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2. Evolutionary trade-off between heat shock resistance, growth at high temperature, and virulence expression in Salmonella Typhimurium

Author

Berdejo, Daniel, primary, Mortier, Julien, additional, Cambré, Alexander, additional, Sobota, Malgorzata, additional, Van Eyken, Ronald, additional, Kim, Tom Dongmin, additional, Vanoirbeek, Kristof, additional, García Gonzalo, Diego, additional, Pagán, Rafael, additional, Diard, Médéric, additional, and Aertsen, Abram, additional

Published
2024
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3. Erratum for Mortier and Gayán et al., “Gene Erosion Can Lead to Gain-of-Function Alleles That Contribute to Bacterial Fitness”

Author

Mortier, Julien, primary, Gayán, Elisa, additional, Van Eyken, Ronald, additional, Torres Montaguth, Oscar Enrique, additional, Khodaparast, Ladan, additional, Khodaparast, Laleh, additional, Houben, Bert, additional, Carpentier, Sebastien, additional, Rousseau, Frederic, additional, Schymkowitz, Joost, additional, and Aertsen, Abram, additional

Published
2021
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4. Gene Erosion Can Lead to Gain-of-Function Alleles That Contribute to Bacterial Fitness

Author

Mortier, Julien, Gayán, Elisa, Van Eyken, Ronald, Torres Montaguth, Oscar Enrique, Khodaparast, Ladan, Khodaparast, Laleh, Houben, Bert, Carpentier, Sebastien, Rousseau, Frederic, Schymkowitz, Joost, and Aertsen, Abram

Subjects
Genetics, 0303 health sciences, 030306 microbiology, heat resistance, Robustness (evolution), Biology, Protein aggregation, medicine.disease_cause, Directed evolution, protein aggregates, Microbiology, QR1-502, 03 medical and health sciences, Protein structure, Virology, Heat shock protein, evolution, medicine, genetics, Allele, Gene, Escherichia coli, 030304 developmental biology, Research Article
Abstract

Despite our extensive knowledge of the genetic regulation of heat shock proteins (HSPs), the evolutionary routes that allow bacteria to adaptively tune their HSP levels and corresponding proteostatic robustness have been explored less. In this report, directed evolution experiments using the Escherichia coli model system unexpectedly revealed that seemingly random single mutations in its tnaA gene can confer significant heat resistance. Closer examination, however, indicated that these mutations create folding-deficient and aggregation-prone TnaA variants that in turn can endogenously and preemptively trigger HSP expression to cause heat resistance. These findings, importantly, demonstrate that even erosive mutations with disruptive effects on protein structure and functionality can still yield true gain-of-function alleles with a selective advantage in adaptive evolution. ispartof: MBIO vol:12 issue:4 ispartof: location:United States status: accepted

Published
2021

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