5,983 results on '"Van Meter A"'
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2. Disti-Mator: an entanglement distillation-based state estimator
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Casapao, Joshua Carlo A., Maity, Ananda G., Benchasattabuse, Naphan, Hajdušek, Michal, Van Meter, Rodney, and Elkouss, David
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Quantum Physics - Abstract
Minimizing both experimental effort and consumption of valuable quantum resources in state estimation is vital in practical quantum information processing. Here, we explore characterizing states as an additional benefit of the entanglement distillation protocols. We show that the Bell-diagonal parameters of any undistilled state can be efficiently estimated solely from the measurement statistics of probabilistic distillation protocols. We further introduce the state estimator `Disti-Mator' designed specifically for a realistic experimental setting, and exhibit its robustness through numerical simulations. Our results demonstrate that a separate estimation protocol can be circumvented whenever distillation is an indispensable communication-based task., Comment: 14+5 pages, 5 figures, comments are welcome, repository link updated
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- 2024
3. Boosting end-to-end entanglement fidelity in quantum repeater networks via hybridized strategies
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Pathumsoot, Poramet, Tansuwannont, Theerapat, Benchasattabuse, Naphan, Satoh, Ryosuke, Hajdušek, Michal, Chaiwongkhot, Poompong, Suwanna, Sujin, and Van Meter, Rodney
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Quantum Physics ,Computer Science - Networking and Internet Architecture - Abstract
Quantum networks are expected to enhance distributed quantum computing and quantum communication over long distances while providing security dependent upon physical effects rather than mathematical assumptions. Through simulation, we show that a quantum network utilizing only entanglement purification or only quantum error correction as error management strategies cannot create Bell pairs with fidelity that exceeds the requirement for a secured quantum key distribution protocol for a broad range of hardware parameters. We propose hybrid strategies utilizing quantum error correction on top of purification and show that they can produce Bell pairs of sufficiently high fidelity. We identify the error parameter regime for gate and measurement errors in which these hybrid strategies are applicable., Comment: 8 pages, 3 figures, 1 table. This manuscript has been accepted for publication in the QCNC 2024 Conference Proceedings. The technical manuscript of this work is available at arXiv:2303.10295
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- 2024
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4. Scalable Timing Coordination of Bell State Analyzers in Quantum Networks
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Mori, Yoshihiro, Sasaki, Toshihiko, Ikuta, Rikizo, Teramoto, Kentaro, Ohno, Hiroyuki, Hajdušek, Michal, Van Meter, Rodney, and Nagayama, Shota
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Quantum Physics ,Computer Science - Networking and Internet Architecture - Abstract
The optical Bell State Analyzer (BSA) plays a key role in the optical generation of entanglement in quantum networks. The optical BSA is effective in controlling the timing of arriving photons to achieve interference. It is unclear whether timing synchronization is possible even in multi-hop and complex large-scale networks, and if so, how efficient it is. We investigate the scalability of BSA synchronization mechanisms over multiple hops for quantum networks both with and without memory in each node. We first focus on the exchange of entanglement between two network nodes via a BSA, especially effective methods of optical path coordination in achieving the simultaneous arrival of photons at the BSA. In optical memoryless quantum networks, including repeater graph state networks, we see that the quantum optical path coordination works well, though some possible timing coordination mechanisms have effects that cascade to adjacent links and beyond, some of which was not going to work well of timing coordination. We also discuss the effect of quantum memory, given that end-to-end extension of entangled states through multi-node entanglement exchange is essential for the practical application of quantum networks. Finally, cycles of all-optical links in the network topology are shown to may not be to synchronize, this property should be taken into account when considering synchronization in large networks., Comment: 7 pages, 9 figures. Submitted to the IEEE Quantum Week 2024
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- 2024
5. Engineering Challenges in All-photonic Quantum Repeaters
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Benchasattabuse, Naphan, Hajdušek, Michal, and Van Meter, Rodney
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Quantum Physics ,Computer Science - Networking and Internet Architecture - Abstract
Quantum networking, heralded as the next frontier in communication networks, envisions a realm where quantum computers and devices collaborate to unlock capabilities beyond what is possible with the Internet. A critical component for realizing a long-distance quantum network, and ultimately, the Quantum Internet, is the quantum repeater. As with the race to build a scalable quantum computer with different technologies, various schemes exist for building quantum repeaters. This article offers a gentle introduction to the two-way ``all-photonic quantum repeaters,'' a recent addition to quantum repeater technologies. In contrast to conventional approaches, these repeaters eliminate the need for quantum memories, offering the dual benefits of higher repetition rates and intrinsic tolerance to both quantum operational errors and photon losses. Using visualization and simple rules for manipulating graph states, we describe how all-photonic quantum repeaters work. We discuss the problem of the increased volume of classical communication required by this scheme, which places a huge processing requirement on the end nodes. We address this problem by presenting a solution that decreases the amount of classical communication by three orders of magnitude. We conclude by highlighting other key open challenges in translating the theoretical all-photonic framework into real-world implementation, providing insights into the practical considerations and future research directions of all-photonic quantum repeater technology., Comment: 9 pages, 4 figures, 2 tables; comments welcome!
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- 2024
6. Performance of Quantum Networks Using Heterogeneous Link Architectures
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Soon, Kento Samuel, Benchasattabuse, Naphan, Hajdušek, Michal, Teramoto, Kentaro, Nagayama, Shota, and Van Meter, Rodney
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Quantum Physics ,Computer Science - Networking and Internet Architecture - Abstract
The heterogeneity of quantum link architectures is an essential theme in designing quantum networks for technological interoperability and possibly performance optimization. However, the performance of heterogeneously connected quantum links has not yet been addressed. Here, we investigate the integration of two inherently different technologies, with one link where the photons flow from the nodes toward a device in the middle of the link, and a different link where pairs of photons flow from a device in the middle towards the nodes. We utilize the quantum internet simulator QuISP to conduct simulations. We first optimize the existing photon pair protocol for a single link by taking the pulse rate into account. Here, we find that increasing the pulse rate can actually decrease the overall performance. Using our optimized links, we demonstrate that heterogeneous networks actually work. Their performance is highly dependent on link configuration, but we observe no significant decrease in generation rate compared to homogeneous networks. This work provides insights into the phenomena we likely will observe when introducing technological heterogeneity into quantum networks, which is crucial for creating a scalable and robust quantum internetwork., Comment: 10 pages, 10 figures
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- 2024
7. Optimal Switching Networks for Paired-Egress Bell State Analyzer Pools
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Koyama, Marii, Yun, Claire, Taherkhani, Amin, Benchasattabuse, Naphan, Sane, Bernard Ousmane, Hajdušek, Michal, Nagayama, Shota, and Van Meter, Rodney
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Quantum Physics ,Computer Science - Networking and Internet Architecture - Abstract
To scale quantum computers to useful levels, we must build networks of quantum computational nodes that can share entanglement for use in distributed forms of quantum algorithms. In one proposed architecture, node-to-node entanglement is created when nodes emit photons entangled with stationary memories, with the photons routed through a switched interconnect to a shared pool of Bell state analyzers (BSAs). Designs that optimize switching circuits will reduce loss and crosstalk, raising entanglement rates and fidelity. We present optimal designs for switched interconnects constrained to planar layouts, appropriate for silicon waveguides and Mach-Zehnder interferometer (MZI) $2 \times 2$ switch points. The architectures for the optimal designs are scalable and algorithmically structured to pair any arbitrary inputs in a rearrangeable, non-blocking way. For pairing $N$ inputs, $N(N - 2)/4$ switches are required, which is less than half of number of switches required for full permutation switching networks. An efficient routing algorithm is also presented for each architecture. These designs can also be employed in reverse for entanglement generation using a shared pool of entangled paired photon sources., Comment: 11 pages, 8 figures, 1 table
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- 2024
8. An Implementation and Analysis of a Practical Quantum Link Architecture Utilizing Entangled Photon Sources
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Soon, Kento Samuel, Hajdušek, Michal, Nagayama, Shota, Benchasattabuse, Naphan, Teramoto, Kentaro, Satoh, Ryosuke, and Van Meter, Rodney
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Quantum Physics ,Computer Science - Networking and Internet Architecture - Abstract
Quantum repeater networks play a crucial role in distributing entanglement. Various link architectures have been proposed to facilitate the creation of Bell pairs between distant nodes, with entangled photon sources emerging as a primary technology for building quantum networks. Our work advances the Memory-Source-Memory (MSM) link architecture, addressing the absence of practical implementation details. We conduct numerical simulations using the Quantum Internet Simulation Package (QuISP) to analyze the performance of the MSM link and contrast it with other link architectures. We observe a saturation effect in the MSM link, where additional quantum resources do not affect the Bell pair generation rate of the link. By introducing a theoretical model, we explain the origin of this effect and characterize the parameter region where it occurs. Our work bridges theoretical insights with practical implementation, which is crucial for robust and scalable quantum networks., Comment: 8 pages, 8 figures
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- 2024
9. Parametrized Energy-Efficient Quantum Kernels for Network Service Fault Diagnosis
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Yamauchi, Hiroshi, Sogabe, Tomah, and Van Meter, Rodney
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Quantum Physics - Abstract
In quantum kernel learning, the primary method involves using a quantum computer to calculate the inner product between feature vectors, thereby obtaining a Gram matrix used as a kernel in machine learning models such as support vector machines (SVMs). However, a method for consistently achieving high performance has not been established. In this study, we investigate the diagnostic accuracy using a commercial dataset of a network service fault diagnosis system used by telecommunications carriers, focusing on quantum kernel learning, and propose a method to stably achieve high performance.We show significant performance improvements and an efficient achievement of high performance over conventional methods can be attained by applying quantum entanglement in the portion of the general quantum circuit used to create the quantum kernel, through input data parameter mapping and parameter tuning related to relative phase angles. Furthermore, experimental validation of the quantum kernel was conducted using IBM' s superconducting quantum computer IBM-Kawasaki, and its practicality was verified while applying the error suppression feature of Q-CTRL' s Fire Opal., Comment: Submitted to the IEEE International Conference on Quantum Computing and Engineering 2024
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- 2024
10. Entanglement Swapping in Orbit: a Satellite Quantum Link Case Study
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Fittipaldi, Paolo, Teramoto, Kentaro, Benchasattabuse, Naphan, Hajdušek, Michal, Van Meter, Rodney, and Grosshans, Frédéric
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Quantum Physics ,Computer Science - Networking and Internet Architecture - Abstract
Satellite quantum communication is a promising way to build long distance quantum links, making it an essential complement to optical fiber for quantum internetworking beyond metropolitan scales. A satellite point to point optical link differs from the more common fiber links in many ways, both quantitative (higher latency, strong losses) and qualitative (nonconstant parameter values during satellite passage, intermittency of the link, impossibility to set repeaters between the satellite and the ground station). We study here the performance of a quantum link between two ground stations, using a quantum-memory-equipped satellite as a quantum repeater. In contrast with quantum key distribution satellite links, the number of available quantum memory slots m, together with the unavoidable round-trip communication latency t of at least a few milliseconds, severely reduces the effective average repetition rate to m/t -- at most a few kilohertz for foreseeable quantum memories. Our study uses two approaches, which validate each other: 1) a simple analytical model of the effective rate of the quantum link; 2) an event-based simulation using the open source Quantum Internet Simulation Package (QuISP). The important differences between satellite and fiber links led us to modify QuISP itself. This work paves the way to the study of hybrid satellite- and fiber-based quantum repeater networks interconnecting different metropolitan areas., Comment: 7 pages, 6 figures. Accepted for presentation at the IEEE International Conference on Quantum Computing and Engineering 2024
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- 2024
11. Investigating the Impact of Learning Modality Shifts on K-12 Students' Physical Activity Participation During the COVID-19 Pandemic
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Chiara, Leanne, McDaniel, Alexander, Holland, William, Abel, Kirsten, Lothes, John, Morris, Laura, and Van Meter, Jessica
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Exercise ,Students ,Epidemics ,Distance education ,Physical fitness ,Education ,Sports and fitness - Abstract
The COVID-19 pandemic created many challenges for K-12 schools during the 2020-2021 school year (e.g, establishing social distancing measures, decisions regarding testing protocols, and transition from in-person to distance learning). Changes in teaching and learning modalities, from in-person to remote learning options, quickly became a reality for many students [an estimated 95%, according to Engzell et al. (2021)]. With an increase in distance learning came changes in students' structured and unstructured physical activity participation. The impact of these changes is unknown and justifies research investigating the effect modality shifts held on students' participation in physical activity and any associated outcomes. A mixed-methods survey was administered to examine changes in K-12 students' learning modality, participation in physical activity, and associated outcomes. Changes in learning modality from in-person to online were most frequently indicated (90%). Respondents stated both challenges and success stories associated with students' participation in physical activities resulting from modality shifts (e.g, decreased social engagements, decreased exposure to structured and facilitated physical education, and increased outdoor play). Positive outcomes were most prevalent in children engaging in moderate PA. However, 85% of respondents indicated a decrease in their child's physical activity participation. Our findings justify further investigation of the immediate and long-term impact of school modality shifts on students' engagement in physical activities., Introduction Throughout the 2020-2021 school year, the United States K-12 education system faced a breadth of challenges in providing students with an effective learning experience as a result of the [...]
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- 2024
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12. Noise estimation in an entanglement distillation protocol
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Maity, Ananda G., Casapao, Joshua C. A., Benchasattabuse, Naphan, Hajdušek, Michal, Van Meter, Rodney, and Elkouss, David
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Quantum Physics - Abstract
Estimating noise processes is an essential step for practical quantum information processing. Standard estimation tools require consuming valuable quantum resources. Here we ask the question of whether the noise affecting entangled states can be learned solely from the measurement statistics obtained during a distillation protocol. As a first step, we consider states of the Werner form and find that the Werner parameter can be estimated efficiently from the measurement statistics of an idealized distillation protocol. Our proposed estimation method can find application in scenarios where distillation is an unavoidable step., Comment: 3 pages, 1 figures, Proceedings of Quantum Systems and Computation Workshop in conjunction with ACM Sigmetrics (2023)
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- 2024
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13. ORP Gym: Online Oral Repetition Practice Support System for Large-scale Japanese-Speaking Courses Abroad
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Kataoka, Yuka, Thamrin, Achmad Husni, and Van Meter, Rodney
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- 2024
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14. The Role of Axillary Lymph Node Dissection versus Sentinel Lymph Node Dissection in Breast Cancer Patients with Clinical N2b–N3c Disease Who Receive Adjuvant Radiotherapy
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Roach, Eric A., Weil, Christopher R., Cannon, George, Grant, Jon, Van Meter, Margaret, and Boothe, Dustin
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- 2024
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15. Psychosocial Interventions: A Key Component in an Evidence-Based Treatment Approach to Bipolar Disorder
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Knowles, Ellen A., Schneier, Lauren Gorelick, Yang, Lauren A., and Van Meter, Anna R.
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- 2024
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16. Testing and Debugging Quantum Circuits
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Metwalli, Sara Ayman and Van Meter, Rodney
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Quantum Physics - Abstract
This paper introduces a process framework for debugging quantum circuits, focusing on three distinct types of circuit blocks: Amplitude Permutation, Phase Modulation, and Amplitude Redistribution circuit blocks. Our research addresses the critical need for specialized debugging approaches tailored to the unique properties of each circuit type. For Amplitude Permutation Circuits, we propose techniques to correct amplitude permutations mimicking classical operations. In phase modulation circuits, our proposed strategy targets the precise calibration of phase alterations essential for quantum computations. The most complex Amplitude Redistribution Circuits demand advanced methods to adjust probability amplitudes. This research bridges a vital gap in current methodologies and lays the groundwork for future advancements in quantum circuit debugging. Our contributions are twofold: We present a comprehensive unit testing tool (Cirquo) and debugging approaches tailored to the unique demands of quantum computing, and we provide empirical evidence of its effectiveness in optimizing quantum circuit performance. This work is a crucial step toward realizing robust quantum computing systems and their applications in various domains.
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- 2023
17. The geometry of flow: Advancing predictions of river geometry with multi-model machine learning
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Chang, Shuyu Y, Ghahremani, Zahra, Manuel, Laura, Erfani, Mohammad, Shen, Chaopeng, Cohen, Sagy, Van Meter, Kimberly, Pierce, Jennifer L, Meselhe, Ehab A, and Goharian, Erfan
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Physics - Geophysics ,Computer Science - Machine Learning - Abstract
Hydraulic geometry parameters describing river hydrogeomorphic is important for flood forecasting. Although well-established, power-law hydraulic geometry curves have been widely used to understand riverine systems and mapping flooding inundation worldwide for the past 70 years, we have become increasingly aware of the limitations of these approaches. In the present study, we have moved beyond these traditional power-law relationships for river geometry, testing the ability of machine-learning models to provide improved predictions of river width and depth. For this work, we have used an unprecedentedly large river measurement dataset (HYDRoSWOT) as well as a suite of watershed predictor data to develop novel data-driven approaches to better estimate river geometries over the contiguous United States (CONUS). Our Random Forest, XGBoost, and neural network models out-performed the traditional, regionalized power law-based hydraulic geometry equations for both width and depth, providing R-squared values of as high as 0.75 for width and as high as 0.67 for depth, compared with R-squared values of 0.57 for width and 0.18 for depth from the regional hydraulic geometry equations. Our results also show diverse performance outcomes across stream orders and geographical regions for the different machine-learning models, demonstrating the value of using multi-model approaches to maximize the predictability of river geometry. The developed models have been used to create the newly publicly available STREAM-geo dataset, which provides river width, depth, width/depth ratio, and river and stream surface area (%RSSA) for nearly 2.7 million NHDPlus stream reaches across the rivers and streams across the contiguous US., Comment: 30 pages, 10 figures
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- 2023
18. Quantum Communications
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Hajdušek, Michal and Van Meter, Rodney
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Quantum Physics - Abstract
The second quantum revolution has been picking up momentum over the last decade. Quantum technologies are starting to attract more attention from governments, private companies, investors, and public. The ability to control individual quantum systems for the purpose of information processing and communication is no longer a theoretical dream, but is steadily becoming routine in laboratories and startups around the world. With this comes the need to educate the future generation of quantum engineers. This textbook is a companion to our video lectures on Overview of Quantum Communications from the Q-Leap Education project known as Quantum Academy of Science and Technology. It is a gentle introduction to quantum networks, and is suitable for use as a textbook for undergraduate students of diverse background. No prior knowledge of quantum physics or quantum information is assumed. Exercises are included in each chapter., Comment: 308 pages, still an early draft, all comments are welcome!
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- 2023
19. The Impact of the School Learning Environment on Student Academic Achievement from the School Employees' Perspective
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Sheena R. Van Meter
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The purpose of this research was to examine the impact that school learning environment has on student achievement from the perspective of the school employees. The research was carried out using a mixed methods approach, evaluating historical data to determine relationships between school learning environment and student achievement in two rural schools in West Virginia. Current research indicates that a supportive school learning environment influences school success and effectiveness positively (Hattie, 2008). While school culture is identified in various ways throughout the research, the definitions repeatedly align and generally describe the school culture using a combination of the following terms: beliefs, norms, habits, customs, traditions, attitudes, relationships and behaviors within a school (Bayar, 2021) (Atasoy, 2020). While some research seems to indicate that a students' homelife and socioeconomic status contribute to their level of academic achievement (Bradley, 2022), additional research indicates that the schools hold the responsibility of student success in a variety of ways, including positive relationships and a supportive school learning environment (Sack-Min, 2018). The intentions of this study were to contribute to research in identifying the relationship between school learning environment and student achievement as well as to answer the question, "Does the perception of the school learning environment from the perspective of the school employees impact student achievement?" Identifying contributors to increased student achievement will be beneficial to school districts that are trying to improve student learning outcomes. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]
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- 2024
20. Fight or Flight: Cosmic Ray-Induced Phonons and the Quantum Surface Code
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Sane, Bernard Ousmane, Van Meter, Rodney, and Hajdušek, Michal
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Quantum Physics - Abstract
Recent work has identified cosmic ray events as an error source limiting the lifetime of quantum data. These errors are correlated and affect a large number of qubits, leading to the loss of data across a quantum chip. Previous works attempting to address the problem in hardware or by building distributed systems still have limitations. We approach the problem from a different perspective, developing a new hybrid hardware-software-based strategy based on the 2-D surface code, assuming the parallel development of a hardware strategy that limits the phonon propagation radius. We propose to flee the area: move the logical qubits far enough away from the strike's epicenter to maintain our logical information. Specifically, we: (1) establish the minimum hardware requirements needed for our approach; (2) propose a mapping for moving logical qubits; and (3) evaluate the possible choice of the code distance. Our analysis considers two possible cosmic ray events: those far from both ``holes'' in the surface code and those near or overlapping a hole. We show that the probability that the logical qubit will be destroyed can be reduced from 100% to the range 4% to 15% depending on the time required to move the logical qubit.
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- 2023
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21. A Substrate Scheduler for Compiling Arbitrary Fault-tolerant Graph States
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Liu, Sitong, Benchasattabuse, Naphan, Morgan, Darcy QC, Hajdušek, Michal, Devitt, Simon J., and Van Meter, Rodney
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Quantum Physics - Abstract
Graph states are useful computational resources in quantum computing, particularly in measurement-based quantum computing models. However, compiling arbitrary graph states into executable form for fault-tolerant surface code execution and accurately estimating the compilation cost and the run-time resource cost remains an open problem. We introduce the Substrate Scheduler, a compiler module designed for fault-tolerant graph state compilation. The Substrate Scheduler aims to minimize the space-time volume cost of generating graph states. We show that Substrate Scheduler can efficiently compile graph states with thousands of vertices for "A Game of Surface Codes"-style patch-based surface code systems. Our results show that our module generates graph states with the lowest execution time complexity to date, achieving graph state generation time complexity that is at or below linear in the number of vertices and demonstrating specific types of graphs to have constant generation time complexity. Moreover, it provides a solid foundation for developing compilers that can handle a larger number of vertices, up to the millions or billions needed to accommodate a wide range of post-classical quantum computing applications., Comment: 11 pages, 11 figures
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- 2023
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22. Architecture and protocols for all-photonic quantum repeaters
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Benchasattabuse, Naphan, Hajdušek, Michal, and Van Meter, Rodney
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Quantum Physics ,Computer Science - Networking and Internet Architecture - Abstract
The all-photonic quantum repeater scheme, utilizing a type of graph state called the repeater graph state (RGS), promises resilience to photon losses and operational errors, offering a fast Bell pair generation rate limited only by the RGS creation time (rather than enforced round-trip waits). While existing research has predominantly focused on RGS generation and secret key sharing rate analysis, there is a need to extend investigations to encompass broader applications, such as distributed computation and teleportation, the main tasks envisioned for the Quantum Internet. Here we propose a new emitter-photonic qubit building block and an RGS protocol that addresses several key considerations: end node involvement in connection establishment, decoding of logical qubits within the RGS, and computing the Pauli frame corrections at each participating node to ensure the desired correct end-to-end Bell pair state. Our proposed building block significantly reduces the total number of emissive quantum memories required for end nodes and seamlessly integrates all-photonic and memory-based repeaters under the same communication protocol. We also present an algorithm for decoding logical measurement results, employing graphical reasoning based on graph state manipulation rules., Comment: 11 pages, 7 figures, (improve protocol details); comments welcome!
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- 2023
23. ASO Visual Abstract: The Role of Axillary Lymph Node Dissection Versus Sentinel Lymph Node Dissection in Breast Cancer Patients with Clinical N2b-N3c Disease Who Receive Adjuvant Radiotherapy
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Roach, Eric A., Weil, Christopher R., Cannon, George, Grant, Jon, Van Meter, Margaret, and Boothe, Dustin
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- 2024
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24. Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure
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Vriend, Chris, de Joode, Niels T., Pouwels, Petra J. W., Liu, Feng, Otaduy, Maria C. G., Pastorello, Bruno, Robertson, Frances C., Ipser, Jonathan, Lee, Seonjoo, Hezel, Dianne M., van Meter, Page E., Batistuzzo, Marcelo C., Hoexter, Marcelo Q., Sheshachala, Karthik, Narayanaswamy, Janardhanan C., Venkatasubramanian, Ganesan, Lochner, Christine, Miguel, Euripedes C., Reddy, Y. C. Janardhan, Shavitt, Roseli G., Stein, Dan J., Wall, Melanie, Simpson, Helen Blair, and van den Heuvel, Odile A.
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- 2024
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25. The stability and persistence of symptoms in childhood-onset ADHD
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Van Meter, Anna R., Sibley, Margaret H., Vandana, Pankhuree, Birmaher, Boris, Fristad, Mary A., Horwitz, Sarah, Youngstrom, Eric A., Findling, Robert L., and Arnold, L. Eugene
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- 2024
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26. Digital quantum simulator for the time-dependent Dirac equation using discrete-time quantum walks
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Miyashita, Shigetora, Satoh, Takahiko, Sugawara, Michihiko, Benchasattabuse, Naphan, Nakanishi, Ken M., Hajdušek, Michal, Choi, Hyensoo, and Van Meter, Rodney
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Quantum Physics - Abstract
We introduce a quantum algorithm for simulating the time-dependent Dirac equation in 3+1 dimensions using discrete-time quantum walks. Thus far, promising quantum algorithms have been proposed to simulate quantum dynamics in non-relativistic regimes efficiently. However, only some studies have attempted to simulate relativistic dynamics due to its theoretical and computational difficulty. By leveraging the convergence of discrete-time quantum walks to the Dirac equation, we develop a quantum spectral method that approximates smooth solutions with exponential convergence. This mitigates errors in implementing potential functions and reduces the overall gate complexity that depends on errors. We demonstrate that our approach does not require additional operations compared to the asymptotic gate complexity of non-relativistic real-space algorithms. Our findings indicate that simulating relativistic dynamics is achievable with quantum computers and can provide insights into relativistic quantum physics and chemistry., Comment: 11 pages, 5 figures
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- 2023
27. Hybrid Error-Management Strategies in Quantum Repeater Networks
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Pathumsoot, Poramet, Tansuwannont, Theerapat, Benchasattabuse, Naphan, Satoh, Ryosuke, Hajdušek, Michal, Chaiwongkhot, Poompong, Suwanna, Sujin, and Van Meter, Rodney
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Quantum Physics - Abstract
A quantum network is expected to enhance distributed quantum computing and quantum communication over a long distance while providing unconditional security. As quantum entanglement is essential for a quantum network, major issues from various types of noise and decoherence prevent it from being realized, and research has been intensively active to obtain optimal configurations for a quantum network. In this work, we address the performance of a quantum network capable of quantum error correction and entanglement purification. Our results show that one should distribute Bell pairs as fast as possible while balancing the deployment of fidelity enhancement. We also show suitable hybrid strategies in quantum cryptography tasks under some noise regimes that need to use purification and quantum error correction together. Our results suggest that using purification to distribute high fidelity Bell pairs and preserving them for application using quantum error correction is a promising way to achieve a near-term quantum network for secure communication., Comment: 22 pages, 7 figures
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- 2023
28. Leveraging hardware-control imperfections for error mitigation via generalized quantum subspace
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Ohkura, Yasuhiro, Endo, Suguru, Satoh, Takahiko, Van Meter, Rodney, and Yoshioka, Nobuyuki
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Quantum Physics - Abstract
In the era of quantum computing without full fault-tolerance, it is essential to suppress noise effects via the quantum error mitigation techniques to enhance the computational power of the quantum devices. One of the most effective noise-agnostic error mitigation schemes is the generalized quantum subspace expansion (GSE) method, which unifies various mitigation algorithms under the framework of the quantum subspace expansion. Specifically, the fault-subspace method, a subclass of GSE method, constructs an error-mitigated quantum state with copies of quantum states with different noise levels. However, from the experimental aspect, it is nontrivial to determine how to reliably amplify the noise so that the error in the simulation result is efficiently suppressed. In this work, we explore the potential of the fault-subspace method by leveraging the hardware-oriented noise: intentional amplification of the decoherence, noise boost by insertion of identity, making use of crosstalk, and probabilistic implementation of noise channel. We demonstrate the validity of our proposals via both numerical simulations with the noise parameters reflecting those in quantum devices available via IBM Quantum, and also experiments performed therein., Comment: 11 pages, 10 figures
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- 2023
29. Hyperbaric oxygen therapy in the ATLS/ACLS resuscitative management of acutely ill or severely injured patients with severe anemia: a review
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Keith W. Van Meter
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anemia ,normobaric oxygen ,hyperbaric oxygen ,adenosine triphosphate ,advanced cardiac life support ,advanced trauma life support ,Medicine (General) ,R5-920 - Abstract
For short periods, even without the presence of red blood cells, hyperbaric oxygen can safely allow plasma to meet the oxygen delivery requirements of a human at rest. By this means, hyperbaric oxygen, in special instances, may be used as a bridge to lessen blood transfusion requirements. Hyperbaric oxygen, applied intermittently, can readily avert oxygen toxicity while meeting the body's oxygen requirements. In acute injury or illness, accumulated oxygen debt is shadowed by adenosine triphosphate debt. Hyperbaric oxygen efficiently provides superior diffusion distances of oxygen in tissue compared to those provided by breathing normobaric oxygen. Intermittent application of hyperbaric oxygen can resupply adenosine triphosphate for energy for gene expression and reparative and anti-inflammatory cellular function. This advantageous effect is termed the hyperbaric oxygen paradox. Similarly, the normobaric oxygen paradox has been used to elicit erythropoietin expression. Referfusion injury after an ischemic insult can be ameliorated by hyperbaric oxygen administration. Oxygen toxicity can be averted by short hyperbaric oxygen exposure times with air breaks during treatments and also by lengthening the time between hyperbaric oxygen sessions as the treatment advances. Hyperbaric chambers can be assembled to provide everything available to a patient in modern-day intensive care units. The complication rate of hyperbaric oxygen therapy is very low. Accordingly, hyperbaric oxygen, when safely available in hospital settings, should be considered as an adjunct for the management of critically injured or ill patients with disabling anemia.
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- 2024
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30. Exploring Opportunities to Augment Psychotherapy with Language Models.
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Yuewen Yang, Thalia Viranda, Anna R. Van Meter, Tanzeem Choudhury, and Daniel A. Adler
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- 2024
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31. A Tool For Debugging Quantum Circuits
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Metwalli, Sara Ayman and Van Meter, Rodney
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Quantum Physics - Abstract
As the scale of quantum programs grows to match that of classical software, the nascent field of quantum software engineering must mature and tools such as debuggers will become increasingly important. However, developing a quantum debugger is challenging due to the nature of a quantum computer; sneaking a peek at the value of a quantum state will cause either partial or complete collapse of the superposition and may destroy the necessary entanglement. As a first step to developing a full quantum circuit debugger, we have designed and implemented a quantum circuit debugging tool. The tool allows the user to divide the circuit vertically or horizontally into smaller chunks known as slices, and manage their simulation or execution for either interactive debugging or automated testing. The tool also enables developers to track gates within the overall circuit and each chunk to understand their behavior better. Feedback on usefulness and usability from early users shows that using the tool to slice and test their circuits has helped make the debugging process more time-efficient for them.
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- 2022
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32. Amplitude Amplification for Optimization via Subdivided Phase Oracle
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Benchasattabuse, Naphan, Satoh, Takahiko, Hajdušek, Michal, and Van Meter, Rodney
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Quantum Physics - Abstract
We propose an algorithm using a modified variant of amplitude amplification to solve combinatorial optimization problems via the use of a subdivided phase oracle. Instead of dividing input states into two groups and shifting the phase equally for all states within the same group, the subdivided phase oracle changes the phase of each input state uniquely in proportion to their objective value. We provide visualization of how amplitudes change after each iteration of applying the subdivided phase oracle followed by conventional Grover diffusion in the complex plane. We then show via numerical simulation that for normal, skew normal, and exponential distribution of objective values, the algorithm can be used to amplify the probability of measuring the optimal solution to a significant degree independent of the search space size. In the case of skew normal and exponential distributions, this probability can be amplified to be close to unity, making our algorithm near deterministic. We then modify our algorithm in order to demonstrate how it can be extended to a broader set of objective value distributions. Finally, we discuss the speedup compared to classical schemes using the query complexity model, and show that our algorithm offers a significant advantage over these classical approaches., Comment: 9 pages, 7 figures, comments welcome
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- 2022
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33. Distributed quantum error correction for chip-level catastrophic errors
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Xu, Qian, Seif, Alireza, Yan, Haoxiong, Mannucci, Nam, Sane, Bernard Ousmane, Van Meter, Rodney, Cleland, Andrew N., and Jiang, Liang
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Quantum Physics - Abstract
Quantum error correction holds the key to scaling up quantum computers. Cosmic ray events severely impact the operation of a quantum computer by causing chip-level catastrophic errors, essentially erasing the information encoded in a chip. Here, we present a distributed error correction scheme to combat the devastating effect of such events by introducing an additional layer of quantum erasure error correcting code across separate chips. We show that our scheme is fault tolerant against chip-level catastrophic errors and discuss its experimental implementation using superconducting qubits with microwave links. Our analysis shows that in state-of-the-art experiments, it is possible to suppress the rate of these errors from 1 per 10 seconds to less than 1 per month.
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- 2022
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34. A Multicenter Home-based Prehabilitation Intervention in Kidney Transplant Candidates
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Lorenz, Elizabeth C., Bonikowske, Amanda R., David-Van Meter, Ashley C., Munson, Cortney L., Roschen, Callie A., Salstrand, Rosalyn M., Wolter, Anne D., Murthy, Bhamidipati V., Davis, LaShara A., Choi, Namkee G., and Kennedy, Cassie C.
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- 2024
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35. Failure of human rhombic lip differentiation underlies medulloblastoma formation
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Hendrikse, Liam D, Haldipur, Parthiv, Saulnier, Olivier, Millman, Jake, Sjoboen, Alexandria H, Erickson, Anders W, Ong, Winnie, Gordon, Victor, Coudière-Morrison, Ludivine, Mercier, Audrey L, Shokouhian, Mohammad, Suárez, Raúl A, Ly, Michelle, Borlase, Stephanie, Scott, David S, Vladoiu, Maria C, Farooq, Hamza, Sirbu, Olga, Nakashima, Takuma, Nambu, Shohei, Funakoshi, Yusuke, Bahcheli, Alec, Diaz-Mejia, J Javier, Golser, Joseph, Bach, Kathleen, Phuong-Bao, Tram, Skowron, Patryk, Wang, Evan Y, Kumar, Sachin A, Balin, Polina, Visvanathan, Abhirami, Lee, John JY, Ayoub, Ramy, Chen, Xin, Chen, Xiaodi, Mungall, Karen L, Luu, Betty, Bérubé, Pierre, Wang, Yu C, Pfister, Stefan M, Kim, Seung-Ki, Delattre, Olivier, Bourdeaut, Franck, Doz, François, Masliah-Planchon, Julien, Grajkowska, Wieslawa A, Loukides, James, Dirks, Peter, Fèvre-Montange, Michelle, Jouvet, Anne, French, Pim J, Kros, Johan M, Zitterbart, Karel, Bailey, Swneke D, Eberhart, Charles G, Rao, Amulya AN, Giannini, Caterina, Olson, James M, Garami, Miklós, Hauser, Peter, Phillips, Joanna J, Ra, Young S, de Torres, Carmen, Mora, Jaume, Li, Kay KW, Ng, Ho-Keung, Poon, Wai S, Pollack, Ian F, López-Aguilar, Enrique, Gillespie, G Yancey, Van Meter, Timothy E, Shofuda, Tomoko, Vibhakar, Rajeev, Thompson, Reid C, Cooper, Michael K, Rubin, Joshua B, Kumabe, Toshihiro, Jung, Shin, Lach, Boleslaw, Iolascon, Achille, Ferrucci, Veronica, de Antonellis, Pasqualino, Zollo, Massimo, Cinalli, Giuseppe, Robinson, Shenandoah, Stearns, Duncan S, Van Meir, Erwin G, Porrati, Paola, Finocchiaro, Gaetano, Massimino, Maura, Carlotti, Carlos G, Faria, Claudia C, Roussel, Martine F, Boop, Frederick, Chan, Jennifer A, Aldinger, Kimberly A, Razavi, Ferechte, Silvestri, Evelina, McLendon, Roger E, and Thompson, Eric M
- Subjects
Stem Cell Research ,Brain Disorders ,Neurosciences ,Rare Diseases ,Stem Cell Research - Nonembryonic - Non-Human ,Aetiology ,1.1 Normal biological development and functioning ,Underpinning research ,2.1 Biological and endogenous factors ,Cell Differentiation ,Cell Lineage ,Cerebellar Neoplasms ,Cerebellum ,Core Binding Factor alpha Subunits ,Hedgehog Proteins ,Histone Demethylases ,Humans ,Ki-67 Antigen ,Medulloblastoma ,Metencephalon ,Muscle Proteins ,Mutation ,Otx Transcription Factors ,Repressor Proteins ,T-Box Domain Proteins ,Transcription Factors ,General Science & Technology - Abstract
Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal neoplasms of the hindbrain with strong links to early development of the hindbrain1-4. Mutations that activate Sonic hedgehog signalling lead to Sonic hedgehog MB in the upper rhombic lip (RL) granule cell lineage5-8. By contrast, mutations that activate WNT signalling lead to WNT MB in the lower RL9,10. However, little is known about the more commonly occurring group 4 (G4) MB, which is thought to arise in the unipolar brush cell lineage3,4. Here we demonstrate that somatic mutations that cause G4 MB converge on the core binding factor alpha (CBFA) complex and mutually exclusive alterations that affect CBFA2T2, CBFA2T3, PRDM6, UTX and OTX2. CBFA2T2 is expressed early in the progenitor cells of the cerebellar RL subventricular zone in Homo sapiens, and G4 MB transcriptionally resembles these progenitors but are stalled in developmental time. Knockdown of OTX2 in model systems relieves this differentiation blockade, which allows MB cells to spontaneously proceed along normal developmental differentiation trajectories. The specific nature of the split human RL, which is destined to generate most of the neurons in the human brain, and its high level of susceptible EOMES+KI67+ unipolar brush cell progenitor cells probably predisposes our species to the development of G4 MB.
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- 2022
36. Postoperative pain scores and opioid use after standard bupivacaine vs. liposomal bupivacaine regional blocks for abdominal cancer surgery: A propensity score matched study
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Boyev, Artem, Popat, Keyuri, Gottumukkala, Vijaya N.R., Kwater, Andrzej P., Chiang, Yi-Ju, Prakash, Laura R., Newhook, Timothy E., Arvide, Elsa M., Dewhurst, Whitney L., Bruno, Morgan L., Van Meter, Antoinette, Hancher-Hodges, Shannon, Ghebremichael, Semhar, Williams, Uduak, Donahue, Hart, Soliz, Jose, and Tzeng, Ching-Wei D.
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- 2024
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37. Does mood affect judgment: Results from an in vivo observational study
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Chao, Michelle, Koay, Jun Min, and Van Meter, Anna
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Psychological research ,Judgment -- Research ,Mood (Psychology) -- Influence ,Psychology and mental health - Abstract
Previous research has examined how mood affects individuals' judgment. Our study aims to extend this research to evaluate the influence of mood on judgment in vivo. Using a smartphone-based design, we prompted participants (N = 103) three times a day to rate their mood and perform one of three judgment tasks three times a day for one week: (1) evaluate their self-efficacy on a word unscrambling task, (2) identify face emotions, or (3) judge risk by pumping virtual balloons. Our results showed that, contrary to our hypotheses, mood did not have a significant effect on the judgments individuals made. Prior task performance and task trial were significant predictors of self-efficacy; sex and task trial were associated with face emotion recognition; and balloons popped the day prior, and task trial influenced how individuals evaluated risk. The in vivo design of this study is a novel and more ecologically valid than some earlier work, but it is not without limitations, including the self-reported nature of mood, and potential for unmeasured third variable effects. This research raises questions about the validity of lab-based studies of the relation between mood and judgment, and shows the capacity of in vivo research and technology to challenge and enhance our understanding of how mood influences behavior., Author(s): Michelle Chao [sup.1] [sup.2] , Jun Min Koay [sup.1] [sup.3] , Anna Van Meter [sup.1] [sup.4] Author Affiliations: (1) grid.268433.8, 0000 0004 1936 7638, Ferkauf Graduate School of Psychology, [...]
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- 2023
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38. Testing and Debugging Quantum Circuits
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Sara Ayman Metwalli and Rodney Van Meter
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Debugging ,quantum programs ,quantum software ,testing ,Atomic physics. Constitution and properties of matter ,QC170-197 ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
This article introduces a process framework for debugging quantum circuits, focusing on three distinct types of circuit blocks: amplitude–permutation, phase-modulation, and amplitude–redistribution circuit blocks. Our research addresses the critical need for specialized debugging approaches tailored to the unique properties of each circuit type. For amplitude–permutation circuits, we propose techniques to correct amplitude–permutations mimicking classical operations. In phase-modulation circuits, our proposed strategy targets the precise calibration of phase alterations essential for quantum computations. The most complex amplitude–redistribution circuits demand advanced methods to adjust probability amplitudes. This research bridges a vital gap in current methodologies and lays the groundwork for future advancements in quantum circuit debugging. Our contributions are twofold: we present a comprehensive unit testing tool (Cirquo) and debugging approaches tailored to the unique demands of quantum computing, and we provide empirical evidence of its effectiveness in optimizing quantum circuit performance. This work is a crucial step toward realizing robust quantum computing systems and their applications in various domains.
- Published
- 2024
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39. Widespread increases in soluble phosphorus concentrations in streams across the transboundary Great Lakes Basin
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Singh, Nitin K., Van Meter, Kimberly J., and Basu, Nandita B.
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- 2023
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40. QuISP: a Quantum Internet Simulation Package
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Satoh, Ryosuke, Hajdušek, Michal, Benchasattabuse, Naphan, Nagayama, Shota, Teramoto, Kentaro, Matsuo, Takaaki, Metwalli, Sara Ayman, Satoh, Takahiko, Suzuki, Shigeya, and Van Meter, Rodney
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Quantum Physics ,Computer Science - Networking and Internet Architecture ,Computer Science - Software Engineering - Abstract
We present an event-driven simulation package called QuISP for large-scale quantum networks built on top of the OMNeT++ discrete event simulation framework. Although the behavior of quantum networking devices have been revealed by recent research, it is still an open question how they will work in networks of a practical size. QuISP is designed to simulate large-scale quantum networks to investigate their behavior under realistic, noisy and heterogeneous configurations. The protocol architecture we propose enables studies of different choices for error management and other key decisions. Our confidence in the simulator is supported by comparing its output to analytic results for a small network. A key reason for simulation is to look for emergent behavior when large numbers of individually characterized devices are combined. QuISP can handle thousands of qubits in dozens of nodes on a laptop computer, preparing for full Quantum Internet simulation. This simulator promotes the development of protocols for larger and more complex quantum networks., Comment: 17 pages, 12 figures
- Published
- 2021
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41. A Quantum Internet Architecture
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Van Meter, Rodney, Satoh, Ryosuke, Benchasattabuse, Naphan, Matsuo, Takaaki, Hajdušek, Michal, Satoh, Takahiko, Nagayama, Shota, and Suzuki, Shigeya
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Quantum Physics ,Computer Science - Networking and Internet Architecture - Abstract
Entangled quantum communication is advancing rapidly, with laboratory and metropolitan testbeds under development, but to date there is no unifying Quantum Internet architecture. We propose a Quantum Internet architecture centered around the Quantum Recursive Network Architecture (QRNA), using RuleSet-based connections established using a two-pass connection setup. Scalability and internetworking (for both technological and administrative boundaries) are achieved using recursion in naming and connection control. In the near term, this architecture will support end-to-end, two-party entanglement on minimal hardware, and it will extend smoothly to multi-party entanglement and the use of quantum error correction on advanced hardware in the future. For a network internal gateway protocol, we recommend (but do not require) qDijkstra with seconds per Bell pair as link cost for routing; the external gateway protocol is designed to build recursively. The strength of our architecture is shown by assessing extensibility and demonstrating how robust protocol operation can be confirmed using the RuleSet paradigm., Comment: 17 pages, 7 numbered figures
- Published
- 2021
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42. Simultaneous execution of quantum circuits on current and near-future NISQ systems
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Ohkura, Yasuhiro, Satoh, Takahiko, and Van Meter, Rodney
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Quantum Physics - Abstract
In the NISQ era, multi-programming of quantum circuits (QC) helps to improve the throughput of quantum computation. Although the crosstalk, which is a major source of noise on NISQ processors, may cause performance degradation of concurrent execution of multiple QCs, its characterization cost grows quadratically in processor size. To address these challenges, we introduce palloq (parallel allocation of QCs) for improving the performance of quantum multi-programming on NISQ processors while paying attention to the combination of QCs in parallel execution and their layout on the quantum processor, and reducing unwanted interference between QCs caused by crosstalk. We also propose a software-based crosstalk detection protocol that efficiently and successfully characterizes the hardware's suitability for multi-programming. We found a trade-off between the success rate and execution time of the multi-programming. This would be attractive not only to quantum computer service but also to users around the world who want to run algorithms of suitable scale on NISQ processors that have recently attracted great attention and are being enthusiastically investigated., Comment: 10 pages, 10 figures
- Published
- 2021
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43. Decadal changes in microplastic accumulation in freshwater sediments: Evaluating influencing factors
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Bussarakum, Jutamas, Burgos, William D., Cohen, Samuel B., Van Meter, Kimberly, Sweetman, Jon N., Drohan, Patrick J., Najjar, Raymond G., Arriola, Jill M., Pankratz, Katharina, Emili, Lisa A., and Warner, Nathaniel R.
- Published
- 2024
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44. Understanding the financial aspects of digital pathology: A dynamic customizable return on investment calculator for informed decision-making
- Author
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Ardon, Orly, Asa, Sylvia L., Lloyd, Mark C., Lujan, Giovanni, Parwani, Anil, Santa-Rosario, Juan C., Van Meter, Bryan, Samboy, Jennifer, Pirain, Danielle, Blakely, Scott, and Hanna, Matthew G.
- Published
- 2024
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45. Investigating the Effect of Computer-Mediated Feedback via an LMS Integration in a Large-Scale Japanese Speaking Class
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Kataoka, Yuka, Thamrin, Achmad Husni, Van Meter, Rodney, Murai, Jun, and Kataoka, Kotaro
- Abstract
In second or foreign language (SFL) education, oral corrective feedback (OCF) is widely used to individually correct students' erroneous utterances during classroom hours. However, students cannot have sufficient opportunities for oral production and personalized feedback during classroom hours if a class is large-scale with many students. This paper addresses the lack of OCF opportunities in a large-scale class, assuming the causes to be the severe time constraints and the teachers' labor intensiveness in examining students' utterances and generating OCF. This research proposes using computer-mediated feedback (CMF) outside classroom hours to complement OCF in an online, semiautomated, and scalable fashion. This paper implements Oral Repetition Practice (ORP) Gym to provide students with sufficient opportunities for speaking practice through two types of CMFs; Hybrid Recast to enhance the recognition of errors and Explicit Error Correction to make errors detectable and correctable. Online External Assistant (OEA) is a mechanism used to increase the amount and quality of feedback by distributing the workload for scoring and generating CMF. The evaluation was conducted as a classroom observational study by introducing ORP Gym to a spoken Japanese SFL basics course with 55 students at an Indian university. Compared with the students who did not utilize ORP Gym, those who utilized ORP Gym performed more ORP and exhibited significant score improvement in the posttest. This research contributes to enabling CMF in large-scale SFL classes and empirically and statistically proving the improvement of the learning effect, including uptake and repair, by CMF using ORP Gym and an OEA.
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- 2023
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46. Commentary: Measurement and the Study of Motivation and Strategy Use--Determining If and When Self-Report Measures Are Appropriate
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Van Meter, Peggy N.
- Abstract
The goal of this special issue is to examine the use of self-report measures in the study of motivation and strategy use. This commentary reviews the articles contained in this special issue to address the primary objective of determining if and when self-report measures contribute to understanding these major constructs involved in self-regulated learning. Guided by three central questions, this review highlights some of the major, emergent themes regarding the use of self-report. The issues addressed include attention to evidence for construct validity, the need to consider broad methodological factors in the collection and interpretation of self-report data, and the innovations made possible by modern tools for administering and analyzing self-report measures. Conclusions forward a set of conditions for the use of self-report measures, which center on the role of theoretically-driven choices in both the selection of self-report measures and analysis of the data these measures generate.
- Published
- 2020
47. The Present and Future of Discrete Logarithm Problems on Noisy Quantum Computers
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Aono, Yoshinori, Liu, Sitong, Tanaka, Tomoki, Uno, Shumpei, Van Meter, Rodney, Shinohara, Naoyuki, and Nojima, Ryo
- Subjects
Computer Science - Cryptography and Security ,Quantum Physics - Abstract
The discrete logarithm problem (DLP) is the basis for several cryptographic primitives. Since Shor's work, it has been known that the DLP can be solved by combining a polynomial-size quantum circuit and a polynomial-time classical post-processing algorithm. Evaluating and predicting the instance size that quantum devices can solve is an emerging research topic. In this paper, we propose a quantitative measure based on the success probability of the post-processing algorithm to determine whether an experiment on a quantum device (or a classical simulator) succeeded. We also propose a procedure to modify bit strings observed from a Shor circuit to increase the success probability of a lattice-based post-processing algorithm. We report preliminary experiments conducted on IBM-Quantum quantum computers and near-future predictions based on noisy-device simulations. We conducted our experiments with the ibm_kawasaki device and discovered that the simplest circuit (7 qubits) from a 2-bit DLP instance achieves a sufficiently high success probability to proclaim the experiment successful. Experiments on another circuit from a slightly harder 2-bit DLP instance, on the other hand, did not succeed, and we determined that reducing the noise level by half is required to achieve a successful experiment. Finally, we give a near-term prediction based on required noise levels to solve some selected small DLP and integer factoring instances.
- Published
- 2021
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48. Corresponding ctDNA and tumor burden dynamics in metastatic melanoma patients on systemic treatment
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Michael E. Egger, Evan Alexander, Tracy Van Meter, Maiying Kong, Aye Aye Maung, Roland Valdes, Jr., Melissa Barousse Hall, and Mark W. Linder
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Melanoma ,Treatment monitoring ,Plasma ctDNA ,Tumor burden ,Tumor proliferation ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Radiographic imaging is the current standard for monitoring progression of tumor-burden and therapeutic resistance in patients with metastatic melanoma. Plasma circulating tumor DNA (ctDNA) has shown promise as a survelience tool, but longitudinal data on the dynamics between plasma ctDNA concentrations and radiographic imaging is lacking. We evaluated the relationship between longitudinal radiographic measures of tumor burden and ctDNA concentrations in plasma on 30 patients with metastatic melanoma on systemic treatment. In 9 patients with no radiographic evidence of disease over a total of 15 time points, ctDNA concentrations were undetectable. In 21 patients with radiographic tumor burden, ctDNA was detected in 81 % of 58 time points. Plasma ctDNA concentrations demonstrated a modest positive correlation with total tumor burden (TTB) measurements (R2= 0.49, p < 0.001), with the greatest degree of correlation observed under conditions of progressive disease (PD) (R2 = 0.91, p = 0.032). Plasma ctDNA concentrations were significantly greater at times of RECIST v1.1 progression (PD; 22.1 % ± 5.7 %) when compared to samples collected during stable disease (SD; 4.99 % ± 3.0 %) (p = 0.012); this difference was independent of total tumor burden (p = 0.997). Changes in plasma ctDNA showed a strong correlation with changes in TTB (R2= 0.88, p
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- 2024
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49. Framework for multi-stressor physiological response evaluation in amphibian risk assessment and conservation
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Jill A. Awkerman, Donna A. Glinski, W. Matthew Henderson, Robin Van Meter, and S. Thomas Purucker
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amphibian ,conservation ,risk assessment ,stressor ,physiology ,Evolution ,QH359-425 ,Ecology ,QH540-549.5 - Abstract
Controlled laboratory experiments are often performed on amphibians to establish causality between stressor presence and an adverse outcome. However, in the field, identification of lab-generated biomarkers from single stressors and the interactions of multiple impacts are difficult to discern in an ecological context. The ubiquity of some pesticides and anthropogenic contaminants results in potentially cryptic sublethal effects or synergistic effects among multiple stressors. Although biochemical pathways regulating physiological responses to toxic stressors are often well-conserved among vertebrates, different exposure regimes and life stage vulnerabilities can yield variable ecological risk among species. Here we examine stress-related biomarkers, highlight endpoints commonly linked to apical effects, and discuss differences in ontogeny and ecology that could limit interpretation of biomarkers across species. Further we identify promising field-based physiological measures indicative of potential impacts to health and development of amphibians that could be useful to anuran conservation. We outline the physiological responses to common stressors in the context of altered functional pathways, presenting useful stage-specific endpoints for anuran species, and discussing multi-stressor vulnerability in the larger framework of amphibian life history and ecology. This overview identifies points of physiological, ecological, and demographic vulnerability to provide context in evaluating the multiple stressors impacting amphibian populations worldwide for strategic conservation planning.
- Published
- 2024
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50. CARME – The Rise and Fall of a Sociological Space in the East
- Author
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van Meter, Karl M., primary
- Published
- 2023
- Full Text
- View/download PDF
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