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1. Western blot seroindeterminate individuals for human T-lymphotropic virus I/II (HTLV-I/II) in Fortaleza (Brazil): a serological and molecular diagnostic and epidemiological approach

Author

UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique, UCL - (SLuc) Service de microbiologie, Santos, Terezinha de Jesus Teixeira, Costa, Carlos Maurício de Castro, Goubau, Patrick, Vandamme, Anne-Mieke, Desmyter, Jan, Van Doren, Sonia, Mota, Rosa M. S., de Castro Costa, Francine Bovy, Oliveira, Ana C. S., Barreto, Vania, Gomes, A. F., Carneiro-Proietti, Anna B., de Bruin, Veralice Meireles Sales, de Sousa, Francisca C. F., Oriá, Reinaldo Barreto, UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique, UCL - (SLuc) Service de microbiologie, Santos, Terezinha de Jesus Teixeira, Costa, Carlos Maurício de Castro, Goubau, Patrick, Vandamme, Anne-Mieke, Desmyter, Jan, Van Doren, Sonia, Mota, Rosa M. S., de Castro Costa, Francine Bovy, Oliveira, Ana C. S., Barreto, Vania, Gomes, A. F., Carneiro-Proietti, Anna B., de Bruin, Veralice Meireles Sales, de Sousa, Francisca C. F., and Oriá, Reinaldo Barreto

Abstract

How to handle Western blot (WB) seroindeterminate individuals for Human T-lymphotropic Virus 1/2 (HTLV-1/2) constitutes a challenge for blood banks and families. We made a cross-sectional study of 191 enzyme linked immunoassay (EIA) reactive individuals from the hematological center (HEMOCE) of Fortaleza (Brazil), examining their serological (WB) and molecular (PCR) diagnosis, and demographic profiles, as well as a possible association of their condition with other infectious pathologies and risk factors. Ethical institutional approval and personal consent were obtained. Out of 191 EIA reactive individuals, 118 were WB seroindeterminate and 73 were seropositive for HTLV-1/2. In the PCR analysis of 41 WB seroindeterminate individuals, 9 (22%) were positive and 32 (78%) were negative for HTLV-1/2. The demographic analysis indicated a trend towards a predominance of males among the seroindeterminate individuals and females in the seropositive ones. The seroindeterminate individuals were younger than the seropositive ones. We did not find any association of these conditions with syphilis, Chagas disease or HIV or hepatitis, and with risk factors such as breast-feeding, blood transfusion, STD (syphilis) and IDU.

Published
2003

2. Western blot seroindeterminate individuals for human T-lymphotropic virus I/II (HTLV-I/II) in Fortaleza (Brazil): a serological and molecular diagnostic and epidemiological approach.

Author

Santos Tde J, Costa CM, Goubau P, Vandamme AM, Desmyter J, Van Doren S, Mota RM, de Castro Costa FB, Oliveira AC, Barreto V, Gomes AF, Carneiro-Proietti AB, de Bruin VM, de Sousa FC, and Oriá RB

Subjects
Blotting, Western, Brazil epidemiology, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay, Female, HTLV-I Infections epidemiology, HTLV-II Infections epidemiology, Humans, Male, Polymerase Chain Reaction, Risk Factors, DNA Primers genetics, HTLV-I Infections diagnosis, HTLV-II Infections diagnosis, Human T-lymphotropic virus 1 genetics, Human T-lymphotropic virus 2 genetics
Abstract

How to handle Western blot (WB) seroindeterminate individuals for Human T-lymphotropic Virus 1/2 (HTLV-1/2) constitutes a challenge for blood banks and families. We made a cross-sectional study of 191 enzyme linked immunoassay (EIA) reactive individuals from the hematological center (HEMOCE) of Fortaleza (Brazil), examining their serological (WB) and molecular (PCR) diagnosis, and demographic profiles, as well as a possible association of their condition with other infectious pathologies and risk factors. Ethical institutional approval and personal consent were obtained. Out of 191 EIA reactive individuals, 118 were WB seroindeterminate and 73 were seropositive for HTLV-1/2. In the PCR analysis of 41 WB seroindeterminate individuals, 9 (22%) were positive and 32 (78%) were negative for HTLV-1/2. The demographic analysis indicated a trend towards a predominance of males among the seroindeterminate individuals and females in the seropositive ones. The seroindeterminate individuals were younger than the seropositive ones. We did not find any association of these conditions with syphilis, Chagas disease or HIV or hepatitis, and with risk factors such as breast-feeding, blood transfusion, STD (syphilis) and IDU.

Published
2003
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