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Your search keyword '"Van Der Sand, L C"' showing total 5 results
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5 results on '"Van Der Sand, L C"'

4. ESR1polymorphisms and statin therapy: a sex-specific approach

Author

Smiderle, L, Fiegenbaum, M, Hutz, M H, Van Der Sand, C R, Van Der Sand, L C, Ferreira, M E W, Pires, R C, and Almeida, S

Abstract

Lipid-lowering therapy has shown a high degree of variability in clinical response and there is evidence that the variability in drug response between individuals is due to genetic factors. Thirteen single nucleotide polymorphisms (SNPs) within the ESR1gene were evaluated with basal lipid and lipoprotein levels, as well as response to lipid-lowering therapy, in 495 hypercholesterolemic individuals of European descent receiving simvastatin or atorvastatin. Significant associations were detected between rs4870061 (P=0.040, corrected P-value (PC)=0.440), rs1801132 (P=0.002, PC=0.022) and the SNP rs3020314 (P=0.013, PC=0.143) with triglyceride (TG) baseline levels. The rs4870061 was also associated with high-density lipoprotein cholesterol (HDL-C) baseline levels (P=0.045, PC=0.495). Regarding statin efficacy, rs2234693 C/C was associated with greater HDL-C increase (P=0.037; PC=0.407) and rs3798577 T allele was associated with greater total cholesterol (TC) reduction (P=0.019; PC=0.209) and greater TG reduction (P=0.026; PC=0.286). These associations suggest that ESR1polymorphisms are in part responsible for the TC, HDL-C and TG variation levels and this effect may be sex-specific.

Published
2016
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5. [Surgical myocardial revascularization in young patients].

Author

Gustavo Thomé L, Vitola D, Van der Sand LC, Ricardo Sant'Anna J, Kalil RA, Prates P, Lucchese FA, Nesralla IA, Pereira E, and Rodrigues R

Subjects
Adult, Evaluation Studies as Topic, Follow-Up Studies, Humans, Retrospective Studies, Risk Factors, Myocardial Ischemia surgery, Myocardial Revascularization mortality
Abstract

Purpose: To determine early and late results of surgical myocardial revascularization (SMR) in young patients., Methods: We studied retrospectively 73 patients aging less than 40 years and submitted to SMR between 1975 and 1989. The method used was patient card review and thelephone contact with the patient or his physician., Results: Follow-up was obtained in all cases in a period of 2 to 185 (59.9 +/- 41.0) months. Of the coronary risk factors smoking was the most frequent. One vessel coronary artery disease was observed in 16 (21.9%) patients, 2 and 3 vessel coronary artery disease in 26 (35.6%) and 32 (43.8%) patients respectively. SMR was considered complete in 68 (93.2%) patients. An associated procedure was performed on 10 cases: Left ventricular aneurysm repair in 9 (12.3%) and mitral valve replacement in one (1.4%). Perioperative myocardial infarction occurred in 7 (9.5%) patients and one of them died (operative mortality: 1.4%). During follow-up, 6 (8.3%) patients died with an actuarial survival rate of 89.1% at 15 years. An event free survival rate of 68.3% was observed at 10 years. From 66 survivors, 53 (80.3%) were asymptomatic at late follow-up and 48 (72.7%) patients returned to work., Conclusion: Surgical myocardial revascularization in young patients associated with medical treatment, has good early and late results with a high percentage of patients asymptomatic and reemployed at a late follow-up.

Published
1996

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