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7. Differences in presentation, diagnosis and management of heart failure in women. A scientific statement of the Heart Failure Association of the ESC

Author

Rosano, Giuseppe M.C., primary, Stolfo, Davide, additional, Anderson, Lisa, additional, Abdelhamid, Magdy, additional, Adamo, Marianna, additional, Bauersachs, Johann, additional, Bayes‐Genis, Antoni, additional, Böhm, Michael, additional, Chioncel, Ovidiu, additional, Filippatos, Gerasimos, additional, Hill, Loreena, additional, Lainscak, Mitja, additional, Lambrinou, Ekaterini, additional, Maas, Angela H.E.M., additional, Massouh, Angela R., additional, Moura, Brenda, additional, Petrie, Mark C., additional, Rakisheva, Amina, additional, Ray, Robin, additional, Savarese, Gianluigi, additional, Skouri, Hadi, additional, Van Linthout, Sophie, additional, Vitale, Cristiana, additional, Volterrani, Maurizio, additional, Metra, Marco, additional, and Coats, Andrew J.S., additional

Published
2024
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8. Multidisciplinary care of peripartum heart failure: A scientific statement of the Heart Failure Association of the ESC

Author

Rakisheva, Amina, primary, Sliwa, Karen, additional, Bauersachs, Johann, additional, Van Linthout, Sophie, additional, Chopra, Vijay K., additional, Bayes‐Genis, Antoni, additional, Fruzzetti, Franca, additional, Cannatà, Antonio, additional, Deniau, Benjamin, additional, Mebazaa, Alexandre, additional, Savarese, Gianluigi, additional, Ray, Robin, additional, Vitale, Cristiana, additional, Metra, Marco, additional, and Rosano, Giuseppe M.C., additional

Published
2024
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11. Integration of implantable device therapy in patients with heart failure. A clinical consensus statement from the Heart Failure Association (HFA) and European Heart Rhythm Association (EHRA) of the European Society of Cardiology (ESC)

Author

Team Medisch, Circulatory Health, Verplegingswetenschap, Mullens, Wilfried, Dauw, Jeroen, Gustafsson, Finn, Mebazaa, Alexandre, Steffel, Jan, Witte, Klaus K., Delgado, Victoria, Linde, Cecilia, Vernooy, Kevin, Anker, Stefan D., Chioncel, Ovidiu, Milicic, Davor, Hasenfuß, Gerd, Ponikowski, Piotr, von Bardeleben, Ralph Stephan, Koehler, Friedrich, Ruschitzka, Frank, Damman, Kevin, Schwammenthal, Ehud, Testani, Jeffrey M., Zannad, Faiez, Böhm, Michael, Cowie, Martin R., Dickstein, Kenneth, Jaarsma, Tiny, Filippatos, Gerasimos, Volterrani, Maurizio, Thum, Thomas, Adamopoulos, Stamatis, Cohen-Solal, Alain, Moura, Brenda, Rakisheva, Amina, Ristic, Arsen, Bayes-Genis, Antoni, Van Linthout, Sophie, Tocchetti, Carlo Gabriele, Savarese, Gianluigi, Skouri, Hadi, Adamo, Marianna, Amir, Offer, Yilmaz, Mehmet Birhan, Simpson, Maggie, Tokmakova, Mariya, González, Arantxa, Piepoli, Massimo, Seferovic, Petar, Metra, Marco, Coats, Andrew J.S., Rosano, Giuseppe M.C., Team Medisch, Circulatory Health, Verplegingswetenschap, Mullens, Wilfried, Dauw, Jeroen, Gustafsson, Finn, Mebazaa, Alexandre, Steffel, Jan, Witte, Klaus K., Delgado, Victoria, Linde, Cecilia, Vernooy, Kevin, Anker, Stefan D., Chioncel, Ovidiu, Milicic, Davor, Hasenfuß, Gerd, Ponikowski, Piotr, von Bardeleben, Ralph Stephan, Koehler, Friedrich, Ruschitzka, Frank, Damman, Kevin, Schwammenthal, Ehud, Testani, Jeffrey M., Zannad, Faiez, Böhm, Michael, Cowie, Martin R., Dickstein, Kenneth, Jaarsma, Tiny, Filippatos, Gerasimos, Volterrani, Maurizio, Thum, Thomas, Adamopoulos, Stamatis, Cohen-Solal, Alain, Moura, Brenda, Rakisheva, Amina, Ristic, Arsen, Bayes-Genis, Antoni, Van Linthout, Sophie, Tocchetti, Carlo Gabriele, Savarese, Gianluigi, Skouri, Hadi, Adamo, Marianna, Amir, Offer, Yilmaz, Mehmet Birhan, Simpson, Maggie, Tokmakova, Mariya, González, Arantxa, Piepoli, Massimo, Seferovic, Petar, Metra, Marco, Coats, Andrew J.S., and Rosano, Giuseppe M.C.

Published
2024

12. Integration of implantable device therapy in patients with heart failure. A clinical consensus statement from the Heart Failure Association (HFA) and European Heart Rhythm Association (EHRA) of the European Society of Cardiology (ESC)

Author

Mullens, Wilfried, Dauw, Jeroen, Gustafsson, Finn, Mebazaa, Alexandre, Steffel, Jan, Witte, Klaus K., Delgado, Victoria, Linde, Cecilia, Vernooy, Kevin, Anker, Stefan D., Chioncel, Ovidiu, Milicic, Davor, Hasenfuss, Gerd, Ponikowski, Piotr, Stephan von Bardeleben, Ralph, Koehler, Friedrich, Ruschitzka, Frank, Damman, Kevin, Schwammenthal, Ehud, Testani, Jeffrey M., Zannad, Faiez, Boehm, Michael, Cowie, Martin R., Dickstein, Kenneth, Jaarsma, Tiny, Filippatos, Gerasimos, Volterrani, Maurizio, Thum, Thomas, Adamopoulos, Stamatis, Cohen-Solal, Alain, Moura, Brenda, Rakisheva, Amina, Ristic, Arsen, Bayes-Genis, Antoni, Van Linthout, Sophie, Tocchetti, Carlo Gabriele, Savarese, Gianluigi, Skouri, Hadi, Adamo, Marianna, Amir, Offer, Yilmaz, Mehmet Birhan, Simpson, Maggie, Tokmakova, Mariya, Gonzalez, Arantxa, Piepoli, Massimo, Seferovic, Petar, Metra, Marco, Coats, Andrew J. S., Rosano, Giuseppe M. C., Mullens, Wilfried, Dauw, Jeroen, Gustafsson, Finn, Mebazaa, Alexandre, Steffel, Jan, Witte, Klaus K., Delgado, Victoria, Linde, Cecilia, Vernooy, Kevin, Anker, Stefan D., Chioncel, Ovidiu, Milicic, Davor, Hasenfuss, Gerd, Ponikowski, Piotr, Stephan von Bardeleben, Ralph, Koehler, Friedrich, Ruschitzka, Frank, Damman, Kevin, Schwammenthal, Ehud, Testani, Jeffrey M., Zannad, Faiez, Boehm, Michael, Cowie, Martin R., Dickstein, Kenneth, Jaarsma, Tiny, Filippatos, Gerasimos, Volterrani, Maurizio, Thum, Thomas, Adamopoulos, Stamatis, Cohen-Solal, Alain, Moura, Brenda, Rakisheva, Amina, Ristic, Arsen, Bayes-Genis, Antoni, Van Linthout, Sophie, Tocchetti, Carlo Gabriele, Savarese, Gianluigi, Skouri, Hadi, Adamo, Marianna, Amir, Offer, Yilmaz, Mehmet Birhan, Simpson, Maggie, Tokmakova, Mariya, Gonzalez, Arantxa, Piepoli, Massimo, Seferovic, Petar, Metra, Marco, Coats, Andrew J. S., and Rosano, Giuseppe M. C.

Abstract

Implantable devices form an integral part of the management of patients with heart failure (HF) and provide adjunctive therapies in addition to cornerstone drug treatment. Although the number of these devices is growing, only few are supported by robust evidence. Current devices aim to improve haemodynamics, improve reverse remodelling, or provide electrical therapy. A number of these devices have guideline recommendations and some have been shown to improve outcomes such as cardiac resynchronization therapy, implantable cardioverter-defibrillators and long-term mechanical support. For others, more evidence is still needed before large-scale implementation can be strongly advised. Of note, devices and drugs can work synergistically in HF as improved disease control with devices can allow for further optimization of drug therapy. Therefore, some devices might already be considered early in the disease trajectory of HF patients, while others might only be reserved for advanced HF. As such, device therapy should be integrated into HF care programmes. Unfortunately, implementation of devices, including those with the greatest evidence, in clinical care pathways is still suboptimal. This clinical consensus document of the Heart Failure Association (HFA) and European Heart Rhythm Association (EHRA) of the European Society of Cardiology (ESC) describes the physiological rationale behind device-provided therapy and also device-guided management, offers an overview of current implantable device options recommended by the guidelines and proposes a new integrated model of device therapy as a part of HF care.

Published
2024
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16. The role of fibroblast – Cardiomyocyte interaction for atrial dysfunction in HFpEF and hypertensive heart disease

Author

Bode, David, Lindner, Diana, Schwarzl, Michael, Westermann, Dirk, Deissler, Peter, Primessnig, Uwe, Hegemann, Niklas, Blatter, Lothar A., van Linthout, Sophie, Tschöpe, Carsten, Schoenrath, Felix, Soltani, Sajjad, Stamm, Christof, Duesterhoeft, Volker, Rolim, Natale, Wisløff, Ulrik, Knosalla, Christoph, Falk, Volkmar, Pieske, Burkert M., Heinzel, Frank R., and Hohendanner, Felix

Published
2019
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17. Sex- and age-related differences in the inflammatory properties of cardiac fibroblasts: impact on the cardiosplenic axis and cardiac fibrosis

Author

Pappritz, Kathleen, primary, Puhl, Sarah-Lena, additional, Matz, Isabel, additional, Brauer, Erik, additional, Shia, Yi Xuan, additional, El-Shafeey, Muhammad, additional, Koch, Suzanne E., additional, Miteva, Kapka, additional, Mucha, Christin, additional, Duda, Georg N., additional, Petersen, Ansgar, additional, Steffens, Sabine, additional, Tschöpe, Carsten, additional, and Van Linthout, Sophie, additional

Published
2023
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22. Therapeutic Potential of HDL in Cardioprotection and Tissue Repair

Author

Van Linthout, Sophie, Frias, Miguel, Singh, Neha, De Geest, Bart, Rosenthal, Walter, Editor-in-chief, Barrett, James E., Series editor, Flockerzi, Veit, Series editor, Frohman, Michael A., Series editor, Geppetti, Pierangelo, Series editor, Hofmann, Franz B., Series editor, Michel, Martin C., Series editor, Moore, Philip, Series editor, Page, Clive P., Series editor, Thorburn, Andrew M., Series editor, Wang, KeWei, Series editor, von Eckardstein, Arnold, editor, and Kardassis, Dimitris, editor

Published
2015
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23. Pre‐discharge and early post‐discharge management of patients hospitalized for acute heart failure: a scientific statement by the Heart Failure Association ( HFA ) of the ESC

Author

Metra, Marco, primary, Adamo, Marianna, additional, Tomasoni, Daniela, additional, Mebazaa, Alexandre, additional, Bayes‐Genis, Antoni, additional, Abdelhamid, Magdy, additional, Adamopoulos, Stamatis, additional, Anker, Stefan D., additional, Bauersachs, Johann, additional, Belenkov, Yuri, additional, Böhm, Michael, additional, Gal, Tuvia Ben, additional, Butler, Javed, additional, Cohen‐Solal, Alain, additional, Filippatos, Gerasimos, additional, Gustafsson, Finn, additional, Hill, Loreena, additional, Jaarsma, Tiny, additional, Jankowska, Ewa A., additional, Lainscak, Mitja, additional, Lopatin, Yuri, additional, Lund, Lars, additional, McDonagh, Theresa, additional, Milicic, Davor, additional, Moura, Brenda, additional, Mullens, Wilfried, additional, Piepoli, Massimo, additional, Polovina, Marija, additional, Ponikowski, Piotr, additional, Rakisheva, Amina, additional, Ristic, Arsen, additional, Savarese, Gianluigi, additional, Seferovic, Petar, additional, Sharma, Rajan, additional, Thum, Thomas, additional, Tocchetti, Carlo G., additional, Van Linthout, Sophie, additional, Vitale, Cristiana, additional, Von Haehling, Stephan, additional, Volterrani, Maurizio, additional, Coats, Andrew JS, additional, Chioncel, Ovidiu, additional, and Rosano, Giuseppe, additional

Published
2023
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24. 105 Burning Heart - An Animal Model of Chronic Heart Failure Following Severe Burn Injury

Author

Hundeshagen, Gabriel, primary, Mertin, Viktoria, additional, Busch, Martin, additional, Thiele, Philipp, additional, Trogisch, Felix, additional, Heineke, Jörg, additional, Egger, Michael, additional, Bürkert, Hannah, additional, van Linthout, Sophie, additional, Mayr, Manuel, additional, Fielitz, Jens, additional, Kneser, Ulrich, additional, Most, Patrick, additional, and Ritterhoff, Julia, additional

Published
2023
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26. Pre-discharge and early post-discharge management of patients hospitalized for acute heart failure: A scientific statement by the Heart Failure Association of the ESC

Author

Metra, Marco, Adamo, Marianna, Tomasoni, Daniela, Mebazaa, Alexandre, Bayes-Genis, Antoni, Abdelhamid, Magdy, Adamopoulos, Stamatis, Anker, Stefan D., Bauersachs, Johann, Belenkov, Yuri, Boehm, Michael, Gal, Tuvia Ben, Butler, Javed, Cohen-Solal, Alain, Filippatos, Gerasimos, Gustafsson, Finn, Hill, Loreena, Jaarsma, Tiny, Jankowska, Ewa A., Lainscak, Mitja, Lopatin, Yuri, Lund, Lars H., McDonagh, Theresa, Milicic, Davor, Moura, Brenda, Mullens, Wilfried, Piepoli, Massimo, Polovina, Marija, Ponikowski, Piotr, Rakisheva, Amina, Ristic, Arsen, Savarese, Gianluigi, Seferovic, Petar, Sharma, Rajan, Thum, Thomas, Tocchetti, Carlo G., Van Linthout, Sophie, Vitale, Cristiana, Von Haehling, Stephan, Volterrani, Maurizio, Coats, Andrew J. S., Chioncel, Ovidiu, Rosano, Giuseppe, Metra, Marco, Adamo, Marianna, Tomasoni, Daniela, Mebazaa, Alexandre, Bayes-Genis, Antoni, Abdelhamid, Magdy, Adamopoulos, Stamatis, Anker, Stefan D., Bauersachs, Johann, Belenkov, Yuri, Boehm, Michael, Gal, Tuvia Ben, Butler, Javed, Cohen-Solal, Alain, Filippatos, Gerasimos, Gustafsson, Finn, Hill, Loreena, Jaarsma, Tiny, Jankowska, Ewa A., Lainscak, Mitja, Lopatin, Yuri, Lund, Lars H., McDonagh, Theresa, Milicic, Davor, Moura, Brenda, Mullens, Wilfried, Piepoli, Massimo, Polovina, Marija, Ponikowski, Piotr, Rakisheva, Amina, Ristic, Arsen, Savarese, Gianluigi, Seferovic, Petar, Sharma, Rajan, Thum, Thomas, Tocchetti, Carlo G., Van Linthout, Sophie, Vitale, Cristiana, Von Haehling, Stephan, Volterrani, Maurizio, Coats, Andrew J. S., Chioncel, Ovidiu, and Rosano, Giuseppe

Abstract

Acute heart failure is a major cause of urgent hospitalizations. These are followed by marked increases in death and rehospitalization rates, which then decline exponentially though they remain higher than in patients without a recent hospitalization. Therefore, optimal management of patients with acute heart failure before discharge and in the early post-discharge phase is critical. First, it may prevent rehospitalizations through the early detection and effective treatment of residual or recurrent congestion, the main manifestation of decompensation. Second, initiation at pre-discharge and titration to target doses in the early post-discharge period, of guideline-directed medical therapy may improve both short- and long-term outcomes. Third, in chronic heart failure, medical treatment is often left unchanged, so the acute heart failure hospitalization presents an opportunity for implementation of therapy. The aim of this scientific statement by the Heart Failure Association of the European Society of Cardiology is to summarize recent findings that have implications for clinical management both in the pre-discharge and the early post-discharge phase after a hospitalization for acute heart failure.

Published
2023
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27. Long COVID and the cardiovascular system - elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial and Pericardial Diseases

Author

Cardiologie zorg, Team Medisch, Experimental Cardiology Laboratory, Onderzoek Cardiovasculair Reg. Med., Circulatory Health, Regenerative Medicine and Stem Cells, Gyöngyösi, Mariann, Alcaide, Pilar, Asselbergs, Folkert W., Brundel, Bianca J.J.M., Camici, Giovanni G., Da Costa Martins, Paula, Ferdinandy, Péter, Fontana, Marianna, Girao, Henrique, Gnecchi, Massimiliano, Gollmann-Tepeköylü, Can, Kleinbongard, Petra, Krieg, Thomas, Madonna, Rosalinda, Paillard, Melanie, Pantazis, Antonis, Perrino, Cinzia, Pesce, Maurizio, Schiattarella, Gabriele G., Sluijter, Joost P.G., Steffens, Sabine, Tschöpe, Carsten, Van Linthout, Sophie, Davidson, Sean M., Cardiologie zorg, Team Medisch, Experimental Cardiology Laboratory, Onderzoek Cardiovasculair Reg. Med., Circulatory Health, Regenerative Medicine and Stem Cells, Gyöngyösi, Mariann, Alcaide, Pilar, Asselbergs, Folkert W., Brundel, Bianca J.J.M., Camici, Giovanni G., Da Costa Martins, Paula, Ferdinandy, Péter, Fontana, Marianna, Girao, Henrique, Gnecchi, Massimiliano, Gollmann-Tepeköylü, Can, Kleinbongard, Petra, Krieg, Thomas, Madonna, Rosalinda, Paillard, Melanie, Pantazis, Antonis, Perrino, Cinzia, Pesce, Maurizio, Schiattarella, Gabriele G., Sluijter, Joost P.G., Steffens, Sabine, Tschöpe, Carsten, Van Linthout, Sophie, and Davidson, Sean M.

Published
2023

28. Cardiac fibroblasts and mechanosensation in heart development, health and disease

Author

Onderzoek Cardiovasculair Reg. Med., Circulatory Health, Regenerative Medicine and Stem Cells, Pesce, Maurizio, Duda, Georg N., Forte, Giancarlo, Girao, Henrique, Raya, Angel, Roca-Cusachs, Pere, Sluijter, Joost P.G., Tschöpe, Carsten, Van Linthout, Sophie, Onderzoek Cardiovasculair Reg. Med., Circulatory Health, Regenerative Medicine and Stem Cells, Pesce, Maurizio, Duda, Georg N., Forte, Giancarlo, Girao, Henrique, Raya, Angel, Roca-Cusachs, Pere, Sluijter, Joost P.G., Tschöpe, Carsten, and Van Linthout, Sophie

Published
2023

29. Long COVID and the cardiovascular system—elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial and Pericardial Diseases

Author

Gyöngyösi, Mariann, Alcaide, Pilar, Asselbergs, Folkert W, Brundel, Bianca J J M, Camici, Giovanni G; https://orcid.org/0000-0002-0523-0695, da Costa Martins, Paula; https://orcid.org/0000-0002-0695-1187, Ferdinandy, Péter, Fontana, Marianna; https://orcid.org/0000-0002-9233-9831, Girao, Henrique; https://orcid.org/0000-0002-5786-8447, Gnecchi, Massimiliano; https://orcid.org/0000-0001-7435-4328, Gollmann-Tepeköylü, Can, Kleinbongard, Petra; https://orcid.org/0000-0003-3576-3772, Krieg, Thomas; https://orcid.org/0000-0002-5192-580X, Madonna, Rosalinda, Paillard, Melanie, Pantazis, Antonis, Perrino, Cinzia; https://orcid.org/0000-0002-2274-0048, Pesce, Maurizio; https://orcid.org/0000-0002-3097-8961, Schiattarella, Gabriele G, Sluijter, Joost P G; https://orcid.org/0000-0003-2088-9102, Steffens, Sabine; https://orcid.org/0000-0002-6892-9751, Tschöpe, Carsten, Van Linthout, Sophie; https://orcid.org/0000-0002-7581-7870, Davidson, Sean M, Gyöngyösi, Mariann, Alcaide, Pilar, Asselbergs, Folkert W, Brundel, Bianca J J M, Camici, Giovanni G; https://orcid.org/0000-0002-0523-0695, da Costa Martins, Paula; https://orcid.org/0000-0002-0695-1187, Ferdinandy, Péter, Fontana, Marianna; https://orcid.org/0000-0002-9233-9831, Girao, Henrique; https://orcid.org/0000-0002-5786-8447, Gnecchi, Massimiliano; https://orcid.org/0000-0001-7435-4328, Gollmann-Tepeköylü, Can, Kleinbongard, Petra; https://orcid.org/0000-0003-3576-3772, Krieg, Thomas; https://orcid.org/0000-0002-5192-580X, Madonna, Rosalinda, Paillard, Melanie, Pantazis, Antonis, Perrino, Cinzia; https://orcid.org/0000-0002-2274-0048, Pesce, Maurizio; https://orcid.org/0000-0002-3097-8961, Schiattarella, Gabriele G, Sluijter, Joost P G; https://orcid.org/0000-0003-2088-9102, Steffens, Sabine; https://orcid.org/0000-0002-6892-9751, Tschöpe, Carsten, Van Linthout, Sophie; https://orcid.org/0000-0002-7581-7870, and Davidson, Sean M

Abstract

Long COVID has become a world-wide, non-communicable epidemic, caused by long-lasting multiorgan symptoms that endure for weeks or months after SARS-CoV-2 infection has already subsided. This scientific document aims to provide insight into the possible causes and therapeutic options available for the cardiovascular manifestations of long COVID. In addition to chronic fatigue, which is a common symptom of long COVID, patients may present with chest pain, ECG abnormalities, postural orthostatic tachycardia, or newly developed supraventricular or ventricular arrhythmias. Imaging of the heart and vessels has provided evidence of chronic, post-infectious perimyocarditis with consequent left or right ventricular failure, arterial wall inflammation, or microthrombosis in certain patient populations. Better understanding of the underlying cellular and molecular mechanisms of long COVID will aid in the development of effective treatment strategies for its cardiovascular manifestations. A number of mechanisms have been proposed, including those involving direct effects on the myocardium, microthrombotic damage to vessels or endothelium, or persistent inflammation. Unfortunately, existing circulating biomarkers, coagulation, and inflammatory markers, are not highly predictive for either the presence or outcome of long COVID when measured 3 months after SARS-CoV-2 infection. Further studies are needed to understand underlying mechanisms, identify specific biomarkers, and guide future preventive strategies or treatments to address long COVID and its cardiovascular sequelae.

Published
2023

30. Pre-discharge and early post-discharge management of patients hospitalized for acute heart failure:A scientific statement by the Heart Failure Association of the ESC

Author

Metra, Marco, Adamo, Marianna, Tomasoni, Daniela, Mebazaa, Alexandre, Bayes-Genis, Antoni, Abdelhamid, Magdy, Adamopoulos, Stamatis, Anker, Stefan D, Bauersachs, Johann, Belenkov, Yuri, Böhm, Michael, Gal, Tuvia Ben, Butler, Javed, Cohen-Solal, Alain, Filippatos, Gerasimos, Gustafsson, Finn, Hill, Loreena, Jaarsma, Tiny, Jankowska, Ewa A., Lainscak, Mitja, Lopatin, Yuri, Lund, Lars H., McDonagh, Theresa, Milicic, Davor, Moura, Brenda, Mullens, Wilfried, Piepoli, Massimo, Polovina, Marija, Ponikowski, Piotr, Rakisheva, Amina, Ristic, Arsen, Savarese, Gianluigi, Seferovic, Petar, Sharma, Rajan, Thum, Thomas, Tocchetti, Carlo G., Van Linthout, Sophie, Vitale, Cristiana, Von Haehling, Stephan, Volterrani, Maurizio, Coats, Andrew J. S., Chioncel, Ovidiu, Rosano, Giuseppe, Metra, Marco, Adamo, Marianna, Tomasoni, Daniela, Mebazaa, Alexandre, Bayes-Genis, Antoni, Abdelhamid, Magdy, Adamopoulos, Stamatis, Anker, Stefan D, Bauersachs, Johann, Belenkov, Yuri, Böhm, Michael, Gal, Tuvia Ben, Butler, Javed, Cohen-Solal, Alain, Filippatos, Gerasimos, Gustafsson, Finn, Hill, Loreena, Jaarsma, Tiny, Jankowska, Ewa A., Lainscak, Mitja, Lopatin, Yuri, Lund, Lars H., McDonagh, Theresa, Milicic, Davor, Moura, Brenda, Mullens, Wilfried, Piepoli, Massimo, Polovina, Marija, Ponikowski, Piotr, Rakisheva, Amina, Ristic, Arsen, Savarese, Gianluigi, Seferovic, Petar, Sharma, Rajan, Thum, Thomas, Tocchetti, Carlo G., Van Linthout, Sophie, Vitale, Cristiana, Von Haehling, Stephan, Volterrani, Maurizio, Coats, Andrew J. S., Chioncel, Ovidiu, and Rosano, Giuseppe

Abstract

Acute heart failure is a major cause of urgent hospitalizations. These are followed by marked increases in death and rehospitalization rates, which then decline exponentially though they remain higher than in patients without a recent hospitalization. Therefore, optimal management of patients with acute heart failure before discharge and in the early post-discharge phase is critical. First, it may prevent rehospitalizations through the early detection and effective treatment of residual or recurrent congestion, the main manifestation of decompensation. Second, initiation at pre-discharge and titration to target doses in the early post-discharge period, of guideline-directed medical therapy may improve both short- and long-term outcomes. Third, in chronic heart failure, medical treatment is often left unchanged, so the acute heart failure hospitalization presents an opportunity for implementation of therapy. The aim of this scientific statement by the Heart Failure Association of the European Society of Cardiology is to summarize recent findings that have implications for clinical management both in the pre-discharge and the early post-discharge phase after a hospitalization for acute heart failure., Acute heart failure is a major cause of urgent hospitalizations. These are followed by marked increases in death and rehospitalization rates, which then decline exponentially though they remain higher than in patients without a recent hospitalization. Therefore, optimal management of patients with acute heart failure before discharge and in the early post-discharge phase is critical. First, it may prevent rehospitalizations through the early detection and effective treatment of residual or recurrent congestion, the main manifestation of decompensation. Second, initiation at pre-discharge and titration to target doses in the early post-discharge period, of guideline-directed medical therapy may improve both short- and long-term outcomes. Third, in chronic heart failure, medical treatment is often left unchanged, so the acute heart failure hospitalization presents an opportunity for implementation of therapy. The aim of this scientific statement by the Heart Failure Association of the European Society of Cardiology is to summarize recent findings that have implications for clinical management both in the pre-discharge and the early post-discharge phase after a hospitalization for acute heart failure.

Published
2023

34. Accurate assessment of LV function using the first automated 2D-border detection algorithm for small animals - evaluation and application to models of LV dysfunction

Author

Grune, Jana, Ritter, Daniel, Kräker, Kristin, Pappritz, Kathleen, Beyhoff, Niklas, Schütte, Till, Ott, Christiane, John, Cathleen, van Linthout, Sophie, Tschöpe, Carsten, Dechend, Ralf, Muller, Dominik N., Haase, Nadine, Grune, Tilman, Kintscher, Ulrich, and Kuebler, Wolfgang M.

Published
2019
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35. Cardiac remodelling part 2: clinical, imaging and laboratory findings: a review from the Biomarkers Working Group of the Heart Failure Association of the ESC

Author

Aimo, Alberto, Vergaro, Giuseppe, González, Arantxa, Barison, Andrea, Lupón, Josep, Delgado, Victoria, Richards, A Mark, de Boer, Rudolf A, Thum, Thomas, Arfsten, Henrike, Hülsmann, Martin, Falcao‐Pires, Inês, Díez, Javier, Foo, Roger SY, Chan, Mark Yan Yee, Anene‐Nzelu, George C, Abdelhamid, Magdy, Adamopoulos, Stamatis, Anker, Stefan D, Belenkov, Yuri, Gal, Tuvia B, Cohen‐Solal, Alain, Böhm, Michael, Chioncel, Ovidiu, Jankowska, Ewa A, Gustafsson, Finn, Hill, Loreena, Jaarsma, Tiny, Januzzi, James L, Jhund, Pardeep, Lopatin, Yuri, Lund, Lars H, Metra, Marco, Milicic, Davor, Moura, Brenda, Mueller, Christian, Mullens, Wilfried, Núñez, Julio, Piepoli, Massimo F, Rakisheva, Amina, Ristic, Arsen, Rossignol, Patrick, Savarese, Gianluigi, Tocchetti, Carlo G, van Linthout, Sophie, Volterrani, Maurizio, Seferovic, Petar, Rosano, Giuseppe, Coats, Andrew JS, Emdin, Michele, Bayes‐Genis, Antoni, Aimo, Alberto, Vergaro, Giuseppe, González, Arantxa, Barison, Andrea, Lupón, Josep, Delgado, Victoria, Richards, A Mark, de Boer, Rudolf A, Thum, Thoma, Arfsten, Henrike, Hülsmann, Martin, Falcao-Pires, Inê, Díez, Javier, Foo, Roger Sy, Chan, Mark Yan Yee, Anene-Nzelu, George C, Abdelhamid, Magdy, Adamopoulos, Stamati, Anker, Stefan D, Belenkov, Yuri, Gal, Tuvia B, Cohen-Solal, Alain, Böhm, Michael, Chioncel, Ovidiu, Jankowska, Ewa A, Gustafsson, Finn, Hill, Loreena, Jaarsma, Tiny, Januzzi, James L, Jhund, Pardeep, Lopatin, Yuri, Lund, Lars H, Metra, Marco, Milicic, Davor, Moura, Brenda, Mueller, Christian, Mullens, Wilfried, Núñez, Julio, Piepoli, Massimo F, Rakisheva, Amina, Ristic, Arsen, Rossignol, Patrick, Savarese, Gianluigi, Tocchetti, Carlo G, van Linthout, Sophie, Volterrani, Maurizio, Seferovic, Petar, Rosano, Giuseppe, Coats, Andrew J, Emdin, Michele, and Bayes-Genis, Antoni

Subjects
therapies, biomarker, heart failure, imaging, predictor, remodelling, ejection fraction, clinical
Abstract

In patients with heart failure (HF), the beneficial effects of drug and device therapies counteract to some extent ongoing cardiac damage. According to the net balance between these two factors, cardiac geometry and function may improve (reverse remodelling, RR) and even completely normalize (remission), or vice versa progressively deteriorate (adverse remodelling, AR). RR or remission predict a better prognosis, while AR has been associated with worsening clinical status and outcomes. The remodelling process ultimately involves all cardiac chambers, but has been traditionally evaluated in terms of left ventricular volumes and ejection fraction. This is the second part of a review paper by the Biomarker Study Group of the Heart Failure Association of the European Society of Cardiology dedicated to ventricular remodelling. This document examines the proposed criteria to diagnose RR and AR, their prevalence and prognostic value, and the variables predicting remodelling in patients managed according to current guidelines. Much attention will be devoted to RR in patients with HFrEF because most studies on cardiac remodelling focused on this setting.

Published
2022

36. Sex and age differences in sST2 in cardiovascular disease

Author

Beetler, Danielle J., primary, Bruno, Katelyn A., additional, Di Florio, Damian N., additional, Douglass, Erika J., additional, Shrestha, Swikriti, additional, Tschöpe, Carsten, additional, Cunningham, Madeleine W., additional, Krejčí, Jan, additional, Bienertová-Vašků, Julie, additional, Pankuweit, Sabine, additional, McNamara, Dennis M., additional, Jeon, Eun-Seok, additional, van Linthout, Sophie, additional, Blauwet, Lori A., additional, Cooper, Leslie T., additional, and Fairweather, DeLisa, additional

Published
2023
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37. Chronic heart failure as a sequel after severe burn injury – First insight into a novel pathological heart-skin axis

Author

Mertin, Viktoria, primary, Most, Patrick, additional, Busch, Martin, additional, Thiele, Philipp, additional, Trogisch, Felix A., additional, Heineke, Jörg, additional, Egger, Michael, additional, Bürkert, Hannah, additional, van Linthout, Sophie, additional, Mayr, Manuel, additional, Fielitz, Jens, additional, Kneser, Ulrich, additional, and Hundeshagen, Gabriel, additional

Published
2022
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43. SARS-CoV-2 infection causes prolonged cardiomyocyte swelling and inhibition of HIF1α translocation in an animal model COVID-19

Author

Daems, Margo, primary, Liesenborghs, Laurens, additional, Boudewijns, Robbert, additional, Simmonds, Steven J., additional, Kraisin, Sirima, additional, Van Wauwe, Jore, additional, Cuijpers, Ilona, additional, Raman, Jana, additional, Geuens, Nadèche, additional, Buyten, Tina Van, additional, Lox, Marleen, additional, Verhamme, Peter, additional, Van Linthout, Sophie, additional, Martinod, Kimberly, additional, Heymans, Stephane, additional, Tschöpe, Carsten, additional, Neyts, Johan, additional, and Jones, Elizabeth A. V., additional

Published
2022
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44. Congestion in heart failure: a circulating biomarker‐based perspective. A review from the Biomarkers Working Group of the Heart Failure Association, European Society of Cardiology

Author

Núñez, Julio, primary, de la Espriella, Rafael, additional, Rossignol, Patrick, additional, Voors, Adriaan A., additional, Mullens, Wilfried, additional, Metra, Marco, additional, Chioncel, Ovidiu, additional, Januzzi, James L., additional, Mueller, Christian, additional, Richards, A. Mark, additional, de Boer, Rudolf A., additional, Thum, Thomas, additional, Arfsten, Henrike, additional, González, Arantxa, additional, Abdelhamid, Magdy, additional, Adamopoulos, Stamatis, additional, Anker, Stefan D., additional, Gal, Tuvia Ben, additional, Biegus, Jan, additional, Cohen‐Solal, Alain, additional, Böhm, Michael, additional, Emdin, Michele, additional, Jankowska, Ewa A., additional, Gustafsson, Finn, additional, Hill, Loreena, additional, Jaarsma, Tiny, additional, Jhund, Pardeep S., additional, Lopatin, Yuri, additional, Lund, Lars H., additional, Milicic, Davor, additional, Moura, Brenda, additional, Piepoli, Massimo F., additional, Ponikowski, Piotr, additional, Rakisheva, Amina, additional, Ristic, Arsen, additional, Savarese, Gianluigi, additional, Tocchetti, Carlo G., additional, Van Linthout, Sophie, additional, Volterrani, Maurizio, additional, Seferovic, Petar, additional, Rosano, Giuseppe, additional, Coats, Andrew J.S., additional, and Bayes‐Genis, Antoni, additional

Published
2022
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46. Abstract P3020: Chronic Heart Failure As A Sequel After Severe Burn Injury - First Insight Into A Novel Pathological Heart-skin Axis

Author

Hundeshagen, Gabriel, primary, Mertin, Victoria, additional, Thiele, Philipp, additional, Jungmann, Andreas, additional, Trogisch, Felix A, additional, Drews, Oliver, additional, Heineke, Joerg, additional, Van Linthout, Sophie, additional, Fielitz, Jens, additional, Mayr, Manuel, additional, Busch, Martin, additional, Kneser, Ulrich, additional, and Most, Patrick, additional

Published
2022
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48. Long COVID and the cardiovascular system—elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial and Pericardial Diseases

Author

Gyöngyösi, Mariann, primary, Alcaide, Pilar, additional, Asselbergs, Folkert W, additional, Brundel, Bianca J J M, additional, Camici, Giovanni G, additional, Martins, Paula da Costa, additional, Ferdinandy, Péter, additional, Fontana, Marianna, additional, Girao, Henrique, additional, Gnecchi, Massimiliano, additional, Gollmann-Tepeköylü, Can, additional, Kleinbongard, Petra, additional, Krieg, Thomas, additional, Madonna, Rosalinda, additional, Paillard, Melanie, additional, Pantazis, Antonis, additional, Perrino, Cinzia, additional, Pesce, Maurizio, additional, Schiattarella, Gabriele G, additional, Sluijter, Joost P G, additional, Steffens, Sabine, additional, Tschöpe, Carsten, additional, Van Linthout, Sophie, additional, and Davidson, Sean M, additional

Published
2022
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49. Cardiac Remodelling Part 1: From Cells and Tissues to Circulating Biomarkers:From cells and tissues to circulating biomarkers. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology

Author

González, Arantxa, Richards, A Mark, Boer, Rudolf A, Thum, Thomas, Arfsten, Henrike, Hülsmann, Martin, Falcao‐Pires, Inês, Díez, Javier, Foo, Roger SY, Chan, Mark Yan Yee, Aimo, Alberto, Anene‐Nzelu, George C, Abdelhamid, Magdy, Adamopoulos, Stamatis, Anker, Stefan D, Belenkov, Yuri, Gal, Tuvia B, Cohen‐Solal, Alain, Böhm, Michael, Chioncel, Ovidiu, Delgado, Victoria, Emdin, Michele, Jankowska, Ewa A, Gustafsson, Finn, Hill, Loreena, Jaarsma, Tiny, Januzzi, James L, Jhund, Pardeep S, Lopatin, Yuri, Lund, Lars H, Metra, Marco, Milicic, Davor, Moura, Brenda, Mueller, Christian, Mullens, Wilfried, Núñez, Julio, Piepoli, Massimo F, Rakisheva, Amina, Ristic, Arsen, Rossignol, Patrick, Savarese, Gianluigi, Tocchetti, Carlo G, Van Linthout, Sophie, Volterrani, Maurizio, Seferovic, Petar, Rosano, Giuseppe, Coats, Andrew JS, and Bayes‐Genis, Antoni

Subjects
Tissue, Cells, Cardiology and Cardiovascular Medicine, Biomarkers, Remodeling
Abstract

Cardiac remodelling refers to changes in left ventricular (LV) structure and function over time, with a progressive deterioration that may lead to heart failure (HF) development (adverse remodelling) or vice versa a recovery in response to HF treatment. Adverse remodelling predicts a worse outcome, whilst reverse remodelling predicts a better prognosis. The geometry, systolic and diastolic function and electric activity of the left ventricle are affected, as well as the left atrium and on the long term even right heart chambers. At a cellular and molecular level, remodelling involves all components of cardiac tissue: cardiomyocytes, fibroblasts, endothelial cells and leukocytes. The molecular, cellular and histological signatures of remodelling may differ according to the cause and severity of cardiac damage, and clearly to the global trend toward worsening or recovery. These processes cannot be routinely evaluated through endomyocardial biopsies, but may be reflected by circulating levels of several biomarkers. Different classes of biomarkers (e.g., proteins, non-coding RNAs, metabolites and/or epigenetic modifications) and many biomarkers of each class might inform on some aspects on HF development, progression and long-term outcomes, but most have failed to enter clinical practice. This may be due to the biological complexity of remodelling, so that no single biomarker could provide great insight on remodelling when assessed alone. Another possible reason is a still incomplete understanding of the role of biomarkers in the pathophysiology of cardiac remodelling. Such role will be investigated in the first part of review paper on biomarkers of cardiac remodelling.

Published
2022

50. Congestion in heart failure:a circulating biomarker-based perspective. A review from the Biomarkers Working Group of the Heart Failure Association, European Society of Cardiology

Author

Núñez, Julio, de la Espriella, Rafael, Rossignol, Patrick, Voors, Adriaan A, Mullens, Wilfried, Metra, Marco, Chioncel, Ovidiu, Januzzi, James L, Mueller, Christian, Richards, A Mark, de Boer, Rudolf A, Thum, Thomas, Arfsten, Henrike, González, Arantxa, Abdelhamid, Magdy, Adamopoulos, Stamatis, Anker, Stefan D, Ben Gal, Tuvia, Biegus, Jan, Cohen-Solal, Alain, Böhm, Michael, Emdin, Michele, Jankowska, Ewa A., Gustafsson, Finn, Hill, Loreena, Jaarsma, Tiny, Jhund, Pardeep S, Lopatin, Yuri, Lund, Lars H., Milicic, Davor, Moura, Brenda, Piepoli, Massimo F, Ponikowski, Piotr, Rakisheva, Amina, Ristic, Arsen, Savarese, Gianluigi, Tocchetti, Carlo G., Van Linthout, Sophie, Volterrani, Maurizio, Seferovic, Petar, Rosano, Giuseppe, Coats, Andrew J. S., Bayes-Genis, Antoni, Núñez, Julio, de la Espriella, Rafael, Rossignol, Patrick, Voors, Adriaan A, Mullens, Wilfried, Metra, Marco, Chioncel, Ovidiu, Januzzi, James L, Mueller, Christian, Richards, A Mark, de Boer, Rudolf A, Thum, Thomas, Arfsten, Henrike, González, Arantxa, Abdelhamid, Magdy, Adamopoulos, Stamatis, Anker, Stefan D, Ben Gal, Tuvia, Biegus, Jan, Cohen-Solal, Alain, Böhm, Michael, Emdin, Michele, Jankowska, Ewa A., Gustafsson, Finn, Hill, Loreena, Jaarsma, Tiny, Jhund, Pardeep S, Lopatin, Yuri, Lund, Lars H., Milicic, Davor, Moura, Brenda, Piepoli, Massimo F, Ponikowski, Piotr, Rakisheva, Amina, Ristic, Arsen, Savarese, Gianluigi, Tocchetti, Carlo G., Van Linthout, Sophie, Volterrani, Maurizio, Seferovic, Petar, Rosano, Giuseppe, Coats, Andrew J. S., and Bayes-Genis, Antoni

Abstract

Congestion is a cardinal sign of heart failure (HF). In the past, it was seen as a homogeneous epiphenomenon that identified patients with advanced HF. However, current evidence shows that congestion in HF varies in quantity and distribution. This updated view advocates for a congestive-driven classification of HF according to onset (acute vs. chronic), regional distribution (systemic vs. pulmonary), compartment of distribution (intravascular vs. extravascular), and clinical vs. subclinical. Thus, this review will focus on the utility of circulating biomarkers for assessing and managing the different fluid overload phenotypes. This discussion focused on the clinical utility of the natriuretic peptides, carbohydrate antigen 125 (also called mucin 16), bio-adrenomedullin and mid-regional pro-adrenomedullin, ST2 (also known as interleukin-1 receptor-like 1), cluster of differentiation 146, troponin, C-terminal pro-endothelin-1, and parameters of haemoconcentration. The utility of circulation biomarkers on top of clinical evaluation, haemodynamics, and imaging needs to be better determined by dedicated studies. Some multiparametric frameworks in which these tools contribute to management are proposed.

Published
2022

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