10,014 results on '"Van Kampen A"'
Search Results
2. Analysis of 'Revaluation of the lower critical field in superconducting H_3S and LaH_10 (Nature Comm. 13, 3194, 2022)' by V. S. Minkov et al
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Hirsch, J. E. and van Kampen, M.
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Condensed Matter - Superconductivity - Abstract
In Nat Comm. 13,3194 (2022) [1] and an "Author Correction" to it [2], Minkov et al. presented magnetization data versus applied magnetic field for H_3S and LaH_10 under pressure, argued that the data provide evidence that these materials are superconducting at high temperatures, and extracted from the reported data the behavior of lower critical fields versus temperature. In several papers [3,4,5,6] analyzing Refs. [1,2] it was shown that the published magnetization data could not have been obtained from the reported measured data through the processes described in Refs. [1,2]. Recently, Minkov et al performed a revaluation of their experimental results [7] and argued that the results derived from their new analysis are consistent with the results reported earlier [1]. In addition, they made public the underlying data [8] from which the data published in Ref. [1] were derived. In this paper we analyze those underlying data and conclude that (a) the data published in Ref. [1] are incompatible with the underlying measured data, and (b) the revaluation analysis presented in Ref. [7] does not support the conclusions drawn by the authors in Ref. [7] nor Ref. [1].
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- 2024
3. Multi-layer optimisation of hybrid energy storage systems for electric vehicles
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Andriesse, Wouter, van Kampen, Jorn, and Hofman, Theo
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Electrical Engineering and Systems Science - Systems and Control - Abstract
This research presents a multi-layer optimization framework for hybrid energy storage systems (HESS) for passenger electric vehicles to increase the battery system's performance by combining multiple cell chemistries. Specifically, we devise a battery model capturing voltage dynamics, temperature and lifetime degradation solely using data from manufacturer datasheets, and jointly optimize the capacity distribution between the two batteries and the power split, for a given drive cycle and HESS topology. The results show that the lowest energy consumption is obtained with a hybrid solution consisting of a NCA-NMC combination, since this provides the best trade-off between efficiency and added weight.
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- 2024
4. System-level thermal and electrical modeling of battery systems for electric aircraft design
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Kuijpers, Thomas, van Kampen, Jorn, and Hofman, Theo
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Electrical Engineering and Systems Science - Systems and Control - Abstract
This work introduces a framework for simulating the electrical power consumption of an 8-seater electric aircraft equipped with high-energy-density NMC Lithium-ion cells. We propose an equivalent circuit model (ECM) to capture the thermal and electrical battery behavior. Furthermore, we assess the need for a battery thermal management system (BTMS) by determining heat generation at the cell level and optimize BTMS design to minimize energy consumption over a predefined flight regime. The proposed baseline battery design includes a 304-kWh battery system with BTMS, ensuring failure redundancy through two parallel switched battery banks. Simulation results explore the theoretical flight range without BTMS and reveal advantages in increasing battery capacity under specific conditions. Optimization efforts focus on BTMS design, highlighting the superior performance of water cooling over air cooling. However, the addition of a 9.9 kW water-cooled BTMS results in a 16.5% weight increase (387 kg) compared to no BTMS, reducing the simulated range of the aircraft from 480 km to 410 km. Lastly, we address a heating-induced thermal runaway scenario, demonstrating the robustness of the proposed battery design in preventing thermal runaway.
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- 2024
5. Deep reinforcement learning with symmetric data augmentation applied for aircraft lateral attitude tracking control
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Li, Yifei and van Kampen, Erik-jan
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence - Abstract
Symmetry is an essential property in some dynamical systems that can be exploited for state transition prediction and control policy optimization. This paper develops two symmetry-integrated Reinforcement Learning (RL) algorithms based on standard Deep Deterministic Policy Gradient (DDPG),which leverage environment symmetry to augment explored transition samples of a Markov Decision Process(MDP). The firstly developed algorithm is named as Deep Deterministic Policy Gradient with Symmetric Data Augmentation (DDPG-SDA), which enriches dataset of standard DDPG algorithm by symmetric data augmentation method under symmetry assumption of a dynamical system. To further improve sample utilization efficiency, the second developed RL algorithm incorporates one extra critic network, which is independently trained with augmented dataset. A two-step approximate policy iteration method is proposed to integrate training for two critic networks and one actor network. The resulting RL algorithm is named as Deep Deterministic Policy Gradient with Symmetric Critic Augmentation (DDPG-SCA). Simulation results demonstrate enhanced sample efficiency and tracking performance of developed two RL algorithms in aircraft lateral tracking control task.
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- 2024
6. AtLAST Science Overview Report
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Booth, Mark, Klaassen, Pamela, Cicone, Claudia, Mroczkowski, Tony, Cordiner, Martin A., Di Mascolo, Luca, Johnstone, Doug, van Kampen, Eelco, Lee, Minju M., Liu, Daizhong, Orlowski-Scherer, John, Saintonge, Amélie, Smith, Matthew W. L., Thelen, Alexander, Wedemeyer, Sven, Akiyama, Kazunori, Andreon, Stefano, Arzoumanian, Doris, Bakx, Tom J. L. C., Bot, Caroline, Bower, Geoffrey, Brajša, Roman, Chen, Chian-Chou, da Cunha, Elisabete, Eden, David, Ettori, Stefano, Gaches, Brandt, Hatziminaoglou, Evanthia, Luppe, Patricia, Magnelli, Benjamin, Marshall, Jonathan P., Montenegro-Montes, Francisco Miguel, Niemack, Michael, Nixon, Conor, de Pater, Imke, Perrott, Yvette, Raimundo, Sandra I., Redaelli, Elena, Richards, Anita, Rybak, Matus, Šarčević, Nikolina, Semenov, Dmitry, Spezzano, Silvia, Srinivasan, Sundar, Stanke, Thomas, Andreani, Paola, Beltrán, Maria T., Butler, Bryan J., Cantalupo, Sebastiano, Dagostino, Miguel Chavez, Duarte-Cabral, Ana, Emonts, Bjorn, Fletcher, Leigh, Gary, Dale E., Gunar, Stanislav, Hacar, Alvaro, Hagedorn, Bendix, Kaminski, Tomek, Kirton, Fiona, de Kleer, Katherine, Kontar, Eduard, Kuan, Yi-Jehng, Lightfoot, John, Lopez-Rodriguez, Enrique, Lundgren, Andreas, Milam, Stefanie N., Mohan, Atul, Moreno, Raphael, Motorina, Galina G., Moullet, Arielle, Pattle, Kate, Pellizzoni, Alberto, Peretto, Nicolas, Ramasawmy, Joanna, Ricci, Claudio, Rigby, Andrew J., Sánchez-Monge, Álvaro, Saberi, Maryam, Shimojo, Masumi, Simionescu, Aurora, Thompson, Mark, Traficante, Alessio, Vignali, Cristian, and White, Stephen M.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Submillimeter and millimeter wavelengths provide a unique view of the Universe, from the gas and dust that fills and surrounds galaxies to the chromosphere of our own Sun. Current single-dish facilities have presented a tantalising view of the brightest (sub-)mm sources, and interferometers have provided the exquisite resolution necessary to analyse the details in small fields, but there are still many open questions that cannot be answered with current facilities. In this report we summarise the science that is guiding the design of the Atacama Large Aperture Submillimeter Telescope (AtLAST). We demonstrate how tranformational advances in topics including star formation in high redshift galaxies, the diffuse circumgalactic medium, Galactic ecology, cometary compositions and solar flares motivate the need for a 50m, single-dish telescope with a 1-2 degree field of view and a new generation of highly multiplexed continuum and spectral cameras. AtLAST will have the resolution to drastically lower the confusion limit compared to current single-dish facilities, whilst also being able to rapidly map large areas of the sky and detect extended, diffuse structures. Its high sensitivity and large field of view will open up the field of submillimeter transient science by increasing the probability of serendipitous detections. Finally, the science cases listed here motivate the need for a highly flexible operations model capable of short observations of individual targets, large surveys, monitoring programmes, target of opportunity observations and coordinated observations with other observatories. AtLAST aims to be a sustainable, upgradeable, multipurpose facility that will deliver orders of magnitude increases in sensitivity and mapping speeds over current and planned submillimeter observatories., Comment: 47 pages, 12 figures. For further details on AtLAST see https://atlast.uio.no
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- 2024
7. The key science drivers for the Atacama Large Aperture Submillimeter Telescope (AtLAST)
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Booth, Mark, Klaassen, Pamela, Cicone, Claudia, Mroczkowski, Tony, Wedemeyer, Sven, Akiyama, Kazunori, Bower, Geoffrey, Cordiner, Martin A., Di Mascolo, Luca, Johnstone, Doug, van Kampen, Eelco, Lee, Minju M., Liu, Daizhong, Orlowski-Scherer, John, Saintonge, Amélie, Smith, Matthew, and Thelen, Alexander E.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Sub-mm and mm wavelengths provide a unique view of the Universe, from the gas and dust that fills and surrounds galaxies to the chromosphere of our own Sun. Current single-dish facilities have presented a tantalising view of the brightest (sub-)mm sources, and interferometers have provided the exquisite resolution necessary to analyse the details in small fields, but there are still many open questions that cannot be answered with current facilities: Where are all the baryons? How do structures interact with their environments? What does the time-varying (sub-)mm sky look like? In order to make major advances on these questions and others, what is needed now is a facility capable of rapidly mapping the sky spatially, spectrally, and temporally, which can only be done by a high throughput, single-dish observatory. An extensive design study for this new facility is currently being undertaken. In this paper, we focus on the key science drivers and the requirements they place on the observatory. As a 50m single dish telescope with a 1-2{\deg} field of view, the strength of the Atacama Large Aperture Submillimeter Telescope (AtLAST) is in science where a large field of view, highly multiplexed instrumentation and sensitivity to faint large-scale structure is important. AtLAST aims to be a sustainable, upgradeable, multipurpose facility that will deliver orders of magnitude increases in sensitivity and mapping speeds over current and planned telescopes., Comment: 12 pages, Conference proceedings paper for the 2024 SPIE Astronomical Telescopes + Instrumentation meeting
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- 2024
8. Atacama Large Aperture Submillimeter Telescope \mbox{(AtLAST)} Science: Probing the Transient and Time-variable Sky
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Orlowski-Scherer, John, Maccarone, Thomas J., Bright, Joe, Kaminski, Tomasz, Koss, Michael, Mohan, Atul, Montenegro-Montes, Francisco Miguel, Næss, Sig urd, Ricci, Claudio, Severgnini, Paola, Stanke, Thomas, Vignali, Cristian, Wedemeyer, Sven, Booth, Mark, Cicone, Claudia, Di Mascolo, Luca, Johnstone, Doug, Mroczkowski, Tony, Cordiner, Martin A., Greiner, Jochen, Hatziminaoglou, Evanthia, van Kampen, Eelco, Klaassen, Pamela, Lee, Minju M., Liu, Daizhong, Saintonge, Amelie, Smith, Matthew, and Thelen, Alexander E.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The study of transient and variable events, including novae, active galactic nuclei, and black hole binaries, has historically been a fruitful path for elucidating the evolutionary mechanisms of our universe. The study of such events in the millimeter and submillimeter is, however, still in its infancy. Submillimeter observations probe a variety of materials, such as optically thick dust, which are hard to study in other wavelengths. Submillimeter observations are sensitive to a number of emission mechanisms, from the aforementioned cold dust, to hot free-free emission, and synchrotron emission from energetic particles. Study of these phenomena has been hampered by a lack of prompt, high sensitivity submillimeter follow-up, as well as by a lack of high-sky-coverage submillimeter surveys. In this paper, we describe how the proposed Atacama Large Aperture Submillimeter Telescope (AtLAST) could fill in these gaps in our understanding of the transient universe. We discuss a number of science cases that would benefit from AtLAST observations, and detail how AtLAST is uniquely suited to contributing to them. In particular, AtLAST's large field of view will enable serendipitous detections of transient events, while its anticipated ability to get on source quickly and observe simultaneously in multiple bands make it also ideally suited for transient follow-up. We make theoretical predictions for the instrumental and observatory properties required to significantly contribute to these science cases, and compare them to the projected AtLAST capabilities. Finally, we consider the unique ways in which transient science cases constrain the observational strategies of AtLAST, and make prescriptions for how AtLAST should observe in order to maximize its transient science output without impinging on other science cases., Comment: 19 pages, 5 figures
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- 2024
9. Resolved UV and optical color gradients reveal environmental influence on galaxy evolution at redshift z$\sim$1.6
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Cramer, William J., Noble, A. G., Rudnick, G., Pigarelli, A., Wilson, G., Bahé, Y. M., Cooper, M. C., Demarco, R., Matharu, J., Miller, T. B., Muzzin, A., Nantais, J., Sportsman, W., van Kampen, E., Webb, T. M. A., and Yee, H. K. C.
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Astrophysics - Astrophysics of Galaxies - Abstract
The changes in colors across a galaxy are intimately connected to the galaxy's formation, growth, quenching history, and dust content. A particularly important epoch in the growth of galaxies is near $z \sim 2$ often referred to as `cosmic noon', where galaxies on average reach the peak of their star formation. We study a population of 125 cluster galaxies at $z \sim 1.6$ in three Hubble Space Telescope (HST) filters, F475W, F625W, and F160W, roughly corresponding to the rest-frame FUV, NUV, and r band, respectively. By comparing to a control sample of 200 field galaxies at similar redshift, we reveal clear, statistically significant differences in the overall spatially resolved colors and color gradients in galaxies across these two different environments. On average, cluster galaxies have redder UV colors in both the inner and outer regions bounded by $r_{\mathrm{50}}$, as well as an overall wider dispersion of outside-in color gradients. The presence of these observed differences, along with evidence from ancillary data from previous studies, strongly suggests that the environment drives these population-level color differences, by affecting the stellar populations and/or dust content., Comment: Accepted for publication in ApJ
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- 2024
10. Model Predictive Control Strategies for Electric Endurance Race Cars Accounting for Competitors Interactions
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van Kampen, Jorn, Moriggi, Mauro, Braghin, Francesco, and Salazar, Mauro
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Electrical Engineering and Systems Science - Systems and Control - Abstract
This paper presents model predictive control strategies for battery electric endurance race cars accounting for interactions with the competitors. In particular, we devise an optimization framework capturing the impact of the actions of the ego vehicle when interacting with competitors in a probabilistic fashion, jointly accounting for the optimal pit stop decision making, the charge times and the driving style in the course of the race. We showcase our method for a simulated 1h endurance race at the Zandvoort circuit, using real-life data of internal combustion engine race cars from a previous event. Our results show that optimizing both the race strategy as well as the decision making during the race is very important, resulting in a significant 21s advantage over an always overtake approach, whilst revealing the competitiveness of e-race cars w.r.t. conventional ones., Comment: Submitted to L-CSS 2024
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- 2024
11. Atacama Large Aperture Submillimeter Telescope (AtLAST) Science: Surveying the distant Universe
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van Kampen, Eelco, Bakx, Tom, De Breuck, Carlos, Chen, Chian-Chou, Dannerbauer, Helmut, Magnelli, Benjamin, Montenegro-Montes, Francisco Miguel, Okumura, Teppei, Pu, Sy-Yun, Rybak, Matus, Saintonge, Amelie, Cicone, Claudia, Hatziminaoglou, Evanthia, Hilhorst, Juliette, Klaassen, Pamela, Lee, Minju, Lovell, Christopher C., Lundgren, Andreas, Di Mascolo, Luca, Mroczkowski, Tony, Sommovigo, Laura, Booth, Mark, Cordiner, Martin A., Ivison, Rob, Johnstone, Doug, Liu, Daizhong, Maccarone, Thomas J., Smith, Matthew, Thelen, Alexander E., and Wedemeyer, Sven
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
During the most active period of star formation in galaxies, which occurs in the redshift range 1
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- 2024
12. Atacama Large Aperture Submillimeter Telescope (AtLAST) Science: Planetary and Cometary Atmospheres
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Cordiner, Martin A., Thelen, Alexander E., Cavalié, Thibault, Cosentino, Richard, Fletcher, Leigh N., Gurwell, Mark, de Kleer, Katherine, Kuan, Yi-Jehng, Lellouch, Emmanuel, Moullet, Arielle, Nixon, Conor, de Pater, Imke, Teanby, Nicholas A., Butler, Bryan, Charnley, Steven, Moreno, Raphael, Booth, Mark, Klaassen, Pamela, Cicone, Claudia, Mroczkowski, Tony, Di Mascolo, Luca, Johnstone, Doug, van Kampen, Eelco, Lee, Minju M., Liu, Daizhong, Maccarone, Thomas J., Saintonge, Amélie, Smith, Matthew, and Wedemeyer, Sven
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The study of planets and small bodies within our Solar System is fundamental for understanding the formation and evolution the Earth and other planets. Compositional and meteorological studies of the giant planets provide a foundation for understanding the nature of the most commonly observed exoplanets, while spectroscopic observations of the atmospheres of terrestrial planets, moons, and comets provide insights into the past and present-day habitability of planetary environments, and the availability of the chemical ingredients for life. While prior and existing (sub)millimeter observations have led to major advances in these areas, progress is hindered by limitations in the dynamic range, spatial and temporal coverage, as well as sensitivity of existing telescopes and interferometers. Here, we summarize some of the key planetary science use cases that factor into the design of the Atacama Large Aperture Submillimeter Telescope (AtLAST), a proposed 50-m class single dish facility: (1) to more fully characterize planetary wind fields and atmospheric thermal structures, (2) to measure the compositions of icy moon atmospheres and plumes, (3) to obtain detections of new, astrobiologically relevant gases and perform isotopic surveys of comets, and (4) to perform synergistic, temporally-resolved measurements in support of dedicated interplanetary space missions. The improved spatial coverage (several arcminutes), resolution ($\sim1.2''-12''$), bandwidth (several tens of GHz), dynamic range ($\sim10^5$) and sensitivity ($\sim1$ mK km s$^{-1}$) required by these science cases would enable new insights into the chemistry and physics of planetary environments, the origins of prebiotic molecules and the habitability of planetary systems in general., Comment: Submitted to Open Research Europe (AtLAST collection). 19 pages
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- 2024
13. Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Gas and dust in nearby galaxies
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Liu, Daizhong, Saintonge, Amelie, Bot, Caroline, Kemper, Francisca, Lopez-Rodriguez, Enrique, Smith, Matthew W. L., Stanke, Thomas, Andreani, Paola, Boselli, Alessandro, Cicone, Claudia, Davis, Timothy A., Hagedorn, Bendix, Lasrado, Akhil, Mao, Ann, Viti, Serena, Booth, Mark, Klaassen, Pamela, Mroczkowski, Tony, Bigiel, Frank, Chevance, Melanie, Cordiner, Martin A., Di Mascolo, Luca, Johnstone, Doug, Lee, Minju M., Maccarone, Thomas, Thelen, Alexander E., van Kampen, Eelco, and Wedemeyer, Sven
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Understanding the physical processes that regulate star formation and galaxy evolution are major areas of activity in modern astrophysics. Nearby galaxies offer unique opportunities to inspect interstellar medium (ISM), star formation (SF), radiative, dynamic and magnetic physics in great detail from sub-galactic (kpc) scales to sub-cloud (sub-pc) scales, from quiescent galaxies to starbursts, and from field galaxies to overdensities. In this case study, we discuss the major breakthroughs in this area of research that will be enabled by the Atacama Large Aperture Submillimeter Telescope (AtLAST), a proposed 50-m single-dish submillimeter telescope. The new discovery space of AtLAST comes from its exceptional sensitivity, in particular to extended low surface brightness emission, a very large 2 degree field of view, and correspondingly high mapping efficiency. This paper focuses on four themes which will particularly benefit from AtLAST: 1) the LMC and SMC, 2) extragalactic magnetic fields, 3) the physics and chemistry of the interstellar medium, and 4) star formation and galaxy evolution. With ~1000-2000h surveys each, AtLAST could deliver deep dust continuum maps of the entire LMC and SMC fields at parsec-scale resolution, high-resolution maps of the magnetic field structure, gas density, temperature and composition of the dense and diffuse ISM in ~100 nearby galaxies, as well as the first large-scale blind CO survey in the nearby Universe, delivering molecular gas masses for up to 10^6 galaxies (3 orders of magnitude more than current samples). Through such observing campaigns, AtLAST will have a profound impact on our understanding of the baryon cycle and star formation across a wide range of environments., Comment: 29 pages, 11 figues, submitted to Open Research Europe as part of the AtLAST collection: https://open-research-europe.ec.europa.eu/collections/atlast/about
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- 2024
14. Atacama Large Aperture Submillimeter Telescope (AtLAST) Science: The hidden circumgalactic medium
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Lee, Minju M., Schimek, Alice, Cicone, Claudia, Andreani, Paola, Popping, Gergö, Sommovigo, Laura, Appleton, Philip N., Bischetti, Manuela, Cantalupo, Sebastiano, Chen, Chian-Chou, Dannerbauer, Helmut, De Breuck, Carlos, Di Mascolo, Luca, Emonts, Bjorn H. C., Hatziminaoglou, Evanthia, Pensabene, Antonio, Rizzo, Francesca, Rybak, Matus, Shen, Sijing, Lundgren, Andreas, Booth, Mark, Klaassen, Pamela, Mroczkowski, Tony, Cordiner, Martin A., Johnstone, Doug, van Kampen, Eelco, Liu, Daizhong, Maccarone, Thomas, Saintonge, Amélie, Smith, Matthew, Thelen, Alexander E., and Wedemeyer, Sven
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Our knowledge of galaxy formation and evolution has incredibly progressed through multi-wavelength observational constraints of the interstellar medium (ISM) of galaxies at all cosmic epochs. However, little is known about the physical properties of the more diffuse and lower surface brightness reservoir of gas and dust that extends beyond ISM scales and fills dark matter haloes of galaxies up to their virial radii, the circumgalactic medium (CGM). New theoretical studies increasingly stress the relevance of the latter for understanding the feedback and feeding mechanisms that shape galaxies across cosmic times, whose cumulative effects leave clear imprints into the CGM. Recent studies are showing that a -- so far unconstrained -- fraction of the CGM mass may reside in the cold (T < 1e4 K) molecular and atomic phase, especially in high-redshift dense environments. These gas phases, together with the warmer ionised phase, can be studied in galaxies from z ~ 0 to z ~ 10 through bright far-infrared and sub-millimeter emission lines such as [C II] 158${\mu}$m, [O III] 88 ${\mu}$m, [C I] 609${\mu}$m, [C I] 370${\mu}$m, and the rotational transitions of CO. Imaging such hidden cold CGM can lead to a breakthrough in galaxy evolution studies but requires a new facility with the specifications of the proposed Atacama Large Aperture Submillimeter Telescope (AtLAST). In this paper, we use theoretical and empirical arguments to motivate future ambitious CGM observations with AtLAST and describe the technical requirements needed for the telescope and its instrumentation to perform such science., Comment: Submitted to Open Research Europe as part of the AtLAST collection: https://open-research-europe.ec.europa.eu/collections/atlast/about
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- 2024
15. Atacama Large Aperture Submillimeter Telescope (AtLAST) Science: Solar and stellar observations
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Wedemeyer, Sven, Barta, Miroslav, Brajsa, Roman, Chai, Yi, Costa, Joaquim, Gary, Dale, de Castro, Guillermo Gimenez, Gunar, Stanislav, Fleishman, Gregory, Hales, Antonio, Hudson, Hugh, Kirkaune, Mats, Mohan, Atul, Motorina, Galina, Pellizzoni, Alberto, Saberi, Maryam, Selhorst, Caius L., Simoes, Paulo J. A., Shimojo, Masumi, Skokic, Ivica, Sudar, Davor, Menezes, Fabian, White, Stephen, Booth, Mark, Klaassen, Pamela, Cicone, Claudia, Mroczkowski, Tony, Cordiner, Martin A., Di Mascolo, Luca, Johnstone, Doug, van Kampen, Eelco, Lee, Minju, Liu, Daizhong, Maccarone, Thomas, Orlowski-Scherer, John, Saintonge, Amelie, Smith, Matthew, and Thelen, Alexander E.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Observations at (sub-)millimeter wavelengths offer a complementary perspective on our Sun and other stars, offering significant insights into both the thermal and magnetic composition of their chromospheres. Despite the fundamental progress in (sub-)millimeter observations of the Sun, some important aspects require diagnostic capabilities that are not offered by existing observatories. In particular, simultaneous observations of the radiation continuum across an extended frequency range would facilitate the mapping of different layers and thus ultimately the 3D structure of the solar atmosphere. Mapping large regions on the Sun or even the whole solar disk at a very high temporal cadence would be crucial for systematically detecting and following the temporal evolution of flares, while synoptic observations, i.e., daily maps, over periods of years would provide an unprecedented view of the solar activity cycle in this wavelength regime. As our Sun is a fundamental reference for studying the atmospheres of active main sequence stars, observing the Sun and other stars with the same instrument would unlock the enormous diagnostic potential for understanding stellar activity and its impact on exoplanets. The Atacama Large Aperture Submillimeter Telescope (AtLAST), a single-dish telescope with 50\,m aperture proposed to be built in the Atacama desert in Chile, would be able to provide these observational capabilities. Equipped with a large number of detector elements for probing the radiation continuum across a wide frequency range, AtLAST would address a wide range of scientific topics including the thermal structure and heating of the solar chromosphere, flares and prominences, and the solar activity cycle. In this white paper, the key science cases and their technical requirements for AtLAST are discussed., Comment: 18 pages, 4 figures, submitted to Open Research Europe as part of a collection on the Atacama Large Aperture Submillimeter Telescope (AtLAST) -- revised version
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- 2024
16. Atacama Large Aperture Submillimeter Telescope (AtLAST) Science: Our Galaxy
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Klaassen, Pamela, Traficante, Alessio, Beltrán, Maria T., Pattle, Kate, Booth, Mark, Lovell, Joshua B., Marshall, Jonathan P., Hacar, Alvaro, Gaches, Brandt A. L., Bot, Caroline, Peretto, Nicolas, Stanke, Thomas, Arzoumanian, Doris, Cabral, Ana Duarte, Duchêne, Gaspard, Eden, David J., Hales, Antonio, Kauffmann, Jens, Luppe, Patricia, Marino, Sebastian, Redaelli, Elena, Rigby, Andrew J., Sánchez-Monge, Álvaro, Schisano, Eugenio, Semenov, Dmitry A., Spezzano, Silvia, Thompson, Mark A., Wyrowski, Friedrich, Cicone, Claudia, Mroczkowski, Tony, Cordiner, Martin A., Di Mascolo, Luca, Johnstone, Doug, van Kampen, Eelco, Lee, Minju M., Liu, Daizhong, Maccarone, Thomas J., Saintonge, Amélie, Smith, Matthew, Thelen, Alexander E., and Wedemeyer, Sven
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
As we learn more about the multi-scale interstellar medium (ISM) of our Galaxy, we develop a greater understanding for the complex relationships between the large-scale diffuse gas and dust in Giant Molecular Clouds (GMCs), how it moves, how it is affected by the nearby massive stars, and which portions of those GMCs eventually collapse into star forming regions. The complex interactions of those gas, dust and stellar populations form what has come to be known as the ecology of our Galaxy. Because we are deeply embedded in the plane of our Galaxy, it takes up a significant fraction of the sky, with complex dust lanes scattered throughout the optically recognisable bands of the Milky Way. These bands become bright at (sub-)millimetre wavelengths, where we can study dust thermal emission and the chemical and kinematic signatures of the gas. To properly study such large-scale environments, requires deep, large area surveys that are not possible with current facilities. Moreover, where stars form, so too do planetary systems, growing from the dust and gas in circumstellar discs, to planets and planetesimal belts. Understanding the evolution of these belts requires deep imaging capable of studying belts around young stellar objects to Kuiper belt analogues around the nearest stars. Here we present a plan for observing the Galactic Plane and circumstellar environments to quantify the physical structure, the magnetic fields, the dynamics, chemistry, star formation, and planetary system evolution of the galaxy in which we live with AtLAST; a concept for a new, 50m single-dish sub-mm telescope with a large field of view which is the only type of facility that will allow us to observe our Galaxy deeply and widely enough to make a leap forward in our understanding of our local ecology., Comment: 27 pages, submitted to Open Research Europe as part of the AtLAST collection: https://open-research-europe.ec.europa.eu/collections/atlast/about
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- 2024
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17. Atacama Large Aperture Submillimeter Telescope (AtLAST) Science: Resolving the Hot and Ionized Universe through the Sunyaev-Zeldovich effect
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Di Mascolo, Luca, Perrott, Yvette, Mroczkowski, Tony, Andreon, Stefano, Ettori, Stefano, Simionescu, Aurora, Raghunathan, Srinivasan, van Marrewijk, Joshiwa, Cicone, Claudia, Lee, Minju, Nelson, Dylan, Sommovigo, Laura, Booth, Mark, Klaassen, Pamela, Andreani, Paola, Cordiner, Martin A., Johnstone, Doug, van Kampen, Eelco, Liu, Daizhong, Maccarone, Thomas J., Morris, Thomas W., Saintonge, Amélie, Smith, Matthew, Thelen, Alexander E., and Wedemeyer, Sven
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
An omnipresent feature of the multi-phase ``cosmic web'' is that warm/hot (>$10^5$ K) ionized gas pervades it. This gas constitutes a relevant contribution to the overall universal matter budget across multiple scales, from the several tens of Mpc-scale IGM filaments, to the Mpc ICM, all the way down to the CGM surrounding individual galaxies, on scales from ~1 kpc up to their respective virial radii (~100 kpc). The study of the hot baryonic component of cosmic matter density represents a powerful means for constraining the intertwined evolution of galactic populations and large-scale cosmological structures, for tracing the matter assembly in the Universe and its thermal history. To this end, the SZ effect provides the ideal observational tool for measurements out to the beginnings of structure formation. The SZ effect is caused by the scattering of the photons from the cosmic microwave background off the hot electrons embedded within cosmic structures, and provides a redshift-independent perspective on the thermal and kinematic properties of the warm/hot gas. Still, current and future (sub)mm facilities have been providing only a partial view of the SZ Universe due to any combination of: limited angular resolution, spectral coverage, field of view, spatial dynamic range, sensitivity. In this paper, we motivate the development of a wide-field, broad-band, multi-chroic continuum instrument for the Atacama Large Aperture Submillimeter Telescope (AtLAST) by identifying the scientific drivers that will deepen our understanding of the complex thermal evolution of cosmic structures. On a technical side, this will necessarily require efficient multi-wavelength mapping of the SZ signal with an unprecedented spatial dynamic range (from arcsecond to degree scales) and we employ theoretical forecasts to determine the key instrumental constraints for achieving our goals. [abridged], Comment: 29 pages, 17 figures, 1 table. Submitted to Open Research Europe as part of the AtLAST Design Study collection: https://open-research-europe.ec.europa.eu/collections/atlast/about. Comments are welcome
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- 2024
18. The effect of SSRIs on unconditioned anxiety: a systematic review and meta-analysis of animal studies
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Heesbeen, Elise J., van Kampen, Tatum, Verdouw, P. Monika, van Lissa, Caspar, Bijlsma, Elisabeth Y., and Groenink, Lucianne
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- 2024
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19. Evaluating two implant designs in patients undergoing primary total knee arthroplasty using a novel measure of early optimal recovery: a retrospective observational study
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van Keulen, L. Z., Sonnega, R. J. A., Baas, N. R. A., Hogervorst, T., Muehlendyck, C., Bourras, P., ten Kate, T. A. J., Galvain, T., Dieleman, S., and van Kampen, P. M.
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- 2024
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20. A self-amplifying RNA RSV prefusion-F vaccine elicits potent immunity in pre-exposed and naïve non-human primates
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Vijayan, Aneesh, Vogels, Ronald, Groppo, Rachel, Jin, Yi, Khan, Selina, Van Kampen, Mirjam, Jorritsma, Sytze, Boedhoe, Satish, Baert, Miranda, van Diepen, Harry, Kuipers, Harmjan, Serroyen, Jan, del Valle, Jorge Reyes-, Broman, Ann, Nguyen, Lannie, Ray, Sayoni, Jarai, Bader, Arora, Jayant, Lifton, Michelle, Mildenberg, Benjamin, Morton, Georgeanna, Santra, Sampa, Grossman, Tamar R., Schuitemaker, Hanneke, Custers, Jerome, and Zahn, Roland
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- 2024
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21. ENCORE: a practical implementation to improve reproducibility and transparency of computational research
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van Kampen, Antoine H. C., Mahamune, Utkarsh, Jongejan, Aldo, van Schaik, Barbera D. C., Balashova, Daria, Lashgari, Danial, Pras-Raves, Mia, Wever, Eric J. M., Dane, Adrie D., García-Valiente, Rodrigo, and Moerland, Perry D.
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- 2024
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22. Pulmonary function trajectories in COVID-19 survivors with and without pre-existing respiratory disease
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Gach, Debbie, Beijers, Rosanne J. H. C. G., van Zeeland, Roel, van Kampen-van den Boogaart, Vivian, Posthuma, Rein, Schols, Annemie M. W. J., van den Bergh, Joop P., and van Osch, Frits H. M.
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- 2024
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23. Sensitive B-cell receptor repertoire analysis shows repopulation correlates with clinical response to rituximab in rheumatoid arthritis
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Pollastro, Sabrina, Musters, Anne, Balzaretti, Giulia, Niewold, Ilse, van Schaik, Barbera, Hässler, Signe, Verhoef, Catharina M., Pallardy, Marc, van Kampen, Antoine, Mariette, Xavier, and de Vries, Niek
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- 2024
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24. Systematic evaluation of B-cell clonal family inference approaches
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Balashova, Daria, van Schaik, Barbera D. C., Stratigopoulou, Maria, Guikema, Jeroen E. J., Caniels, Tom G., Claireaux, Mathieu, van Gils, Marit J., Musters, Anne, Anang, Dornatien C., de Vries, Niek, Greiff, Victor, and van Kampen, Antoine H. C.
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- 2024
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25. Young women’s conceptualisation and self-representation in online dating: a qualitative analysis
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Van Kampen, Astrid, Phillips, Matthew J., and Devenport, Scott
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- 2024
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26. A self-amplifying RNA RSV prefusion-F vaccine elicits potent immunity in pre-exposed and naïve non-human primates
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Aneesh Vijayan, Ronald Vogels, Rachel Groppo, Yi Jin, Selina Khan, Mirjam Van Kampen, Sytze Jorritsma, Satish Boedhoe, Miranda Baert, Harry van Diepen, Harmjan Kuipers, Jan Serroyen, Jorge Reyes- del Valle, Ann Broman, Lannie Nguyen, Sayoni Ray, Bader Jarai, Jayant Arora, Michelle Lifton, Benjamin Mildenberg, Georgeanna Morton, Sampa Santra, Tamar R. Grossman, Hanneke Schuitemaker, Jerome Custers, and Roland Zahn
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Science - Abstract
Abstract Newly approved subunit and mRNA vaccines for respiratory syncytial virus (RSV) demonstrate effectiveness in preventing severe disease, with protection exceeding 80% primarily through the generation of antibodies. An alternative vaccine platform called self-amplifying RNA (saRNA) holds promise in eliciting humoral and cellular immune responses. We evaluate the immunogenicity of a lipid nanoparticle (LNP)-formulated saRNA vaccine called SMARRT.RSV.preF, encoding a stabilized form of the RSV fusion protein, in female mice and in non-human primates (NHPs) that are either RSV-naïve or previously infected. Intramuscular vaccination with SMARRT.RSV.preF vaccine induces RSV neutralizing antibodies and cellular responses in naïve mice and NHPs. Importantly, a single dose of the vaccine in RSV pre-exposed NHPs elicits a dose-dependent anamnestic humoral immune response comparable to a subunit RSV preF vaccine. Notably, SMARRT.RSV.preF immunization significantly increases polyfunctional RSV.F specific memory CD4+ and CD8+ T-cells compared to RSV.preF protein vaccine. Twenty-four hours post immunization with SMARRT.RSV.preF, there is a dose-dependent increase in the systemic levels of inflammatory and chemotactic cytokines associated with the type I interferon response in NHPs, which is not observed with the protein vaccine. We identify a cluster of analytes including IL-15, TNFα, CCL4, and CXCL10, whose levels are significantly correlated with each other after SMARRT.RSV.preF immunization. These findings suggest saRNA vaccines have the potential to be developed as a prophylactic RSV vaccine based on innate, cellular, and humoral immune profiles they elicit.
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- 2024
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27. A conserved complex lipid signature marks human muscle aging and responds to short-term exercise
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Janssens, Georges E., Molenaars, Marte, Herzog, Katharina, Grevendonk, Lotte, Remie, Carlijn M. E., Vervaart, Martin A. T., Elfrink, Hyung L., Wever, Eric J. M., Schomakers, Bauke V., Denis, Simone W., Waterham, Hans R., Pras-Raves, Mia L., van Weeghel, Michel, van Kampen, Antoine H. C., Tammaro, Alessandra, Butter, Loes M., van der Rijt, Sanne, Florquin, Sandrine, Jongejan, Aldo, Moerland, Perry D., Hoeks, Joris, Schrauwen, Patrick, Vaz, Frédéric M., and Houtkooper, Riekelt H.
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- 2024
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28. Determinants of lenalidomide response with or without erythropoiesis-stimulating agents in myelodysplastic syndromes: the HOVON89 trial
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van de Loosdrecht, A. A., Cremers, E. M. P., Alhan, C., Duetz, C., in ’t Hout, F. E. M., Visser-Wisselaar, H. A., Chitu, D. A., Verbrugge, A., Cunha, S. M., Ossenkoppele, G. J., Janssen, J. J. W. M., Klein, S. K., Vellenga, E., Huls, G. A., Muus, P., Langemeijer, S. M. C., de Greef, G. E., te Boekhorst, P. A. W., Raaijmakers, M. H. G., van Marwijk Kooy, M., Legdeur, M. C., Wegman, J. J., Deenik, W., de Weerdt, O., van Maanen-Lamme, T. M., Jobse, P., van Kampen, R. J. W., Beeker, A., Wijermans, P. W., Biemond, B. J., Tanis, B. C., van Esser, J. W. J., Schaar, C. G., Noordzij-Nooteboom, H. S., Jacobs, E. M. G., de Graaf, A. O., Jongen-Lavrencic, M., Stevens-Kroef, M. J. P. L., Westers, T. M., and Jansen, J. H.
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- 2024
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29. A Two-dimensional Spatial Optimization Framework for Vehicle Powertrain Systems
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van Kampen, Jorn, Salazar, Mauro, and Hofman, Theo
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Electrical Engineering and Systems Science - Systems and Control - Abstract
This paper presents a modeling framework to optimize the two-dimensional placement of powertrain elements inside the vehicle, explicitly accounting for the rotation, relative placement and alignment. Specifically, we first capture the multi-level nature of the system mathematically, and construct a model that captures different powertrain component orientations. Second, we include the relative element placement as variables in the model and derive alignment constraints for both child components and parent subsystems to automatically connect mechanical ports. Finally, we showcase our framework on a four-wheel driven electric vehicle. Our results demonstrate that our framework is capable of efficiently generating system design solutions in a fully automated manner, only using basic component properties., Comment: Submitted to VPPC 2023
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- 2023
30. High resolution modeling of [CII], [CI], [OIII] and CO line emission from the ISM and CGM of a star forming galaxy at z ~ 6.5
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Schimek, Alice, Decataldo, Davide, Shen, Sijing, Cicone, Claudia, Baumschlager, Bernhard, van Kampen, Eelco, Klaassen, Pamela, Madau, Piero, Di Mascolo, Luca, Mayer, Lucio, Arroyave, Isabel Montoya, Mroczkowski, Tony, and Warraich, Jessie Harvir Kaur
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The circumgalactic medium (CGM) is a crucial component of galaxy evolution, but thus far its physical properties are highly unconstrained. As of yet, no cosmological simulation has reached convergence when it comes to constraining the cold and dense gas fraction of the CGM. Such components are also challenging to observe, and require sub-millimeter instruments with a high sensitivity to extended, diffuse emission, like the proposed Atacama Large Aperture Sub-millimetre telescope (AtLAST). We present a state-of-the-art theoretical effort at modeling the [CII], [CI](1-0), [CI](2-1), CO(3-2), and [OIII] line emissions of galaxies. We use the high-resolution cosmological zoom-in simulation Ponos, representing a star forming galaxy system at z = 6.5 ($M_*=2\times10^9~M_{\odot}$), undergoing a major merger. We adopt different modeling approaches based on the photoionisation code Cloudy. Our fiducial model uses radiative transfer post-processing with RamsesRT and Krome to create realistic FUV radiation fields, which we compare to sub-grid modeling approaches adopted in the literature. We find significant differences in the luminosity and in the contribution of different gas phases and galaxy components between the different modeling approaches. [CII] is the least model-dependant gas tracer, while [CI](1-0) and CO(3-2) are very model-sensitive. In all models, we find a significant contribution to the emission of [CII] (up to $\sim$10%) and [OIII] (up to $\sim$20%) from the CGM. [CII] and [OIII] trace different regions of the CGM: [CII] arises from an accreting filament and from tidal tails, while [OIII] traces a puffy halo surrounding the main disc, probably linked to SN feedback. We discuss our results in the context of current and future sub-mm observations with ALMA and AtLAST., Comment: Accepted for publication to A&A. 25 pages, 19 figures. Significant changes since version 1. Abstract summarised for arXiv submission
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- 2023
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31. The Spitzer Extragalactic Representative Volume Survey and DeepDrill extension: clustering of near-infrared galaxies
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van Kampen, Eelco, Lacy, Mark, Farrah, Duncan, Lagos, Claudia del P., Jarvis, Matt, Maraston, Claudia, Nyland, Kristina, Oliver, Seb, Surace, Jason, and Thorne, Jessica
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We have measured the angular auto-correlation function of near-infrared galaxies in SERVS+DeepDrill, the Spitzer Extragalactic Representative Volume Survey and its follow-up survey of the Deep Drilling Fields, in three large fields totalling over 20 sq. deg on the sky, observed in two bands centred on 3.6 and 4.5 micron. We performed this analysis on the full sample as well as on sources selected by [3.6]-[4.5] colour in order to probe clustering for different redshift regimes. We estimated the spatial correlation strength as well, using the redshift distribution from S-COSMOS with the same source selection. The strongest clustering was found for our bluest subsample, with z~0.7, which has the narrowest redshift distribution of all our subsamples. We compare these estimates to previous results from the literature, but also to estimates derived from mock samples, selected in the same way as the observational data, using deep light-cones generated from the SHARK semi-analytical model of galaxy formation. For all simulated (sub)samples we find a slightly steeper slope than for the corresponding observed ones, but the spatial clustering length is comparable in most cases., Comment: 20 pages, 15 figures, 6 tables, accepted for publication in MNRAS
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- 2023
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32. Cosmo-tomography toward PKS1830-211: Variability of the quasar and of its foreground molecular absorption monitored with ALMA
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Muller, S., Marti-Vidal, I., Combes, F., Gerin, M., Beelen, A., Horellou, C., Guelin, M., Aalto, S., Black, J. H., and van Kampen, E.
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Astrophysics - Astrophysics of Galaxies - Abstract
Time variability of astronomical sources provides crude information on their typical size and on the implied physical mechanisms. PKS1830-211 is a remarkable radio-bright lensed quasar with a foreground molecular absorber at z=0.89. Small-scale morphological changes in the core-jet structure of the quasar -- which is magnified by the lensing -- result in a varying illumination of the absorber screen, which in turn causes variations in the absorption profile. We aim to study the time variations of the system [...] in order to obtain constraints on both the quasar activity and small-scale structures in the ISM of the absorber. We used ALMA to monitor the submm continuum emission, together with the absorption spectra of the H2O and CH molecules, with 17 visits spread over six months in 2016. [...] From the continuum data, we followed the evolution of the flux density, flux-density ratio, spectral index, and differential polarization between the two lensed images of the quasar; all quantities show significant variations related to the intrinsic activity of the quasar. We propose a simple parametric model of a core plus a ballistic plasmon to account for the continuum evolution, from which we constrain a time delay of 25+/-3~days between lensed images. The spectral lines reveal significant variations in the foreground absorption. A PCA highlights apparent wavy time variations, possibly linked to the helical jet precession period of the quasar. From the deep averaged spectra towards the SW image, we detect the absorption of 13CH and estimate an abundance ratio of 12CH/13CH~150. We also measure the oxygen isotopic ratios, 16O/18O=65.3+/-0.7 and 18O/17O=11.5+/-0.5. Finally, we find a remarkable continuous shallow trough in the water absorption spanning a velocity interval of nearly 500 km/s. This broad absorption could be the signature of an extra-planar molecular component. [Abridged], Comment: Accepted for publication in A&A
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- 2023
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33. ENCORE: a practical implementation to improve reproducibility and transparency of computational research
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Antoine H. C. van Kampen, Utkarsh Mahamune, Aldo Jongejan, Barbera D. C. van Schaik, Daria Balashova, Danial Lashgari, Mia Pras-Raves, Eric J. M. Wever, Adrie D. Dane, Rodrigo García-Valiente, and Perry D. Moerland
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Science - Abstract
Abstract Reproducibility of computational research is often challenging despite established guidelines and best practices. Translating these guidelines into practical applications remains difficult. Here, we present ENCORE, an approach to enhance transparency and reproducibility by guiding researchers in how to structure and document a computational project. ENCORE builds on previous efforts in computational reproducibility and integrates all project components into a standardized file system structure. It utilizes pre-defined files as documentation templates, leverages GitHub for software versioning, and includes an HTML-based navigator. ENCORE is designed to be agnostic to the type of computational project, data, programming language, and ICT infrastructure, and does not rely on specific software tools. We also share our group’s experience using ENCORE, highlighting that the most significant challenge to the routine adoption of approaches like ours is the lack of incentives to motivate researchers to dedicate sufficient time and effort to ensure reproducibility.
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- 2024
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34. Pulmonary function trajectories in COVID-19 survivors with and without pre-existing respiratory disease
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Debbie Gach, Rosanne J. H. C. G. Beijers, Roel van Zeeland, Vivian van Kampen-van den Boogaart, Rein Posthuma, Annemie M. W. J. Schols, Joop P. van den Bergh, and Frits H. M. van Osch
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Medicine ,Science - Abstract
Abstract A significant proportion of COVID-19 survivors still experience a reduced diffusion capacity three and twelve months after discharge. We aimed to compare pulmonary function trajectories between hospitalized COVID-19 patients with pre-existing respiratory disease (PRD) and patients without pre-existing respiratory disease (Non-PRD) at three and twelve months after hospital discharge. This single-centre retrospective cohort study included COVID-19 patients admitted to the VieCuri Medical Centre (Venlo, the Netherlands) between February and December 2020 that were invited to the outpatient clinic at three and twelve months after discharge. During this visit, pulmonary function tests were performed and impairments were based on lower limit of normal. Data of 239 patients were analysed (65% male, 66 ± 10 years, and 26% with a history of respiratory disease). Three months after discharge, 49% and 64% of the Non-PRD patients (n = 177) and PRD patients (n = 62) had a low diffusion capacity, respectively. This improved over time in Non-PRD patients (p = 0.003), but not in PRD patients (p = 0.250). A low diffusion capacity was still observed in 34% and 57% of the Non-PRD and PRD group, respectively, twelve months after discharge. Pulmonary function impairments, mainly a reduced diffusion capacity, are observed among hospitalized COVID-19 patients with PRD and Non-PRD, at three and twelve months follow-up. Although diffusion capacity impairments restore over time in Non-PRD patients, poor recovery was observed among PRD patients.
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- 2024
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35. Optimal Endurance Race Strategies for a Fully Electric Race Car under Thermal Constraints
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van Kampen, Jorn, Herrmann, Thomas, Hofman, Theo, and Salazar, Mauro
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Mathematics - Optimization and Control ,Electrical Engineering and Systems Science - Systems and Control - Abstract
This paper presents a bi-level optimization framework to compute the maximum-distance race strategies for a fully electric endurance race car, whilst accounting for the low-level vehicle dynamics and the thermal limitations of the powertrain components. Thereby, the lower level computes the minimum-stint-time for a given charge time and stint length, whilst the upper level leverages that information to jointly optimize the stint length, charge time and number of pit stops, in order to maximize the driven distance in the course of a fixed-time endurance race. Specifically, we first extend a convex lap time optimization framework to capture low-level vehicle dynamics and thermal models, and use it to create a map linking the charge time and stint length to the achievable stint time. Second, we leverage the map to frame the maximum-race-distance problem as a mixed-integer second order conic program that can be efficiently solved in a few seconds to the global optimum with off-the-shelf optimization algorithms. Finally, we showcase our framework for a simulated 6h race around the Zandvoort circuit. Our results show that the optimal race strategy can involve partially charging the battery, and that, compared to the case where the stints are optimized for a fixed number of pit stops, jointly optimizing the stints and number of pit stops can significantly increase the driven distance and hence race performance by several laps., Comment: 16 pages, 21 figures. Accepted for publication in IEEE Transactions on Control Systems Technology. arXiv admin note: substantial text overlap with arXiv:2111.05784
- Published
- 2023
36. Validation of an algorithm that separates gaseous micro-embolic signals and artifacts during transcranial Doppler persistent foramen ovale examinations
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Rudolf W.M. Keunen, Hester Temmink, Mirjam Schipper, Geert Jan Romers, Paulien M. van Kampen, and Sayonara Daal
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Transcranial Doppler ,Persistent foramen ovale ,Algorithm ,Gaseous emboli ,Artifacts ,Medical technology ,R855-855.5 - Abstract
Objective: Persistent foramen ovale (PFO) is a risk factor for young stroke. Agitated saline serum is used to deliver small gaseous emboli to the brain in transcranial Doppler ultrasound (TCD) for the detection and grading of PFO. In this study we validated a PFO algorithm that can differentiate between gaseous emboli and artifacts. Methods: The validation cohort comprised 18 patients with positive PFO examinations. The PFO algorithm uses a binary tree that separates high-intensity transients signals (HITs) into gaseous emboli or artifacts based on intensity, zero-crossing, and velocity parameters. Results: The cohort exhibited 385 macroscopic gaseous emboli meeting the >3 dB criterion. An additional 137 gaseous emboli were noticed below the 3-dB intensity cutoff value. The low-intensity gaseous emboli included both macroscopic and microscopic air bubbles observed in curtains. Nearly all emboli (98 %) above the 3-dB level showed overt frequency modulation. The overall accuracy of the PFO algorithm in discriminating macroscopic gaseous emboli and artifacts was 96.4 %, with a similar percentage of sensitivity and specificity (96.4 %). The inter-observer agreement of human experts was excellent (ic-CC 0.989 and 0.953). Conclusions: Macroscopic gaseous emboli and artifacts during PFO exams can be accurately discriminated by the PFO algorithm. The PFO algorithm cannot be used as a standalone system as microscopic air bubbles might escape proper identification. This knowledge will be important in the design of future PFO algorithms which should make it possible to classify the PFO grade without the interference of humans.
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- 2024
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37. Patterns of the within-host evolution of human norovirus in immunocompromised individuals and implications for treatmentResearch in context
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Ray W. Izquierdo-Lara, Nele Villabruna, Dennis A. Hesselink, Claudia M.E. Schapendonk, Sol Ribó Pons, David Nieuwenhuijse, Jenny I.J. Meier, Ian Goodfellow, Virgil A.S.H. Dalm, Pieter L.A. Fraaij, Jeroen J.A. van Kampen, Marion P.G. Koopmans, and Miranda de Graaf
- Subjects
Norovirus ,Chronic infections ,Immunocompromised ,Virus evolution ,Immunoglobulin ,Antigenic evolution ,Medicine ,Medicine (General) ,R5-920 - Abstract
Summary: Background: Currently, there is no licensed treatment for chronic norovirus infections, but the use of intra-duodenally-delivered immunoglobulins is promising; nevertheless, varying results have limited their wide use. Little is known about the relationship between norovirus genetic diversity and treatment efficacy. Methods: We analyzed the norovirus within-host diversity and evolution in a cohort of 20 immunocompromised individuals using next-generation sequencing (NGS) and clone-based sequencing of the capsid (VP1) gene. Representative VP1s were expressed and their glycan receptor binding affinity and antigenicity were evaluated. Findings: The P2 domain, within the VP1, accumulated up to 30-fold more non-synonymous mutations than other genomic regions. Intra-host virus populations in these patients tended to evolve into divergent lineages that were often antigenically distinct. Several of these viruses were widely resistant to binding-blocking antibodies in immunoglobulin preparations. Notably, for one patient, a single amino-acid substitution in the P2 domain resulted in an immune-escape phenotype, and it was likely the main contributor to treatment failure. Furthermore, we found evidence for transmission of late-stage viruses between two immunocompromised individuals. Interpretation: The findings demonstrated that within-host noroviruses in chronic infections tend to evolve into antigenically distinct subpopulations. This antigenic evolution was likely caused by the remaining low immunity levels exerted by immunocompromised individuals, possibly undermining antiviral treatment. Our observations provide insights into norovirus (within-host) evolution and treatment. Funding: Erasmus MC grant mRACE, the European Union's Horizon 2020 research and innovation program under grant agreement No. 874735 (VEO), and the NWO STEVIN award (Koopmans).
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- 2024
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38. Winch Sizing for Ground-Generation Airborne Wind Energy Systems.
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Jesse I. S. Hummel, Tijmen S. C. Pollack, Dylan Eijkelhof, Erik-Jan van Kampen, and Roland Schmehl
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- 2024
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39. Reinforcement Learning-based Intelligent Flight Control for a Fixed-wing Aircraft to Cross an Obstacle Wall.
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Yifei Li and Erik-Jan van Kampen
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- 2024
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40. Local Infiltration Analgesia (LIA)
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van Beek, Rienk, van Kampen, Derk, Kort, Nanne P., editor, Hirschmann, Michael T., editor, Sierra, Rafael J., editor, and Thaler, Martin R., editor
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- 2024
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41. Adaptive Dynamic Programming for Flight Control
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van Kampen, Erik-Jan, Sun, Bo, Grimble, Michael J., Series Editor, Goodwin, Graham, Editorial Board Member, Harris, Thomas J., Editorial Board Member, Lee, Tong Heng, Editorial Board Member, Malik, Om P., Editorial Board Member, Man, Kim-Fung, Editorial Board Member, Olsson, Gustaf, Editorial Board Member, Ray, Asok, Editorial Board Member, Engell, Sebastian, Editorial Board Member, Yamamoto, Ikuo, Editorial Board Member, L'Afflitto, Andrea, editor, Inalhan, Gokhan, editor, and Shin, Hyo-Sang, editor
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- 2024
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42. Left ventricular fibrosis and CMR tissue characterization of papillary muscles in mitral valve prolapse patients
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Spampinato, Ricardo A., Marin-Cuartas, Mateo, van Kampen, Antonia, Fahr, Florian, Sieg, Franz, Strotdrees, Elfriede, Jahnke, Cosima, Klaeske, Kristin, Wiesner, Karoline, Morningstar, Jordan E., Nagata, Yasufumi, Izquierdo-Garcia, David, Dieterlen, Maja-Theresa, Norris, Russell A., Levine, Robert A., Paetsch, Ingo, and Borger, Michael A.
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- 2024
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43. Boson-jet and jet-jet azimuthal correlations at high transverse momenta
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van Kampen, A. M., Martinez, A. Bermudez, Banos, L. I. Estevez, Hautmann, F., Jung, H., Mendizabal, M., Figueroa, K. Moral, Prestel, S., Monfared, S. Taheri, Wang, Q., Wichmann, K., and Yang, H.
- Subjects
High Energy Physics - Phenomenology - Abstract
We discuss our recent results on azimuthal distributions in vector boson + jets and multi-jet production at the LHC, obtained from the matching of next-to-leading order (NLO) perturbative matrix elements with transverse momentum dependent (TMD) parton branching. We present a comparative analysis of boson-jet and jet-jet correlations in the back to-back region, and a study of the theoretical systematic uncertainties associated with the matching scale in the cases of TMD and collinear parton showers., Comment: 6 pages, 2 figures, contribution to proceedings of ICHEP 2022
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- 2022
44. A large-scale kinematic study of molecular gas in high-z cluster galaxies: Evidence for high levels of kinematic asymmetry
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Cramer, W. J., Noble, A. G., Massingill, K., Cairns, J., Clements, D. L., Cooper, M. C., Demarco, R., Matharu, J., McDonald, M., Muzzin, A., Nantais, J., Rudnick, G., Übler, H., van Kampen, E., Webb, T. M. A., Wilson, G., and Yee, H. K. C.
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Astrophysics - Astrophysics of Galaxies - Abstract
We investigate the resolved kinematics of the molecular gas, as traced by ALMA in CO (2-1), of 25 cluster member galaxies across three different clusters at a redshift of $z\sim1.6$. This is the first large-scale analysis of the molecular gas kinematics of cluster galaxies at this redshift. By separately estimating the rotation curve of the approaching and receding side of each galaxy via kinematic modeling, we quantify the difference in total circular velocity to characterize the overall kinematic asymmetry of each galaxy. 3/14 of the galaxies in our sample that we are able to model have similar degrees of asymmetry as that observed in galaxies in the field at similar redshift. However, this leaved 11/14 galaxies in our sample with significantly higher asymmetry, and some of these galaxies have degrees of asymmetry of up to $\sim$50 times higher than field galaxies observed at similar redshift. Some of these extreme cases also have one-sided tail-like morphology seen in the molecular gas, supporting a scenario of tidal and/or ram pressure interaction. Such stark differences in the kinematic asymmetry in clusters versus the field suggest the evolutionary influence of dense environments, established as being a major driver of galaxy evolution at low-redshift, is also active in the high-redshift universe., Comment: Submission pre-referee report
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- 2022
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45. Studies of multi-jet merging with Parton Branching TMD evolution
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van Kampen, Aron Mees
- Subjects
High Energy Physics - Phenomenology - Abstract
QCD predictions for final states with multiple jets in hadron collisions make use of multi-jet merging methods, which allow one to combine consistently the contributions from hard scattering matrix elements with different parton multiplicities and parton showers. In this article I consider a multi-jet merging method that has recently been proposed to take into account the effects of transverse momentum dependent (TMD) evolution and parton shower, and present studies focusing on the application of this method to jets associated with Drell-Yan (DY) production in the region of high masses., Comment: 6 pages, 3 figures. Contribution at the XXIX International Workshop on Deep-Inelastic Scattering and Related Subjects
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- 2022
46. A Large-scale Kinematic Study of Molecular Gas in High-z Cluster Galaxies: Evidence for High Levels of Kinematic Asymmetry
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Cramer, WJ, Noble, AG, Massingill, K, Cairns, J, Clements, DL, Cooper, MC, Demarco, R, Matharu, J, McDonald, M, Muzzin, A, Nantais, J, Rudnick, G, Übler, H, van Kampen, E, Webb, TMA, Wilson, G, and Yee, HKC
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Astronomical Sciences ,Physical Sciences ,Astronomical and Space Sciences ,Atomic ,Molecular ,Nuclear ,Particle and Plasma Physics ,Physical Chemistry (incl. Structural) ,Astronomy & Astrophysics ,Astronomical sciences ,Particle and high energy physics ,Space sciences - Abstract
Abstract: We investigate the resolved kinematics of the molecular gas, as traced by the Atacama Large Millimeter/submillimeter Array in CO (2−1), of 25 cluster member galaxies across three different clusters at a redshift of z ∼ 1.6. This is the first large-scale analysis of the molecular gas kinematics of cluster galaxies at this redshift. By separately estimating the rotation curve of the approaching and receding sides of each galaxy via kinematic modeling, we quantify the difference in total circular velocity to characterize the overall kinematic asymmetry of each galaxy. 3/14 of the galaxies in our sample that we are able to model have similar degrees of asymmetry as that observed in galaxies in the field at similar redshift based on observations of mainly ionized gas. However, this leaves 11/14 galaxies in our sample with significantly higher asymmetry, and some of these galaxies have degrees of asymmetry of up to ∼50 times higher than field galaxies observed at similar redshift. Some of these extreme cases also have one-sided tail-like morphology seen in the molecular gas, supporting a scenario of tidal and/or ram pressure interaction. Such stark differences in the kinematic asymmetry in clusters versus the field suggest the evolutionary influence of dense environments, established as being a major driver of galaxy evolution at low redshift, is also active in the high-redshift universe.
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- 2023
47. Science development study for the Atacama Large Aperture Submillimeter Telescope (AtLAST): Solar and stellar observations [version 1; peer review: 1 approved, 2 approved with reservations]
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Yi Chai, Roman Brajša, Dale Gary, Joaquim Costa, Stanislav Gunar, Guillermo Gimenez de Castro, Hugh Hudson, Pamela Klaassen, Gregory Fleishman, Atul Mohan, Mats Kirkaune, Alberto Pellizzoni, Mark Booth, Galina Motorina, Caius L. Selhorst, Maryam Saberi, Masumi Shimojo, Paulo J. A. Simoes, Davor Sudar, Ivica Skokić, Stephen M. White, Fabian Menezes, Amelie Saintonge, John Orlowski-Scherer, Antonio Hales, Claudia Cicone, Tony Mroczkowski, Doug Johnstone, Luca Di Mascolo, Minju Lee, Eelco van Kampen, Thomas Maccarone, Daizhong Liu, Matthew Smith, Martin A. Cordiner, Alexander E. Thelen, Miroslav Barta, and Sven Wedemeyer
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Sun activity ,Sun atmosphere ,Sun filaments ,prominences ,Sun flares ,magnetic fields ,eng ,Science ,Social Sciences - Abstract
Observations at (sub-)millimeter wavelengths offer a complementary perspective on our Sun and other stars, offering significant insights into both the thermal and magnetic composition of their chromospheres. Despite the fundamental progress in (sub-)millimeter observations of the Sun, some important aspects require diagnostic capabilities that are not offered by existing observatories. In particular, simultaneously observations of the radiation continuum across an extended frequency range would facilitate the mapping of different layers and thus ultimately the 3D structure of the solar atmosphere. Mapping large regions on the Sun or even the whole solar disk at a very high temporal cadence would be crucial for systematically detecting and following the temporal evolution of flares, while synoptic observations, i.e., daily maps, over periods of years would provide an unprecedented view of the solar activity cycle in this wavelength regime. As our Sun is a fundamental reference for studying the atmospheres of active main sequence stars, observing the Sun and other stars with the same instrument would unlock the enormous diagnostic potential for understanding stellar activity and its impact on exoplanets. The Atacama Large Aperture Submillimeter Telescope (AtLAST), a single-dish telescope with 50m aperture proposed to be built in the Atacama desert in Chile, would be able to provide these observational capabilities. Equipped with a large number of detector elements for probing the radiation continuum across a wide frequency range, AtLAST would address a wide range of scientific topics including the thermal structure and heating of the solar chromosphere, flares and prominences, and the solar activity cycle. In this white paper, the key science cases and their technical requirements for AtLAST are discussed.
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- 2024
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48. Optimal Endurance Race Strategies for a Fully Electric Race Car Under Thermal Constraints.
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Jorn van Kampen, Thomas Herrmann, Theo Hofman, and Mauro Salazar
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- 2024
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49. Model Predictive Control Strategies for Electric Endurance Race Cars Accounting for Competitors' Interactions.
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Jorn van Kampen, Mauro Moriggi, Francesco Braghin, and Mauro Salazar
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- 2024
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50. Back-to-back azimuthal correlations in Z+jet events at high transverse momentum in the TMD parton branching method at next-to-leading order
- Author
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Yang, H., Martinez, A. Bermudez, Banos, L. I. Estevez, Hautmann, F., Jung, H., Mendizabal, M., Figueroa, K. Moral, Prestel, S., Monfared, S. Taheri, van Kampen, A. M., Wang, Q., and Wichmann, K.
- Subjects
High Energy Physics - Phenomenology ,Nuclear Theory - Abstract
Azimuthal correlations in Z+jet production at large transverse momenta are computed by matching Parton - Branching (PB) TMD parton distributions and showers with NLO calculations via MCatNLO. The predictions are compared with those for dijet production in the same kinematic range. The azimuthal correlations $\Delta\phi$ between the Z boson and the leading jet are steeper compared to those in dijet production at transverse momenta ${\cal O}(100)$ GeV, while they become similar for very high transverse momenta ${\cal O}(1000)$ GeV. The different patterns of Z+jet and dijet azimuthal correlations can be used to search for potential {\it factorization - breaking} effects in the back-to-back region, which depend on the different color and spin structure of the final states and their interferences with the initial states. In order to investigate these effects experimentally, we propose to measure the ratio of the distributions in $\Delta\phi$ for Z+jet - and multijet production at low and at high transverse momenta, and compare the results to predictions obtained assuming factorization. We examine the role of theoretical uncertainties by performing variations of the factorization scale, renormalization scale and matching scale. In particular, we present a comparative study of matching scale uncertainties in the cases of PB-TMD and collinear parton showers., Comment: Replaced with version accepted for publication in EPJC
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- 2022
- Full Text
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