Dedobbeleer, C, Schnell, F, Jotrand, E, El Mourad, M, Thebault, C, Plein, D, Donal, E, Unger, P, Spampinato, RA, Tasca, M, Da Rocha E Silva, JG, Strotdrees, E, Schloma, V, Dmitrieva, Y, Mende, M, Borger, MA, Mohr, FW, Veronesi, F, Muraru, D, Addetia, K, Corsi, C, Lamberti, C, Lang, RM, Mor-Avi, V, Badano, LP, Zemanek, D, Tomasov, P, Belehrad, M, Kara, T, Veselka, J, Igual Munoz, B, Estornell Erill, JORDI, Maceira Gonzalez Alicia, AMG, Monmeneu Menadas, JVMM, Lopez Lereu Pilar, PLL, Molina Aguilar, PMA, Domingo-Valero, DDV, Osca Asensi, JOA, Zorio Grima, EZG, Salvador Sanz Antonio, ASS, Ibrahimi, P, Bajraktari, G, Poniku, A, Hysenaj, V, Ahmeti, A, Jashari, F, Haliti, E, Henein, MY, Maramao, F, Conde, Y, Maramao, L, Rulli, F, Roussin, I, Drakopoulou, M, Bhattacharyya, S, Simpkin, V, Sharma, R, Rosen, S, Prasad, S, Senior, R, Lyon, AR, Kimura, K, Tanimoto, T, Akasaka, T, Fijalkowski, M, Jaguszewski, M, Fijalkowska, M, Nowak, R, Galaska, R, Rojek, A, Narkiewicz, K, Rynkiewicz, A, Azevedo, O, Marques, N, Cruz, I, Picarra, B, Lima, R, Amado, J, Pereira, V, Almeida, AR, SUNSHINE, Zito, C, Crea, P, Cusma Piccione, M, Vriz, O, Bitto, A, Minisini, R, Madaffari, A, Acri, E, Oteri, A, Carerj, S, Leggio, S, Buccheri, S, Tamburino, C, Monte, I P, Mihalcea, D, Florescu, M, Enescu, OA, Magda, LS, Radu, E, Acasandrei, AM, Balanescu, P, Rimbas, RC, Jinga, D, Vinereanu, D, 112/2011, Research grant, Miyoshi, T, Tanaka, H, Kaneko, A, Matsumoto, K, Imanishi, J, Motoji, Y, Mochizuki, Y, Minami, H, Kawai, H, Hirata, K, Ryu, SK, Shin, DG, Son, JW, Choi, JH, Goh, CW, Choi, JW, Park, JY, Hong, GR, Le Page, P, Mitchell, ARJ, Maclachlan, HI, Hurry, RW, Villagraz Tecedor, L, Jimenez Lopez Guarch, C, Alonso Chaterina, S, Mayordomo Gomez, S, Blazquez Arrollo, L, Lombera Romero, F, Lopez Melgar, B, Escribano Subias, MP, Lichodziejewska, B, Kurnicka, K, Goliszek, S, Kostrubiec, M, Dzikowska Diduch, O, Krupa, M, Grudzka, K, Ciurzynski, M, Palczewski, P, Pruszczyk, P, Lovric, D, Carmona, C, Bergerot, C, Schnell, F, Thibault, H, Barthelet, M, Ninet, J, Revel, D, Croisille, P, Derumeaux, G, 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L, Tomaszewski, A, Sinkiewicz, W, Wojciechowska, C, Aggeli, C, Felekos, I, Stergiou, P, Roussakis, G, Kakiouzi, V, Kastellanos, S, Koutagiar, I, Stefanadis, C, Bouzas Mosquera, A, Peteiro, J, Alvarez-Garcia, N, Broullon, FJ, Garcia-Guimaraes, MM, Martinez-Ruiz, D, Yanez-Wonenburger, JC, Bouzas-Zubeldia, B, Fabregas, R, Castro-Beiras, A, Brugger, N, Huerzeler, M, Wustmann, K, Wahl, A, Steck, H, Seiler, C, Sarwar, R, Malhotra, A, Wong, KC, Betts, TR, Bashir, Y, Rajappan, K, Newton, JD, Casanova Rodriguez, C, Cano Carrizal, R, Iglesias Del Valle, D, Martin Penato Molina, A, Garcia Garcia, A, Prieto Moriche, E, Alvarez Rubio, J, Paredes Gonzalez, B, De Juan Baguda, J, Plaza Perez, I, Van Den Oord, SCH, Akkus, Z, Roeters Van Lennep, JE, Bosch, JG, Van Der Steen, AFW, Sijbrands, EJG, Schinkel, AFL, Muraru, D, Calore, C, Badano, LP, Melacini, C, Mihaila, S, Peluso, D, Puma, L, Kocabay, G, Rizzon, G, Iliceto, S, Bochard Villanueva, B, Paya-Serrano, R, Garcia-Gonzalez, P, Fabregat-Andres, O, Perez-Bosca, JL, Cubillos-Arango, A, Ferrando-Beltran, M, Chacon-Hernandez, N, Albiach-Montanana, C, Ridocci-Soriano, F, Ancona, R, Comenale Pinto, S, Caso, P, Arenga, F, Coppola, MG, Calabro, R, Tarr, A, Stoebe, S, Pfeiffer, D, Hagendorff, A, Hollekim, SM, Bjorgaas, MR, Tjonna, AE, Wisloff, U, Ingul, CB, (CERG), Cardiac Exercise Research Group, Oreto, L, Zito, C, Cusma-Piccione, M, Calabro, MP, Todaro, MC, Vita, GL, Messina, S, Vita, G, Sframeli, M, Carerj, S, Remoli, R, Lamberti, F, Bellini, C, Mercurio, M, Dottori, S, Bellusci, F, Mazzuca, V, Gaspardone, A, Rimbas, RC, Enescu, OA, Mihaila, S, Ciobanu, A, Vinereanu, D, Henri, C, Magne, J, Dulgheru, R, Laaraibi, S, Voilliot, D, Kou, S, Pierard, L, Lancellotti, P, Wellnhofer, E, Kriatselis, C, Gerds-Li, H, Furundzija, VESNA, Thanabalasingam, U, Fleck, E, Graefe, M, Kouris, N, Keramida, K, Karidas, V, Kostopoulos, V, Kostakou, P, Mprempos, G, Olympios, CD, Duchateau, N, Giraldeau, G, Gabrielli, L, Penela, D, Evertz, R, Mont, L, Brugada, J, Berruezo, A, Bijnens, BH, Sitges, M, Bernard, A, Donal, E, Reynaud, A, Schnell, F, Daubert, JC, Leclercq, C, Hernandez, A, Keramida, K, Kouris, N, Kostopoulos, V, Karidas, V, Dagre, A, Ntarladimas, I, Damaskos, D, Stamatelatou, M, Olympios, CD, Panetta, G L, Peraldo Neja, C, Urbano Moral, JA, Evangelista, A, Azzolini, P, Gaudio, C, Pandian, NG, Barbier, P, Mirea, O, Savioli, G, Cefalu, C, Guglielmo, M, Fusini, L, Maltagliati, A, Hamdy, AM, Fereig, HM, Nabih, MA, Abdel-Aziz, A, Ali, AA, Buccheri, S, Mangiafico, S, Leggio, S, B, VE, Tropea, L, Tamburino, C, Monte, I P, Garcia-Gonzalez, P, Chacon-Hernandez, N, Cozar-Santiago, P, Fabregat-Andres, O, Sanchez-Jurado, R, Higueras-Ortega, L, Albiach-Motanana, C, Perez-Bosca, JL, Paya-Serrano, R, Ridocci-Soriano, F, Flori, M, Valette, F, Guijarro, D, Pallardy, A, Le Tourneau, T, Kraeber-Bodere, F, Piriou, N, Saxena, A, Ramakrishnan, S, Tulunay Kaya, C, Ongun, A, Kilickap, M, Candemir, B, Altin, AT, Gerede, M, Ozcan, OU, Erol, C, Yue, WS, Yang, F, Huang, D, Gu, P, Luo, Y, Lv, Z, Siu, CW, Tse, HF, Yiu, KH, Saura Espin, D, Lopez Cuenca, A, Espinosa Garcia, MD, Oliva Sandoval, MJ, Lopez Ruiz, M, Gonzalez Carrillo, J, Garcia Navarro, MJ, Valdes Chavarri, M, De La Morena Valenzuela, G, Gustafsson, U, Spuhler, JH, Hoffman, J, Brodin, LÅ, Kisko, A, Dernarova, L, Hudakova, A, Santova, T, Jakubikova, M, Mikulak, M, Horlenko, O, Kishko, N, Svystak, V, Shyp, A, Faden, G, Gaibazzi, N, Rigo, F, Mureddu, GF, Moreo, A, Bussadori, G, Facchetti, R, Cesana, F, Giannattasio, C, Faggiano, P, and group, APRES collaborative
- Abstract
Pulmonary vascular dysfunction is claimed to be a contributor to the development of pulmonary hypertension (PH). Impaired systemic vascular reactivity is one of the essential factors in the pathogenesis of cardiovascular disease. The aim of the investigation was to study whether there is any association between systemic vascular function and pulmonary artery pressure (PAP) in patients who have associated causes for PH development, such as coronary heart disease (CHD) and chronic obstructive pulmonary disease (COPD). Methods: The brachial artery vasodilator responses were measured by the ultrasound technique in twenty patients with mild to moderate COPD (group I) and twenty age–matched and COPD stage-matched patients who had past history of myocardial infarction (NYHA II) (group II).Conventional echocardiographic variables were measured in the said patients too. Results: Both flow-mediated dilatation (FMD) and nitrate-mediated dilatation (NMD) were significantly lower, and PAP was significantly higher in the group II patients compared to the same parameters of group I patients. NMD was inversely correlated with PAP (r=-0.7, p=0.02) in group I patients. There was no interrelation between FMD and PAP in patients from group I. Neither FMD nor NMD were correlated with PAP in group II patients. A significant positive correlation between PAP and left ventricular mass index (r=0.8, p=0.003) was revealed in the said patients as well. Conclusions: Attenuated vasodilator response of brachial artery to nitroglycerine is associated with PAP elevation in COPD patients. PH is closely related to cardiac remodeling in COPD patients in whom CHD developed. These data suggest different "stages" of vascular and cardiac remodeling in patients with COPD alone and in coexistence with CHD. The obtained data can be useful in the selection of treatment as regards these patient categories.
- Published
- 2013
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5. Mortality in pulmonary arterial hypertension due to congenital heart disease: Serial changes improve prognostication.
- Author
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Schuijt MTU, Blok IM, Zwinderman AH, van Riel ACMJ, Schuuring MJ, de Winter RJ, Duijnhouwer AL, van Dijk APJ, Mulder BJM, and Bouma BJ
- Subjects
- Adult, Aged, Cohort Studies, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Time Factors, Heart Defects, Congenital diagnostic imaging, Heart Defects, Congenital mortality, Hypertension, Pulmonary diagnostic imaging, Hypertension, Pulmonary mortality
- Abstract
Background: Adult patients with pulmonary arterial hypertension due to congenital heart disease (PAH-CHD) suffer from high mortality. This underlines the importance of adequate risk stratification to guide treatment decisions. Several baseline parameters are associated with mortality, however, their prognostic value may weaken after years of follow-up. Therefore we investigated the prognostic value of serial changes in standard clinical parameters in PAH-CHD., Methods: In this prospective observational cohort study we included consecutive PAH-CHD adults, between 2005 and 2016. Control visits to the outpatient clinic were standardized, including functional, biochemical and echocardiographic tests, according to the guidelines. The prognostic value of serial changes was determined with time-dependent Cox regression., Results: Ninety-two patients with PAH-CHD were included (age 43±15years, 34% male, 38% Down, 73% Eisenmenger). During a median follow-up of 6.0 (IQR 3.7-9.3) years, 35 (38%) patients died. Serial changes in World Health Organization functional classification (WHO-FC, HR 18.34 for onset class IV), six-minute walk distance (6-MWD, HR 0.65 per 50m), oxygen saturation at peak exercise (peak SaO
2 , HR 0.74 per 5%), NTproBNP (HR 2.25 per 1000ng/l) and echocardiographic right ventricular function (TAPSE, HR 0.80 per 0.5cm) significantly predicted mortality. Moreover, serial changes in these parameters were more potent predictors compared to baseline parameters, based on reduction in -2 log likelihood., Conclusions: Serial changes in standard clinical parameters have more prognostic value compared to baseline parameters in PAH-CHD. Our results emphasize the importance of screening for serial changes since periodical assessment could guide treatment decisions to delay disease progression., (Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.)- Published
- 2017
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6. Hemodynamic and metabolic characteristics associated with development of a right ventricular outflow tract pressure gradient during upright exercise.
- Author
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van Riel ACMJ, Systrom DM, Oliveira RKF, Landzberg MJ, Mulder BJM, Bouma BJ, Maron BA, Shah AM, Waxman AB, and Opotowsky AR
- Subjects
- Adult, Cardiac Catheterization, Echocardiography, Female, Humans, Male, Middle Aged, Exercise, Hemodynamics, Pulmonary Artery physiology, Ventricular Function, Right physiology, Ventricular Pressure physiology
- Abstract
Background: We recently reported a novel observation that many patients with equal resting supine right ventricular(RV) and pulmonary artery(PA) systolic pressures develop an RV outflow tract(RVOT) pressure gradient during upright exercise. The current work details the characteristics of patients who develop such an RVOT gradient., Methods: We studied 294 patients (59.7±15.5 years-old, 49% male) referred for clinical invasive cardiopulmonary exercise testing, who did not have a resting RVOT pressure gradient defined by the simultaneously measured peak-to-peak difference between RV and PA systolic pressures., Results: The magnitude of RVOT gradient did not correspond to clinical or hemodynamic findings suggestive of right heart failure; rather, higher gradients were associated with favorable exercise findings. The presence of a high peak RVOT gradient (90th percentile, ≥33mmHg) was associated with male sex (70 vs. 46%, p = 0.01), younger age (43.6±17.7 vs. 61.8±13.9 years, p<0.001), lower peak right atrial pressure (5 [3-7] vs. 8 [4-12]mmHg, p<0.001), higher peak heart rate (159±19 vs. 124±26 beats per minute, p<0.001), and higher peak cardiac index (8.3±2.3 vs. 5.7±1.9 L/min/m2, p<0.001). These associations persisted when treating peak RVOT as a continuous variable and after age and sex adjustment. At peak exercise, patients with a high exercise RVOT gradient had both higher RV systolic pressure (78±11 vs. 66±17 mmHg, p<0.001) and lower PA systolic pressure (34±8 vs. 50±19 mmHg, p<0.001)., Conclusions: Development of a systolic RV-PA pressure gradient during upright exercise is not associated with an adverse hemodynamic exercise response and may represent a normal physiologic finding in aerobically fit young people.
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- 2017
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7. From bosentan to macitentan for pulmonary arterial hypertension and adult congenital heart disease: Further improvement?
- Author
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Blok IM, van Riel ACMJ, van Dijk APJ, Mulder BJM, and Bouma BJ
- Subjects
- Adult, Antihypertensive Agents therapeutic use, Bosentan, Cohort Studies, Female, Follow-Up Studies, Heart Defects, Congenital diagnosis, Humans, Hypertension, Pulmonary diagnosis, Male, Middle Aged, Prospective Studies, Drug Substitution trends, Heart Defects, Congenital drug therapy, Hypertension, Pulmonary drug therapy, Pyrimidines therapeutic use, Sulfonamides therapeutic use
- Published
- 2017
- Full Text
- View/download PDF
8. Treatment of pulmonary arterial hypertension in congenital heart disease in Singapore versus the Netherlands: age exceeds ethnicity in influencing clinical outcome.
- Author
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van Riel ACMJ, Schuuring MJ, van Hessen ID, van Dijk APJ, Hoendermis ES, Yip JW, Mulder BJM, and Bouma BJ
- Abstract
Background: Advanced treatment of pulmonary arterial hypertension (PAH) in congenital heart disease (CHD) is increasingly applied worldwide following the-mainly Western world based-international PAH-CHD guidelines. However, studies comparing clinical presentation and outcome after the initiation of PAH-specific treatment are lacking. We aimed to analyse this in a Singaporean and Dutch cohort of PAH-CHD patients., Methods: Adult CHD patients starting PAH-specific therapy, enrolled in two nationwide registries, were analysed. Patients received phosphodiesterase-type-5 inhibitors, endothelin receptor antagonists, or a combination. Change in six-minute walk test (6MWT) during follow-up was analysed using linear mixed model analysis. Determinants for mortality were assessed using Cox proportional hazard analyses., Results: A total of 74 patients, 45 Dutch (mean age 47 ± 14 years) and 29 Singaporean (mean age 41 ± 14 years) were analysed. Despite a lower 6MWT (312 versus 395 metres, p = 0.01) and peak VO2 (35 versus 49 % of predicted, p = 0.01) at baseline in Singaporean patients, the treatment effect was similar in the two populations. Age at initiation of therapy (per 5 year lower age, β = + 4.5, p = 0.017) was the strongest predictor of improvement in exercise capacity, corrected for ethnicity, baseline 6MWT, sex and CHD defect., Conclusions: Patients from Singapore had a worse clinical performance at baseline compared with the PAH-CHD patients from the Netherlands. No relation between ethnicity and improvement in 6MWT after PAH-specific therapy was found. Age at initiation of PAH-specific therapy was the strongest predictor of treatment efficacy and mortality, emphasising the need for early initiation of treatment in these patients.
- Published
- 2016
- Full Text
- View/download PDF
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