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319 results on '"Van Gasse, Athina"'

10. Mast Cell Activation During Suspected Perioperative Hypersensitivity: A Need for Paired Samples Analysis

Author

Ebo, Didier G., De Puysseleyr, Leander P., Van Gasse, Athina L., Elst, Jessy, Poorten, Marie-Line van der, Faber, Margaretha A., Mertens, Christel, Van Houdt, Michel, Hagendorens, Margo M., Sermeus, Luc, Vitte, Joana, Moise, Michel, Garvey, Lene H., Castells, Mariana C., Tacquard, Charles, Mertes, Paul-Michel, Schwartz, Lawrence B., and Sabato, Vito

Published
2021
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22. Occupational cannabis exposure and allergy risks

Author

Decuyper, Ine Ilona, Van Gasse, Athina, Faber, Margaretha Antje, Mertens, Christel, Elst, Jessy, Rihs, Hans-Peter, Sabato, Vito, Lapeere, Hilde, Hagendorens, Margo, Bridts, Chris, De Clerck, Luc, and Ebo, Didier

Published
2019

27. IgE‐Mediated Mast Cell Responses to Rocuronium: A Matter of Protonation Status.

Author

Ebo, Didier G., Van Houdt, Michel, Beyens, Michiel, Toscano, Alessandro, Mertens, Christel, Van Gasse, Athina L., Bruhns, Pierre, Sabato, Vito, and Elst, Jessy

Subjects
MEDIAN (Mathematics), MAST cells, NEUROMUSCULAR blocking agents, BLOOD proteins, DRUG allergy, ROCURONIUM bromide, BICARBONATE ions
Abstract

The article in Clinical & Experimental Allergy discusses the importance of protonation status in IgE-mediated mast cell responses to rocuronium. The study found that acidification to pH 6.9 during stimulation may enhance degranulation in low responders but dampen responsiveness in high responders. The research highlights the need for individualized protocols in IgE-mediated drug allergy testing, emphasizing the impact of acidification on mast cell responsiveness to rocuronium under suboptimal protonation conditions. [Extracted from the article]

Published
2024
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30. Clinical practice of hereditary angioedema in Belgium: opportunities for optimized care

Author

Ebo, Didier Gaston, Van der Poorten, Marie Line M.M., Van Gasse, Athina Ludovica, Schrijvers, Rik, Hermans, Cédric, Bartiaux, M., Haerynck, Filomeen, Willekens, Julie, Lapeere, Hilde, Moutschen, Michel, Michel, Olivier, Sabato, Vito, Ebo, Didier Gaston, Van der Poorten, Marie Line M.M., Van Gasse, Athina Ludovica, Schrijvers, Rik, Hermans, Cédric, Bartiaux, M., Haerynck, Filomeen, Willekens, Julie, Lapeere, Hilde, Moutschen, Michel, Michel, Olivier, and Sabato, Vito

Abstract

Introduction: Hereditary angioedema (HAE) is a rare disorder characterized by unpredictable painful and potentially life-threatening swelling episodes. The international WAO/EAACI guideline on the diagnosis and management of HAE was recently updated and provides up-to-date guidance for the management of. In this paper, we assessed to what extent the Belgian clinical practice was aligned with the revised guideline, and whether there were opportunities to optimise Belgian clinical practice in HAE. Methods: We compared the updated international guideline for HAE with information we acquired on Belgian clinical practice, a Belgian patient registry and expert opinion analysis. The Belgian patient registry was developed with the involvement of eight Belgian reference centers for HAE patients. Eight Belgian experts, physicians in the participating centers, included patients in the patient registry and participated in the expert opinion analysis. Results: The main action points to further optimise the Belgian clinical practice of HAE are Work towards total disease control and normalize patients’ life by considering the use of new and innovative long-term prophylactic treatment options; (2) inform C1-INH-HAE patients about new long-term prophylactic therapies; (3) assure the availability of on-demand therapy for all C1-INH-HAE patients; (4) implement a more universally used assessment including multiple aspects of the disease (e.g. quality of life assessment) in daily clinical practice; and (5) continue and expand an existing patient registry to assure continued data availability on C1-INH-HAE in Belgium. Conclusions: In light of the updated WAO/EAACI guideline, five action points were identified and several other suggestions were made to optimise the Belgian clinical practice in C1-INH-HAE., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

32. A quarter of a century fundamental and translational research in perioperative hypersensitivity and anaphylaxis at the Antwerp university hospital, a Belgian Centre of Excellence of the World Allergy Organization

Author

Ebo, Didier G., primary, Vlaeminck, Nils, additional, van der Poorten, Marie-Line M., additional, Elst, Jessy, additional, Toscano, Alessandro, additional, Van Gasse, Athina L., additional, Hagendorens, Margo M., additional, Aerts, Sophie, additional, Adriaensens, Ine, additional, Saldien, Vera, additional, and Sabato, Vito, additional

Published
2023
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34. Repository to: Dual intracellular staining of CD154(CD40L) and cytokines at single cell level: a novel aid to document immediate hypersensitivity to amoxicillin

Author

Ebo Didier, G., Jessy, Elst, Christel, Mertens, Van Der Poorten Marie-Line, M., Van Gasse Athina, L., Van Houdt Michel, Hagendorens Margo, M., and Vito, Sabato

Abstract

Respository methods, tables and figures to "Dual intracellular staining of CD154(CD40L) and cytokines at single cell level: a novel aid to document immediate hypersensitivity to amoxicillin".&nbsp

Published
2023
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35. Mas-related G protein-coupled receptor MRGPRX2 in human basophils: Expression and functional studies

Author

Toscano, Alessandro, primary, Elst, Jessy, additional, Van Gasse, Athina L., additional, Beyens, Michiel, additional, van der Poorten, Marie-Line, additional, Bridts, Chris H., additional, Mertens, Christel, additional, Van Houdt, Michel, additional, Hagendorens, Margo M., additional, Van Remoortel, Samuel, additional, Timmermans, Jean-Pierre, additional, Ebo, Didier G., additional, and Sabato, Vito, additional

Published
2023
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37. Correspondence to "Basophil activation test as predictor of severity and threshold of allergic reactions to egg".

Author

Ebo, Didier G., Elst, Jessy, Van Gasse, Athina L., Mertens, Christel, and Sabato, Vito

Subjects
ALLERGIES, BASOPHILS, ACTIVATION energy, FOOD allergy, EGGS, PEANUT allergy
Abstract

The article discusses the basophil activation test (BAT) as a potential tool for diagnosing egg allergies. The authors acknowledge the benefits of the BAT in reducing the need for resource-intensive and potentially dangerous double-blind controlled food challenges (DBPCFCs). However, they emphasize the importance of methodological details and the correct interpretation of results when using the BAT. They also highlight the need to include non-responders in the calculation of test performance metrics to avoid bias. Overall, the authors suggest that studies reporting on the BAT should provide comprehensive information and consider these factors to ensure accurate and reliable results. [Extracted from the article]

Published
2024
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39. Drug provocation tests with hypnotics, opioids, and neuromuscular blocking agents in the diagnosis of suspected perioperative hypersensitivity

Author

van der Poorten, Marie-Line M., primary, Vlaeminck, Nils, additional, Van Pée, Julie, additional, Thiele, Niklas, additional, Smout, Kirsten, additional, Elst, Jessy, additional, Toscano, Alessandro, additional, Van Gasse, Athina L., additional, Hagendorens, Margo M., additional, Aerts, Sophie, additional, Adriaensens, Ine, additional, Sermeus, Luc A., additional, Garvey, Lene H., additional, Sabato, Vito, additional, and Ebo, Didier G., additional

Published
2022
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42. Mastocytosis and related entities: a practical roadmap

Author

Beyens, Michiel, primary, Elst, Jessy, additional, van der Poorten, Marie-Line, additional, Van Gasse, Athina, additional, Toscano, Alessandro, additional, Verlinden, Anke, additional, Vermeulen, Katrien, additional, Maes, Marie-Berthe, additional, Oude Elberink, J. N. G. Hanneke, additional, Ebo, Didier, additional, and Sabato, Vito, additional

Published
2022
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46. Establishing diagnostic strategies for cannabis allergy

Author

Toscano, Alessandro, primary, Elst, Jessy, additional, van der Poorten, Marie-Line, additional, Beyens, Michiel, additional, Heremans, Kevin, additional, Decuyper, Ine I., additional, Van Gasse, Athina L., additional, Mertens, Christel, additional, Van Houdt, Michel, additional, Hagendorens, Margo M., additional, Sabato, Vito, additional, and Ebo, Didier G., additional

Published
2022
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47. Drug provocation tests with hypnotics, opioids, and neuromuscular blocking agents in the diagnosis of suspected perioperative hypersensitivity

Author

van der Poorten, Marie Line M., Vlaeminck, Nils, Van Pée, Julie, Thiele, Niklas, Smout, Kirsten, Elst, Jessy, Toscano, Alessandro, Van Gasse, Athina L., Hagendorens, Margo M., Aerts, Sophie, Adriaensens, Ine, Sermeus, Luc A., Garvey, Lene H., Sabato, Vito, Ebo, Didier G., van der Poorten, Marie Line M., Vlaeminck, Nils, Van Pée, Julie, Thiele, Niklas, Smout, Kirsten, Elst, Jessy, Toscano, Alessandro, Van Gasse, Athina L., Hagendorens, Margo M., Aerts, Sophie, Adriaensens, Ine, Sermeus, Luc A., Garvey, Lene H., Sabato, Vito, and Ebo, Didier G.

Published
2022

48. Mast cell activation test:A new asset in the investigation of the chlorhexidine cross-sensitization profile

Author

Ebo, Didier G., Elst, Jessy, Moonen, Nele, van der Poorten, Marie-Line M., Van Gasse, Athina L., Garvey, Lene H., Bridts, Chris H., Mertens, Christel, Hagendorens, Margo M., Sabato, Vito, Ebo, Didier G., Elst, Jessy, Moonen, Nele, van der Poorten, Marie-Line M., Van Gasse, Athina L., Garvey, Lene H., Bridts, Chris H., Mertens, Christel, Hagendorens, Margo M., and Sabato, Vito

Abstract

Background Insights into the IgE cross-sensitization and possible cross-reactivity patterns of sera reactive to chlorhexidine (CHX) are still incomplete and are likely to benefit from a functional exploration using a passive mast cell activation test (pMAT). Therefore, we want to study whether the pMAT with CHX-specific IgE (sIgE) enables to depict effector cell degranulation in response to alexidine (ALX), octenidine (OCT) and/or polyhexamethylene biguanide (PHMB) indicative of cross-reactivity between these compounds and CHX. Methods Serum of 10 CHX-allergic patients, nine individuals with an isolated sIgE CHX and five healthy controls were included. Human cultured mast cells (MCs) were, before and after sensitization, challenged with CHX, ALX, OCT or PHMB. Degranulation was measured via quantification of upregulation of CD63. Results Mast cell responsiveness to ALX and OCT was demonstrable with 4/10 and 3/10 of the sera of CHX-allergic patients respectively. Percentage of degranulation varied between 12 and 34% for ALX-reactive MCs and between 4 and 22% for OCT-reactive MCs. No reactivity to ALX or OCT was demonstrable when using sera obtained from individuals with an isolated sIgE CHX or from healthy controls. Unlike CHX, ALX and OCT, PHMB turned out to be a direct MC activator via occupation of MRGPRX2. PHMB-reactive sIgEs were demonstrable in some patients with an isolated sIgE CHX but were unable to trigger PHMB-induced degranulation in MRGPRX2 knockdown MCs. Conclusion Mast cells constitute an attractive tool to explore cross-reactivity between structurally similar compounds. Along with the identification of safe alternatives for the individual patient, the pMAT can advance our insights into sIgE cross-reactivity patterns including assessment of molecules not yet approved for human use.

Published
2022

49. Reliability of Early and Late Testing for Suspected Perioperative Hypersensitivity

Author

van der Poorten, Marie Line M., Walschot, Mark, Faber, Margaretha, Elst, Jessy, Van Gasse, Athina L., De Puysseleyr, Leander, Mertens, Christel M., Hagendorens, Margo M., Garvey, Lene H., Sabato, Vito, Ebo, Didier G., van der Poorten, Marie Line M., Walschot, Mark, Faber, Margaretha, Elst, Jessy, Van Gasse, Athina L., De Puysseleyr, Leander, Mertens, Christel M., Hagendorens, Margo M., Garvey, Lene H., Sabato, Vito, and Ebo, Didier G.

Abstract

Background: The optimal timing of diagnostic testing for perioperative hypersensitivity (POH) remains unknown. It has been recommended that investigation is best carried out at least 4 to 6 weeks after the event. On the other hand, guidelines discourage the use of in vitro tests later than 3 years after the index reaction. Objective: This retrospective study aimed to assess the reliability of early and late skin tests (STs). It also attempted to verify whether discouraging late ex vivo and in vitro tests is substantiated. Methods: For the first aim, patients were stratified over three epochs: an early timing group, with investigations performed within 6 weeks; a recommended timing group, with tests performed between 6 weeks and 6 months; and a late timing group, tested later than 6 months after the event. For the second study purpose, we studied the reliability of specific IgE quantification and basophil activation test rocuronium within 6 weeks and after 3 years in patients who experienced an ST-proven POH to rocuronium. Results: A total of 677 patients were included. Based on a positive ST result, a causative agent was found in 74.2% of the early timing group, 62.6% of the recommended timing group, and 50% of the late timing group. A positive specific IgE for rocuronium or morphine was found in 80% of patients tested within 6 weeks, 63% of patients tested between 6 weeks and 3 years, and 50% of patients tested more than 3 years after the event. A positive basophil activation test was found in 83.3%, 51%, and 20%, respectively, of patients. Conclusions: Our data confirm that evaluation of drug allergy for suspected POH can be performed before 6 weeks after the event, and there is no maximal upper time limit disclosing ex vivo and in vitro testing.

Published
2022

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