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3. Abstract form for the Irish Journal of Medical Science v workshop on gastroduodenal pathology and Helicobacter pylori July 5th — 7th 1992 — Dublin, Ireland

Author

Logan, R. P. H., Gummett, P. A., Walker, M. M., Karim, Q. N., Baron, J. H., Misiewicz, J. J., Trieber, G., Walker, S., Klotz, U., Lozniewski, A., Weber, M., de Korwin, J. D., Floquet, J., Conroy, M. C., Burdin, J. C., Mannes, G. A., Bayerdörffer, E., Höchter, W., Weingart, J., Heldwein, W., Sommer, A., Müller-Lissner, S., Bomschein, W., Miehlke, S., Weinzierl, M., Ruckdeschel, G., von Wulffen, H., Köpcke, W., Stolte, M., Rune, S. J., Justesen, T., Hansen, J. M., Jensen, T. G., Eriksen, J., Thomsen, O. ø., Scheibel, J., Bonnevie, O., Bremmelgaard, A., Vilien, M., Knuhtsen, S., Elsborg, L., Hansen, J., Lauritsen, K., Wulff, H. R., Boixeda, D., Ballestero, S., Cantón, R., De Rafael, L., Martinm de Argila, C., Pozuelo, M. J., Sampedro, J., Baquero, F., Grigoriev, P. Ya., Isakov, V. A., Iakovenko, E. P., Hirschl, A. M., Brandstätter, G., Dragosics, B., Hentschel, E., Kundi, M., Rotter, M. L., Schütze, K., Taufer, M., Neri M, Susi D, Bovani I, Pindo R, Cuccurullo F., Coelho, L. G. V., Passos, M. C. F., Chausson, Y., Vieira, W. L. S., Castro, F. J., Franco, J. M. M., Fernandes, M. L. M., Castro, L. P., Jonas, C., De Koster, E., Van Gossum, M., Depierreux, M., Cheval, M., Deltenre, M., Schütz, E., Bethke, B., Lee, A., Hegedus, E., O’Rourke, J., Larsson, H., Sjöstedt, S., Veress, B., Nord, C. E., Sobala, G. M., George, R., Tompkins, D., Finlay, J., Manning, A., Sant, S., Xia, H. X., Daw, M., Gilvarry, J., Keane, C. T., O’Morain, C., Rubio, M. A., Hegarty, B., Blum, A. L., Sulser, E., Stadelmann, O., Munoz, N., Buiatti, E., Vivas, J., Oliver, W., Cano, E., Peraza, S., Castro, D., Sanchez, V., Andrade, O., Benz, M., Mendz, G. L., Hazell, S. L., Salmela, K. S., Roire, R. P., Hook-Nikanne, J., Kosunen, T. U., Salaspur, M., Luke, C. J., Reynolds, D. D. J., Penn, C. W., Bode, G., Mauch, F., Ditschuneit, H., Malfertheiner, P., Ferrero, Richard L., Agnes Labigne, Eaton, K. A., Krakowka, S., Mobley, H. L. T., Hu, Li-Tai, Foxall, P. A., Moran, A. P., Helander, I. M., Altman, C., Sobhani, I., Vissugaire, C., Migrant, M., Etienne, J. P., Sommi, P., Ricci, V., Fiocca, R., Cova, E., Figura, N., Romano, M., Ivey, K. J., Solcia, E., Ventura, U., Nilius, M., Schieffer, S., Hengels, K. J., Jablonowski, H., Strohmeyer, G., Cabrai, M. D., Barbosa, A. J. A., Lima Hr., G. F., Oliveira, C. A., Polak, J. M., Oderda, G., Villani, L., Altare, F., Morra, I., Miserendino, L., Ansaldi, N., Dixon, M. F., Wyatt, J. I., Axon, A. T. R., Beattie, S., Hamilton, H., Shabib, S., Cutz, E., Drumm, B., Sherman, P., Noach, L. A., Rolf, T., Bosma, N. B., Schwartz, M. P., Oosting, J., Rauws, E. A. J., Tytgat, G. N. J., Andrew, A., Nardone, G., d’Ormiento, F., Pontillo, M., Lobo, A. J., Uff, J. S., McNulty, C. N. M., Wilkinson, S. P., Suriani, R., Pallante, C., Ravizza, M., Galliano, D., Sallio, D., Malandrino, M., Oneglio, R., Colozza, M., Mazzucco, D., Gaia, E., Eidt, S., Vincent, P., Gottrand, F., Turck, D., Lecomte-Houcke, M., Leclerc, H., Bonvicini, F., Pretolani, S., Baraldini, M., Cilla, D., Baldinelli, S., Bazocchi, E., Acampora, P., Careddu, N., Brocchi, E., Gasbarrini, G., Joubert, M., Bazin, N., Thiaucourt, D., Protte, E., Gissler, C., Duprez, A., Merlin, P., Forestier, S., Labenz, J., Gyenes, E., Rühl, G. H., Börsch, G., Daskalopoulos, G., Carrick, J., Lian, R., Wagner, S., Bleck, J., Gebel, M., Bär, W., Manns, M., Lamouliatte, H., Bernard, P. H., Cayla, R., Vialette, G., Quinton, A., Mégraud, F., Lemaire, M., Quinten, A., De Mascarel, A., Webb, P., Forman, D., Knight, T., Wilson, A., Graves, S., Newell, D., Elder, J., Tonelli, E., Gatte, M. R. A., Ghironzi, G. C., Giulianelli, G., Bamford, K. B., Collins, J. S. A., Bickley, J., Johnston, B. T., Potts, S., Boston, V., Owen, R. J., Sloan, J., Basso, L., Lawlor, S., Clune, J., Szelényi, H., Stohmeyer, G., Macedo, G., Iglésias, I., Chaves, A. P., Loureiro, A., Katelaris, P. H., Seow, F., Lin, B., Napoli, J., Hones, D. B., Ngu, M. C., Akopyantz, Natalia S., Bukanov, Nikolay O., Westblom, T. Ulf, Berg, Douglas E., Nyst, J. F., Denis, P., Buset, M., De Reuck, M., Nielsen, H., Andersen, L. P., Birkholz, Sabine, Knipp, Ulrich, Nietzki, Claudia, Opferkuch, Wolfgang, Crabtree, J. E., Peichl, P., Lindly, I. J. D., Deusch, K., Seifirth, C., Funk, A., Dahie, I., Reut, K., Classen, M., Gionchetti, P., Vaira, D., Campieri, M., Bertinelli, E., Menegatti, M., Belluzzi, A., Briognola, C., Miglioli, M., Barbara, L., Tommaso, A. Di, Magistris, M. T. De, Bugnoli, M., Petracca, R., Covacci, A., Censini, S., Rappuoli, R., Abrignani, S., Territo, M. C., Smela, K. L., Reeve, J. R., Lee, T. D., Walsh, J. H., Armellini, D., Crabtree, J. E., Xiang, Z. Y., Mitchell, H. M., Hu, P. J., Li, Y. Y., Wang, Z. J., Zhao, S. M., Liu, Q., Chen, M., Du, G. G., Filipe, M. I., Reed, P. I., Craanen, M. E., Blok, P., Dekker, W., Colombo, E., Redaelli, D., Santangelo, M., Spinelli, M., Farinati, F., Valiante, F., Delia Libera, G., Germanà, B., Baffa, R., Rugge, M., Vianelo, F., Di Mario, F., Sipponen, Pentti, Rokkas, T., Popotheodorou, G., Kaldgeropoulos, N., Deprez, C., Galand, P., Fox, J. G., Wishnok, P., Murphy, J. C., Tannenbaum, S., Correa, P., Parsonnet, Julie, Macor, C., Da Broi, G. L., Avellinio, C., Reifen, R., Rasooly, I., Millson, M. E., Murphy, K., Thomas, J. E., Eastham, E. J., Malorgio, E., Dell’Olio, D., Kemmer, T. P., Dominguez-Munoz, J. E., Klingel, H., Gatto, M. R. A., Olivieri, R., Bayeli, R. F., Abate, L., De Gregorio, L., Aziz, J., Esposito, E., Basagni, C., Guilluy, R., Rousseau-Tsangaris, M., Brazier, J. L., Wadstiöm, Torkel, Tyszkiewicz, Tadeusz, Bergenzaun, Per, Olsson, Karin, Birac, C., Tall, F., Albenque, M., Labigne, A., Megraud, F., Feldman, R. A., Deeks, J., Glupczynski, Y., Burette, A., Goossens, H., Van den Boore, C., Butzler, J. P., Veldhuyzen van Zanten, S., Best, L., Benzanson, G., Haldane, D., Hazell, S., Mapstone, N. P., Lynch, D. A. F., Quirke, P., Taylor, D. E., Chang, N., Eaton, M., Stockdale, E., Salama, S. M., Thompson, L., Cockayne, A., Spiller, R. C., Leen, E., Sweeney, E., Klann, H., Hatz, R., Bornschein, W., Simon, T., Eimiller, A., Bolle, F., Schweikert, C., Köpeke, W., Moss, S. F., Bishop, A. E., Calam, J., Cahill, R. J., Xia, H., Solnick, J., and Tompkins, L.

Published
1992
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7. VIe Symposium International d’Endoscopie Digestive

Author

Buset, M., Baize, M., Dez Marez, B., Bourgeois, N., De Boelpaepe, C., De Toeuf, J., Cremer, M., Cusumano, A., Norberto, L., Martella, B., Buin, F., Aneona, E., Lambert, R., Spinelli, P., Dal Fants, M., Rey, J. F., Greff, M., Brunetaud, J. M., Maunoury, V., Mudry, J., Paris, C., Rutgeerts, P., Geboes, K., Philippeth, L., Broeckaert, L., Coremans, G., Vantrappen, G., Dunham, F., Marlière, Ph., Gulbis, A., Reeders, Jacques, Tytgat, Guido, Maratka, Zdenek, Rozen, P., Deltenre, M., De Reuck, M., Jonas, C., Burette, A., Bidart, J. M., Castro, R., Laurent, J. X., Verdier, A., Vicari, F., Stessens, L., Van den Oord, J., De Wolf-Peeters, G., Ponette, S., Van Meerhaeghe, X., Van Ganse, W., Ghillebert, G., Vanneste, A., Meessen, J. P., Mourin-Jouret, A., Jungers, M., Haot, J., Vanheuverzwyn, R., Rossoni, R., Polito, D., Oselladore, D., Stevanato, G., Pincione, F., Vinciguerre, G., Troiani, R., Lombardi, M., Dell’Amico, I., Ambrogi, M., Sicari, A., Farella, S., Cola, B., Mortilla, M. G., Giardino, R., Franchini, A., Dell’ Anna, A., Neri, A., Piccione, M., Ferrara, M., Miscusi, G., Lemper, J C, Laurent, P, Morobe, J, Van Laethem, A, Risa, L., Masoni, L., Janssens, J., Laporta, T., Soehendra, N., Kempeneers, I., Van Gossum, M., Osmani, A., Van Gossum, A., Costamagna, G., Montori, A., Buecino, R. V., Ciolfi, F., Masi, V., Gilbert, D., Hallstrom, A., Silverstein, F., Shaneyfelt, S., Aertsen, P., Sahel, J., Sarles, H., Deviere, J., Gulbis, B., Delhaye, M., Adler, M., Depelchin, P., Philippart, Y., Quenon, M., Russo, A., Giannone, G., Delvaux, M., Escourrou, J., Senegas-Balas, F., Balas, D., Bastié, M J., Bertrand, C., Ribet, A., Van der Spek, P., Espeel, M., Cornelis, A., Roels, F., Dino, Amadori, Alberto, Ravaioli, Marilena, Liverani, Ruggero, Riflolfi, Debongnie, J. C., Legros, G., Beyaert, C., Cora, G. A., Peracchia, A., Cristallini, E., Fatale, G. P., Ribacchi, R., Barberani, F., Delia Spoletina, A., Rossi, P., Carpinelli, D., Fontaniére, B., Faucon, K., Mayer, M., Papillon, J., Labadie, M., Berger, F., Liaras, A., Bret, Pa., Bretagnolle, M., Fond, A., Minaire, Y., Bouvet, B., Tribukait, Bernhard, Lamouliatte, H., Bondonny, J. M., and Battin, J.

Published
1985
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10. Abstracts

Author

Gulbis A., Dunham F., Deltenre, M., Burette, A., de Reuck, M., Drabs, Ph., Jonas, C., Izquierdo, F., Marti, J., Zaragozano, R., Pereiro, M., Vicente-Rodríguez, J., Arañô, P., Valdivia, J. G., Romero, F., Rosa, J., Sánchez Santos, J. A., Jiménez-Cruz, J. F., Beamud, A., Boronat, F., Mompo, J. A., Boronat, F., Gallego, J., Alonso, M., Guillén, M., Llopis, B., Jiménez-Cruz, J. F., Vicente-Rodríguez, J., Algaba, F., Valls, F., Martínez, R., Prosper, F., Mareno, B., Fernández, J., Iranzo, S., Alonso, M., Oliver, F., Obaidat, F., Morer, F., Viscasillas, P., Rajmil, H. O., Vicente-Rodríguez, J., Puigvert, F., Ginecología, S., Valdivia, J. G., Elizalde, A., López, J. A., Izquierdo, F., Villarroya, S., Aguiló, R., Moya, J., Morera, R., Saumench, J., Ferrer, G., Alberti, A., Pac, J., Cantó, A., Pac, J., Moya, J., Rivas, J., Wittmoser Raymond, Sastre, V. Font, Casellas, J. Carabias, Sastre, V. Font, Montiel, X. Saura, Alcalde, R. P., Abadal, J., Baños, F., Miró, S., Canueva, A., Vázquez-Iglesias, J. L., Castro, J., Lorenzo, A., Debén, A. G., Rodríguez, J. M., Arnal, F., Pérez Piqueras, J., Moreno Muro, M., Moreno Vara, J., Serrano Martínez, R., Abad Vallejo, J., Gutiérrez Pérez, J. A., Santa Valiente, J. M., Díaz Lobón, J. M., Peñaloza, Arecio, Piña, R., Tulena, E., Garavito, J., Llorens, P., Altschiller, H., Bañados, G., Pisano, R., Goldin, L., Scheinwald, G., Moya, P., Levy, I., Barrios, P., Borrell, J., Barri, J., Piñol, J., Sala, J., Paniagua Estévez M., Jiménez Mesa G., González Lazo N., Menckén, P., Senent, C., Clémente, G., Pérez de Ayala, V., Castellanos, D., Aldequer, M., Torres, J., Rabago, L., Alcalá Santaella, R., Russo, A., Jung, M., Meier, H. J., Mennicken, C., Manegold, B. C., Grá Oramas, B., Casanueva, A., Enríquez, A., Robres, A., Camacho, P., Pistoia, M. A., Amicucci, G., Guadagni, S., Pistoia, F., Resta, V., Paolini, M. R., De Petris, G., Bultrini, F., Pizzuti, G., Clemente, G., Lara, V. G., Calabrese, M., Ranalletta, D., Poscente, A., Massucci, G., Gossetti, F., Durana, J., Arijón, J., Valbuena, L., Forteza, J., Guiteras Val, Jordi, Varas Lorenzo, M. J., Manchón, A., López Moreno, J. L., Alegre, J., Ferrando, J., Reig, G., Moreno, E., García-Conde, J., Rey, J. F., Greff, M., Maupetit, P., Pereira, S., Soto, A., Bordas, J. M., Mondelo, F., Heredia, D., Vilar, J., Fuster, F., Viola, C., Peláez, G., Rodés, J., Van Gossum, M., Delfosse, Jacques, Sommelet, Jean, and Coudane, Henry

Published
1984
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18. 711 HEPATITIS B VIRUS (HBV) INFECTION IN BELGIUM: RESULTS OF THE BELGIAN ASSOCIATION FOR THE STUDY OF THE LIVER (BASL) REGISTRY OF 1421 HBSAG CHRONIC CARRIERS

Author

Deltenre, P., primary, Laleman, W., additional, van Gossum, M., additional, Lenaerts, A., additional, Colle, I., additional, Adler, M., additional, Michielsen, P., additional, Assene, C., additional, Delwaide, J., additional, Orlent, H., additional, Reynaert, H., additional, D'Heygere, F., additional, Langlet, P., additional, Robaeys, G., additional, de Galocsy, C., additional, Brenard, R., additional, Sprengers, D., additional, Mairlot, M.-C., additional, Preux, C., additional, Lefèbvre, V., additional, and Henrion, J., additional

Published
2010
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25. A regular screening for hepatitis delta virus among chronic hepatitis B carriers improves the diagnostic of this infection and of subsequent cirrhosis development.

Author

Weichselbaum L, Njimi H, van den Wijngaert S, Dahma H, Nkuize M, Van Gossum M, Eisendrath P, Mulkay JP, and Sersté T

Subjects
Humans, Male, Female, Middle Aged, Adult, RNA, Viral blood, Coinfection diagnosis, Disease Progression, Hepatitis Antibodies blood, Prevalence, Elasticity Imaging Techniques, Aged, Incidence, Liver Cirrhosis virology, Liver Cirrhosis diagnosis, Hepatitis Delta Virus genetics, Hepatitis Delta Virus immunology, Hepatitis Delta Virus isolation & purification, Hepatitis B, Chronic complications, Hepatitis B, Chronic diagnosis, Hepatitis B, Chronic virology, Hepatitis D diagnosis, Hepatitis D complications, Hepatitis D epidemiology, Hepatitis B Surface Antigens blood, Mass Screening methods, Carrier State diagnosis
Abstract

Background and Objective: The prevalence of Hepatitis Delta Virus (HDV) is underestimated and the assessment of fibrosis is recommended for this infection. We tested the diagnostic impact of an annual screening for HDV serology in Hepatitis B Surface Antigen (HBs Ag) chronic carriers and followed the progression of fibrosis in these patients., Methods: Between January 2014 and October 2021, we annually tested all chronic HBs Ag-positive patients for HDV antibody (HDV Ab). Each HDV Ab positive patient underwent annually repeated elastometry. Patients with detectable HDV RNA levels (group 1) were compared to those with undetectable HDV RNA (group 2)., Results: We identified 610 chronic HBs Ag-positive patients, and repeated screening for HDV Ab was performed in 534 patients. Sixty (11%) patients were HDV Ab positive at baseline and were considered as "coinfected". Seven cases of HDV superinfection were diagnosed through repeated screening. In co-infected patients, cirrhosis was initially diagnosed in 12/60 patients and developed in six patients during follow-up. HDV RNA PCR was performed in 57/67 patients and 27 had detectable levels (group 1). Cumulative incidence of cirrhosis at 7 years was 13.8% (95% CI 0-30) in group 1 and 0 (95% CI 0-0) in group 2 (p = 0.026)., Conclusion: A systematic screening for HDV in chronic HB Ag carriers revealed a high prevalence of HDV Ab. Repeated serological screening enables the diagnosis of superinfections in asymptomatic patients. Regular assessment of fibrosis using elastometry leads to the identification of incidental cirrhosis in patients with detectable HDV RNA., (© 2024 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology.)

Published
2024
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26. Side-to-side magnet anastomosis system duodeno-ileostomy with sleeve gastrectomy: early multi-center results.

Author

Gagner M, Cadiere GB, Sanchez-Pernaute A, Abuladze D, Krinke T, Buchwald JN, Van Sante N, Van Gossum M, Dziakova J, Koiava L, Odovic M, Poras M, Almutlaq L, and Torres AJ

Subjects
Adult, Humans, Female, Male, Magnets, Duodenum surgery, Anastomosis, Surgical methods, Obesity surgery, Gastrectomy methods, Weight Loss, Retrospective Studies, Diabetes Mellitus, Type 2 surgery, Obesity, Morbid surgery, Gastric Bypass methods
Abstract

Introduction: Gastrointestinal anastomoses with classical sutures and/or metal staples have resulted in significant bleeding and leak rates. This multi-site study evaluated the feasibility, safety, and preliminary effectiveness of a novel linear magnetic compression anastomosis device, the Magnet System (MS), to form a side-to-side duodeno-ileostomy (DI) diversion for weight loss and type 2 diabetes (T2D) resolution., Methods: In patients with class II and III obesity (body mass index [BMI, kg/m 2 ] ≥ 35.0- ≤ 50.0 with/without T2D [HbA1C > 6.5%]), two linear MS magnets were delivered endoscopically to the duodenum and ileum with laparoscopic assistance and aligned, initiating DI; sleeve gastrectomy (SG) was added. There were no bowel incisions or retained sutures/staples. Fused magnets were expelled naturally. Adverse events (AEs) were graded by Clavien-Dindo Classification (CDC)., Results: Between November 22, 2021 and July 18, 2022, 24 patients (83.3% female, mean ± SEM weight 121.9 ± 3.3 kg, BMI 44.4 ± 0.8) in three centers underwent magnetic DI. Magnets were expelled at a median 48.5 days. Respective mean BMI, total weight loss, and excess weight loss at 6 months (n = 24): 32.0 ± 0.8, 28.1 ± 1.0%, and 66.2 ± 3.4%; at 12 months (n = 5), 29.3 ± 1.5, 34.0 ± 1.4%, and 80.2 ± 6.6%. Group mean respective mean HbA1 C and glucose levels dropped to 1.1 ± 0.4% and 24.8 ± 6.6 mg/dL (6 months); 2.0 ± 1.1% and 53.8 ± 6.3 mg/dL (12 months). There were 0 device-related AEs, 3 procedure-related serious AEs. No anastomotic bleeding, leakage, stricture, or mortality., Conclusion: In a multi-center study, side-to-side Magnet System duodeno-ileostomy with SG in adults with class III obesity appeared feasible, safe, and effective for weight loss and T2D resolution in the short term., (© 2023. The Author(s).)

Published
2023
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27. Premedication with simethicone for improving the quality of gastric mucosal visualization: a double-blind randomized controlled trial.

Author

Duez L, Gkolfakis P, Bastide M, Vuckovic C, Musala C, Van Gossum M, Hoyois A, Mulkay JP, and Eisendrath P

Abstract

Background and study aims  Saliva, bubbles, or mucus can limit gastric mucosal visualization (GMV), increasing the risk of missed lesions such as gastric cancer. Several studies using endoscopy photodocumentation-based scores have reported increased quality of GMV when mucolytic and/or defoaming agents are administered. This single-center, prospective, double-blind, randomized, placebo-controlled trial aimed to evaluate whether simethicone administration could improve GMV. Patients and methods  Patients were randomly assigned (1:1) to receive either 200 mg of simethicone (Group A) or placebo (Group B). Two independent endoscopists reviewed the entire video recording from each examination to assess the quality of GMV. The primary outcome was the rate of adequate GMV, defined as the percentage of patients in each group with a video score scale < 7 based on gastric visualization of five gastric landmarks. Secondary outcomes included procedure duration, patient satisfaction, and side effects. Results  A total of 110 consecutive outpatients were randomly assigned to one of the two study groups (11 were excluded for various reasons). For the primary endpoint, 32 patients (61.5 %) in group A achieved adequate GMV compared to one of 47 (2.1 %) in group B (odds ratio [95 % confidence interval]: 73.6 [9.4-576.6]; P  < 0.001). Median procedure time did not differ between the groups ( P  = 0.55), and no differences were detected in patient satisfaction ( P  = 0.18) or side effects ( P  = 0.58). No serious adverse events were documented. Conclusions  Premedication with simethicone before upper gastrointestinal endoscopy significantly improves the quality of GMV without affecting the duration of the examination, patient satisfaction, and the rate of side effects., Competing Interests: Competing interests The authors declare that they have no conflict of interest., (The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).)

Published
2022
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29. Efficacy of vedolizumab for induction of clinical response and remission in patients with moderate to severe inflammatory bowel disease who failed at least two TNF antagonists.

Author

De Vos M, Dhooghe B, Vermeire S, Louis E, Mana F, Elewaut A, Bossuyt P, Baert F, Reenaers C, Van Gossum M, Macken E, Ferrante M, Hindryckx P, Dewit O, Holvoet T, and Franchimont D

Abstract

Background: Vedolizumab is a recently available monoclonal antibody targeting α4β7 integrin for the treatment of ulcerative colitis (UC) and Crohn's disease (CD)., Objective: The objective of this article is to evaluate the efficacy of vedolizumab induction therapy in anti-TNF-refractory/intolerant UC and CD patients in real life., Methods: A cohort of 149 moderately to severely active UC and CD patients who failed or showed intolerance to at least two TNF antagonists participated in a medical need program and received vedolizumab in 37 Belgian centers (April-September 2015). Rates of clinical response and remission were retrospectively evaluated at Week 10 for UC and Week 14 for CD using the physician's global assessment (PGA), Mayo score and Harvey Bradshaw index (HBI) or Crohn's disease activity score (CDAI) scores., Results: Eighty-four patients (29 UC, 55 CD) had sufficient data for analysis. For UC patients, clinical response was observed in 76% based on PGA and 59% based on the Mayo score. The corresponding percentages for CD patients were 80% for PGA and 65% for HBI/CDAI. Clinical remission rates were 10% and 40% for UC and CD, respectively. Steroid-free remission was observed in respectively 10% and 35%. Globally, corticosteroids were stopped in 14 out of 48 patients (29%). No new safety signals were reported., Conclusion: Up to 70% TNF-refractory/intolerant UC and CD patients achieved a clinical response after 10 to 14 weeks of vedolizumab treatment in this real-life cohort.

Published
2018
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30. Transanal Minimally Invasive Anal Canal Polyp Resection.

Author

Dapri G, Fabres AC, Nicod O, Rodrigo GD, Muls V, and Van Gossum M

Subjects
Adult, Anal Canal diagnostic imaging, Female, Humans, Intestinal Mucosa pathology, Intestinal Polyps diagnosis, Anal Canal surgery, Endoscopic Mucosal Resection methods, Intestinal Mucosa surgery, Intestinal Polyps surgery, Natural Orifice Endoscopic Surgery methods, Surgical Flaps
Abstract

Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are operative endoscopies that have been performed since a long time. Recently, an evolution of laparoscopy called transanal minimally invasive surgery began to be popularized, and it can be adopted in the face of difficult cases for EMR/ESD. In this video, a 36-year-old woman was submitted to transanal minimally invasive surgery resection, after unsuccessful ESD, for a 2-cm polyp located anteriorly in the anal canal, just beyond the pectineal line. Preoperative workup showed a uT1m versus T1sm N0 M0 lesion. The procedure was performed with a new reusable transanal platform and a monocurved coagulating hook and grasping forceps. The operative time was 90 minutes. No perioperative complications were registered, and the patient was discharged on postoperative day 1. The pathologic report showed a villotubular adenoma with high-grade dysplasia and distant-free margins. After 1 year, the patient was going well, without any recurrent disease. Transanal minimally invasive surgery resection is a good alternative to conventional endoscopic therapies, allowing a meticulous dissection under the magnified operative field's exposure, and a mucosal-submucosal flap closure under satisfactory surgeon's ergonomics.

Published
2018
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31. Alcohol intake increases the risk of HCC in hepatitis C virus-related compensated cirrhosis: A prospective study.

Author

Vandenbulcke H, Moreno C, Colle I, Knebel JF, Francque S, Sersté T, George C, de Galocsy C, Laleman W, Delwaide J, Orlent H, Lasser L, Trépo E, Van Vlierberghe H, Michielsen P, van Gossum M, de Vos M, Marot A, Doerig C, Henrion J, and Deltenre P

Subjects
Alcohol Drinking, Ethanol, Hepacivirus, Hepatitis B, Hepatitis C, Humans, Liver Cirrhosis, Prospective Studies, Risk Factors, Carcinoma, Hepatocellular, Liver Neoplasms
Abstract

Background & Aims: Whether alcohol intake increases the risk of complications in patients with HCV-related cirrhosis remains unclear. The aim of this study was to determine the impact of alcohol intake and viral eradication on the risk of hepatocellular carcinoma (HCC), decompensation of cirrhosis and death., Methods: Data on alcohol intake and viral eradication were prospectively collected in 192 patients with compensated HCV-related cirrhosis., Results: 74 patients consumed alcohol (median alcohol intake: 15g/day); 68 reached viral eradication. During a median follow-up of 58months, 33 patients developed HCC, 53 experienced at least one decompensation event, and 39 died. The 5-year cumulative incidence rate of HCC was 10.6% (95% CI: 4.6-16.6) in abstainers vs. 23.8% (95% CI: 13.5-34.1) in consumers (p=0.087), and 2.0% (95% CI: 0-5.8) vs. 21.7% (95% CI: 14.2-29.2) in patients with and without viral eradication (p=0.002), respectively. The lowest risk of HCC was observed for patients without alcohol intake and with viral eradication (0%) followed by patients with alcohol intake and viral eradication (6.2% [95% CI: 0-18.4]), patients without alcohol intake and no viral eradication (15.9% [95% CI: 7.1-24.7]), and patients with alcohol intake and no viral eradication (29.2% [95% CI: 16.5-41.9]) (p=0.009). In multivariate analysis, lack of viral eradication and alcohol consumption were associated with the risk of HCC (hazard ratio for alcohol consumption: 3.43, 95% CI: 1.49-7.92, p=0.004). Alcohol intake did not influence the risk of decompensation or death., Conclusions: Light-to-moderate alcohol intake increases the risk of HCC in patients with HCV-related cirrhosis. Patient care should include measures to ensure abstinence., Lay Summary: Whether alcohol intake increases the risk of complications in patients with HCV-related cirrhosis remains unclear. In this prospective study, light-to-moderate alcohol intake was associated with the risk of hepatocellular carcinoma in multivariate analysis. No patients who did not use alcohol and who reached viral eradication developed hepatocellular carcinoma during follow-up. The risk of hepatocellular carcinoma increased with alcohol intake or in patients without viral eradication and was highest when alcohol intake was present in the absence of viral eradication. Patients with HCV-related cirrhosis should be strongly advised against any alcohol intake. Patient care should include measures to ensure abstinence., (Copyright © 2016 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.)

Published
2016
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32. Factors associated with vitamin D deficiency in a population of 2044 HIV-infected patients.

Author

Theodorou M, Sersté T, Van Gossum M, and Dewit S

Subjects
Adult, Aged, Aged, 80 and over, Alkynes, Benzoxazines therapeutic use, CD4 Lymphocyte Count, Cyclopropanes, Female, HIV Infections blood, HIV Infections complications, Humans, Male, Middle Aged, Prevalence, Retrospective Studies, Risk Factors, Viral Load, Vitamin D blood, Vitamin D Deficiency blood, Vitamin D Deficiency complications, Young Adult, HIV Infections epidemiology, Vitamin D Deficiency epidemiology
Abstract

Background and Aims: The high prevalence of vitamin D deficiency in HIV-infected patients has been demonstrated but there are still controversies regarding to the role of antiretroviral therapy (ART) in this setting. The aims of this study was to validate factors associated with vitamin D deficiency in a large cohort of HIV-infected patients., Methods: A retrospective analysis of 2044 consecutive patients from December 2005 to March 2011 was conducted. Factors independently associated with vitamin D deficiency (<30 ng/ml and <10 ng/ml) were analyzed. Vitamin D levels were compared according to CD4 count, viral load and ART modalities., Results: vitamin D was <30 ng/ml in 89.2% and <10 ng/ml in 32.4%. The median value was 13.8 ng/ml (4-102). Winter season, female sex, heterosexual acquisition of HIV, the need of second lines (complex and sequential treatment modalities) and a longer duration of ART were independently associated with vitamin D deficiency (<30 ng/ml). CD4 count <200/μl, advanced stages of disease and the current efavirenz use were independently associated with severe vitamin D deficiency (<10 ng/ml). Median vitamin D levels was 14.1 ng/dl when CD4 ≥200/μl, 11.5 ng/dl when CD4<200 (p = 0.0003). The ART modalities had a significant influence on vitamin D concentrations, the highest vitamin D level was observed in the absence of treatment., Conclusions: In HIV-infected patients, vitamin D deficiency is associated with ART modalities and duration. The most severe vitamin D deficiencies are associated with low CD4 count, the use of efavirenz and advanced stages of disease severity., (Copyright © 2013 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.)

Published
2014
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33. Hepatitis B virus and hepatitis C virus infections in Belgium: similarities and differences in epidemics and initial management.

Author

De Vroey B, Moreno C, Laleman W, van Gossum M, Colle I, de Galocsy C, Langlet P, Robaeys G, Orlent H, Michielsen P, Delwaide J, Reynaert H, D'Heygere F, Sprengers D, Bourgeois S, Assene C, Vos B, Brenard R, Adler M, Henrion J, and Deltenre P

Subjects
Adult, Age Factors, Alanine Transaminase blood, Antiviral Agents therapeutic use, Belgium epidemiology, Biomarkers blood, Biopsy, Carrier State epidemiology, Epidemics, Female, Hepatitis B diagnosis, Hepatitis B drug therapy, Hepatitis B transmission, Hepatitis B Surface Antigens blood, Hepatitis B virus physiology, Hepatitis C diagnosis, Hepatitis C drug therapy, Hepatitis C transmission, Humans, Liver pathology, Male, Middle Aged, Registries, Risk Factors, Sex Factors, Viral Load, Virus Replication, Hepatitis B epidemiology, Hepatitis C epidemiology
Abstract

Introduction: Nationwide studies comparing patients with hepatitis B and C virus (HBV and HCV) infections are mandatory for assessing changes in epidemiology., Aim: The aim of this study was to compare epidemiological data and initial management of newly diagnosed patients with persistent HBV (HBsAg positive) or HCV (detectable HCV RNA) infection in Belgium., Patients and Methods: Data were extracted from two Belgian observational databases., Results: A total of 655 patients (387 HBV and 268 HCV) were included. Compared with HCV patients, HBV patients were younger, more frequently men, more often of Asian or African origin (43 vs. 10%, P<0.0001), and less frequently contaminated by transfusion or intravenous drug use (9 and 6% vs. 34 and 44%, P<0.0001). Viral replication was assessed in 89% of HBV patients. Compared with HCV patients, HBV patients more frequently had normal alanine aminotransferase (ALT) levels (65 vs. 29%, P<0.0001), less frequently underwent liver biopsy (29 vs. 67%, P<0.0001), and were less often considered for antiviral therapy (25 vs. 54%, P<0.0001). When taking only HBV patients with detectable viral replication into consideration, results remained unchanged. During the multivariate analysis, ALT was a major factor for performing liver biopsy or considering antiviral therapy in both groups., Conclusion: HBV and HCV screening policies should be targeted toward immigrants and intravenous drug users, respectively. Guidelines recommending systematic search for viral replication should be reinforced in HBV patients. HBV patients less frequently underwent liver biopsy and were less often considered for antiviral therapy compared with HCV patients. Despite the lack of sensitivity and specificity, ALT remains a pivotal decision-making tool for liver biopsy and antiviral therapy in both infections.

Published
2013
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34. [Dysphagia and recurrent esophageal stenosis associated with intramural pseudodiverticulosis of the esophagus. A case report].

Author

Ifrim D, Rickaert F, and Van Gossum M

Subjects
Aged, Humans, Male, Recurrence, Deglutition Disorders etiology, Diverticulosis, Esophageal diagnosis, Esophageal Stenosis etiology
Abstract

Intramural pseudodiverticulosis of the esophagus is a rare benign disease of the eosphageal wall, with dilation of the submucosal glands, and the predominant symptom is dysphagia. This disorder may be associated with gastroesophageal reflux, motility disorders, candidiasis and alcoholism. Inflammation, resulting in periductal fibrosis and compression of the duct orifices, may be a causative factor. Good and long-lasting therapeutic success can be achieved by bouginage of the stenosis with concomitant treatment of the associated esophageal diseases. Esophageal intramural pseudodiverticulosis is a differential diagnosis in cases of dyspagia and/or esophageal strictures if no other causes are found.

Published
2010

35. Metabolic disorders associated with chronic hepatitis C: impact of genotype and ethnicity.

Author

Sersté T, Nkuize M, Moucari R, Van Gossum M, Reynders M, Scheen R, Vertongen F, Buset M, Mulkay JP, and Marcellin P

Subjects
Adult, Analysis of Variance, Arabs, Belgium epidemiology, Black People, Blood Pressure, Body Mass Index, Female, Genotype, Hepatitis C, Chronic genetics, Humans, Insulin Resistance, Male, Metabolic Diseases etiology, Middle Aged, White People, Hepacivirus genetics, Hepatitis C, Chronic complications, Metabolic Diseases epidemiology, Metabolic Diseases ethnology
Abstract

Background & Aim: Patients with hepatitis C virus (HCV) infection, especially those with genotypes 1 and 4, have an increased risk of developing metabolic disorders. The aim of this study was to evaluate the associations among metabolic disorders, ethnicity and genotype in a large cohort of patients with chronic hepatitis C (CHC)., Patients and Methods: All consecutive patients with CHC who were seen in our hepato-gastroenterology unit between January 2002 and September 2008 were included. Demographical data and variables related to the metabolic syndrome were collected. Insulin resistance was assessed using the homeostasis model for the assessment of insulin resistance test (HOMA-IR) test., Results: Among the 454 CHC patients, the prevalence of the metabolic syndrome was 12.4%. The HOMA-IR test was performed in 140 patients, and 35.0% had insulin resistance. There were more Black Africans among the patients with genotypes 1/4 than among those with genotypes 2/3 (32.0 vs 1.2%, P<0.0001). Insulin resistance was more common in patients with genotypes 1/4 than in those with genotypes 2/3 (17 vs 1.7%, P=0.0001 and 43.3 vs 16.3%, P=0.001, respectively). Genotypes 1/4 were more frequently present in patients with insulin resistance than in those without insulin resistance (85.7 vs 60.5%, P=0.001). By logistic regression, genotypes 1/4 [odds ratio (OR)=2.79; 95% confidence interval (CI): 1.09-7.12, P=0.032] and older age (OR=1.03; 95% CI: 1.004-1.06, P=0.024) were independently associated with the presence of insulin resistance., Conclusions: In CHC, insulin resistance is independently associated with the presence of genotypes 1/4. Ethnicity is not independently associated with metabolic disorders in patients with CHC.

Published
2010
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36. [Autoimmune hepatitis and CREST syndrome].

Author

Ngo Mandag N, Van Gossum M, Rickaert F, and Golstein M

Subjects
Azathioprine therapeutic use, CREST Syndrome drug therapy, Female, Hepatitis, Autoimmune drug therapy, Humans, Immunosuppressive Agents therapeutic use, Jaundice drug therapy, Middle Aged, Prednisolone therapeutic use, CREST Syndrome complications, Hepatitis, Autoimmune complications, Jaundice complications
Abstract

We report the case of an autoimmune hepatitis in a 59-year old woman who was referred for a progressive jaundice. The patient had an history of CREST syndrome. The particularity of this case report is the rare association between these two autoimmune diseases.

Published
2007

37. Treatment of acute hepatitis C with interferon alpha-2b: early initiation of treatment is the most effective predictive factor of sustained viral response.

Author

Delwaide J, Bourgeois N, Gérard C, De Maeght S, Mokaddem F, Wain E, Bastens B, Fevery J, Géhénot M, Le Moine O, Martinet JP, Robaeys G, Servais B, Van Gossum M, and Van Vlierberghe H

Subjects
Acute Disease, Adolescent, Adult, Female, Humans, Interferon alpha-2, Male, Middle Aged, Prospective Studies, Recombinant Proteins, Remission, Spontaneous, Risk Factors, Treatment Outcome, Viral Load, Antiviral Agents therapeutic use, Hepatitis C drug therapy, Interferon-alpha therapeutic use
Abstract

Aim: To evaluate the efficacy of early interferon alpha-2b in non-post-transfusion acute hepatitis C virus: a prospective study with historical comparison., Patients: Group A: 28 patients prospectively treated for acute hepatitis C virus with daily regimen of interferon 5 million units for 2 months. Group B: historical series of 16 patients with untreated acute hepatitis C virus., Results: There was no significant difference between the two groups with regard to gender, age, icterus, alanine aminotransferase, or genotypes. In group B, hepatitis spontaneously resolved in three of 16 (19%) patients (follow-up 1-7 years). In group A, 21 of 25 patients became sustained viral responders (75%; P = 0.0003 vs. group B). Factors include not predictive of sustained viral response: age, gender, sources of infection, presence of icterus, alanine aminotransferase peak, bilirubin peak, incubation period, presence of hepatitis C virus antibodies at presentation, or genotypes. The time from presentation to the start of therapy was, however, significantly shorter in sustained viral responders (43 +/- 31 days) than in relapsers or non-responders (88 +/- 52 days) (P = 0.016)., Conclusions: Early treatment of acute hepatitis C virus with interferon prevents chronicity. A short waiting time from presentation to treatment appears as the most relevant predictive factor for sustained response.

Published
2004
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38. Idiopathic colonic varices: an unusual cause of massive lower gastrointestinal hemorrhage.

Author

Van Gossum M, Reuss K, Moussaoui M, and Bourgeois V

Subjects
Follow-Up Studies, Humans, Male, Middle Aged, Time Factors, Colon blood supply, Gastrointestinal Hemorrhage etiology, Varicose Veins complications
Abstract

Varices of the entire colon are very rare. This rare cause of massive lower gastrointestinal hemorrhage is almost invariably associated with cirrhosis of the liver and consequent hypertension or portal venous obstruction. We report about a patient with massive lower gastrointestinal bleeding from extensive colonic varices. Despite extensive investigation and a follow-up of 3 years, the etiology of the colonic varices could not be determined. Only a few cases of apparent idiopathic (familial or non-familial) colonic varices have been described. Recognition of this abnormality is important, however, because colonic varices may be the cause of recurrent, frequently massive lower gastrointestinal hemorrhage. A misleading endoscopic diagnosis can lead to inappropriate biopsies, resulting in major bleeding.

Published
2000

39. [Lactose and gluten intolerance: which to suscept?].

Author

Van Gossum M, Mascart F, Rickaert F, Codden T, and Colonius V

Subjects
Barium Sulfate, Biopsy, Breath Tests, Celiac Disease blood, Celiac Disease complications, Celiac Disease epidemiology, Celiac Disease therapy, Colonic Diseases, Functional etiology, Contrast Media, Glutens, Humans, Hydrogen analysis, Lactose Intolerance blood, Lactose Intolerance complications, Lactose Intolerance epidemiology, Lactose Intolerance therapy, Prevalence, Risk Factors, Celiac Disease diagnosis, Lactose Intolerance diagnosis
Abstract

Lactose intolerance affects millions of people world-wide and should be suspected specially when evaluating gastrointestinal symptoms in ethnic populations in which it is prevalent. Fortunately, once a diagnosis is made, management is fairly straightforward. The authors discuss symptoms and methods of detection and offer their recommendations for helping patients with this common disorder. Coeliac disease is the end result of 3 processes that culminate in intestinal damage: genetic predisposition, environmental factors, and immunological based inflammation. Epidemiological studies based on serologic tests suggest that the prevalence of coeliac disease has been significantly underestimated. The classic sprue syndrome of steatorrhea and malnutrition may be less common than more subtle and often monosymptomatic presentations of the disease. The authors discuss the diagnostic criteria and the clinical utility of serologic tests.

Published
2000

40. [New viral hepatitis].

Author

Van Gossum M and Bourgeois V

Subjects
Acute Disease, Chronic Disease, Female, Hepatitis, Viral, Human diagnosis, Hepatitis, Viral, Human epidemiology, Hepatitis, Viral, Human therapy, Hepatitis, Viral, Human transmission, Humans, Male, Pregnancy, Prevalence, Hepatitis, Viral, Human virology
Abstract

Viral hepatitis are essentially caused by 5 types of viruses which differ in way of transmission and their evolution to chronicity or not. Like the virus causing hepatitis A, the E-virus-discovered en 1983-is a virus with oral-fecal transmission, responsible only for acute hepatitis which may be fulminant, notably in pregnant woman. Responsible for epidemics in Asia and Africa, the E-virus is nearly non-existent in our regions. Just like the B, C and D viruses, the G-virus is a RNA-virus with intravenous transmission. Notwithstanding a high prevalence, its pathogenic role remains hypothetical so that some hesitate to consider it as a virus causing clinical hepatitis. Etiological viral or non-viral agents for the cryptogenic hepatitis which can appear as acute, fulminant, post-transfusional or chronic illness, remain to be discovered.

Published
1997

41. Omeprazole-based antimicrobial therapies: results in 198 Helicobacter pylori-positive patients.

Author

Deltenre M, Jonas C, van Gossum M, Buset M, Otero J, and De Koster E

Subjects
Amoxicillin therapeutic use, Anti-Bacterial Agents therapeutic use, Anti-Ulcer Agents administration & dosage, Anti-Ulcer Agents adverse effects, Biopsy, Clarithromycin therapeutic use, Dyspepsia microbiology, Dyspepsia pathology, Endoscopy, Digestive System, Female, Follow-Up Studies, Helicobacter Infections complications, Helicobacter Infections pathology, Humans, Male, Middle Aged, Omeprazole administration & dosage, Penicillins therapeutic use, Peptic Ulcer microbiology, Peptic Ulcer pathology, Anti-Ulcer Agents therapeutic use, Drug Therapy, Combination therapeutic use, Dyspepsia drug therapy, Helicobacter Infections drug therapy, Helicobacter pylori, Omeprazole therapeutic use, Peptic Ulcer drug therapy
Abstract

Aim: To compare the efficacies of omeprazole-based antimicrobial therapies in Helicobacter pylori-positive patients., Patients and Methods: We report the results of seven therapeutic trials combining omeprazole, clarithromycin, amoxycillin, colloidal bismuth subcitrate and tinidazole in 198 patients (peptic ulcer disease/non-ulcerative dyspepsia, 137/61) to eradicate H. pylori infection. The diagnosis of infection was performed by Sydney system biopsies, compliance was checked after a pill count at the end of the treatment and eradication was assessed at least 4 weeks after the end of the treatment either by the Sydney system for peptic ulcer disease or the urease breath test for non-ulcerative dyspepsia., Results: When results were analysed on a protocol basis, the only significant difference in eradication (P = 0.006) was found between the total population of patients treated with amoxycillin-based combinations (27 eradications out of 48 patients) and those given a treatment that included clarithromycin (84 eradications out of 108). Forty-two patients (21%) dropped out either because of side effects (10 among patients taking clarithromycin and two taking amoxycillin) or because they were lost to follow-up (27 patients). Out of 64 patients with active ulcers, 43 (67%) were both H. pylori-negative and ulcer-free 4-8 weeks after the end of therapy, 12 out of 64 (19%) were ulcer-free but remained H. pylori-positive and nine out of 64 (14%) were H. pylori-positive and had active ulceration.

Published
1995

42. [Medical treatment of reflux peptic esophagitis: literature review].

Author

Van Gossum M

Subjects
Esophagitis, Peptic physiopathology, Gastric Acid metabolism, Gastroesophageal Reflux physiopathology, Gastroesophageal Reflux surgery, Humans, Mucous Membrane physiopathology, Esophagitis, Peptic drug therapy, Gastroesophageal Reflux drug therapy, Histamine H2 Antagonists therapeutic use
Abstract

Treatment of GO reflux and reflux oesophagitis should be based on pathophysiology, natural history, diagnostic assessment and patient expectations. Physiopathologically, GO reflux results from the balance between aggression and defence. The primary importance of motor and sphincters disturbances should make prokinetic drugs the treatment of choice; however, these drugs are unable to influence the inappropriate sphincter relaxation. The severity of symptoms and lesions is related to the duration of exposition of the oesophagus to pH < 4 explaining the superiority of omeprazole over the usual doses of H2RA. Since symptoms and lesions relapse frequently after treatment, long term prophylaxis, either by surgery or by drugs, is necessary. Comparing different therapeutic options is complicated by the absence of a precise definition of abnormal GO reflux or a gold standard; moreover, treatment results depend on the initial oesophagitis grade. Treatment will depend on the desired goal: to treat symptoms of lower grade oesophagitis or to heal lesions and prevent complications of high grade oesophagitis.

Published
1994

43. [Anorectal sexually transmissible diseases].

Author

Van Gossum M

Subjects
Chlamydia trachomatis isolation & purification, Female, Homosexuality, Humans, Male, Neisseria gonorrhoeae isolation & purification, Simplexvirus isolation & purification, Treponema pallidum isolation & purification, Anus Diseases microbiology, Rectal Diseases microbiology, Sexually Transmitted Diseases microbiology
Published
1993

44. [Anal and perianal lesions observed in subjects infected with HIV virus].

Author

Van Gossum M, Puy-Montbrun T, and Ganansia R

Subjects
Anus Neoplasms complications, Condylomata Acuminata complications, Female, Hemorrhoids complications, Humans, Lymphoma, Non-Hodgkin complications, Male, Sarcoma, Kaposi complications, AIDS-Related Opportunistic Infections complications, Acquired Immunodeficiency Syndrome complications, Anus Diseases complications
Published
1993

45. [Unusual form of esophagobronchial fistula in adults].

Author

Van Gossum M, Nemry C, David P, De Battice C, and Bricart R

Subjects
Bronchial Fistula congenital, Bronchial Fistula surgery, Esophageal Fistula congenital, Esophageal Fistula surgery, Humans, Male, Middle Aged, Radiography, Bronchial Fistula diagnostic imaging, Esophageal Fistula diagnostic imaging
Abstract

We describe the case of an adult patient with a benign congenital esophagobronchial fistula. The different types of congenital fistula without atresia or in H form are discussed. We formulate some hypotheses explaining the late occurrence of symptoms in a lesion present since the patient's birth.

Published
1991

46. Juxtapapillary duodenal diverticula: association with biliary stone disease.

Author

De Koster E, Denis P, Mante M, Otero J, Nyst J, Jonas C, Van Gossum M, De Reuck M, and Deltenre M

Subjects
Adolescent, Adult, Aged, Child, Cholangiopancreatography, Endoscopic Retrograde, Cholelithiasis diagnostic imaging, Diverticulum diagnostic imaging, Duodenal Diseases diagnostic imaging, Female, Humans, Male, Middle Aged, Cholelithiasis complications, Diverticulum complications, Duodenal Diseases complications
Abstract

In order to explore the relationship between duodenal diverticula and biliary stone disease, we reviewed 2231 endoscopic retrograde cholangio-pancreatography procedures. We found at least one juxtapapillary diverticulum per 239 patients (10.8%). The occurrence of duodenal diverticula increases with age. Patients with duodenal diverticula were older, had more gallbladder stones, more common bile duct stones, had undergone cholecystectomy more frequently, and experienced more frequently common bile duct stone recurrence after cholecystectomy. We thus confirm an association between the presence of diverticula of the second part of the duodenum, and biliary stone pathology, including gallbladder stones, common bile duct stones, and recurrent stones after cholecystectomy. We discuss the aetiopathogeny of this affection.

Published
1990

47. [Cirrhosis and cryoglobulinemia. Case report and review of the literature].

Author

Van Gossum M, Burette A, Dratwa M, Deroy G, and Deltenre M

Subjects
Cryoglobulinemia blood, Female, Glomerulonephritis etiology, Humans, Immunoglobulin G analysis, Immunoglobulin M analysis, Middle Aged, Purpura etiology, Cryoglobulinemia etiology, Liver Cirrhosis complications, Paraproteinemias etiology
Published
1982

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