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Your search keyword '"Van Der Kraak, Lauren"' showing total 21 results
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21 results on '"Van Der Kraak, Lauren"'

1. The gut protist Tritrichomonas arnold restrains virus-mediated loss of oral tolerance by modulating dietary antigen-presenting dendritic cells

Author

Medina Sanchez, Luzmariel, Siller, Magdalena, Zeng, Yanlin, Brigleb, Pamela H., Sangani, Kishan A., Soto, Ariadna S., Engl, Clarisse, Laughlin, Colin R., Rana, Mohit, Van Der Kraak, Lauren, Pandey, Surya P., Bender, Mackenzie J., Fitzgerald, Britney, Hedden, Lee, Fiske, Kay, Taylor, Gwen M., Wright, Austin P., Mehta, Isha D., Rahman, Syed A., Galipeau, Heather J., Mullett, Steven J., Gelhaus, Stacy L., Watkins, Simon C., Bercik, Premysl, Nice, Timothy J., Jabri, Bana, Meisel, Marlies, Das, Jishnu, Dermody, Terence S., Verdú, Elena F., and Hinterleitner, Reinhard

Published
2023
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4. A gut commensal protist protects against virus-mediated loss of oral tolerance

Author

Siller, Magdalena, primary, Zeng, Yanlin, additional, Sanchez, Luzmariel Medina, additional, Brigleb, Pamela H., additional, Sangani, Kishan A., additional, Rana, Mohit, additional, Van Der Kraak, Lauren, additional, Pandey, Surya P., additional, Bender, Mackenzie J., additional, Fitzgerald, Britney, additional, Hedden, Lee, additional, Fiske, Kay, additional, Taylor, Gwen M., additional, Rahman, Syed A, additional, Galipeau, Heather J., additional, Mullet, Steven J., additional, Wendell, Stacy G., additional, Watkins, Simon C., additional, Bercik, Premysl, additional, Das, Jishnu, additional, Meisel, Marlies, additional, Jabri, Bana, additional, Dermody, Terence S., additional, Verdú, Elena F., additional, and Hinterleitner, Reinhard, additional

Published
2022
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15. 5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers

Author

Van Der Kraak, Lauren, primary, Goel, Gaurav, additional, Ramanan, Krishnaveni, additional, Kaltenmeier, Christof, additional, Zhang, Lin, additional, Normolle, Daniel P., additional, Freeman, Gordon J., additional, Tang, Daolin, additional, Nason, Katie S., additional, Davison, Jon M., additional, Luketich, James D., additional, Dhupar, Rajeev, additional, and Lotze, Michael T., additional

Published
2016
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18. Positional Mapping and Candidate Gene Analysis of the Mouse Ccs3 Locus That Regulates Differential Susceptibility to Carcinogen-Induced Colorectal Cancer

Author

Meunier, Charles, primary, Van Der Kraak, Lauren, additional, Turbide, Claire, additional, Groulx, Normand, additional, Labouba, Ingrid, additional, Cingolani, Pablo, additional, Blanchette, Mathieu, additional, Yeretssian, Garabet, additional, Mes-Masson, Anne-Marie, additional, Saleh, Maya, additional, Beauchemin, Nicole, additional, and Gros, Philippe, additional

Published
2013
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19. Mutation analysis in Bardet–Biedl syndrome by DNA pooling and massively parallel resequencing in 105 individuals

Author

Janssen, Sabine, primary, Ramaswami, Gokul, additional, Davis, Erica E., additional, Hurd, Toby, additional, Airik, Rannar, additional, Kasanuki, Jennifer M., additional, Van Der Kraak, Lauren, additional, Allen, Susan J., additional, Beales, Philip L., additional, Katsanis, Nicholas, additional, Otto, Edgar A., additional, and Hildebrandt, Friedhelm, additional

Published
2010
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21. Positional Mapping and Candidate Gene Analysis of the Mouse Ccs3 Locus That Regulates Differential Susceptibility to Carcinogen-Induced Colorectal Cancer.

Author

Meunier, Charles, Van Der Kraak, Lauren, Turbide, Claire, Groulx, Normand, Labouba, Ingrid, Cingolani, Pablo, Blanchette, Mathieu, Yeretssian, Garabet, Mes-Masson, Anne-Marie, Saleh, Maya, Beauchemin, Nicole, and Gros, Philippe

Subjects
*GENE mapping, *LOCUS (Genetics), *DISEASE susceptibility, *CARCINOGENESIS, *COLON cancer, *DRUG side effects, *CHROMOSOMES, *LABORATORY mice
Abstract

The Ccs3 locus on mouse chromosome 3 regulates differential susceptibility of A/J (A, susceptible) and C57BL/6J (B6, resistant) mouse strains to chemically-induced colorectal cancer (CRC). Here, we report the high-resolution positional mapping of the gene underlying the Ccs3 effect. Using phenotype/genotype correlation in a series of 33 AcB/BcA recombinant congenic mouse strains, as well as in groups of backcross populations bearing unique recombinant chromosomes for the interval, and in subcongenic strains, we have delineated the maximum size of the Ccs3 physical interval to a ∼2.15 Mb segment. This interval contains 12 annotated transcripts. Sequencing of positional candidates in A and B6 identified many either low-priority coding changes or non-protein coding variants. We found a unique copy number variant (CNV) in intron 15 of the Nfkb1 gene. The CNV consists of two copies of a 54 bp sequence immediately adjacent to the exon 15 splice site, while only one copy is found in CRC-susceptible A. The Nfkb1 protein (p105/p50) expression is much reduced in A tumors compared to normal A colonic epithelium as analyzed by immunohistochemistry. Studies in primary macrophages from A and B6 mice demonstrate a marked differential activation of the NfκB pathway by lipopolysaccharide (kinetics of stimulation and maximum levels of phosphorylated IκBα), with a more robust activation being associated with resistance to CRC. NfκB has been previously implicated in regulating homeostasis and inflammatory response in the intestinal mucosa. The interval contains another positional candidate Slc39a8 that is differentially expressed in A vs B6 colons, and that has recently been associated in CRC tumor aggressiveness in humans. [ABSTRACT FROM AUTHOR]

Published
2013
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