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30 results on '"Van Loey, A.M."'

17. L-ascorbic acid improves the serum folate response to an oral dose of [6S]-5-methyltetrahydrofolic acid in healthy men

Author

Verlinde, P.H.C.J., Oey, I., Hendrickx, M.E., Van Loey, A.M., and Temme, E.H.M.

Subjects
Folic acid -- Dosage and administration, Folic acid -- Properties, Vitamin C -- Dosage and administration
Abstract

Objective: To investigate the effect of simultaneous administration of [6S]-5-methyltetrahydrofolic acid ([6S]-5-C[H.sub.3][H.sub.4]PteGlu) with L-ascorbic acid (L-AA) on serum folate concentrations in healthy male subjects. Subjects and methods: A total of nine healthy male volunteers were recruited. Serum folate concentrations were measured before and up to 8h after administration of each treatment (1) placebo, (2) 343 [micro]g [6S]-5-C[H.sub.3][H.sub.4]PteGlu), (3) 343 [micro]g [6S]5-C[H.sub.3][H.sub.4]PteGlu) with 289.4 mg L-AA and (4) 343 [micro]g [6S]-5-C[H.sub.3][H.sub.4]PteGlu) with 973.8 mg L-AA (n=10 samples per treatment). Results: Serum folate concentrations significantly increased compared with baseline values, starting from 30 min after [6S]5-C[H.sub.3][H.sub.4]PteGlu administration and remained significantly higher than baseline values during the first 6 h for treatments 3 and 4, and during the first 4 h for treatment 2. Maximal serum folate responses were observed between 0.5 and 1.5 h after [6S]5-C[H.sub.3][H.sub.4]PteGlu consumption and significantly differed between treatments 2 and 4 (P Conclusions: Administration of a physiological dose of [6S]-5-C[H.sub.3][H.sub.4]PteGlu with L-AA significantly improved the measured serum folate response in folate saturated healthy men. doi:10.1038/sj.ejcn.1602840; published online 11 July 2007 Keywords: [6S]-5-methyltetrahydrofolate; L-ascorbic acid; serum folate; short-term folate bioavailability, Introduction Folates are essential cofactors required for one-carbon transfer reactions in key biosynthetic and epigenetic processes (Stover, 2004). Folate deficiency is prevalent in underdeveloped countries, and even in the Western [...]

Published
2008

21. Effect of enzymes on serum and particle properties of carrot cell suspensions

Author

Sankaran, A.K., Nijsse, J., Cardinaels, R.M., Bialek, L., Shpigelman, A., Hendrickx, M.E., Moldenaers, P., Van Loey, A.M., Sankaran, A.K., Nijsse, J., Cardinaels, R.M., Bialek, L., Shpigelman, A., Hendrickx, M.E., Moldenaers, P., and Van Loey, A.M.

Abstract

Rheological properties of cell wall suspensions strongly depend on particle size and particle-particle interactions. In the present study, an experimental method was developed to study the effect of particle elasticity and electrostatic interactions on the rheological properties of cell suspensions. Enzymes were used to selectively depolymerize the pectin (backbone) and proteins in suspensions. The enzymatic treatments affected the physical properties, thus a hypothesis for the structure-function relationship of these biopolymers was formulated. The enzymatic treatment directly affected particle properties, resulting in looser cell walls as visualized by cryo-SEM. The effect of the enzymatic treatment on the storage modulus was measured as a function of total solid content (below critical packing fraction). Furthermore, experiments were performed in the presence of varying concentrations of sodium chloride in order to change the Debye screening length. Such method assisted in decoupling the electrostatic effects from particle elasticity. In addition, particle properties were measured directly by applying a compressive strain on the particles and measuring the normal force. By fitting the normal stress relaxation with a Maxwell model, particle properties such as time scale of relaxation and elasticity were obtained. It is suggested that for carrot suspensions, pectins on the cell walls could contribute to the particle hardness. The pectins on carrot cell walls are responsible for electrostatic interactions between particles.

Published
2015

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