Search

Your search keyword '"Van Oosterhout EJ"' showing total 2 results
Start Over Author "Van Oosterhout EJ"
2 results on '"Van Oosterhout EJ"'

1. The incidence of rhegmatogenous retinal detachment in the Netherlands: Dutch Rhegmatogenous Retinal Detachment Study Group

Author

Van de Put MA, Hooymans, Jm, Los, Li, van den Biesen PR, Lindstedt, Ew, Van Meurs JC, Van Overdam KA, Veckeneer, Ma, Crama, N., Hoyng, Cb, Klevering, Bj, Theelen, T., Tilanus, Ma, Huiskamp, Ea, Nolte, Im, Postma, G., Renardel de Lavalette VW, Bijl, Hm, Lesnik-Oberstein, Sy, Marco Mura, Tan, Hs, Leeuwen, R., Schellekens, Pa, Stilma, Js, Bosscha, Mi, Reichert-Thoen, Jw, Ringens, Pj, De Vries-Knoppert WA, Goezinne, F., La Heij EC, Liem, Ta, Lundqvist, Ij, Kerkhoff, Ft, Van Oosterhout EJ, Rademaker, Rp, Busch, Em, Treskes, Dj, Feenstra, Rp, Buitendijk, Gh, Kiliç, E., Kuijpers, Rw, Vingerling, Jr, Swart, W., Gunning, Fp, Humalda, D., Hoppenreijs, Vp, Copper, Mn, and Rademakers, Aj

Subjects
NO
Published
2013

2. Effects of cyclic nucleotide analogs on intraocular pressure and trauma-induced inflammation in the rabbit eye.

Author

Busch MJ, van Oosterhout EJ, and Hoyng PF

Subjects
8-Bromo Cyclic Adenosine Monophosphate pharmacokinetics, Animals, Biological Transport, Active, Conjunctiva, Cyclic AMP metabolism, Cyclic GMP pharmacokinetics, Cyclic GMP pharmacology, Dinoprostone metabolism, Eye Diseases etiology, Eye Proteins metabolism, Inflammation metabolism, Rabbits, 8-Bromo Cyclic Adenosine Monophosphate pharmacology, Aqueous Humor metabolism, Corneal Injuries, Cyclic GMP analogs & derivatives, Eye Diseases metabolism, Intraocular Pressure drug effects
Abstract

In this study the effects of cell-permeable 8-bromo-cAMP and 8-bromo-cGMP on intraocular pressure (IOP) and puncture-induced inflammatory response were investigated. Both 8-bromo-cAMP and 8-Bromo-cGMP reduced IOP when given subconjunctivally, but not topically. Subconjunctival administration of 8-bromo-cAMP induced a moderate disruption of the blood-aqueous barrier (BAB); in addition, subconjunctival 8-bromo-cAMP, but not topical 8-bromo-cAMP or subconjunctival 8-bromo-cGMP, reduced the disruption of the BAB and elevation of the aqueous PGE2 level after puncture trauma. It is concluded that the effects of 8-bromo-cAMP depend on the mode of administration, since this determines the concentration of 8-bromo-cAMP reached in the aqueous humor. It is suggested that 8-bromo-cAMP can partially suppress a slight inflammatory response by interference with the release of arachidonic acid from the tissues surrounding the aqueous humor.

Published
1992
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results